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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Saccharomyces boulardii as an adjuvant therapy for Helicobacter pylori eradication: A systematic review and meta‐analysis with trial sequential analysis
- 2019-08-14
- Meta-Analysis
- Helicobacter 24(5)
- - Ben‐Gang Zhou
  - Lingxiao Chen
  - Bohua Li
  - Lin-Yan Wan
  - Yao-Wei Ai
- PubMed: 31414551
- DOI: 10.1111/hel.12651
7 Insights on
- High evidence
The Application of Lactobacillus reuteri CCM 8617 and Flaxseed Positively Improved the Health of Mice Challenged with Enterotoxigenic E. coli O149:F4
- 2019-08-13
- RCT · n = 60
- Probiotics and Antimicrobial Proteins 12(3)
- - Z. Andrejčáková
  - D. Sopková
  - R. Vlčková
  - Z. Hertelyová
  - S. Gancarčíková
  - R. Nemcová
- PubMed: 31410766
- DOI: 10.1007/s12602-019-09578-x
4 Insights on
- Low evidence
- Animal Study
Effectiveness of oral intake of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 on Group B Streptococcus colonization during pregnancy: a midwifery-led double-blind randomized controlled pilot trial.
- 2019-08-13
- RCT
- The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 34(11)
- - Mary Sharpe
  - Vibhuti Shah
  - Tatiana Freire-Lizama
  - Elizabeth C Cates
  - Kory McGrath
  - Iuliana David
  - Sara Cowan
  - Janaya Letkeman
  - Emily Stewart-Wilson
- PubMed: 31362572
- DOI: 10.1080/14767058.2019.1650907
2 Insights on
- Reduced Vaginal Group B Streptococcus Colonization
- No Documented Adverse Effects
- High evidence
Probiotics Upregulate Trefoil Factors and Downregulate Pepsinogen in the Mouse Stomach.
- 2019-08-10
- International journal of molecular sciences 20(16)
- - Ghalia Khoder
  - Farah Al-Yassir
  - Asma Al Menhali
  - Prashanth Saseedharan
  - Subi Sugathan
  - Catherine Tomasetto
  - Sherif M Karam
- PubMed: 31405107
- DOI: 10.3390/ijms20163901
4 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Health Benefits of Lactobacillus gasseri CP2305 Tablets in Young Adults Exposed to Chronic Stress: A Randomized, Double-Blind, Placebo-Controlled Study
- 2019-08-10
- RCT · n = 60
- Nutrients 11(8)
- - K. Nishida
  - D. Sawada
  - Y. Kuwano
  - Hiroki Tanaka
  - K. Rokutan
- PubMed: 31405122
- DOI: 10.3390/nu11081859
10 Insights on
- High evidence
- Highly Cited
Effect of bovine milk fermented with Lactobacillus rhamnosus L8020 on periodontal disease in individuals with intellectual disability: a randomized clinical trial
- 2019-08-08
- RCT · n = 23
- Journal of Applied Oral Science 27
- - Oda Yuki
  - Chiaki Furutani
  - Yuika Mizota
  - Atsuko Wakita
  - Sumiyo Mimura
  - T. Kihara
  - M. Ohara
  - Yoshiyuki Okada
  - M. Okada
  - H. Nikawa
- PubMed: 31365710
- DOI: 10.1590/1678-7757-2018-0564
2 Insights on
- Reduced Probing Depth
- Reduced PMA Index
- High evidence
Lactobacillus plantarum CCFM8661 modulates bile acid enterohepatic circulation and increases lead excretion in mice.
- 2019-08-06
- Clinical Trial
- Food & Function 10(3)
- - Q. Zhai
  - Yang Liu
  - Chen Wang
  - DingWu Qu
  - Jianxin Zhao
  - Hao Zhang
  - F. Tian
  - Wei Chen
- PubMed: 30768114
- DOI: 10.1039/c8fo02554a
2 Insights on
- Increased Fecal Bile Acid Levels
- Increased Lead Excretion
- Low evidence
- Animal Study
A ropy exopolysaccharide producing strain Bifidobacterium longum subsp. longum YS108R alleviates DSS-induced colitis by maintenance of the mucosal barrier and gut microbiota modulation.
- 2019-08-05
- RCT · n = 8
- Food & Function 10(3)
- - Shuang Yan
  - Bo Yang
  - Jichun Zhao
  - Jianxin Zhao
  - C. Stanton
  - R. P. Ross
  - Hao Zhang
  - Wei Chen
- PubMed: 30806428
- DOI: 10.1039/c9fo00014c
4 Insights on
- Low evidence
- Highly Cited
- Animal Study
Fermented Foods: Definitions and Characteristics, Impact on the Gut Microbiota and Effects on Gastrointestinal Health and Disease.
- 2019-08-05
- Review
- Nutrients 11(8)
- - Eirini Dimidi
  - Selina Rose Cox
  - Megan Rossi
  - Kevin Whelan
- PubMed: 31387262
- DOI: 10.3390/nu11081806
4 Insights on
- High evidence
- Highly Cited
- Rigorous Journal
Recent advances in dairy goat products.
- 2019-08-01
- Review
- Asian-Australasian Journal of Animal Sciences. 32(8)
- - Lucia Sepe
  - Anastasio Argüello
- PubMed: 31357271
- DOI: 10.5713/ajas.19.0487
2 Insights on
- Increased Antioxidant Activity
- Improved Overall Health
- Low evidence
Improvement of cognitive functions by oral intake of Hericium erinaceus.
- 2019-08-01
- RCT
- Biomedical research (Tokyo, Japan) 40(4)
- - Yuusuke Saitsu
  - Akemi Nishide
  - Kenji Kikushima
  - Kuniyoshi Shimizu
  - Koichiro Ohnuki
- PubMed: 31413233
- DOI: 10.2220/biomedres.40.125
3 Insights on
- High evidence
The effects of Vitex agnus-castus on menstrual bleeding: A systematic review and meta-analysis.
- 2019-07-31
- Meta-Analysis
- Journal of complementary & integrative medicine 17(1)
- - Sanaz Mollazadeh
  - Mojgan Mirghafourvand
  - Nafiseh Ghassab Abdollahi
- PubMed: 31369395
- DOI: 10.1515/jcim-2018-0053
3 Insights on
- High evidence
Lactobacillus reuteri V3401 Reduces Inflammatory Biomarkers and Modifies the Gastrointestinal Microbiome in Adults with Metabolic Syndrome: The PROSIR Study
- 2019-07-31
- RCT · n = 53
- Nutrients 11(8)
- - C. Tenorio-Jiménez
  - M. Martínez-Ramírez
  - I. Del Castillo-Codes
  - C. Arraiza-Irigoyen
  - M. Tercero-Lozano
  - José Camacho
  - N. Chueca
  - Federico García
  - J. Olza
  - J. Plaza-Díaz
  - L. Fontana
  - M. Olivares
  - Á. Gil
  - C. Gómez-Llorente
- PubMed: 31370223
- DOI: 10.3390/nu11081761
7 Insights on
- High evidence
Gut Dysbiosis and the Intestinal Microbiome: Streptococcus thermophilus a Key Probiotic for Reducing Uremia
- 2019-07-31
- Review
- Microorganisms 7(8)
- - L. Vitetta
  - H. Llewellyn
  - D. Oldfield
- PubMed: 31370220
- DOI: 10.3390/microorganisms7080228
2 Insights on
- Reduced Uremic Toxins Levels
- Reduced Mucosal Pro-Inflammatory Activity
- Moderate evidence
- Rigorous Journal
Lactobacilli Isolated From Wild Boar (Sus scrofa) Antagonize Mycobacterium bovis Bacille Calmette-Guerin (BCG) in a Species-Dependent Manner.
- 2019-07-30
- Frontiers in microbiology 10
- - Maria Bravo
  - Theo Combes
  - Fernando O Martinez
  - Rosario Cerrato
  - Joaquín Rey
  - Waldo Garcia-Jimenez
  - Pedro Fernandez-Llario
  - David Risco
  - Jorge Gutierrez-Merino
- PubMed: 31417502
- DOI: 10.3389/fmicb.2019.01663
4 Insights on
- Low evidence
Modulatory effect of Lactobacillus acidophilus KLDS 1.0738 on intestinal short‐chain fatty acids metabolism and GPR41/43 expression in β‐lactoglobulin–sensitized mice
- 2019-07-29
- Clinical Trial
- Microbiology and Immunology 63(8)
- - Jun-Juan Wang
  - Qi-Min Zhang
  - Wei-wei Ni
  - Xin Zhang
  - Ying Li
  - Ai-Li Li
  - P. Du
  - Chun Li
  - Su-Su Yu
- PubMed: 31218724
- DOI: 10.1111/1348-0421.12723
4 Insights on
- Low evidence
- Animal Study
Lactobacillus plantarum L‐137 upregulates hyaluronic acid production in epidermal cells and fibroblasts in mice
- 2019-07-29
- Clinical Trial
- Microbiology and Immunology 63(9)
- - Hiroko Nakai
  - Y. Hirose
  - S. Murosaki
  - Y. Yoshikai
- PubMed: 31273816
- DOI: 10.1111/1348-0421.12725
5 Insights on
- Low evidence
- Animal Study
Update on the treatment of vitamin B6 dependent epilepsies.
- 2019-07-29
- Review
- Expert review of neurotherapeutics 19(11)
- - Mario Mastrangelo
  - Serena Cesario
- PubMed: 31340680
- DOI: 10.1080/14737175.2019.1648212
1 Insight on
- Reduced Seizure Frequency
- Low evidence
Effects of Streptococcus salivarius K12 with nystatin on oral candidiasis - RCT.
- 2019-07-26
- RCT · n = 56
- Oral Diseases 25(6)
- - Li-Jie Hu
  - Qinghua Mao
  - Peiru Zhou
  - Xin Lv
  - H. Hua
  - Zhimin Yan
- PubMed: 31177581
- DOI: 10.1111/odi.13142
5 Insights on
- High evidence
Probiotic Properties of Lactobacillus paracasei subsp. paracasei L1 and Its Growth Performance-Promotion in Chicken by Improving the Intestinal Microflora
- 2019-07-25
- RCT · n = 240
- Frontiers in Physiology 10
- - Yunhe Xu
  - Yuan Tian
  - Yunfang Cao
  - Jianguo Li
  - Haonan Guo
  - Yuhong Su
  - Yu-min Tian
  - Cheng Wang
  - Tianqi Wang
  - Lili Zhang
- PubMed: 31404251
- DOI: 10.3389/fphys.2019.00937
16 Insights on
- Low evidence
- Animal Study
Exploring the Science behind Bifidobacterium breve M-16V in Infant Health
- 2019-07-25
- Nutrients 11(8)
- - C. B. Wong
  - N. Iwabuchi
  - J. Xiao
- PubMed: 31349739
- DOI: 10.3390/nu11081724
3 Insights on
- Moderate evidence
A randomized double-blind placebo-controlled trial of probiotics in post-surgical colorectal cancer
- 2019-07-24
- RCT · n = 52
- BMC Gastroenterology 19(1)
- - Liyana Zaharuddin
  - N. Mokhtar
  - K. M. Muhammad Nawawi
  - R. R. Raja Ali
- PubMed: 31340751
- DOI: 10.1186/s12876-019-1047-4
2 Insights on
- Reduced Pro-inflammatory Cytokine Levels
- Unchanged IFN-γ Levels
- High evidence
- Highly Cited
- Rigorous Journal
The influence of probiotics on genital high-risk human papilloma virus clearance and quality of cervical smear: a randomized placebo-controlled trial.
- 2019-07-24
- RCT · n = 121
- BMC women's health 19(1)
- - Yu-Che Ou
  - Hung-Chun Fu
  - Chih-Wen Tseng
  - Chen-Hsuan Wu
  - Ching-Chou Tsai
  - Hao Lin
- PubMed: 31340789
- DOI: 10.1186/s12905-019-0798-y
2 Insights on
- Reduced Genital HR-HPV Infection
- Improved Cervical Smear Quality
- High evidence
- Large Human Trial
Bacillus clausii as adjunctive treatment for acute community-acquired diarrhea among Filipino children: a large-scale, multicenter, open-label study (CODDLE)
- 2019-07-23
- Clinical Trial · n = 3,178
- Tropical Diseases, Travel Medicine and Vaccines 5(1)
- - Jo-Anne A de Castro
  - Mary Jean V. Guno
  - M. Perez
- PubMed: 31367461
- DOI: 10.1186/s40794-019-0089-5
10 Insights on
- High evidence
- Large Human Trial
- Rigorous Journal
Daily Intake of Fermented Milk Containing Lactobacillus casei Shirota (Lcs) Modulates Systemic and Upper Airways Immune/Inflammatory Responses in Marathon Runners
- 2019-07-22
- RCT · n = 42
- Nutrients 11(7)
- - M. Vaisberg
  - V. Paixão
  - E. Almeida
  - Juliana M. B. Santos
  - R. Foster
  - Marcelo N. Rossi
  - T. Pithon-Curi
  - R. Gorjão
  - C. M. Momesso
  - M. Andrade
  - J. R. Araújo
  - M. C. Garcia
  - M. Cohen
  - E. C. Perez
  - A. Santos-Dias
  - R. Vieira
  - A. Bachi
- PubMed: 31336570
- DOI: 10.3390/nu11071678
6 Insights on
- High evidence
Is Bacillus coagulans supplementation plus low FODMAP diet superior to low FODMAP diet in irritable bowel syndrome management?
- 2019-07-20
- RCT
- European journal of nutrition 59(5)
- - Khadijeh Abhari
  - Saeede Saadati
  - Fatemeh Hosseini-Oskouiee
  - Zahra Yari
  - Hedayat Hosseini
  - Golbon Sohrab
  - Ehsan Hejazi
  - Shahram Agah
  - Amir Sadeghi
  - Azita Hekmatdoost
- PubMed: 31327047
- DOI: 10.1007/s00394-019-02060-y
7 Insights on
- High evidence
- Rigorous Journal
N-Acetyl Cysteine Is Associated With Dopaminergic Improvement in Parkinson's Disease.
- 2019-07-17
- RCT
- Clinical pharmacology and therapeutics 106(4)
- - Daniel A Monti
  - George Zabrecky
  - Daniel Kremens
  - Tsao-Wei Liang
  - Nancy A Wintering
  - Anthony J Bazzan
  - Li Zhong
  - Brendan K Bowens
  - Inna Chervoneva
  - Charles Intenzo
  - Andrew B Newberg
- PubMed: 31206613
- DOI: 10.1002/cpt.1548
4 Insights on
- High evidence
- Highly Cited
Isolation and Characterization of Lactobacillus spp. from Kefir Samples in Malaysia
- 2019-07-17
- Molecules 24(14)
- - Noorshafadzilah Talib
  - N. Mohamad
  - S. Yeap
  - Yazmin Hussin
  - Muhammad Nazirul Mubin Aziz
  - M. J. Masarudin
  - S. A. Sharifuddin
  - Y. W. Hui
  - C. Ho
  - N. Alitheen
- PubMed: 31319614
- DOI: 10.3390/molecules24142606
5 Insights on
- Low evidence
Lactobacillus reuteri DSM 17938 Probiotics May Increase CC-Chemokine Receptor 7 Expression in Infants Treated With for Colic
- 2019-07-16
- RCT · n = 50
- Frontiers in Pediatrics 7
- - F. Savino
  - I. Galliano
  - Andrea Savino
  - V. Daprá
  - P. Montanari
  - Cristina Calvi
  - M. Bergallo
- PubMed: 31380326
- DOI: 10.3389/fped.2019.00292
4 Insights on
- High evidence
Effects of Clostridium butyricum and Enterococcus faecalis on growth performance, intestinal structure and inflammation in lipopolysaccharide-challenged weaned piglets.
- 2019-07-16
- RCT
- Journal of Animal Science 97(10)
- - Kangli Wang
  - Guangyong Chen
  - G. Cao
  - Yinglei Xu
  - Yongxia Wang
  - Caimei Yang
- PubMed: 31310662
- DOI: 10.1093/jas/skz235
5 Insights on
- High evidence
- Rigorous Journal