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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Effects of tree nut and groundnut consumption compared with those of l-arginine supplementation on fasting and postprandial flow-mediated vasodilation: Meta-analysis of human randomized controlled trials.
- 2021-04
- Meta-Analysis
- Clinical nutrition (Edinburgh, Scotland) 40(4)
- - Ellen T H C Smeets
  - Ronald P Mensink
  - Peter J Joris
- PubMed: 32980186
- DOI: 10.1016/j.clnu.2020.09.015
1 Insight on
- Improved Flow-Mediated Vasodilation
- High evidence
Lack of effect of Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12 on beta-cell function in children with newly diagnosed type 1 diabetes: a randomised controlled trial
- 2021-03
- RCT · n = 96
- BMJ Open Diabetes Research & Care 9(1)
- - Lidia Groele
  - H. Szajewska
  - M. Szalecki
  - J. Świderska
  - M. Wysocka-Mincewicz
  - Agnieszka Ochocińska
  - A. Stelmaszczyk-Emmel
  - U. Demkow
  - A. Szypowska
- PubMed: 33771763
- DOI: 10.1136/bmjdrc-2020-001523
2 Insights on
- Preserved Pancreatic Beta-Cell Function
- Increased Thyroid Autoimmunity
- High evidence
- Rigorous Journal
Physicochemical Analysis of Yogurt Produced by Leuconostoc mesenteroides H40 and Its Effects on Oxidative Stress in Neuronal Cells
- 2021-03
- Food Science of Animal Resources 41(2)
- - N. Lee
  - Sung-Min Lim
  - Min-Jeong Cheon
  - H. Paik
- PubMed: 33987547
- DOI: 10.5851/kosfa.2020.e97
3 Insights on
- Low evidence
Streptococcus thermophilus inhibits colorectal tumorigenesis through secreting β-galactosidase.
- 2021-03
- Clinical Trial
- Gastroenterology 160(4)
- - Qing Li
  - Wei Hu
  - Weixin Liu
  - Liuyang Zhao
  - Dan Huang
  - Xiao-Dong Liu
  - H. Chan
  - Yuchen Zhang
  - Ju-deng Zeng
  - O. Coker
  - W. Kang
  - S. Ng
  - Lin Zhang
  - S. Wong
  - T. Gin
  - M. Chan
  - Jian-Lin Wu
  - Jun Yu
  - W. Wu
- PubMed: 32920015
- DOI: 10.1053/J.GASTRO.2020.09.003
9 Insights on
- Low evidence
- Highly Cited
- Animal Study
The influence of soy protein hydrolysate (SPH) addition to infant formula powder on Streptococcus thermophilus proliferation and metabolism.
- 2021-03
- Food Research International 141
- - Zhirui Sun
  - Mingyong Yao
  - Xin Bian
  - Q. Guo
  - Huanan Guan
  - Yang Yang
  - B. Wang
  - Yanguo Shi
  - W. Piekoszewski
  - Xiao-Wan Yang
  - N. Zhang
- PubMed: 33641970
- DOI: 10.1016/j.foodres.2020.110103
2 Insights on
- Enhanced Probiotic Growth
- Increased Antibacterial Compound Production
- Low evidence
Effects of artichoke on blood pressure: A systematic review and meta-analysis.
- 2021-03
- Meta-Analysis
- Complementary therapies in medicine 57
- - Mozhgan Moradi
  - Ghazale Sohrabi
  - Mojgan Golbidi
  - Samira Yarmohammadi
  - Niloofar Hemati
  - Marilyn S Campbell
  - Sajjad Moradi
  - Mohammad Ali Hojjati Kermani
  - Mohammad Hosein Farzaei
- PubMed: 33465383
- DOI: 10.1016/j.ctim.2021.102668
2 Insights on
- Reduced Diastolic Blood Pressure
- Reduced Systolic Blood Pressure
- High evidence
Evaluation of in vitro and in vivo potential of Bacillus subtilis MBTDCMFRI Ba37 as a candidate probiont in fish health management.
- 2021-03
- Clinical Trial
- Microbial Pathogenesis 152
- - Anusree V. Nair
  - M. Leo Antony
  - N. K. Praveen
  - P. Sayooj
  - T. Raja Swaminathan
  - K. K. Vijayan
- PubMed: 33212198
- DOI: 10.1016/j.micpath.2020.104610
13 Insights on
- Low evidence
- Animal Study
Dietary supplementation with Bacillus subtilis promotes growth performance of broilers by altering the dominant microbial community
- 2021-03
- RCT · n = 270
- Poultry Science 100(3)
- - Shan Zhang
  - Guang Zhong
  - D. Shao
  - Qiang Wang
  - Yan Hu
  - Tian-xing Wu
  - Chaojin Ji
  - Shourong Shi
- PubMed: 33652528
- DOI: 10.1016/j.psj.2020.12.032
6 Insights on
- Low evidence
- Highly Cited
- Rigorous Journal
- Animal Study
Bacillus amyloliquefaciens CECT 5940 improves performance and gut function in broilers fed different levels of protein and/or under necrotic enteritis challenge
- 2021-03
- Animal Nutrition 7(1)
- - K. Gharib-Naseri
  - J. Dorigam
  - K. Doranalli
  - N. Morgan
  - R. Swick
  - M. Choct
  - Shu‐Biao Wu
- PubMed: 33997347
- DOI: 10.1016/j.aninu.2020.05.004
4 Insights on
- Low evidence
- Rigorous Journal
Physiological Characteristics and Anti-Diabetic Effect of Pediococcus pentosaceus KI62
- 2021-03
- Food Science of Animal Resources 41(2)
- - Seulki Kim
  - Sangpil Hong
  - Sang-Dong Lim
- PubMed: 33987548
- DOI: 10.5851/kosfa.2020.e99
3 Insights on
- Low evidence
Impact of manipulation of glycerol/diol dehydratase activity on intestinal microbiota ecology and metabolism.
- 2021-03
- Environmental Microbiology 23(3)
- - Alejandro Ramirez Garcia
  - Jianbo Zhang
  - A. Greppi
  - F. Constancias
  - Esther Wortmann
  - Muriel Wandres
  - K. Hurley
  - A. Pascual-García
  - Hans-Joachim Ruscheweyh
  - S. Sturla
  - C. Lacroix
  - C. Schwab
- PubMed: 33587772
- DOI: 10.1111/1462-2920.15431
2 Insights on
- Reduced Fermentation Time
- Enhanced Carcinogenic Heterocyclic Amine Transformation
- Low evidence
Effects of exogenous probiotics on the gut microbiota and clinical outcomes in critically ill patients: a randomized controlled trial.
- 2021-02
- RCT · n = 61
- Annals of Palliative Medicine 10(2)
- - Jie Wang
  - Hui Ke
  - Kai-Xiong Liu
  - J. Qu
- PubMed: 33040557
- DOI: 10.21037/apm-20-202
2 Insights on
- Reduced Fever Duration
- Reduced Incidence of Constipation
- High evidence
Bacillus coagulans 13002 and fructo-oligosaccharides improve the immunity of mice with immunosuppression induced by cyclophosphamide through modulating intestinal-derived and fecal microbiota.
- 2021-02
- Clinical Trial
- Food Research International 140
- - Shan Zhao
  - Xin Peng
  - Qin‐yu Zhou
  - Yan‐yan Huang
  - Xiang Rao
  - Jia-Lin Tu
  - Hong-Yi Xiao
  - Dong‐mei Liu
- PubMed: 33648160
- DOI: 10.1016/j.foodres.2020.109793
9 Insights on
- Low evidence
- Animal Study
Bacillus subtilis-fermented products ameliorate the growth performance and alter cecal microbiota community in broilers under lipopolysaccharide challenge.
- 2021-02
- RCT
- Poultry Science 100(2)
- - Jiun-Yu Chen
  - Yu-Hsiang Yu
- PubMed: 33518141
- DOI: 10.1016/j.psj.2020.10.070
5 Insights on
- High evidence
- Rigorous Journal
Quantification and gene expression of Lactobacillus casei group species associated with dentinal lesions in early childhood caries
- 2021-02
- Observational · n = 38
- The Saudi Dental Journal 33(2)
- - A. C. A. Reis
  - D. S. Bezerra
  - Erika Nikitza Shiauha Hart-Chú
  - R. N. Stipp
  - S. Guedes
  - B. G. Neves
  - L. K. Rodrigues
- PubMed: 33551619
- DOI: 10.1016/j.sdentj.2020.01.006
1 Insight on
- Increased Expression of wzb Gene in Active Dentinal Caries
- High evidence
- Rigorous Journal
Efficacy of a partially hydrolysed formula, with reduced lactose content and with Lactobacillus reuteri DSM 17938 in infant colic: A double blind, randomised clinical trial.
- 2021-02
- RCT
- Clinical Nutrition 40(2)
- - R. Turco
  - M. Russo
  - D. Bruzzese
  - A. Staiano
- PubMed: 32600858
- DOI: 10.1016/j.clnu.2020.05.048
1 Insight on
- Reduced Crying Duration
- High evidence
[Treatment of IBS with Lactobacillus plantarum 299v: Therapeutic success increases with length of treatment - real-life data of a non-interventional study in Germany].
- 2021-02
- Observational · n = 221
- Zeitschrift fur Gastroenterologie 59(02)
- - Heiner Krammer
  - Martin Storr
  - Ahmed Madisch
  - Julia Riffel
- PubMed: 33556972
- DOI: 10.1055/a-1340-0204
20 Insights on
- High evidence
Lactobacillus reuteri DSM 17938 alleviates d-galactosamine-induced liver failure in rats.
- 2021-01
- Clinical Trial
- Biomedicine & Pharmacotherapy 133
- - Huiyong Jiang
  - Ren Yan
  - Kaicen Wang
  - Qiangqiang Wang
  - Xiaoxiao Chen
  - Lifeng Chen
  - Lanjuan Li
  - L. Lv
- PubMed: 33202285
- DOI: 10.1016/j.biopha.2020.111000
7 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Fewer Community-Acquired Colds with Daily Consumption of Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2. A Randomized, Placebo-Controlled Clinical Trial
- 2021-01
- RCT · n = 898
- The Journal of Nutrition 151(1)
- - I. L. Ahrén
  - M. Hillman
  - E. Nordström
  - N. Larsson
  - T. Niskanen
- PubMed: 33296464
- DOI: 10.1093/jn/nxaa353
11 Insights on
- High evidence
- Large Human Trial
Effect of long-term dietary probiotic Lactobacillus reuteri 1 or antibiotics on meat quality, muscular amino acids and fatty acids in pigs.
- 2021-01
- Clinical Trial
- Meat Science 171
- - Z. Tian
  - Yiyan Cui
  - Huijie Lu
  - Gang Wang
  - Xianyong Ma
- PubMed: 32906013
- DOI: 10.1016/j.meatsci.2020.108234
3 Insights on
- Low evidence
- Animal Study
Efficacy of L-Carnitine for Dilated Cardiomyopathy: A Meta-Analysis of Randomized Controlled Trials.
- 2021-01
- Meta-Analysis · n = 23
- BioMed research international 2021(1)
- - Yayun Weng
  - Shuo Zhang
  - Wei Huang
  - Xianze Xie
  - Zhiyuan Ma
  - Qiaomei Fan
- PubMed: 33521132
- DOI: 10.1155/2021/9491615
6 Insights on
- High evidence
Effect of feeding Bacillus subtilis on rumen fermentation, blood metabolites, nutrient digestibility, and energy and nitrogen balances in non-lactating crossbred cows.
- 2021-01
- RCT · n = 4
- Animal Science Journal 92(1)
- - Daisuke Kawauchi
  - W. Angthong
  - O. Keaokliang
  - T. Ishida
  - Toshihiro Takahashi
  - T. Kawashima
- PubMed: 33638258
- DOI: 10.1111/asj.13531
2 Insights on
- Reduced Plasma Non-Esterified Fatty Acid Concentrations
- Increased Heat Production
- Low evidence
- Animal Study
Bifidobacterium longum counters the effects of obesity: Partial successful translation from rodent to human
- 2021-01
- RCT
- EBioMedicine 63
- - H. Schellekens
  - C. Torres-Fuentes
  - M. van de Wouw
  - C. Long-Smith
  - A. Mitchell
  - C. Strain
  - K. Berding
  - T. Bastiaanssen
  - K. Rea
  - A. Golubeva
  - S. Arboleya
  - Mathieu Verpaalen
  - M. Pusceddu
  - A. Murphy
  - F. Fouhy
  - K. Murphy
  - P. Ross
  - Bernard L. Roy
  - C. Stanton
  - T. Dinan
  - J. Cryan
- PubMed: 33349590
- DOI: 10.1016/j.ebiom.2020.103176
13 Insights on
- High evidence
- Rigorous Journal
The Possible Role of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson's Disease.
- 2021-01
- Oxidative medicine and cellular longevity 2021(1)
- - Ovidiu-Dumitru Ilie
  - Emanuela Paduraru
  - Madalina-Andreea Robea
  - Ioana-Miruna Balmus
  - Roxana Jijie
  - Mircea Nicoara
  - Alin Ciobica
  - Ilinca-Bianca Nita
  - Romeo Dobrin
  - Bogdan Doroftei
- PubMed: 34691361
- DOI: 10.1155/2021/9629102
3 Insights on
- Low evidence
Potential mechanisms underlying the ameliorative effect of Lactobacillus paracasei FZU103 on the lipid metabolism in hyperlipidemic mice fed a high-fat diet.
- 2021-01
- Clinical Trial
- Food Research International 139
- - Xu-Cong Lv
  - Min Chen
  - Zi-Rui Huang
  - Wei-ling Guo
  - Lian-zhong Ai
  - Weidong Bai
  - Xiao-Dan Yu
  - Ying-Li Liu
  - P. Rao
  - Li Ni
- PubMed: 33509508
- DOI: 10.1016/j.foodres.2020.109956
10 Insights on
- Low evidence
- Animal Study
Probiotic-Derived Polyphosphate Accelerates Intestinal Epithelia Wound Healing through Inducing Platelet-Derived Mediators.
- 2021-01
- Mediators of inflammation 2021(1)
- - Shotaro Isozaki
  - Hiroaki Konishi
  - Mikihiro Fujiya
  - Hiroki Tanaka
  - Yuki Murakami
  - Shin Kashima
  - Katsuyoshi Ando
  - Nobuhiro Ueno
  - Kentaro Moriichi
  - Toshikatsu Okumura
- PubMed: 33859537
- DOI: 10.1155/2021/5582943
3 Insights on
- Low evidence
- Animal Study
Effect of active dry yeast on lactation performance, methane production, and ruminal fermentation patterns in early-lactating Holstein cows.
- 2021-01
- RCT · n = 60
- Journal of Dairy Science 104(1)
- - Yan Li
  - Yizhao Shen
  - J. Niu
  - Yanfei Guo
  - Mirielle L Pauline
  - Xiaojing Zhao
  - Qiufeng Li
  - Yufeng Cao
  - Chongliang Bi
  - Xiujiang Zhang
  - Zhonghua Wang
  - Yanxia Gao
  - Jianguo Li
- PubMed: 33272580
- DOI: 10.3168/jds.2020-18594
4 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Immuno-modulation by heat-killed Lacticaseibacillus paracasei MCC1849 and its application to food products
- 2021-01
- International Journal of Immunopathology and Pharmacology 35
- - Hazuki Maehata
  - S. Arai
  - N. Iwabuchi
  - F. Abe
- PubMed: 33787390
- DOI: 10.1177/20587384211008291
1 Insight on
- Modulated Immune Response
- Low evidence
- Rigorous Journal
Rice flour fermented with Lactobacillus paracasei CBA L74 in the treatment of atopic dermatitis in infants: A randomized, double- blind, placebo- controlled trial.
- 2021-01
- RCT
- Pharmacological Research 163
- - E. D’Auria
  - S. Panelli
  - L. Lunardon
  - M. Pajoro
  - L. Paradiso
  - S. Beretta
  - C. Loretelli
  - D. Tosi
  - Matteo Perini
  - G. Bedogni
  - A. Abdelsalam
  - P. Fiorina
  - C. Bandi
  - G. Zuccotti
- PubMed: 33157233
- DOI: 10.1016/j.phrs.2020.105284
13 Insights on
- High evidence
- Rigorous Journal
Effect of supplementation of a dairy-originated probiotic bacterium, Propionibacterium freudenreichii subsp. freudenreichii, on the cecal microbiome of turkeys challenged with multidrug-resistant Salmonella Heidelberg1
- 2021-01
- RCT
- Poultry Science 100(1)
- - Divek V. T. Nair
  - T. Johnson
  - S. Noll
  - A. Kollanoor Johny
- PubMed: 33357692
- DOI: 10.1016/j.psj.2020.09.091
2 Insights on
- Reduced Inflammatory Response
- Reduced Multidrug-Resistant Salmonella Heidelberg Colonization
- High evidence
- Rigorous Journal