March 2023 Supplement Research Papers

• March 1

  • Role of Probiotics and Synbiotics in Preventing Chemoradiotherapy-Associated Toxicity in Colorectal Cancer Patients: A Systematic Review.

    • 2023-03-01
    • Systematic Review
    • Iranian journal of medical sciences 48(2)
    • • Reza Mahdavi
      • Elnaz Faramarzi
      • Zeinab Nikniaz
      • Fatemeh FarshiRadvar

    • PubMed: 36895464
    • DOI: 10.30476/ijms.2022.92793.2411

    5 Insights on

    • Improved Quality of Life
    • Reduced Abdominal Discomfort
    • Reduced Diarrhea
    • Reduced Radiation-Associated Diarrhea
    • Reduced Bowel Toxicity-Related Hospital Care

    • High evidence

  • Cupuassu juice fermentation by lactiplantibacillus plantarum Lp62 produces an antioxidant enriched probiotic beverage.

    • 2023-03-01
    • Letters in Applied Microbiology 76(3)
    • • Lucas Alvarenga da Silva
      • Bianca Silva de Vasconcelos
      • D. K. T. Moreira
      • R. Rezende
      • C. C. Romano
      • Thalis Ferreira Dos Santos

    • PubMed: 36881723
    • DOI: 10.1093/lambio/ovad032

    2 Insights on

    • Reduced Pathogen Activity
    • Increased Antioxidant Capacity

    • Low evidence
• March 2

  • Use of Streptococcus salivarius K12 in supporting the mucosal immune function of active young subjects: A randomised double-blind study.

    • 2023-03-02
    • RCT
    • Frontiers in immunology 14
    • • Alexander Bertuccioli
      • Marco Gervasi
      • Giosuè Annibalini
      • Beatrice Binato
      • Fabrizio Perroni
      • Marco B L Rocchi
      • Davide Sisti
      • Stefano Amatori

    • PubMed: 36936914
    • DOI: 10.3389/fimmu.2023.1129060

    2 Insights on

    • Increased Salivary sIgA Levels
    • Reduced Upper Respiratory Tract Infection Episode

    • High evidence
• March 3

  • Vaginal and tumor microbiomes in gynecological cancer (Review).

    • 2023-03-03
    • Review
    • Oncology letters 25(4)
    • • Mengzhen Han
      • Na Wang
      • Wenjie Han
      • Meng Ban
      • Tao Sun
      • Junnan Xu

    • PubMed: 36936020
    • DOI: 10.3892/ol.2023.13739

    2 Insights on

    • Improved Vaginal Health
    • Improved Vaginal Microbiota

    • Low evidence

  • The effects of Bacillus coagulans MTCC 5856 on functional gas and bloating in adults: A randomized, double-blind, placebo-controlled study

    • 2023-03-03
    • RCT · n = 70
    • Medicine 102(9)
    • • M. Majeed
      • K. Nagabhushanam
      • Shaji Paulose
      • S. Arumugam
      • Lakshmi A Mundkur

    • PubMed: 36862903
    • DOI: 10.1097/MD.0000000000033109

    13 Insights on

    • Improved Bowel Movement Frequency
    • Improved Stool Consistency
    • Reduced Gastrointestinal Symptoms
    • Reduced Abdominal Pain
    • No Reported Adverse Effects
    • No Adverse Events Observed
    • Improved Gastrointestinal Symptoms
    • Absence of Adverse Events
    • Improved Global Evaluation of Patient Scores
    • Normalized Stool Type
    • Improved Bristol Stool Type
    • No Significant Adverse Events or Changes in Clinical Parameters
    • Reduced Gastrointestinal Symptom Rating Scale Score

    • High evidence

  • Lactobacillus salivarius WZ1 Inhibits the Inflammatory Injury of Mouse Jejunum Caused by Enterotoxigenic Escherichia coli K88 by Regulating the TLR4/NF-κB/MyD88 Inflammatory Pathway and Gut Microbiota

    • 2023-03-03
    • RCT
    • Microorganisms 11(3)
    • • Zhe Wei
      • Ziqi He
      • Tongyao Wang
      • Xiaoxuan Wang
      • Tiancheng Wang
      • M. Long

    • PubMed: 36985229
    • DOI: 10.3390/microorganisms11030657

    6 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Pro-Inflammatory Cytokines
    • Reduced Intestinal Inflammation
    • Improved Abundance of Beneficial Bacteria
    • Reduced Harmful Gut Bacteria
    • Reduced Inflammatory Injury

    • Low evidence
    • Animal Study
• March 6

  • Exopolysaccharides of Lactobacillus rhamnosus GG ameliorate Salmonella typhimurium-induced intestinal inflammation via the TLR4/NF-κB/MAPK pathway.

    • 2023-03-06
    • Journal of animal science and biotechnology 14(1)
    • • Jinze Li
      • Qiuke Li
      • Qianhui Wu
      • Nan Gao
      • Zhihua Wang
      • Yang Yang
      • Anshan Shan

    • PubMed: 36872332
    • DOI: 10.1186/s40104-023-00830-7

    6 Insights on

    • Reduced Intestinal Inflammation
    • Reduced Oxidative Stress
    • Reduced Oxidative Stress in Intestinal Epithelial Cells
    • Reduced Pathogenic Bacterial Invasion
    • Improved Weight Loss
    • Improved Intestinal Injury

    • Low evidence

  • The Probiotic Lactobacillus sakei Subsp. Sakei and Hawthorn Extract Supplements Improved Growth Performance, Digestive Enzymes, Immunity, and Resistance to the Pesticide Acetamiprid in Common Carp (Cyprinus carpio)

    • 2023-03-06
    • Aquaculture Nutrition 2023
    • • Abdul-Hassan Mahdi Salih
      • Indrajit Patra
      • Ramaswamy Sivaraman
      • Rahim Alhamzawi
      • Kakhor M. Khalikov
      • Z. H. Al-qaim
      • Sahar Golgouneh
      • M. Jawad
      • A. H. Adhab
      • Andrés Leonardo Vázquez-Cárdenas
      • Safoura Abarghouei

    • PubMed: 36922956
    • DOI: 10.1155/2023/8506738

    5 Insights on

    • Improved Growth Performance
    • Enhanced Digestive Enzyme Activity
    • Reduced Liver Enzyme Levels
    • Increased Lactobacilli Levels
    • Increased Intestinal Lactobacillus sakei Levels

    • Low evidence
• March 7

  • Amelioration of alcohol-induced acute liver injury in C57BL/6 mice by a mixture of TCM phytochemicals and probiotics with antioxidative and anti-inflammatory effects.

    • 2023-03-07
    • Frontiers in nutrition 10
    • • Zhiguo Li
      • Xuexun Fang
      • Xin Hu
      • Congcong Li
      • Youzhong Wan
      • Dahai Yu

    • PubMed: 36960204
    • DOI: 10.3389/fnut.2023.1144589

    4 Insights on

    • Reduced Proinflammatory Cytokine Production
    • Reduced Inflammation
    • Reduced Oxidative Stress
    • Reduced Alcohol-Induced Liver Injury

    • Low evidence

  • Probiotic activity of ropy Lactiplantibacillus plantarum NA isolated from Chinese northeast sauerkraut and comparative evaluation of its live and heat-killed cells on antioxidant activity and RAW 264.7 macrophage stimulation.

    • 2023-03-07
    • Food & Function 14(5)
    • • Xiaoqing Xu
      • Yu Qiao
      • Qing Peng
      • V. Dia
      • B. Shi

    • PubMed: 36804706
    • DOI: 10.1039/d2fo03761k

    13 Insights on

    • Improved Immune Response
    • Increased Antioxidant Activity
    • Reduced Serum Cholesterol Levels
    • Enhanced Immune Response
    • Improved Immunomodulation
    • Reduced Free Radical Levels
    • Increased Antibacterial Activity
    • Enhanced Immune Function
    • Increased Antioxidant Capacity
    • Increased Nitric Oxide Production
    • Increased Antibiotic Susceptibility
    • Increased Resistance to Simulated Gastrointestinal Conditions
    • Increased Reactive Oxygen Species Production

    • Low evidence
• March 8

  • Remodeling of the gut microbiome by Lactobacillus johnsonii alleviates the development of acute myocardial infarction

    • 2023-03-08
    • Clinical Trial
    • Frontiers in Microbiology 14
    • • Xinqin Zhong
      • Yucui Zhao
      • Lu Huang
      • Jiarui Liu
      • Kaiyue Wang
      • Xiumei Gao
      • Xin Zhao
      • Xiaoying Wang

    • PubMed: 36970663
    • DOI: 10.3389/fmicb.2023.1140498

    5 Insights on

    • Improved Barrier Integrity
    • Preserved Cardiac Function
    • Delayed Cardiac Pathology
    • Reduced Myocardial Injury Cytokines
    • Microbiome Remodeling

    • Low evidence
    • Animal Study
• March 9

  • The anti-inflammatory activity of GABA-enriched Moringa oleifera leaves produced by fermentation with Lactobacillus plantarum LK-1.

    • 2023-03-09
    • Frontiers in nutrition 10
    • • Long Zheng
      • Xuli Lu
      • Shengtao Yang
      • Ying Zou
      • Fanke Zeng
      • Shaohao Xiong
      • Yupo Cao
      • Wei Zhou

    • PubMed: 36969807
    • DOI: 10.3389/fnut.2023.1093036

    2 Insights on

    • Reduced Proinflammatory Signaling
    • Reduced Inflammation

    • Low evidence
• March 10

  • Beneficial insights into postbiotics against colorectal cancer.

    • 2023-03-10
    • Review
    • Frontiers in nutrition 10
    • • Dingka Song
      • Xiuli Wang
      • Yongjing Ma
      • Ning-Ning Liu
      • Hui Wang

    • PubMed: 36969804
    • DOI: 10.3389/fnut.2023.1111872

    2 Insights on

    • Reduced Risk of Colorectal Cancer
    • Improved Colorectal Cancer Outcomes

    • Low evidence

  • Emerging Role and Place of Probiotics in the Management of Pediatric Neurodevelopmental Disorders.

    • 2023-03-10
    • Review
    • Euroasian journal of hepato-gastroenterology 12(2)
    • • Himani Narula Khanna
      • Sushovan Roy
      • Aqsa Shaikh
      • Viswanath Bandi

    • PubMed: 36959989
    • DOI: 10.5005/jp-journals-10018-1384

    2 Insights on

    • Improved Autism Spectrum Disorder Symptoms
    • Improved Attention-Deficit Hyperactivity Disorder Symptom

    • Low evidence

  • Efficacy of Bifidobacterium longum alone or in multi-strain probiotic formulations during early life and beyond

    • 2023-03-10
    • Review
    • Gut Microbes 15(1)
    • • S. Mills
      • Bo Yang
      • Graeme J. Smith
      • C. Stanton
      • R. Ross

    • PubMed: 36896934
    • DOI: 10.1080/19490976.2023.2186098

    4 Insights on

    • Improved Immune Function
    • Improved Neurobehavioral Function
    • Unclear / Not Reported in Provided Abstract
    • No Reported Health Outcome

    • Low evidence
• March 12

  • The Effects of Probiotics/Synbiotics on Glucose and Lipid Metabolism in Women with Gestational Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials.

    • 2023-03-12
    • Meta-Analysis · n = 11
    • Nutrients 15(6)
    • • Jinhao Mu
      • Xian Guo
      • Yanbing Zhou
      • Guoxia Cao

    • PubMed: 36986107
    • DOI: 10.3390/nu15061375

    6 Insights on

    • Improved Insulin Sensitivity
    • Improved Insulin Levels
    • Reduced Blood Cholesterol
    • Improved Glucose Metabolism
    • Improved Total Cholesterol Levels
    • Reduced Plasma Glucose Levels

    • High evidence
    • Rigorous Journal
• March 14

  • Early Probiotic Supplementation of Healthy Term Infants with Bifidobacterium longum subsp. infantis M-63 Is Safe and Leads to the Development of Bifidobacterium-Predominant Gut Microbiota: A Double-Blind, Placebo-Controlled Trial

    • 2023-03-14
    • RCT · n = 110
    • Nutrients 15(6)
    • • A. Hiraku
      • Setsuko Nakata
      • Mai Murata
      • Chendong Xu
      • N. Mutoh
      • Satoshi Arai
      • T. Odamaki
      • N. Iwabuchi
      • Miyuki Tanaka
      • Takahisa Tsuno
      • Masahiko Nakamura

    • PubMed: 36986131
    • DOI: 10.3390/nu15061402

    22 Insights on

    • Reduced Faecal pH
    • Improved Bowel Movement Frequency
    • Increased Gut Bifidobacteria
    • Reduced Stool Frequency
    • Reduced Stool Volume
    • Increased Acetic Acid Levels in Feces
    • Increased Serum Immunoglobulin A (IgA) Levels
    • Increased Fecal Secretory IgA Levels
    • Increased Fecal Acetate Levels
    • Increased Fecal Immunoglobulin A Levels
    • Reduced Frequency of Defecation
    • Reduced Watery Stools
    • Absence of Adverse Events
    • No Adverse Food Reactions
    • Increased Immunoglobulin A Levels
    • Increased Bifidobacterium Levels
    • Safety of Bifidobacterium infantis Supplementation
    • Reduced Stool pH
    • Increased Stool IgA Levels
    • Increased Acetic Acid in Stool
    • Increased Stool Immunoglobulin A (IgA)
    • Decreased Stool pH

    • High evidence

  • Changes in the gut microbiota composition of healthy young volunteers after administration of Lacticaseibacillus rhamnosus LRa05: A placebo-controlled study

    • 2023-03-14
    • RCT · n = 100
    • Frontiers in Nutrition 10
    • • Zhonghui Gai
      • Yao Dong
      • Fei Xu
      • Junli Zhang
      • Yujiao Yang
      • Yuwen Wang

    • PubMed: 36998912
    • DOI: 10.3389/fnut.2023.1105694

    3 Insights on

    • Increased Lacticaseibacillus Abundance
    • Reduced Sellimonas Abundance
    • Reduced Salmonella Infection Pathway

    • High evidence
• March 15

  • Paradoxical Reactions to Anti-TNFα and Anti-IL-17 Treatment in Psoriasis Patients: Are Skin and/or Gut Microbiota Involved?

    • 2023-03-15
    • Review
    • Dermatology and therapy 13(4)
    • • Zuzana Jiraskova Zakostelska
      • Zuzana Reiss
      • Helena Tlaskalova-Hogenova
      • Filip Rob

    • PubMed: 36929119
    • DOI: 10.1007/s13555-023-00904-4

    4 Insights on

    • Improved Immune Function
    • Reduced Blood Pressure
    • Improved Skin Barrier Function
    • No Direct Health Outcome Reported

    • Low evidence
• March 21

  • Exploring the Potential of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 as Promising Psychobiotics Using SHIME

    • 2023-03-21
    • Nutrients 15(6)
    • • Fellipe Lopes de Oliveira
      • Mateus Kawata Salgaço
      • Marina Toscano de Oliveira
      • V. Mesa
      • A. Sartoratto
      • Antonio Medeiros Peregrino
      • Williams Santos Ramos
      • K. Sivieri

    • PubMed: 36986251
    • DOI: 10.3390/nu15061521

    3 Insights on

    • Increased Anti-Inflammatory Cytokine Levels
    • Increased Short-Chain Fatty Acid Production
    • Reduced Ammonia Levels

    • Low evidence
• March 22

  • Cognitive and negative symptoms in schizophrenia with L-Carnosine adjuvant therapy - A randomized double-blind placebo-controlled study.

    • 2023-03-22
    • RCT
    • Pharmacology research & perspectives 11(2)
    • • Hema Tharoor
      • Sindhu Maran
      • Antra K Chandan
      • Manikandan Pari
      • Shruti Rao
      • Jothilakshmi Durairaj

    • PubMed: 36946070
    • DOI: 10.1002/prp2.1074

    4 Insights on

    • Improved Cognitive Function
    • Improved Memory Function
    • Reduced Negative Symptoms
    • Improved Attention Score

    • High evidence
• March 23

  • Conditioning therapy with N-acetyl-L-cysteine, decitabine and modified BUCY regimen for myeloid malignancies patients prior to allogeneic hematopoietic stem cell transplantation.

    • 2023-03-23
    • RCT · n = 78
    • American journal of hematology 98(6)
    • • Yaqiong Tang
      • Ziyan Zhang
      • Silu Liu
      • Yifang Yao
      • Tingting Pan
      • Jiaqian Qi
      • Huizhu Kang
      • Yuejun Liu
      • Chengsen Cai
      • Meng Zhou
      • Xuefeng He
      • Xiaohui Hu
      • Xiao Ma
      • Depei Wu
      • Yue Han

    • PubMed: 36880836
    • DOI: 10.1002/ajh.26903

    5 Insights on

    • Increased Platelet Count
    • Improved Overall Survival
    • Reduced Relapse Rate
    • Improved Event-Free Survival
    • Reduced Reactive Oxygen Species Level

    • High evidence

  • Bioavailability of Bioactive Compounds from Reconstituted Grapefruit Juice as Affected by the Obtention Process.

    • 2023-03-23
    • Clinical Trial
    • Molecules (Basel, Switzerland) 28(7)
    • • María Del Mar Camacho
      • Juan José Martínez-Lahuerta
      • Eva García-Martínez
      • Marta Igual
      • Nuria Martínez-Navarrete

    • PubMed: 37049665
    • DOI: 10.3390/molecules28072904

    2 Insights on

    • Increased Serum Vitamin C Level
    • Increased Naringenin Level

    • Moderate evidence
• March 24

  • Anti-Inflammation and Anti-Melanogenic Effects of Maca Root Extracts Fermented Using Lactobacillus Strains.

    • 2023-03-24
    • Antioxidants (Basel, Switzerland) 12(4)
    • • Jisun Yang
      • Hyeijin Cho
      • Minchan Gil
      • Kyung Eun Kim

    • PubMed: 37107174
    • DOI: 10.3390/antiox12040798

    3 Insights on

    • Reduced Inflammation
    • Reduced Melanin Production
    • Reduced Melanogenesis

    • Low evidence

  • Secondary Metabolites with Antifungal Activities from Mangrove Derived Fungus Monascus purpureus WMD2424.

    • 2023-03-24
    • Marine drugs 21(4)
    • • Ming-Der Wu
      • Jih-Jung Chen
      • Ming-Jen Cheng

    • PubMed: 37103340
    • DOI: 10.3390/md21040200

    1 Insight on

    • Antifungal Activity Against Saccharomyces cerevisiae

    • Low evidence

  • Association Between Vitamin B6 and the Risk of Colorectal Cancer: A Meta-analysis of Observational Studies.

    • 2023-03-24
    • Meta-Analysis
    • Nutrition and cancer 75(5)
    • • Jianxiong Lai
      • Mingqiao Guo
      • Dongmei Wang
      • Kuan Liu
      • Dengmin Hu
      • Jian Li

    • PubMed: 36961108
    • DOI: 10.1080/01635581.2023.2191823

    1 Insight on

    • Reduced Risk of Colorectal Cancer

    • High evidence
• March 28

  • Effects of Probiotics on Glycemic Control and Metabolic Parameters in Gestational Diabetes Mellitus: Systematic Review and Meta-Analysis.

    • 2023-03-28
    • Meta-Analysis · n = 854
    • Nutrients 15(7)
    • • Enav Yefet
      • Liron Bar
      • Ido Izhaki
      • Rula Iskander
      • Manal Massalha
      • Johnny S Younis
      • Zohar Nachum

    • PubMed: 37049473
    • DOI: 10.3390/nu15071633

    2 Insights on

    • Reduced Birth Weight
    • Improved Glycemia

    • High evidence
    • Rigorous Journal

  • Clinical effects of Bifidobacterium as a probiotic on oral health: A systematic review.

    • 2023-03-28
    • Review
    • Dental research journal 20
    • • M Y Jayachandra
      • R Gayathiri
      • C N Aruna
      • Padma K Bhat
      • P M Arumugam

    • PubMed: 37180688
    • DOI: 10.4103/1735-3327.372649

    1 Insight on

    • Improved Oral Health

    • Low evidence
• March 31

  • Complete genome sequence of functional probiotic candidate Lactobacillus amylovorus CACC736.

    • 2023-03-31
    • Journal of animal science and technology 65(2)
    • • Soyeon Park
      • Jung-Ae Kim
      • Hyun-Jun Jang
      • Dae-Hyuk Kim
      • Yangseon Kim

    • PubMed: 37093924
    • DOI: 10.5187/jast.2022.e85

    3 Insights on

    • Improved Gastrointestinal Health
    • Improved Probiotic Functionality
    • Improved Animal Health

    • Low evidence
• Undated – 3 supplement studies

  • Long-Term Consumption of Nuts (Including Peanuts, Peanut Butter, Walnuts, and Other Nuts) in Relation to Risk of Frailty in Older Women: Evidence from a Cohort Study.

    • 2023-03
    • Observational · n = 704
    • The Journal of nutrition 153(3)
    • • Ruibin Wang
      • Marian T Hannan
      • Molin Wang
      • Andrea W Schwartz
      • Esther Lopez-Garcia
      • Francine Grodstein

    • PubMed: 36931754
    • DOI: 10.1016/j.tjnut.2023.01.003

    1 Insight on

    • Reduced Frailty Incidence

    • High evidence

  • Evidence for effect of l-serine, a novel therapy for GRIN2B-related neurodevelopmental disorder.

    • 2023-03
    • Observational
    • Molecular genetics and metabolism 138(3)
    • • B den Hollander
      • A R J Veenvliet
      • M Rothuizen-Lindenschot
      • P van Essen
      • G Peters
      • A Santos-Gómez
      • M Olivella
      • X Altafaj
      • M M Brands
      • B A W Jacobs
      • C D van Karnebeek

    • PubMed: 36758276
    • DOI: 10.1016/j.ymgme.2023.107523

    4 Insights on

    • Increased Energy Levels
    • Improved Psychomotor Development
    • Improved Cognitive Functioning
    • Improved Communication Skills

    • Low evidence

  • Infant blood concentrations of folate markers and catabolites are modified by 5,10-methylenetetrahydrofolate reductase C677T genotype and dietary folate source.

    • 2023-03
    • RCT · n = 182
    • The American journal of clinical nutrition 117(3)
    • • Rima Obeid
      • Ines Warnke
      • Anja Wittke
      • Igor Bendik
      • Barbara Troesch
      • Rotraut Schoop
      • Christina Hecht
      • Johann Demmelmair
      • Berthold Koletzko

    • PubMed: 36872017
    • DOI: 10.1016/j.ajcnut.2022.09.002

    2 Insights on

    • Increased Red Blood Cell Count
    • Increased Parabenzoylaminobenzoic Acid Concentration

    • High evidence
    • Large Human Trial