April 2022 Supplement Research Papers

• April 1

  • Efficacy of Probiotics for Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis.

    • 2022-04-01
    • Systematic Review
    • Frontiers in cellular and infection microbiology 12
    • • Tao Zhang
      • Cunzheng Zhang
      • Jindong Zhang
      • Feng Sun
      • Liping Duan

    • PubMed: 35433498
    • DOI: 10.3389/fcimb.2022.859967

    6 Insights on

    • Reduced Straining
    • Improved Quality of Life
    • Reduced Flatulence
    • Reduced Abdominal Pain
    • Improved Irritable Bowel Syndrome Symptom Relief Rate
    • Improved Global Symptom Score

    • High evidence

  • Prebiotic Galacto-Oligosaccharides and Fructo-Oligosaccharides, but Not Acacia Gum, Increase Iron Absorption from a Single High-Dose Ferrous Fumarate Supplement in Iron-Depleted Women.

    • 2022-04-01
    • RCT · n = 30
    • The Journal of nutrition 152(4)
    • • Ambra Giorgetti
      • Frederike M D Husmann
      • Christophe Zeder
      • Isabelle Herter-Aeberli
      • Michael B Zimmermann

    • PubMed: 35015879
    • DOI: 10.1093/jn/nxac003

    1 Insight on

    • Improved Iron Absorption

    • High evidence
• April 4

  • Lactobacillus paracasei 24 Attenuates Lipid Accumulation in High-Fat Diet-Induced Obese Mice by Regulating the Gut Microbiota.

    • 2022-04-04
    • Clinical Trial
    • Journal of Agricultural and Food Chemistry 70(15)
    • • Zhijing Liu
      • Xuan Zhou
      • Wan Wang
      • Liya Gu
      • Chuanbing Hu
      • Hong Sun
      • Cong Xu
      • J. Hou
      • Zhan-mei Jiang

    • PubMed: 35377154
    • DOI: 10.1021/acs.jafc.1c07884

    7 Insights on

    • Improved Gut Microbiota Diversity
    • Reduced Body Weight
    • Reduced Inflammatory Response
    • Reduced Blood Lipid Levels
    • Reduced Liver Fat
    • Reduced Liver Oxidative Stress Injury
    • Improved Fat Metabolism Regulation

    • Low evidence
    • Animal Study
• April 6

  • Lactobacillus spp. for Gastrointestinal Health: Current and Future Perspectives.

    • 2022-04-06
    • Review
    • Frontiers in immunology 13
    • • Elaine Dempsey
      • Sinéad C Corr

    • PubMed: 35464397
    • DOI: 10.3389/fimmu.2022.840245

    1 Insight on

    • Improved Gastrointestinal Health

    • Moderate evidence
    • Highly Cited
• April 7

  • Effects of Rhodiola Rosea Supplementation on Exercise and Sport: A Systematic Review.

    • 2022-04-07
    • Systematic Review · n = 10
    • Frontiers in nutrition 9
    • • Yao Lu
      • Bin Deng
      • Luhua Xu
      • Hanjiao Liu
      • Yinzhi Song
      • Fengxia Lin

    • PubMed: 35464040
    • DOI: 10.3389/fnut.2022.856287

    7 Insights on

    • Reduced Oxidative Stress
    • Increased Antioxidant Capacity
    • Reduced Muscle Damage
    • Reduced Pain
    • Improved Skeletal Muscle Damage
    • Reduced Rating of Perceived Exertion
    • Improved Athletic Explosive Power

    • High evidence

  • The Anti-Cancer Potential of Heat-Killed Lactobacillus brevis KU15176 upon AGS Cell Lines through Intrinsic Apoptosis Pathway

    • 2022-04-07
    • International Journal of Molecular Sciences 23(8)
    • • Chang-Hoon Hwang
      • N. Lee
      • H. Paik

    • PubMed: 35456891
    • DOI: 10.3390/ijms23084073

    1 Insight on

    • Reduced Inflammation Levels

    • Low evidence
• April 8

  • Healthy Vaginal Microbiota and Influence of Probiotics Across the Female Life Span.

    • 2022-04-08
    • Review
    • Frontiers in microbiology 13
    • • Liisa Lehtoranta
      • Reeta Ala-Jaakkola
      • Arja Laitila
      • Johanna Maukonen

    • PubMed: 35464937
    • DOI: 10.3389/fmicb.2022.819958

    1 Insight on

    • Improved Vaginal Microbiota Balance

    • Low evidence

  • Anti-Melanogenic and Antioxidant Effects of Cell-Free Supernatant from Lactobacillus gasseri BNR17

    • 2022-04-08
    • Microorganisms 10(4)
    • • Sol Lee
      • Han-Oh Park
      • W. Yoo

    • PubMed: 35456838
    • DOI: 10.3390/microorganisms10040788

    4 Insights on

    • Reduced Hepatic Oxidative Stress
    • Reduced Oxidative Stress
    • Reduced Melanin Production
    • Reduced Melanogenesis

    • Low evidence
    • Rigorous Journal
• April 13

  • Bifidobacterium infantis treatment promotes weight gain in Bangladeshi infants with severe acute malnutrition

    • 2022-04-13
    • RCT
    • Science Translational Medicine 14(640)
    • • Michael J. Barratt
      • Sharika Nuzhat
      • Kazi Ahsan
      • S. Frese
      • Aleksandr A. Arzamasov
      • S. Sarker
      • M. M. Islam
      • P. Palit
      • Md. Ridwan Islam
      • M. Hibberd
      • Swetha Nakshatri
      • Carrie A. Cowardin
      • J. Guruge
      • A. Byrne
      • Siddarth Venkatesh
      • Vinaik Sundaresan
      • B. Henrick
      • R. Duar
      • Ryan D. Mitchell
      • G. Casaburi
      • Johann Prambs
      • Robin L. Flannery
      • M. Mahfuz
      • D. Rodionov
      • A. Osterman
      • David Kyle
      • T. Ahmed
      • J. Gordon

    • PubMed: 35417188
    • DOI: 10.1126/scitranslmed.abk1107

    3 Insights on

    • Increased Body Weight
    • Reduced Intestinal Inflammation
    • Promoted Weight Gain

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Therapeutic Efficacy of Flavonoids in Allergies: A Systematic Review of Randomized Controlled Trials.

    • 2022-04-13
    • Systematic Review · n = 990
    • Journal of immunology research 2022
    • • Poliana Guiomar de Almeida Brasiel
      • Fernanda Verdini Guimarães
      • Patrícia Machado Rodrigues
      • Dumith Chequer Bou-Habib
      • Vinicius de Frias Carvalho

    • PubMed: 35465348
    • DOI: 10.1155/2022/8191253

    2 Insights on

    • Improved Lung Function
    • Reduced Allergic Symptom Score

    • High evidence
• April 15

  • The Impacts of Lactiplantibacillus plantarum on the Functional Properties of Fermented Foods: A Review of Current Knowledge

    • 2022-04-15
    • Review
    • Microorganisms 10(4)
    • • Birsen Yılmaz
      • S. Bangar
      • N. Echegaray
      • S. Suri
      • I. Tomasevic
      • José Manuel Lorenzo
      • E. Melekoglu
      • J. Rocha
      • F. Ozogul

    • PubMed: 35456875
    • DOI: 10.3390/microorganisms10040826

    3 Insights on

    • Enhanced Antioxidant Activity
    • Improved Flavor Perception
    • Reduced Undesirable Compounds

    • Moderate evidence
    • Rigorous Journal

  • Lacticaseibacillus rhamnosus FM9 and Limosilactobacillus fermentum Y57 Are as Effective as Statins at Improving Blood Lipid Profile in High Cholesterol, High-Fat Diet Model in Male Wistar Rats

    • 2022-04-15
    • Clinical Trial
    • Nutrients 14(8)
    • • Hamza Zafar
      • Namrah Zafar
      • Abdulrahman Alshammari
      • Saeed S Alghamdi
      • Hafsa Raja
      • Amjad Ali
      • Abubakar Siddique
      • Syeda Duaa Tahir
      • S. Akbar
      • Maryum Arif
      • M. Alharbi
      • Abdur Rahman

    • PubMed: 35458216
    • DOI: 10.3390/nu14081654

    4 Insights on

    • Reduced LDL Cholesterol
    • Reduced Serum Total Cholesterol Levels
    • Improved Cholesterol Levels
    • Improved Weight Control

    • Low evidence
    • Animal Study
• April 17

  • Lactobacillus casei Improve Anti-Tuberculosis Drugs-Induced Intestinal Adverse Reactions in Rat by Modulating Gut Microbiota and Short-Chain Fatty Acids

    • 2022-04-17
    • Clinical Trial
    • Nutrients 14(8)
    • • Yue Li
      • Liangjie Zhao
      • Meiling Hou
      • Tianlin Gao
      • J. Sun
      • Hao Luo
      • Fengdan Wang
      • Feng Zhong
      • Aiguo Ma
      • Jing Cai

    • PubMed: 35458230
    • DOI: 10.3390/nu14081668

    3 Insights on

    • Increased Proportion of Intestinal Goblet Cells
    • Restored Mucin-2 Levels
    • Increased Hexanoic Acid Levels

    • Low evidence
    • Animal Study
• April 18

  • The Effect of Enterococcus faecium AL41 on the Acute Phase Proteins and Selected Mucosal Immune Molecules in Broiler Chickens

    • 2022-04-18
    • RCT · n = 80
    • Life 12(4)
    • • V. Karaffová
      • C. Tóthová
      • R. Szabóová
      • V. Révajová
      • A. Lauková
      • Z. Ševčíková
      • R. Herich
      • R. Žitňan
      • M. Levkut
      • M. Levkut
      • Z. Faixová
      • O. Nagy

    • PubMed: 35455089
    • DOI: 10.3390/life12040598

    2 Insights on

    • Enhanced Mucosal Immune Function
    • Improved Immunity Status

    • Low evidence
    • Animal Study
• April 19

  • The Gut Microbiome in Depression and Potential Benefit of Prebiotics, Probiotics and Synbiotics: A Systematic Review of Clinical Trials and Observational Studies.

    • 2022-04-19
    • Systematic Review · n = 2,817
    • International journal of molecular sciences 23(9)
    • • Sauliha R Alli
      • Ilona Gorbovskaya
      • Jonathan C W Liu
      • Nathan J Kolla
      • Lisa Brown
      • Daniel J Müller

    • PubMed: 35562885
    • DOI: 10.3390/ijms23094494

    1 Insight on

    • Reduced Depression Symptoms

    • High evidence
    • Highly Cited
    • Rigorous Journal
• April 21

  • Three important short-chain fatty acids (SCFAs) attenuate the inflammatory response induced by 5-FU and maintain the integrity of intestinal mucosal tight junction.

    • 2022-04-21
    • BMC immunology 23(1)
    • • Xi Yue
      • Sun Wen
      • Ding Long-Kun
      • Yan Man
      • Sun Chang
      • Zhang Min
      • Li Shuang-Yu
      • Qian Xin
      • Ma Jie
      • Wu Liang

    • PubMed: 35448938
    • DOI: 10.1186/s12865-022-00495-3

    2 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Intestinal Inflammation

    • Low evidence
• April 25

  • Influence of 2'-Fucosyllactose and Bifidobacterium longum Subspecies infantis Supplementation on Cognitive and Structural Brain Development in Young Pigs.

    • 2022-04-25
    • RCT
    • Frontiers in neuroscience 16
    • • Loretta T Sutkus
      • Sangyun Joung
      • Johanna Hirvonen
      • Henrik Max Jensen
      • Arthur C Ouwehand
      • Ratna Mukherjea
      • Sharon M Donovan
      • Ryan N Dilger

    • PubMed: 35546890
    • DOI: 10.3389/fnins.2022.860368

    1 Insight on

    • Improved Delayed Memory

    • High evidence
• April 26

  • Role of Lipoteichoic Acid from the Genus Apilactobacillus in Inducing a Strong IgA Response.

    • 2022-04-26
    • Applied and environmental microbiology 88(8)
    • • Chiaki Matsuzaki
      • Tsukasa Shiraishi
      • Tai-Ying Chiou
      • Yukari Nakashima
      • Yasuki Higashimura
      • Shin-Ichi Yokota
      • Kenji Yamamoto
      • Tomoya Takahashi

    • PubMed: 35380450
    • DOI: 10.1128/aem.00190-22

    2 Insights on

    • Increased Immune Response
    • Increased IgA-Inducing Activity

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Lactobacillus delbrueckii CIDCA 133 Ameliorates Chemotherapy-Induced Mucositis by Modulating Epithelial Barrier and TLR2/4/Myd88/NF-κB Signaling Pathway

    • 2022-04-26
    • Clinical Trial
    • Frontiers in Microbiology 13
    • • F. A. L. Barroso
      • L. D. de Jesus
      • T. F. da Silva
      • V. L. Batista
      • J. Laguna
      • N. D. Coelho-Rocha
      • K. D. Vital
      • S. O. Fernandes
      • V. Cardoso
      • Ê. Ferreira
      • F. S. Martins
      • M. M. Drumond
      • Pamela Mancha-Agresti
      • Alexander Birbrair
      • D. Barh
      • V. Azevedo

    • PubMed: 35558121
    • DOI: 10.3389/fmicb.2022.858036

    7 Insights on

    • Reduced Intestinal Permeability
    • Reduced Inflammatory Response
    • Improved Intestinal Mucosa Architecture
    • Reduced Immune Cell Infiltration
    • Increased Ileal Goblet Cell Count
    • Improved Small Intestine Length
    • Reduced Villus Atrophy

    • Low evidence
    • Animal Study
• April 27

  • Evaluation of Modulatory Activities of Lactobacillus crispatus Strains in the Context of the Vaginal Microbiota

    • 2022-04-27
    • Microbiology Spectrum 10(2)
    • • Chiara Argentini
      • Federico Fontana
      • Giulia Alessandri
      • G. Lugli
      • Leonardo Mancabelli
      • M. C. Ossiprandi
      • D. van Sinderen
      • M. Ventura
      • C. Milani
      • F. Turroni

    • PubMed: 35266820
    • DOI: 10.1128/spectrum.02733-21

    3 Insights on

    • Enhanced Natural Killer Cell Tumoricidal Activity
    • Improved Antibacterial Activity
    • Improved Niche Colonization

    • Low evidence

  • Therapeutic Effects of Bifidobacterium breve YH68 in Combination with Vancomycin and Metronidazole in a Primary Clostridioides difficile-Infected Mouse Model

    • 2022-04-27
    • Clinical Trial
    • Microbiology Spectrum 10(2)
    • • Jingpeng Yang
      • Lingtong Meng
      • Hong Yang

    • PubMed: 35311540
    • DOI: 10.1128/spectrum.00672-22

    7 Insights on

    • Improved Survival Rate
    • Reduced Uric Acid Levels
    • Reduced Pro-inflammatory Cytokine Levels
    • Increased Abundance of Beneficial Gut Genera
    • Improved Fecal Microbiota Diversity
    • Increased Levels of Beneficial Metabolites
    • Reduced Antibiotic Damage to Microbiota

    • Low evidence
    • Animal Study

  • Correction: Improvement of loperamide-induced slow transit constipation by Bifidobacterium bifidum G9-1 is mediated by the correction of butyrate production and neurotransmitter profile due to improvement in dysbiosis.

    • 2022-04-27
    • PloS one 17(4)
    • • Yutaka Makizaki
      • Taiki Uemoto
      • Haruka Yokota
      • Miyuki Yamamoto
      • Yoshiki Tanaka
      • Hiroshi Ohno

    • PubMed: 35476793
    • DOI: 10.1371/journal.pone.0267927

    5 Insights on

    • Improved Gut Microbiome
    • Improved Chronic Constipation
    • Increased Butyrate Production
    • Improved Transit Time
    • Improved Neurotransmitter Profile

    • Low evidence
• April 28

  • Biological Functions of Exopolysaccharides from Lactic Acid Bacteria and Their Potential Benefits for Humans and Farmed Animals.

    • 2022-04-28
    • Review
    • Foods (Basel, Switzerland) 11(9)
    • • María Laura Werning
      • Annel M Hernández-Alcántara
      • María Julia Ruiz
      • Lorena Paola Soto
      • María Teresa Dueñas
      • Paloma López
      • Laureano Sebastián Frizzo

    • PubMed: 35564008
    • DOI: 10.3390/foods11091284

    3 Insights on

    • Improved Gut Health
    • Improved Human Health
    • Improved Animal Growth and Health

    • Low evidence

  • In vitro Study of Bifidobacterium lactis BL-99 With Fructooligosaccharide Synbiotics Effected on the Intestinal Microbiota.

    • 2022-04-28
    • Frontiers in nutrition 9
    • • Qi Zhang
      • Wen Zhao
      • Yuyang Zhao
      • Sufang Duan
      • Wei-Hsien Liu
      • Chao Zhang
      • Siyuan Sun
      • Tingting Wang
      • Xin Wang
      • Wei-Lian Hung
      • Ran Wang

    • PubMed: 35571919
    • DOI: 10.3389/fnut.2022.890316

    3 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Flatulence
    • Increased Production of Acetate

    • Low evidence
• April 29

  • Probiotics in Citrus Fruits Products: Health Benefits and Future Trends for the Production of Functional Foods-A Bibliometric Review.

    • 2022-04-29
    • Review
    • Foods (Basel, Switzerland) 11(9)
    • • Shênia Santos Monteiro
      • Verônica Macário de Oliveira
      • Matheus Augusto de Bittencourt Pasquali

    • PubMed: 35564022
    • DOI: 10.3390/foods11091299

    3 Insights on

    • Improved Immune Function
    • Improved Skin Hydration
    • Improved Skin Health

    • Low evidence

  • Probiotic Mixture Containing Lactobacillus helveticus, Bifidobacterium longum and Lactiplantibacillus plantarum Affects Brain Responses Toward an Emotional Task in Healthy Subjects: A Randomized Clinical Trial

    • 2022-04-29
    • RCT · n = 22
    • Frontiers in Nutrition 9
    • • Julia Rode
      • Hanna M. T. Edebol Carlman
      • J. König
      • Dirk Repsilber
      • A. N. Hutchinson
      • P. Thunberg
      • P. Andersson
      • J. Persson
      • A. Kiselev
      • Lori Lathrop Stern
      • B. Salomon
      • Ahmed Abdulilah Mohammed
      • J. Labus
      • R. Brummer

    • PubMed: 35571902
    • DOI: 10.3389/fnut.2022.827182

    1 Insight on

    • Enhanced Orbitofrontal Cortex Activation

    • High evidence

  • The Probiotic Strain Bifidobacterium animalis ssp. lactis HY8002 Potentially Improves the Mucosal Integrity of an Altered Intestinal Microbial Environment

    • 2022-04-29
    • Frontiers in Microbiology 13
    • • Joo-Yun Kim
      • S. Bang
      • Ju-Yeon Kim
      • Eunhye Choi
      • K. Heo
      • Jae-Jung Shim
      • Jung-Lyoul Lee

    • PubMed: 35572671
    • DOI: 10.3389/fmicb.2022.817591

    4 Insights on

    • Improved Intestinal Barrier Function
    • Enhanced Intestinal Immunity
    • Increased Immunoglobulin A Levels
    • Restored Microbiome Composition

    • Low evidence
• April 30

  • Identification, Biochemical Characterization, and Safety Attributes of Locally Isolated Lactobacillus fermentum from Bubalus bubalis (buffalo) Milk as a Probiotic

    • 2022-04-30
    • Clinical Trial
    • Microorganisms 10(5)
    • • S. Abid
      • A. Farid
      • Rameesha Abid
      • M. Rehman
      • Walaa F. Alsanie
      • M. Alhomrani
      • A. Alamri
      • S. M. Asdaq
      • D. Hefft
      • S. Saqib
      • M. Muzammal
      • S. Morshedy
      • Mashael W Alruways
      • S. Ghazanfar

    • PubMed: 35630398
    • DOI: 10.3390/microorganisms10050954

    3 Insights on

    • Increased Safety
    • Enhanced Gut Health
    • No Histological Dysfunction

    • Low evidence
    • Rigorous Journal
    • Animal Study
• Undated – 3 supplement studies

  • Intake of Bifidobacterium lactis Probio-M8 fermented milk protects against alcoholic liver disease.

    • 2022-04
    • Journal of dairy science 105(4)
    • • Qiuwen He
      • Chengcong Yang
      • Xiaohong Kang
      • Yongfu Chen
      • Tao Zhang
      • Heping Zhang
      • Lai-Yu Kwok

    • PubMed: 35086715
    • DOI: 10.3168/jds.2021-21265

    1 Insight on

    • Reduced Liver Disease Symptoms

    • Low evidence
    • Animal Study

  • Optimising the management of childhood acute diarrhoeal disease using a rapid test-and- treat strategy and/or Lactobacillus reuteri DSM 17938: a multicentre, randomised, controlled, factorial trial in Botswana

    • 2022-04
    • RCT · n = 272
    • BMJ Global Health 7(4)
    • • J. Pernica
      • T. Arscott-Mills
      • A. Steenhoff
      • M. Mokomane
      • Banno Moorad
      • Mbabi Bapabi
      • K. Lechiile
      • Oarabile Mangwegape
      • Boswa Batisani
      • Norah Mawoko
      • Charles Muthoga
      • T. Vanniyasingam
      • Joycelyne E Ewusie
      • Amy Lowe
      • Janice M Bonsu
      • Alemayehu Mekonnen Gezmu
      • M. Smieja
      • L. Mazhani
      • K. Størdal
      • L. Thabane
      • M. Kelly
      • D. Goldfarb

    • PubMed: 35418412
    • DOI: 10.1136/bmjgh-2021-007826

    3 Insights on

    • Improved Growth
    • Improved Age-Standardized Height
    • Adjusted Height-for-Age Z Score

    • High evidence
    • Rigorous Journal

  • Acid stress responses of Lactobacillus amylovorus and Candida kefyr isolated from fermented sorghum gruel and their application in food fermentation.

    • 2022-04
    • Canadian Journal of Microbiology 68(4)
    • • Oluwaseun Adeola Adewara
      • S. Ogunbanwo

    • PubMed: 35038286
    • DOI: 10.1139/cjm-2021-0118

    2 Insights on

    • Reduced Antinutrient Levels
    • Improved Nutritional Value

    • Low evidence