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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Effect of Chocolate and Yerba Mate Phenolic Compounds on Inflammatory and Oxidative Biomarkers in HIV/AIDS Individuals.
- 2016-05-23
- RCT · n = 92
- Nutrients 8(5)
- - Aline A Petrilli
  - Suelen J Souza
  - Andrea M Teixeira
  - Patricia M Pontilho
  - José M P Souza
  - Liania A Luzia
  - Patricia H C Rondó
- PubMed: 27223302
- DOI: 10.3390/nu8050132
1 Insight on
- Increased High-Density Lipoprotein Cholesterol
- High evidence
- Rigorous Journal
Effect of Bifidobacterium upon Clostridium difficile Growth and Toxicity When Co-cultured in Different Prebiotic Substrates
- 2016-05-18
- Frontiers in Microbiology 7
- - Lorena Valdés-Varela
  - A. Hernández-Barranco
  - P. Ruas-Madiedo
  - M. Gueimonde
- PubMed: 27242753
- DOI: 10.3389/fmicb.2016.00738
2 Insights on
- Reduced Toxicity
- Reduced Clostridium Difficile Growth
- Low evidence
Phytotherapy for Benign Prostatic Hyperplasia.
- 2016-05-14
- Review
- Current urology reports 17(7)
- - Aryeh Keehn
  - Jacob Taylor
  - Franklin C Lowe
- PubMed: 27180172
- DOI: 10.1007/s11934-016-0609-z
1 Insight on
- Improved Lower Urinary Tract Symptoms
- Low evidence
Effectiveness of Lactobacillus helveticus and Lactobacillus rhamnosus for the management of antibiotic-associated diarrhoea in healthy adults: a randomised, double-blind, placebo-controlled trial
- 2016-05-12
- RCT · n = 120
- British Journal of Nutrition 116(1)
- - M. Evans
  - Ryan P Salewski
  - M. Christman
  - S. Girard
  - T. Tompkins
- PubMed: 27169634
- DOI: 10.1017/S0007114516001665
1 Insight on
- Reduced Duration of Diarrhea
- High evidence
Characterization of Pediococcus acidilactici strains isolated from rainbow trout (Oncorhynchus mykiss) feed and larvae: safety, DNA fingerprinting, and bacteriocinogenicity.
- 2016-05-03
- Diseases of Aquatic Organisms 119(2)
- - Carlos Araújo
  - E. Muñoz-Atienza
  - P. Poeta
  - G. Igrejas
  - P. Hernández
  - C. Herranz
  - L. Cintas
- PubMed: 27137071
- DOI: 10.3354/dao02992
3 Insights on
- Low evidence
Lactobacillus rhamnosus GG Intake Modifies Preschool Children’s Intestinal Microbiota, Alleviates Penicillin-Associated Changes, and Reduces Antibiotic Use
- 2016-04-25
- RCT · n = 319
- PLOS ONE 11(4)
- - K. Korpela
  - A. Salonen
  - L. Virta
  - M. Kumpu
  - R. Kekkonen
  - W. D. de Vos
- PubMed: 27111772
- DOI: 10.1371/journal.pone.0154012
2 Insights on
- Reduced Antibiotic-Associated Gastrointestinal Complaints
- Reduced Antibiotic Use
- High evidence
- Large Human Trial
- Rigorous Journal
A combination of scGOS/lcFOS with Bifidobacterium breve M-16V protects suckling rats from rotavirus gastroenteritis
- 2016-04-25
- Clinical Trial
- European Journal of Nutrition 56(4)
- - M. Rigo-Adrover
  - M. Rigo-Adrover
  - S. Saldaña-Ruíz
  - S. Saldaña-Ruíz
  - K. Limpt
  - K. Knipping
  - J. Garssen
  - J. Knol
  - À. Franch
  - À. Franch
  - M. Castell
  - M. Castell
  - F. Pérez-Cano
  - F. Pérez-Cano
- PubMed: 27112962
- DOI: 10.1007/s00394-016-1213-1
2 Insights on
- Reduced Incidence of Severe Diarrhoea
- Improved Specific Antibody Response
- Low evidence
- Rigorous Journal
- Animal Study
Lactobacillus reuteri supplements do not affect salivary IgA or cytokine levels in healthy subjects: A randomized, double-blind, placebo-controlled, cross-over trial
- 2016-04-22
- RCT · n = 47
- Acta Odontologica Scandinavica 74(5)
- - M. Jørgensen
  - M. Keller
  - C. Kragelund
  - K. Hamberg
  - D. Ericson
  - C. Nielsen
  - S. Twetman
- PubMed: 27104984
- DOI: 10.3109/00016357.2016.1169439
2 Insights on
- Unchanged Salivary IgA Levels
- No Change in Salivary Cytokine Levels
- High evidence
Probiotic Strain Bifidobacterium animalis subsp. lactis CECT 8145 Reduces Fat Content and Modulates Lipid Metabolism and Antioxidant Response in Caenorhabditis elegans.
- 2016-04-19
- Clinical Trial
- Journal of Agricultural and Food Chemistry 64(17)
- - P. Martorell
  - S. Llopis
  - Núria González
  - E. Chenoll
  - Noemi López-Carreras
  - A. Aleixandre
  - Yang Chen
  - Edwuard D Karoly
  - D. Ramón
  - S. Genovés
- PubMed: 27054371
- DOI: 10.1021/acs.jafc.5b05934
9 Insights on
- Low evidence
- Animal Study
Differential proteome and cellular adhesion analyses of the probiotic bacterium Lactobacillus acidophilus NCFM grown on raffinose – an emerging prebiotic
- 2016-04-13
- PROTEOMICS 16(9)
- - Hasan Ufuk Celebioglu
  - M. Ejby
  - A. Majumder
  - Carsten Købler
  - Y. Goh
  - K. Thorsen
  - Bjarne Schmidt
  - Sarah O’Flaherty
  - M. Abou Hachem
  - S. Lahtinen
  - S. Jacobsen
  - T. Klaenhammer
  - S. Brix
  - K. Mølhave
  - B. Svensson
- PubMed: 26959526
- DOI: 10.1002/pmic.201500212
1 Insight on
- Increased Cellular Adhesion
- Low evidence
- Rigorous Journal
Effects of supplementing an active dry yeast product on rumen microbial community composition and on subsequent rumen fermentation of lactating cows in the mid-to-late lactation period.
- 2016-04-13
- Clinical Trial · n = 15
- Animal Science Journal 88(1)
- - Y. Uyeno
  - K. Akiyama
  - T. Hasunuma
  - H. Yamamoto
  - Hiroaki Yokokawa
  - T. Yamaguchi
  - K. Kawashima
  - M. Itoh
  - S. Kushibiki
  - M. Hirako
- PubMed: 27072297
- DOI: 10.1111/asj.12612
1 Insight on
- Reduced Acetate to Propionate Ratio
- Low evidence
- Animal Study
Does larch arabinogalactan enhance immune function? A review of mechanistic and clinical trials.
- 2016-04-12
- Review
- Nutrition & metabolism 13(1)
- - Carine Dion
  - Eric Chappuis
  - Christophe Ripoll
- PubMed: 27073407
- DOI: 10.1186/s12986-016-0086-x
5 Insights on
- Low evidence
Lactobacillus plantarum TWK10 Supplementation Improves Exercise Performance and Increases Muscle Mass in Mice
- 2016-04-07
- RCT · n = 18
- Nutrients 8(4)
- - Yi-Ming Chen
  - Li Wei
  - Yen-Shuo Chiu
  - Y. Hsu
  - Tsung-Yu Tsai
  - Ming-Fu Wang
  - Chi-Chang Huang
- PubMed: 27070637
- DOI: 10.3390/nu8040205
35 Insights on
- Low evidence
- Highly Cited
- Animal Study
Piperlongumine inhibits gastric cancer cells via suppression of the JAK1,2/STAT3 signaling pathway.
- 2016-04-05
- Molecular Medicine Reports 13(5)
- - Baoji Song
  - H. Zhan
  - Quan Bian
  - Junping Gu
- PubMed: 27053336
- DOI: 10.3892/mmr.2016.5091
1 Insight on
- Reduced Expression of STAT3-Dependent Tumor-Associated Genes
- Low evidence
- Rigorous Journal
Ganoderma lucidum (Reishi mushroom) for cancer treatment.
- 2016-04-05
- Meta-Analysis
- The Cochrane database of systematic reviews 2019(1)
- - Xingzhong Jin
  - Julieta Ruiz Beguerie
  - Daniel Man-Yeun Sze
  - Godfrey C F Chan
- PubMed: 27045603
- DOI: 10.1002/14651858.cd007731.pub3
8 Insights on
- High evidence
Triglyceride-Lowering Effects of Two Probiotics, Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601, in a Rat Model of High-Fat Diet-Induced Hypertriglyceridemia.
- 2016-03-28
- RCT · n = 3
- Journal of Microbiology and Biotechnology 26(3)
- - Il-dong Choi
  - Sung-Hwan Kim
  - Ji-Woong Jeong
  - Dong Eun Lee
  - C. Huh
  - S. Hong
  - J. Sim
  - Y. Ahn
- PubMed: 26699746
- DOI: 10.4014/jmb.1512.12018
4 Insights on
- Low evidence
- Animal Study
Post-sensitization administration of non-digestible oligosaccharides and Bifidobacterium breve M-16V reduces allergic symptoms in mice.
- 2016-03-24
- Immunity, Inflammation and Disease 4(2)
- - B. Van Esch
  - S. Abbring
  - M. Diks
  - G. Dingjan
  - L. Harthoorn
  - A. P. Vos
  - J. Garssen
- PubMed: 27933160
- DOI: 10.1002/iid3.101
6 Insights on
- Low evidence
Dietary supplements for dysmenorrhoea.
- 2016-03-22
- Meta-Analysis · n = 3,101
- The Cochrane database of systematic reviews 2016(3)
- - Porjai Pattanittum
  - Naowarat Kunyanone
  - Julie Brown
  - Ussanee S Sangkomkamhang
  - Joanne Barnes
  - Vahid Seyfoddin
  - Jane Marjoribanks
- PubMed: 27000311
- DOI: 10.1002/14651858.cd002124.pub2
1 Insight on
- Reduced Pain Intensity
- High evidence
Systematic review with meta-analysis: Lactobacillus reuteri DSM 17938 for diarrhoeal diseases in children.
- 2016-03-16
- Meta-Analysis · n = 1,229
- Alimentary pharmacology & therapeutics 43(10)
- - M Urbańska
  - D Gieruszczak-Białek
  - H Szajewska
- PubMed: 26991503
- DOI: 10.1111/apt.13590
2 Insights on
- Reduced Diarrhea Rate
- Increased Cure Rate
- High evidence
- Rigorous Journal
Potential protective effects of Clostridium butyricum on experimental gastric ulcers in mice.
- 2016-03-15
- RCT · n = 120
- World Journal of Gastroenterology 21(27)
- - Fang-yan Wang
  - Jiammin Liu
  - Hai-Hua Luo
  - Ai-hua Liu
  - Yong Jiang
- PubMed: 26217085
- DOI: 10.3748/wjg.v21.i27.8340
3 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Simple, fast, and accurate methodology for quantitative analysis using Fourier transform infrared spectroscopy, with bio-hybrid fuel cell examples.
- 2016-03-15
- MethodsX 3
- - David M Mackie
  - Justin P Jahnke
  - Marcus S Benyamin
  - James J Sumner
- PubMed: 26977411
- DOI: 10.1016/j.mex.2016.02.002
2 Insights on
- Improved Quantitative Analysis Methodology for FTIR Mixtures
- Improved Analytical Accuracy
- Low evidence
Regulatory effect of paraprobiotic Lactobacillus gasseri CP2305 on gut environment and function
- 2016-03-14
- RCT · n = 118
- Microbial Ecology in Health & Disease 27(0)
- - Tomonori Sugawara
  - D. Sawada
  - Y. Ishida
  - Kotaro Aihara
  - Yumeko Aoki
  - Isao Takehara
  - Kazuhiko Takano
  - S. Fujiwara
- PubMed: 26979643
- DOI: 10.3402/mehd.v27.30259
14 Insights on
- High evidence
- Rigorous Journal
Fermented milk containing Lactobacillus casei strain Shirota prevents the onset of physical symptoms in medical students under academic examination stress.
- 2016-03-11
- RCT · n = 47
- Beneficial Microbes 7(2)
- - Akito Kato-Kataoka
  - K. Nishida
  - M. Takada
  - K. Suda
  - M. Kawai
  - K. Shimizu
  - Akira Kushiro
  - R. Hoshi
  - O. Watanabe
  - Tomoki Igarashi
  - K. Miyazaki
  - Y. Kuwano
  - K. Rokutan
- PubMed: 26689231
- DOI: 10.3920/BM2015.0100
15 Insights on
- High evidence
- Highly Cited
Prophage-mediated modulation of interaction of Streptococcus thermophilus J34 with human intestinal epithelial cells and its competition against human pathogens.
- 2016-03-11
- Beneficial Microbes 7(2)
- - C. Guigas
  - K. Faulhaber
  - D. Duerbeck
  - H. Neve
  - K. Heller
- PubMed: 26689226
- DOI: 10.3920/BM2015.0108
1 Insight on
- Reduced Pathogen Adhesion
- Low evidence
Antiobesity effect of Pediococcus pentosaceus LP28 on overweight subjects: a randomized, double-blind, placebo-controlled clinical trial
- 2016-03-09
- RCT · n = 62
- European Journal of Clinical Nutrition 70(5)
- - Fumiko Higashikawa
  - M. Noda
  - Tomokazu Awaya
  - Narandalai Danshiitsoodol
  - Y. Matoba
  - T. Kumagai
  - Masanori Sugiyama
- PubMed: 26956126
- DOI: 10.1038/ejcn.2016.17
5 Insights on
- High evidence
- Highly Cited
Benefits of Bifidobacterium breve M-16V Supplementation in Preterm Neonates - A Retrospective Cohort Study
- 2016-03-08
- Meta-Analysis
- PLOS ONE 11(3)
- - S. Patole
  - Shripada C Rao
  - A. Keil
  - E. Nathan
  - D. Doherty
  - K. Simmer
- PubMed: 26953798
- DOI: 10.1371/journal.pone.0150775
4 Insights on
- High evidence
- Highly Cited
- Rigorous Journal
Lactobacillus reuteri Inhibition of Enteropathogenic Escherichia coli Adherence to Human Intestinal Epithelium
- 2016-03-01
- Frontiers in Microbiology 7
- - Alistair D. S. Walsham
  - D. Mackenzie
  - V. Cook
  - S. Wemyss-Holden
  - Claire L. Hews
  - N. Juge
  - S. Schüller
- PubMed: 26973622
- DOI: 10.3389/fmicb.2016.00244
2 Insights on
- Reduced Enteropathogenic Escherichia coli (EPEC) Adhesion
- Increased EPEC Microcolony Size
- Low evidence
Lactobacillus rhamnosus LA68 and Lactobacillus plantarum WCFS1 differently influence metabolic and immunological parameters in high fat diet-induced hypercholesterolemia and hepatic steatosis.
- 2016-03-01
- Clinical Trial
- Food & Function 6(2)
- - N. Ivanovic
  - R. Minić
  - L. Dimitrijević
  - Sanja Radojević Škodrić
  - I. Živković
  - B. Djordjevic
- PubMed: 25518825
- DOI: 10.1039/c4fo00843j
16 Insights on
- Low evidence
- Animal Study
The viability of Lactobacillus fermentum CECT5716 is not essential to exert intestinal anti-inflammatory properties.
- 2016-03-01
- Food & Function 6(4)
- - A. Rodríguez‐Nogales
  - F. Algieri
  - T. Vezza
  - N. Garrido-Mesa
  - M. Olivares
  - M. Comalada
  - C. Riccardi
  - M. P. Utrilla
  - M. Rodríguez-Cabezas
  - J. Gálvez
- PubMed: 25700085
- DOI: 10.1039/c4fo00938j
4 Insights on
- Low evidence
Evaluation of genetic and phenotypic consistency of Bacillus coagulans MTCC 5856: a commercial probiotic strain
- 2016-02-29
- World Journal of Microbiology and Biotechnology 32(4)
- - M. Majeed
  - K. Nagabhushanam
  - Sankaran Natarajan
  - A. Sivakumar
  - Talitha Eshuis-de Ruiter
  - Janine Booij-Veurink
  - Y. P. de Vries
  - Furqan Ali
- PubMed: 26925622
- DOI: 10.1007/s11274-016-2027-2
1 Insight on
- Improved Safety Profile
- Low evidence