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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Efficacy of ginkgo biloba extract in the treatment of idiopathic pulmonary fibrosis: a systematic review and meta-analysis of randomized controlled trials.
- 2025-03-05
- Review · n = 1,043
- Frontiers in pharmacology 16
- - Xuxin Sun
  - Ling Peng
  - Wenchao Xiao
  - Keying Li
  - Sheng Chen
- PubMed: 40110130
- DOI: 10.3389/fphar.2025.1524505
11 Insights on
- High evidence
Effect of Daily Avocado Intake on Cardiovascular Health Assessed by Life's Essential 8: An Ancillary Study of HAT, a Randomized Controlled Trial.
- 2025-03-04
- RCT · n = 969
- Journal of the American Heart Association 14(5)
- - Janhavi J Damani
  - Penny M Kris-Etherton
  - Alice H Lichtenstein
  - Nirupa R Matthan
  - Joan Sabaté
  - Zhaoping Li
  - David Reboussin
  - Kristina S Petersen
- PubMed: 39968784
- DOI: 10.1161/jaha.124.039130
4 Insights on
- High evidence
- Large Human Trial
The Impact of Testosterone Therapy on the Vaginal Microbiota of Transgender Men and Nonbinary People: A Prospective Study.
- 2025-03-03
- Observational
- The Journal of infectious diseases 232(3)
- - Olivia T Van Gerwen
  - Kristal J Aaron
  - Emma Sophia Kay
  - Krishmita Siwakoti
  - Angela Pontius
  - Saralyn Richter
  - Z Alex Sherman
  - Keonte J Graves
  - Ashutosh Tamhane
  - Jacob H Elnaggar
  - Meng Luo
  - Evelyn Toh
  - David E Nelson
  - Nicholas J Van Wagoner
  - Christopher M Taylor
  - Christina A Muzny
- PubMed: 40037329
- DOI: 10.1093/infdis/jiaf114
1 Insight on
- No Human Health Outcome Reported
- Low evidence
Lactobacillus plantae Expressing Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Single-Chain Antibody Can Inhibit PRRSV Replication and Change the Intestinal Flora Structure of Piglets.
- 2025-03-03
- International journal of molecular sciences 26(5)
- - Tianming Niu
  - Tianqi Fan
  - Yingjie Wang
  - Kuipeng Gao
  - Jinhui Zhao
  - Ruyu Wang
  - Xiaolei Chen
  - Junhong Xing
  - Jingjing Qiu
  - Boshi Zou
  - Shuhui Fan
  - Shi Zhang
  - Qiong Wu
  - Guilian Yang
  - Nan Wang
  - Yan Zeng
  - Xin Cao
  - Yanlong Jiang
  - Jianzhong Wang
  - Haibin Huang
  - Wentao Yang
  - Chunwei Shi
  - Zhipeng Li
  - Chunfeng Wang
- PubMed: 40076879
- DOI: 10.3390/ijms26052257
6 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Therapeutic Value of Lactobacillus gasseri 345A in Chronic Constipation.
- 2025-03-03
- RCT · n = 40
- Neurogastroenterology and motility 37(5)
- - Stefan Roos
  - Atti-La Dahlgren
  - Yu-Kang Mao
  - Anton Pallin
  - Andrew M Stanisz
  - Paul Forsythe
  - Wolfgang Kunze
  - Per M Hellström
- PubMed: 40033155
- DOI: 10.1111/nmo.70012
9 Insights on
- High evidence
Lactobacillus reuteri protectis DSM 17938 at high doses versus placebo in children with acute gastroenteritis in a Pediatric Emergency Department.
- 2025-03-03
- RCT
- Journal of pediatric gastroenterology and nutrition 80(5)
- - Ricardo Iramain
  - Alfredo Jara
  - Jorge Ortiz
  - Laura Cardozo
  - Rocío Morinigo
- PubMed: 40026275
- DOI: 10.1002/jpn3.70026
1 Insight on
- Reduced Diarrhea Rate
- High evidence
Where Biology Meets Engineering: Scaling Up Microbial Nutraceuticals to Bridge Nutrition, Therapeutics, and Global Impact.
- 2025-03-02
- Review
- Microorganisms 13(3)
- - Ahmed M Elazzazy
  - Mohammed N Baeshen
  - Khalid M Alasmi
  - Shatha I Alqurashi
  - Said E Desouky
  - Sadat M R Khattab
- PubMed: 40142459
- DOI: 10.3390/microorganisms13030566
1 Insight on
- Improved Intestinal Function
- Low evidence
Malate or Not? Acute Effects of L-Citrulline Versus Citrulline Malate on Neuromuscular Performance in Young, Trained Adults: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial.
- 2025-03-01
- RCT · n = 21
- International journal of sport nutrition and exercise metabolism 35(2)
- - Juan J Martín-Olmedo
  - Sergio Miras-Moreno
  - Kevin Cuadra-Montes
  - Amador García-Ramos
  - Jonatan R Ruiz
  - Lucas Jurado-Fasoli
- PubMed: 39662304
- DOI: 10.1123/ijsnem.2024-0006
9 Insights on
- High evidence
Post-Exercise Hypotension after Exercising in Hypoxia with and Without Tart Cherry Supplementation.
- 2025-03-01
- RCT
- High altitude medicine & biology 26(1)
- - Masahiro Horiuchi
  - Samuel J Oliver
- PubMed: 39545270
- DOI: 10.1089/ham.2024.0076
2 Insights on
- Reduced Mean Arterial Pressure
- Improved Cardiac Baroreflex Sensitivity
- High evidence
Exploring the Effects of a Calming Herbal Tea Blend on Perioperative Anxiety: A Randomized Clinical Trial.
- 2025-03-01
- RCT · n = 210
- Journal of medicinal food 28(3)
- - Victória Cosel Zampieri
  - Itamar Luís Gonçalves
  - Ana Luiza Lira
  - Jamile Zeni
  - Geciane Toniazzo Backes
  - André Keng Wei Hsu
- PubMed: 39514279
- DOI: 10.1089/jmf.2024.0170
1 Insight on
- Reduced Anxiety
- High evidence
- Large Human Trial
Rehydration Beverages Made from Quercus sideroxyla Infusion, Probiotics, and Prebiotics: Antioxidant and Anti-Inflammatory Potential.
- 2025-02-28
- Foods (Basel, Switzerland) 14(5)
- - Carlos Alonso Salas-Ramírez
  - Martha Rocío Moreno-Jiménez
  - Nuria Elizabeth Rocha-Guzmán
  - José Alberto Gallegos-Infante
  - Rubén Francisco González-Laredo
  - Silvia Marina González Herrera
  - Manuel Efraín González-Mercado
  - Karen Marlenne Herrera-Rocha
  - Manuel Humberto Cháirez-Ramirez
- PubMed: 40077540
- DOI: 10.3390/foods14050837
1 Insight on
- Reduced Inflammation
- Low evidence
Clinical Evaluation of Ganoderma lucidum Spore Oil for Triglyceride Reduction: A Randomized, Double-Blind, Crossover Study.
- 2025-02-28
- RCT · n = 110
- Nutrients 17(5)
- - Xinyi Wang
  - Xufeng Wang
  - Liang Zhao
  - Feng Zhou
- PubMed: 40077714
- DOI: 10.3390/nu17050844
6 Insights on
- High evidence
- Large Human Trial
- Rigorous Journal
Streptococcus salivarius and Ligilactobacillus salivarius: Paragons of Probiotic Potential and Reservoirs of Novel Antimicrobials.
- 2025-02-28
- Review
- Microorganisms 13(3)
- - McKinley D Williams
  - Leif Smith
- PubMed: 40142448
- DOI: 10.3390/microorganisms13030555
6 Insights on
- Low evidence
Daily Vitamin D3 Versus Stoss Vitamin D3 for Correction of 25OHD Deficiency in Children with Inflammatory Bowel Disease, a Randomised Controlled Trial.
- 2025-02-28
- RCT · n = 74
- Digestive diseases and sciences 70(5)
- - Jonathan E M O'Donnell
  - Steven T Leach
  - Nerissa L Bowcock
  - Siying Chen
  - Nitin Gupta
  - Kevin Jiang
  - Robert N Lopez
  - Rachel Messenger
  - Lily Nahidi
  - Amanda Shapiro
  - Andrew S Day
  - Daniel A Lemberg
- PubMed: 40021606
- DOI: 10.1007/s10620-025-08913-3
12 Insights on
- High evidence
- Rigorous Journal
Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis.
- 2025-02-27
- Meta-Analysis · n = 1,049
- Neuropsychopharmacology reports 45(1)
- - Minoru Urata
  - Hitoshi Sakurai
  - Fumihiko Ueno
  - Taku Maruki
  - Teruo Tada
  - Takahito Uchida
  - Yasuyuki Matsumoto
  - Masami Murao
  - Masayuki Tomita
  - Hajime Baba
  - Masaki Kato
  - Takashi Tsuboi
  - Koichiro Watanabe
- PubMed: 40014460
- DOI: 10.1002/npr2.70008
1 Insight on
- Improved Depressive Symptoms
- High evidence
Targeting gut microbiota as a therapeutic approach for neurodegenerative diseases.
- 2025-02-27
- Review
- Neuroprotection (Chichester, England) 3(2)
- - Tobiloba S Olajide
  - Omamuyovwi M Ijomone
- PubMed: 40589476
- DOI: 10.1002/nep3.70000
3 Insights on
- Low evidence
Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
- 2025-02-27
- RCT · n = 165
- Nutrients 17(5)
- - Femke de Vries
  - Rudolf Bittner
  - Katarzyna Maresz
  - François Machuron
  - Olav Gåserød
  - Jean-François Jeanne
  - Leon J Schurgers
- PubMed: 40077685
- DOI: 10.3390/nu17050815
3 Insights on
- High evidence
- Large Human Trial
- Rigorous Journal
The Therapeutic Effects of Curcumin on Oral Disease: A Systematic Review.
- 2025-02-27
- Review · n = 1,244
- Clinical pharmacology : advances and applications 17
- - Novi Indriyani
  - Nanan Nur'aeny
- PubMed: 40034679
- DOI: 10.2147/cpaa.s506396
3 Insights on
- High evidence
Clinical significance of perioperative probiotic intervention on recovery following intestinal surgery.
- 2025-02-27
- RCT · n = 60
- World journal of gastrointestinal surgery 17(2)
- - Yang Wu
  - Xin Zhang
  - Guan-Qiao Wang
  - Yan Jiao
- PubMed: 40062001
- DOI: 10.4240/wjgs.v17.i2.97503
1 Insight on
- Improved Gastrointestinal Recovery
- High evidence
The Significance of Probiotics in Aquaculture: A Review of Research Trend and Latest Scientific Findings.
- 2025-02-27
- Review
- Antibiotics (Basel, Switzerland) 14(3)
- - Elshafia Ali Hamid Mohammed
  - Abdelhakam Esmaeil Mohamed Ahmed
  - Béla Kovács
  - Károly Pál
- PubMed: 40149052
- DOI: 10.3390/antibiotics14030242
1 Insight on
- No Human Health Outcome Reported
- Low evidence
Acute effects of Hibiscus sabdariffa on blood pressure and cognitive function.
- 2025-02-26
- RCT
- Nutritional neuroscience 28(9)
- - Lucy Ellis
  - Stephania Aragón-Rojas
  - Louise Dye
  - Christine Boesch
- PubMed: 40009760
- DOI: 10.1080/1028415x.2025.2462944
6 Insights on
- High evidence
In vitro modulation of proinflammatory and proteolytic activities of Porphyromonas gingivalis by selected lactobacilli.
- 2025-02-25
- Journal of oral microbiology 17(1)
- - Johana R Naja
  - Leyla Desparois
  - Elvira M Hebert
  - Maria Elena Fátima Nader
  - Lucila Saavedra
  - Carlos J Minahk
  - Vanessa P Houde
- PubMed: 40013015
- DOI: 10.1080/20002297.2025.2469894
1 Insight on
- Reduced Inflammatory Response
- Low evidence
The efficacy and safety of berberine in combination with cinnamon supplementation in patients with type 2 diabetes: a randomized clinical trial.
- 2025-02-25
- RCT
- European journal of nutrition 64(2)
- - Asieh Mansour
  - Sayed Mahmoud Sajjadi-Jazi
  - Hadis Gerami
  - Atie Sadat Khorasanian
  - Behnam Moalemzadeh
  - Sara Karimi
  - Nima Mohamadi Afrakoti
  - Vahid Mofid
  - Mohammad Reza Mohajeri-Tehrani
  - Azita Hekmatdoost
- PubMed: 39998703
- DOI: 10.1007/s00394-025-03618-9
10 Insights on
- High evidence
- Rigorous Journal
Peanut Oral Immunotherapy in Children with High-Threshold Peanut Allergy.
- 2025-02-25
- RCT · n = 73
- NEJM evidence 4(3)
- - Scott H Sicherer
  - Supinda Bunyavanich
  - M Cecilia Berin
  - Tracy Lo
  - Marion Groetch
  - Allison Schaible
  - Susan A Perry
  - Lisa M Wheatley
  - Patricia C Fulkerson
  - Helena L Chang
  - Mayte Suárez-Fariñas
  - Hugh A Sampson
  - Julie Wang
- PubMed: 39928078
- DOI: 10.1056/evidoa2400306
2 Insights on
- Improved Peanut Tolerance
- Achieved Sustained Unresponsiveness
- High evidence
Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: A randomized controlled trial.
- 2025-02-25
- RCT
- Nutrition, metabolism, and cardiovascular diseases : NMCD 35(8)
- - Bangwei Chen
  - Yaxin Li
  - Zhiming Li
  - Xiaojie Hu
  - Hefu Zhen
  - Hongyun Chen
  - Chao Nie
  - Yong Hou
  - Shida Zhu
  - Liang Xiao
  - Tao Li
- PubMed: 40087044
- DOI: 10.1016/j.numecd.2025.103964
1 Insight on
- Reduced Low-Density Lipoprotein Level
- High evidence
Can We Modulate Our Second Brain and Its Metabolites to Change Our Mood? A Systematic Review on Efficacy, Mechanisms, and Future Directions of "Psychobiotics".
- 2025-02-25
- Systematic Review
- International journal of molecular sciences 26(5)
- - Stefania Garzone
  - Ioannis Alexandros Charitos
  - Manuela Mandorino
  - Maria Elena Maggiore
  - Loredana Capozzi
  - Bujar Cakani
  - Gabriel César Dias Lopes
  - Luisella Bocchio-Chiavetto
  - Marica Colella
- PubMed: 40076598
- DOI: 10.3390/ijms26051972
3 Insights on
- High evidence
- Rigorous Journal
Hericium erinaceus: A possible future therapeutic treatment for the prevention and delayed progression of Alzheimer's disease? - A narrative review.
- 2025-02-24
- Review
- Nutrition research reviews 38(2)
- - Nisha Cornford
  - Margaret Charnley
- PubMed: 39988819
- DOI: 10.1017/s0954422425000058
1 Insight on
- Improved Cognitive Function
- Low evidence
Inter-individual differences in the blood pressure lowering effects of dietary nitrate: a randomised double-blind placebo-controlled replicate crossover trial.
- 2025-02-24
- RCT
- European journal of nutrition 64(2)
- - Eleanor Hayes
  - Shatha Alhulaefi
  - Mario Siervo
  - Eleanor Whyte
  - Rachel Kimble
  - Jamie Matu
  - Alex Griffiths
  - Marc Sim
  - Mia Burleigh
  - Chris Easton
  - Lorenzo Lolli
  - Greg Atkinson
  - John C Mathers
  - Oliver M Shannon
- PubMed: 39992469
- DOI: 10.1007/s00394-025-03616-x
2 Insights on
- Reduced Diastolic Blood Pressure
- Reduced Systolic Blood Pressure
- High evidence
- Rigorous Journal
Does supplementation with pine bark extract improve cardiometabolic risk factors? A systematic review and meta-analysis.
- 2025-02-22
- Meta-Analysis · n = 685
- BMC complementary medicine and therapies 25(1)
- - Shooka Mohammadi
  - Tamas Fulop
  - Abdelouahed Khalil
  - Sara Ebrahimi
  - Motahareh Hasani
  - Somayeh Ziaei
  - Farnaz Farsi
  - Elham Mirtaheri
  - Mostafa Afsharianfar
  - Javad Heshmati
- PubMed: 39987124
- DOI: 10.1186/s12906-025-04819-9
3 Insights on
- High evidence
Effectiveness of Herbal Medicines with Anti-Inflammatory, Antimicrobial, and Antioxidant Properties in Improving Oral Health and Treating Gingivitis and Periodontitis: A Systematic Review.
- 2025-02-21
- Systematic Review
- Nutrients 17(5)
- - Giuseppina Malcangi
  - Angelo Michele Inchingolo
  - Lucia Casamassima
  - Irma Trilli
  - Laura Ferrante
  - Francesco Inchingolo
  - Andrea Palermo
  - Alessio Danilo Inchingolo
  - Gianna Dipalma
- PubMed: 40077632
- DOI: 10.3390/nu17050762
3 Insights on
- High evidence
- Rigorous Journal