April 2023 Supplement Research Papers

• April 4

  • The Role of Next-Generation Probiotics in Obesity and Obesity-Associated Disorders: Current Knowledge and Future Perspectives

    • 2023-04-04
    • Review
    • International Journal of Molecular Sciences 24(7)
    • • N. Vallianou
      • D. Kounatidis
      • D. Tsilingiris
      • F. Panagopoulos
      • G. Christodoulatos
      • A. Evangelopoulos
      • I. Karampela
      • M. Dalamaga

    • PubMed: 37047729
    • DOI: 10.3390/ijms24076755

    2 Insights on

    • Improved Intestinal Microbiota
    • Improved Gut Flora Modulation

    • Low evidence

  • Effects of Lactobacillus Lactis Supplementation on Growth Performance, Hematological Parameters, Meat Quality and Intestinal Flora in Growing-Finishing Pigs

    • 2023-04-04
    • RCT
    • Animals 13(7)
    • • Haitao Duan
      • L. Lu
      • Lei Zhang
      • Jun Yu Li
      • X. Gu
      • Jun-guo Li

    • PubMed: 37048503
    • DOI: 10.3390/ani13071247

    2 Insights on

    • Improved Growth Performance
    • Improved Intestinal Flora

    • High evidence
• April 5

  • Carnosine and Beta-Alanine Supplementation in Human Medicine: Narrative Review and Critical Assessment.

    • 2023-04-05
    • Review
    • Nutrients 15(7)
    • • Ondrej Cesak
      • Jitka Vostalova
      • Ales Vidlar
      • Petra Bastlova
      • Vladimir Student

    • PubMed: 37049610
    • DOI: 10.3390/nu15071770

    13 Insights on

    • Improved Glycemic Control
    • Improved H Pylori Eradication Rates
    • Reduced Oral Mucositis Symptoms
    • Prevented Sarcopenia
    • Preserved Cognitive Abilities
    • Improved Neurodegenerative Disorder
    • Regressed Esophagitis
    • Improved Taste Function
    • Protected Gastrointestinal Mucosa
    • Reduced Cataract
    • Reduced Cardiovascular Disease
    • Improved Schizophrenia
    • Improved Autistic Disorder

    • Moderate evidence
    • Rigorous Journal
• April 11

  • Probiotics Influence Gut Microbiota and Tumor Immune Microenvironment to Enhance Anti-Tumor Efficacy of Doxorubicin.

    • 2023-04-11
    • Probiotics and antimicrobial proteins 16(2)
    • • Zixuan Ye
      • Lizhen Liang
      • Yuqiao Xu
      • Jingpeng Yang
      • Yanan Li

    • PubMed: 37040014
    • DOI: 10.1007/s12602-023-10073-7

    2 Insights on

    • Enhanced Natural Killer Cell Tumoricidal Activity
    • Improved Stress Tolerance

    • Low evidence
    • Rigorous Journal

  • Milk and Dairy Consumption and Its Relationship With Abundance of Lactobacillus crispatus in the Vaginal Microbiota: Milk Intake and Vaginal Lactobacillus

    • 2023-04-11
    • Observational · n = 516
    • Journal of Lower Genital Tract Disease 27(3)
    • • Gabriela B Moura
      • Márcia G Silva
      • C. Marconi

    • PubMed: 37043391
    • DOI: 10.1097/LGT.0000000000000736

    3 Insights on

    • Improved Stability of Gut Microbiota
    • Increased Abundance of Lactobacillus Crispatus
    • Improved Infection Protection

    • High evidence

  • Effects of the probiotic Lactiplantibacillus plantarum IMC 510® on body composition, biochemical parameters, gut microbiota composition and function, and clinical symptoms of overweight/obese subjects

    • 2023-04-11
    • RCT · n = 40
    • Frontiers in Nutrition 10
    • • G. Pagliai
      • M. Coman
      • S. Baldi
      • M. Dinu
      • G. Nannini
      • E. Russo
      • Lavinia Curini
      • B. Colombini
      • S. Lotti
      • M. Pallecchi
      • L. Di Gloria
      • G. Bartolucci
      • M. Ramazzotti
      • M. Verdenelli
      • F. Sofi
      • A. Amedei

    • PubMed: 37125045
    • DOI: 10.3389/fnut.2023.1142527

    12 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Waist-to-Height Ratio
    • Reduced Gastrointestinal Symptoms
    • Reduced Body Weight
    • Improved Blood Glucose Levels
    • Increased Beneficial Gut Microbiota
    • Reduced Serum Glucose Levels
    • Decreased Hafnia-Obesumbacterium Genus
    • Reduced Genera Romboutsia
    • Improved Gut Microbiome Composition
    • Reduced Pro-Inflammatory Fatty Acids

    • High evidence
• April 12

  • The effects of rice bran supplementation for management of blood lipids: A GRADE-assessed systematic review, dose-response meta-analysis, and meta-regression of randomized controlled trials.

    • 2023-04-12
    • Meta-Analysis
    • Systematic reviews 12(1)
    • • Zahra Hariri
      • Fatemeh Afzalzade
      • Golbon Sohrab
      • Saeede Saadati
      • Zahra Yari

    • PubMed: 37046340
    • DOI: 10.1186/s13643-023-02228-y

    4 Insights on

    • Reduced Low-Density Lipoprotein Level
    • Reduced Triglyceride Levels
    • Increased HDL Cholesterol Levels
    • Reduced Total Cholesterol

    • High evidence
• April 14

  • Impact of Lactobacillus crispatus-containing oral and vaginal probiotics on vaginal health: a randomised double-blind placebo controlled clinical trial.

    • 2023-04-14
    • RCT · n = 182
    • Beneficial Microbes 14(2)
    • • R. Mändar
      • G. Sõerunurk
      • J. Štšepetova
      • I. Smidt
      • T. Rööp
      • S. Kõljalg
      • M. Saare
      • K. Ausmees
      • D. D. Le
      • M. Jaagura
      • S. Piiskop
      • H. Tamm
      • A. Salumets

    • PubMed: 36856121
    • DOI: 10.3920/BM2022.0091

    6 Insights on

    • Improved Symptoms of Bacterial Vaginosis
    • Improved Vaginal Health
    • Reduced Symptoms in VVC Patients
    • Increased Vaginal Lactobacilli
    • Reduced Vaginal Candidiasis Symptoms
    • Reduced VVC Symptoms

    • High evidence

  • Heat-killed Lactobacillus helveticus improves mood states: a randomised, double-blind, placebo-controlled study.

    • 2023-04-14
    • RCT · n = 58
    • Beneficial Microbes 14(2)
    • • N. Mutoh
      • I. Kakiuchi
      • A. Hiraku
      • N. Iwabuchi
      • K. Kiyosawa
      • K. Igarashi
      • M. Tanaka
      • M. Nakamura
      • M. Miyasaka

    • PubMed: 37026368
    • DOI: 10.3920/BM2022.0048

    14 Insights on

    • Improved Positive Mood States
    • Ensured Safety for Human Consumption
    • No Adverse Health Effects
    • Improved Sleep Quality
    • Reduced Fatigue Levels
    • No Change in Negative Mood States
    • No Change in Sleep Quality
    • No Significant Effect on Negative Mood States
    • Reduced Negative Mood States
    • Improved Relaxation
    • No Significant Change in Fatigue
    • No Observed Adverse Effects
    • No Impact on Negative Mood States
    • No Impact on Fatigue

    • High evidence

  • Evaluation of Bacillus clausii CSI08, Bacillus megaterium MIT411 and a Bacillus cocktail on gastrointestinal health: a randomised, double-blind, placebo-controlled pilot study.

    • 2023-04-14
    • RCT · n = 98
    • Beneficial Microbes 14(2)
    • • K. Rea
      • J. Colom
      • E. A. Simon
      • E. Khokhlova
      • S. Mazhar
      • M. Barrena
      • M. Enrique
      • P. Martorell
      • B. Perez
      • M. Tortajada
      • C. Phipps
      • J. Deaton

    • PubMed: 37026366
    • DOI: 10.3920/BM2022.0117

    5 Insights on

    • Reduced Incidence of Loose Stools
    • Maintained Gut Microbiota Diversity
    • Stable Blood Parameters
    • No Change in Mood
    • No Change in Inflammatory Cytokines

    • High evidence
• April 18

  • Antiobesity Effect of Lacticaseibacillus paracasei LM-141 on High-Fat Diet-Induced Rats through Alleviation of Inflammation and Insulin Resistance

    • 2023-04-18
    • Clinical Trial
    • Evidence-Based Complementary and Alternative Medicine 2023
    • • Ching-Shuang Wu
      • Chih-Chieh Lin
      • Feng-Ching Hsieh
      • Tai-Yun Wu
      • Ai-Hui Fang

    • PubMed: 37114144
    • DOI: 10.1155/2023/1011591

    7 Insights on

    • Improved Insulin Sensitivity
    • Reduced Inflammation Levels
    • Improved Lipid Profile
    • Reduced Hepatic Steatosis
    • Reduced Weight Gain
    • Induction of Browning of White Adipose Tissue
    • Preserved Liver Function

    • Low evidence
    • Animal Study
• April 25

  • Effects of Probiotic Supplementation on Exercise and the Underlying Mechanisms.

    • 2023-04-25
    • Review
    • Foods (Basel, Switzerland) 12(9)
    • • Li Zhang
      • Ruhao Zhang
      • Lu Li

    • PubMed: 37174325
    • DOI: 10.3390/foods12091787

    3 Insights on

    • Improved Stress Response
    • Improved Motor Function
    • Improved Exercise Function

    • Low evidence
• April 26

  • Restorative effects of Lactobacillus rhamnosus LR-32 on the gut microbiota, barrier integrity, and 5-HT metabolism in reducing feather-pecking behavior in laying hens with antibiotic-induced dysbiosis

    • 2023-04-26
    • Clinical Trial
    • Frontiers in Microbiology 14
    • • Chen-xuan Huang
      • Qiao-xian Yue
      • Li Sun
      • K. Di
      • D. Yang
      • E. Hao
      • De-He Wang
      • Yi-fan Chen
      • Lei Shi
      • Rong-Yan Zhou
      • Guoxian Zhao
      • Hui Chen

    • PubMed: 37180262
    • DOI: 10.3389/fmicb.2023.1173804

    4 Insights on

    • Improved Gut Integrity
    • Restored Gut Microbiome Balance
    • Reduced Severe Feather-Pecking Behavior
    • Improved Serotonin Metabolism

    • Low evidence
    • Animal Study
• April 27

  • Application of Lactobacillus reuteri B1/1 (Limosilactobacillus reuteri) Improves Immunological Profile of the Non-Carcinogenic Porcine-Derived Enterocytes

    • 2023-04-27
    • Life 13(5)
    • • V. Karaffová
      • J. Teleky
      • Maša Pintarič
      • T. Langerholc
      • D. Mudroňová
      • Erik Hudec
      • Z. Ševčíková

    • PubMed: 37240735
    • DOI: 10.3390/life13051090

    3 Insights on

    • Increased Pro-inflammatory Cytokine Release
    • Improved Metabolic Function
    • Improved Adherence Ability

    • Low evidence
• April 29

  • Update on the treatment of chemotherapy and radiotherapy-induced buccal mucositis: a systematic review.

    • 2023-04-29
    • Systematic Review
    • Acta odontologica latinoamericana : AOL 36(1)
    • • Schilin Wen
      • Leonardo Brito
      • Javiera Santander
      • Gonzalo Conteras

    • PubMed: 37314054
    • DOI: 10.54589/aol.36/1/3

    1 Insight on

    • Reduced Oral Mucositis Severity

    • High evidence
• April 30

  • Total Transit Time and Probiotic Persistence in Healthy Adults: A Pilot Study.

    • 2023-04-30
    • Clinical Trial · n = 13
    • Journal of neurogastroenterology and motility 29(2)
    • • Annie Tremblay
      • Jeremie Auger
      • Zainab Alyousif
      • Sara E Caballero Calero
      • Olivier Mathieu
      • Daniela Rivero-Mendoza
      • Amal Elmaoui
      • Wendy J Dahl
      • Thomas A Tompkins

    • PubMed: 37019866
    • DOI: 10.5056/jnm22031

    1 Insight on

    • Increased Persistence of Probiotics in Fecal Matter

    • Moderate evidence
• Undated – 1 supplement study

  • Safety and efficacy of a feed additive consisting of Lactiplantibacillus plantarum DSM 11520 for horses, dogs, cats and pet rabbits (Animal Probiotics Sweden AB)

    • 2023-04
    • EFSA Journal 21(4)
    • • V. Bampidis
      • G. Azimonti
      • M. Bastos
      • Henrik Christensen
      • B. Dusemund
      • M. Durjava
      • M. Kouba
      • M. López-Alonso
      • Secundino López Puente
      • F. Marcon
      • B. Mayo
      • A. Pechová
      • M. Petkova
      • F. Ramos
      • Yolanda Sanz
      • R. Villa
      • R. Woutersen
      • M. Anguita
      • Rosella Brozzi
      • J. Galobart
      • M. Innocenti
      • Y. García‐Cazorla

    • PubMed: 37089175
    • DOI: 10.2903/j.efsa.2023.7974

    3 Insights on

    • Reduced Faecal pH
    • Reduced Skin and Eye Irritation
    • Increased Respiratory Sensitization

    • Low evidence