Skip to main content

Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Effects of dietary Clostridium butyricum supplementation on growth performance, intestinal development, and immune response of weaned piglets challenged with lipopolysaccharide
- 2018-08-23
- RCT
- Journal of Animal Science and Biotechnology 9(1)
- - Ling Chen
  - Shuang Li
  - Jie Zheng
  - Wentao Li
  - Xuemei Jiang
  - Xilun Zhao
  - Jian Li
  - L. Che
  - Yan Lin
  - Shengyu Xu
  - B. Feng
  - Z. Fang
  - De Wu
- PubMed: 30159141
- DOI: 10.1186/s40104-018-0275-8
5 Insights on
- High evidence
- Highly Cited
- Rigorous Journal
New perspectives of Lactobacillus plantarum as a probiotic: The gut-heart-brain axis
- 2018-08-23
- Journal of Microbiology 56(9)
- - Yen-Wenn Liu
  - M. Liong
  - Y. Tsai
- PubMed: 30141154
- DOI: 10.1007/s12275-018-8079-2
7 Insights on
- Low evidence
- Highly Cited
Functional Properties of Food Origin Lactobacillus in the Gastrointestinal Ecosystem—In Vitro Study
- 2018-08-23
- Probiotics and Antimicrobial Proteins 11(3)
- - D. Zielińska
  - E. Długosz
  - A. Zawistowska-Deniziak
- PubMed: 30141062
- DOI: 10.1007/s12602-018-9458-z
5 Insights on
- Low evidence
Effects of a combination of Nigella sativa and Vitex agnus-castus with citalopram on healthy menopausal women with hot flashes: results from a subpopulation analysis.
- 2018-08-21
- RCT · n = 46
- Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 35(1)
- - Maryam Molaie
  - Behrad Darvishi
  - Zahra Jafari Azar
  - Mahboobeh Shirazi
  - Gholamreza Amin
  - Shima Afshar
- PubMed: 30129806
- DOI: 10.1080/09513590.2018.1499086
4 Insights on
- High evidence
Mutation of the Surface Layer Protein SlpB Has Pleiotropic Effects in the Probiotic Propionibacterium freudenreichii CIRM-BIA 129
- 2018-08-17
- Frontiers in Microbiology 9
- - F. L. R. do Carmo
  - W. M. Silva
  - G. C. Tavares
  - I. Ibraim
  - B. F. Cordeiro
  - E. Oliveira
  - Houem Rabah
  - C. Cauty
  - S. H. da Silva
  - M. V. Canário Viana
  - A. Caetano
  - R. G. Dos Santos
  - R. D. de Oliveira Carvalho
  - J. Jardin
  - Felipe L. Pereira
  - E. Folador
  - Y. Le Loir
  - H. Figueiredo
  - G. Jan
  - V. Azevedo
- PubMed: 30174657
- DOI: 10.3389/fmicb.2018.01807
1 Insight on
- Healed Colitis
- Low evidence
Effect of probiotic Bifidobacterium bifidum G9-1 on the relationship between gut microbiota profile and stress sensitivity in maternally separated rats
- 2018-08-17
- Clinical Trial
- Scientific Reports 8(1)
- - H. Fukui
  - T. Oshima
  - Yoshiki Tanaka
  - Yosuke Oikawa
  - Yutaka Makizaki
  - H. Ohno
  - T. Tomita
  - J. Watari
  - H. Miwa
- PubMed: 30120330
- DOI: 10.1038/s41598-018-30943-3
3 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
A Review of Prebiotics Against Salmonella in Poultry: Current and Future Potential for Microbiome Research Applications.
- 2018-08-15
- Review
- Frontiers in veterinary science 5
- - Andrew C Micciche
  - Steven L Foley
  - Hilary O Pavlidis
  - Donald R McIntyre
  - Steven C Ricke
- PubMed: 30159318
- DOI: 10.3389/fvets.2018.00191
4 Insights on
- Low evidence
Lactobacillus sakei WIKIM30 Ameliorates Atopic Dermatitis-Like Skin Lesions by Inducing Regulatory T Cells and Altering Gut Microbiota Structure in Mice
- 2018-08-14
- Clinical Trial
- Frontiers in Immunology 9
- - Min-Sung Kwon
  - S. Lim
  - J. Jang
  - Jieun Lee
  - Hyo Kyeong Park
  - Namhee Kim
  - M. Yun
  - Miyoung Shin
  - Hee Eun Jo
  - Young Joon Oh
  - S. Roh
  - Hak-Jong Choi
- PubMed: 30154801
- DOI: 10.3389/fimmu.2018.01905
2 Insights on
- Reduced Atopic Dermatitis Severity
- Improved Gut Microbiota with Reversal of Alzheimer’s Disease-related Changes
- Low evidence
- Highly Cited
- Animal Study
The Use of Two Bifidobacterium Strains Enhanced Growth Performance and Nutrient Utilization of Rainbow Trout (Oncorhynchus mykiss) Fry
- 2018-08-14
- RCT · n = 480
- Probiotics and Antimicrobial Proteins 11(3)
- - J. Sahandi
  - H. Jafaryan
  - M. Soltani
  - P. Ebrahimi
- PubMed: 30109493
- DOI: 10.1007/s12602-018-9455-2
2 Insights on
- Improved Growth Performance
- Enhanced Nutrient Utilization
- Low evidence
- Animal Study
Bacillus clausii for the Treatment of Acute Diarrhea in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- 2018-08-12
- Meta-Analysis
- Nutrients 10(8)
- - G. Ianiro
  - G. Rizzatti
  - Manuel Plomer
  - L. Lopetuso
  - F. Scaldaferri
  - F. Franceschi
  - G. Cammarota
  - A. Gasbarrini
- PubMed: 30103531
- DOI: 10.3390/nu10081074
3 Insights on
- High evidence
Evaluation of the Impacts of Long-Term Enriched Artemia with Bacillus subtilis on Growth Performance, Reproduction, Intestinal Microflora, and Resistance to Aeromonas hydrophila of Ornamental Fish Poecilia latipinna
- 2018-08-10
- RCT
- Probiotics and Antimicrobial Proteins 11(3)
- - N. Ahmadifard
  - Vahid Rezaei Aminlooi
  - A. Tukmechi
  - N. Agh
- PubMed: 30097884
- DOI: 10.1007/s12602-018-9453-4
7 Insights on
- High evidence
The effect of vitamin D2 supplementation on muscle strength in early postmenopausal women: a randomized, double-blind, placebo-controlled trial.
- 2018-08-10
- RCT · n = 88
- Climacteric : the journal of the International Menopause Society 21(5)
- - C Suebthawinkul
  - K Panyakhamlerd
  - P Yotnuengnit
  - A Suwan
  - N Chaiyasit
  - N Taechakraichana
- PubMed: 30095022
- DOI: 10.1080/13697137.2018.1480600
3 Insights on
- High evidence
The Probiotic Lactobacillus fermentum Prevents Dysbiosis and Vascular Oxidative Stress in Rats with Hypertension Induced by Chronic Nitric Oxide Blockade
- 2018-08-07
- RCT · n = 4
- Molecular Nutrition & Food Research 62(19)
- - Iñaki Robles‐Vera
  - M. Toral
  - Néstor de la Visitación
  - M. Sánchez
  - M. Romero
  - M. Olivares
  - R. Jiménez
  - J. Duarte
- PubMed: 30028078
- DOI: 10.1002/mnfr.201800298
5 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands.
- 2018-08-06
- Meta-Analysis
- BMC gastroenterology 18(1)
- - Valeria Agamennone
  - Cyrille A M Krul
  - Ger Rijkers
  - Remco Kort
- PubMed: 30078376
- DOI: 10.1186/s12876-018-0831-x
1 Insight on
- Reduced Antibiotic-Associated Diarrhea
- High evidence
Effect of Lactobacillus salivarius on growth performance, diarrhea incidence, fecal bacterial population and intestinal morphology of suckling pigs challenged with F4+ enterotoxigenic Escherichia coli
- 2018-08-01
- RCT · n = 201
- Asian-Australasian Journal of Animal Sciences 31(8)
- - Harutai Sayan
  - P. Assavacheep
  - Kris Angkanaporn
  - Anongnart Assavacheep
- PubMed: 29642683
- DOI: 10.5713/ajas.17.0746
5 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Effect of Lactobacillus rhamnosus GG Supplementation on Intestinal Inflammation Assessed by PET/MRI Scans and Gut Microbiota Composition in HIV-Infected Individuals.
- 2018-08-01
- Clinical Trial · n = 45
- Journal of acquired immune deficiency syndromes (1999) 78(4)
- - Caroline J Arnbjerg
  - Beate Vestad
  - Johannes R Hov
  - Karin K Pedersen
  - Sofie Jespersen
  - Helle H Johannesen
  - Kristian Holm
  - Bente Halvorsen
  - Eva Fallentin
  - Adam E Hansen
  - Theis Lange
  - Andreas Kjær
  - Marius Trøseid
  - Barbara M Fischer
  - Susanne D Nielsen
- PubMed: 29874201
- DOI: 10.1097/qai.0000000000001693
11 Insights on
- High evidence
Protective effect of Lactobacillus reuteri DSM 17938 against experimental necrotizing enterocolitis is mediated by Toll-like receptor 2.
- 2018-08-01
- RCT
- American Journal of Physiology-Gastrointestinal and Liver Physiology 315(2)
- - T. Hoang
  - Baokun He
  - Ting Wang
  - D. Tran
  - J. M. Rhoads
  - Yuying Liu
- PubMed: 29648878
- DOI: 10.1152/ajpgi.00084.2017
10 Insights on
- Low evidence
- Animal Study
Effect of Bifidobacterium lactis HN019 on inflammatory markers and oxidative stress in subjects with and without the metabolic syndrome
- 2018-07-30
- Clinical Trial · n = 33
- British Journal of Nutrition 120(6)
- - L. J. Bernini
  - A. Simão
  - C. H. B. de Souza
  - D. Alfieri
  - L. Segura
  - G. N. Costa
  - I. Dichi
- PubMed: 30058513
- DOI: 10.1017/S0007114518001861
6 Insights on
- High evidence
Effects of Probiotic (Bacillus subtilis DE111) Supplementation on Immune Function, Hormonal Status, and Physical Performance in Division I Baseball Players
- 2018-07-26
- RCT · n = 25
- Sports 6(3)
- - Jeremy R. Townsend
  - David Bender
  - William C. Vantrease
  - Philip A. Sapp
  - Ann M. Toy
  - Clint A Woods
  - Kent D. Johnson
- PubMed: 30049931
- DOI: 10.3390/sports6030070
1 Insight on
- Reduced TNF-α Concentration
- High evidence
Characterization of Mucus-Related Properties of Streptococcus thermophilus: From Adhesion to Induction
- 2018-07-24
- Frontiers in Physiology 9
- - N. Fernandez
  - Laura Wrzosek
  - J. M. Radziwill-Bienkowska
  - B. Ringot-Destrez
  - M. Duviau
  - Marie‐Louise Noordine
  - V. Laroute
  - V. Robert
  - C. Cherbuy
  - M. Daveran-Mingot
  - M. Cocaign-Bousquet
  - R. Léonard
  - C. Robbe-Masselot
  - F. Rul
  - E. Ogier-Denis
  - Muriel Thomas
  - M. Mercier-Bonin
- PubMed: 30087622
- DOI: 10.3389/fphys.2018.00980
6 Insights on
- Low evidence
The Acute and Chronic Cognitive and Cerebral Blood Flow Effects of a Sideritis scardica (Greek Mountain Tea) Extract: A Double Blind, Randomized, Placebo Controlled, Parallel Groups Study in Healthy Humans.
- 2018-07-24
- RCT
- Nutrients 10(8)
- - Emma L Wightman
  - Philippa A Jackson
  - Julie Khan
  - Joanne Forster
  - Felix Heiner
  - Bjoern Feistel
  - Cynthia G Suarez
  - Ivo Pischel
  - David O Kennedy
- PubMed: 30042362
- DOI: 10.3390/nu10080955
8 Insights on
- High evidence
- Rigorous Journal
Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo‐controlled, double‐blind, clinical trial
- 2018-07-22
- RCT
- Journal of Internal Medicine 284(3)
- - Anna G. Nilsson
  - Anna G. Nilsson
  - D. Sundh
  - Fredrik Bäckhed
  - Fredrik Bäckhed
  - M. Lorentzon
  - M. Lorentzon
- PubMed: 29926979
- DOI: 10.1111/joim.12805
1 Insight on
- Reduced Bone Loss
- High evidence
- Highly Cited
A Phase 3 Trial of l-Glutamine in Sickle Cell Disease.
- 2018-07-19
- RCT · n = 230
- The New England journal of medicine 379(3)
- - Yutaka Niihara
  - Scott T Miller
  - Julie Kanter
  - Sophie Lanzkron
  - Wally R Smith
  - Lewis L Hsu
  - Victor R Gordeuk
  - Kusum Viswanathan
  - Sharada Sarnaik
  - Ifeyinwa Osunkwo
  - Edouard Guillaume
  - Swayam Sadanandan
  - Lance Sieger
  - Joseph L Lasky
  - Eduard H Panosyan
  - Osbourne A Blake
  - Tamara N New
  - Rita Bellevue
  - Lan T Tran
  - Rafael L Razon
  - Charles W Stark
  - Lynne D Neumayr
  - Elliott P Vichinsky
- PubMed: 30021096
- DOI: 10.1056/nejmoa1715971
2 Insights on
- Reduced Hospitalization
- Reduced Pain Crises
- High evidence
- Large Human Trial
- Highly Cited
Lactobacillus rhamnosus Probiotic Food as a Tool for Empowerment Across the Value Chain in Africa
- 2018-07-10
- Frontiers in Microbiology 9
- - Nieke Westerik
  - R. Kort
  - W. Sybesma
  - G. Reid
- PubMed: 30042747
- DOI: 10.3389/fmicb.2018.01501
1 Insight on
- Improved Nutritional Status
- Low evidence
The Gut Microbiome as a Major Regulator of the Gut-Skin Axis.
- 2018-07-10
- Review
- Frontiers in microbiology 9
- - Iman Salem
  - Amy Ramser
  - Nancy Isham
  - Mahmoud A Ghannoum
- PubMed: 30042740
- DOI: 10.3389/fmicb.2018.01459
2 Insights on
- Improved Skin Hydration
- Improved Skin Barrier Function
- Moderate evidence
- Highly Cited
Antihypertensive peptides from whey proteins fermented by lactic acid bacteria.
- 2018-07-06
- Food science and biotechnology 27(6)
- - Eric Banan-Mwine Daliri
  - Byong H Lee
  - Byun-Jae Park
  - Se-Hun Kim
  - Deog-Hwan Oh
- PubMed: 30483443
- DOI: 10.1007/s10068-018-0423-0
3 Insights on
- Low evidence
Bacillus coagulans MTCC 5856 for the management of major depression with irritable bowel syndrome: a randomised, double-blind, placebo controlled, multi-centre, pilot clinical study
- 2018-07-04
- RCT · n = 40
- Food & Nutrition Research 62(0)
- - M. Majeed
  - K. Nagabhushanam
  - S. Arumugam
  - Shaheen Majeed
  - Furqan Ali
- PubMed: 29997457
- DOI: 10.29219/fnr.v62.1218
9 Insights on
- High evidence
- Highly Cited
- Rigorous Journal
A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the human circadian clock.
- 2018-07-03
- RCT
- Chronobiology international 35(10)
- - Takafumi Fukuda
  - Atsushi Haraguchi
  - Masaki Takahashi
  - Takashi Nakaoka
  - Mayuko Fukazawa
  - Jin Okubo
  - Mamiho Ozaki
  - Ayana Kanatome
  - Rena Ohya
  - Yutaka Miura
  - Kuniaki Obara
  - Shigenobu Shibata
- PubMed: 29969301
- DOI: 10.1080/07420528.2018.1490315
1 Insight on
- Delayed Dim Light Melatonin Onset
- High evidence
Fermented camel milk by Lactococcus lactis subsp. cremoris attenuates erythrocytes oxidative stress-induced hematological and immunological damage in CCl4-intoxicated mice
- 2018-07-02
- RCT · n = 28
- Environmental Science and Pollution Research 25(26)
- - H. Hamed
  - Fatma Châari
  - Zied Ghannoudi
  - Kaouther Dhouib
  - S. Châabouni
  - A. Feki
  - A. Gargouri
- PubMed: 29968212
- DOI: 10.1007/s11356-018-2623-9
4 Insights on
- Low evidence
- Animal Study
Lactobacillus fermentum Improves Tacrolimus‐Induced Hypertension by Restoring Vascular Redox State and Improving eNOS Coupling
- 2018-06-28
- Clinical Trial
- Molecular Nutrition & Food Research 62(14)
- - M. Toral
  - M. Romero
  - A. Rodríguez‐Nogales
  - R. Jiménez
  - Iñaki Robles‐Vera
  - F. Algieri
  - N. Chueca-Porcuna
  - M. Sánchez
  - Néstor de la Visitación
  - M. Olivares
  - Federico García
  - F. Pérez-Vizcaino
  - J. Gálvez
  - J. Duarte
- PubMed: 29851248
- DOI: 10.1002/mnfr.201800033
6 Insights on
- Low evidence
- Highly Cited
- Rigorous Journal
- Animal Study