June 2017 Supplement Research Papers

• June 1

  • Association of Dietary Vitamin K1 Intake With the Incidence of Cataract Surgery in an Adult Mediterranean Population: A Secondary Analysis of a Randomized Clinical Trial.

    • 2017-06-01
    • RCT · n = 5,860
    • JAMA ophthalmology 135(6)
    • • María L Camacho-Barcia
      • Mònica Bulló
      • Jesús F Garcia-Gavilán
      • Miguel Ruiz-Canela
      • Dolores Corella
      • Ramón Estruch
      • Montserrat Fitó
      • Alfredo García-Layana
      • Fernando Arós
      • Miquel Fiol
      • José Lapetra
      • Lluis Serra-Majem
      • Xavier Pintó
      • Ana García-Arellano
      • Ernest Vinyoles
      • José Vicente Sorli
      • Jordi Salas-Salvadó

    • PubMed: 28494067
    • DOI: 10.1001/jamaophthalmol.2017.1076

    1 Insight on

    • Reduced Cataract Incidence

    • High evidence
    • Large Human Trial
• June 2

  • The regulation of immune cells by Lactobacilli: a potential therapeutic target for anti-atherosclerosis therapy.

    • 2017-06-02
    • Review
    • Oncotarget 8(35)
    • • Ya-Hui Ding
      • Lin-Yan Qian
      • Jie Pang
      • Jing-Yang Lin
      • Qiang Xu
      • Li-Hong Wang
      • Dong-Sheng Huang
      • Hai Zou

    • PubMed: 28938693
    • DOI: 10.18632/oncotarget.18346

    2 Insights on

    • Modulated Immune Response
    • Reduced Inflammation

    • Low evidence

  • Modulatory effects of l-carnitine plus l-acetyl-carnitine on neuroendocrine control of hypothalamic functions in functional hypothalamic amenorrhea (FHA).

    • 2017-06-02
    • Clinical Trial · n = 27
    • Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 33(12)
    • • Alessandro D Genazzani
      • Giulia Despini
      • Adam Czyzyk
      • Agnieszka Podfigurna
      • Tommaso Simoncini
      • Blazej Meczekalski

    • PubMed: 28573875
    • DOI: 10.1080/09513590.2017.1332587

    4 Insights on

    • Reduced Cortisol Levels
    • Increased LH Level
    • Reduced Amylase Level
    • Increased 17OHP/Cortisol Ratio

    • Moderate evidence
• June 6

  • Irritable bowel syndrome symptom severity improves equally with probiotic and placebo

    • 2017-06-06
    • RCT · n = 340
    • World Journal of Gastroenterology 22(48)
    • • Anna Lyra
      • M. Hillilä
      • T. Huttunen
      • Sofia Männikkö
      • M. Taalikka
      • Julia Tennilä
      • A. Tarpila
      • S. Lahtinen
      • A. Ouwehand
      • L. Veijola

    • PubMed: 28082816
    • DOI: 10.3748/wjg.v22.i48.10631

    3 Insights on

    • Reduced Abdominal Pain Severity
    • Reduced Abdominal Pain
    • Improved Irritable Bowel Syndrome Symptom Severity

    • High evidence
    • Large Human Trial
    • Highly Cited
    • Rigorous Journal
• June 8

  • Effect of probiotic Lactobacillus on lipid profile: A systematic review and meta-analysis of randomized, controlled trials

    • 2017-06-08
    • Meta-Analysis
    • PLOS ONE 12(6)
    • • Yucheng Wu
      • Qingqing Zhang
      • Yin Ren
      • Z. Ruan

    • PubMed: 28594860
    • DOI: 10.1371/journal.pone.0178868

    9 Insights on

    • Reduced Total Cholesterol Levels
    • Reduced Low-Density Lipoprotein Level
    • Reduced Triglyceride Levels
    • Increased HDL Cholesterol Levels
    • Reduced LDL Cholesterol
    • Reduced Serum Total Cholesterol Levels
    • Improved Triglyceride Levels
    • Reduced Total Cholesterol
    • Increased High-Density Lipoprotein Cholesterol

    • High evidence
    • Highly Cited
    • Rigorous Journal

  • A synbiotic composed of Lactobacillus fermentum CECT5716 and FOS prevents the development of fatty acid liver and glycemic alterations in rats fed a high fructose diet associated with changes in the microbiota.

    • 2017-06-08
    • Clinical Trial
    • Molecular Nutrition & Food Research 61(8)
    • • Belén Rivero-Gutiérrez
      • Reyes Gámez-Belmonte
      • M. D. Suárez
      • J. Lavín
      • A. Aransay
      • M. Olivares
      • O. Martínez-Augustin
      • F. Sánchez de Medina
      • A. Zarzuelo

    • PubMed: 28463404
    • DOI: 10.1002/mnfr.201600622

    7 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Hepatic Steatosis
    • Reduced Inflammation
    • Prevention of Liver Steatosis
    • Improved Gut Barrier Function
    • Improved Blood Lipid Profile
    • Improved Glycemia

    • Low evidence
    • Animal Study

  • Inorganic salts and intracellular polyphosphate inclusions play a role in the thermotolerance of the immunobiotic Lactobacillus rhamnosus CRL 1505

    • 2017-06-08
    • PLOS ONE 12(6)
    • • M. A. Correa Deza
      • M. Grillo-Puertas
      • S. Salva
      • V. Rapisarda
      • C. L. Gerez
      • G. Font de Valdez

    • PubMed: 28594955
    • DOI: 10.1371/journal.pone.0179242

    1 Insight on

    • Improved Thermotolerance

    • Low evidence
    • Rigorous Journal
• June 12

  • Live Probiotic Lactobacillus johnsonii BS15 Promotes Growth Performance and Lowers Fat Deposition by Improving Lipid Metabolism, Intestinal Development, and Gut Microflora in Broilers

    • 2017-06-12
    • RCT · n = 180
    • Frontiers in Microbiology 8
    • • Hesong Wang
      • Xueqin Ni
      • Xiaodan Qing
      • Dong Zeng
      • Min Luo
      • Lei Liu
      • Guangyao Li
      • Kangcheng Pan
      • Bo Jing

    • PubMed: 28659893
    • DOI: 10.3389/fmicb.2017.01073

    9 Insights on

    • Improved Gut Microbiota
    • Improved Gut Microbiota Composition
    • Improved Lipid Metabolism
    • Improved Growth Performance
    • Enhanced Digestive Enzyme Activity
    • Reduced Fat Deposition
    • Improved Intestinal Development
    • Reduced Fat Accumulation
    • Improved Digestive Function

    • Low evidence
    • Highly Cited
    • Animal Study

  • Lactobacillus johnsonii N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults

    • 2017-06-12
    • RCT · n = 42
    • Frontiers in Immunology 8
    • • G. Marcial
      • A. Ford
      • M. Haller
      • S. Gezan
      • N. Harrison
      • D. Cai
      • Julie L. Meyer
      • D. Perry
      • M. Atkinson
      • C. Wasserfall
      • T. Garrett
      • Claudio F. Gonzalez
      • T. Brusko
      • W. Dahl
      • G. Lorca

    • PubMed: 28659913
    • DOI: 10.3389/fimmu.2017.00655

    2 Insights on

    • Reduced Kynurenine-Tryptophan Ratio
    • Elevated Serum Tryptophan Levels

    • High evidence
• June 13

  • High γ-aminobutyric acid production from lactic acid bacteria: Emphasis on Lactobacillus brevis as a functional dairy starter

    • 2017-06-13
    • Critical Reviews in Food Science and Nutrition 57(17)
    • • Qinglong Wu
      • N. Shah

    • PubMed: 26980301
    • DOI: 10.1080/10408398.2016.1147418

    3 Insights on

    • Reduced Blood Pressure
    • Reduced Depression Symptoms
    • Reduced Hypertension

    • Low evidence
    • Highly Cited

  • Phylogenomics and comparative genomics of Lactobacillus salivarius, a mammalian gut commensal

    • 2017-06-13
    • Microbial Genomics 3(8)
    • • H. Harris
      • M. Bourin
      • M. Claesson
      • P. O’Toole

    • PubMed: 29026656
    • DOI: 10.1099/mgen.0.000115

    2 Insights on

    • Reduced Straining
    • Potential Probiotic Health Effects

    • Low evidence
    • Rigorous Journal
• June 21

  • Preventive Effect of Lactobacillus helveticus SBT2171 on Collagen-Induced Arthritis in Mice

    • 2017-06-21
    • Clinical Trial
    • Frontiers in Microbiology 8
    • • M. Yamashita
      • K. Matsumoto
      • T. Endo
      • K. Ukibe
      • T. Hosoya
      • Y. Matsubara
      • H. Nakagawa
      • F. Sakai
      • T. Miyazaki

    • PubMed: 28680422
    • DOI: 10.3389/fmicb.2017.01159

    10 Insights on

    • Reduced Interleukin-6 Levels
    • Reduced Body Weight
    • Reduced Joint Swelling
    • Reduced Serum Level of CII-specific Antibodies
    • Reduced Arthritis Incidence
    • Reduced Joint Damage
    • Reduced Total Immune Cells in Draining Lymph Nodes
    • Reduced B Cell Count in Draining Lymph Nodes
    • Reduced Germinal Center B Cells in Draining Lymph Nodes
    • Reduced CD4+ T Cell Count in Draining Lymph Nodes

    • Low evidence
    • Animal Study
• June 28

  • Combination of Metabolomic and Proteomic Analysis Revealed Different Features among Lactobacillus delbrueckii Subspecies bulgaricus and lactis Strains While In Vivo Testing in the Model Organism Caenorhabditis elegans Highlighted Probiotic Properties

    • 2017-06-28
    • Frontiers in Microbiology 8
    • • E. Zanni
      • Emily Schifano
      • S. Motta
      • F. Sciubba
      • C. Palleschi
      • P. Mauri
      • G. Perozzi
      • D. Uccelletti
      • C. Devirgiliis
      • A. Miccheli

    • PubMed: 28702021
    • DOI: 10.3389/fmicb.2017.01206

    9 Insights on

    • Increased Lifespan
    • Enhanced Larval Development in Caenorhabditis elegans
    • Extended Lifespan
    • Improved Cognitive Development
    • Improved Lifespan
    • Extended Lifespan in Caenorhabditis elegans
    • Enhanced Larval Development
    • Reduced Lifespan
    • Impaired Larval Development

    • Low evidence
• June 29

  • Effects of the probiotic Bifidobacterium animalis subsp. lactis on the non-surgical treatment of periodontitis. A histomorphometric, microtomographic and immunohistochemical study in rats

    • 2017-06-29
    • RCT · n = 32
    • PLOS ONE 12(6)
    • • M. S. Ricoldi
      • F. Furlaneto
      • L. Oliveira
      • G. C. Teixeira
      • Jéssica P Pischiotini
      • A. L. Moreira
      • E. Ervolino
      • M. N. de Oliveira
      • C. Bogsan
      • S. Salvador
      • M. Messora

    • PubMed: 28662142
    • DOI: 10.1371/journal.pone.0179946

    7 Insights on

    • Increased Anti-Inflammatory Cytokine Levels
    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Alveolar Bone Resorption
    • Reduced Attachment Loss
    • Reduced Osteoclast Number
    • Improved Aerobic to Anaerobic Bacteria Ratio
    • Reduced Osteoclast Activity

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Effects of Bifidobacterium animalis subsp. lactis BB-12® on the lipid/lipoprotein profile and short chain fatty acids in healthy young adults: a randomized controlled trial

    • 2017-06-29
    • RCT · n = 30
    • Nutrition Journal 16(1)
    • • Yujin Lee
      • Zhaoyong Ba
      • R. Roberts
      • C. Rogers
      • J. Fleming
      • Huicui Meng
      • E. Furumoto
      • P. Kris-Etherton

    • PubMed: 28662676
    • DOI: 10.1186/s12937-017-0261-6

    8 Insights on

    • Reduced Low-Density Lipoprotein Level
    • Increased Acetic Acid Levels in Feces
    • Improved Lipid Profile
    • No Change in Lipid Profile
    • Increased Fecal Acetate Levels
    • Reduced Fecal Acetate
    • Improved Blood Lipid Profile
    • Improved Fecal Short-Chain Fatty Acid Levels

    • High evidence
• Undated – 7 supplement studies

  • Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection: A Systematic Review With Meta-Regression Analysis.

    • 2017-06
    • Meta-Analysis
    • Gastroenterology 152(8)
    • • Nicole T. Shen
      • A. Maw
      • L. Tmanova
      • A. Pino
      • K. Ancy
      • C. Crawford
      • M. Simon
      • A. Evans

    • PubMed: 28192108
    • DOI: 10.1053/j.gastro.2017.02.003

    2 Insights on

    • Increased Adverse Events
    • Reduced Clostridium difficile Infection

    • High evidence
    • Highly Cited

  • Extensively hydrolyzed casein formula containing Lactobacillus rhamnosus GG reduces the occurrence of other allergic manifestations in children with cow's milk allergy: 3‐year randomized controlled trial

    • 2017-06
    • RCT · n = 220
    • Journal of Allergy and Clinical Immunology 139(6)
    • • R. B. Canani
      • M. Di Costanzo
      • G. Bedogni
      • Antonio Amoroso
      • L. Cosenza
      • C. di Scala
      • V. Granata
      • R. Nocerino

    • PubMed: 28043872
    • DOI: 10.1016/j.jaci.2016.10.050

    6 Insights on

    • Reduced Incidence of Allergic Manifestations
    • Accelerated Oral Tolerance Development
    • Improved Cow's Milk Tolerance
    • Enhanced Tolerance Acquisition
    • Improved Oral Tolerance
    • Improved Tolerance

    • High evidence
    • Highly Cited

  • Kefir alleviates obesity and hepatic steatosis in high-fat diet-fed mice by modulation of gut microbiota and mycobiota: targeted and untargeted community analysis with correlation of biomarkers.

    • 2017-06
    • RCT
    • The Journal of Nutritional Biochemistry 44
    • • Dong‐Hyeon Kim
      • Hyunsook Kim
      • Dana Jeong
      • Il‐Byeong Kang
      • Jung-Whan Chon
      • Hong-Seok Kim
      • K. Song
      • K. Seo

    • PubMed: 28384519
    • DOI: 10.1016/j.jnutbio.2017.02.014

    8 Insights on

    • Reduced Interleukin-6 Levels
    • Reduced Body Weight
    • Reduced Liver Lesion Severity
    • Increased Fatty Acid Oxidation
    • Increased Gut Levels of Lactobacillus and Lactococcus
    • Elevated Gut Yeast Levels
    • Reduced Histological Liver Injury
    • Reduced IL-6 Concentration

    • Low evidence
    • Highly Cited
    • Animal Study

  • Effect of dietary Clostridium butyricum on growth, intestine health status and resistance to ammonia stress in Pacific white shrimp Litopenaeus vannamei

    • 2017-06
    • Fish & Shellfish Immunology 65
    • • Yafei Duan
      • Yue Zhang
      • Hong-biao Dong
      • Yun Wang
      • Xiaoting Zheng
      • Jiasong Zhang

    • PubMed: 28359948
    • DOI: 10.1016/j.fsi.2017.03.048

    4 Insights on

    • Improved Gastrointestinal Health
    • Improved Growth Performance
    • Improved Resistance to Ammonia Nitrogen Stress
    • Increased Body Protein Content

    • Low evidence
    • Highly Cited

  • Adsorption of aflatoxin B1, zearalenone and ochratoxin A by microorganisms isolated from Kefir grains.

    • 2017-06
    • International Journal of Food Microbiology 251
    • • F. B. Taheur
      • Kais Fedhila
      • K. Chaieb
      • Bochra Kouidhi
      • A. Bakhrouf
      • L. Abrunhosa

    • PubMed: 28376398
    • DOI: 10.1016/j.ijfoodmicro.2017.03.021

    2 Insights on

    • Reduced Cytotoxic Effects
    • Reduced Gastrointestinal Absorption of Mycotoxins

    • Low evidence
    • Highly Cited

  • Study of Bacillus subtilis on growth performance, nutrition metabolism and intestinal microflora of 1 to 42 d broiler chickens

    • 2017-06
    • RCT · n = 800
    • Animal Nutrition 3(2)
    • • Zhenhua Gao
      • Haohao Wu
      • Lin Shi
      • Xiaohui Zhang
      • R. Sheng
      • Fuquan Yin
      • R. Gooneratne

    • PubMed: 29767043
    • DOI: 10.1016/j.aninu.2017.02.002

    9 Insights on

    • Improved Average Daily Gain
    • Improved Growth Performance
    • Reduced Harmful Gut Bacteria
    • Enhanced Metabolism of Organic Matter
    • Reduced Harmful Intestinal Bacteria
    • Reduced Harmful Bacterial Populations
    • Improved Nutrient Metabolism
    • Improved Nutritional Metabolism
    • Improved Metabolism

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Factors influencing ruminal bacterial community diversity and composition and microbial fibrolytic enzyme abundance in lactating dairy cows with a focus on the role of active dry yeast.

    • 2017-06
    • RCT
    • Journal of Dairy Science 100(6)
    • • O. Alzahal
      • Fuyong Li
      • L. Guan
      • N. Walker
      • B. McBride

    • PubMed: 28390722
    • DOI: 10.3168/jds.2016-11473

    1 Insight on

    • Increased Abundance of Microbial Fibrolytic Enzymes

    • High evidence
    • Rigorous Journal