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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Macrophage cytokine responses to commensal Gram-positive Lactobacillus salivarius strains are TLR2-independent and Myd88-dependent
- 2021-03-15
- Scientific Reports 11(1)
- - Sreeram Udayan
  - L. Buttó
  - V. Rossini
  - Janaki Velmurugan
  - María Martínez-López
  - D. Sancho
  - S. Melgar
  - P. O’Toole
  - K. Nally
- PubMed: 33723368
- DOI: 10.1038/s41598-021-85347-7
3 Insights on
- Low evidence
- Rigorous Journal
Impact of 2'-Fucosyllactose on Gut Microbiota Composition in Adults with Chronic Gastrointestinal Conditions: Batch Culture Fermentation Model and Pilot Clinical Trial Findings.
- 2021-03-14
- Clinical Trial
- Nutrients 13(3)
- - Jennifer Joan Ryan
  - Andrea Monteagudo-Mera
  - Nikhat Contractor
  - Glenn R Gibson
- PubMed: 33799455
- DOI: 10.3390/nu13030938
3 Insights on
- High evidence
- Rigorous Journal
Effects of dietary Bacillus coagulans and yeast hydrolysate supplementation on growth performance, immune response and intestinal barrier function in weaned piglets.
- 2021-03-14
- RCT · n = 24
- Journal of Animal Physiology and Animal Nutrition 105(5)
- - Runqi Fu
  - Chan Liang
  - Daiwen Chen
  - H. Yan
  - G. Tian
  - P. Zheng
  - Jun He
  - Jie Yu
  - X. Mao
  - Zhiqing Huang
  - Yuheng Luo
  - Junqiu Luo
  - B. Yu
- PubMed: 33715204
- DOI: 10.1111/jpn.13529
13 Insights on
- Low evidence
- Animal Study
An 8-Week Administration of Bifidobacterium bifidum and Lactobacillus plantarum Combined with Exercise Training Alleviates Neurotoxicity of Aβ and Spatial Learning via Acetylcholine in Alzheimer Rat Model
- 2021-03-14
- RCT · n = 25
- Journal of Molecular Neuroscience 71(7)
- - Samaneh Shamsipour
  - G. Sharifi
  - F. Taghian
- PubMed: 33715084
- DOI: 10.1007/s12031-021-01812-y
5 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Dietary Supplementation of Bacillus sp. SJ-10 and Lactobacillus plantarum KCCM 11322 Combinations Enhance Growth and Cellular and Humoral Immunity in Olive Flounder (Paralichthys olivaceus)
- 2021-03-13
- RCT
- Probiotics and Antimicrobial Proteins 13(5)
- - M. T. Hasan
  - W. Jang
  - Bong-Joo Lee
  - Sang-woo Hur
  - S. Lim
  - K. Kim
  - Hyonsob Han
  - Eun-Woo Lee
  - S. Bai
  - I. Kong
- PubMed: 33713023
- DOI: 10.1007/s12602-021-09749-9
7 Insights on
- High evidence
Evaluation of Growth, Viability, Lactic Acid Production and Anti-Infective Effects of Lacticaseibacillus rhamnosus ATCC 9595 in Bacuri Juice (Platonia insignis)
- 2021-03-12
- Foods 10(3)
- - Yasmim Costa Mendes
  - G. P. Mesquita
  - Gabrielle Damasceno Evangelista Costa
  - Ana Carolina Barbosa da Silva
  - E. Gouveia
  - M. Silva
  - V. Monteiro-Neto
  - Rita Miranda
  - Luís Cláudio Nascimento da Silva
  - Adrielle Zagmignan
- PubMed: 33809284
- DOI: 10.3390/foods10030603
2 Insights on
- Increased Survival Rates of Infected Hosts
- Increased Survival Rate Against E. coli Infection
- Low evidence
- Rigorous Journal
Effect of Lactobacillus fermentum MCC2760-Based Probiotic Curd on Hypercholesterolemic C57BL6 Mice
- 2021-03-12
- RCT
- ACS Omega 6(11)
- - Meena Kumari Palani Kumar
  - P. Halami
  - Muthukumar Serva Peddha
- PubMed: 33778280
- DOI: 10.1021/acsomega.1c00045
25 Insights on
- Low evidence
- Animal Study
Effect of L-Carnosine in children with autism spectrum disorders: a systematic review and meta-analysis of randomised controlled trials.
- 2021-03-11
- Meta-Analysis · n = 215
- Amino acids 53(4)
- - Debi Ann Abraham
  - Krishna Undela
  - Udayakumar Narasimhan
  - M G Rajanandh
- PubMed: 33704575
- DOI: 10.1007/s00726-021-02960-6
8 Insights on
- High evidence
The impact of rice bran oil consumption on the serum lipid profile in adults: a systematic review and meta-analysis of randomized controlled trials.
- 2021-03-10
- Meta-Analysis
- Critical reviews in food science and nutrition 62(22)
- - Behnaz Pourrajab
  - Mohammad Hassan Sohouli
  - Ali Amirinejad
  - Somaye Fatahi
  - Mihnea-Alexandru Găman
  - Farzad Shidfar
- PubMed: 33715544
- DOI: 10.1080/10408398.2021.1895062
4 Insights on
- High evidence
A Newly Characterized Potentially Probiotic Strain, Lactobacillus brevis MK05, and the Toxicity Effects of its Secretory Proteins Against MCF-7 Breast Cancer Cells
- 2021-03-09
- Probiotics and Antimicrobial Proteins 13(4)
- - Mona Pourbaferani
  - Sima Modiri
  - A. Norouzy
  - H. Maleki
  - Mohadeseh Heidari
  - L. Alidoust
  - Venus Derakhshan
  - H. Zahiri
  - K. A. Noghabi
- PubMed: 33687634
- DOI: 10.1007/s12602-021-09766-8
3 Insights on
- Low evidence
The Effects of Dietary Supplementation of Lactococcus lactis Strain Plasma on Skin Microbiome and Skin Conditions in Healthy Subjects—A Randomized, Double-Blind, Placebo-Controlled Trial
- 2021-03-09
- RCT · n = 70
- Microorganisms 9(3)
- - R. Tsuji
  - K. Yazawa
  - T. Kokubo
  - Y. Nakamura
  - O. Kanauchi
- PubMed: 33803200
- DOI: 10.3390/microorganisms9030563
4 Insights on
- High evidence
- Rigorous Journal
Application of genus Cassia in the treatment of Constipation: A systematic review.
- 2021-03-08
- Systematic Review
- F1000Research 8
- - Muhammad Shahzad Aslam
- PubMed: 39238530
- DOI: 10.12688/f1000research.17893.2
2 Insights on
- Improved Stool Consistency
- Reduced Pain
- High evidence
Mechanisms for Lactobacillus rhamnosus treatment of intestinal infection by drug-resistant Escherichia coli.
- 2021-03-08
- Food & Function 11(5)
- - Nan Li
  - B. Pang
  - Junjun Li
  - Guanwen Liu
  - Xiaoguang Xu
  - D. Shao
  - C. Jiang
  - Baowei Yang
  - Junling Shi
- PubMed: 32374342
- DOI: 10.1039/d0fo00128g
5 Insights on
- Low evidence
A pilot study of oxidative pathways in MS fatigue: randomized trial of N-acetyl cysteine.
- 2021-03-06
- RCT
- Annals of clinical and translational neurology 8(4)
- - Kristen M Krysko
  - Antje Bischof
  - Bardia Nourbakhsh
  - Roland G Henry
  - Nisha Revirajan
  - Michael Manguinao
  - Khang Nguyen
  - Amit Akula
  - Yan Li
  - Emmanuelle Waubant
- PubMed: 33675156
- DOI: 10.1002/acn3.51325
3 Insights on
- High evidence
A concerted probiotic activity to inhibit periodontitis-associated bacteria
- 2021-03-05
- PLOS ONE 16(3)
- - P. Jansen
  - M. Abdelbary
  - G. Conrads
- PubMed: 33667279
- DOI: 10.1371/journal.pone.0248308
2 Insights on
- Reduced Periodontitis-associated Bacterial Growth
- Enhanced Growth of S. salivarius M18
- Low evidence
- Rigorous Journal
Combination of the Probiotics Lacticaseibacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis, BB-12 Has Limited Effect on Biomarkers of Immunity and Inflammation in Older People Resident in Care Homes: Results From the Probiotics to Reduce Infections iN CarE home reSidentS Randomized, Controlled Trial.
- 2021-03-04
- RCT · n = 30
- Frontiers in immunology 12
- - Vivian M Castro-Herrera
  - Helena L Fisk
  - Mandy Wootton
  - Mark Lown
  - Eleri Owen-Jones
  - Mandy Lau
  - Rachel Lowe
  - Kerenza Hood
  - David Gillespie
  - F D Richard Hobbs
  - Paul Little
  - Christopher C Butler
  - Elizabeth A Miles
  - Philip C Calder
- PubMed: 33746986
- DOI: 10.3389/fimmu.2021.643321
3 Insights on
- High evidence
Effects of a Lactobacilli Probiotic on Reducing Duration of URTI and Fever, and Use of URTI-Associated Medicine: A Re-Analysis of a Randomized, Placebo-Controlled Study
- 2021-03-04
- RCT · n = 109
- Microorganisms 9(3)
- - Tatiana Altadill
  - Jordi Espadaler Mazo
  - M. Liong
- PubMed: 33806508
- DOI: 10.3390/microorganisms9030528
3 Insights on
- High evidence
- Rigorous Journal
A Placebo-Controlled, Pseudo-Randomized, Crossover Trial of Botanical Agents for Gulf War Illness: Curcumin (Curcuma longa), Boswellia (Boswellia serrata), and French Maritime Pine Bark (Pinus pinaster).
- 2021-03-03
- RCT · n = 20
- International journal of environmental research and public health 18(5)
- - Emily K Donovan
  - Sophia Kekes-Szabo
  - Joanne C Lin
  - Rebecca L Massey
  - James D Cobb
  - Kathleen S Hodgin
  - Timothy J Ness
  - Carl Hangee-Bauer
  - Jarred W Younger
- PubMed: 33802272
- DOI: 10.3390/ijerph18052468
1 Insight on
- Reduced Symptom Severity
- High evidence
Clostridium Butyricum ZJU-F1 Benefits the Intestinal Barrier Function and Immune Response Associated with Its Modulation of Gut Microbiota in Weaned Piglets
- 2021-03-02
- RCT · n = 120
- Cells 10(3)
- - Jie Fu
  - Tenghao Wang
  - Xinxin Xiao
  - Yuanzhi Cheng
  - Fengqin Wang
  - M. Jin
  - Yizhen Wang
  - X. Zong
- PubMed: 33801396
- DOI: 10.3390/cells10030527
6 Insights on
- Low evidence
- Animal Study
A tale of caution: prolonged Bacillus clausii bacteraemia after probiotic use in an immunocompetent child
- 2021-03-01
- Case Report · n = 1
- Access Microbiology 3(3)
- - A. Khatri
  - S. Rai
  - C. Shank
  - A. McInerney
  - B. Kaplan
  - Stefan H F Hagmann
  - Mundeep K Kainth
- PubMed: 34151160
- DOI: 10.1099/acmi.0.000205
1 Insight on
- Prolonged Bacteraemia
- Low evidence
Plasmids encode niche-specific traits in Lactobacillaceae.
- 2021-03-01
- Microbial genomics 7(3)
- - Dimple Davray
  - Dipti Deo
  - Ram Kulkarni
- PubMed: 33166245
- DOI: 10.1099/mgen.0.000472
2 Insights on
- Plasmid-Mediated Niche Adaptation in Lactobacillaceae
- Adaptation to Ecological Niches
- Low evidence
Enterococcus faecium R0026 Combined with Bacillus subtilis R0179 Prevent Obesity-Associated Hyperlipidemia and Modulate Gut Microbiota in C57BL/6 Mice
- 2021-02-28
- RCT · n = 40
- Journal of Microbiology and Biotechnology 31(2)
- - Jinli Huang
  - Juan Huang
  - Tianyi Yin
  - Huiyun Lv
  - Pengyu Zhang
  - Huajun Li
- PubMed: 33144552
- DOI: 10.4014/jmb.2009.09005
5 Insights on
- Low evidence
- Animal Study
Examining the Gastrointestinal and Immunomodulatory Effects of the Novel Probiotic Bacillus subtilis DE111
- 2021-02-28
- RCT
- International Journal of Molecular Sciences 22(5)
- - Kimberley E. Freedman
  - Jessica L. Hill
  - Yuren Wei
  - Allegra R. Vazquez
  - Diana S. Grubb
  - Roxanne E. Trotter
  - Scott D. Wrigley
  - Sarah A. Johnson
  - M. Foster
  - T. Weir
- PubMed: 33671071
- DOI: 10.3390/ijms22052453
2 Insights on
- Improved Gastrointestinal Health
- Increased Anti-Inflammatory Immune Cell Populations
- High evidence
Probiotics in Cosmetic and Personal Care Products: Trends and Challenges.
- 2021-02-26
- Review
- Molecules (Basel, Switzerland) 26(5)
- - Scarlett Puebla-Barragan
  - Gregor Reid
- PubMed: 33652548
- DOI: 10.3390/molecules26051249
2 Insights on
- Improved Skin Barrier Function
- Improved Skin Health
- Low evidence
Traditional Bulgarian Dairy Products: Ethnic Foods with Health Benefits.
- 2021-02-25
- Review
- Microorganisms 9(3)
- - Penka Petrova
  - Ivan Ivanov
  - Lidia Tsigoriyna
  - Nadezhda Valcheva
  - Evgenia Vasileva
  - Tsvetomila Parvanova-Mancheva
  - Alexander Arsov
  - Kaloyan Petrov
- PubMed: 33668910
- DOI: 10.3390/microorganisms9030480
5 Insights on
- Low evidence
Safety Assessment of Bacillus subtilis MB40 for Use in Foods and Dietary Supplements
- 2021-02-25
- Clinical Trial
- Nutrients 13(3)
- - Jessica L. Spears
  - R. Kramer
  - A. Nikiforov
  - Marisa O. Rihner
  - E. A. Lambert
- PubMed: 33668992
- DOI: 10.3390/nu13030733
3 Insights on
- High evidence
Efficacy of Bifidobacterium breve CECT7263 for infantile colic treatment: an open-label, parallel, randomised, controlled trial.
- 2021-02-24
- RCT · n = 150
- Beneficial microbes 12(1)
- - J A Maldonado-Lobón
  - R Blanco-Rojo
  - J Maldonado
  - M A Ali
  - M V Almazán
  - A Suanes-Cabello
  - E Callejón
  - R Jaldo
  - M R Benavídes
  - A M Negrillo
  - A Sañudo
  - C Rodríguez
  - O Bañuelos
  - J Fonollá
  - M Olivares
- PubMed: 33350361
- DOI: 10.3920/bm2020.0105
1 Insight on
- Reduced Crying Time
- High evidence
- Large Human Trial
- Rigorous Journal
Efficacy of Bifidobacterium breve CECT7263 for infantile colic treatment: an open-label, parallel, randomised, controlled trial.
- 2021-02-24
- RCT · n = 150
- Beneficial Microbes 12(1)
- - J. Maldonado-Lobón
  - R. Blanco-Rojo
  - J. Maldonado
  - M. A. Ali
  - M. V. Almazán
  - A. Suanes-Cabello
  - E. Callejón
  - R. Jaldo
  - M. R. Benavides
  - A. Negrillo
  - A. Sañudo
  - C. Rodríguez
  - O. Bañuelos
  - J. Fonollá
  - M. Olivares
- PubMed: 33350361
- DOI: 10.3920/BM2020.0105
4 Insights on
- High evidence
Lipoteichoic acid from Bifidobacterium animalis subsp. lactis BPL1: a novel postbiotic that reduces fat deposition via IGF‐1 pathway
- 2021-02-23
- Clinical Trial
- Microbial Biotechnology 15(3)
- - Ferrán Balaguer
  - M. Enrique
  - S. Llopis
  - M. Barrena
  - Verónica Navarro
  - Beatriz Alvarez
  - E. Chenoll
  - D. Ramón
  - M. Tortajada
  - P. Martorell
- PubMed: 33620143
- DOI: 10.1111/1751-7915.13769
1 Insight on
- Reduced Fat Deposition
- Low evidence
- Animal Study
In Vivo Transcriptome of Lactobacillus acidophilus and Colonization Impact on Murine Host Intestinal Gene Expression
- 2021-02-23
- mBio 12(1)
- - Y. Goh
  - R. Barrangou
  - T. Klaenhammer
- PubMed: 33500337
- DOI: 10.1128/mBio.03399-20
11 Insights on
- Low evidence