April 2019 Supplement Research Papers

• April 1

  • Probiotic administration of lactobacillus rhamnosus GR-1 attenuates atherosclerotic plaque formation in ApoE-/- mice fed with a high-fat diet.

    • 2019-04-01
    • European review for medical and pharmacological sciences 23(8)
    • • Y Fang
      • H-Q Chen
      • X Zhang
      • H Zhang
      • J Xia
      • K Ding
      • Z-Y Fang

    • PubMed: 31081110
    • DOI: 10.26355/eurrev_201904_17722

    3 Insights on

    • Reduced Inflammation
    • Reduced Oxidative Stress
    • Reduced Atherosclerotic Plaque Formation

    • Low evidence
• April 3

  • Lactobacillus fermentum species ameliorate dextran sulfate sodium-induced colitis by regulating the immune response and altering gut microbiota

    • 2019-04-03
    • Clinical Trial
    • Gut Microbes 10(6)
    • • You-jin Jang
      • Woon-Ki Kim
      • D. Han
      • Kiuk Lee
      • Gwangpyo Ko

    • PubMed: 30939976
    • DOI: 10.1080/19490976.2019.1589281

    6 Insights on

    • Improved Gut Microbiota Diversity
    • Improved Intestinal Barrier Function
    • Reduced Colitis Symptoms
    • Increased Regulatory T Cell Populations
    • Reduced Pro-inflammatory Cytokine Levels
    • Increased Abundance of Beneficial Microorganisms

    • Low evidence
    • Highly Cited
    • Animal Study

  • Lactobacillus helveticus KLDS1.8701 alleviates d-galactose-induced aging by regulating Nrf-2 and gut microbiota in mice.

    • 2019-04-03
    • Clinical Trial
    • Food & Function 9(12)
    • • Bailiang Li
      • S. Evivie
      • Jingjing Lu
      • Y. Jiao
      • Chengfeng Wang
      • Ziye Li
      • Fei Liu
      • G. Huo

    • PubMed: 30488048
    • DOI: 10.1039/c8fo01768a

    5 Insights on

    • Reduced Hepatic Oxidative Stress
    • Improved Aging-Related Changes
    • Improved Gut Microbiome Composition
    • Improved Free Radical Scavenging Activity
    • Reduced Aging-related Changes

    • Low evidence
    • Animal Study
• April 4

  • Exopolysaccharide-Producing Bifidobacterium adolescentis Strains with Similar Adhesion Property Induce Differential Regulation of Inflammatory Immune Response in Treg/Th17 Axis of DSS-Colitis Mice

    • 2019-04-04
    • Clinical Trial
    • Nutrients 11(4)
    • • Rui Yu
      • F. Zuo
      • Huiqin Ma
      • Shangwu Chen

    • PubMed: 30987344
    • DOI: 10.3390/nu11040782

    2 Insights on

    • Reduced Colitis Symptoms
    • Modulated Immune Response

    • Low evidence
    • Animal Study
• April 5

  • Probiotics in Extraintestinal Diseases: Current Trends and New Directions.

    • 2019-04-05
    • Review
    • Nutrients 11(4)
    • • Despoina E Kiousi
      • Athanasios Karapetsas
      • Kyriaki Karolidou
      • Mihalis I Panayiotidis
      • Aglaia Pappa
      • Alex Galanis

    • PubMed: 30959761
    • DOI: 10.3390/nu11040788

    2 Insights on

    • Improved Skin Hydration
    • Improved Skin Health

    • Moderate evidence
    • Rigorous Journal
• April 10

  • Enterococcus faecium secreted antigen A generates muropeptides to enhance host immunity and limit bacterial pathogenesis

    • 2019-04-10
    • eLife 8
    • • Byungchul Kim
      • Yen-Chih Wang
      • C. Hespen
      • Juliel Espinosa
      • J. Salje
      • Kavita J. Rangan
      • D. Oren
      • J. Kang
      • Virginia A. Pedicord
      • H. Hang

    • PubMed: 30969170
    • DOI: 10.7554/eLife.45343

    2 Insights on

    • Improved Intestinal Barrier Function
    • Improved Pathogen Tolerance

    • Low evidence
    • Rigorous Journal

  • Rectal and Vaginal Eradication of Streptococcus agalactiae (GBS) in Pregnant Women by Using Lactobacillus salivarius CECT 9145, A Target-specific Probiotic Strain

    • 2019-04-10
    • Clinical Trial · n = 136
    • Nutrients 11(4)
    • • V. Martín
      • Nívia Cárdenas
      • S. Ocaña
      • M. Marín
      • Rebeca Arroyo
      • David Beltrán
      • C. Badiola
      • L. Fernández
      • J. M. Rodríguez

    • PubMed: 30974819
    • DOI: 10.3390/nu11040810

    1 Insight on

    • Reduced GBS Colonization

    • High evidence
• April 11

  • Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial

    • 2019-04-11
    • RCT
    • Nutrients 11(4)
    • • Yen-Wenn Liu
      • M. Liong
      • Y. Chung
      • Hui-Yi Huang
      • W. Peng
      • Yun-Fang Cheng
      • Yu-Siou Lin
      • Yu-Yu Wu
      • Y. Tsai

    • PubMed: 30979038
    • DOI: 10.3390/nu11040820

    18 Insights on

    • Improved Opposition and Defiance Behaviors
    • Improved SNAP-IV Score for Younger Children
    • Improved SNAP-IV Scores
    • Improved Specific Elements of ASD Behaviors
    • Improved Behavioral Health
    • Improved Behavioral Symptoms in Younger Children
    • Improved ASD Symptoms
    • Improved Specific Elements Within Assessed Measures
    • Improved Behavioral Elements
    • Improved SNAP-IV Total Score
    • Reduced Oppositional/Defiant Behaviors
    • Improved Various Elements
    • Notable Improvement in Multiple Health Metrics
    • Improved SNAP-IV Total Score for Children Aged 7-12
    • Notable Overall Improvement
    • Improved General Behavioral Scores
    • Improved Secondary Symptoms
    • Improved Autism Behavioral Scores

    • High evidence
    • Highly Cited

  • Synbiotic Supplementation Containing Whole Plant Sugar Cane Fibre and Probiotic Spores Potentiates Protective Synergistic Effects in Mouse Model of IBD

    • 2019-04-11
    • Clinical Trial
    • Nutrients 11(4)
    • • Tanvi Shinde
      • A. P. Perera
      • R. Vemuri
      • Shakuntla V Gondalia
      • A. Karpe
      • D. Beale
      • Sonia Shastri
      • Benjamin Southam
      • R. Eri
      • R. Stanley

    • PubMed: 30979002
    • DOI: 10.3390/nu11040818

    3 Insights on

    • Reduced Disease Activity
    • Reduced Inflammatory Response
    • Increased Short Chain Fatty Acid Profiles

    • Low evidence
    • Animal Study

  • Dietary heat‐killed Lactobacillus brevis SBC8803 (SBL88™) improves hippocampus‐dependent memory performance and adult hippocampal neurogenesis

    • 2019-04-11
    • Clinical Trial
    • Neuropsychopharmacology Reports 39(2)
    • • Rie Ishikawa
      • H. Fukushima
      • Y. Nakakita
      • H. Kado
      • S. Kida

    • PubMed: 30977307
    • DOI: 10.1002/npr2.12054

    4 Insights on

    • Improved Delayed Memory
    • Improved Memory Performance
    • Enhanced Neurogenesis in Adults
    • Preserved Hippocampal Neurogenesis

    • High evidence
    • Rigorous Journal

  • Ameliorative effect of Bacillus subtilis, Saccharomyces boulardii, oregano, and calcium montmorillonite on growth, intestinal histology, and blood metabolites on Salmonella-infected broiler chicken

    • 2019-04-11
    • RCT · n = 600
    • Environmental Science and Pollution Research 26(16)
    • • A. Abudabos
      • Hemiar A A Alhouri
      • I. Alhidary
      • M. A. Nassan
      • A. Swelum

    • PubMed: 30977003
    • DOI: 10.1007/s11356-019-05105-1

    9 Insights on

    • Improved Gastrointestinal Health
    • Improved Intestinal Function
    • Improved Growth Performance
    • Increased Blood Glucose Levels
    • Improved Intestinal Histomorphology
    • Increased Villus Surface Area
    • Reduced Aspartate Aminotransferase Levels
    • Increased Blood Protein Levels
    • Improved Blood Glucose Concentration

    • Low evidence
    • Animal Study
• April 12

  • Lactobacillus plantarum KLDS1.0318 Ameliorates Impaired Intestinal Immunity and Metabolic Disorders in Cyclophosphamide-Treated Mice

    • 2019-04-12
    • RCT · n = 6
    • Frontiers in Microbiology 10
    • • Y. Meng
      • Jing Wang
      • Zhiyu Wang
      • Guofang Zhang
      • Libo Liu
      • G. Huo
      • Chun Li

    • PubMed: 31031723
    • DOI: 10.3389/fmicb.2019.00731

    10 Insights on

    • Improved Intestinal Morphology
    • Increased Short-Chain Fatty Acid Production
    • Improved Gut Microbiome Composition
    • Improved Short-Chain Fatty Acid Production
    • Improved Intestinal Microbial Composition
    • Increased Cytokine Secretion
    • Improved Intestinal Immune Response
    • Improved Metabolic Disorders
    • Improved Metabolic Profile
    • Improved Intestinal Metabolism

    • Low evidence
    • Animal Study
• April 15

  • Growth, health, rumen fermentation, and bacterial community of Holstein calves fed Lactobacillus rhamnosus GG during the preweaning stage1.

    • 2019-04-15
    • RCT · n = 24
    • Journal of Animal Science 97(6)
    • • Liyang Zhang
      • Xin Jiang
      • Xin Liu
      • Xue Zhao
      • Shuai Liu
      • Yang Li
      • Yonggen Zhang

    • PubMed: 30984974
    • DOI: 10.1093/jas/skz126

    4 Insights on

    • Improved Gut Bacterial Diversity
    • Increased Voluntary Starter Intake
    • Improved Fecal Score
    • Increased Beta-Hydroxybutyric Concentration

    • Low evidence
    • Rigorous Journal
    • Animal Study
• April 17

  • Bifidobacterium infantis Induces Protective Colonic PD-L1 and Foxp3 Regulatory T Cells in an Acute Murine Experimental Model of Inflammatory Bowel Disease

    • 2019-04-17
    • RCT · n = 5
    • Gut and Liver 13(4)
    • • Linyan Zhou
      • Dongyan Liu
      • Ying Xie
      • Xinjie Yao
      • Yan Li

    • PubMed: 30600673
    • DOI: 10.5009/gnl18316

    8 Insights on

    • Increased Body Weight
    • Reduced Colitis Symptoms
    • Increased IL-10 Levels
    • Improved Intestinal Epithelial Intercellular Integrity
    • Maintained Intestinal Immune Tolerance
    • Reduced Disease Activity Index Scores
    • Reduced Histological Damage Scores
    • Increased Foxp3 Protein Levels

    • Low evidence
    • Animal Study
• April 18

  • Intestinal Immunomodulation and Shifts on the Gut Microbiota of BALB/c Mice Promoted by Two Bifidobacterium and Lactobacillus Strains Isolated from Human Samples

    • 2019-04-18
    • BioMed Research International 2019
    • • A. Nogacka
      • S. Oddi
      • N. Salazar
      • J. Reinheimer
      • M. Gueimonde
      • G. Vinderola
      • C. G. de los Reyes-Gavilán

    • PubMed: 31119156
    • DOI: 10.1155/2019/2323540

    3 Insights on

    • Improved Immune Response
    • Increased Butyrate Production
    • Maintained Mucosa-Associated Immunity

    • Low evidence
    • Rigorous Journal
• April 19

  • Lactobacillus plantarum DR7 alleviates stress and anxiety in adults: a randomised, double-blind, placebo-controlled study.

    • 2019-04-19
    • RCT · n = 111
    • Beneficial Microbes 10(4)
    • • H. Chong
      • Nor Azizi Yusoff
      • Y. Hor
      • L. Lew
      • M. Jaafar
      • S. Choi
      • Muhamad Saiful Bahri Yusoff
      • N. Wahid
      • Mohammad Farris Iman Leong Bin Abdullah
      • Norzila Zakaria
      • Kee-Leong Ong
      • Y. Park
      • M. Liong

    • PubMed: 30882244
    • DOI: 10.3920/BM2018.0135

    16 Insights on

    • Increased Anti-Inflammatory Cytokine Levels
    • Reduced Pro-Inflammatory Cytokines
    • Improved Cognitive Function
    • Reduced Anxiety Levels
    • Reduced Anxiety Symptoms
    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Anxiety
    • Reduced Physical Symptoms of Stress
    • Improved Psychological Well-being
    • Reduced Plasma Cortisol Levels
    • Increased Plasma Anti-inflammatory Cytokine Levels
    • Enhanced Serotonin Pathway Function
    • Stabilized Dopamine Pathway Function
    • Reduced Cortisol Levels
    • Improved Psychological Distress
    • Reduced Stress

    • High evidence
    • Highly Cited

  • Effects of Bifidobacterium longum and Lactobacillus rhamnosus on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study

    • 2019-04-19
    • RCT · n = 23
    • Nutrients 11(4)
    • • Paola Vitellio
      • G. Celano
      • L. Bonfrate
      • M. Gobbetti
      • P. Portincasa
      • M. De Angelis

    • PubMed: 31010241
    • DOI: 10.3390/nu11040886

    4 Insights on

    • Improved Lactose Digestion
    • Reduced Constipation
    • Increased Levels of Beneficial Metabolites
    • Reduced Bloating Severity

    • High evidence

  • Lactobacillus fermentum and Lactobacillus plantarum increased gut microbiota diversity and functionality, and mitigated Enterobacteriaceae, in a mouse model.

    • 2019-04-19
    • RCT · n = 6
    • Beneficial Microbes 10(4)
    • • C. Linninge
      • J. Xu
      • M. I. Bahl
      • S. Ahrné
      • G. Molin

    • PubMed: 30957532
    • DOI: 10.3920/BM2018.0074

    4 Insights on

    • Improved Gut Microbiota Diversity
    • Reduced Enterobacteriaceae Counts
    • Reduced Inflammation Levels
    • Increased Short-Chain Fatty Acid Production

    • Low evidence
    • Animal Study

  • Lactobacillus rhamnosus GG can protect malnourished children.

    • 2019-04-19
    • RCT · n = 100
    • Beneficial Microbes 10(3)
    • • S. Kara
      • B. Volkan
      • I. Erten

    • PubMed: 30638398
    • DOI: 10.3920/BM2018.0071

    16 Insights on

    • Improved Nutritional Status
    • Reduced Upper Respiratory Tract Infection Days
    • Reduced Pathogen Infection
    • Reduced Hospitalization Rate
    • Reduced Upper Respiratory Infections
    • Reduced Incidence of Upper Respiratory Tract Infections
    • Reduced Incidence of Infections
    • Improved Body Mass Index
    • Reduced Infection Rate
    • Reduced Urinary Tract Infection Incidence
    • Reduced Human Infections
    • Reduced Incidence of Gastroenteritis
    • Increased Body Mass Index
    • Reduced Infection Incidence
    • Reduced Gastroenteritis Episode
    • Reduced Urinary Tract Infection

    • High evidence
• April 21

  • Effects of synbiotics containing Bifidobacterium animalis subsp. lactis GCL2505 and inulin on intestinal bifidobacteria: A randomized, placebo‐controlled, crossover study

    • 2019-04-21
    • RCT · n = 60
    • Food Science & Nutrition 7(5)
    • • D. Anzawa
      • Takashi Mawatari
      • Yoshiyuki Tanaka
      • Mio Yamamoto
      • Tomomi Genda
      • Shota Takahashi
      • Tomohiko Nishijima
      • H. Kamasaka
      • Satoru Suzuki
      • T. Kuriki

    • PubMed: 31139397
    • DOI: 10.1002/fsn3.1033

    7 Insights on

    • Increased Bifidobacteria Levels
    • Increased Fecal Bifidobacteria Levels
    • Improved Intestinal Microenvironment
    • Increased Levels of Bifidobacteria
    • Improved Intestinal Health
    • Increased Intestinal Bifidobacterium Levels
    • Increased Endogenous Bifidobacteria Levels

    • High evidence
• April 22

  • In Vitro Probiotic and Antioxidant Potential of Lactococcus lactis subsp. cremoris LL95 and Its Effect in Mice Behaviour

    • 2019-04-22
    • Nutrients 11(4)
    • • Juliana B Ramalho
      • Melina Bucco Soares
      • Cristiano Chiapinotto Spiazzi
      • D. F. Bicca
      • V. M. Soares
      • J. G. Pereira
      • W. P. da Silva
      • C. P. Sehn
      • F. Cibin

    • PubMed: 31013601
    • DOI: 10.3390/nu11040901

    3 Insights on

    • Reduced Depression Symptoms
    • Reduced Anxiety
    • Improved Antioxidant Activity

    • Moderate evidence

  • Supplementation with Lactobacillus reuteri ATCC PTA 4659 in patients affected by acute uncomplicated diverticulitis: a randomized double-blind placebo controlled trial

    • 2019-04-22
    • RCT · n = 88
    • International Journal of Colorectal Disease 34(6)
    • • C. Petruzziello
      • A. Migneco
      • S. Cardone
      • M. Covino
      • A. Saviano
      • F. Franceschi
      • V. Ojetti

    • PubMed: 31011868
    • DOI: 10.1007/s00384-019-03295-1

    3 Insights on

    • Reduced Hospitalization Duration
    • Reduced Abdominal Pain
    • Reduced Inflammatory Response

    • High evidence
    • Rigorous Journal
• April 25

  • Assessment of In Ovo Administration of Bifidobacterium bifidum and Bifidobacterium longum on Performance, Ileal Histomorphometry, Blood Hematological, and Biochemical Parameters of Broilers

    • 2019-04-25
    • RCT · n = 300
    • Probiotics and Antimicrobial Proteins 12(2)
    • • A. El-Moneim
      • I. El-Wardany
      • A. M. Abu-Taleb
      • M. Wakwak
      • T. Ebeid
      • A. Saleh

    • PubMed: 31025259
    • DOI: 10.1007/s12602-019-09549-2

    8 Insights on

    • Improved Body Weight
    • Improved Growth Performance
    • Improved Intestinal Development
    • Increased Villus Height
    • Enhanced Ileal Development
    • Unchanged Biochemical Parameters
    • Improved Ileal Histomorphometry
    • No Significant Change in Blood Indices

    • Low evidence
    • Animal Study

  • Effect of Encapsulated Lactobacillus bulgaricus on Innate Immune System and Hematological Parameters in Rainbow Trout (Oncorhynchus mykiss), Post-Administration of Pb

    • 2019-04-25
    • RCT · n = 240
    • Probiotics and Antimicrobial Proteins 12(2)
    • • T. Mohammadian
      • Z. T. Dezfuly
      • Reza Ghanei Motlagh
      • A. Jangaran-Nejad
      • S. S. Hosseini
      • H. Khaj
      • N. Alijani

    • PubMed: 31025260
    • DOI: 10.1007/s12602-019-09544-7

    14 Insights on

    • Increased Serum Lysozyme Activity
    • Reduced Toxicity
    • Increased Hemoglobin Levels
    • Increased Red Blood Cell Count
    • Enhanced Complement Pathway Activity
    • Increased White Blood Cell Count
    • Enhanced Bactericidal Activity
    • Increased Respiratory Burst Activity
    • Reduced Hemoglobin Level
    • Reduced Red Blood Cell Count
    • Reduced White Blood Cells After Lead Exposure
    • Reduced Respiratory Burst Activity
    • Reduced Blood Parameters Post Lead Exposure
    • Reduced Heavy Metal Toxicity

    • Low evidence
    • Animal Study
• April 27

  • Nasal Priming with Lactobacillus rhamnosus CRL1505 Stimulates Mononuclear Phagocytes of Immunocompromised Malnourished Mice: Improvement of Respiratory Immune Response

    • 2019-04-27
    • Probiotics and Antimicrobial Proteins 12(2)
    • • N. Barbieri
      • S. Salva
      • M. Herrera
      • J. Villena
      • S. Alvarez

    • PubMed: 31030404
    • DOI: 10.1007/s12602-019-09551-8

    2 Insights on

    • Increased Post-Infection Lung Monocyte Levels
    • Improved Pneumococcal Infection Outcomes

    • Low evidence
• April 30

  • Dietary Heat-Killed Lactobacillus brevis SBC8803 Attenuates Chronic Sleep Disorders Induced by Psychophysiological Stress in Mice.

    • 2019-04-30
    • Clinical Trial
    • Journal of Nutritional Science and Vitaminology 65(2)
    • • Sayaka Higo-Yamamoto
      • Saori Yamamoto
      • K. Miyazaki
      • Y. Nakakita
      • H. Kaneda
      • Y. Takata
      • Takeshi Nakamura
      • K. Oishi

    • PubMed: 31061285
    • DOI: 10.3177/jnsv.65.164

    9 Insights on

    • Improved Circadian Rhythm
    • Increased Wakefulness
    • Improved NREM Sleep Intensity
    • Reduced Insomnia
    • Improved Sleep Quality
    • Reduced Circadian Sleep Disturbance
    • Increased NREM Sleep
    • Preserved Wheel-Running Activity
    • Reduced Stress-Induced Sleep Disruption

    • Low evidence
    • Animal Study
• Undated – 2 supplement studies

  • Dietary supplementation of probiotic Bacillus coagulans ATCC 7050, improves the growth performance, intestinal morphology, microflora, immune response, and disease confrontation of Pacific white shrimp, Litopenaeus vannamei

    • 2019-04
    • Fish & Shellfish Immunology 87
    • • K. Amoah
      • Qin-Cheng Huang
      • B. Tan
      • Shuang Zhang
      • S. Chi
      • Qi‐hui Yang
      • Hongyu Liu
      • Xiao‐hui Dong

    • PubMed: 30790661
    • DOI: 10.1016/j.fsi.2019.02.029

    18 Insights on

    • Improved Intestinal Morphology
    • Improved Immune Response
    • Reduced Triglyceride Levels
    • Improved Growth Performance
    • Enhanced Disease Resistance
    • Improved Feed Utilization
    • Enhanced Digestive Enzyme Activity
    • Reduced Oxidative Stress
    • Reduced Lipid Peroxidation
    • Improved Microflora Composition
    • Enhanced Immune Resistance
    • Reduced Pathogenic Bacterial Abundance
    • Reduced Harmful Gut Microbiota
    • Improved Beneficial Intestinal Bacteria
    • Improved Resistance to Infections
    • Improved Digestive Enzyme Activity
    • Improved Resistance to Pathogenic Infection
    • Reduced Opportunistic Pathogenic Bacteria Levels

    • Low evidence
    • Highly Cited

  • Additive effect of Lactobacillus acidophilus L-92 on children with atopic dermatitis concomitant with food allergy

    • 2019-04
    • RCT · n = 59
    • Asia Pacific Allergy 9(2)
    • • Joan Nakata
      • Tatsuhiko Hirota
      • Harue Umemura
      • T. Nakagawa
      • N. Kando
      • M. Futamura
      • Yasunori Nakamura
      • Komei Ito

    • PubMed: 31089460
    • DOI: 10.5415/apallergy.2019.9.e18

    7 Insights on

    • Improved Atopic Dermatitis Severity
    • Reduced Total IgE Levels
    • Reduced SCORAD Index
    • Improved Allergic Inflammation Markers
    • Reduced Eczema Severity
    • Reduced Thymus and Activation-Regulated Chemokine Level
    • Reduced Immunoglobulin E Level

    • High evidence
    • Rigorous Journal