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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Turmeric and chicory seed have beneficial effects on obesity markers and lipid profile in non-alcoholic fatty liver disease (NAFLD).
- 2019-11
- RCT · n = 92
- International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 89(5-6)
- - Aida Ghaffari
  - Maryam Rafraf
  - Roya Navekar
  - Bita Sepehri
  - Mohammad Asghari-Jafarabadi
  - Seyyed-Mostafa Ghavami
- PubMed: 31017556
- DOI: 10.1024/0300-9831/a000568
6 Insights on
- High evidence
Effect of dietary supplementation of Bacillus subtilis DSM29784 on hen performance, egg quality indices, and apparent retention of dietary components in laying hens from 19 to 48 weeks of age.
- 2019-11
- RCT · n = 336
- Poultry Science 98(11)
- - M. Neijat
  - R. Shirley
  - J. Barton
  - P. Thiery
  - A. Welsher
  - E. Kiarie
- PubMed: 31222316
- DOI: 10.3382/ps/pez324
6 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
In vitro inhibitory activity of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 alone or in combination against bacterial and Candida reference strains and clinical isolates
- 2019-11
- Heliyon 5(11)
- - Rosanna Inturri
  - L. Trovato
  - G. Volti
  - S. Oliveri
  - G. Blandino
- PubMed: 31799467
- DOI: 10.1016/j.heliyon.2019.e02891
1 Insight on
- Reduced Pathogenic Microorganism Activity
- Low evidence
Effects of Lactococcus lactis from Cyprinus carpio L. as probiotics on growth performance, innate immune response and disease resistance against Aeromonas hydrophila.
- 2019-10
- Clinical Trial
- Fish & Shellfish Immunology 93
- - Junchang Feng
  - Xulu Chang
  - Yuru Zhang
  - Xiao Yan
  - Jianxin Zhang
  - G. Nie
- PubMed: 31302283
- DOI: 10.1016/j.fsi.2019.07.028
9 Insights on
- Low evidence
- Animal Study
Benign prostate hyperplasia and nutrition.
- 2019-10
- Systematic Review
- Clinical nutrition ESPEN 33
- - K Das
  - N Buchholz
- PubMed: 31451276
- DOI: 10.1016/j.clnesp.2019.07.015
1 Insight on
- Improved Benign Prostatic Hyperplasia Symptoms
- High evidence
Qualification of tropical fruit-derived Lactobacillus plantarum strains as potential probiotics acting on blood glucose and total cholesterol levels in Wistar rats.
- 2019-10
- Clinical Trial
- Food Research International 124
- - W. K. A. da Costa
  - Larissa Ramalho Brandão
  - M. E. Martino
  - Estefânia F Garcia
  - A. F. Alves
  - E. L. de Souza
  - Jailane de Souza Aquino
  - M. Saarela
  - F. Leulier
  - H. Vidal
  - M. Magnani
- PubMed: 31466629
- DOI: 10.1016/J.FOODRES.2018.08.035
13 Insights on
- Low evidence
- Animal Study
Bacillus amyloliquefaciens CECT 5940 alone or in combination with antibiotic growth promoters improves performance in broilers under enteric pathogen challenge
- 2019-10
- RCT · n = 1,530
- Poultry Science 98(10)
- - Marllon José Karpeggiane de Oliveira
  - N. Sakomura
  - Juliano Cesar de Paula Dorigam
  - K. Doranalli
  - L. Soares
  - G. S. Viana
- PubMed: 31002111
- DOI: 10.3382/ps/pez223
3 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Probiotic Lactobacillus plantarum P8 alleviated stress and anxiety while enhancing memory and cognition in stressed adults: A randomised, double-blind, placebo-controlled study.
- 2019-10
- RCT · n = 103
- Clinical Nutrition 38(5)
- - L. Lew
  - Y. Hor
  - N. A. A. Yusoff
  - S. Choi
  - M. Yusoff
  - N. S. Roslan
  - Anisa Ahmad
  - J. A. Mohammad
  - M. F. I. L. Abdullah
  - Norzila Zakaria
  - N. Wahid
  - Zhihong Sun
  - L. Kwok
  - Heping Zhang
  - M. Liong
- PubMed: 30266270
- DOI: 10.1016/j.clnu.2018.09.010
10 Insights on
- High evidence
- Highly Cited
Lack of Efficacy of Lactobacillus reuteri DSM 17938 for the Treatment of Acute Gastroenteritis: A Randomized Controlled Trial.
- 2019-10
- RCT · n = 100
- Pediatric Infectious Disease Journal 38(10)
- - H. Szymański
  - H. Szajewska
- PubMed: 31033909
- DOI: 10.1097/INF.0000000000002355
3 Insights on
- High evidence
Correlation of changes in HIF-1α and p53 expressions with vitamin B3 deficiency in skin cancer patients.
- 2019-10
- RCT
- Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 154(5)
- - Ting Liu
  - Hao Yang
  - Yunzhu Mou
  - Hao Zhang
- PubMed: 29064206
- DOI: 10.23736/s0392-0488.17.05775-3
4 Insights on
- High evidence
Evaluation of the potential probiotic Bacillus subtilis isolated from two ancient sturgeons on growth performance, serum immunity and disease resistance of Acipenser dabryanus.
- 2019-10
- Fish & Shellfish Immunology 93
- - Jun Di
  - Zhipeng Chu
  - Shuhuan Zhang
  - Jun Huang
  - H. Du
  - Q. Wei
- PubMed: 31419532
- DOI: 10.1016/j.fsi.2019.08.020
9 Insights on
- Low evidence
Effects of probiotics Lactobacillus plantarum 16 and Paenibacillus polymyxa 10 on intestinal barrier function, antioxidative capacity, apoptosis, immune response, and biochemical parameters in broilers.
- 2019-10
- RCT · n = 540
- Poultry Science 98(10)
- - Yan-ping Wu
  - Baikui Wang
  - Zhonghua Zeng
  - Rongrong Liu
  - L. Tang
  - L. Gong
  - Wei-fen Li
- PubMed: 31064013
- DOI: 10.3382/ps/pez226
8 Insights on
- Low evidence
- Highly Cited
- Rigorous Journal
- Animal Study
Anti-tumor potential of cell free culture supernatant of Lactobacillus rhamnosus strains isolated from human breast milk.
- 2019-09
- Food Research International 123
- - M. R. Riaz Rajoka
  - Haobin Zhao
  - H. Mehwish
  - Nan Li
  - Yao Lu
  - Ziyang Lian
  - D. Shao
  - M. Jin
  - Qi Li
  - Liqing Zhao
  - Junling Shi
- PubMed: 31284979
- DOI: 10.1016/J.FOODRES.2019.05.002
4 Insights on
- Low evidence
Addition of oat bran reduces HDL-C and does not potentialize effect of a low-calorie diet on remission of metabolic syndrome: A pragmatic, randomized, controlled, open-label nutritional trial.
- 2019-09
- RCT · n = 83
- Nutrition (Burbank, Los Angeles County, Calif.) 65
- - Leila Sicupira Carneiro de Souza Leão
  - Luana Azevedo de Aquino
  - Juliana Furtado Dias
  - Rosalina Jorge Koifman
- PubMed: 31082790
- DOI: 10.1016/j.nut.2019.03.007
9 Insights on
- High evidence
Bifidobacterium breve Bif195 Protects Against Small-intestinal Damage Caused by Acetylsalicylic Acid in Healthy Volunteers.
- 2019-09
- RCT · n = 75
- Gastroenterology 157(3)
- - Brynjulf Mortensen
  - C. Murphy
  - J. O’Grady
  - M. Lucey
  - G. Elsafi
  - L. Barry
  - V. Westphal
  - A. Wellejus
  - O. Lukjancenko
  - A. Eklund
  - H. Nielsen
  - Adam Baker
  - A. Damholt
  - J. V. H. van Hylckama Vlieg
  - F. Shanahan
  - M. Buckley
- PubMed: 31095949
- DOI: 10.1053/j.gastro.2019.05.008
10 Insights on
- High evidence
Surface-layer protein from Lactobacillus acidophilus NCFM attenuates tumor necrosis factor-α-induced intestinal barrier dysfunction and inflammation.
- 2019-09
- International Journal of Biological Macromolecules 136
- - Huifang Wang
  - Qiuxiang Zhang
  - Yuhan Niu
  - Xin Zhang
  - Rongrong Lu
- PubMed: 31185242
- DOI: 10.1016/j.ijbiomac.2019.06.041
3 Insights on
- Low evidence
"Physicochemical, immunomodulatory and safety aspects of milks fermented with Lactobacillus paracasei isolated from kefir".
- 2019-09
- Food Research International 123
- - A. Bengoa
  - Carolina Iraporda
  - L. Acurcio
  - S. H. de Cicco Sandes
  - Karen Costa
  - Gabriele Moreira Guimarães
  - R. M. Esteves Arantes
  - E. Neumann
  - Á. Cantini Nunes
  - J. R. Nicoli
  - G. L. Garrote
  - A. Abraham
- PubMed: 31284997
- DOI: 10.1016/J.FOODRES.2019.04.041
5 Insights on
- Low evidence
A single-centre investigator-blinded randomised parallel group clinical trial to investigate the effect of probiotic strains Streptococcus salivarius M18 and Lactobacillus acidophilus on gingival health of paediatric patients undergoing treatment with fixed orthodontic appliances: study protocol
- 2019-09
- RCT · n = 50
- BMJ Open 9(9)
- - E. Kaklamanos
  - Rania Nassar
  - S. Kalfas
  - M. Al Halabi
  - M. Kowash
  - Haifa Hannawi
  - I. Hussein
  - A. Salami
  - A. Hassan
  - A. Senok
- PubMed: 31501124
- DOI: 10.1136/bmjopen-2019-030638
4 Insights on
- High evidence
- Rigorous Journal
BACILLUS CLAUSII SEPTICEMIA IN A PEDIATRIC PATIENT AFTER TREATMENT WITH PROBIOTICS.
- 2019-09
- Case Report · n = 1
- Pediatric Infectious Disease Journal 38(9)
- - S. Joshi
  - S. Udani
  - Supratim Sen
  - S. Kirolikar
  - A. Shetty
- PubMed: 31033906
- DOI: 10.1097/INF.0000000000002350
4 Insights on
- Low evidence
Partial characterization of a levan type exopolysaccharide (EPS) produced by Leuconostoc mesenteroides showing immunostimulatory and antioxidant activities.
- 2019-09
- International Journal of Biological Macromolecules 136
- - O. Taylan
  - M. Yılmaz
  - E. Dertli
- PubMed: 31201910
- DOI: 10.1016/j.ijbiomac.2019.06.078
2 Insights on
- Reduced Inflammatory Response
- Increased Antioxidant Capacity
- Low evidence
- Highly Cited
The Effect of 2 Weeks of Inactivated Probiotic Bacillus coagulans on Endocrine, Inflammatory, and Performance Responses During Self-Defense Training in Soldiers.
- 2019-09
- RCT · n = 16
- Journal of Strength and Conditioning Research 33(9)
- - J. Hoffman
  - Mattan W. Hoffman
  - H. Zelicha
  - Y. Gepner
  - D. Willoughby
  - Uri Feinstein
  - I. Ostfeld
- PubMed: 31306390
- DOI: 10.1519/JSC.0000000000003265
10 Insights on
- High evidence
Safety of Lactobacillus reuteri DSM 17938 in Healthy Children 2 to 5 Years of Age.
- 2019-08
- RCT · n = 60
- Pediatric Infectious Disease Journal 38(8)
- - M. Kosek
  - Pablo Peñataro-Yori
  - Maribel Paredes-Olórtegui
  - J. Lefante
  - César Ramal-Asayag
  - Marcelo Zamora-Babilonia
  - Graciela Meza-Sánchez
  - R. Oberhelman
- PubMed: 30531312
- DOI: 10.1097/INF.0000000000002267
4 Insights on
- High evidence
Effect of fermented milk from Lactococcus lactis ssp. cremoris strain JFR1 on Salmonella invasion of intestinal epithelial cells.
- 2019-08
- Journal of Dairy Science 102(8)
- - J. S. Zhang
  - M. Corredig
  - R. Morales-Rayas
  - A. Hassan
  - M. Griffiths
  - G. LaPointe
- PubMed: 31202650
- DOI: 10.3168/jds.2018-15669
4 Insights on
- Low evidence
- Rigorous Journal
Saccharomyces cerevisiae boulardii CNCM I-1079 affects health, growth, and fecal microbiota in milk-fed veal calves.
- 2019-08
- RCT · n = 84
- Journal of Dairy Science 102(8)
- - C. Villot
  - Tao Ma
  - David L. Renaud
  - M. Ghaffari
  - D. Gibson
  - A. Skidmore
  - E. Chevaux
  - L. Guan
  - M. A. Steele
- PubMed: 31155261
- DOI: 10.3168/jds.2018-16149
4 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Nutritional quality of fresh and stored legumes sprouts - Effect of Lactobacillus plantarum 299v enrichment.
- 2019-08
- Food chemistry 288
- - Michal Swieca
  - Urszula Gawlik-Dziki
  - Anna Jakubczyk
  - Justyna Bochnak
  - Małgorzata Sikora
  - Joanna Suliburska
- PubMed: 30902300
- DOI: 10.1016/j.foodchem.2019.02.135
2 Insights on
- Improved Digestibility
- Maintained Nutritional Quality
- Low evidence
Improvement of taste and shelf life of yeasted low-salt bread containing functional sourdoughs using Lactobacillus amylovorus DSM 19280 and Weisella cibaria MG1.
- 2019-08
- International journal of food microbiology 302
- - Markus C E Belz
  - Claudia Axel
  - Elke K Arendt
  - Kieran M Lynch
  - Brid Brosnan
  - Elizabeth M Sheehan
  - Aidan Coffey
  - Emanuele Zannini
- PubMed: 30017109
- DOI: 10.1016/j.ijfoodmicro.2018.07.015
1 Insight on
- Improved Taste Sensation
- Low evidence
Fermented milk containing Lactobacillus paracasei and Glycyrrhiza glabra has a beneficial effect in patients with Helicobacter pylori infection: A randomized, double-blind, placebo-controlled study.
- 2019-08
- RCT · n = 142
- Medicine 98(35)
- - Jin Young Yoon
  - Jae Myung Cha
  - Seong Soo Hong
  - Hyung Kyung Kim
  - Min Seob Kwak
  - Jung Won Jeon
  - Hyun Phil Shin
- PubMed: 31464895
- DOI: 10.1097/md.0000000000016601
5 Insights on
- High evidence
- Large Human Trial
Grapefruit juice prolongs the QT interval of healthy volunteers and patients with long QT syndrome.
- 2019-08
- RCT · n = 10
- Heart rhythm 16(8)
- - Ehud Chorin
  - Aviram Hochstadt
  - Yoav Granot
  - Shafik Khoury
  - Arie Lorin Schwartz
  - Gilad Margolis
  - Rami Barashi
  - Dana Viskin
  - Eihab Ghantous
  - Michael Schnapper
  - Tal Mekori
  - Dana Fourey
  - Milton Ernesto Guevara-Valdivia
  - Manlio F Marquez
  - David Zeltzer
  - Raphael Rosso
  - Sami Viskin
- PubMed: 31075442
- DOI: 10.1016/j.hrthm.2019.04.039
1 Insight on
- Prolonged QT Interval
- High evidence
Safety of Lactobacillus Reuteri DSM 17938 in Healthy Children 2-5 Years of Age.
- 2019-08
- RCT · n = 60
- The Pediatric infectious disease journal 38(8)
- - Margaret N Kosek
  - Pablo Peñataro-Yori
  - Maribel Paredes-Olortegui
  - John Lefante
  - Cesar Ramal-Asayag
  - Marcelo Zamora-Babilonia
  - Graciela Meza-Sanchez
  - Richard A Oberhelman
- PubMed: 30531312
- DOI: 10.1097/inf.0000000000002267
2 Insights on
- Reduced Fever
- Reduced Diarrhea
- High evidence
Clostridium butyricum miyairi 588 has preventive effects on chronic social defeat stress-induced depressive-like behaviour and modulates microglial activation in mice.
- 2019-08
- Clinical Trial
- Biochemical and Biophysical Research Communications 516(2)
- - Tian Tian
  - Bing Xu
  - Yinhua Qin
  - Liping Fan
  - Jian-jun Chen
  - P. Zheng
  - Xue Gong
  - Haiyang Wang
  - M. Bai
  - Juncai Pu
  - Jian Lu
  - W. Zhou
  - L. Zhao
  - Deyu Yang
  - P. Xie
- PubMed: 31227215
- DOI: 10.1016/j.bbrc.2019.06.053
3 Insights on
- Low evidence
- Animal Study