March 2019 Supplement Research Papers

• March 4

  • Probiotic characterization of Lactobacillus brevis KU15153 showing antimicrobial and antioxidant effect isolated from kimchi

    • 2019-03-04
    • Food Science and Biotechnology 28(5)
    • • H. Jang
      • N. Lee
      • H. Paik

    • PubMed: 31695951
    • DOI: 10.1007/S10068-019-00576-X

    7 Insights on

    • Increased Antioxidant Activity
    • Enhanced Antimicrobial Resistance
    • Increased Cell Adhesion
    • Increased Antibiotic Susceptibility
    • Reduced Production of Carcinogenic Enzymes
    • Improved Gastric Survival
    • Increased Intestinal Cell Adherence

    • Low evidence

  • Saccharomyces boulardii CNCM I-745 Modulates the Fecal Bile Acids Metabolism During Antimicrobial Therapy in Healthy Volunteers

    • 2019-03-04
    • RCT
    • Frontiers in Microbiology 10
    • • C. Kelly
      • Caroline Chong Nguyen
      • L. Palmieri
      • K. Pallav
      • S. Dowd
      • L. Humbert
      • P. Seksik
      • A. Bado
      • B. Coffin
      • D. Rainteau
      • T. Kabbani
      • H. Duboc

    • PubMed: 30881353
    • DOI: 10.3389/fmicb.2019.00336

    3 Insights on

    • Reduced Clostridium difficile Infection
    • Stabilized Fecal Secondary Bile Acids
    • Reduced Fecal Cholic Acid Increase

    • High evidence
• March 5

  • Bacillus amyloliquefaciens BLCC1-0238 Can Effectively Improve Laying Performance and Egg Quality Via Enhancing Immunity and Regulating Reproductive Hormones of Laying Hens

    • 2019-03-05
    • RCT · n = 240
    • Probiotics and Antimicrobial Proteins 12(1)
    • • Yufa Zhou
      • Song Li
      • Quanhai Pang
      • Z. Miao

    • PubMed: 30834486
    • DOI: 10.1007/s12602-019-9524-1

    3 Insights on

    • Enhanced Antioxidant Enzyme Activity
    • Enhanced Immunity
    • Reduced Stress Response

    • Low evidence
    • Animal Study
• March 8

  • Safety Assessment of Potential Probiotic Lactobacillus fermentum MTCC-5898 in Murine Model after Repetitive Dose for 28 Days (Sub-Acute Exposure)

    • 2019-03-08
    • Clinical Trial
    • Probiotics and Antimicrobial Proteins 12(1)
    • • M. Samtiya
      • M. I. Bhat
      • Taruna Gupta
      • S. Kapila
      • R. Kapila

    • PubMed: 30847835
    • DOI: 10.1007/s12602-019-09529-6

    3 Insights on

    • No Adverse Health Effects
    • Improved Immune Homeostasis
    • Maintained Gut Permeability

    • Low evidence
    • Animal Study
• March 10

  • Effect of oral supplementation of probiotic strains of Lactobacillus rhamnosus and Enterococcus faecium on the composition of the faecal microbiota of foals.

    • 2019-03-10
    • RCT · n = 34
    • Journal of Animal Physiology and Animal Nutrition 103(3)
    • • V. Urubschurov
      • Christina Stroebel
      • Elena Günther
      • K. Romanowski
      • K. Büsing
      • A. Zeyner

    • PubMed: 30854744
    • DOI: 10.1111/jpn.13079

    1 Insight on

    • Maintained Bacterial Diversity

    • Low evidence
    • Animal Study
• March 13

  • Effects of long-term administration of Lactobacillus reuteri DSM-17938 on circulating levels of 5-HT and BDNF in adults with functional constipation.

    • 2019-03-13
    • RCT · n = 56
    • Beneficial Microbes 10(2)
    • • G. Riezzo
      • G. Chimienti
      • A. Orlando
      • B. D’Attoma
      • C. Clemente
      • F. Russo

    • PubMed: 30574801
    • DOI: 10.3920/BM2018.0050

    3 Insights on

    • Reduced Serum Serotonin Levels
    • Reduced Serum BDNF Levels
    • Improved Functional Constipation

    • High evidence

  • Bacillus clausii UBBC-07 reduces severity of diarrhoea in children under 5 years of age: a double blind placebo controlled study.

    • 2019-03-13
    • RCT
    • Beneficial Microbes 10(2)
    • • M. Sudha
      • N. Jayanthi
      • D. Pandey
      • A. Verma

    • PubMed: 30638396
    • DOI: 10.3920/BM2018.0094

    4 Insights on

    • Improved Stool Consistency
    • Reduced Duration of Diarrhea
    • Reduced Stool Frequency
    • Reduced Diarrhea Frequency

    • High evidence

  • Bifidobacterium infantis M-63 improves mental health in victims with irritable bowel syndrome developed after a major flood disaster.

    • 2019-03-13
    • RCT · n = 53
    • Beneficial Microbes 10(2)
    • • Z. F. Ma
      • N. Yusof
      • N. Hamid
      • R. M. Lawenko
      • W. M. Z. W. Mohammad
      • M. Liong
      • H. Sugahara
      • T. Odamaki
      • J. Xiao
      • Y. Y. Lee

    • PubMed: 30525951
    • DOI: 10.3920/BM2018.0008

    5 Insights on

    • Reduced Anxiety Levels
    • Improved Gut Microbiota Balance
    • Reduced Anxiety
    • Improved Perceived Mental Well-being
    • Reduced Bodily Pain

    • High evidence
• March 16

  • Therapeutic Prospective of a Spore-Forming Probiotic—Bacillus clausii UBBC07 Against Acetaminophen-Induced Uremia in Rats

    • 2019-03-16
    • RCT · n = 18
    • Probiotics and Antimicrobial Proteins 12(1)
    • • C. Patel
      • Priyanshi Patel
      • S. Acharya

    • PubMed: 30879230
    • DOI: 10.1007/s12602-019-09540-x

    4 Insights on

    • Reduced Hepatic Oxidative Stress
    • Improved Antioxidant Activity
    • Reduced Uremia Indicators
    • Reduced Uremia Levels

    • Low evidence
    • Animal Study
• March 18

  • Prevention of respiratory syncytial virus infection with probiotic lactic acid bacterium Lactobacillus gasseri SBT2055

    • 2019-03-18
    • Clinical Trial
    • Scientific Reports 9(1)
    • • K. Eguchi
      • N. Fujitani
      • H. Nakagawa
      • T. Miyazaki

    • PubMed: 30886158
    • DOI: 10.1038/s41598-019-39602-7

    9 Insights on

    • Reduced Pro-Inflammatory Cytokines
    • Reduced RSV Titre in Lung
    • Maintained Body Weight Post-Virus Infection
    • Reduced Expression of Pro-Inflammatory Cytokines in Lung
    • Reduced RSV Replication
    • Maintained Body Weight
    • Stable Body Weight Post-RSV Infection
    • Reduced RSV Viral Load in Lungs
    • Inhibition of RSV Replication

    • Low evidence
    • Highly Cited
    • Rigorous Journal
    • Animal Study

  • Effects of Bacillus subtilis DSM32315 supplementation and dietary crude protein level on performance, gut barrier function and microbiota profile in weaned piglets1.

    • 2019-03-18
    • RCT
    • Journal of Animal Science 97(5)
    • • Wenjie Tang
      • Ye Qian
      • B. Yu
      • Zhang Tao
      • Jun Gao
      • Jun He
      • Zhiqing Huang
      • P. Zheng
      • X. Mao
      • Junqiu Luo
      • Jie Yu
      • Daiwen Chen

    • PubMed: 30883644
    • DOI: 10.1093/jas/skz090

    5 Insights on

    • Improved Gut Microbiota
    • Improved Intestinal Barrier Function
    • Increased Short-Chain Fatty Acid Levels
    • Improved Intestinal Morphology
    • Improved Growth Performance

    • High evidence
    • Rigorous Journal

  • Probiotic Lactobacillus rhamnosus GR-1 is a unique prophylactic agent that suppresses infection-induced myometrial cell responses.

    • 2019-03-18
    • Scientific reports 9(1)
    • • Bona Kim
      • Oksana Shynlova
      • Stephen Lye

    • PubMed: 30886179
    • DOI: 10.1038/s41598-019-41133-0

    2 Insights on

    • Reduced Preterm Births
    • Reduced Inflammation

    • Low evidence
    • Rigorous Journal
• March 19

  • Enhancement of bile resistance by maltodextrin supplementation in Lactobacillus plantarum Lp-115.

    • 2019-03-19
    • Journal of applied microbiology 126(5)
    • • Y Zhou
      • J-Q Wang
      • C-H Hu
      • L-Q Ren
      • D-C Wang
      • B-C Ye

    • PubMed: 30790408
    • DOI: 10.1111/jam.14229

    2 Insights on

    • Improved Tolerance to Bile Salts
    • Increased Cell Hydrophobicity

    • Low evidence
• March 20

  • Protective effects of enhanced minor ginsenosides in Lactobacillus fermentum KP-3-fermented ginseng in mice fed a high fat diet.

    • 2019-03-20
    • Clinical Trial
    • Food & Function 9(11)
    • • Bo Nan
      • Yanlong Liu
      • Ying You
      • Wancong Li
      • Jing-jing Fan
      • Yushan Wang
      • Chunhong Piao
      • D. Hu
      • Guilin Lu
      • Yuhua Wang

    • PubMed: 30397690
    • DOI: 10.1039/c8fo01056k

    6 Insights on

    • Reduced Aminotransferase Levels
    • Reduced Liver Damage
    • Reduced Liver Lipid Accumulation
    • Reduced Serum Total Cholesterol Levels
    • Reduced AST Levels
    • Reduced Serum LDL Levels

    • Low evidence
    • Animal Study
• March 25

  • Bacillus coagulans Unique IS2 in Constipation: A Double-Blind, Placebo-Controlled Study

    • 2019-03-25
    • RCT · n = 100
    • Probiotics and Antimicrobial Proteins 12(2)
    • • R. Madempudi
      • J. Neelamraju
      • J. Ahire
      • S. Gupta
      • V. Shukla

    • PubMed: 30911991
    • DOI: 10.1007/s12602-019-09542-9

    5 Insights on

    • Increased Bowel Movement Frequency
    • Reduced Abdominal Pain Severity
    • Normalized Stool Consistency
    • Reduced Painful Defecation
    • Relief from Incomplete Evacuation

    • High evidence
• March 26

  • Mechanistic Insights Into Probiotic Properties of Lactic Acid Bacteria Associated With Ethnic Fermented Dairy Products.

    • 2019-03-26
    • Review
    • Frontiers in microbiology 10
    • • Tamoghna Ghosh
      • Arun Beniwal
      • Anupama Semwal
      • Naveen Kumar Navani

    • PubMed: 30972037
    • DOI: 10.3389/fmicb.2019.00502

    1 Insight on

    • Improved Probiotic Potential

    • Low evidence
• March 29

  • Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial

    • 2019-03-29
    • RCT · n = 79
    • BMC Complementary and Alternative Medicine 19(1)
    • • Su-Jin Jung
      • Eun-Soo Jung
      • Eun‐Kyung Choi
      • H. Sin
      • Ki-Chan Ha
      • S. Chae

    • PubMed: 30925876
    • DOI: 10.1186/s12906-019-2483-y

    4 Insights on

    • Improved Immune Function
    • Improved Natural Killer Cell Activity
    • Enhanced Natural Killer Cell Activity
    • Enhanced Cell-Mediated Immunity

    • High evidence
    • Rigorous Journal
• Undated – 6 supplement studies

  • Thirty Years of Lactobacillus rhamnosus GG: A Review.

    • 2019-03
    • Systematic Review
    • Journal of Clinical Gastroenterology 53(Supplement 1)
    • • L. Capurso

    • PubMed: 30741841
    • DOI: 10.1097/MCG.0000000000001170

    42 Insights on

    • Improved Intestinal Barrier Function
    • Improved Gastrointestinal Health
    • Improved Immune Response
    • Reduced Incidence of Colon Cancer
    • Reduced Pathogen Growth
    • Improved Gut Health
    • Reduced Pathogen Infection
    • Reduced Allergic Symptoms
    • Reduced Pathogenic Load
    • Reduced Respiratory Tract Infections
    • Improved Irritable Bowel Syndrome Symptoms
    • Reduced Liver Disease Symptoms
    • Improved Symptoms of Chronic Condition
    • Reduced Pathogen Activity
    • Enhanced Intestinal Mucosal Cell Protection
    • Reduced Diarrhea
    • Improved Intestinal Crypt Survival
    • Reduced Intestinal Epithelial Apoptosis
    • Maintained Cytoskeletal Integrity
    • Enhanced Type 1 Immune Response
    • Reduced Pathogen Incidence
    • Enhanced Mucosal Protection
    • Inhibition of Salmonella Infection
    • Increased Adhesion to Enterocytes
    • Improved Cardiovascular Health
    • Reduced Pathogen Colonization
    • Increased Intestinal Crypt Survival
    • Reduced Pathogen Inhibition (e.g. Salmonella Species)
    • Prevention of Nonalcoholic Fatty Liver Disease
    • Improved Adherence to Enterocytes
    • Improved Effectiveness in Inflammatory Bowel Disease
    • Improved Allergy Effectiveness
    • Improved Cardiovascular Disease Outcomes
    • Improved Effectiveness in Nonalcoholic Steatohepatitis
    • Improved Effectiveness in Cystic Fibrosis Treatment
    • Improved Effectiveness in Cancer Treatment
    • Improved Health in Elderly Populations
    • Improved Sports Performance
    • Improved Respiratory Tract Health
    • Improved Liver Health
    • Managed Cystic Fibrosis
    • Enhanced Sport Performance

    • High evidence
    • Highly Cited

  • Lactobacillus johnsonii L531 reduces pathogen load and helps maintain short-chain fatty acid levels in the intestines of pigs challenged with Salmonella enterica Infantis.

    • 2019-03
    • Clinical Trial
    • Veterinary Microbiology 230
    • • Ting He
      • Yaohong Zhu
      • Jiao Yu
      • B. Xia
      • Xiao Liu
      • Gui-Yan Yang
      • Jinhui Su
      • Liang Guo
      • Mengling Wang
      • Jiufeng Wang

    • PubMed: 30827387
    • DOI: 10.1016/j.vetmic.2019.02.003

    7 Insights on

    • Increased Body Weight
    • Maintained Short-Chain Fatty Acid Levels During Antibiotic Treatment
    • Reduced Pathogenic Load
    • Reduced Salmonella Colonization
    • Improved Salmonella Clearance
    • Reduced Salmonella Translocation
    • Improved Short-Chain Fatty Acids Levels

    • Low evidence
    • Animal Study

  • Probiotics improve glucose and lipid metabolism in pregnant women: a meta-analysis.

    • 2019-03
    • Meta-Analysis · n = 139
    • Annals of translational medicine 7(5)
    • • Man-Man Han
      • Jin-Fang Sun
      • Xiang-Hui Su
      • You-Fan Peng
      • Hemant Goyal
      • Chun-Hua Wu
      • Xiang-Yun Zhu
      • Ling Li

    • PubMed: 31019949
    • DOI: 10.21037/atm.2019.01.61

    4 Insights on

    • Improved Insulin Sensitivity
    • Improved Lipid Metabolism
    • Improved Glucose Metabolism
    • Reduced Prevalence of Gestational Diabetes Mellitus

    • High evidence

  • Effects of Lactococcus lactis subsp. lactis JCM5805 on colonization dynamics of gut microbiota and regulation of immunity in early ontogenetic stages of tilapia

    • 2019-03
    • RCT
    • Fish & Shellfish Immunology 86
    • • Y. Xia
      • Jianmeng Cao
      • Miao Wang
      • Mai-xin Lu
      • Gang Chen
      • F. Gao
      • Zhigang Liu
      • Defeng Zhang
      • X. Ke
      • Mengmeng Yi

    • PubMed: 30428393
    • DOI: 10.1016/j.fsi.2018.11.022

    1 Insight on

    • Enhanced Disease Resistance

    • High evidence

  • Bacillus amyloliquefaciens spray improves the growth performance, immune status, and respiratory mucosal barrier in broiler chickens

    • 2019-03
    • RCT · n = 320
    • Poultry Science 98(3)
    • • S. Luan
      • Y. Sun
      • Y. Wang
      • R N Sa
      • H F Zhang

    • PubMed: 30285152
    • DOI: 10.3382/ps/pey478

    3 Insights on

    • Improved Growth Performance
    • Enhanced Immune Status
    • Improved Respiratory Mucosal Barrier Function

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • The impact of Bacillus subtilis 18 isolated from Tibetan yaks on growth performance and gut microbial community in mice.

    • 2019-03
    • RCT · n = 20
    • Microbial Pathogenesis 128
    • • Aoyun Li
      • Xiong Jiang
      • Yaping Wang
      • Li-hong Zhang
      • Hui Zhang
      • K. Mehmood
      • Zhixing Li
      • M. Waqas
      • Jia-kui Li

    • PubMed: 30583023
    • DOI: 10.1016/j.micpath.2018.12.031

    4 Insights on

    • Improved Average Daily Gain
    • Improved Gut Mucosal Histology
    • Increased Abundance of Lactobacillus
    • Improved Immune System Activity

    • Low evidence
    • Animal Study