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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Gamma-aminobutyric acid for delaying type 1 diabetes mellitus: an update.
- 2024-06-30
- Review
- Annals of pediatric endocrinology & metabolism 29(3)
- - Jane Carissa Sutedja
  - Bryan Gervais de Liyis
  - Made Ratna Saraswati
- PubMed: 38956751
- DOI: 10.6065/apem.2346184.092
1 Insight on
- Delayed Onset of Type 1 Diabetes Mellitus
- Low evidence
Effect of Green Tea Supplementation on Inflammatory Markers among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis.
- 2024-06-30
- Review
- Preventive nutrition and food science 29(2)
- - Fernanda Souza de Oliveira Assis
  - Gabriel Lima Vasconcellos
  - Diego José Pereira Lopes
  - Leandro Roberto de Macedo
  - Maísa Silva
- PubMed: 38974590
- DOI: 10.3746/pnf.2024.29.2.106
3 Insights on
- Low evidence
Efficacy of a yeast postbiotic on cold/flu symptoms in healthy children: A randomized-controlled trial.
- 2024-06-28
- RCT
- Pediatric research 96(7)
- - Ruma G Singh
  - Vicenta Garcia-Campayo
  - Justin B Green
  - Neil Paton
  - Julissa D Saunders
  - Huda Al-Wahsh
  - David C Crowley
  - Erin D Lewis
  - Malkanthi Evans
  - Marc Moulin
- PubMed: 38942887
- DOI: 10.1038/s41390-024-03331-z
2 Insights on
- Reduced Cold/Flu Severity
- Reduced Cold/Flu Medication Use
- High evidence
Exploring the gut microbiome: probiotics, prebiotics, synbiotics, and postbiotics as key players in human health and disease improvement.
- 2024-06-27
- Review
- Food science and biotechnology 33(9)
- - You-Tae Kim
  - David A Mills
- PubMed: 39130661
- DOI: 10.1007/s10068-024-01620-1
2 Insights on
- Improved Gut Microbiota Composition
- Improved Clinical Outcomes
- Low evidence
Breed-Driven Microbiome Heterogeneity Regulates Intestinal Stem Cell Proliferation via Lactobacillus-Lactate-GPR81 Signaling.
- 2024-06-27
- Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11(33)
- - Haiqin Wu
  - Chunlong Mu
  - Xuan Li
  - Wenlu Fan
  - Le Shen
  - Weiyun Zhu
- PubMed: 38937989
- DOI: 10.1002/advs.202400058
3 Insights on
- Low evidence
- Animal Study
Cognitive and Emotional Effect of a Multi-species Probiotic Containing Lactobacillus rhamnosus and Bifidobacterium lactis in Healthy Older Adults: A Double-Blind Randomized Placebo-Controlled Crossover Trial.
- 2024-06-27
- RCT
- Probiotics and antimicrobial proteins 17(5)
- - Cristofer Ruiz-Gonzalez
  - Diana Cardona
  - Lola Rueda-Ruzafa
  - Miguel Rodriguez-Arrastia
  - Carmen Ropero-Padilla
  - Pablo Roman
- PubMed: 38935259
- DOI: 10.1007/s12602-024-10315-2
3 Insights on
- High evidence
Natural Health Products for Anti-Cancer Treatment: Evidence and Controversy.
- 2024-06-26
- Review
- Journal of personalized medicine 14(7)
- - Valeria Conti
  - Giovanna Polcaro
  - Emanuela De Bellis
  - Danilo Donnarumma
  - Federica De Rosa
  - Berenice Stefanelli
  - Graziamaria Corbi
  - Francesco Sabbatino
  - Amelia Filippelli
- PubMed: 39063939
- DOI: 10.3390/jpm14070685
2 Insights on
- Reduced Adverse Event from Radiotherapy or Chemotherapy
- Improved Prostate Cancer Outcome
- Low evidence
Efficacy of Pea Protein Supplementation in Combination with a Resistance Training Program on Muscle Performance in a Sedentary Adult Population: A Randomized, Comparator-Controlled, Parallel Clinical Trial.
- 2024-06-26
- RCT
- Nutrients 16(13)
- - Ruma G Singh
  - Laetitia Guérin-Deremaux
  - Catherine Lefranc-Millot
  - Caroline Perreau
  - David C Crowley
  - Erin D Lewis
  - Malkanthi Evans
  - Marc Moulin
- PubMed: 38999765
- DOI: 10.3390/nu16132017
1 Insight on
- Improved Muscle Strength
- High evidence
- Rigorous Journal
Vitamin E for the Prevention of Contrast-Induced Nephropathy: A Systematic Review and Meta-Analysis.
- 2024-06-26
- Review · n = 5
- Cureus 16(6)
- - Ahmed Ali Awaji
  - Basel H Bakhamees
  - Nouf K Alalshaikh
  - Nawaf M Albelwi
  - Mead M Al-Zahrani
  - Khalaf F Alshammari
  - Shaden D Almutairi
  - Ilaf M Siraj
  - Taif N Aljaber
  - Raghad S Alnajdi
  - Shatha S Al-Majnooni
  - Abdulaziz S Alserhani
- PubMed: 39070434
- DOI: 10.7759/cureus.63256
1 Insight on
- Reduced Contrast-Induced Nephropathy
- Low evidence
An exploratory study of a multi-species probiotic formulation and markers of health in a real-world oncological cohort in the time of covid.
- 2024-06-26
- Clinical Trial
- Inflammopharmacology 32(4)
- - Michael Thomsen
  - Ravichandra Vemuri
  - Flavia Huygens
  - Stephen Clarke
  - Luis Vitetta
- PubMed: 38926298
- DOI: 10.1007/s10787-024-01503-1
8 Insights on
- Moderate evidence
Bifidobacterium lactis and Lactobacillus plantarum Enhance Immune Function and Antioxidant Capacity in Cats through Modulation of the Gut Microbiota.
- 2024-06-25
- Antioxidants (Basel, Switzerland) 13(7)
- - Weiwei Wang
  - Hao Dong
  - Xiaohan Chang
  - Qianqian Chen
  - Longjiao Wang
  - Shuxing Chen
  - Lishui Chen
  - Ran Wang
  - Shaoyang Ge
  - Pengjie Wang
  - Yixuan Li
  - Siyuan Liu
  - Wei Xiong
- PubMed: 39061833
- DOI: 10.3390/antiox13070764
5 Insights on
- Low evidence
Effects of cinnamon supplementation on metabolic biomarkers in individuals with type 2 diabetes: a systematic review and meta-analysis.
- 2024-06-25
- Meta-Analysis · n = 3,054
- Nutrition reviews 83(2)
- - Suzana Laís de Moura
  - Bruna Gabrielle Rocha Gomes
  - Mariana Julião Guilarducci
  - Olívia Gonçalves Leão Coelho
  - Nathalia Sernizon Guimarães
  - Júnia Maria Geraldo Gomes
- PubMed: 38917435
- DOI: 10.1093/nutrit/nuae058
8 Insights on
- High evidence
Characterization of a Ligilactobacillus salivarius Strain Isolated from a Cheese Seal Which Was Last Used in 1936.
- 2024-06-25
- Case Report
- Foods (Basel, Switzerland) 13(13)
- - Claudio Alba
  - Rebeca Arroyo
  - Leónides Fernández
  - Arjan Narbad
  - Juan M Rodríguez
- PubMed: 38998510
- DOI: 10.3390/foods13132005
3 Insights on
- Low evidence
Probiotics for oral health: a critical evaluation of bacterial strains.
- 2024-06-24
- Review
- Frontiers in microbiology 15
- - Rachelle E Beattie
- PubMed: 38979537
- DOI: 10.3389/fmicb.2024.1430810
5 Insights on
- Low evidence
Echinacea Supplementation Does Not Impact Aerobic Capacity and Erythropoiesis in Athletes: A Meta-Analysis.
- 2024-06-22
- Meta-Analysis · n = 107
- Nutrients 16(13)
- - Stephanie Deccy
  - Callie Bartkowiak
  - Nathan Rodricks
  - Kristopher Paultre
- PubMed: 38999738
- DOI: 10.3390/nu16131991
3 Insights on
- High evidence
- Rigorous Journal
AG1®, a Novel Synbiotic, Maintains Gut Barrier Function following Inflammatory Challenge in a Caco-2/THP1-Blue™ Co-Culture Model.
- 2024-06-21
- Microorganisms 12(7)
- - Philip A Sapp
  - Jeremy R Townsend
  - Trevor O Kirby
  - Marlies Govaert
  - Cindy Duysburgh
  - Lynn Verstrepen
  - Massimo Marzorati
  - Tess M Marshall
  - Ralph Esposito
- PubMed: 39065031
- DOI: 10.3390/microorganisms12071263
1 Insight on
- Improved Gut Barrier Function
- Low evidence
Evaluation of 12-Week Standardized Beetroot Extract Supplementation in Older Participants: A Preliminary Study of Human Health Safety.
- 2024-06-19
- RCT
- Nutrients 16(12)
- - Vivian Dos Santos Pinheiro
  - Olavo João Frederico Ramos Junior
  - Caroline Flach Ortmann
  - Anurag Pande
  - Carlos Adam Conte-Junior
  - Thiago Silveira Alvares
- PubMed: 38931296
- DOI: 10.3390/nu16121942
2 Insights on
- Improved Insulin Levels
- Increased Nitrate Level
- High evidence
- Rigorous Journal
Probiotic-Reduced Inflammaging in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
- 2024-06-19
- RCT · n = 66
- Probiotics and antimicrobial proteins 17(5)
- - Irini Lazou-Ahrén
  - Malin Björklund
  - Göran Molin
  - Jie Xu
  - Gunilla Önning
  - Sölve Elmståhl
  - Bengt Jeppsson
- PubMed: 38896223
- DOI: 10.1007/s12602-024-10310-7
4 Insights on
- High evidence
- Rigorous Journal
L-Citrulline Supplementation Improves Arterial Blood Flow and Muscle Oxygenation during Handgrip Exercise in Hypertensive Postmenopausal Women.
- 2024-06-19
- RCT
- Nutrients 16(12)
- - Yejin Kang
  - Katherine N Dillon
  - Mauricio A Martinez
  - Arun Maharaj
  - Stephen M Fischer
  - Arturo Figueroa
- PubMed: 38931289
- DOI: 10.3390/nu16121935
6 Insights on
- High evidence
- Rigorous Journal
A comprehensive review on nutritional, nutraceutical, and industrial perspectives of perilla (Perilla frutscens L.) seeds - An orphan oilseed crop.
- 2024-06-18
- Review
- Heliyon 10(12)
- - Simardeep Kaur
  - Karishma Seem
  - Ansheef Ali
  - Sandeep Jaiswal
  - Praveen Gumachanamardi
  - Gurkanwal Kaur
  - Naseeb Singh
  - Letngam Touthang
  - Sanjeev Kumar Singh
  - Rakesh Bhardwaj
  - Binay K Singh
  - Vinay Kumar Mishra
  - Amritbir Riar
- PubMed: 39022021
- DOI: 10.1016/j.heliyon.2024.e33281
8 Insights on
- Low evidence
Functional evaluation of pure natural edible Ferment: protective function on ulcerative colitis.
- 2024-06-17
- Frontiers in microbiology 15
- - Yanjun Chen
  - Shengzhi Ye
  - Jiaolong Shi
  - Hao Wang
  - Guangxu Deng
  - Guangxian Wang
  - Shijie Wang
  - Qingbin Yuan
  - Lunan Yang
  - Tingyu Mou
- PubMed: 38952444
- DOI: 10.3389/fmicb.2024.1367630
2 Insights on
- Improved Gut Microbiota Composition
- Reduced Ulcerative Colitis Symptoms
- Low evidence
Effects of different natural products in patients with non-alcoholic fatty liver disease-A network meta-analysis of randomized controlled trials.
- 2024-06-17
- Review · n = 2,509
- Phytotherapy research : PTR 38(7)
- - Hongshuai Liu
  - Yufei Li
  - Yan Jin
  - Xin Li
  - Dongxian Wang
  - Xiaowen Yu
  - Zhenyuan Jiang
  - Guoliang Yin
  - Suwen Chen
  - Xin Zhang
  - Decheng Meng
  - Wenfei Yu
  - Wenyin Jiang
  - Fengxia Zhang
- PubMed: 38886838
- DOI: 10.1002/ptr.8182
7 Insights on
- High evidence
Supplementing infant milk formula with a multi-strain synbiotic and osteopontin enhances colonic microbial colonization and modifies jejunal gene expression in lactating piglets.
- 2024-06-17
- Food & function 15(12)
- - Laia Ferreres-Serafini
  - Susana Mª Martín-Orúe
  - Meritxell Sadurní
  - Jesús Jiménez
  - José Antonio Moreno-Muñoz
  - Lorena Castillejos
- PubMed: 38807503
- DOI: 10.1039/d4fo00489b
1 Insight on
- Reduced Duration of Diarrhea
- Low evidence
- Rigorous Journal
The Role of Water-Soluble Vitamins and Vitamin D in Prevention and Treatment of Depression and Seasonal Affective Disorder in Adults.
- 2024-06-17
- Review
- Nutrients 16(12)
- - Alireza Jahan-Mihan
  - Priscilla Stevens
  - Saily Medero-Alfonso
  - Georgina Brace
  - Laurel Kate Overby
  - Kristin Berg
  - Corinne Labyak
- PubMed: 38931257
- DOI: 10.3390/nu16121902
2 Insights on
- Improved Depressive Symptoms
- Reduced Seasonal Affective Disorder Symptom
- Moderate evidence
- Rigorous Journal
Effects of Pycnogenol® in people with post-COVID-19 condition (PYCNOVID): study protocol for a single-center, placebo controlled, quadruple-blind, randomized trial.
- 2024-06-15
- RCT · n = 150
- Trials 25(1)
- - Thomas Radtke
  - Lisa Künzi
  - Julia Kopp
  - Manuela Rasi
  - Julia Braun
  - Kyra D Zens
  - Babette Winter
  - Alexia Anagnostopoulos
  - Milo A Puhan
  - Jan S Fehr
- PubMed: 38879571
- DOI: 10.1186/s13063-024-08187-6
13 Insights on
- High evidence
- Large Human Trial
Can Diet Alter the Intestinal Barrier Permeability in Healthy People? A Systematic Review.
- 2024-06-14
- Systematic Review
- Nutrients 16(12)
- - Daniele de Souza Marinho do Nascimento
  - Ana Carolina Costa Campos Mota
  - Maria Clara da Cruz Carvalho
  - Eva Débora de Oliveira Andrade
  - Érika Paula Silva Freitas de Oliveira
  - Liana Letícia Paulino Galvão
  - Bruna Leal Lima Maciel
- PubMed: 38931225
- DOI: 10.3390/nu16121871
1 Insight on
- Relieved Intestinal Impairments
- High evidence
- Rigorous Journal
Comparative study of choline alfoscerate as a combination therapy with donepezil: A mixed double-blind randomized controlled and open-label observation trial.
- 2024-06-14
- RCT · n = 119
- Medicine 103(24)
- - Wankiun Lee
  - Manho Kim
- PubMed: 38875437
- DOI: 10.1097/md.0000000000038067
3 Insights on
- High evidence
- Large Human Trial
Dietary supplementations to mitigate the cardiopulmonary effects of air pollution toxicity: A systematic review of clinical trials.
- 2024-06-13
- Systematic Review
- PloS one 19(6)
- - Mehran Ilaghi
  - Fatemeh Kafi
  - Mohadeseh Shafiei
  - Moein Zangiabadian
  - Mohammad Javad Nasiri
- PubMed: 38870164
- DOI: 10.1371/journal.pone.0304402
11 Insights on
- High evidence
The Effect of Local Application of Tea Tree Oil Adjunctive to Daily Oral Maintenance and Nonsurgical Periodontal Treatment: A Systematic Review and Meta-Analysis of Randomised Controlled Studies.
- 2024-06-12
- Meta-Analysis
- Oral health & preventive dentistry 22
- - Chenjiao Zhang
  - Bowen Liu
  - Jingchao Hu
  - Li Zhao
  - Han Zhao
- PubMed: 38864380
- DOI: 10.3290/j.ohpd.b5458585
3 Insights on
- High evidence
The Effect of Sargassum fusiforme and Fucus vesiculosus on Continuous Glucose Levels in Overweight Patients with Type 2 Diabetes Mellitus: A Feasibility Randomized, Double-Blind, Placebo-Controlled Trial.
- 2024-06-12
- RCT · n = 12
- Nutrients 16(12)
- - Karlijn A M Geurts
  - Sjoerd Meijer
  - Jeanine E Roeters van Lennep
  - Xi Wang
  - Behiye Özcan
  - Gardi Voortman
  - Hongbing Liu
  - Manuel Castro Cabezas
  - Kirsten A Berk
  - Monique T Mulder
- PubMed: 38931192
- DOI: 10.3390/nu16121837
1 Insight on
- Reduced Blood Glucose Levels
- High evidence
- Rigorous Journal