May 2022 Supplement Research Papers

• May 1

  • Primary care experience on Stimunex® gocce in children with recurrent respiratory infections: a real-world study during the COVID-19 pandemic era.

    • 2022-05-01
    • RCT · n = 160
    • Allergologia et immunopathologia 50(3)
    • • Alessandro Giannattasio
      • Elena Poggi
      • Gianfranco Trapani
      • Cosimo Muia
      • Luisella Zanino
      • Massimo Landi
      • Giorgio Ciprandi

    • PubMed: 35527651
    • DOI: 10.15586/aei.v50i3.562

    5 Insights on

    • Reduced Symptom Severity
    • Improved Treatment Efficacy
    • Reduced Upper Respiratory Infection
    • Reduced Lower Respiratory Infection
    • Reduced Duration of Respiratory Infection

    • High evidence
    • Large Human Trial
• May 2

  • The right bug in the right place: opportunities for bacterial vaginosis treatment.

    • 2022-05-02
    • Review
    • NPJ biofilms and microbiomes 8(1)
    • • Shengru Wu
      • Luisa Warchavchik Hugerth
      • Ina Schuppe-Koistinen
      • Juan Du

    • PubMed: 35501321
    • DOI: 10.1038/s41522-022-00295-y

    1 Insight on

    • Reduced Recurrence of Bacterial Vaginosis

    • Low evidence
• May 3

  • Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial.

    • 2022-05-03
    • RCT · n = 365
    • Circulation 145(18)
    • • Axel C P Diederichsen
      • Jes S Lindholt
      • Sören Möller
      • Kristian A Øvrehus
      • Søren Auscher
      • Jess Lambrechtsen
      • Susanne E Hosbond
      • Dilek H Alan
      • Grazina Urbonaviciene
      • Søren W Becker
      • Maise H Fredgart
      • Selma Hasific
      • Lars Folkestad
      • Oke Gerke
      • Lars Melholt Rasmussen
      • Jacob E Møller
      • Hans Mickley
      • Jordi S Dahl

    • PubMed: 35465686
    • DOI: 10.1161/circulationaha.121.057008

    1 Insight on

    • Reduced Dephosphorylated-Uncarboxylated Matrix Gla Protein Level

    • High evidence
    • Large Human Trial
    • Rigorous Journal

  • Lactiplantibacillus plantarum-12 Alleviates Inflammation and Colon Cancer Symptoms in AOM/DSS-Treated Mice through Modulating the Intestinal Microbiome and Metabolome

    • 2022-05-03
    • Clinical Trial
    • Nutrients 14(9)
    • • Fenglian Ma
      • Mengying Sun
      • Yinglong Song
      • Arong Wang
      • Shujuan Jiang
      • Fang Qian
      • Guangqing Mu
      • Y. Tuo

    • PubMed: 35565884
    • DOI: 10.3390/nu14091916

    4 Insights on

    • Altered Fecal Metabolite Levels
    • Reduced Inflammation Levels
    • Improved Gut Microbiota Balance
    • Improved Colon Cancer Symptoms

    • Low evidence
    • Animal Study
• May 5

  • Continuous Ingestion of Lacticaseibacillus rhamnosus JB-1 during Chronic Stress Ensures Neurometabolic and Behavioural Stability in Rats

    • 2022-05-05
    • RCT · n = 20
    • International Journal of Molecular Sciences 23(9)
    • • A. Chudzik
      • Tymoteusz Slowik
      • Katarzyna Kochalska
      • A. Pankowská
      • Artur Łazorczyk
      • M. Andres-Mach
      • R. Rola
      • G. Stanisz
      • Anna Orzyłowska

    • PubMed: 35563564
    • DOI: 10.3390/ijms23095173

    3 Insights on

    • Reduced Anxiety Levels
    • Stable Brain Metabolite Levels
    • Prevented Neurometabolic Decline

    • Low evidence
    • Animal Study
• May 7

  • Lactiplantibacillus plantarum J‐15 reduced calcium oxalate kidney stones by regulating intestinal microbiota, metabolism, and inflammation in rats

    • 2022-05-07
    • Clinical Trial
    • The FASEB Journal 36(6)
    • • Lei Tian
      • Yu Liu
      • Xiaofang Xu
      • Pengrui Jiao
      • Gaofei Hu
      • Yaqian Cui
      • Jixiang Chen
      • Yuchen Ma
      • X. Jin
      • Kun-jie Wang
      • Qun Sun

    • PubMed: 35524736
    • DOI: 10.1096/fj.202101972RR

    4 Insights on

    • Improved Intestinal Barrier Function
    • Modulated Intestinal Metabolite Profile
    • Reduced Renal Crystalline Deposits
    • Reduced Urinary Oxalic Acid Levels

    • Low evidence
    • Rigorous Journal
    • Animal Study
• May 9

  • Assessments of Probiotic Potentials of Lactiplantibacillus plantarum Strains Isolated From Chinese Traditional Fermented Food: Phenotypic and Genomic Analysis

    • 2022-05-09
    • Frontiers in Microbiology 13
    • • Yuwei Sun
      • Shiyao Zhang
      • Hong Li
      • Jiang Zhu
      • Zhijia Liu
      • Xiaosong Hu
      • Junjie Yi

    • PubMed: 35615501
    • DOI: 10.3389/fmicb.2022.895132

    2 Insights on

    • Increased Antibacterial Activity
    • Increased Antioxidant Capacity

    • Low evidence
• May 10

  • 20 Years of Legislation - How Australia Has Responded to the Challenge of Regulating Genetically Modified Organisms in the Clinic.

    • 2022-05-10
    • Review
    • Frontiers in medicine 9
    • • Gabrielle M O'Sullivan
      • Joshua G Philips
      • Heidi J Mitchell
      • Michael Dornbusch
      • John E J Rasko

    • PubMed: 35620726
    • DOI: 10.3389/fmed.2022.883434

    2 Insights on

    • Improved Gastrointestinal Symptoms
    • Improved Defecation Condition

    • Low evidence
• May 11

  • Clustering Analysis of the Multi-Microbial Consortium by Lactobacillus Species Against Vaginal Dysbiosis Among Ecuadorian Women

    • 2022-05-11
    • Observational · n = 436
    • Frontiers in Cellular and Infection Microbiology 12
    • • David Pacha-Herrera
      • Maria P. Erazo-Garcia
      • Dario F. Cueva
      • M. Orellana
      • Pamela Borja-Serrano
      • Camila Arboleda
      • E. Tejera
      • A. Machado

    • PubMed: 35646732
    • DOI: 10.3389/fcimb.2022.863208

    3 Insights on

    • Improved Vaginal Microbiota Balance
    • Reduced Aerobic Vaginitis Risk
    • Protection Against Vaginal Dysbiosis

    • High evidence

  • Bifidobacterium longum relieves constipation by regulating the intestinal barrier of mice.

    • 2022-05-11
    • Clinical Trial
    • Food & Function 13(9)
    • • Linlin Wang
      • Mao-zhou Chai
      • Jialiang Wang
      • Q. Yu
      • G. Wang
      • H. Zhang
      • Jianxin Zhao
      • Wei Chen

    • PubMed: 35394000
    • DOI: 10.1039/d1fo04151g

    12 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Colonic Inflammation
    • Reduced Intestinal Inflammation
    • Reduced Inflammation Levels
    • Relieved Constipation
    • Increased Fecal Water Content
    • Regulated Intestinal Barrier Function
    • Reduced Inflammation
    • Improved Intestinal Motility
    • Reduced AQP8 Expression in Colon
    • Improved Constipation Relief
    • Prevention of Intestinal Barrier Damage

    • Low evidence
    • Animal Study

  • Effect of Oral Intake of Lactiplantibacillus plantarum APsulloc 331261 (GTB1TM) on Diarrhea-Predominant Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study

    • 2022-05-11
    • RCT · n = 27
    • Nutrients 14(10)
    • • Kyoungmi Jung
      • A. Kim
      • Ji-Hae Lee
      • Donghyun Cho
      • Juyeon Seo
      • Eun Sung Jung
      • Hye-Ji Kang
      • J. Roh
      • Wang Z Kim

    • PubMed: 35631156
    • DOI: 10.3390/nu14102015

    14 Insights on

    • Increased Fecal Lactobacilli
    • Improved Gastrointestinal Health
    • Reduced Bloating
    • Improved General IBS Symptoms
    • Improved Quality of Life
    • Reduced Abdominal Pain
    • Improved Intestinal Function
    • Increased Beneficial Gut Microbiota
    • Reduced Diarrhea Frequency
    • Global Relief of IBS Symptoms
    • Improved Quality of Life for IBS-D Patients
    • Increased Relative Abundance of Beneficial Microbiota (Lactobacillus)
    • Reduced Sense of Incomplete Evacuation
    • Improved Symptom Relief in IBS-D Patients

    • High evidence

  • Immunomodulatory effects of mixed Lactobacillus plantarum on lipopolysaccharide-induced intestinal injury in mice.

    • 2022-05-11
    • Clinical Trial
    • Food & Function 13(9)
    • • Jiahuan Dong
      • Lijun Ping
      • Kangyong Zhang
      • H. Tang
      • Jie Liu
      • Deyu Liu
      • Li Zhao
      • S. Evivie
      • Bailiang Li
      • G. Huo

    • PubMed: 35395665
    • DOI: 10.1039/d1fo04204a

    7 Insights on

    • Improved Abundance of Beneficial Bacteria
    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Myeloperoxidase Levels
    • Increased CD4+ T Cell Count
    • Reduced Intestinal Tissue Injury
    • Reduced Serum D-Lactate Levels
    • Increased Abundance of Beneficial Gut Genera

    • Low evidence
    • Animal Study

  • A novel Lactobacillus bulgaricus isolate can maintain the intestinal health, improve the growth performance and reduce the colonization of E. coli O157:H7 in broilers

    • 2022-05-11
    • RCT · n = 80
    • British Poultry Science 63(5)
    • • L. Xiang
      • Z. Ying
      • M. Xue
      • P. Xiaoxian
      • L. Xiaorong
      • L. Chunyang
      • W. Yu
      • L. Mingcheng
      • L. Binxian

    • PubMed: 35383527
    • DOI: 10.1080/00071668.2022.2062220

    8 Insights on

    • Improved Gastrointestinal Health
    • Reduced Inflammatory Response
    • Reduced Inflammatory Markers
    • Improved Intestinal Function
    • Improved Growth Performance
    • Increased Villus Height to Crypt Depth Ratio
    • Reduced E. coli O157:H7 Colonization
    • Improved Intestinal Microflora Diversity

    • Low evidence
    • Animal Study
• May 12

  • The Complex Role of Lactic Acid Bacteria in Food Detoxification.

    • 2022-05-12
    • Review
    • Nutrients 14(10)
    • • Penka Petrova
      • Alexander Arsov
      • Flora Tsvetanova
      • Tsvetomila Parvanova-Mancheva
      • Evgenia Vasileva
      • Lidia Tsigoriyna
      • Kaloyan Petrov

    • PubMed: 35631179
    • DOI: 10.3390/nu14102038

    1 Insight on

    • Improved Detoxification

    • Moderate evidence
    • Rigorous Journal
• May 14

  • Effect of ancient Khorasan wheat on gut microbiota, inflammation, and short-chain fatty acid production in patients with fibromyalgia.

    • 2022-05-14
    • RCT
    • World journal of gastroenterology 28(18)
    • • Simone Baldi
      • Giuditta Pagliai
      • Monica Dinu
      • Leandro Di Gloria
      • Giulia Nannini
      • Lavinia Curini
      • Marco Pallecchi
      • Edda Russo
      • Elena Niccolai
      • Giovanna Danza
      • Stefano Benedettelli
      • Giovanna Ballerini
      • Barbara Colombini
      • Gianluca Bartolucci
      • Matteo Ramazzotti
      • Francesco Sofi
      • Amedeo Amedei

    • PubMed: 35664958
    • DOI: 10.3748/wjg.v28.i18.1965

    6 Insights on

    • Improved Sleep Quality
    • Reduced Fibromyalgia Symptom Severity
    • Improved Tiredness Symptom Score
    • Reduced Widespread Pain Index Score
    • Reduced Symptom Severity Scale Score
    • Improved Sleep-Related and Safety Behaviour Questionnaire Score

    • High evidence
• May 16

  • Bacteriocin-Producing Probiotic Lactic Acid Bacteria in Controlling Dysbiosis of the Gut Microbiota.

    • 2022-05-16
    • Review
    • Frontiers in cellular and infection microbiology 12
    • • Anjana
      • Santosh Kumar Tiwari

    • PubMed: 35651753
    • DOI: 10.3389/fcimb.2022.851140

    4 Insights on

    • Improved Gut Microbiota Balance
    • Modulated Gut Microbiota
    • Reduced Inflammatory Bowel Disease Symptoms
    • Reduced Bacterial Colonization

    • Moderate evidence
    • Highly Cited
• May 17

  • Lactiplantibacillus plantarum Y42 in Biofilm and Planktonic States Improves Intestinal Barrier Integrity and Modulates Gut Microbiota of Balb/c Mice

    • 2022-05-17
    • Clinical Trial
    • Foods 11(10)
    • • Lijuan Zhang
      • Yuan Meng
      • Jiayi Li
      • Jiang Yu
      • Guangqing Mu
      • Y. Tuo

    • PubMed: 35627021
    • DOI: 10.3390/foods11101451

    5 Insights on

    • Improved Intestinal Barrier Function
    • Improved Immune Function
    • Improved Immune Response
    • Reduced Proinflammatory Signaling
    • Increased Secretory IgA Level

    • Low evidence
    • Rigorous Journal
    • Animal Study
• May 24

  • Effects of Dietary Supplementation With Clostridium butyricum on Growth Performance, Apparent Digestibility, Blood Metabolites, Ruminal Fermentation and Bacterial Communities of Fattening Goats

    • 2022-05-24
    • RCT
    • Frontiers in Nutrition 9
    • • Chengrui Zhang
      • Qingyuan Yu
      • Jihong Wang
      • Yidong Yu
      • Yonggen Zhang
      • Yukun Sun

    • PubMed: 35685891
    • DOI: 10.3389/fnut.2022.888191

    3 Insights on

    • Reduced Fecal Clostridium Levels
    • Increased Blood pH
    • Altered Relative Abundance of Specific Bacteria

    • High evidence
• May 25

  • Bifidobacterium longum Ameliorates Ovariectomy-Induced Bone Loss via Enhancing Anti-Osteoclastogenic and Immunomodulatory Potential of Regulatory B Cells (Bregs)

    • 2022-05-25
    • Clinical Trial
    • Frontiers in Immunology 13
    • • Leena Sapra
      • Niti Shokeen
      • Konica Porwal
      • C. Saini
      • A. Bhardwaj
      • M. Mathew
      • P. Mishra
      • N. Chattopadhyay
      • Hamid Y. Dar
      • B. Verma
      • R. Srivastava

    • PubMed: 35693779
    • DOI: 10.3389/fimmu.2022.875788

    4 Insights on

    • Improved Treg/Th-17 Balance
    • Reduced Osteoclast Number
    • Reduced Bone Loss
    • Increased Anti-Osteoclastogenic Cytokine Production

    • Low evidence
    • Animal Study

  • Health-Promoting Nature of Lactococcus lactis IBB109 and Lactococcus lactis IBB417 Strains Exhibiting Proliferation Inhibition and Stimulation of Interleukin-18 Expression in Colorectal Cancer Cells

    • 2022-05-25
    • Frontiers in Microbiology 13
    • • Przemysław Sałański
      • M. Kowalczyk
      • J. Bardowski
      • A. Szczepankowska

    • PubMed: 35694291
    • DOI: 10.3389/fmicb.2022.822912

    2 Insights on

    • Improved Antibiotic Sensitivity
    • Improved Intestinal Cell Adhesion

    • Low evidence

  • The production and biochemical characterization of α-carbonic anhydrase from Lactobacillus rhamnosus GG.

    • 2022-05-25
    • Applied microbiology and biotechnology 106(11)
    • • Linda J Urbański
      • Silvia Bua
      • Andrea Angeli
      • Reza Zolfaghari Emameh
      • Harlan R Barker
      • Marianne Kuuslahti
      • Vesa P Hytönen
      • Seppo Parkkila
      • Claudiu T Supuran

    • PubMed: 35612631
    • DOI: 10.1007/s00253-022-11990-3

    2 Insights on

    • No Significant Effect on Probiotic Growth
    • No Significant Effect on Cell Growth

    • Low evidence
• May 26

  • Overall Rebalancing of Gut Microbiota Is Key to Autism Intervention.

    • 2022-05-26
    • Review
    • Frontiers in psychology 13
    • • Chang Lu
      • Jiaqi Rong
      • Changxing Fu
      • Wenshi Wang
      • Jing Xu
      • Xing-Da Ju

    • PubMed: 35712154
    • DOI: 10.3389/fpsyg.2022.862719

    5 Insights on

    • Improved Gastrointestinal Health
    • Improved Gut Microbiota Balance
    • Improved Behavioral Health
    • Improved ASD Symptoms
    • Improved Neurobehavioral Function

    • Low evidence
• May 27

  • Protective Effect of Bifidobacterium lactis JYBR-190 on Intestinal Mucosal Damage in Chicks Infected With Salmonella pullorum.

    • 2022-05-27
    • Frontiers in veterinary science 9
    • • Liangyu Yang
      • Yuanhong Chen
      • Qian Bai
      • Xi Chen
      • Yunteng Shao
      • Ronghai Wang
      • Fengping He
      • Ganzhen Deng

    • PubMed: 35692296
    • DOI: 10.3389/fvets.2022.879805

    3 Insights on

    • Reduced Intestinal Inflammation
    • Enhanced Mucosal Immune Function
    • Improved Intestinal Integrity

    • Low evidence
• May 31

  • Effects of beta-alanine supplementation on body composition: a GRADE-assessed systematic review and meta-analysis.

    • 2022-05-31
    • Meta-Analysis · n = 492
    • Journal of the International Society of Sports Nutrition 19(1)
    • • Damoon Ashtary-Larky
      • Reza Bagheri
      • Matin Ghanavati
      • Omid Asbaghi
      • Alexei Wong
      • Jeffrey R Stout
      • Katsuhiko Suzuki

    • PubMed: 35813845
    • DOI: 10.1080/15502783.2022.2079384

    4 Insights on

    • Reduced Body Fat Percentage
    • Reduced Body Fat Mass
    • Increased Fat-Free Mass
    • Reduced Body Mass

    • High evidence
• Undated – 2 supplement studies

  • Habitual Green Kiwifruit Consumption Is Associated with a Reduction in Upper Gastrointestinal Symptoms: A Systematic Scoping Review.

    • 2022-05
    • Systematic Review · n = 661
    • Advances in nutrition (Bethesda, Md.) 13(3)
    • • Simone B Bayer
      • Chris M Frampton
      • Richard B Gearry
      • Giovanni Barbara

    • PubMed: 35266507
    • DOI: 10.1093/advances/nmac025

    3 Insights on

    • Reduced Straining
    • Reduced Abdominal Pain
    • Reduced Abdominal Discomfort

    • High evidence

  • Vitamin K2 as a potential therapeutic candidate for the prevention of muscle cramps in hemodialysis patients: A prospective multicenter, randomized, controlled, crossover pilot trial.

    • 2022-05
    • RCT · n = 523
    • Nutrition (Burbank, Los Angeles County, Calif.) 97
    • • Dan Xu
      • AnXiu Yang
      • Ruijun Ren
      • Zhong Shan
      • Yuan Ming Li
      • Jing Tan

    • PubMed: 35203045
    • DOI: 10.1016/j.nut.2022.111608

    4 Insights on

    • Reduced Muscle Cramp Frequency
    • Reduced Muscle Cramp Duration
    • Reduced Muscle Cramp Severity
    • Increased Gastrointestinal Discomfort

    • High evidence
    • Large Human Trial