December 2023 Supplement Research Papers

• December 4

  • Adhatoda vasica and Tinospora cordifolia extracts ameliorate clinical and molecular markers in mild COVID-19 patients: a randomized open-label three-armed study.

    • 2023-12-04
    • RCT · n = 150
    • European journal of medical research 28(1)
    • • Mukta Verma
      • Neha Rawat
      • Ritu Rani
      • Manju Singh
      • Aditi Choudhary
      • Sarfaraz Abbasi
      • Manish Kumar
      • Sachin Kumar
      • Ankur Tanwar
      • Bishnu Raman Misir
      • Sangeeta Khanna
      • Anurag Agrawal
      • Mohammed Faruq
      • Shalini Rai
      • Richa Tripathi
      • Anil Kumar
      • Mukta Pujani
      • Meera Bhojani
      • Anil Kumar Pandey
      • Tanuja Nesari
      • Bhavana Prasher

    • PubMed: 38049897
    • DOI: 10.1186/s40001-023-01507-7

    11 Insights on

    • Reduced Body Temperature
    • Increased Eosinophil Count
    • Reduced Aspartate Aminotransferase Level
    • Reduced Viral Clearance Time
    • Increased PT/INR
    • Reduced Monocyte Count
    • Reduced Globulin Level
    • Reduced Ferritin Level
    • Reduced HIF-1α Level
    • Reduced hsCRP Level
    • Reduced MCP-3 Level

    • High evidence
    • Large Human Trial
• December 5

  • Research protocol of the efficacy of probiotics for the treatment of alcohol use disorder among adult males: A comparison with placebo and acceptance and commitment therapy in a randomized controlled trial.

    • 2023-12-05
    • RCT
    • PloS one 18(12)
    • • Bingyu Zhang
      • Ruiling Zhang
      • Hongdu Deng
      • Ping Cui
      • Chunyan Li
      • Fan Yang
      • Mohammad Farris Iman Leong Bin Abdullah

    • PubMed: 38051740
    • DOI: 10.1371/journal.pone.0294768

    1 Insight on

    • Reduced Pro-inflammatory Cytokine Levels

    • High evidence

  • Agrocybe aegerita Polysaccharide Combined with Bifidobacterium lactis Bb-12 Attenuates Aging-Related Oxidative Stress and Restores Gut Microbiota.

    • 2023-12-05
    • Foods (Basel, Switzerland) 12(24)
    • • Xiaoyan Liu
      • Yanyu Feng
      • Hongmin Zhen
      • Lina Zhao
      • Hongqiang Wu
      • Bin Liu
      • Guangsen Fan
      • Aijun Tong

    • PubMed: 38137185
    • DOI: 10.3390/foods12244381

    3 Insights on

    • Improved Gut Microbiota Composition
    • Improved Oxidative Stress Resistance
    • Reduced Aging Effects

    • Low evidence
• December 6

  • Gut liver brain axis in diseases: the implications for therapeutic interventions.

    • 2023-12-06
    • Review
    • Signal transduction and targeted therapy 8(1)
    • • Mengyao Yan
      • Shuli Man
      • Benyue Sun
      • Long Ma
      • Lanping Guo
      • Luqi Huang
      • Wenyuan Gao

    • PubMed: 38057297
    • DOI: 10.1038/s41392-023-01673-4

    1 Insight on

    • Not Reported

    • Moderate evidence
    • Highly Cited

  • Human milk oligosaccharide composition following supplementation with folic acid vs (6S)-5-methyltetrahydrofolic acid during pregnancy and mediation by human milk folate forms.

    • 2023-12-06
    • RCT · n = 60
    • European journal of clinical nutrition 78(4)
    • • Kelsey M Cochrane
      • Jeffrey N Bone
      • Crystal D Karakochuk
      • Lars Bode

    • PubMed: 38057412
    • DOI: 10.1038/s41430-023-01376-7

    1 Insight on

    • Reduced Total Human Milk Oligosaccharide Concentration

    • High evidence
    • Rigorous Journal

  • The probiotic Lacticaseibacillus rhamnosus HN001 influences the architecture and gene expression of small intestine tissue in a piglet model.

    • 2023-12-06
    • RCT
    • British Journal of Nutrition 131(8)
    • • Carlos A Montoya
      • Wayne Young
      • Leigh Ryan
      • K. Dunstan
      • Jason Peters
      • Hilary Dewhurst
      • J. Dekker
      • Neill Haggarty
      • R. Dilger
      • Nicole C. Roy

    • PubMed: 38053344
    • DOI: 10.1017/S0007114523002830

    3 Insights on

    • Improved Immune Response
    • Improved Small Intestinal Tissue Maturation
    • Elevated Blood Cytokine Levels

    • High evidence
• December 7

  • Safety and tolerability of topiramate and N-acetyl cysteine combination in individuals with alcohol use disorder: a 12 week, randomized, double-blind, pilot study.

    • 2023-12-07
    • RCT
    • Alcohol and alcoholism (Oxford, Oxfordshire) 59(2)
    • • Nassima A-D Tiouririne
      • Tevfik Kalelioglu
      • Chamindi Seneviratne
      • Xin-Qun Wang

    • PubMed: 38069498
    • DOI: 10.1093/alcalc/agad082

    6 Insights on

    • Reduced Heavy Drinking Day
    • Increased Days Abstinent
    • Reduced Automaticity of Drinking
    • Reduced Interference Due to Drinking
    • Reduced Drinking Obsessions
    • Reduced Alcohol Consumption

    • High evidence

  • Effect of Continuous Ingestion of Bifidobacteria and Inulin on Reducing Body Fat: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Study

    • 2023-12-07
    • RCT
    • Nutrients 15(24)
    • • Yuhei Baba
      • Yasuo Saito
      • Mei Kadowaki
      • Naoki Azuma
      • Daisuke Tsuge

    • PubMed: 38140284
    • DOI: 10.3390/nu15245025

    6 Insights on

    • Reduced Body Mass Index
    • Reduced Visceral Fat
    • Improved Bowel Movement Frequency
    • Increased Bifidobacteria Levels
    • Improved Intestinal Health
    • Improved Lipid Levels

    • High evidence
• December 8

  • Unravelling the Gastroprotective Potential of Kefir: Exploring Antioxidant Effects in Preventing Gastric Ulcers.

    • 2023-12-08
    • n = 35
    • Cells 12(24)
    • • Larissa Zambom Côco
      • Rafaela Aires
      • Glaucimeire Rocha Carvalho
      • Eduarda de Souza Belisário
      • Michelle Khai Khun Yap
      • Fernanda Gobbi Amorim
      • Javier Conde-Aranda
      • Breno Valentim Nogueira
      • Elisardo Corral Vasquez
      • Thiago de Melo Costa Pereira
      • Bianca Prandi Campagnaro

    • PubMed: 38132119
    • DOI: 10.3390/cells12242799

    7 Insights on

    • Reduced Inflammation
    • Reduced Oxidative Stress
    • Reduced Cell Apoptosis
    • Reduced Gastric Ulcer Area
    • Reduced Gastric Tissue Damage
    • Reduced Ulcer Formation
    • Increased Nitric Oxide Bioavailability

    • Low evidence
    • Animal Study
• December 9

  • Exploring the Impact of Hydrolyzed Collagen Oral Supplementation on Skin Rejuvenation: A Systematic Review and Meta-Analysis.

    • 2023-12-09
    • Review · n = 967
    • Cureus 15(12)
    • • Dian Andriani Ratna Dewi
      • Abraham Arimuko
      • Lilik Norawati
      • Satya W Yenny
      • Nenden L Setiasih
      • Angki Perdiyana
      • Nabila Arkania
      • Farrasila Nadhira
      • Ni Wiliantari

    • PubMed: 38192916
    • DOI: 10.7759/cureus.50231

    2 Insights on

    • Improved Skin Hydration
    • Improved Skin Elasticity

    • High evidence
• December 11

  • Folate-producing bifidobacteria: metabolism, genetics, and relevance.

    • 2023-12-11
    • Review
    • Microbiome research reports 3(1)
    • • Maria Rosaria D'Aimmo
      • Maria Satti
      • Donatella Scarafile
      • Monica Modesto
      • Stefano Pascarelli
      • Simone Andrea Biagini
      • Donata Luiselli
      • Paola Mattarelli
      • Thomas Andlid

    • PubMed: 38455078
    • DOI: 10.20517/mrr.2023.59

    1 Insight on

    • Increased Folate Production

    • Low evidence
• December 12

  • Efficacy and Safety of Bifidobacterium longum Supplementation in Infants: A Meta-Analysis of Randomized Controlled Trials

    • 2023-12-12
    • Meta-Analysis
    • Foods 12(24)
    • • Huangda Guo
      • Meng Fan
      • Tianjiao Hou
      • Yixin Li
      • Siyue Wang
      • Xueheng Wang
      • Hexiang Peng
      • Mengying Wang
      • Tao Wu
      • Yumei Zhang

    • PubMed: 38137255
    • DOI: 10.3390/foods12244451

    6 Insights on

    • Increased Body Weight
    • Reduced Risk of Necrotizing Enterocolitis
    • Occurrence of Adverse Events
    • Increased Occurrence of Serious Adverse Events
    • Adverse Events
    • Reduced Serious Adverse Events

    • High evidence
• December 13

  • Microbiota Composition and Probiotics Supplementations on Sleep Quality-A Systematic Review and Meta-Analysis.

    • 2023-12-13
    • Review
    • Clocks & sleep 5(4)
    • • Daniele Santi
      • Valentina Debbi
      • Francesco Costantino
      • Giorgia Spaggiari
      • Manuela Simoni
      • Carla Greco
      • Livio Casarini

    • PubMed: 38131749
    • DOI: 10.3390/clockssleep5040050

    1 Insight on

    • Improved Sleep Quality

    • Low evidence

  • Bifidobacterium animalis subsp. lactis BPL1™ and Its Lipoteichoic Acid Modulate Longevity and Improve Age/Stress-Related Behaviors in Caenorhabditis elegans.

    • 2023-12-13
    • Antioxidants (Basel, Switzerland) 12(12)
    • • Ferran Balaguer
      • Marta Barrena
      • María Enrique
      • Miren Maicas
      • Beatriz Álvarez
      • Marta Tortajada
      • Empar Chenoll
      • Daniel Ramón
      • Patricia Martorell

    • PubMed: 38136226
    • DOI: 10.3390/antiox12122107

    7 Insights on

    • Improved Cognitive Function
    • Improved Oxidative Stress Resistance
    • Increased Longevity
    • Improved Resistance to Infections
    • Improved Gut Barrier Function
    • Improved Stress-Related Behavior
    • Reduced Proteotoxicity

    • Low evidence
• December 14

  • Gut-Antimicrobial Peptides: Synergistic Co-Evolution with Antibiotics to Combat Multi-Antibiotic Resistance.

    • 2023-12-14
    • Review
    • Antibiotics (Basel, Switzerland) 12(12)
    • • Piyush Baindara
      • Santi M Mandal

    • PubMed: 38136766
    • DOI: 10.3390/antibiotics12121732

    2 Insights on

    • Reduced Pathogen Colonization
    • Reduced Risk of Infection

    • Low evidence

  • Safety, efficacy, and impact on gut microbial ecology of a Bifidobacterium longum subspecies infantis LMG11588 supplementation in healthy term infants: a randomized, double-blind, controlled trial in the Philippines

    • 2023-12-14
    • RCT
    • Frontiers in Nutrition 10
    • • Maria Rosario Z. Capeding
      • Loudhie Cyd M. Phee
      • Chang Ming
      • Mario Noti
      • Karine Vidal
      • Gilles Le Carrou
      • A. Frézal
      • J. M. Moll
      • Josef K Vogt
      • P. Myers
      • Bjørn Henrik Nielsen
      • Claire L. Boulangé
      • T. Samuel
      • Bernard Berger
      • Colin Ivano Cercamondi

    • PubMed: 38162520
    • DOI: 10.3389/fnut.2023.1319873

    5 Insights on

    • Improved Stool Consistency
    • Reduced Pro-Inflammatory Cytokines
    • Increased Acetic Acid Levels in Feces
    • Normal Infant Growth
    • Reduced Regurgitation Episodes

    • High evidence
• December 18

  • Combined Rehabilitation with Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol, and Cholecalciferolin Discogenic Sciatica in Young People: A Randomized Clinical Trial.

    • 2023-12-18
    • RCT · n = 128
    • Medicina (Kaunas, Lithuania) 59(12)
    • • Dalila Scaturro
      • Fabio Vitagliani
      • Sofia Tomasello
      • Cristiano Sconza
      • Stefano Respizzi
      • Giulia Letizia Mauro

    • PubMed: 38138300
    • DOI: 10.3390/medicina59122197

    2 Insights on

    • Reduced Pain
    • Reduced Disability

    • High evidence
    • Large Human Trial

  • Lactobacillus amylovorus KU4 induces adipose browning in obese mice by regulating PP4C.

    • 2023-12-18
    • The Journal of endocrinology 260(3)
    • • Garam Yang
      • Eunjeong Hong
      • Sejong Oh
      • Eungseok Kim

    • PubMed: 38109258
    • DOI: 10.1530/joe-23-0185

    2 Insights on

    • Increased Adipose Browning
    • Reduced PP4C Expression in Adipose Tissue

    • Low evidence
    • Animal Study
• December 19

  • Effects of niacin on apo A1 and B levels: a systematic review and meta-analysis of randomised controlled trials.

    • 2023-12-19
    • Meta-Analysis
    • The British journal of nutrition 131(7)
    • • Somayeh Saboori
      • Esmaeil Yousefi Rad
      • Jonathan Tammam
      • Pariyarath Sangeetha Thondre
      • Shelly Coe

    • PubMed: 38112076
    • DOI: 10.1017/s000711452300288x

    2 Insights on

    • Reduced Low-Density Lipoprotein Level
    • Increased Apolipoprotein A1 Level

    • High evidence
• December 21

  • Probiotics Bifidobacterium lactis M8 and Lactobacillus rhamnosus M9 prevent high blood pressure via modulating the gut microbiota composition and host metabolic products.

    • 2023-12-21
    • mSystems 8(6)
    • • Yong Zhang
      • Tingting Zheng
      • Da Ma
      • Peng Shi
      • Heping Zhang
      • Jun Li
      • Zhihong Sun

    • PubMed: 37855616
    • DOI: 10.1128/msystems.00331-23

    1 Insight on

    • Reduced Blood Pressure

    • Low evidence

  • Manipulating the growth environment through co-culture to enhance stress tolerance and viability of probiotic strains in the gastrointestinal tract.

    • 2023-12-21
    • Clinical Trial
    • Applied and environmental microbiology 89(12)
    • • Kosuke Oana
      • Kensuke Shimizu
      • Toshihiko Takada
      • Hiroshi Makino
      • Mikiko Yamazaki
      • Miyuki Katto
      • Minoru Ando
      • Takashi Kurakawa
      • Kenji Oishi

    • PubMed: 38019024
    • DOI: 10.1128/aem.01502-23

    1 Insight on

    • Improved Stress Tolerance

    • High evidence
    • Rigorous Journal

  • Enhancement of Immune Functions by Limosilactobacillus reuteri KBL346: In Vitro and In Vivo Studies.

    • 2023-12-21
    • International journal of molecular sciences 25(1)
    • • Chanseop Park
      • Seon Yeong Ji
      • Hyun Hwangbo
      • Seung-Yeon Shin
      • Min Yeong Kim
      • Kiuk Lee
      • Da Hye Kim
      • Bo-Ram Cho
      • Hyesook Lee
      • Yung Hyun Choi
      • Hyun Ju You

    • PubMed: 38203313
    • DOI: 10.3390/ijms25010141

    3 Insights on

    • Improved Immune Function
    • Improved Innate Immune Response
    • Reduced Immunosuppression-Related Spleen Injury

    • Low evidence
    • Rigorous Journal

  • The Role of Oral Probiotics in Alleviating Inflammation, Symptom Relief, and Postoperative Recurrence and Their Side Effects in Adults With Crohn's Disease: A Systematic Review.

    • 2023-12-21
    • Review · n = 2,023
    • Cureus 15(12)
    • • Devendar Banoth
      • Muhammad Hassaan Wali
      • Khava Bekova
      • Noor Abdulla
      • Simhachalam Gurugubelli
      • Yi Mon Lin
      • Safeera Khan

    • PubMed: 38259373
    • DOI: 10.7759/cureus.50901

    5 Insights on

    • Improved Quality of Life
    • Reduced Diarrhea Rate
    • Reduced Disease Severity
    • Reduced Inflammation
    • Improved Cognitive Reactivity to Sad Mood

    • High evidence
• December 26

  • Biosynthesis of Gamma-Aminobutyric Acid (GABA) by Lactiplantibacillus plantarum in Fermented Food Production.

    • 2023-12-26
    • Review
    • Current issues in molecular biology 46(1)
    • • Massimo Iorizzo
      • Gianluca Paventi
      • Catello Di Martino

    • PubMed: 38248317
    • DOI: 10.3390/cimb46010015

    2 Insights on

    • Improved Probiotic Functionality for Functional Foods Development
    • Increased GABA Production

    • Low evidence
• December 28

  • Evaluation of Safety and Probiotic Traits from a Comprehensive Genome-Based In Silico Analysis of Ligilactobacillus salivarius P1CEA3, Isolated from Pigs and Producer of Nisin S.

    • 2023-12-28
    • Foods (Basel, Switzerland) 13(1)
    • • Ester Sevillano
      • Irene Lafuente
      • Nuria Peña
      • Luis M Cintas
      • Estefanía Muñoz-Atienza
      • Pablo E Hernández
      • Juan Borrero

    • PubMed: 38201135
    • DOI: 10.3390/foods13010107

    3 Insights on

    • Improved Gut Health
    • Improved Probiotic Safety
    • Reduced Pathogenic Bacterial Activity

    • Low evidence
• December 29

  • Effect of Bacteriocins on the Intestinal Microbiota.

    • 2023-12-29
    • Review
    • The Eurasian journal of medicine 55(1)
    • • Selin Doğan
      • Taha Yasin Koç
      • Mehmet Karadayı

    • PubMed: 39128034
    • DOI: 10.5152/eurasianjmed.2023.23393

    3 Insights on

    • Improved Intestinal Microbiota
    • Regulated Intestinal Microbiota
    • Reduced Enteropathogen Colonization

    • Low evidence
• December 30

  • The dietary supplements effect on metabolic markers in non-pharmacologically managed gestational diabetes mellitus patients: a systematic review and meta-analysis and meta-regression of randomized controlled trials.

    • 2023-12-30
    • Meta-Analysis
    • Journal of diabetes and metabolic disorders 23(1)
    • • Sumanta Saha
      • Sujata Saha
      • Mohan Gayen

    • PubMed: 38932907
    • DOI: 10.1007/s40200-023-01369-0

    8 Insights on

    • Improved Insulin Sensitivity
    • Improved LDL Cholesterol
    • Improved Triglyceride Levels
    • Improved Total Cholesterol Levels
    • Reduced Plasma Glucose Levels
    • Improved Blood Lipid Profile
    • Improved VLDL Cholesterol
    • Reduced Beta Cell Function

    • High evidence
• December 31

  • Potential of γ-Aminobutyric Acid-Producing Leuconostoc mesenteroides Strains Isolated from Kimchi as a Starter for High-γ-Aminobutyric Acid Kimchi Fermentation.

    • 2023-12-31
    • Preventive nutrition and food science 28(4)
    • • Jihyun Ahn
      • Jae-Yong Park

    • PubMed: 38188089
    • DOI: 10.3746/pnf.2023.28.4.492

    2 Insights on

    • Increased GABA Production
    • Reduced Undesirable Fermentation Microbes

    • Low evidence
• Undated – 8 supplement studies

  • The efficacy and safety of oral microecological agents as add-on therapy for atopic dermatitis: A systematic review and meta-analysis of randomized clinical trials.

    • 2023-12
    • Review · n = 1,230
    • Clinical and translational allergy 13(12)
    • • Peiwen Xue
      • Haiyan Qin
      • Di Qin
      • Huilin Liu
      • Juan Li
      • Rongjiang Jin
      • Xianjun Xiao

    • PubMed: 38146806
    • DOI: 10.1002/clt2.12318

    2 Insights on

    • Reduced Atopic Dermatitis Severity
    • No Change in Adverse Events

    • High evidence

  • Metagenomic analysis of soybean endosphere microbiome to reveal signatures of microbes for health and disease.

    • 2023-12
    • n = 240
    • Journal, genetic engineering & biotechnology 21(1)
    • • Usha Chouhan
      • Umesh Gamad
      • Jyoti Kant Choudhari

    • PubMed: 37584775
    • DOI: 10.1186/s43141-023-00535-4

    1 Insight on

    • No Human Health Outcome Reported

    • Moderate evidence

  • Probiotic Influences on Motor Skills: A Review.

    • 2023-12
    • Review
    • Current neuropharmacology 21(12)
    • • Robert Lalonde
      • Catherine Strazielle

    • PubMed: 37550907
    • DOI: 10.2174/1570159x21666230807150523

    1 Insight on

    • Improved Motor Function

    • Low evidence

  • The effect of vitamin K supplementation on cardiovascular risk factors: a systematic review and meta-analysis.

    • 2024
    • Meta-Analysis
    • Journal of nutritional science 13
    • • Qiu-Yan Zhao
      • Qiu Li
      • Minoo Hasan Rashedi
      • Mohammadhassan Sohouli
      • Pejman Rohani
      • Periyannan Velu

    • PubMed: 38282652
    • DOI: 10.1017/jns.2023.106

    1 Insight on

    • Improved Insulin Sensitivity

    • High evidence

  • Virgin coconut oil (VCO) supplementation relieves symptoms and inflammation among COVID-19 positive adults: a single-blind randomized trial.

    • 2024
    • RCT · n = 19
    • Journal of nutritional science 13
    • • Imelda Angeles-Agdeppa
      • Jacus S Nacis
      • Fabian M Dayrit
      • Keith V Tanda

    • PubMed: 38282651
    • DOI: 10.1017/jns.2023.118

    2 Insights on

    • Reduced C-Reactive Protein Levels
    • Reduced COVID-19 Symptom Duration

    • High evidence

  • Multi-pharmacological treatment for young subfertile males with chronic prostatitis/chronic pelvic pain syndrome.

    • 2024
    • RCT · n = 50
    • Investigative and clinical urology 65(6)
    • • Dong Hyeon Lee
      • Young Dong Yu

    • PubMed: 39505516
    • DOI: 10.4111/icu.20240191

    2 Insights on

    • Improved Sperm Morphology
    • Improved Total Sperm Motility

    • High evidence

  • Sodium bicarbonate and beta-alanine supplementation: Is combining both better than either alone? A systematic review and meta-analysis.

    • 2024
    • Review · n = 243
    • Biology of sport 41(3)
    • • Terence Curran-Bowen
      • André Guedes da Silva
      • Gabriel Barreto
      • John Buckley
      • Bryan Saunders

    • PubMed: 38952910
    • DOI: 10.5114/biolsport.2024.132997

    1 Insight on

    • Improved Exercise Performance

    • High evidence

  • Association of Herbal Tea and Follicle-Stimulating Hormone, Anthropometric Parameters, and Fasting Blood Glucose Levels Among Polycystic Ovarian Syndrome Women: A Systematic Review and Meta-Analysis of Clinical Trials.

    • 2024
    • Review
    • Clinical nutrition research 13(3)
    • • Elahe Abbasi
      • Zahra Hajhashemy
      • Gholamreza Askari
      • Parvane Saneei

    • PubMed: 39165287
    • DOI: 10.7762/cnr.2024.13.3.201

    2 Insights on

    • Reduced Body Mass Index
    • Reduced Fasting Blood Glucose Levels

    • Low evidence