June 2018 Supplement Research Papers

• June 1

  • Effects of Dietary Clostridium butyricum on the Growth, Digestive Enzyme Activity, Antioxidant Capacity, and Resistance to Nitrite Stress of Penaeus monodon

    • 2018-06-01
    • RCT
    • Probiotics and Antimicrobial Proteins 11(3)
    • • Yafei Duan
      • Jiasong Zhang
      • Jianhua Huang
      • Shi-gui Jiang

    • PubMed: 29858778
    • DOI: 10.1007/s12602-018-9421-z

    4 Insights on

    • Improved Growth Rate
    • Improved Antioxidant Capacity
    • Improved Survival Rate Under Nitrite Stress
    • Improved Intestinal Digestive Enzyme Activity

    • Low evidence
    • Animal Study

  • Intake of Bifidobacterium longum and Fructo-oligosaccharides prevents Colorectal Carcinogenesis

    • 2018-06-01
    • Clinical Trial · n = 27
    • Euroasian Journal of Hepato-Gastroenterology 8(1)
    • • T. Ohara
      • T. Suzutani

    • PubMed: 29963455
    • DOI: 10.5005/jp-journals-10018-1251

    4 Insights on

    • Increased Short Chain Fatty Acids
    • Reduced Enterotoxigenic Bacteroides fragilis (ETBF) Levels
    • Reduced Growth of Putrefactive Bacteria
    • Reduced Short-Chain Fatty Acids (SCFA)

    • Moderate evidence
• June 6

  • The anti-apoptotic and anti-inflammatory effect of Lactobacillus acidophilus on Shigella sonnei and Vibrio cholerae interaction with intestinal epithelial cells: A comparison between invasive and non-invasive bacteria

    • 2018-06-06
    • PLOS ONE 13(6)
    • • Shabnam Zeighamy Alamdary
      • B. Bakhshi
      • S. Soudi

    • PubMed: 29874233
    • DOI: 10.1371/journal.pone.0196941

    3 Insights on

    • Reduced Inflammatory Response
    • No Apoptosis in Host Cells
    • Increased Anti-Apoptotic Response Against Bacterial Infection

    • Low evidence
    • Rigorous Journal
• June 11

  • Preventive Effect of a Synbiotic Combination of Galacto- and Fructooligosaccharides Mixture With Bifidobacterium breve M-16V in a Model of Multiple Rotavirus Infections

    • 2018-06-11
    • Clinical Trial
    • Frontiers in Immunology 9
    • • M. Rigo-Adrover
      • K. van Limpt
      • K. Knipping
      • J. Garssen
      • J. Knol
      • A. Costabile
      • À. Franch
      • M. Castell
      • F. Pérez-Cano

    • PubMed: 29942312
    • DOI: 10.3389/fimmu.2018.01318

    4 Insights on

    • Reduced Diarrhea Symptoms
    • Modulated Immune Response
    • Reduced Rotavirus Shedding
    • Enhanced Early Immune Response

    • Low evidence
    • Animal Study
• June 12

  • Effects of the Dietary Probiotic, Enterococcus faecium NCIMB11181, on the Intestinal Barrier and System Immune Status in Escherichia coli O78-Challenged Broiler Chickens

    • 2018-06-12
    • RCT · n = 388
    • Probiotics and Antimicrobial Proteins 11(3)
    • • Liqing Huang
      • L. Luo
      • Yaru Zhang
      • Zhong Wang
      • Z. Xia

    • PubMed: 29948799
    • DOI: 10.1007/s12602-018-9434-7

    5 Insights on

    • Increased Body Weight
    • Improved Average Daily Gain
    • Reduced E. coli Levels
    • Reduced Mortality Rate
    • Enhanced Immune Response Regulation

    • Low evidence
    • Animal Study
• June 13

  • Potential Use of Bacillus coagulans in the Food Industry

    • 2018-06-13
    • Review
    • Foods 7(6)
    • • Gözde Konuray
      • Z. Erginkaya

    • PubMed: 29899254
    • DOI: 10.3390/foods7060092

    2 Insights on

    • Increased Thermal Resilience
    • Increased Probiotic Activity

    • Moderate evidence
    • Highly Cited

  • Orally administered heat-killed Lactobacillus paracasei MCC1849 enhances antigen-specific IgA secretion and induces follicular helper T cells in mice

    • 2018-06-13
    • Clinical Trial
    • PLOS ONE 13(6)
    • • S. Arai
      • N. Iwabuchi
      • Sachiko Takahashi
      • J. Xiao
      • F. Abe
      • S. Hachimura

    • PubMed: 29897995
    • DOI: 10.1371/journal.pone.0199018

    3 Insights on

    • Improved Antigen-Specific IgA Secretion
    • Increased IgA Production
    • Increased Follicular Helper T Cell Activity

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Long-Term Diet Supplementation with Lactobacillus paracasei K71 Prevents Age-Related Cognitive Decline in Senescence-Accelerated Mouse Prone 8

    • 2018-06-13
    • Clinical Trial
    • Nutrients 10(6)
    • • H. M. Corpuz
      • Saki Ichikawa
      • Misa Arimura
      • Toshihiro Mihara
      • T. Kumagai
      • Takakazu Mitani
      • Soichiro Nakamura
      • S. Katayama

    • PubMed: 29899283
    • DOI: 10.3390/nu10060762

    3 Insights on

    • Increased Serotonin Levels
    • Enhanced Brain-Derived Neurotrophic Factor Levels
    • Improved Cognitive Performance

    • Low evidence
    • Animal Study
• June 15

  • Efficacy of Bacillus coagulans Unique IS2 in treatment of irritable bowel syndrome in children: a double blind, randomised placebo controlled study.

    • 2018-06-15
    • RCT · n = 141
    • Beneficial Microbes 9(4)
    • • M. Sudha
      • N. Jayanthi
      • M. Aasin
      • R.D. Dhanashri
      • T. Anirudh

    • PubMed: 29695183
    • DOI: 10.3920/BM2017.0129

    11 Insights on

    • Reduced Straining
    • Improved Stool Consistency
    • Reduced Bloating
    • Reduced Abdominal Discomfort
    • Reduced Pain Intensity
    • Reduced Pain Intensity in Irritable Bowel Syndrome
    • Reduced Urgency of Bowel Movements
    • Reduced Sense of Incomplete Evacuation
    • Reduced Passage of Gas
    • Improved Bowel Habit Satisfaction
    • Global Relief Assessment

    • High evidence

  • Comparative Genomic and Phenotypic Analysis of the Vaginal Probiotic Lactobacillus rhamnosus GR-1

    • 2018-06-15
    • Frontiers in Microbiology 9
    • • M. Petrova
      • Jean M. Macklaim
      • S. Wuyts
      • T. Verhoeven
      • J. Vanderleyden
      • G. Gloor
      • S. Lebeer
      • G. Reid

    • PubMed: 29963028
    • DOI: 10.3389/fmicb.2018.01278

    1 Insight on

    • Improved Oxidative Stress Resistance

    • Low evidence

  • Anti-obesity properties of the strain Bifidobacterium animalis subsp. lactis CECT 8145 in Zücker fatty rats.

    • 2018-06-15
    • RCT · n = 20
    • Beneficial Microbes 9(4)
    • • N. L. Carreras
      • P. Martorell
      • E. Chenoll
      • S. Genovés
      • Daniel Ramón
      • A. Aleixandre

    • PubMed: 29695181
    • DOI: 10.3920/BM2017.0141

    19 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Body Weight
    • Reduced Hepatic Oxidative Stress
    • Reduced Inflammatory Markers
    • Increased Adiponectin Levels
    • Reduced Food Intake
    • Reduced TNF-α Levels
    • Reduced Serum Malondialdehyde Levels
    • Reduced Weight Gain
    • Reduced Plasma Ghrelin Levels
    • Improved Cholesterol Profile
    • Reduced Plasma Malondialdehyde Levels
    • Reduced Total Cholesterol to HDL Cholesterol Ratio
    • Reduced Cardiovascular Dysfunction
    • Improved Cardiovascular Health
    • No Change in Serum Triglycerides
    • Reduced Plasma Tumor Necrosis Factor-α Levels
    • Reduced Incidence of Cardiovascular Disease
    • No Significant Effect on Glucose Metabolism

    • Low evidence
    • Animal Study

  • A synbiotic mixture of scGOS/lcFOS and Bifidobacterium breve M-16V increases faecal Bifidobacterium in healthy young children.

    • 2018-06-15
    • RCT · n = 129
    • Beneficial Microbes 9(4)
    • • P. Kosuwon
      • M. Lao-Araya
      • S. Uthaisangsook
      • C. Lay
      • J. Bindels
      • J. Knol
      • P. Chatchatee

    • PubMed: 29633642
    • DOI: 10.3920/BM2017.0110

    3 Insights on

    • Improved Stool Consistency
    • Increased Bifidobacteria Levels
    • Reduced Lower Intestinal pH

    • High evidence

  • Effects of heat-treated Lactobacillus crispatus KT-11 strain consumption on improvement of oral cavity environment: a randomised double-blind clinical trial.

    • 2018-06-15
    • RCT · n = 16
    • Beneficial Microbes 9(4)
    • • K. Tobita
      • I. Watanabe
      • M. Tomokiyo
      • M. Saito

    • PubMed: 29633644
    • DOI: 10.3920/BM2017.0137

    3 Insights on

    • Reduced P. gingivalis Numbers
    • Improved Gum Health
    • Increased Oral Mucosa Fluid Levels in Male Participants

    • High evidence

  • Beta-alanine supplementation improves isometric, but not isotonic or isokinetic strength endurance in recreationally strength-trained young men.

    • 2018-06-15
    • RCT · n = 11
    • Amino acids 51(1)
    • • Diogo Bassinello
      • Vitor de Salles Painelli
      • Eimear Dolan
      • Manoel Lixandrão
      • Monique Cajueiro
      • Mariana de Capitani
      • Bryan Saunders
      • Craig Sale
      • Guilherme G Artioli
      • Bruno Gualano
      • Hamilton Roschel

    • PubMed: 29905904
    • DOI: 10.1007/s00726-018-2593-8

    3 Insights on

    • Improved Isometric Strength Endurance
    • Improved Isokinetic Strength Endurance
    • Improved Isotonic Strength Endurance

    • High evidence
• June 22

  • Supplementation of Lactobacillus plantarum Improves Markers of Metabolic Dysfunction Induced by a High Fat Diet.

    • 2018-06-22
    • Clinical Trial · n = 10
    • Journal of Proteome Research 17(8)
    • • A. Martinic
      • J. Barouei
      • Zachary A. Bendiks
      • Darya O Mishchuk
      • Dustin D Heeney
      • Roy J Martin
      • M. Marco
      • C. Slupsky

    • PubMed: 29931981
    • DOI: 10.1021/acs.jproteome.8b00282

    5 Insights on

    • Increased Gut Lactobacillus plantarum Population
    • Improved Glucose Regulation
    • Improved Systemic Metabolism
    • Increased Lactobacillus plantarum Levels
    • Improved Glucose Homeostasis

    • Low evidence
    • Animal Study
• June 28

  • Probiotic Bifidobacterium strains and galactooligosaccharides improve intestinal barrier function in obese adults but show no synergism when used together as synbiotics

    • 2018-06-28
    • RCT
    • Microbiome 6(1)
    • • Janina A. Krumbeck
      • H. Rasmussen
      • R. Hutkins
      • Jennifer L Clarke
      • Krista M Shawron
      • A. Keshavarzian
      • J. Walter

    • PubMed: 29954454
    • DOI: 10.1186/s40168-018-0494-4

    3 Insights on

    • Increased Bifidobacteria Levels
    • Reduced Colonic Permeability
    • Improved Intestinal Epithelial Permeability

    • High evidence
    • Highly Cited

  • Lactobacillus fermentum Improves Tacrolimus‐Induced Hypertension by Restoring Vascular Redox State and Improving eNOS Coupling

    • 2018-06-28
    • Clinical Trial
    • Molecular Nutrition & Food Research 62(14)
    • • M. Toral
      • M. Romero
      • A. Rodríguez‐Nogales
      • R. Jiménez
      • Iñaki Robles‐Vera
      • F. Algieri
      • N. Chueca-Porcuna
      • M. Sánchez
      • Néstor de la Visitación
      • M. Olivares
      • Federico García
      • F. Pérez-Vizcaino
      • J. Gálvez
      • J. Duarte

    • PubMed: 29851248
    • DOI: 10.1002/mnfr.201800033

    6 Insights on

    • Reduced Hypertension
    • Improved Gut Microbiome Composition
    • Reduced Inflammation
    • Reduced Oxidative Stress
    • Improved Microbial Diversity
    • Improved Vascular Endothelial Function

    • Low evidence
    • Highly Cited
    • Rigorous Journal
    • Animal Study
• Undated – 5 supplement studies

  • Effects of Pediococcus acidilactici, mannan‐oligosaccharide, butyric acid and their combination on growth performance and intestinal health in young broiler chickens challenged with Salmonella Typhimurium

    • 2018-06
    • RCT · n = 420
    • Poultry Science 97(6)
    • • V. Jazi
      • A. Foroozandeh
      • M. Toghyani
      • B. Dastar
      • R. R. Koochaksaraie

    • PubMed: 29514269
    • DOI: 10.3382/ps/pey035

    11 Insights on

    • Improved Gastrointestinal Health
    • Improved Immune Response
    • Reduced Inflammatory Response
    • Improved Intestinal Function
    • Improved Growth Performance
    • Reduced Salmonella Population
    • Improved Enzyme Activity
    • Reduced Stress Indicators
    • Normalized Stress Response
    • Reduced Heterophil-to-Lymphocyte Ratio
    • Restored Digestive Enzyme Activity

    • Low evidence
    • Highly Cited
    • Rigorous Journal
    • Animal Study

  • Lactobacillus plantarum YS-3 Prevents Activated Carbon-Induced Constipation in Mice.

    • 2018-06
    • Clinical Trial
    • Journal of Medicinal Food 21(6)
    • • Xin Zhao
      • Ruokun Yi
      • Y. Qian
      • Kun-Young Park

    • PubMed: 29757072
    • DOI: 10.1089/jmf.2017.4109

    4 Insights on

    • Improved Gastrointestinal Transit
    • Increased Intestinal GLP-1 Levels
    • Reduced Intestinal Damage
    • Enhanced Bile Salt Resistance

    • Low evidence
    • Animal Study

  • Bifidobacterium bifidum YIT 10347 fermented milk exerts beneficial effects on gastrointestinal discomfort and symptoms in healthy adults: A double-blind, randomized, placebo-controlled study.

    • 2018-06
    • RCT · n = 100
    • Journal of Dairy Science 101(6)
    • • A. Gomi
      • K. Yamaji
      • O. Watanabe
      • M. Yoshioka
      • K. Miyazaki
      • Y. Iwama
      • Y. Urita

    • PubMed: 29573807
    • DOI: 10.3168/jds.2017-13803

    12 Insights on

    • Reduced Diarrhea Incidence
    • Reduced Gastrointestinal Symptoms
    • Reduced Flatulence
    • Reduced Diarrhea Rate
    • Improved Gastrointestinal Symptoms
    • Reduced Postprandial Discomfort
    • Reduced Epigastric Pain
    • Relieved Gastrointestinal Symptoms
    • Reduced Diarrhea
    • Relieved Postprandial Discomfort
    • Improved Overall Gastrointestinal Symptoms
    • Improved Gastrointestinal Symptom Relief

    • High evidence
    • Rigorous Journal

  • l-Carnosine as Adjunctive Therapy in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

    • 2018-06
    • RCT
    • Journal of child and adolescent psychopharmacology 28(5)
    • • Alireza Ghajar
      • Farinaz Aghajan-Nashtaei
      • Mohsen Afarideh
      • Mohammad-Reza Mohammadi
      • Shahin Akhondzadeh

    • PubMed: 29469593
    • DOI: 10.1089/cap.2017.0157

    6 Insights on

    • Improved Attention Span
    • Reduced Hyperactivity
    • Reduced ADHD Symptoms
    • Reduced Inattention Symptoms
    • Reduced ADHD Symptom
    • Reduced Hyperactivity Symptoms

    • High evidence

  • Effect of Irvingia gabonensis on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion.

    • 2018-06
    • RCT · n = 24
    • Journal of medicinal food 21(6)
    • • Miriam Méndez-Del Villar
      • Manuel González-Ortiz
      • Esperanza Martínez-Abundis
      • Karina G Pérez-Rubio
      • Marisol Cortez-Navarrete

    • PubMed: 29336718
    • DOI: 10.1089/jmf.2017.0092

    13 Insights on

    • Improved Insulin Sensitivity
    • Reduced Waist Circumference
    • Reduced Low-Density Lipoprotein Level
    • Reduced Triglyceride Levels
    • Increased Blood Glucose Levels
    • Improved Insulin Secretion
    • Reduced Glucose Level
    • Reduced Blood Glucose
    • Reduced Glucose Post-Challenge
    • Improved Metabolic Syndrome Remission
    • Reduced First Phase Insulin Secretion
    • Reduced Very Low-Density Lipoprotein Level
    • Remission of Metabolic Syndrome

    • High evidence