July 2020 Supplement Research Papers

• July 2

  • Bifidobacterium longum subsp. longum OLP-01 Supplementation during Endurance Running Training Improves Exercise Performance in Middle- and Long-Distance Runners: A Double-Blind Controlled Trial

    • 2020-07-02
    • RCT · n = 21
    • Nutrients 12(7)
    • • Che-Li Lin
      • Y. Hsu
      • H. Ho
      • Yung-Cheng Chang
      • Y. Kuo
      • Y. Yeh
      • S. Tsai
      • Ching-Wei Chen
      • J. Chen
      • Chi-Chang Huang
      • Mon-Chien Lee

    • PubMed: 32630786
    • DOI: 10.3390/nu12071972

    3 Insights on

    • Improved Exercise Performance
    • No Adverse Food Reactions
    • Unchanged Body Composition

    • High evidence
• July 3

  • A Double-Blind, Randomized, Placebo-Controlled Trial of Heat-Killed Pediococcus acidilactici K15 for Prevention of Respiratory Tract Infections among Preschool Children

    • 2020-07-03
    • RCT · n = 172
    • Nutrients 12(7)
    • • Haruka Hishiki
      • Tadaomi Kawashima
      • N. Tsuji
      • Naho Ikari
      • Ryo Takemura
      • H. Kido
      • N. Shimojo

    • PubMed: 32635408
    • DOI: 10.3390/nu12071989

    3 Insights on

    • Reduced Fever Duration
    • Maintained Secretory IgA Levels
    • Maintained Higher Salivary Immunoglobulin A Levels

    • High evidence
• July 11

  • Bacillus subtilis HU58 and Bacillus coagulans SC208 Probiotics Reduced the Effects of Antibiotic-Induced Gut Microbiome Dysbiosis in an M-SHIME® Model

    • 2020-07-11
    • Microorganisms 8(7)
    • • M. Marzorati
      • P. Abbeele
      • Sarah S Bubeck
      • Thomas Bayne
      • K. Krishnan
      • Aicacia Young
      • D. Mehta
      • A. DeSouza

    • PubMed: 32664604
    • DOI: 10.3390/microorganisms8071028

    7 Insights on

    • Reduced Interleukin-6 Levels
    • Improved Gut Microbiome
    • Reduced Gut Barrier Defect
    • Reduced TNF-α Levels
    • Reduced Inflammation
    • Improved Gut Barrier Function
    • Reduced Gut Membrane Barrier Damage

    • Low evidence
    • Rigorous Journal
• July 13

  • Bacteroides thetaiotaomicron and Lactobacillus johnsonii modulate intestinal inflammation and eliminate fungi via enzymatic hydrolysis of the fungal cell wall

    • 2020-07-13
    • Clinical Trial
    • Scientific Reports 10(1)
    • • Rogatien Charlet
      • Clovis Bortolus
      • B. Sendid
      • S. Jawhara

    • PubMed: 32661259
    • DOI: 10.1038/s41598-020-68214-9

    5 Insights on

    • Reduced Pathogen Growth
    • Reduced Pro-Inflammatory Mediator Production
    • Reduced Colitis Development
    • Reduced Inflammatory Parameters
    • Elimination of Candida glabrata

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Prebiotic Properties of Non-Fructosylated α-Galactooligosaccharides from PEA (Pisum sativum L.) Using Infant Fecal Slurries.

    • 2020-07-13
    • Foods (Basel, Switzerland) 9(7)
    • • María Del Carmen Marín-Manzano
      • Oswaldo Hernandez-Hernandez
      • Marina Diez-Municio
      • Cristina Delgado-Andrade
      • Francisco Javier Moreno
      • Alfonso Clemente

    • PubMed: 32668744
    • DOI: 10.3390/foods9070921

    1 Insight on

    • Improved Bifidogenic Response

    • Low evidence
• July 14

  • Cancer-protective effect of a synbiotic combination between Lactobacillus gasseri 505 and a Cudrania tricuspidata leaf extract on colitis-associated colorectal cancer

    • 2020-07-14
    • Clinical Trial
    • Gut Microbes 12(1)
    • • N. Oh
      • J. Y. Lee
      • You-Tae Kim
      • Saehun Kim
      • Ju-Hoon Lee

    • PubMed: 32663105
    • DOI: 10.1080/19490976.2020.1785803

    5 Insights on

    • Reduced Pro-Inflammatory Cytokines
    • Reduced Colon Tumor Incidence
    • Reduced Colonic Mucosa Damage
    • Increased Colon Barrier Biomarkers
    • Increased Pro-apoptotic Factor Levels

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Probiotic strains of Lactobacillus brevis and Lactobacillus plantarum as adjunct to non-surgical periodontal therapy: 3-month results of a randomized controlled clinical trial

    • 2020-07-14
    • RCT · n = 40
    • Clinical Oral Investigations 25(3)
    • • P. Pudgar
      • K. Povšič
      • K. Čuk
      • K. Seme
      • M. Petelin
      • R. Gašperšič

    • PubMed: 32666349
    • DOI: 10.1007/s00784-020-03449-4

    5 Insights on

    • Reduced Gingival Bleeding
    • Increase in Persistent Diseased Sites
    • Persistent Diseased Sites
    • Increased Number of Persistent Diseased Sites
    • Increased Number of Persisting Diseased Sites with Pocket Depth Greater than 4 mm

    • High evidence
• July 17

  • Assessment of Probiotic Properties of Lactobacillus salivarius Isolated From Chickens as Feed Additives

    • 2020-07-17
    • RCT
    • Frontiers in Veterinary Science 7
    • • Jian Wang
      • M. Ishfaq
      • Yuesheng Guo
      • Chunli Chen
      • Jichang Li

    • PubMed: 32766298
    • DOI: 10.3389/fvets.2020.00415

    12 Insights on

    • Improved Immune Response
    • Improved Growth Performance
    • Improved Immune Organ Development
    • Reduced Odor-Causing Compound Concentrations
    • Reduced Organ Injury from Escherichia coli
    • Reduced Organ Injury from Heat Stress
    • Increased Relative Weight of Immune Organs
    • Alleviated Organ Injury from E. coli O78
    • Alleviated Organ Injury from Heat Stress
    • Reduced Organ Injury
    • Alleviated Organ Injury
    • Increased Organ Weights

    • Low evidence
    • Animal Study
• July 23

  • Oral Probiotic Bifidobacterium Longum Supplementation Improves Metabolic Parameters and Alters the Expression of the Renin-Angiotensin System in Obese Mice Liver

    • 2020-07-23
    • RCT · n = 32
    • Biological Research For Nursing 23(1)
    • • A. S. Machado
      • J. R. Oliveira
      • D. F. Lelis
      • A. D. de Paula
      • A. Guimarães
      • J. Andrade
      • I. Brandi
      • S. Santos

    • PubMed: 32700545
    • DOI: 10.1177/1099800420942942

    5 Insights on

    • Reduced Total Cholesterol Levels
    • Improved Glucose Tolerance
    • Reduced Hepatic Fat Accumulation
    • Reduced Blood Glucose Levels
    • Reduced Adipose Tissue

    • Low evidence
    • Animal Study
• July 24

  • Recovery of Saccharomyces cerevisiae CNCM I-3856 in Vaginal Samples of Healthy Women after Oral Administration

    • 2020-07-24
    • RCT · n = 60
    • Nutrients 12(8)
    • • A. Decherf
      • E. Dehay
      • Mickaël Boyer
      • M. Clément-Ziza
      • B. Rodriguez
      • S. Legrain-Raspaud

    • PubMed: 32722250
    • DOI: 10.3390/nu12082211

    1 Insight on

    • Yeast Migration from Intestine to Vagina

    • High evidence
• July 28

  • Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3) supplementation: A crossover randomized clinical trial.

    • 2020-07-28
    • RCT
    • Clinical & experimental ophthalmology 48(7)
    • • Flora Hui
      • Jessica Tang
      • Pete A Williams
      • Myra B McGuinness
      • Xavier Hadoux
      • Robert J Casson
      • Michael Coote
      • Ian A Trounce
      • Keith R Martin
      • Peter van Wijngaarden
      • Jonathan G Crowston

    • PubMed: 32721104
    • DOI: 10.1111/ceo.13818

    2 Insights on

    • Improved Inner Retinal Function
    • Improved Visual Field Mean Deviation

    • High evidence
    • Highly Cited

  • Protective action of Bacillus clausii probiotic strains in an in vitro model of Rotavirus infection

    • 2020-07-28
    • Scientific Reports 10(1)
    • • L. Paparo
      • L. Tripodi
      • C. Bruno
      • L. Pisapia
      • C. Damiano
      • L. Pastore
      • R. Berni Canani

    • PubMed: 32724066
    • DOI: 10.1038/s41598-020-69533-7

    4 Insights on

    • Improved Intestinal Barrier Function
    • Improved Immunologic Barrier Function
    • Reduced Apoptosis of Jejunal Mucosal Cells
    • Reduced Inflammation Levels

    • Low evidence
    • Rigorous Journal
• July 29

  • Nutrition and Psoriasis.

    • 2020-07-29
    • Review
    • International journal of molecular sciences 21(15)
    • • Naoko Kanda
      • Toshihiko Hoashi
      • Hidehisa Saeki

    • PubMed: 32751360
    • DOI: 10.3390/ijms21155405

    2 Insights on

    • Reduced Psoriasis Symptoms
    • Improved Psoriasis Severity

    • Moderate evidence
    • Rigorous Journal

  • Synbiotic Effect of Bifidobacterium Lactis CNCM I-3446 and Bovine Milk-Derived Oligosaccharides on Infant Gut Microbiota

    • 2020-07-29
    • Nutrients 12(8)
    • • Benoît Marsaux
      • P. van den Abbeele
      • J. Ghyselinck
      • Guénolée Prioult
      • M. Marzorati
      • Biljana Bogičević

    • PubMed: 32751149
    • DOI: 10.3390/nu12082268

    6 Insights on

    • Increased Bifidobacteria Growth
    • Enhanced Bifidobacterial Growth
    • Modulation of Microbiota Activity
    • Increased Microbiota Engraftment
    • Improved Microbiota Activity
    • Enhanced Infant Gut Microbiota by Bifidobacterium lactis

    • Moderate evidence
• July 30

  • Exploring Health-Promoting Attributes of Plant Proteins as a Functional Ingredient for the Food Sector: A Systematic Review of Human Interventional Studies.

    • 2020-07-30
    • Systematic Review
    • Nutrients 12(8)
    • • Marta Lonnie
      • Ieva Laurie
      • Madeleine Myers
      • Graham Horgan
      • Wendy R Russell
      • Alexandra M Johnstone

    • PubMed: 32751677
    • DOI: 10.3390/nu12082291

    9 Insights on

    • Reduced Body Weight
    • Reduced Blood Pressure
    • Reduced Blood Lipid Levels
    • Reduced Appetite
    • Improved Glycemic Response
    • Reduced Postprandial Glycemic Response
    • Improved Satiety
    • Improved Muscle Health
    • Reduced Lipid Level

    • High evidence
    • Rigorous Journal
• July 31

  • Lactobacillus reuteri Ameliorates Intestinal Inflammation and Modulates Gut Microbiota and Metabolic Disorders in Dextran Sulfate Sodium-Induced Colitis in Mice

    • 2020-07-31
    • Clinical Trial
    • Nutrients 12(8)
    • • Gang Wang
      • Shuo Huang
      • S. Cai
      • Haitao Yu
      • Yuming Wang
      • Xiangfang Zeng
      • S. Qiao

    • PubMed: 32751784
    • DOI: 10.3390/nu12082298

    2 Insights on

    • Reduced Intestinal Inflammation
    • Improved Metabolic Health

    • Low evidence
    • Animal Study

  • Impact of Heat-Killed Lactobacillus casei Strain IMAU60214 on the Immune Function of Macrophages in Malnourished Children

    • 2020-07-31
    • Nutrients 12(8)
    • • L. M. Rocha-Ramírez
      • Beatriz Hernández-Ochoa
      • S. Gómez-Manzo
      • J. Marcial-Quino
      • N. Cárdenas-Rodríguez
      • S. Centeno-Leija
      • M. García‐Garibay

    • PubMed: 32751919
    • DOI: 10.3390/nu12082303

    1 Insight on

    • Improved Immune Function

    • Moderate evidence
• Undated – 10 supplement studies

  • Enhancing immunity in viral infections, with special emphasis on COVID-19: A review.

    • 2020-07
    • Systematic Review · n = 640
    • Diabetes & metabolic syndrome 14(4)
    • • Ranil Jayawardena
      • Piumika Sooriyaarachchi
      • Michail Chourdakis
      • Chandima Jeewandara
      • Priyanga Ranasinghe

    • PubMed: 32334392
    • DOI: 10.1016/j.dsx.2020.04.015

    2 Insights on

    • Improved Immune Function
    • Improved Respiratory Infection Resistance

    • High evidence
    • Highly Cited

  • Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial.

    • 2020-07
    • RCT · n = 443
    • The Lancet Gastroenterology & Hepatology 5(7)
    • • V. Andresen
      • J. Gschossmann
      • P. Layer

    • PubMed: 32277872
    • DOI: 10.1016/S2468-1253(20)30056-X

    10 Insights on

    • Reduced Abdominal Pain Severity
    • Improved General IBS Symptoms
    • Reduced Abdominal Pain
    • Improved Tolerability
    • Improved Irritable Bowel Syndrome Symptoms
    • Absence of Adverse Effects
    • Improved Safety Profile
    • Reduced IBS Symptoms
    • Improved Abdominal Pain
    • Improved Overall IBS Symptoms

    • High evidence
    • Large Human Trial
    • Highly Cited
    • Rigorous Journal

  • Fermented Dairy Products, Probiotic Supplementation, and Cardiometabolic Diseases: A Systematic Review and Meta-analysis.

    • 2020-07
    • Meta-Analysis
    • Advances in Nutrition 11(4)
    • • J. Companys
      • L. Pla-Pagà
      • L. Calderón-Pérez
      • E. Llauradó
      • R. Solà
      • A. Pedret
      • R. Valls

    • PubMed: 32277831
    • DOI: 10.1093/advances/nmaa030

    3 Insights on

    • Reduced Cardiovascular Risk
    • Reduced Lipid Concentrations
    • Reduced Anthropometric Parameters

    • High evidence
    • Highly Cited

  • Improvements to postprandial glucose control in subjects with type 2 diabetes: a multicenter, double blind, randomized placebo-controlled trial of a novel probiotic formulation

    • 2020-07
    • RCT · n = 76
    • BMJ Open Diabetes Research & Care 8(1)
    • • Fanny Perraudeau
      • Paul J. McMurdie
      • James H. Bullard
      • Andrew Cheng
      • Colleen Cutcliffe
      • Achal Deo
      • J. Eid
      • Jessica Gines
      • Mohan Iyer
      • N. Justice
      • Wesley T Loo
      • Madeleine Nemchek
      • M. Schicklberger
      • Michael Souza
      • B. Stoneburner
      • Surabhi Tyagi
      • O. Kolterman

    • PubMed: 32675291
    • DOI: 10.1136/bmjdrc-2020-001319

    1 Insight on

    • Improved Postprandial Glucose Levels

    • High evidence
    • Rigorous Journal

  • Effects of single or conjoint administration of lactic acid bacteria as potential probiotics on growth, immune response and disease resistance of snakehead fish (Channa argus).

    • 2020-07
    • RCT · n = 720
    • Fish & Shellfish Immunology 102
    • • Yi‐di Kong
      • Chunshan Gao
      • Xiaoyan Du
      • J. Zhao
      • Min Li
      • Xiaofeng Shan
      • Guiqin Wang

    • PubMed: 32387561
    • DOI: 10.1016/j.fsi.2020.05.003

    2 Insights on

    • Improved Immune Response
    • Enhanced Disease Resistance

    • Low evidence
    • Animal Study

  • In vitro probiotic properties of Pediococcus pentosaceus L1 and its effects on enterotoxigenic Escherichia coli-induced inflammatory responses in porcine intestinal epithelial cells.

    • 2020-07
    • Microbial Pathogenesis 144
    • • Huajuan Yin
      • Pengfei Ye
      • Qingzhi Lei
      • Yandong Cheng
      • Hang Yu
      • Jinjing Du
      • H. Pan
      • Zhenhui Cao

    • PubMed: 32194178
    • DOI: 10.1016/j.micpath.2020.104163

    1 Insight on

    • Reduced Inflammatory Response

    • Low evidence

  • Effects of supplementing yeast fermentate in the feed or drinking water on stress susceptibility, plasma chemistry, cytokine levels, antioxidant status, and stress- and immune-related gene expression of broiler chickens.

    • 2020-07
    • RCT
    • Poultry science 99(7)
    • • Jill R Nelson
      • Eric B Sobotik
      • Giridhar Athrey
      • Gregory S Archer

    • PubMed: 32616224
    • DOI: 10.1016/j.psj.2020.03.037

    3 Insights on

    • Reduced Corticosterone Levels
    • Reduced Stress Response
    • Reduced Heterophil-to-Lymphocyte Ratio

    • Low evidence
    • Animal Study

  • Echinacea can help with Azithromycin in prevention of recurrent tonsillitis in children.

    • 2020-07
    • RCT · n = 100
    • American journal of otolaryngology 41(4)
    • • Osama G Abdel-Naby Awad

    • PubMed: 32487336
    • DOI: 10.1016/j.amjoto.2019.102344

    2 Insights on

    • Reduced Tonsillitis Attack Frequency
    • Reduced Tonsillitis Severity

    • High evidence
    • Large Human Trial

  • Dietary Bacillus amyloliquefaciens enhance survival of white spot syndrome virus infected crayfish.

    • 2020-07
    • Clinical Trial
    • Fish & Shellfish Immunology 102
    • • Y. Lai
      • M. Luo
      • Fei Zhu

    • PubMed: 32325213
    • DOI: 10.1016/j.fsi.2020.04.033

    6 Insights on

    • Reduced Colitis-Related Mortality
    • Increased Superoxide Dismutase Activity
    • Reduced Viral Load
    • Enhanced Phenoloxidase Activity
    • Enhanced Hemocyte Count
    • Reduced Hemocyte Apoptosis

    • Low evidence
    • Animal Study

  • Bifidobacterium animalis subsp. lactis Bi‐07 contributes to increasing lactose digestion: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

    • 2020-07
    • EFSA Journal 18(7)
    • • D. Turck
      • J. Castenmiller
      • S. de Henauw
      • K. Hirsch‐Ernst
      • J. Kearney
      • H. Knutsen
      • A. Maciuk
      • I. Mangelsdorf
      • H. Mcardle
      • A. Naska
      • C. Peláez
      • K. Pentieva
      • F. Thies
      • S. Tsabouri
      • M. Vinceti
      • Jean‐Loui s Bresson
      • A. Siani

    • PubMed: 32742434
    • DOI: 10.2903/j.efsa.2020.6198

    3 Insights on

    • Improved Lactose Digestion
    • Improved Gastrointestinal Symptoms
    • Increased Lactose Digestion

    • Low evidence