October 2019 Supplement Research Papers

• October 1

  • Bifidobacterial Dialogue With Its Human Host and Consequent Modulation of the Immune System

    • 2019-10-01
    • Frontiers in Immunology 10
    • • Giulia Alessandri
      • M. C. Ossiprandi
      • John Macsharry
      • D. van Sinderen
      • M. Ventura

    • PubMed: 31632412
    • DOI: 10.3389/fimmu.2019.02348

    3 Insights on

    • Enhanced Immune Function
    • Improved Gut Homeostasis
    • Reduced Pathogen Colonization

    • Low evidence
• October 2

  • Nutraceutical treatment and prevention of benign prostatic hyperplasia and prostate cancer.

    • 2019-10-02
    • Review
    • Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica 91(3)
    • • Arrigo F G Cicero
      • Olta Allkanjari
      • Gian Maria Busetto
      • Tommaso Cai
      • Gaetano Larganà
      • Vittorio Magri
      • Gianpaolo Perletti
      • Francesco Saverio Robustelli Della Cuna
      • Giorgio Ivan Russo
      • Kostantinos Stamatiou
      • Alberto Trinchieri
      • Annabella Vitalone

    • PubMed: 31577095
    • DOI: 10.4081/aiua.2019.3.139

    11 Insights on

    • Improved Quality of Life
    • Reduced Prostate Inflammation
    • Improved Symptoms
    • Reduced Pain
    • Improved Lower Urinary Tract Symptoms
    • Reduced Nocturia
    • Reduced Discomfort
    • Improved Benign Prostatic Hyperplasia Symptoms
    • Improved Urinary Flow Measure
    • Improved BPH Symptom Score
    • Improved Urinary Flow

    • Low evidence

  • Efficacy of L-leucine Supplementation Coupled With Resistance Training in Untrained Midlife Women.

    • 2019-10-02
    • RCT
    • Journal of the American College of Nutrition 39(4)
    • • LesLee K Funderburk
      • Kaitlan N Beretich
      • Marcus D Chen
      • Darryn S Willoughby

    • PubMed: 31577520
    • DOI: 10.1080/07315724.2019.1650675

    7 Insights on

    • Reduced Cortisol Levels
    • Increased Estradiol Level
    • Increased Testosterone Level
    • Increased Fat-Free Mass
    • Increased Strength
    • Increased Insulin-like Growth Factor-1 Level
    • Increased Growth Hormone Level

    • High evidence
    • Rigorous Journal
• October 3

  • Development of a Mucoadhesive In Situ Gelling Formulation for the Delivery of Lactobacillus gasseri into Vaginal Cavity

    • 2019-10-03
    • Pharmaceutics 11(10)
    • • B. Vigani
      • Angela Faccendini
      • S. Rossi
      • G. Sandri
      • M. C. Bonferoni
      • P. Grisoli
      • F. Ferrari

    • PubMed: 31623341
    • DOI: 10.3390/pharmaceutics11100511

    1 Insight on

    • Reduced Recurrences of Candidosis

    • Low evidence

  • Synbiotics for prevention of ventilator-associated pneumonia: a probiotics strain-specific network meta-analysis.

    • 2019-10-03
    • Meta-Analysis
    • The Journal of international medical research 47(11)
    • • Qiong-Li Fan
      • Xiu-Mei Yu
      • Quan-Xing Liu
      • Wang Yang
      • Qin Chang
      • Yu-Ping Zhang
      • Yu-Ping Zhang

    • PubMed: 31578896
    • DOI: 10.1177/0300060519876753

    3 Insights on

    • Reduced Hospital Mortality Rate
    • Reduced Ventilator-Associated Pneumonia
    • Reduced Intensive Care Unit Mortality

    • High evidence
• October 4

  • Lactobacillus gasseri Suppresses the Production of Proinflammatory Cytokines in Helicobacter pylori-Infected Macrophages by Inhibiting the Expression of ADAM17

    • 2019-10-04
    • Frontiers in Immunology 10
    • • Hanna G. Gebremariam
      • K. R. Qazi
      • Tanvi Somiah
      • S. Pathak
      • Hong Sjölinder
      • E. Sverremark Ekström
      • A. Jonsson

    • PubMed: 31636639
    • DOI: 10.3389/fimmu.2019.02326

    4 Insights on

    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Proinflammatory Cytokine Production
    • Reduced Inflammation
    • Reduced Expression of ADAM17

    • Low evidence
• October 9

  • Hypnotic Effects of Lactobacillus fermentum PS150TM on Pentobarbital-Induced Sleep in Mice.

    • 2019-10-09
    • Nutrients 11(10)
    • • Alexander Lin
      • Ching-Ting Shih
      • Chin-Lin Huang
      • Chien-Chen Wu
      • Ching-Ting Lin
      • Ying-Chieh Tsai

    • PubMed: 31600934
    • DOI: 10.3390/nu11102409

    2 Insights on

    • Improved Sleep Quality
    • Reduced Circadian Sleep Disturbance

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Propionibacterium freudenreichii CIRM-BIA 129 Osmoadaptation Coupled to Acid-Adaptation Increases Its Viability During Freeze-Drying

    • 2019-10-09
    • Frontiers in Microbiology 10
    • • Floriane Gaucher
      • Koffigan Kponouglo
      • Houem Rabah
      • S. Bonnassie
      • Jordane Ossemond
      • Sandrine Pottier
      • J. Jardin
      • V. Briard-Bion
      • P. Marchand
      • P. Blanc
      • R. Jeantet
      • G. Jan

    • PubMed: 31681198
    • DOI: 10.3389/fmicb.2019.02324

    1 Insight on

    • Improved Immunomodulation

    • Low evidence
• October 11

  • The Effect of Clostridium butyricum on Gut Microbiota, Immune Response and Intestinal Barrier Function During the Development of Necrotic Enteritis in Chickens

    • 2019-10-11
    • Frontiers in Microbiology 10
    • • Ting Huang
      • Xinyu Peng
      • B. Gao
      • Qingying Wei
      • Rong Xiang
      • Minggui Yuan
      • Zhihong Xu

    • PubMed: 31681193
    • DOI: 10.3389/fmicb.2019.02309

    1 Insight on

    • Altered Gastrointestinal Health Post-Infection

    • Low evidence
• October 12

  • Effect of Yeast Fermentate Supplementation on Intestinal Health and Plasma Biochemistry in Heat-Stressed Pekin Ducks.

    • 2019-10-12
    • RCT
    • Animals : an open access journal from MDPI 9(10)
    • • Jill R Nelson
      • Gregory S Archer

    • PubMed: 31614703
    • DOI: 10.3390/ani9100790

    5 Insights on

    • Improved Intestinal Villus Morphology
    • Increased Uric Acid
    • Increased Plasma Phosphorus
    • Increased Plasma GLDH
    • Altered Amino Acid Metabolism

    • High evidence
• October 14

  • Recovery of Lactobacillus casei strain Shirota (LcS) from faeces of healthy Singapore adults after intake of fermented milk.

    • 2019-10-14
    • Beneficial Microbes 10(7)
    • • W. W. T. Khine
      • X. Ang
      • Y. S. Chan
      • W. Q. Lee
      • S. Quek
      • S. H. Tan
      • H. T. A. Teo
      • J. Teo
      • Q. Lau
      • Y.K. Lee

    • PubMed: 31965844
    • DOI: 10.3920/BM2018.0173

    7 Insights on

    • Improved Bowel Movement Frequency
    • Improved Stool Consistency
    • Survived Gastrointestinal Passage
    • Lack of Sustainable Colonization
    • Increased Defecation Frequency
    • Reduced Colonisation of Lactobacillus casei Strain Shirota
    • Changed Stool Consistency

    • Low evidence
• October 15

  • Modulation of T Regulatory and Dendritic Cell Phenotypes Following Ingestion of Bifidobacterium longum, AHCC® and Azithromycin in Healthy Individuals

    • 2019-10-15
    • RCT · n = 40
    • Nutrients 11(10)
    • • A. Chowdhury
      • M. Cámara
      • C. Verma
      • O. Eremin
      • A. Kulkarni
      • D. Lobo

    • PubMed: 31618905
    • DOI: 10.3390/nu11102470

    1 Insight on

    • Increased IFN-γ to IL-4 Ratio

    • High evidence
• October 16

  • Clinical efficacy of Lactobacillus reuteri-containing lozenges in the supportive therapy of generalized periodontitis stage III and IV, grade C: 1-year results of a double-blind randomized placebo-controlled pilot study

    • 2019-10-16
    • RCT · n = 20
    • Clinical Oral Investigations 24(6)
    • • M. G. Grusovin
      • S. Bossini
      • S. Calza
      • V. Cappa
      • G. Garzetti
      • E. Scotti
      • E. Gherlone
      • M. Mensi

    • PubMed: 31620939
    • DOI: 10.1007/s00784-019-03065-x

    5 Insights on

    • Reduced Probing Pocket Depth
    • Improved Probing Depth
    • Reduced Bleeding on Probing (BOP)
    • Improved Probing Attachment Level
    • Improved Periodontal Attachment Level

    • High evidence

  • Daily intake of heat-killed Lactobacillus plantarum L-137 improves inflammation and lipid metabolism in overweight healthy adults: a randomized-controlled trial

    • 2019-10-16
    • RCT · n = 100
    • European Journal of Nutrition 59(6)
    • • Yusuke Tanaka
      • Y. Hirose
      • Yoshihiro Yamamoto
      • Y. Yoshikai
      • S. Murosaki

    • PubMed: 31620886
    • DOI: 10.1007/s00394-019-02112-3

    12 Insights on

    • Reduced Total Cholesterol Levels
    • Improved Immune Response
    • Improved Lipid Metabolism
    • Reduced Inflammation Levels
    • Improved Lipid Profile
    • Reduced Liver Enzyme Levels
    • Improved Immune Cell Function
    • Improved Inflammatory Response
    • Reduced Inflammation
    • Reduced Elevated Liver Enzymes
    • Increased C-Reactive Protein Levels
    • Improved Inflammation Levels

    • High evidence
    • Rigorous Journal
• October 21

  • Evaluation of the safety, tolerance and efficacy of 1-year consumption of infant formula supplemented with Lactobacillus fermentum CECT5716 Lc40 or Bifidobacterium breve CECT7263: a randomized controlled trial

    • 2019-10-21
    • RCT · n = 236
    • BMC Pediatrics 19(1)
    • • José Maldonado
      • Mercedes Gil-Campos
      • J. Maldonado-Lobón
      • M. R. Benavides
      • K. Flores-Rojas
      • R. Jaldo
      • I. J. D. Barco
      • V. Bolívar
      • A. Valero
      • E. Prados
      • I. Peñalver
      • M. Olivares

    • PubMed: 31630683
    • DOI: 10.1186/s12887-019-1753-7

    8 Insights on

    • Reduced Duration of Diarrhea
    • Reduced Diarrhea Incidence
    • Reduced Risk of Crying
    • Reduced Incidence of Severe Diarrhoea
    • Reduced Crying in Infants
    • Reduced Duration of Acute Diarrhoea
    • Reduced Crying
    • Reduced Incidence of Crying

    • High evidence
    • Rigorous Journal
• October 22

  • The Step of Incorporation of Bacillus coagulans GBI-30 6086 Into “requeijão cremoso” Processed Cheese Does Not Affect Metabolic Homeostasis of Rats

    • 2019-10-22
    • RCT · n = 20
    • Frontiers in Microbiology 10
    • • Mariana B. Soares
      • V. A. Santos-Junior
      • E. T. Tavares Filho
      • P. Lollo
      • P. Morato
      • J. Amaya-Farfan
      • Eliene Pereira
      • C. Balthazar
      • A. G. Cruz
      • R. C. Martinez
      • A. Sant’Ana

    • PubMed: 31695686
    • DOI: 10.3389/fmicb.2019.02332

    1 Insight on

    • Maintained Metabolic Homeostasis

    • Low evidence
    • Animal Study
• October 28

  • Anti-obesity effect of Lactobacillus rhamnosus LS-8 and Lactobacillus crustorum MN047 on high-fat and high-fructose diet mice base on inflammatory response alleviation and gut microbiota regulation

    • 2019-10-28
    • Clinical Trial
    • European Journal of Nutrition 59(6)
    • • Tao Wang
      • Hong Yan
      • Yingying Lu
      • Xin Li
      • Xin Wang
      • Y. Shan
      • Yanglei Yi
      • Bianfang Liu
      • Yuan Zhou
      • Xin Lü

    • PubMed: 31659451
    • DOI: 10.1007/s00394-019-02117-y

    5 Insights on

    • Improved Insulin Sensitivity
    • Reduced Body Weight
    • Reduced Inflammatory Response
    • Normalized Lipid Metabolism
    • Increased SCFA Levels

    • Low evidence
    • Rigorous Journal
    • Animal Study
• Undated – 8 supplement studies

  • Probiotic Lactobacillus plantarum P8 alleviated stress and anxiety while enhancing memory and cognition in stressed adults: A randomised, double-blind, placebo-controlled study.

    • 2019-10
    • RCT · n = 103
    • Clinical Nutrition 38(5)
    • • L. Lew
      • Y. Hor
      • N. A. A. Yusoff
      • S. Choi
      • M. Yusoff
      • N. S. Roslan
      • Anisa Ahmad
      • J. A. Mohammad
      • M. F. I. L. Abdullah
      • Norzila Zakaria
      • N. Wahid
      • Zhihong Sun
      • L. Kwok
      • Heping Zhang
      • M. Liong

    • PubMed: 30266270
    • DOI: 10.1016/j.clnu.2018.09.010

    10 Insights on

    • Reduced Pro-Inflammatory Cytokines
    • Reduced Anxiety Levels
    • Reduced Inflammation Levels
    • Reduced Subjective Stress Levels
    • Reduced Pro-inflammatory Cytokine Levels
    • Improved Total DASS-42 Score
    • Improved Psychological Well-being
    • Reduced Stress Levels
    • Improved Social Emotional Cognition
    • Reduced Total Score on Depression Anxiety Stress Scales (DASS-42)

    • High evidence
    • Highly Cited

  • Effects of probiotics Lactobacillus plantarum 16 and Paenibacillus polymyxa 10 on intestinal barrier function, antioxidative capacity, apoptosis, immune response, and biochemical parameters in broilers.

    • 2019-10
    • RCT · n = 540
    • Poultry Science 98(10)
    • • Yan-ping Wu
      • Baikui Wang
      • Zhonghua Zeng
      • Rongrong Liu
      • L. Tang
      • L. Gong
      • Wei-fen Li

    • PubMed: 31064013
    • DOI: 10.3382/ps/pez226

    8 Insights on

    • Improved Intestinal Barrier Function
    • Improved Immune Response
    • Reduced Hepatic Oxidative Stress
    • Reduced Apoptosis of Jejunal Mucosal Cells
    • Improved Biochemical Parameters
    • Reduced Cell Apoptosis
    • Reduced Biochemical Marker Levels
    • Improved Antioxidative Capacity

    • Low evidence
    • Highly Cited
    • Rigorous Journal
    • Animal Study

  • Effects of Lactococcus lactis from Cyprinus carpio L. as probiotics on growth performance, innate immune response and disease resistance against Aeromonas hydrophila.

    • 2019-10
    • Clinical Trial
    • Fish & Shellfish Immunology 93
    • • Junchang Feng
      • Xulu Chang
      • Yuru Zhang
      • Xiao Yan
      • Jianxin Zhang
      • G. Nie

    • PubMed: 31302283
    • DOI: 10.1016/j.fsi.2019.07.028

    9 Insights on

    • Improved Growth Performance
    • Enhanced Disease Resistance
    • Improved Cell Survival Rates
    • Enhanced Innate Immune Function
    • Enhanced Anti-inflammatory Response
    • Increased Anti-inflammatory Cytokines
    • Increased Plasma Anti-inflammatory Cytokine Levels
    • Enhanced Innate Immune Response
    • Enhanced Pro-Inflammatory Cytokine Response

    • Low evidence
    • Animal Study

  • Evaluation of the potential probiotic Bacillus subtilis isolated from two ancient sturgeons on growth performance, serum immunity and disease resistance of Acipenser dabryanus.

    • 2019-10
    • Fish & Shellfish Immunology 93
    • • Jun Di
      • Zhipeng Chu
      • Shuhuan Zhang
      • Jun Huang
      • H. Du
      • Q. Wei

    • PubMed: 31419532
    • DOI: 10.1016/j.fsi.2019.08.020

    9 Insights on

    • Increased Serum Lysozyme Activity
    • Improved Survival Rate
    • Reduced Hepatic Oxidative Stress
    • Elevated Antioxidant Levels
    • Enhanced Disease Resistance
    • Reduced Serum Malondialdehyde Levels
    • Enhanced Antioxidant Activity
    • Increased Serum Immunoglobulins
    • Improved Serum Immunity

    • Low evidence

  • Benign prostate hyperplasia and nutrition.

    • 2019-10
    • Systematic Review
    • Clinical nutrition ESPEN 33
    • • K Das
      • N Buchholz

    • PubMed: 31451276
    • DOI: 10.1016/j.clnesp.2019.07.015

    1 Insight on

    • Improved Benign Prostatic Hyperplasia Symptom

    • High evidence

  • Bacillus amyloliquefaciens CECT 5940 alone or in combination with antibiotic growth promoters improves performance in broilers under enteric pathogen challenge

    • 2019-10
    • RCT · n = 1,530
    • Poultry Science 98(10)
    • • Marllon José Karpeggiane de Oliveira
      • N. Sakomura
      • Juliano Cesar de Paula Dorigam
      • K. Doranalli
      • L. Soares
      • G. S. Viana

    • PubMed: 31002111
    • DOI: 10.3382/ps/pez223

    3 Insights on

    • Reduced Clostridium Perfringens Numbers
    • Reduced Incidence of Footpad Lesions
    • Maintained Gut Health

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Lack of Efficacy of Lactobacillus reuteri DSM 17938 for the Treatment of Acute Gastroenteritis: A Randomized Controlled Trial.

    • 2019-10
    • RCT · n = 100
    • Pediatric Infectious Disease Journal 38(10)
    • • H. Szymański
      • H. Szajewska

    • PubMed: 31033909
    • DOI: 10.1097/INF.0000000000002355

    4 Insights on

    • Reduced Duration of Diarrhea
    • Reduced Hospitalization Duration
    • Reduced Diarrhea Rate
    • Reduced Duration of Hospitalization

    • High evidence

  • Qualification of tropical fruit-derived Lactobacillus plantarum strains as potential probiotics acting on blood glucose and total cholesterol levels in Wistar rats.

    • 2019-10
    • Clinical Trial
    • Food Research International 124
    • • W. K. A. da Costa
      • Larissa Ramalho Brandão
      • M. E. Martino
      • Estefânia F Garcia
      • A. F. Alves
      • E. L. de Souza
      • Jailane de Souza Aquino
      • M. Saarela
      • F. Leulier
      • H. Vidal
      • M. Magnani

    • PubMed: 31466629
    • DOI: 10.1016/J.FOODRES.2018.08.035

    13 Insights on

    • Reduced Total Cholesterol Levels
    • No Adverse Effects on Body Weight or Food Intake
    • Improved Blood Glucose Levels
    • Safety of Consumption
    • Absence of Bacterial Translocation to Liver or Spleen
    • Increased Safety of Probiotic Use
    • Increased Intestinal Retention Safety
    • No Adverse Effects in Rats
    • No Adverse Effects on Food Intake
    • No Adverse Effect on Food Intake or Body Measurements
    • No Metastasis to Other Organs
    • Unchanged Food Intake
    • No Adverse Morphometric Parameter Effects

    • Low evidence
    • Animal Study