May 2020 Supplement Research Papers

• May 3

  • Pediococcus pentosaceus LI05 alleviates DSS‐induced colitis by modulating immunological profiles, the gut microbiota and short‐chain fatty acid levels in a mouse model

    • 2020-05-03
    • Clinical Trial
    • Microbial Biotechnology 13(4)
    • • Xiaoyuan Bian
      • Liya Yang
      • Wen-rui Wu
      • L. Lv
      • Xianwan Jiang
      • Qing Wang
      • Jingjing Wu
      • Yating Li
      • Jianzhong Ye
      • D. Fang
      • D. Shi
      • Kaicen Wang
      • Qiangqiang Wang
      • Yanmeng Lu
      • Jiaojiao Xie
      • Jiafeng Xia
      • Lanjuan Li

    • PubMed: 32363766
    • DOI: 10.1111/1751-7915.13583

    8 Insights on

    • Improved Gut Microbiota Diversity
    • Improved Intestinal Barrier Function
    • Reduced Colitis Symptoms
    • Increased SCFA Levels
    • Increased Short-Chain Fatty Acid Production
    • Improved Gut Microbiome Composition
    • Modulated Immunological Profile
    • Improved Intestinal Epithelial Intercellular Integrity

    • Low evidence
    • Animal Study
• May 6

  • Effect of Yogurt Fermented by Lactobacillus Fermentum TSI and L. Fermentum S2 Derived from a Mongolian Traditional Dairy Product on Rats with High-Fat-Diet-Induced Obesity

    • 2020-05-06
    • Foods 9(5)
    • • Won-Young Cho
      • Go-Eun Hong
      • Ha-Jung Lee
      • Su-Jung Yeon
      • H. Paik
      • Y. Hosaka
      • Chi-Ho Lee

    • PubMed: 32384659
    • DOI: 10.3390/foods9050594

    2 Insights on

    • Reduced Abdominal Fat
    • Improved Lipid Metabolism

    • Low evidence
    • Rigorous Journal
• May 8

  • Effect of oral consumption of capsules containing Lactobacillus paracasei LPC-S01 on the vaginal microbiota of healthy adult women: a randomized, placebo-controlled, double-blind crossover study

    • 2020-05-08
    • RCT · n = 40
    • FEMS Microbiology Ecology 96(6)
    • • R. Koirala
      • G. Gargari
      • S. Arioli
      • Valentina Taverniti
      • W. Fiore
      • E. Grossi
      • G. Anelli
      • I. Cetin
      • S. Guglielmetti

    • PubMed: 32383767
    • DOI: 10.1093/femsec/fiaa084

    4 Insights on

    • Improved Vaginal Microbial Pattern
    • Reduced Gardnerella Vaginosis Prevalence
    • Reduced Gardnerella spp. Abundance
    • Reduced Gardnerella Vaginalis Abundance

    • High evidence
    • Rigorous Journal
• May 11

  • Bifidobacterium breve M‐16V alters the gut microbiota to alleviate OVA‐induced food allergy through IL‐33/ST2 signal pathway

    • 2020-05-11
    • Clinical Trial
    • Journal of Cellular Physiology 235(12)
    • • Na Li
      • Yi Yu
      • Xue-hua Chen
      • Shenshen Gao
      • Qingqing Zhang
      • Chundi Xu

    • PubMed: 32394447
    • DOI: 10.1002/jcp.29751

    1 Insight on

    • Reduced Food Allergy Symptoms

    • Low evidence
    • Animal Study

  • Effects of Lactobacillus fermentum CECT5716 Lc40 on infant growth and health: a randomised clinical trial in nursing women.

    • 2020-05-11
    • RCT · n = 291
    • Beneficial Microbes 11(3)
    • • B. Pastor-Villaescusa
      • J. Hurtado
      • M. Gil-Campos
      • J. Uberos
      • J. Maldonado-Lobón
      • M. Díaz-Ropero
      • O. Bañuelos
      • J. Fonollá
      • M. Olivares

    • PubMed: 32216468
    • DOI: 10.3920/BM2019.0180

    3 Insights on

    • Reduced Incidence of Conjunctivitis in Infants
    • Increased Weight Z-Score in Infants
    • Reduced Respiratory Infections in Infants

    • High evidence

  • Synergistic effect of Lactobacillus gasseri and Cudrania tricuspidata on the modulation of body weight and gut microbiota structure in diet-induced obese mice

    • 2020-05-11
    • Clinical Trial
    • Applied Microbiology and Biotechnology 104(14)
    • • J. Oh
      • M. B. Amoranto
      • N. Oh
      • Sejeong Kim
      • J. Lee
      • Y. Oh
      • Y. Shin
      • Y. Yoon
      • D. Kang

    • PubMed: 32394142
    • DOI: 10.1007/s00253-020-10634-8

    3 Insights on

    • Reduced Body Weight
    • Increased Microbial Diversity
    • Reduced Helicobacter Abundance

    • Low evidence
    • Animal Study
• May 13

  • Leuconostoc mesenteroides fermentation produces butyric acid and mediates Ffar2 to regulate blood glucose and insulin in type 1 diabetic mice

    • 2020-05-13
    • Clinical Trial
    • Scientific Reports 10(1)
    • • S. Traisaeng
      • Anir Batsukh
      • T. Chuang
      • D. Herr
      • Yu‐Fen Huang
      • Battogtokh Chimeddorj
      • Chun-Ming Huang

    • PubMed: 32404878
    • DOI: 10.1038/s41598-020-64916-2

    3 Insights on

    • Reduced Interleukin-6 Levels
    • Reduced Blood Glucose Levels
    • Elevated Insulin Levels

    • Low evidence
    • Rigorous Journal
    • Animal Study
• May 18

  • Oral galactagogues (natural therapies or drugs) for increasing breast milk production in mothers of non-hospitalised term infants.

    • 2020-05-18
    • Meta-Analysis · n = 3,006
    • The Cochrane database of systematic reviews 2020(5)
    • • Siew Cheng Foong
      • May Loong Tan
      • Wai Cheng Foong
      • Lisa A Marasco
      • Jacqueline J Ho
      • Joo Howe Ong

    • PubMed: 32421208
    • DOI: 10.1002/14651858.cd011505.pub2

    2 Insights on

    • Increased Infant Weight
    • Increased Milk Volume

    • High evidence

  • Lipophilic 9,10-Dehydrofukinone Action on Pathogenic and Non-Pathogenic Bacterial Biofilms. Why Is This Main Volatile Metabolite in Senecio?

    • 2020-05-18
    • Chemistry & biodiversity 17(6)
    • • María C Verni
      • José A Garay
      • Lucía Mendoza
      • Alicia Bardón
      • Susana Borkosky
      • Mario E Arena
      • Elena Cartagena

    • PubMed: 32277597
    • DOI: 10.1002/cbdv.201900507

    1 Insight on

    • Increased Surface Activity

    • Low evidence
• May 19

  • Effect of Supplementation with Saccharomyces Boulardii on Academic Examination Performance and Related Stress in Healthy Medical Students: A Randomized, Double-Blind, Placebo-Controlled Trial

    • 2020-05-19
    • RCT · n = 50
    • Nutrients 12(5)
    • • M. Karbownik
      • Joanna Kręczyńska
      • Paulina Kwarta
      • M. Cybula
      • A. Wiktorowska-Owczarek
      • E. Kowalczyk
      • T. Pietras
      • J. Szemraj

    • PubMed: 32438624
    • DOI: 10.3390/nu12051469

    1 Insight on

    • Elevated Pulse Rate Under Stress

    • High evidence

  • An Infant Milk Formula Supplemented with Heat-Treated Probiotic Bifidobacterium animalis subsp. lactis CECT 8145, Reduces Fat Deposition in C. elegans and Augments Acetate and Lactate in a Fermented Infant Slurry

    • 2020-05-19
    • Clinical Trial
    • Foods 9(5)
    • • Ángela Silva
      • Núria González
      • A. Terren
      • Antonio G. García
      • J. Martínez-Blanch
      • Vanessa Illescas
      • Javier Morales
      • Marcos Maroto
      • S. Genovés
      • D. Ramón
      • P. Martorell
      • E. Chenoll

    • PubMed: 32438563
    • DOI: 10.3390/foods9050652

    4 Insights on

    • Increased Fecal Acetate Levels
    • Enhanced SCFA Production
    • Reduced Fat Accumulation
    • Elevated Lactate Levels

    • Low evidence
    • Rigorous Journal
    • Animal Study
• May 25

  • Fermentation Improves Calcium Bioavailability in Moringa oleifera leaves and Prevents Bone Loss in Calcium-deficient Rats.

    • 2020-05-25
    • Clinical Trial
    • Food science & nutrition 8(7)
    • • Jiahe Dai
      • Liang Tao
      • Chongyin Shi
      • Shuwen Yang
      • Depeng Li
      • Jun Sheng
      • Yang Tian

    • PubMed: 32724632
    • DOI: 10.1002/fsn3.1653

    4 Insights on

    • Improved Calcium Absorption
    • Reduced Bone Erosion
    • Reduced Bone Loss
    • Increased Total Hip Bone Mineral Density

    • Moderate evidence
• May 27

  • Effect of Gymnema sylvestre Administration on Glycemic Control, Insulin Secretion, and Insulin Sensitivity in Patients with Impaired Glucose Tolerance.

    • 2020-05-27
    • RCT · n = 30
    • Journal of medicinal food 24(1)
    • • Luis A Gaytán Martínez
      • Luis A Sánchez-Ruiz
      • Laura Y Zuñiga
      • Manuel González-Ortiz
      • Esperanza Martínez-Abundis

    • PubMed: 32460589
    • DOI: 10.1089/jmf.2020.0024

    7 Insights on

    • Improved Insulin Sensitivity
    • Reduced Body Mass Index
    • Reduced Low-Density Lipoprotein Level
    • Reduced Body Weight
    • Reduced Blood Glucose Level
    • Reduced Glycated Hemoglobin A1c Level
    • Increased Proportion with Normalized Hemoglobin A1c

    • High evidence
• May 28

  • Bifidobacterium longum Subspecies infantis (B. infantis) in Pediatric Nutrition: Current State of Knowledge

    • 2020-05-28
    • Nutrients 12(6)
    • • M. Chichlowski
      • N. Shah
      • J. Wampler
      • Steven S. Wu
      • J. Vanderhoof

    • PubMed: 32481558
    • DOI: 10.3390/nu12061581

    5 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Inflammatory Response
    • Increased Production of Acetate
    • Reduced Inflammation
    • Accelerated Immune Response Maturation

    • Moderate evidence
• Undated – 8 supplement studies

  • Towards a psychobiotic therapy for depression: Bifidobacterium breve CCFM1025 reverses chronic stress-induced depressive symptoms and gut microbial abnormalities in mice

    • 2020-05
    • Clinical Trial
    • Neurobiology of Stress 12
    • • Peijun Tian
      • Kenneth J. O'Riordan
      • Yuan-Kun Lee
      • Gang Wang
      • Jianxin Zhao
      • Hao Zhang
      • J. Cryan
      • Wei Chen

    • PubMed: 32258258
    • DOI: 10.1016/j.ynstr.2020.100216

    6 Insights on

    • Increased Short-Chain Fatty Acid Levels
    • Reduced Inflammation Levels
    • Enhanced Brain-Derived Neurotrophic Factor Levels
    • Improved HPA Axis Response
    • Normalized Gut Microbiota
    • Increased 5-Hydroxytryptophan Levels

    • Low evidence
    • Highly Cited
    • Animal Study

  • Synbiotic Alters Fecal Microbiomes, but not Liver Fat or Fibrosis, in a Randomized Trial of Patients With Non-alcoholic Fatty Liver Disease.

    • 2020-05
    • RCT · n = 104
    • Gastroenterology 158(6)
    • • E. Scorletti
      • P. Afolabi
      • E. Miles
      • Debbie E. Smith
      • Amal Almehmadi
      • Albandri Alshathry
      • C. Childs
      • S. Del Fabbro
      • Josh Bilson
      • H. Moyses
      • G. Clough
      • Jaswinder K. Sethi
      • J. Patel
      • M. Wright
      • D. Breen
      • C. Peebles
      • A. Darekar
      • R. Aspinall
      • A. Fowell
      • J. Dowman
      • V. Nobili
      • G. Targher
      • N. Delzenne
      • L. Bindels
      • P. Calder
      • C. Byrne

    • PubMed: 31987796
    • DOI: 10.1053/j.gastro.2020.01.031

    2 Insights on

    • Reduced Liver Fat Content
    • Changes in Liver Fibrosis Markers

    • High evidence
    • Highly Cited

  • Structural characterization and immunomodulatory activity of an exopolysaccharide produced by Lactobacillus helveticus LZ-R-5.

    • 2020-05
    • Carbohydrate Polymers 235
    • • Xiu You
      • Zhi Li
      • Kai Ma
      • Changliang Zhang
      • Xiaohong Chen
      • Guangxian Wang
      • Lin Yang
      • Mingsheng Dong
      • X. Rui
      • Qiuqin Zhang
      • Wei Li

    • PubMed: 32122508
    • DOI: 10.1016/j.carbpol.2020.115977

    1 Insight on

    • Improved Immune Response

    • Low evidence

  • Inhibitory effect of Bifidobacterium bifidum ATCC 29521 on colitis and its mechanism.

    • 2020-05
    • RCT · n = 7
    • The Journal of Nutritional Biochemistry 79
    • • A. U. Din
      • Adil Hassan
      • Yuan Zhu
      • Kun Zhang
      • Yi Wang
      • Tianhan Li
      • Yang Wang
      • Guixue Wang

    • PubMed: 32145470
    • DOI: 10.1016/j.jnutbio.2020.108353

    15 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Inflammatory Response
    • Reduced Ulcerative Colitis Symptoms
    • Reduced Colitis Symptoms
    • Enhanced Tight Junction Integrity
    • Reduced Colonic Inflammation
    • Reduced Inflammation Levels
    • Improved Gut Microbiota Balance
    • Restored Healthy Gut Microbial Balance
    • Restored Normal Microbiota
    • Restored Intestinal Barrier Function
    • Improved Antioxidant Defense
    • Restored Gut Microbiome Balance
    • Restored Microbial Balance
    • Reduced Colitis Inflammation

    • Low evidence
    • Animal Study

  • Lactobacillus rhamnosus GG Attenuates Lipopolysaccharide-Induced Inflammation and Barrier Dysfunction by Regulating MAPK/NF-κB Signaling and Modulating Metabolome in the Piglet Intestine.

    • 2020-05
    • RCT · n = 6
    • The Journal of Nutrition 150(5)
    • • Jiangdi Mao
      • Siri Qi
      • Yanjun Cui
      • Xiaoxiao Dou
      • Xin M. Luo
      • Jianxin Liu
      • T. Zhu
      • Yanfei Ma
      • Haifeng Wang

    • PubMed: 32027752
    • DOI: 10.1093/jn/nxaa009

    9 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Inflammatory Response
    • Reduced Intestinal Inflammation
    • Reduced Inflammation Levels
    • Modulated Metabolite Profile
    • Reduced Gut Inflammation
    • Modulated Intestinal Metabolite Profile
    • Improved Metabolic Profile
    • Altered Metabolite Profile

    • Low evidence
    • Animal Study

  • Lactobacillus paracasei as a protective factor of obesity induced by an unhealthy diet in children.

    • 2020-05
    • Observational · n = 1,111
    • Obesity Research & Clinical Practice 14(3)
    • • A. C. Castañeda-Márquez
      • C. E. Díaz-Benítez
      • M. Bahena-Román
      • Guadalupe Evelin Campuzano-Benítez
      • Marcia V Galván-Portillo
      • J. Campuzano-Rincón
      • A. Lagunas-Martínez
      • V. Bermúdez-Morales
      • Y. C. Orbe-Orihuela
      • Jesús Peralta-Romero
      • M. Cruz
      • A. Burguete-García

    • PubMed: 32518007
    • DOI: 10.1016/j.orcp.2020.04.005

    1 Insight on

    • Reduced Obesity

    • High evidence

  • A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial.

    • 2020-05
    • RCT · n = 80
    • Digestive and Liver Disease 52(5)
    • • S. Sadrin
      • S. Sennoune
      • B. Gout
      • S. Marque
      • J. Moreau
      • Karim Zinoune
      • J. Grillasca
      • O. Pons
      • J. Maixent

    • PubMed: 31952938
    • DOI: 10.1016/j.dld.2019.12.009

    13 Insights on

    • Reduced Abdominal Pain Severity
    • Reduced Flatulence
    • Reduced Abdominal Pain
    • Reduced Composite Score
    • Improved Gastrointestinal Symptoms
    • Improved Abdominal Pain
    • Improved IBS Composite Symptom Score
    • Reduced Composite Symptom Score
    • Improved Flatus
    • Improved Gastrointestinal Symptom Score
    • Improved Composite Score of Irritable Bowel Syndrome Symptoms
    • Decreased Composite Scores
    • Improved Gastrointestinal Score

    • High evidence

  • S-layer protein 2 of Lactobacillus crispatus 2029, its structural and immunomodulatory characteristics and roles in protective potential of the whole bacteria against foodborne pathogens.

    • 2020-05
    • International Journal of Biological Macromolecules 150
    • • V. Abramov
      • I. Kosarev
      • T. Priputnevich
      • A. Machulin
      • V. Khlebnikov
      • S. Pchelintsev
      • R. Vasilenko
      • V. Sakulin
      • N. Suzina
      • I. Chikileva
      • Evgenia I Derysheva
      • V. Melnikov
      • I. N. Nikonov
      • V. A. Samoilenko
      • Eduard E Svetoch
      • G. Sukhikh
      • V. Uversky
      • A. V. Karlyshev

    • PubMed: 32045605
    • DOI: 10.1016/j.ijbiomac.2020.02.065

    16 Insights on

    • Reduced Pro-inflammatory Cytokine Levels
    • Enhanced Anti-inflammatory Response
    • Reduced Proinflammatory Cytokine Production
    • Reduced Pathogen Adhesion
    • Reduced Pathogen Activity
    • Non-toxicity to Cervicovaginal Epithelial Cells
    • Improved Intestinal Cell Viability
    • Interaction with Immune Cells Without Inflammation
    • Enhanced Anti-Inflammatory Cytokine Production
    • Reduced Apoptosis Induced by Pathogens
    • Enhanced Adhesion of Beneficial Bacteria
    • Increased Anti-Inflammatory Cytokine IL-6 Production
    • Improved Colonization Resistance
    • Improved Adhesion of Bifidobacteria
    • Inhibited Activation of Apoptotic Biomarkers
    • Reduced Foodborne Pathogen Load

    • Low evidence