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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Effects of Bacillus subtilis DSM32315 supplementation and dietary crude protein level on performance, gut barrier function and microbiota profile in weaned piglets1.
- 2019-03-18
- RCT
- Journal of Animal Science 97(5)
- - Wenjie Tang
  - Ye Qian
  - B. Yu
  - Zhang Tao
  - Jun Gao
  - Jun He
  - Zhiqing Huang
  - P. Zheng
  - X. Mao
  - Junqiu Luo
  - Jie Yu
  - Daiwen Chen
- PubMed: 30883644
- DOI: 10.1093/jas/skz090
5 Insights on
- High evidence
- Rigorous Journal
Therapeutic Prospective of a Spore-Forming Probiotic—Bacillus clausii UBBC07 Against Acetaminophen-Induced Uremia in Rats
- 2019-03-16
- RCT · n = 18
- Probiotics and Antimicrobial Proteins 12(1)
- - C. Patel
  - Priyanshi Patel
  - S. Acharya
- PubMed: 30879230
- DOI: 10.1007/s12602-019-09540-x
4 Insights on
- Low evidence
- Animal Study
Comparison of the effect of regular and probiotic cake (Bacillus coagulans) on salivary pH and Streptococcus mutans count.
- 2019-03-15
- RCT
- Dental and medical problems 56(1)
- - Maryam Koopaie
  - Mahnaz Fatahzadeh
  - Sana Jahangir
  - Ronak Bakhtiari
- PubMed: 30875151
- DOI: 10.17219/dmp/99757
2 Insights on
- Reduced Mutans Streptococcus Counts
- Increased Salivary pH
- High evidence
Efficacy and Safety of Serenoa repens Extract Among Patients with Benign Prostatic Hyperplasia in China: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial.
- 2019-03-14
- RCT · n = 354
- Urology 129
- - Zhangqun Ye
  - Jian Huang
  - Liqun Zhou
  - Shan Chen
  - Zengjun Wang
  - Lulin Ma
  - Dongfang Wang
  - Gongxian Wang
  - Shusheng Wang
  - Chaozhao Liang
  - Shaopeng Qiu
  - Xiaojian Gu
  - Jianhe Liu
  - Zhiliang Weng
  - Changli Wu
  - Qiang Wei
  - Liping Xie
  - Weizhen Wu
  - Yue Cheng
  - Jingqian Hu
  - Zhixian Wang
  - Xiaoyong Zeng
- PubMed: 30880074
- DOI: 10.1016/j.urology.2019.02.030
10 Insights on
- High evidence
- Large Human Trial
Effects of long-term administration of Lactobacillus reuteri DSM-17938 on circulating levels of 5-HT and BDNF in adults with functional constipation.
- 2019-03-13
- RCT · n = 56
- Beneficial Microbes 10(2)
- - G. Riezzo
  - G. Chimienti
  - A. Orlando
  - B. D’Attoma
  - C. Clemente
  - F. Russo
- PubMed: 30574801
- DOI: 10.3920/BM2018.0050
3 Insights on
- High evidence
Bacillus clausii UBBC-07 reduces severity of diarrhoea in children under 5 years of age: a double blind placebo controlled study.
- 2019-03-13
- RCT
- Beneficial Microbes 10(2)
- - M. Sudha
  - N. Jayanthi
  - D. Pandey
  - A. Verma
- PubMed: 30638396
- DOI: 10.3920/BM2018.0094
4 Insights on
- High evidence
Bifidobacterium infantis M-63 improves mental health in victims with irritable bowel syndrome developed after a major flood disaster.
- 2019-03-13
- RCT · n = 53
- Beneficial Microbes 10(2)
- - Z. F. Ma
  - N. Yusof
  - N. Hamid
  - R. M. Lawenko
  - W. M. Z. W. Mohammad
  - M. Liong
  - H. Sugahara
  - T. Odamaki
  - J. Xiao
  - Y. Y. Lee
- PubMed: 30525951
- DOI: 10.3920/BM2018.0008
5 Insights on
- High evidence
Green cardamom supplementation improves serum irisin, glucose indices, and lipid profiles in overweight or obese non-alcoholic fatty liver disease patients: a double-blind randomized placebo-controlled clinical trial.
- 2019-03-12
- RCT · n = 87
- BMC complementary and alternative medicine 19(1)
- - Milad Daneshi-Maskooni
  - Seyed Ali Keshavarz
  - Mostafa Qorbani
  - Siavash Mansouri
  - Seyed Moayed Alavian
  - Mahtab Badri-Fariman
  - Seyed Ali Jazayeri-Tehrani
  - Gity Sotoudeh
- PubMed: 30871514
- DOI: 10.1186/s12906-019-2465-0
11 Insights on
- High evidence
Effect of oral supplementation of probiotic strains of Lactobacillus rhamnosus and Enterococcus faecium on the composition of the faecal microbiota of foals.
- 2019-03-10
- RCT · n = 34
- Journal of Animal Physiology and Animal Nutrition 103(3)
- - V. Urubschurov
  - Christina Stroebel
  - Elena Günther
  - K. Romanowski
  - K. Büsing
  - A. Zeyner
- PubMed: 30854744
- DOI: 10.1111/jpn.13079
1 Insight on
- Maintained Bacterial Diversity
- Low evidence
- Animal Study
Safety Assessment of Potential Probiotic Lactobacillus fermentum MTCC-5898 in Murine Model after Repetitive Dose for 28 Days (Sub-Acute Exposure)
- 2019-03-08
- Clinical Trial
- Probiotics and Antimicrobial Proteins 12(1)
- - M. Samtiya
  - M. I. Bhat
  - Taruna Gupta
  - S. Kapila
  - R. Kapila
- PubMed: 30847835
- DOI: 10.1007/s12602-019-09529-6
3 Insights on
- Low evidence
- Animal Study
Efficacy of Anise (Pimpinella anisum L.) oil for migraine headache: A pilot randomized placebo-controlled clinical trial.
- 2019-03-07
- RCT
- Journal of ethnopharmacology 236
- - Seyed Hamdollah Mosavat
  - Abbas Rahimi Jaberi
  - Zahra Sobhani
  - Maryam Mosaffa-Jahromi
  - Aida Iraji
  - Amin Moayedfard
- PubMed: 30853645
- DOI: 10.1016/j.jep.2019.01.047
3 Insights on
- High evidence
Bacillus amyloliquefaciens BLCC1-0238 Can Effectively Improve Laying Performance and Egg Quality Via Enhancing Immunity and Regulating Reproductive Hormones of Laying Hens
- 2019-03-05
- RCT · n = 240
- Probiotics and Antimicrobial Proteins 12(1)
- - Yufa Zhou
  - Song Li
  - Quanhai Pang
  - Z. Miao
- PubMed: 30834486
- DOI: 10.1007/s12602-019-9524-1
3 Insights on
- Low evidence
- Animal Study
Probiotic characterization of Lactobacillus brevis KU15153 showing antimicrobial and antioxidant effect isolated from kimchi
- 2019-03-04
- Food Science and Biotechnology 28(5)
- - H. Jang
  - N. Lee
  - H. Paik
- PubMed: 31695951
- DOI: 10.1007/S10068-019-00576-X
7 Insights on
- Low evidence
Saccharomyces boulardii CNCM I-745 Modulates the Fecal Bile Acids Metabolism During Antimicrobial Therapy in Healthy Volunteers
- 2019-03-04
- RCT
- Frontiers in Microbiology 10
- - C. Kelly
  - Caroline Chong Nguyen
  - L. Palmieri
  - K. Pallav
  - S. Dowd
  - L. Humbert
  - P. Seksik
  - A. Bado
  - B. Coffin
  - D. Rainteau
  - T. Kabbani
  - H. Duboc
- PubMed: 30881353
- DOI: 10.3389/fmicb.2019.00336
3 Insights on
- High evidence
Nutraceutical approach for the management of cardiovascular risk – a combination containing the probiotic Bifidobacterium longum BB536 and red yeast rice extract: results from a randomized, double-blind, placebo-controlled study
- 2019-02-22
- RCT
- Nutrition Journal 18(1)
- - M. Ruscica
  - C. Pavanello
  - S. Gandini
  - C. Macchi
  - M. Botta
  - Daria Dall’Orto
  - M. Del Puppo
  - M. Bertolotti
  - R. Bosisio
  - Giuliana Mombelli
  - C. Sirtori
  - L. Calabresi
  - P. Magni
- PubMed: 30795775
- DOI: 10.1186/s12937-019-0438-2
6 Insights on
- High evidence
Supplementation of a Lactobacillus acidophilus fermentation product can attenuate the acute phase response following a lipopolysaccharide challenge in weaned pigs.
- 2019-02-22
- RCT
- Animal 13(1)
- - N. B. Sanchez
  - J. Carroll
  - P. R. Broadway
  - B. Bass
  - Jason W. Frank
- PubMed: 29921343
- DOI: 10.1017/S1751731118001222
4 Insights on
- High evidence
- Rigorous Journal
An overview of the phytoestrogen effect on vaginal health and dyspareunia in peri- and post-menopausal women.
- 2019-02-20
- Review
- Post reproductive health 25(1)
- - Fatemeh R Dizavandi
  - Masoumeh Ghazanfarpour
  - Nasibeh Roozbeh
  - Leila Kargarfard
  - Talat Khadivzadeh
  - Sareh Dashti
- PubMed: 30786797
- DOI: 10.1177/2053369118823365
11 Insights on
- Low evidence
Protective effects of triple fermented barley extract (FBe) on indomethacin-induced gastric mucosal damage in rats.
- 2019-02-20
- BMC complementary and alternative medicine 19(1)
- - Jong-Min Lim
  - Chang-Hyun Song
  - Su-Jin Park
  - Dong-Chan Park
  - Go-Woon Jung
  - Hyung-Rae Cho
  - Khawaja Muhammad Imran Bashir
  - Sae Kwang Ku
  - Jae-Suk Choi
- PubMed: 30786935
- DOI: 10.1186/s12906-019-2457-0
6 Insights on
- Low evidence
- Animal Study
Effects of a Saccharomyces cerevisiae fermentation product on fecal characteristics, nutrient digestibility, fecal fermentative end-products, fecal microbial populations, immune function, and diet palatability in adult dogs1.
- 2019-02-16
- RCT
- Journal of Animal Science 97(4)
- - Ching-Yen Lin
  - Celeste Alexander
  - A. Steelman
  - C. Warzecha
  - M. D. de Godoy
  - K. Swanson
- PubMed: 30770927
- DOI: 10.1093/jas/skz064
6 Insights on
- High evidence
- Rigorous Journal
Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a oral spray for children with recurrent streptococcal pharyngotonsillitis: a randomized placebo-controlled clinical study
- 2019-02-15
- RCT · n = 41
- European Archives of Oto-Rhino-Laryngology 276(3)
- - C. Andaloro
  - M. Santagati
  - S. Stefani
  - I. La Mantia
- PubMed: 30767047
- DOI: 10.1007/s00405-019-05346-3
5 Insights on
- High evidence
- Rigorous Journal
Prevention of Recurrent Acute Otitis Media in Children Through the Use of Lactobacillus salivarius PS7, a Target-Specific Probiotic Strain
- 2019-02-12
- Clinical Trial · n = 61
- Nutrients 11(2)
- - Nívia Cárdenas
  - V. Martín
  - Rebeca Arroyo
  - M. López
  - M. Carrera
  - C. Badiola
  - E. Jiménez
  - J. M. Rodríguez
- PubMed: 30759799
- DOI: 10.3390/nu11020376
1 Insight on
- Reduced Acute Otitis Media
- High evidence
Lactobacillus sakei Alleviates High‐Fat‐Diet‐Induced Obesity and Anxiety in Mice by Inducing AMPK Activation and SIRT1 Expression and Inhibiting Gut Microbiota‐Mediated NF‐&kgr;B Activation
- 2019-02-11
- Clinical Trial
- Molecular Nutrition & Food Research 63(6)
- - H. Jang
  - Sang-Kap Han
  - Jeon-Kyung Kim
  - Seong‐Jun Oh
  - Hwan Jang
  - Dong-Hyun Kim
- PubMed: 30636176
- DOI: 10.1002/mnfr.201800978
5 Insights on
- Low evidence
- Animal Study
Spores of Bacillus coagulans GBI-30, 6086 show high germination, survival and enzyme activity in a dynamic, computer-controlled in vitro model of the gastrointestinal tract.
- 2019-02-08
- Beneficial Microbes 10(1)
- - D. Keller
  - Sanne Verbruggen
  - H. Cash
  - S. Farmer
  - Koen Venema
- PubMed: 30694101
- DOI: 10.3920/BM2018.0037
7 Insights on
- Low evidence
Evidence-based mixture containing Lactobacillus strains and lactoferrin to prevent recurrent bacterial vaginosis: a double blind, placebo controlled, randomised clinical trial.
- 2019-02-08
- RCT
- Beneficial microbes 10(1)
- - R Russo
  - E Karadja
  - F De Seta
- PubMed: 30525953
- DOI: 10.3920/bm2018.0075
4 Insights on
- High evidence
- Rigorous Journal
Eczema-protective probiotic alters infant gut microbiome functional capacity but not composition: sub-sample analysis from a RCT.
- 2019-02-08
- RCT · n = 474
- Beneficial microbes 10(1)
- - R Murphy
  - X C Morgan
  - X Y Wang
  - K Wickens
  - G Purdie
  - P Fitzharris
  - A Otal
  - B Lawley
  - T Stanley
  - C Barthow
  - J Crane
  - E A Mitchell
  - G W Tannock
- PubMed: 30574802
- DOI: 10.3920/bm2017.0191
1 Insight on
- Reduced Eczema Risk
- High evidence
- Large Human Trial
- Rigorous Journal
The Beneficial Effects of Lactobacillus plantarum PS128 on High-Intensity, Exercise-Induced Oxidative Stress, Inflammation, and Performance in Triathletes
- 2019-02-07
- RCT
- Nutrients 11(2)
- - Wen-Ching Huang
  - C. Wei
  - Chi-Chang Huang
  - Wen‐Lin Chen
  - Hui-Yu Huang
- PubMed: 30736479
- DOI: 10.3390/nu11020353
4 Insights on
- High evidence
- Highly Cited
Lactobacillus plantarum PFM 105 Promotes Intestinal Development Through Modulation of Gut Microbiota in Weaning Piglets
- 2019-02-05
- Clinical Trial
- Frontiers in Microbiology 10
- - Tianwei Wang
  - Kunling Teng
  - Yayong Liu
  - Weixiong Shi
  - Jie Zhang
  - Enqiu Dong
  - Xin Zhang
  - Yong Tao
  - Jin Zhong
- PubMed: 30804899
- DOI: 10.3389/fmicb.2019.00090
10 Insights on
- Low evidence
- Highly Cited
- Animal Study
Outcomes of Perilla Seed Oil as an Additional Neuroprotective Therapy in Patients with Mild to Moderate Dementia: A Randomized Control Trial.
- 2019-02-04
- RCT · n = 182
- Current Alzheimer research 16(2)
- - Chuntida Kamalashiran
  - Kusuma Sriyakul
  - Junya Pattaraarchachai
  - Sombat Muengtaweepongsa
- PubMed: 30543172
- DOI: 10.2174/1567205016666181212153720
3 Insights on
- High evidence
- Large Human Trial
Efficacy and Safety of Lactobacillus Plantarum C29-Fermented Soybean (DW2009) in Individuals with Mild Cognitive Impairment: A 12-Week, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Clinical Trial
- 2019-02-01
- RCT · n = 100
- Nutrients 11(2)
- - Yun-Ha Hwang
  - Shinwon Park
  - J. Paik
  - S. Chae
  - Dong-Hyun Kim
  - Doc-Gyun Jeong
  - Eunji Ha
  - Myeongju Kim
  - Gahae Hong
  - Soo-Hyun Park
  - Su-Jin Jung
  - Sang-Min Lee
  - Kyu-Heum Na
  - Jungyoon Kim
  - Young-Chul Chung
- PubMed: 30717153
- DOI: 10.3390/nu11020305
3 Insights on
- High evidence
- Highly Cited
Mechanisms underlying effects of kiwifruit on intestinal function shown by MRI in healthy volunteers.
- 2019-01-31
- RCT
- Alimentary pharmacology & therapeutics 49(6)
- - Victoria Wilkinson-Smith
  - Neele Dellschaft
  - Juliet Ansell
  - Caroline Hoad
  - Luca Marciani
  - Penny Gowland
  - Robin Spiller
- PubMed: 30706488
- DOI: 10.1111/apt.15127
7 Insights on
- High evidence
- Rigorous Journal