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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

The Effect of Local Application of Tea Tree Oil Adjunctive to Daily Oral Maintenance and Nonsurgical Periodontal Treatment: A Systematic Review and Meta-Analysis of Randomised Controlled Studies.
- 2024-06-12
- Meta-Analysis
- Oral health & preventive dentistry 22
- - Chenjiao Zhang
  - Bowen Liu
  - Jingchao Hu
  - Li Zhao
  - Han Zhao
- PubMed: 38864380
- DOI: 10.3290/j.ohpd.b5458585
3 Insights on
- High evidence
The Effect of Sargassum fusiforme and Fucus vesiculosus on Continuous Glucose Levels in Overweight Patients with Type 2 Diabetes Mellitus: A Feasibility Randomized, Double-Blind, Placebo-Controlled Trial.
- 2024-06-12
- RCT · n = 12
- Nutrients 16(12)
- - Karlijn A M Geurts
  - Sjoerd Meijer
  - Jeanine E Roeters van Lennep
  - Xi Wang
  - Behiye Özcan
  - Gardi Voortman
  - Hongbing Liu
  - Manuel Castro Cabezas
  - Kirsten A Berk
  - Monique T Mulder
- PubMed: 38931192
- DOI: 10.3390/nu16121837
1 Insight on
- Reduced Blood Glucose Levels
- High evidence
- Rigorous Journal
Sex differences in the effects of aromatherapy on anxiety and salivary oxytocin levels.
- 2024-06-11
- RCT · n = 15
- Frontiers in endocrinology 15
- - Daisuke Nakajima
  - Megumi Yamachi
  - Shingen Misaka
  - Kenju Shimomura
  - Yuko Maejima
- PubMed: 38919481
- DOI: 10.3389/fendo.2024.1380779
2 Insights on
- Reduced Anxiety Levels
- Increased Salivary Oxytocin Level
- High evidence
Citrus depressa peel extract acts as a prebiotic to reduce lipid accumulation and modulate gut microbiota in obese mice.
- 2024-06-10
- Journal of food and drug analysis 32(2)
- - Zheng-Yuan Su
  - Jie-An Liao
  - Ching-Ting Lin
  - Guor-Jien Wei
  - Yen-Chen Tung
- PubMed: 38934690
- DOI: 10.38212/2224-6614.3504
3 Insights on
- Low evidence
Saccharomyces boulardii combined with triple therapy alter the microbiota in the eradication of Helicobacter pylori infection.
- 2024-06-07
- RCT · n = 144
- Scientific reports 14(1)
- - Yan Zhang
  - Bingyun Lu
  - Yu Dong
  - Yifeng Zhang
  - Qianming Du
  - Ye Chen
  - Zhenyu Zhang
- PubMed: 38849408
- DOI: 10.1038/s41598-024-63894-z
2 Insights on
- Reduced Abdominal Pain
- Increased Helicobacter pylori Eradication Rate
- High evidence
- Large Human Trial
- Rigorous Journal
The effect of psyllium on fasting blood sugar, HbA1c, HOMA IR, and insulin control: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials.
- 2024-06-06
- Meta-Analysis · n = 962
- BMC endocrine disorders 24(1)
- - Zeinab Gholami
  - Cain C T Clark
  - Zamzam Paknahad
- PubMed: 38844885
- DOI: 10.1186/s12902-024-01608-2
1 Insight on
- Reduced Hemoglobin A1c
- High evidence
The effects of vitamin D supplementation on serum lipid profiles in people with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.
- 2024-06-05
- Systematic Review · n = 1,711
- Frontiers in nutrition 11
- - Qingyang Lu
  - Qingyue Liang
  - Yue Xi
- PubMed: 38903615
- DOI: 10.3389/fnut.2024.1419747
4 Insights on
- High evidence
Effect of blueberry intervention on endothelial function: a systematic review and meta-analysis.
- 2024-06-03
- Systematic Review
- Frontiers in physiology 15
- - Bixin Deng
  - Yupeng Lei
  - Ruixi Zhou
  - Tiechao Ruan
  - Wenting Lu
  - Junjie Ying
  - Yan Yue
  - Dezhi Mu
- PubMed: 38887319
- DOI: 10.3389/fphys.2024.1368892
3 Insights on
- High evidence
Recent Advances in the Understanding of Stress Resistance Mechanisms in Probiotics: Relevance for the Design of Functional Food Systems.
- 2024-06-03
- Review
- Probiotics and antimicrobial proteins 17(1)
- - Ana Yanina Bustos
  - María Pía Taranto
  - Carla Luciana Gerez
  - Sofia Agriopoulou
  - Slim Smaoui
  - Theodoros Varzakas
  - Hesham Ali El Enshasy
- PubMed: 38829565
- DOI: 10.1007/s12602-024-10273-9
3 Insights on
- Moderate evidence
- Rigorous Journal
Characterization of Antimicrobial Activities of Bifidobacterium lactis BB-12 and Their Inhibitory Effect Against Some Foodborne Pathogens.
- 2024-06-01
- Foodborne pathogens and disease 21(6)
- - Fatemeh Roozbahani
  - Mohammad Ahanjan
  - Mona Moshiri
  - Saeid Abediankenari
  - Hamid Reza Goli
  - Maedeh Kakavan
  - Mehrdad Gholami
- PubMed: 38578010
- DOI: 10.1089/fpd.2023.0182
2 Insights on
- Reduced Pathogen Growth
- Reduced Salmonella Typhimurium Activity
- Low evidence
A Randomized Single-Blinded Phase II Trial Comparing Efficacy and Quality of Life of Topical Aloe Vera Gel Plus Urea Cream Versus Urea Cream Alone for Prevention of Hand Foot Syndrome in Cancer Patients Receiving Capecitabine.
- 2024-06-01
- RCT · n = 31
- Asian Pacific journal of cancer prevention : APJCP 25(6)
- - Lucksika Wanichtanom
  - Gorn Vrakornvoravuti
  - Metavee Boonsiri
  - Apisada Suthepwanon
- PubMed: 38918684
- DOI: 10.31557/apjcp.2024.25.6.2203
2 Insights on
- Improved Quality of Life
- Reduced Hand Foot Syndrome Severity
- High evidence
The Health Benefits of Probiotic Lactiplantibacillus plantarum: A Systematic Review and Meta-Analysis.
- 2024-05-31
- Meta-Analysis
- Probiotics and antimicrobial proteins 17(5)
- - Amal Aljohani
  - Noha Rashwan
  - Shruti Vasani
  - Ahmed Alkhawashki
  - Tong Tong Wu
  - Xingyi Lu
  - Daniel A Castillo
  - Jin Xiao
- PubMed: 38816672
- DOI: 10.1007/s12602-024-10287-3
9 Insights on
- High evidence
- Rigorous Journal
The Effects of a Dietary Supplement (PediaFlù) Plus Standard of Care in Children With Acute Tonsillopharyngitis/Rhinopharyngitis: Protocol for a Randomized Controlled Trial.
- 2024-05-31
- RCT · n = 150
- JMIR research protocols 13
- - Fabio Cardinale
  - Dionisio Franco Barattini
  - Federica Sbrocca
  - Alessandro Centi
  - Greta Giuntini
  - Maria Morariu Bordea
  - Dorina Herteg
  - Serban Rosu
  - Cristian Radu Matei
- PubMed: 38819917
- DOI: 10.2196/53703
2 Insights on
- Reduced Tonsillitis Severity
- Reduced Treatment Failure
- High evidence
- Large Human Trial
Identification of a Novel Aflatoxin B1-Degrading Strain, Bacillus halotolerans DDC-4, and Its Response Mechanisms to Aflatoxin B1.
- 2024-05-31
- Toxins 16(6)
- - Jia Guo
  - Hanlu Zhang
  - Yixuan Zhao
  - Xiaoxu Hao
  - Yu Liu
  - Suhong Li
  - Rina Wu
- PubMed: 38922150
- DOI: 10.3390/toxins16060256
2 Insights on
- Reduced Stress Response
- Improved Aflatoxin B1 Degradation
- Low evidence
Moringa oleifera leaf extracts improve exercise performance in young male adults: A pilot study.
- 2024-05-31
- RCT · n = 23
- Phytomedicine : international journal of phytotherapy and phytopharmacology 131
- - Weiyun Dong
  - Xiangyu Bian
  - Min Wan
  - Lu Jin
  - Yanxian Wang
  - Che Jing
  - Zhanxin Yao
  - Weina Gao
  - Zhuge Xi
  - Changjiang Guo
- PubMed: 38852476
- DOI: 10.1016/j.phymed.2024.155751
6 Insights on
- High evidence
Bifidobacterium adolescentis SBT2786 Improves Sleep Quality in Japanese Adults with Relatively High Levels of Stress: A Randomized, Double-Blind, Placebo-Controlled Study.
- 2024-05-30
- RCT · n = 65
- Nutrients 16(11)
- - Hiroki Murakami
  - Taro Ko
  - Haruka Ouchi
  - Toshiharu Namba
  - Shukuko Ebihara
  - Shunjiro Kobayashi
- PubMed: 38892634
- DOI: 10.3390/nu16111702
3 Insights on
- High evidence
- Rigorous Journal
Behavioral transcriptomic effects of triploidy and probiotic therapy (Bifidobacterium, Lactobacillus, and Lactococcus mixture) on juvenile Chinook salmon (Oncorhynchus tshawytscha).
- 2024-05-30
- Clinical Trial · n = 360
- Genes, brain, and behavior 23(3)
- - Chelsea E Frank
  - Javad Sadeghi
  - Daniel D Heath
  - Christina A D Semeniuk
- PubMed: 38817102
- DOI: 10.1111/gbb.12898
1 Insight on
- No Human Health Outcome Reported
- Low evidence
- Animal Study
The efficacy of herbal medicines on the length of stay and negative conversion time/rate outcomes in patients with COVID-19: a systematic review.
- 2024-05-30
- Systematic Review · n = 19
- Frontiers in pharmacology 15
- - Irma Rahayu Latarissa
  - Anna Meiliana
  - Ida Paulina Sormin
  - Erizal Sugiono
  - Nasrul Wathoni
  - Melisa Intan Barliana
  - Keri Lestari
- PubMed: 38873430
- DOI: 10.3389/fphar.2024.1383359
3 Insights on
- High evidence
Efficacy and acceptability of different probiotic products plus laxatives for pediatric functional constipation: a network meta-analysis of randomized controlled trials.
- 2024-05-29
- Meta-Analysis · n = 710
- European journal of pediatrics 183(8)
- - Wei-Chieh Yang
  - Bing-Syuan Zeng
  - Chih-Sung Liang
  - Chih-Wei Hsu
  - Kuan-Pin Su
  - Yi-Cheng Wu
  - Yu-Kang Tu
  - Pao-Yen Lin
  - Brendon Stubbs
  - Tien-Yu Chen
  - Yen-Wen Chen
  - Yow-Ling Shiue
  - Bing-Yan Zeng
  - Mein-Woei Suen
  - Chao-Ming Hung
  - Ming-Kung Wu
  - Ping-Tao Tseng
- PubMed: 38806862
- DOI: 10.1007/s00431-024-05568-6
5 Insights on
- High evidence
The Effect of Microbiome-Modulating Agents (MMAs) on Type 1 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- 2024-05-29
- Meta-Analysis
- Nutrients 16(11)
- - Ying Zhang
  - Aiying Huang
  - Jun Li
  - William Munthali
  - Saiying Cao
  - Ulfah Mahardika Pramono Putri
  - Lina Yang
- PubMed: 38892608
- DOI: 10.3390/nu16111675
1 Insight on
- Improved Glycemia
- High evidence
- Rigorous Journal
Effects of Garlic on Glucose Parameters and Lipid Profile: A Systematic Review and Meta-Analysis on Randomized Controlled Trials.
- 2024-05-29
- Meta-Analysis
- Nutrients 16(11)
- - Xinyu Zhao
  - Tao Cheng
  - Hui Xia
  - Yanhong Yang
  - Shaokang Wang
- PubMed: 38892625
- DOI: 10.3390/nu16111692
6 Insights on
- High evidence
- Rigorous Journal
Dietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies.
- 2024-05-29
- Meta-Analysis · n = 558
- Nutrition reviews 83(2)
- - Zahra Hajhashemy
  - Fatemeh Shirani
  - Gholamreza Askari
- PubMed: 38812090
- DOI: 10.1093/nutrit/nuae056
1 Insight on
- Reduced Depression Risk
- High evidence
Effects of vitamin D3 supplementation on strength of lower and upper extremities in athletes: an updated systematic review and meta-analysis of randomized controlled trials.
- 2024-05-27
- Systematic Review
- Frontiers in nutrition 11
- - Qi Han
  - Mai Xiang
  - Nan An
  - Qiushi Tan
  - Jing Shao
  - Qirong Wang
- PubMed: 38860160
- DOI: 10.3389/fnut.2024.1381301
9 Insights on
- High evidence
Silibinin as a major component of milk thistle seed provides promising influences against diabetes and its complications: a systematic review.
- 2024-05-27
- Systematic Review
- Naunyn-Schmiedeberg's archives of pharmacology 397(10)
- - Parisa Zare Mehrjerdi
  - Sara Asadi
  - Elham Ehsani
  - Vahid Reza Askari
  - Vafa Baradaran Rahimi
- PubMed: 38801454
- DOI: 10.1007/s00210-024-03172-x
15 Insights on
- High evidence
Comparing the efficacy of a novel mucoadhesive patch containing Nigella sativa 10% with triamcinolone 0.1% in patients with erosive-atrophic oral lichen planus: A pilot study.
- 2024-05-26
- Clinical Trial · n = 10
- Clinical and experimental dental research 10(3)
- - Atessa Pakfetrat
  - Zahra Delavarian
  - Mahshid Malakooti
  - Hossein Bagheri
  - Habibollah Esmaily
  - Mahsa Ghorbani
  - Pooya Saeedi
- PubMed: 38798063
- DOI: 10.1002/cre2.886
3 Insights on
- Moderate evidence
Effects of Crocus sativus on glycemic control and cardiometabolic parameters among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials.
- 2024-05-25
- Review · n = 840
- Nutrition & metabolism 21(1)
- - Xiaodan Yan
  - Shuyuan Zhao
  - Xue Feng
  - Xinrui Li
  - Qian Zhou
  - Qiu Chen
- PubMed: 38796446
- DOI: 10.1186/s12986-024-00806-y
4 Insights on
- High evidence
Probiotics in Wound Healing.
- 2024-05-24
- Review
- International journal of molecular sciences 25(11)
- - Valentina Alexandra Bădăluță
  - Carmen Curuțiu
  - Lia Mara Dițu
  - Alina Maria Holban
  - Veronica Lazăr
- PubMed: 38891909
- DOI: 10.3390/ijms25115723
1 Insight on
- Improved Wound Healing
- Moderate evidence
- Rigorous Journal
Comparative efficacy of tocotrienol and tocopherol (vitamin E) on atherosclerotic cardiovascular diseases in humans.
- 2024-05-24
- Systematic Review
- JPMA. The Journal of the Pakistan Medical Association 74(6)
- - Saima Rafique
  - Dilshad Ahmed Khan
  - Kulsoom Farhat
  - Muhammad Asghar Khan
  - Mudassar Noor
  - Mahjabeen Sharif
- PubMed: 38948984
- DOI: 10.47391/jpma.9227
8 Insights on
- High evidence
Efficacy and safety of vitamin C supplementation in the treatment of community-acquired pneumonia: a systematic review and meta-analysis with trial sequential analysis.
- 2024-05-24
- Meta-Analysis
- Scientific reports 14(1)
- - Yogesh Sharma
  - Subodha Sumanadasa
  - Rashmi Shahi
  - Richard Woodman
  - Arduino A Mangoni
  - Shailesh Bihari
  - Campbell Thompson
- PubMed: 38783029
- DOI: 10.1038/s41598-024-62571-5
4 Insights on
- High evidence
- Rigorous Journal
Efficacy of Probiotic Strains Lactobacillus sakei Probio65 and Lactobacillus plantarum Probio-093 in Management of Obesity: An In Vitro and In Vivo Analysis.
- 2024-05-24
- Pharmaceuticals (Basel, Switzerland) 17(6)
- - Aneela Gulnaz
  - Lee-Ching Lew
  - Yong-Ha Park
  - Jamal S M Sabir
  - Raed Albiheyri
  - Irfan A Rather
  - Yan-Yan Hor
- PubMed: 38931347
- DOI: 10.3390/ph17060676
1 Insight on
- Improved Adipocyte Inflammatory Profile
- Low evidence