October 2023 Supplement Research Papers

• October 1

  • Unique Properties of Yeast Probiotic Saccharomyces boulardii CNCM I-745: A Narrative Review.

    • 2023-10-01
    • Review
    • Cureus 15(10)
    • • Sarath Gopalan
      • Sridhar Ganapathy
      • Monjori Mitra
      • Neha
      • Devesh Kumar Joshi
      • Krishna C Veligandla
      • Rahul Rathod
      • Bhavesh P Kotak

    • PubMed: 37927652
    • DOI: 10.7759/cureus.46314

    3 Insights on

    • Reduced Duration of Diarrhea
    • Reduced Diarrhea Rate
    • Reduced Length of Hospital Stay

    • Low evidence

  • Quercetin in Sports and Exercise: A review.

    • 2023-10-01
    • Review · n = 34
    • International journal of exercise science 16(2)
    • • Jennifer A Kurtz
      • Trisha A Vandusseldorp
      • Brent Uken
      • Jeff Otis

    • PubMed: 38288402
    • DOI: 10.70252/gqok2958

    12 Insights on

    • Reduced Inflammatory Markers
    • Reduced Lipid Peroxidation
    • Reduced C-Reactive Protein Levels
    • Reduced Muscle Damage
    • Reduced Lactate Dehydrogenase Level
    • Reduced Creatine Kinase Level
    • Improved Time to Exhaustion
    • Improved VO2max
    • Reduced Fatigue Decrement
    • Improved Neuromuscular Function
    • Improved Redox Potential
    • Improved Repeated Sprint Performance

    • Moderate evidence

  • Effects of acute beta-alanine supplementation on post-exertion rating of per-ceived exertion, heart rate, blood lactate, and physical performance on the 6-minute race test in middle-distance runners.

    • 2023-10-01
    • RCT
    • Nutricion hospitalaria 40(5)
    • • Guillermo Barahona-Fuentes
      • Álvaro Huerta Ojeda
      • Sergio Galdames Maliqueo
      • María-Mercedes Yeomans-Cabrera
      • Carlos Jorquera Aguilera

    • PubMed: 37073742
    • DOI: 10.20960/nh.04432

    4 Insights on

    • Improved Physical Performance
    • Increased Blood Lactate Levels
    • Reduced Heart Rate
    • Reduced Perceived Exertion

    • High evidence
• October 2

  • A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab.

    • 2023-10-02
    • RCT
    • Diabetologia 67(1)
    • • Chantal Mathieu
      • Alice Wiedeman
      • Karen Cerosaletti
      • S Alice Long
      • Elisavet Serti
      • Laura Cooney
      • Joan Vermeiren
      • Silvia Caluwaerts
      • Karolien Van Huynegem
      • Lothar Steidler
      • Sven Blomme
      • Pieter Rottiers
      • Gerald T Nepom
      • Kevan C Herold

    • PubMed: 37782353
    • DOI: 10.1007/s00125-023-06014-2

    2 Insights on

    • Improved Metabolic Control in Type 1 Diabetes
    • Reduced Preproinsulin-Specific CD8+ T-Cell Frequency

    • High evidence
• October 3

  • Efficacy and safety of Ophiocordyceps sinensis in the treatment of Hashimoto's thyroiditis: a systematic review and meta-analysis.

    • 2023-10-03
    • Systematic Review · n = 14
    • Frontiers in pharmacology 14
    • • Maoying Wei
      • Wenxin Ma
      • Wenhua Zhang
      • Dan Yin
      • Yiting Tang
      • Weiyu Jia
      • Yijia Jiang
      • Churan Wang
      • Yanbing Gong

    • PubMed: 37854714
    • DOI: 10.3389/fphar.2023.1272124

    7 Insights on

    • Reduced Waist-to-Height Ratio
    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Interleukin-6 Levels
    • Increased Serum Free Thyroxine Levels
    • Increased Free Triiodothyronine Level
    • Reduced Thyroid Peroxidase Antibody Level
    • Reduced Thyroglobulin Antibody Level

    • High evidence

  • CHronic hypERtension and L-citRulline studY (CHERRY): an Early-Phase Randomised Controlled Trial in Pregnancy.

    • 2023-10-03
    • RCT · n = 24
    • Reproductive sciences (Thousand Oaks, Calif.) 31(2)
    • • Laura Ormesher
      • Stephanie A Worton
      • Ashley Best
      • Susanna R Dodd
      • Alice Dempsey
      • Elizabeth C Cottrell
      • Heather Glossop
      • Catherine Chmiel
      • Hoi Yee Wu
      • Ben Hardwick
      • Sophie Hennessy
      • Edward D Johnstone
      • Jenny E Myers

    • PubMed: 37789125
    • DOI: 10.1007/s43032-023-01335-4

    4 Insights on

    • Reduced Diastolic Blood Pressure
    • Improved Uterine Artery Doppler Parameter
    • Improved Angiogenic Biomarker
    • Improved Arginine to Asymmetric Dimethylarginine Ratio

    • High evidence

  • The effects of NAD+ precursor (nicotinic acid and nicotinamide) supplementation on weight loss and related hormones: a systematic review and meta-regression analysis of randomized controlled trials.

    • 2023-10-03
    • Systematic Review · n = 144
    • Frontiers in nutrition 10
    • • You Baichuan
      • Marcela Gomes Reis
      • Sogand Tavakoli
      • Navideh Khodadadi
      • Mohammad Hassan Sohouli
      • Nathalia Sernizon Guimarães

    • PubMed: 37854354
    • DOI: 10.3389/fnut.2023.1208734

    4 Insights on

    • Reduced Body Mass Index
    • Reduced Leptin Levels
    • Reduced Body Weight
    • Increased Adiponectin Levels

    • High evidence

  • Lactobacillus (Limosilactobacillus) reuteri: a probiotic candidate to reduce neonatal diarrhea in calves

    • 2023-10-03
    • RCT
    • Frontiers in Microbiology 14
    • • K. Schwaiger
      • J. Storch
      • Christoph Bauer
      • Johann Bauer

    • PubMed: 37854332
    • DOI: 10.3389/fmicb.2023.1266905

    1 Insight on

    • Reduced Diarrhea Incidence

    • High evidence
• October 5

  • Review and Perspectives on Bifidobacterium lactis for Infants' and Children's Health.

    • 2023-10-05
    • Review
    • Microorganisms 11(10)
    • • Annie Tremblay
      • Stéphane Bronner
      • Sylvie Binda

    • PubMed: 37894159
    • DOI: 10.3390/microorganisms11102501

    4 Insights on

    • Improved Intestinal Health
    • Reduced Risk of Infant Health Problems
    • Improved Infant Gut Microbiota Restoration
    • Improved Infant Health

    • Low evidence

  • Maternal supplementation with Limosilactobacillus reuteri FN041 for preventing infants with atopic dermatitis: study protocol for a randomized controlled trial

    • 2023-10-05
    • RCT · n = 840
    • Frontiers in Microbiology 14
    • • Renqiang Yu
      • Yizhe Ma
      • Zichen Luo
      • Ce Qi
      • Anni Xie
      • Yifan Jiang
      • Baoli Zhu
      • Jin Sun

    • PubMed: 37869669
    • DOI: 10.3389/fmicb.2023.1267448

    1 Insight on

    • Reduced Incidence of Atopic Dermatitis

    • High evidence
    • Large Human Trial
• October 6

  • Effects of supplementation with milk protein on glycemic parameters: a GRADE-assessed systematic review and dose-response meta-analysis.

    • 2023-10-06
    • Meta-Analysis · n = 1,851
    • Nutrition journal 22(1)
    • • Shooka Mohammadi
      • Omid Asbaghi
      • Sina Dolatshahi
      • Hossein Salehi Omran
      • Niusha Amirani
      • Fatemeh Jahangir Koozehkanani
      • Hossein Bagherzadeh Garmjani
      • Kian Goudarzi
      • Damoon Ashtary-Larky

    • PubMed: 37798798
    • DOI: 10.1186/s12937-023-00878-1

    4 Insights on

    • Reduced Insulin Levels
    • Reduced Hemoglobin A1c
    • Reduced Fasting Blood Glucose Levels
    • Reduced HOMA-IR

    • High evidence
• October 9

  • Superoxide dismutase for bronchopulmonary dysplasia in preterm infants.

    • 2023-10-09
    • Systematic Review · n = 380
    • The Cochrane database of systematic reviews 2023(10)
    • • Martina Albertella
      • Rahul R Gentyala
      • Themistoklis Paraskevas
      • Danielle Ehret
      • Matteo Bruschettini
      • Roger Soll

    • PubMed: 37811631
    • DOI: 10.1002/14651858.cd013232.pub2

    4 Insights on

    • Reduced Mortality Rate
    • Reduced Bronchopulmonary Dysplasia
    • Reduced Neonatal Mortality
    • Reduced Retinopathy of Prematurity

    • High evidence
• October 10

  • Effect of single or combined caffeine and L-Theanine supplementation on shooting and cognitive performance in elite curling athletes: a double-blind, placebo-controlled study.

    • 2023-10-10
    • RCT
    • Journal of the International Society of Sports Nutrition 20(1)
    • • Umut Yilmaz
      • Yusuf Buzdagli
      • Muhammed Lütfü Polat
      • Yusuf Bakir
      • Burak Ozhanci
      • Sena Alkazan
      • Halil Ucar

    • PubMed: 37815006
    • DOI: 10.1080/15502783.2023.2267536

    11 Insights on

    • Improved Attention Span
    • Improved Reaction Time
    • Improved Guard Shot Performance
    • Improved Draw Shot Performance
    • Improved Take-out Shot Performance
    • Improved Shot Performance
    • Improved Reaction Time on Incongruent Stroop Task
    • Reduced Error Rate on Neutral Stroop Task
    • Reduced Error Rate
    • Reduced Error Rate on Congruent Stroop Task
    • Reduced Incongruent Stroop Task Error Rate

    • High evidence

  • Cocoa Extract Supplementation and Risk of Type 2 Diabetes: The Cocoa Supplement and Multivitamin Outcomes Study (COSMOS) Randomized Clinical Trial.

    • 2023-10-10
    • RCT · n = 776
    • Diabetes care 46(12)
    • • Jie Li
      • Howard D Sesso
      • Eunjung Kim
      • JoAnn E Manson
      • Georgina Friedenberg
      • Allison Clar
      • Trisha Copeland
      • Aladdin H Shadyab
      • Jean Wactawski-Wende
      • Lesley Tinker
      • Simin Liu

    • PubMed: 37816167
    • DOI: 10.2337/dc23-1012

    1 Insight on

    • Reduced Incidence of Type 2 Diabetes

    • High evidence
    • Large Human Trial
• October 12

  • Ligilactobacillus salivarius 7247 Strain: Probiotic Properties and Anti-Salmonella Effect with Prebiotics.

    • 2023-10-12
    • Antibiotics (Basel, Switzerland) 12(10)
    • • Vyacheslav M Abramov
      • Igor V Kosarev
      • Andrey V Machulin
      • Evgenia I Deryusheva
      • Tatiana V Priputnevich
      • Alexander N Panin
      • Irina O Chikileva
      • Tatiana N Abashina
      • Ashot M Manoyan
      • Anna A Ahmetzyanova
      • Olga E Ivanova
      • Tigran T Papazyan
      • Ilia N Nikonov
      • Nataliya E Suzina
      • Vyacheslav G Melnikov
      • Valentin S Khlebnikov
      • Vadim K Sakulin
      • Vladimir A Samoilenko
      • Alexey B Gordeev
      • Gennady T Sukhikh
      • Vladimir N Uversky

    • PubMed: 37887236
    • DOI: 10.3390/antibiotics12101535

    3 Insights on

    • Reduced Salmonella typhimurium Adhesion
    • Reduced Pathogenic Bacterial Growth
    • Reduced Salmonella Activity

    • Low evidence

  • The Use of Fibers, Herbal Medicines and Spices in Children with Irritable Bowel Syndrome: A Narrative Review.

    • 2023-10-12
    • Review
    • Nutrients 15(20)
    • • Daniela Pop
      • Radu Samuel Pop
      • Dorin Farcău

    • PubMed: 37892426
    • DOI: 10.3390/nu15204351

    1 Insight on

    • Reduced Irritable Bowel Syndrome Symptoms

    • Moderate evidence
    • Rigorous Journal
• October 13

  • Limosilactobacillus reuteri DSM 17938 as a probiotic in preterm infants: An updated systematic review with meta-analysis and trial sequential analysis.

    • 2023-10-13
    • Meta-Analysis · n = 2,284
    • JPEN. Journal of parenteral and enteral nutrition 47(8)
    • • Ju Li Ang
      • Gayatri Athalye-Jape
      • Shripada Rao
      • Max Bulsara
      • Sanjay Patole

    • PubMed: 37742098
    • DOI: 10.1002/jpen.2564

    4 Insights on

    • Reduced All-Cause Mortality
    • Reduced Time to Reach Full Feeds
    • Reduced Late-Onset Sepsis
    • Reduced Necrotizing Enterocolitis Stage II

    • High evidence
• October 18

  • Pre-medication with simethicone and N-acetyl cysteine for improving mucosal visibility during upper gastrointestinal endoscopy: A randomized controlled trial.

    • 2023-10-18
    • RCT · n = 800
    • Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 43(5)
    • • Zaheer Nabi
      • Mohan Vamsi
      • Rajesh Goud
      • Mahiboob Sayyed
      • Jahangeer Basha
      • Palle Manohar Reddy
      • Rithesh Reddy
      • Praveen Reddy
      • Chaithanya Manchu
      • Santosh Darisetty
      • Rajesh Gupta
      • Manu Tandan
      • Guduru Venkat Rao
      • D Nageshwar Reddy

    • PubMed: 37848768
    • DOI: 10.1007/s12664-023-01459-0

    2 Insights on

    • Improved Mucosal Visibility
    • Increased Lesion Detection Rate

    • High evidence
    • Large Human Trial
• October 20

  • Health Benefits of Bread Fortification: A Systematic Review of Clinical Trials according to the PRISMA Statement.

    • 2023-10-20
    • Systematic Review
    • Nutrients 15(20)
    • • Urszula Kaim
      • Zuzanna Sabina Goluch

    • PubMed: 37892534
    • DOI: 10.3390/nu15204459

    8 Insights on

    • Improved Immune Function
    • Reduced Blood Pressure
    • Reduced Oxidative Stress
    • Improved Vitamin D Levels
    • Improved Glycemia
    • Improved Iron Status
    • Increased Bone Mineral Density
    • Reduced Homocysteine Level

    • High evidence
    • Rigorous Journal
• October 26

  • Effects of Flavonoid Supplementation on Athletic Performance in Healthy Adults: A Systematic Review and Meta-Analysis.

    • 2023-10-26
    • Meta-Analysis · n = 22
    • Nutrients 15(21)
    • • Ying Wang
      • Zhuang Tian
      • Zhenyu Li
      • Jae Cheol Kim

    • PubMed: 37960199
    • DOI: 10.3390/nu15214547

    2 Insights on

    • Improved Athletic Performance
    • Improved Exercise Tolerance

    • High evidence
    • Rigorous Journal

  • Effect of Lactobacillus kefiri, in Conjunction with PENS T6 and a Hypocaloric Diet, on Weight Loss, Hypertension and Laboratory Glycemic and Lipid Profile

    • 2023-10-26
    • RCT
    • Nutrients 15(21)
    • • Jaime Ruiz-Tovar
      • C. Llavero
      • M. Fernández-Contreras

    • PubMed: 37960202
    • DOI: 10.3390/nu15214549

    8 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Body Weight
    • Improved Lipid Profile
    • Increased Weight Reduction
    • Improved Glycemic Control
    • Improved Gut Microbiome Composition
    • Improved Blood Lipid Profile
    • Increased Weight Loss

    • High evidence
• October 27

  • Eight Weeks of Bifidobacterium lactis BL-99 Supplementation Improves Lipid Metabolism and Sports Performance through Short-Chain Fatty Acids in Cross-Country Skiers: A Preliminary Study

    • 2023-10-27
    • RCT · n = 16
    • Nutrients 15(21)
    • • Tie-hui Li
      • Zihan Rui
      • Letian Mao
      • Yashan Chang
      • Jing Shao
      • Yue Chen
      • Qi Han
      • Xuemi Sui
      • Nan An
      • Haoqiu Li
      • Haotian Feng
      • Tao Jiang
      • Qirong Wang

    • PubMed: 37960207
    • DOI: 10.3390/nu15214554

    10 Insights on

    • Improved Lipid Metabolism
    • Reduced LDL Cholesterol
    • Increased Short-Chain Fatty Acid Production
    • Improved Exercise Performance
    • Increased Beneficial Gut Bacteria
    • Increased Abundance of Bifidobacterium animalis
    • Improved VO2 Max
    • Improved Knee Joint Extensor Strength
    • Reduced Bile Acid Levels
    • Improved Sports Performance

    • High evidence
• October 28

  • Postbiotic Fractions of Probiotics Lactobacillus plantarum 299v and Lactobacillus rhamnosus GG Show Immune-Modulating Effects.

    • 2023-10-28
    • Cells 12(21)
    • • Agnieszka Magryś
      • Mateusz Pawlik

    • PubMed: 37947616
    • DOI: 10.3390/cells12212538

    5 Insights on

    • Reduced Intestinal Inflammation
    • Maintained Intestinal Barrier Function
    • Increased Anti-Inflammatory Cytokine IL-10
    • Maintained Intestinal Barrier Integrity
    • Modulated IL-18-Related Immune Response

    • Low evidence

  • Prebiotics, Probiotics, and Synbiotics-A Research Hotspot for Pediatric Obesity.

    • 2023-10-28
    • Review
    • Microorganisms 11(11)
    • • Reka Borka Balas
      • Lorena Elena Meliț
      • Ancuța Lupu
      • Vasile Valeriu Lupu
      • Cristina Oana Mărginean

    • PubMed: 38004665
    • DOI: 10.3390/microorganisms11112651

    3 Insights on

    • Reduced Body Mass Index
    • Improved Glucose Metabolism
    • Improved Blood Lipid Content

    • Low evidence
• October 30

  • Invertebrate C1q Domain-Containing Proteins: Molecular Structure, Functional Properties and Biomedical Potential.

    • 2023-10-30
    • Review
    • Marine drugs 21(11)
    • • Andrei Grinchenko
      • Ivan Buriak
      • Vadim Kumeiko

    • PubMed: 37999394
    • DOI: 10.3390/md21110570

    1 Insight on

    • No Human Health Outcome Reported

    • Low evidence
• October 31

  • Systematic review and meta-analysis: Foods, drinks and diets and their effect on chronic constipation in adults.

    • 2023-10-31
    • Meta-Analysis · n = 1,714
    • Alimentary pharmacology & therapeutics 59(2)
    • • Alice Van Der Schoot
      • Zoi Katsirma
      • Kevin Whelan
      • Eirini Dimidi

    • PubMed: 37905980
    • DOI: 10.1111/apt.17782

    1 Insight on

    • Improved Bowel Movement Frequency

    • High evidence
    • Rigorous Journal
• Undated – 7 supplement studies

  • Relieving psychological stress and improving sleep quality by bergamot essential oil use before bedtime and upon awakening: A randomized crossover trial.

    • 2023-10
    • RCT · n = 48
    • Complementary therapies in medicine 77
    • • Nobuyuki Wakui
      • Chikako Togawa
      • Kotoha Ichikawa
      • Raini Matsuoka
      • Mai Watanabe
      • Aika Okami
      • Shunsuke Shirozu
      • Miho Yamamura
      • Yoshiaki Machida

    • PubMed: 37625623
    • DOI: 10.1016/j.ctim.2023.102976

    5 Insights on

    • Reduced Depression Symptoms
    • Reduced Anxiety
    • Improved Sleep Quality
    • Reduced Stress
    • Improved Sleep Length

    • High evidence

  • Combined use of total glucosides of paeony and hydroxychloroquine in primary Sjögren's syndrome: A systematic review.

    • 2023-10
    • Meta-Analysis · n = 632
    • Immunity, inflammation and disease 11(10)
    • • Aiping Zhang
      • Shilei Chen
      • Riyang Lin

    • PubMed: 37904705
    • DOI: 10.1002/iid3.1044

    8 Insights on

    • Increased Immunoglobulin G Levels
    • Increased Serum Immunoglobulin A (IgA) Levels
    • Reduced Erythrocyte Sedimentation Rate
    • Increased Salivary Flow Rate
    • Improved Dry Mouth Resolution
    • Improved Dry Eye Resolution
    • Improved Tear Secretion
    • Reduced Immunoglobulin M Level

    • High evidence

  • 5-MTHF enhances the portal pressure reduction achieved with propranolol in patients with cirrhosis: A randomized placebo-controlled trial.

    • 2023-10
    • RCT
    • Journal of hepatology 79(4)
    • • Ranka Vukotic
      • Roberto Di Donato
      • Greta Roncarati
      • Patrizia Simoni
      • Matteo Renzulli
      • Stefano Gitto
      • Filippo Schepis
      • Erica Villa
      • Annalisa Berzigotti
      • Jaume Bosch
      • Pietro Andreone

    • PubMed: 37482222
    • DOI: 10.1016/j.jhep.2023.06.017

    5 Insights on

    • Reduced Homocysteine Level
    • Reduced Hepatic Venous Pressure Gradient
    • Increased Tetrahydrobiopterin Level
    • Reduced Asymmetric Dimethylarginine Level
    • Changed Hepatic Blood Flow

    • High evidence

  • Efficacy and safety of Lacticaseibacillus paracasei Lpc-37® in students facing examination stress: A randomized, triple-blind, placebo-controlled clinical trial (the ChillEx study).

    • 2023-10
    • RCT
    • Brain, behavior, & immunity - health 32
    • • Sanna M Mäkelä
      • Síle M Griffin
      • Jenni Reimari
      • Kara C Evans
      • Ashley A Hibberd
      • Nicolas Yeung
      • Alvin Ibarra
      • Jouni Junnila
      • Jari Turunen
      • Ronnie Beboso
      • Balgit Chhokar
      • Timothy G Dinan
      • John Cryan
      • Elaine Patterson

    • PubMed: 37662485
    • DOI: 10.1016/j.bbih.2023.100673

    4 Insights on

    • Reduced Circadian Sleep Disturbance
    • Reduced Sleep Duration
    • Reduced Alertness
    • No Reduction in Stress or Anxiety

    • High evidence

  • Probiotic-related Clostridium butyricum bacteremia: a case report and literature review.

    • 2023-10
    • Review
    • Anaerobe 83
    • • Kazuhiro Ishikawa
      • Ryo Hasegawa
      • Koko Shibutani
      • Yumiko Mikami
      • Fujimi Kawai
      • Takahiro Matsuo
      • Yuki Uehara
      • Nobuyoshi Mori

    • PubMed: 37544356
    • DOI: 10.1016/j.anaerobe.2023.102770

    1 Insight on

    • Reduced Bacteremia

    • Low evidence

  • Effects of Synbiotic-Containing Bacillus coagulans (GBI-30) on the Cardiovascular Status of Patients With Polycystic Ovary Syndrome: A Triple-blinded, Randomized, Placebo-controlled Study.

    • 2023-10
    • RCT · n = 72
    • Clinical therapeutics 45(10)
    • • Zahra Hariri
      • Zahra Yari
      • Sedighe Hoseini
      • Afsaneh Mehrnami
      • Khadijeh Abhari
      • Golbon Sohrab

    • PubMed: 37640616
    • DOI: 10.1016/j.clinthera.2023.07.024

    3 Insights on

    • Reduced Atherogenic Index
    • Reduced C-Reactive Protein Levels
    • Improved Blood Lipid Profile

    • High evidence

  • Ayurvedic and herbal plaque control agents in gingivitis: A systematic review and meta-analysis of randomized controlled trials.

    • 2023-10
    • Review · n = 806
    • Journal of education and health promotion 12(1)
    • • Danish Javed
      • Ashish Kumar Dixit
      • Sana Anwar
      • Anshul Rai
      • Kawal Krishan

    • PubMed: 38144032
    • DOI: 10.4103/jehp.jehp_204_23

    1 Insight on

    • Reduced Plaque Index

    • High evidence