June 2020 Supplement Research Papers

• June 3

  • Proteome and microbiota analysis highlight Lactobacillus plantarum TWK10 supplementation improves energy metabolism and exercise performance in mice

    • 2020-06-03
    • RCT · n = 8
    • Food Science & Nutrition 8(7)
    • • Yi-Ming Chen
      • C. Liao
      • Yen-Chun Huang
      • Ming-Yi Chen
      • Chi-Chang Huang
      • Wen-Chyuan Chen
      • Yen-Shuo Chiu

    • PubMed: 32724615
    • DOI: 10.1002/fsn3.1635

    2 Insights on

    • Improved Endurance Performance
    • Increased Lipid Oxidation

    • Low evidence
    • Animal Study
• June 4

  • Saccharomyces boulardii: What Makes It Tick as Successful Probiotic?

    • 2020-06-04
    • Journal of Fungi 6(2)
    • • Pedro Pais
      • Vanda Almeida
      • M. Yilmaz
      • Miguel C. Teixeira

    • PubMed: 32512834
    • DOI: 10.3390/jof6020078

    5 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Pathogenic Load
    • Modulated Immune Response
    • Increased Production of Antimicrobial Peptides
    • Enhanced Trophic Effects

    • Low evidence
    • Highly Cited
• June 5

  • Lactobacillus rhamnosus GG (ATCC 53103) for the Management of Infantile Colic: A Randomized Controlled Trial

    • 2020-06-05
    • RCT · n = 45
    • Nutrients 12(6)
    • • F. Savino
      • P. Montanari
      • I. Galliano
      • V. Daprá
      • M. Bergallo

    • PubMed: 32517123
    • DOI: 10.3390/nu12061693

    11 Insights on

    • Increased Fecal Lactobacilli
    • Reduced Crying Duration
    • Reduced Faecal Calprotectin
    • Increased Total Bacterial Load
    • Increased Total Bacterial Count
    • Increased Lactobacilli Levels
    • Increased Lactobacillus Levels
    • Increased Total Bacterial Abundance
    • Reduced Crying in Infants
    • Increased Total Fecal Bacterial Counts
    • Reduced Fecal Calprotectin Levels

    • High evidence

  • Vital members in the gut microbiotas altered by two probiotic Bifidobacterium strains against liver damage in rats.

    • 2020-06-05
    • BMC microbiology 20(1)
    • • Hua Zha
      • Dai-Qiong Fang
      • Aimee van der Reis
      • Kevin Chang
      • Li-Ya Yang
      • Jiao-Jiao Xie
      • Ding Shi
      • Qiao-Mai Xu
      • Ya-Ting Li
      • Lan-Juan Li

    • PubMed: 32503418
    • DOI: 10.1186/s12866-020-01827-2

    2 Insights on

    • Improved Health Status
    • Improved Acute Liver Injury

    • Low evidence
    • Animal Study
• June 8

  • In Vitro Effects of Live and Heat-Inactivated Bifidobacterium animalis Subsp. Lactis, BB-12 and Lactobacillus rhamnosus GG on Caco-2 Cells

    • 2020-06-08
    • Nutrients 12(6)
    • • Vivian Castro-Herrera
      • C. Rasmussen
      • A. Wellejus
      • E. Miles
      • P. Calder

    • PubMed: 32521765
    • DOI: 10.3390/nu12061719

    4 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Pro-Inflammatory Mediator Production
    • Improved Epithelial Barrier Integrity
    • Reduced Inflammatory Response to Inflammatory Stimulus

    • Moderate evidence

  • The Effect of Probiotics and Synbiotics on Risk Factors Associated with Cardiometabolic Diseases in Healthy People-A Systematic Review and Meta-Analysis with Meta-Regression of Randomized Controlled Trials.

    • 2020-06-08
    • Review
    • Journal of clinical medicine 9(6)
    • • Karolina Skonieczna-Żydecka
      • Karolina Kaźmierczak-Siedlecka
      • Mariusz Kaczmarczyk
      • Joanna Śliwa-Dominiak
      • Dominika Maciejewska
      • Katarzyna Janda
      • Ewa Stachowska
      • Beata Łoniewska
      • Damian Malinowski
      • Krzysztof Borecki
      • Wojciech Marlicz
      • Igor Łoniewski

    • PubMed: 32521799
    • DOI: 10.3390/jcm9061788

    3 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Total Cholesterol

    • Low evidence
• June 9

  • The protective effect of Bifidobacterium bifidum G9-1 against mucus degradation by Akkermansia muciniphila following small intestine injury caused by a proton pump inhibitor and aspirin

    • 2020-06-09
    • Clinical Trial
    • Gut Microbes 11(5)
    • • Tsutomu Yoshihara
      • Yosuke Oikawa
      • Takayuki Kato
      • Takaomi Kessoku
      • Takashi Kobayashi
      • S. Kato
      • Noboru Misawa
      • K. Ashikari
      • A. Fuyuki
      • H. Ohkubo
      • T. Higurashi
      • Y. Tateishi
      • Yoshiki Tanaka
      • Shunji Nakajima
      • H. Ohno
      • K. Wada
      • A. Nakajima

    • PubMed: 32515658
    • DOI: 10.1080/19490976.2020.1758290

    2 Insights on

    • Restored Goblet Cell Count
    • Reduced Mucus Layer Thinning

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Evaluation of Probiotics for Warfighter Health and Performance.

    • 2020-06-09
    • Review
    • Frontiers in nutrition 7
    • • Richard T Agans
      • Grace E Giles
      • Michael S Goodson
      • J Philip Karl
      • Samantha Leyh
      • Karen L Mumy
      • Kenneth Racicot
      • Jason W Soares

    • PubMed: 32582752
    • DOI: 10.3389/fnut.2020.00070

    4 Insights on

    • Improved Physical Performance
    • No Human Health Outcome Reported
    • Improved Physical and Cognitive Performance
    • Improved Physical and Psychological Performance

    • Low evidence

  • The Lactobacillus brevis 47 f Strain Protects the Murine Intestine from Enteropathy Induced by 5-Fluorouracil

    • 2020-06-09
    • Clinical Trial
    • Microorganisms 8(6)
    • • M. Marsova
      • M. Odorskaya
      • M. Novichkova
      • V. Polyakova
      • S. Abilev
      • E. Kalinina
      • A. Shtil
      • E. Poluektova
      • V. Danilenko

    • PubMed: 32527057
    • DOI: 10.3390/microorganisms8060876

    13 Insights on

    • Reduced Hepatic Oxidative Stress
    • Reduced Small-Intestinal Damage
    • Reduced Oxidative Stress
    • Reduced Intestinal Damage
    • Reduced Lipid Peroxidation
    • Reduced Drug-Induced Intestinal Damage
    • Partial Restoration of Intestinal Cell Proliferation
    • Reduced Drug-Induced Enteropathy
    • Reduced Enteropathy
    • Improved Intestinal Cell Proliferation
    • Improved Proliferative Capacity of Intestinal Cells
    • Protected Intestinal Health
    • Reduced Severity of Chemotherapy-Induced Enteropathy

    • Low evidence
    • Rigorous Journal
    • Animal Study
• June 10

  • Survival and Germination of Bacillus clausii UBBC07 Spores in in vitro Human Gastrointestinal Tract Simulation Model and Evaluation of Clausin Production

    • 2020-06-10
    • Frontiers in Microbiology 11
    • • J. Ahire
      • M. Kashikar
      • R. Madempudi

    • PubMed: 32733389
    • DOI: 10.3389/fmicb.2020.01010

    2 Insights on

    • Reduced Diarrhea Incidence
    • Reduced Diarrhea Symptoms

    • Low evidence
• June 16

  • Effects of L-Phenylalanine on Energy Intake and Glycaemia-Impacts on Appetite Perceptions, Gastrointestinal Hormones and Gastric Emptying in Healthy Males.

    • 2020-06-16
    • RCT
    • Nutrients 12(6)
    • • Penelope C E Fitzgerald
      • Benoit Manoliu
      • Benjamin Herbillon
      • Robert E Steinert
      • Michael Horowitz
      • Christine Feinle-Bisset

    • PubMed: 32560181
    • DOI: 10.3390/nu12061788

    9 Insights on

    • Reduced Energy Intake
    • Reduced Glucose Level
    • Reduced Peak Plasma Glucose Level
    • Reduced Gastric Emptying
    • Increased Cholecystokinin Level
    • Increased Peptide YY Level
    • Increased Insulin Level
    • Increased Plasma Glucagon Level
    • Increased Glucagon-Like Peptide 1 Level

    • High evidence
    • Rigorous Journal
• June 18

  • Biosurfactant from vaginal Lactobacillus crispatus BC1 as a promising agent to interfere with Candida adhesion

    • 2020-06-18
    • Clinical Trial
    • Microbial Cell Factories 19(1)
    • • P. R. De Gregorio
      • C. Parolin
      • A. Abruzzo
      • B. Luppi
      • M. Protti
      • L. Mercolini
      • J. A. Silva
      • B. Giordani
      • A. Marangoni
      • M. Nader-Macías
      • B. Vitali

    • PubMed: 32552788
    • DOI: 10.1186/s12934-020-01390-5

    1 Insight on

    • Reduced Leukocyte Influx During C. Albicans Challenge

    • Low evidence
    • Animal Study
• June 19

  • Evaluation of the Inhibitory Effects of Lactobacillus gasseri and Lactobacillus crispatus on the Adhesion of Seven Common Lower Genital Tract Infection-Causing Pathogens to Vaginal Epithelial Cells

    • 2020-06-19
    • Frontiers in Medicine 7
    • • Yuanhui He
      • X. Niu
      • Ben Wang
      • R. Na
      • B. Xiao
      • Huixia Yang

    • PubMed: 32637420
    • DOI: 10.3389/fmed.2020.00284

    9 Insights on

    • Reduced S. aureus Adhesion
    • Reduced Enteropathogenic Escherichia coli (EPEC) Adhesion
    • Reduced Pathogen Adhesion to Vaginal Epithelial Cells
    • Inhibited Adhesion of Staphylococcus Aureus
    • Enhanced Vaginal Epithelial Cell Adhesion
    • Reduced Adhesion of Streptococcus agalactiae
    • Reduced Adhesion of Gardnerella
    • Inhibited Adhesion of Mobiluncus
    • Reduced Adhesion of Enterococcus faecalis

    • Low evidence
• June 25

  • Oral Administration of S-Adenosylmethionine (SAMe) and Lactobacillus Plantarum HEAL9 Improves the Mild-To-Moderate Symptoms of Depression: A Randomized, Double-Blind, Placebo-Controlled Study.

    • 2020-06-25
    • RCT · n = 90
    • The Primary Care Companion For CNS Disorders 22(4)
    • • A. Saccarello
      • Paolo Montarsolo
      • Ivano Massardo
      • R. Picciotto
      • A. Pedemonte
      • R. Castagnaro
      • P. Brasesco
      • Vittorio Guida
      • P. Picco
      • P. Fioravanti
      • R. Montisci
      • I. Schiavetti
      • A. Vanelli

    • PubMed: 32589828
    • DOI: 10.4088/pcc.19m02578

    6 Insights on

    • Improved Cognitive Function
    • Reduced Depression Symptoms
    • Reduced Anxiety
    • Improved Anxiety Symptoms
    • Improved Depressive Symptoms
    • Improved Somatic Symptoms

    • High evidence

  • Biological properties and structural characterization of a novel rhamnolipid like-biosurfactants produced by Lactobacillus casei subsp. casei TM1B.

    • 2020-06-25
    • Biotechnology and applied biochemistry 68(3)
    • • Hippolyte T Mouafo
      • Augustin Mbawala
      • Devappa Somashekar
      • Hervé M Tchougang
      • Nanishankar V Harohally
      • Robert Ndjouenkeu

    • PubMed: 32497351
    • DOI: 10.1002/bab.1966

    2 Insights on

    • Increased Antioxidant Activity
    • Reduced Metal Ion Burden

    • Low evidence
• June 29

  • Lactobacillus plantarum DR7 Modulated Bowel Movement and Gut Microbiota Associated with Dopamine and Serotonin Pathways in Stressed Adults

    • 2020-06-29
    • RCT
    • International Journal of Molecular Sciences 21(13)
    • • Guoxia Liu
      • H. Chong
      • F. Chung
      • Yin Li
      • M. Liong

    • PubMed: 32610495
    • DOI: 10.3390/ijms21134608

    2 Insights on

    • Improved Gut Microbiota Diversity
    • Improved Bowel Movements

    • High evidence

  • Effect of Multi-strain Probiotic Formulation on Students Facing Examination Stress: a Double-Blind, Placebo-Controlled Study

    • 2020-06-29
    • RCT · n = 80
    • Probiotics and Antimicrobial Proteins 13(1)
    • • R. Venkataraman
      • R. Madempudi
      • J. Neelamraju
      • J. Ahire
      • H. Vinay
      • Anila Lal
      • Glory Thomas
      • S. Stephen

    • PubMed: 32601955
    • DOI: 10.1007/s12602-020-09681-4

    2 Insights on

    • Reduced Subjective Stress Levels
    • Reduced Stress Levels

    • High evidence
• June 30

  • Effect of Lactobacillus sakei, a Probiotic Derived from Kimchi, on Body Fat in Koreans with Obesity: A Randomized Controlled Study

    • 2020-06-30
    • RCT · n = 114
    • Endocrinology and Metabolism 35(2)
    • • Soo Lim
      • J. Moon
      • C. Shin
      • Dahye Jeong
      • Bongjoon Kim

    • PubMed: 32615727
    • DOI: 10.3803/EnM.2020.35.2.425

    3 Insights on

    • Reduced Waist Circumference
    • Reduced Body Fat Mass
    • Absence of Serious Side Effects

    • High evidence
    • Rigorous Journal

  • An Oral Formulation of the Probiotic, Bacillus subtilis HU58, Was Safe and Well Tolerated in a Pilot Study of Patients with Hepatic Encephalopathy

    • 2020-06-30
    • RCT · n = 40
    • Evidence-Based Complementary and Alternative Medicine 2020
    • • S. Yossef
      • F. Clark
      • Sarah S Bubeck
      • J. Abernethy
      • Thomas Bayne
      • K. Krishnan
      • Aicacia Young

    • PubMed: 32714397
    • DOI: 10.1155/2020/1463108

    2 Insights on

    • Reduced Blood Ammonia Levels
    • Reduced Blood Ammonia Level

    • High evidence
    • Rigorous Journal
• Undated – 5 supplement studies

  • Lactobacillus plantarum L-137 and/or β-glucan impacted the histopathological, antioxidant, immune-related genes and resistance of Nile tilapia (Oreochromis niloticus) against Aeromonas hydrophila.

    • 2020-06
    • RCT
    • Research in Veterinary Science 130
    • • M. Dawood
      • E. Moustafa
      • Z. Elbialy
      • F. Farrag
      • Emad. E. Lolo
      • Hanaa A Abdel-Daim
      • Mohamed M. Abdel-Daim
      • Hien Van Doan

    • PubMed: 32203766
    • DOI: 10.1016/j.rvsc.2020.03.019

    14 Insights on

    • Increased PMN Cell Phagocytic Capacity
    • Increased Body Weight
    • Increased Serum Albumin Levels
    • Improved Immune Response
    • Improved Growth Performance
    • Improved Growth Rate
    • Reduced Serum Malondialdehyde Levels
    • Improved Total Antioxidant Status
    • Increased Hemoglobin Levels
    • Improved Intestinal Villi Epithelium Integrity
    • Reduced Hepatocyte Necrosis
    • Increased Red Blood Cell Count
    • Improved Hematological Parameters
    • Enhanced Resistance to Bacterial Infections

    • Low evidence
    • Animal Study

  • Preventive effect of Lactobacillus reuteri on melanoma.

    • 2020-06
    • Clinical Trial
    • Biomedicine & Pharmacotherapy 126
    • • Meng Luo
      • Miaomiao Hu
      • Xu Feng
      • W. Xiaoli
      • Degang Dong
      • Wanchun Wang

    • PubMed: 32126498
    • DOI: 10.1016/j.biopha.2020.109929

    3 Insights on

    • Reduced Incidence of Melanoma
    • Increased Survival in Tumor-Bearing Mice
    • Maintained Normal ALT Levels

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Lactobacillus rhamnosus FLRH93 protects against intestinal damage in mice induced by 5-fluorouracil.

    • 2020-06
    • Clinical Trial
    • Journal of Dairy Science 103(6)
    • • Miaomiao Hu
      • Xiaoli Wu
      • Meng Luo
      • Hua Wei
      • Di Xu
      • Feng Xu

    • PubMed: 32229117
    • DOI: 10.3168/jds.2019-17836

    4 Insights on

    • Improved Survival Rate
    • Reduced Inflammatory Response
    • Improved Intestinal Function
    • Improved Villus:Crypt Ratio

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Unexpected effect of probiotics by Lactococcus lactis subsp. lactis against colitis induced by dextran sulfate sodium in mice.

    • 2020-06
    • Clinical Trial
    • Journal of Infection and Chemotherapy 26(6)
    • • Shinichirou Komaki
      • A. Haque
      • H. Miyazaki
      • Tetsuya Matsumoto
      • Shigeki Nakamura

    • PubMed: 32122783
    • DOI: 10.1016/j.jiac.2020.01.006

    3 Insights on

    • Increased Colon Inflammation
    • Reduced Survival Rate
    • Increased Inflammatory Cytokines

    • Low evidence
    • Animal Study

  • Effects of skim milk fermented with Lactobacillus plantarum WW on the constitutions of rats fed a high-fat diet.

    • 2020-06
    • RCT
    • Journal of Dairy Science 103(6)
    • • Yang Li
      • Junrui Wu
      • Chengxu Cao
      • Xinyuan Zhu
      • Xueting Sun
      • R. Wu

    • PubMed: 32278555
    • DOI: 10.3168/jds.2019-17560

    21 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Total Cholesterol Levels
    • Increased Lactic Acid Bacteria Levels
    • Improved Intestinal Microbiota
    • Reduced Blood Lipid Levels
    • Improved Lipid Metabolism
    • Reduced Symptoms Associated with High-Fat Diet
    • Increased Beneficial Gut Microbiota
    • Reduced Pathological Symptoms
    • Regulated Intestinal Microorganisms
    • Altered Lipid Metabolism
    • Reduced Hyperlipidemia Symptoms
    • Improved Intestinal Microbial Composition
    • Enhanced Beneficial Gut Microbiota
    • Improved Fat Metabolism Regulation
    • Increased Autochthonous Lactic Acid Bacteria Levels
    • Regulated Gut Microbiota
    • Improved Beneficial Intestinal Bacteria
    • Increased Bacteroides Levels in the Intestine
    • Reduced Symptoms of High-Fat Diet Pathologies
    • Increased Beneficial Intestinal Microorganisms

    • Low evidence
    • Rigorous Journal
    • Animal Study