June 2019 Supplement Research Papers

• June 1

  • Analysis of Health Benefits Conferred by Lactobacillus Species from Kefir

    • 2019-06-01
    • Nutrients 11(6)
    • • Conor Slattery
      • P. Cotter
      • Paul W. O’Toole

    • PubMed: 31159409
    • DOI: 10.3390/nu11061252

    9 Insights on

    • Enhanced Antimicrobial Resistance
    • Suppressed Tumor Growth
    • Reduced Blood Glucose Levels
    • Improved Cholesterol Metabolism
    • Enhanced Antioxidant Defense
    • Reduced Th2 Reactions
    • Improved Insulin Sensitivity
    • Improved Anti-Oxidative Effects
    • Improved Immunomodulation

    • High evidence
    • Highly Cited

  • Phytotherapy as a Complementary Medicine for Multiple Sclerosis.

    • 2019-06-01
    • Review
    • Turkish journal of pharmaceutical sciences 16(2)
    • • Zahra Rabiei

    • PubMed: 32454721
    • DOI: 10.4274/tjps.galenos.2018.90522

    4 Insights on

    • Improved Urinary Tract Complication
    • Reduced Neuropathic Pain
    • Improved Spasticity
    • Improved Muscle Spasm

    • Low evidence

  • [Influence of different timing of Saccharomyces boulardii combined with bismuth quadruple therapy for Helicobacter pylori eradication].

    • 2019-06-01
    • RCT · n = 300
    • Zhonghua yi xue za zhi 99(22)
    • • C X He
      • F T Kong
      • F Liang
      • K X Wang
      • H Li
      • Y L Liu
      • W Zhao
      • P P Zhou
      • F L Kong

    • PubMed: 31216821
    • DOI: 10.3760/cma.j.issn.0376-2491.2019.22.010

    1 Insight on

    • Improved H Pylori Eradication Rates

    • High evidence
    • Large Human Trial
• June 4

  • Skin Transcriptome of Middle-Aged Women Supplemented With Natural Herbo-mineral Shilajit Shows Induction of Microvascular and Extracellular Matrix Mechanisms.

    • 2019-06-04
    • RCT
    • Journal of the American College of Nutrition 38(6)
    • • Amitava Das
      • Mohamed S El Masry
      • Surya C Gnyawali
      • Surya C Gnyawali
      • Subhadip Ghatak
      • Kanhaiya Singh
      • Richard Stewart
      • Madeline Lewis
      • Abhijoy Saha
      • Gayle Gordillo
      • Savita Khanna

    • PubMed: 31161927
    • DOI: 10.1080/07315724.2018.1564088

    3 Insights on

    • Improved Endothelial Cell Migration
    • Improved Blood Vessel Growth
    • Improved Skin Perfusion

    • High evidence
    • Rigorous Journal

  • Staphylococcus succinus 14BME20 Prevents Allergic Airway Inflammation by Induction of Regulatory T Cells via Interleukin-10.

    • 2019-06-04
    • Frontiers in immunology 10
    • • Jisun Song
      • Hui Xuan Lim
      • Arim Lee
      • Soojung Kim
      • Jong-Hoon Lee
      • Tae Sung Kim

    • PubMed: 31231389
    • DOI: 10.3389/fimmu.2019.01269

    2 Insights on

    • Reduced Allergic Lung Inflammation
    • Increased Regulatory T Cell Response

    • Low evidence
    • Animal Study
• June 5

  • Prophylactic effects of probiotic Bifidobacterium spp. in the resolution of inflammation in arthritic rats

    • 2019-06-05
    • Clinical Trial
    • Applied Microbiology and Biotechnology 103(15)
    • • S. Achi
      • R. Talahalli
      • P. Halami

    • PubMed: 31168650
    • DOI: 10.1007/s00253-019-09864-2

    5 Insights on

    • Reduced Inflammation Markers
    • Improved Bone Mineral Content
    • Modulated Eicosanoid Levels
    • Reduced Paw Volume
    • Regulated Cytokine Levels

    • Low evidence
    • Animal Study
• June 7

  • Lactobacillus fermentum CECT5716: a novel alternative for the prevention of vascular disorders in a mouse model of systemic lupus erythematosus

    • 2019-06-07
    • RCT
    • The FASEB Journal 33(9)
    • • M. Toral
      • Iñaki Robles‐Vera
      • M. Romero
      • N. Visitación
      • M. Sánchez
      • F. O’Valle
      • A. Rodríguez‐Nogales
      • J. Gálvez
      • J. Duarte
      • R. Jiménez

    • PubMed: 31173526
    • DOI: 10.1096/fj.201900545RR

    10 Insights on

    • Increased Gut Bifidobacterium Count
    • Improved Vascular Endothelial Function
    • Reduced Splenomegaly
    • Reduced Lupus Disease Activity
    • Reduced Cardiac Hypertrophy
    • Reduced Pro-Inflammatory Cytokines
    • Reduced Blood Pressure
    • Reduced Plasma LPS Levels
    • Reduced Renal Hypertrophy
    • Reduced Elevated Immune Cells in Mesenteric Lymph Nodes

    • Low evidence
    • Animal Study
• June 13

  • Effect of heat-killed Streptococcus thermophilus on type 2 diabetes rats

    • 2019-06-13
    • Clinical Trial
    • PeerJ 7
    • • Xiangyang Gao
      • Fei Wang
      • Peng Zhao
      • Rong Zhang
      • Q. Zeng

    • PubMed: 31223540
    • DOI: 10.7717/peerj.7117

    4 Insights on

    • Reduced Serum Glucose Levels
    • Reduced Inflammatory Markers
    • Improved Abundance of Beneficial Bacteria
    • Reduced Total Cholesterol Levels

    • Low evidence
    • Rigorous Journal
    • Animal Study
• June 14

  • Protective effects of a novel probiotic strain, Lactococcus lactis ML2018, in colitis: in vivo and in vitro evidence.

    • 2019-06-14
    • Food & Function 10(2)
    • • Mei-ling Liu
      • Xiuxia Zhang
      • Y. Hao
      • Jinhua Ding
      • Jing Shen
      • Ziyu Xue
      • W. Qi
      • Zhongyuan Li
      • Yajian Song
      • Tongcun Zhang
      • Nan Wang

    • PubMed: 30724927
    • DOI: 10.1039/c8fo02301h

    2 Insights on

    • Reduced Inflammatory Factor Production
    • Reduced Intestinal Inflammation

    • Low evidence

  • Differential Effects of Oral Boluses of Vitamin D2 vs Vitamin D3 on Vitamin D Metabolism: A Randomized Controlled Trial.

    • 2019-06-14
    • RCT · n = 52
    • The Journal of clinical endocrinology and metabolism 104(12)
    • • Adrian R Martineau
      • Kenneth E Thummel
      • Zhican Wang
      • David A Jolliffe
      • Barbara J Boucher
      • Simon J Griffin
      • Nita G Forouhi
      • Graham A Hitman

    • PubMed: 31199458
    • DOI: 10.1210/jc.2019-00207

    12 Insights on

    • Increased 24R,25-Dihydroxyvitamin D3 Level
    • Raised Total 25-Hydroxyvitamin D Concentration
    • Reduced Ratio of 24R,25-Dihydroxyvitamin D3 to 25-Hydroxyvitamin D3
    • Increased Vitamin D3 Ratio
    • Reduced Ratio of 25-Hydroxyvitamin D3 to Vitamin D3
    • Reduced Vitamin D Metabolite Ratio
    • Increased 1α,25-Dihydroxyvitamin D3 Level
    • Increased 24R,25-Dihydroxyvitamin D3 to 25-Hydroxyvitamin D3 Ratio
    • Reduced 1α,25-Dihydroxyvitamin D3 to 25-Hydroxyvitamin D3 Ratio
    • Increased 25-Hydroxyvitamin D3 to Vitamin D3 Ratio
    • Increased 4β,25-Dihydroxyvitamin D3 Level
    • Increased 25-Hydroxyvitamin D3 Level

    • High evidence
• June 15

  • Acetyl-L-carnitine for the treatment of diabetic peripheral neuropathy.

    • 2019-06-15
    • Meta-Analysis · n = 907
    • The Cochrane database of systematic reviews 2019(6)
    • • Luiz Csp Rolim
      • Edina Mk da Silva
      • Ronald Lg Flumignan
      • Marcio M Abreu
      • Sérgio A Dib

    • PubMed: 31201734
    • DOI: 10.1002/14651858.cd011265.pub2

    4 Insights on

    • Improved Vibration Perception
    • Reduced Functional Impairment
    • Reduced Pain
    • Reduced Neuropathy Disability Score

    • High evidence
• June 17

  • Biotransformation of Cranberry Proanthocyanidins to Probiotic Metabolites by Lactobacillus rhamnosus Enhances Their Anticancer Activity in HepG2 Cells In Vitro

    • 2019-06-17
    • Oxidative Medicine and Cellular Longevity 2019
    • • H. Rupasinghe
      • Indu Parmar
      • Sandhya V. Neir

    • PubMed: 31316718
    • DOI: 10.1155/2019/4750795

    1 Insight on

    • Increased Anticancer Activity

    • Low evidence
    • Rigorous Journal
• June 18

  • Prophylactic Effects of Bifidobacterium adolescentis on Anxiety and Depression-Like Phenotypes After Chronic Stress: A Role of the Gut Microbiota-Inflammation Axis

    • 2019-06-18
    • Clinical Trial
    • Frontiers in Behavioral Neuroscience 13
    • • Ying Guo
      • Jianping Xie
      • Ke Deng
      • Xia Li
      • Yun Yuan
      • Qun Xuan
      • Jing Xie
      • Xiao-Ming He
      • Qian Wang
      • Juan-Juan Li
      • Huai-Rong Luo

    • PubMed: 31275120
    • DOI: 10.3389/fnbeh.2019.00126

    8 Insights on

    • Reduced Anxiety
    • Reduced Anxiety Levels
    • Improved Gut Microbiome Composition
    • Balanced Gut Microbiota
    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Depression Symptoms
    • Reduced Inflammation Levels
    • Enhanced Brain-Derived Neurotrophic Factor Levels

    • Low evidence
    • Animal Study

  • Effect of Vitamin K2 on Postural Sway in Older People Who Fall: A Randomized Controlled Trial.

    • 2019-06-18
    • RCT · n = 95
    • Journal of the American Geriatrics Society 67(10)
    • • Miles D Witham
      • Rosemary J G Price
      • Margaret M Band
      • Michael S Hannah
      • Roberta L Fulton
      • Clare L Clarke
      • Peter T Donnan
      • Paul McNamee
      • Vera Cvoro
      • Roy L Soiza

    • PubMed: 31211416
    • DOI: 10.1111/jgs.16024

    7 Insights on

    • Reduced Fall Rate
    • Improved Short Physical Performance Battery
    • Reduced Anteroposterior Sway
    • Improved Quality of Life
    • Reduced Health and Social Care Costs
    • Improved Berg Balance Scale
    • Improved Timed Up and Go Test

    • High evidence
• June 19

  • A systematic review of the efficacy of alternative medicine in the treatment of nausea and vomiting of pregnancy.

    • 2019-06-19
    • Systematic Review
    • Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 40(1)
    • • Fahimeh Khorasani
      • Hossein Aryan
      • Abousaleh Sobhi
      • Reihaneh Aryan
      • Arefeh Abavi-Sani
      • Masumeh Ghazanfarpour
      • Masumeh Saeidi
      • Fatemeh Rajab Dizavandi

    • PubMed: 31215276
    • DOI: 10.1080/01443615.2019.1587392

    3 Insights on

    • Reduced Nausea
    • Reduced Vomiting
    • Reduced Nausea and Vomiting

    • High evidence
• June 21

  • Substituting brown rice for white rice on diabetes risk factors in India: a randomised controlled trial.

    • 2019-06-21
    • RCT · n = 166
    • The British journal of nutrition 121(12)
    • • V S Malik
      • V Sudha
      • N M Wedick
      • M RamyaBai
      • P Vijayalakshmi
      • N Lakshmipriya
      • R Gayathri
      • A Kokila
      • C Jones
      • B Hong
      • R Li
      • K Krishnaswamy
      • R M Anjana
      • D Spiegelman
      • W C Willett
      • F B Hu
      • V Mohan

    • PubMed: 31006420
    • DOI: 10.1017/s000711451900076x

    9 Insights on

    • Reduced Insulin Levels
    • Reduced Blood Cholesterol
    • Reduced HOMA-IR
    • Reduced LDL Cholesterol
    • Reduced C-Reactive Protein Levels
    • Reduced Triglyceride Levels
    • Increased HDL Cholesterol Levels
    • Reduced Hemoglobin A1c
    • Reduced Fasting Blood Glucose Levels

    • High evidence
    • Large Human Trial

  • Laxative effects of triple fermented barley extracts (FBe) on loperamide (LP)-induced constipation in rats.

    • 2019-06-21
    • n = 48
    • BMC complementary and alternative medicine 19(1)
    • • Jong-Min Lim
      • Young Dae Kim
      • Chang-Hyun Song
      • Su-Jin Park
      • Dong-Chan Park
      • Hyung-Rae Cho
      • Go-Woon Jung
      • Khawaja Muhammad Imran Bashir
      • Sae Kwang Ku
      • Jae-Suk Choi

    • PubMed: 31226979
    • DOI: 10.1186/s12906-019-2557-x

    1 Insight on

    • Improved Constipation

    • Low evidence

  • Effects of Bifidobacterium infantis on cytokine-induced neutrophil chemoattractant and insulin-like growth factor-1 in the ileum of rats with endotoxin injury

    • 2019-06-21
    • RCT
    • World Journal of Gastroenterology 25(23)
    • • Wei Wang
      • Mei Sun
      • Yubo Zheng
      • Liuying Sun
      • Shuzhang Qu

    • PubMed: 31249450
    • DOI: 10.3748/wjg.v25.i23.2924

    1 Insight on

    • Improved Intestinal Barrier Function

    • Low evidence
    • Rigorous Journal
    • Animal Study
• June 24

  • Effects of dietary Clostridium butyricum addition to sows in late gestation and lactation on reproductive performance and intestinal microbiota1.

    • 2019-06-24
    • RCT
    • Journal of Animal Science 97(8)
    • • Meng Cao
      • Yan Li
      • Qiujie Wu
      • Pan Zhang
      • Wentao Li
      • Zhengyu Mao
      • Dongmei Wu
      • Xuemei Jiang
      • Y. Zhuo
      • Z. Fang
      • L. Che
      • Shengyu Xu
      • B. Feng
      • Jian Li
      • Yan Lin
      • De Wu

    • PubMed: 31233597
    • DOI: 10.1093/jas/skz186

    6 Insights on

    • Reduced Farrowing Duration
    • Improved Antioxidant Capacity
    • Reduced Serum Endotoxin Level
    • Reduced Serum MDA Concentrations
    • Reduced Serum Cortisol Levels
    • Increased Litter Weight at Weaning

    • High evidence
    • Rigorous Journal
• June 26

  • Lactobacillus plantarum TW1-1 Alleviates Diethylhexylphthalate-Induced Testicular Damage in Mice by Modulating Gut Microbiota and Decreasing Inflammation

    • 2019-06-26
    • Clinical Trial
    • Frontiers in Cellular and Infection Microbiology 9
    • • Xiao-zhu Tian
      • Zhengsheng Yu
      • P. Feng
      • Ze Ye
      • Rong Li
      • Juyuan Liu
      • Jun-ping Hu
      • Apurva Kakade
      • Pu Liu
      • Xiangkai Li

    • PubMed: 31297340
    • DOI: 10.3389/fcimb.2019.00221

    7 Insights on

    • Reduced Intestinal Hyperpermeability
    • Reduced Inflammatory Response
    • Reduced Hepatic Oxidative Stress
    • Improved Semen Quality
    • Improved Gut Microbiota Diversity
    • Increased Serum Testosterone Levels
    • Reduced Gonadal Development Defects

    • Low evidence
    • Animal Study

  • L-DOPA improves extinction memory retrieval after successful fear extinction.

    • 2019-06-26
    • RCT · n = 79
    • Psychopharmacology 236(12)
    • • A M V Gerlicher
      • O Tüscher
      • R Kalisch

    • PubMed: 31243481
    • DOI: 10.1007/s00213-019-05301-4

    1 Insight on

    • Reduced Conditioned Fear Response

    • High evidence

  • P40 and P75 Are Singular Functional Muramidases Present in the Lactobacillus casei /paracasei/rhamnosus Taxon

    • 2019-06-26
    • Frontiers in Microbiology 10
    • • Christine Bäuerl
      • G. Abitayeva
      • Sebastián Sosa-Carrillo
      • Ana Mencher-Beltrán
      • Noemí Navarro-Lleó
      • J. M. Coll-Marqués
      • Manuel Zúñiga-Cabrera
      • S. Shaikhin
      • G. Pérez-Martínez

    • PubMed: 31297099
    • DOI: 10.3389/fmicb.2019.01420

    1 Insight on

    • Increased Antiapoptotic Activity

    • Low evidence
• June 27

  • A New Isolate of Pediococcus pentosaceus (SL001) With Antibacterial Activity Against Fish Pathogens and Potency in Facilitating the Immunity and Growth Performance of Grass Carps

    • 2019-06-27
    • Clinical Trial
    • Frontiers in Microbiology 10
    • • L. Gong
      • Haocheng He
      • Dongjie Li
      • Lina Cao
      • T. Khan
      • Yanping Li
      • Lifei Pan
      • Liang Yan
      • Xuezhi Ding
      • Yunjun Sun
      • Youming Zhang
      • Ganfeng Yi
      • Shengbiao Hu
      • L. Xia

    • PubMed: 31316478
    • DOI: 10.3389/fmicb.2019.01384

    10 Insights on

    • Improved Survival Rate Against Fish Pathogens
    • Increased Survival Rate Against Fish Pathogens
    • Improved Immune Function
    • Enhanced Immune Response
    • Improved Intestinal Function
    • Improved Gut Health
    • Improved Immune Response
    • Increased Survival Against Pathogens
    • Modulated Gut Microbiota
    • Enhanced Growth Rate

    • Low evidence
    • Animal Study

  • Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects-results from the POUDER pilot study.

    • 2019-06-27
    • Clinical Trial · n = 40
    • Investigational new drugs 38(3)
    • • Vladimir J Lozanovski
      • Georgios Polychronidis
      • Wolfgang Gross
      • Negin Gharabaghi
      • Arianeb Mehrabi
      • Thilo Hackert
      • Peter Schemmer
      • Ingrid Herr

    • PubMed: 31250356
    • DOI: 10.1007/s10637-019-00826-z

    4 Insights on

    • Increased Nausea
    • Increased Emesis
    • Improved Overall Survival
    • Increased Digestive Problem

    • High evidence

  • Associations of cervicovaginal lactobacilli with high-risk HPV infection, cervical intraepithelial neoplasia, and cancer: a systematic review and meta-analysis.

    • 2019-06-27
    • Meta-Analysis
    • The Journal of Infectious Diseases 220(8)
    • • Huiyan Wang
      • Yan Ma
      • Ruonan Li
      • Xixi Chen
      • Lijuan Wan
      • Weidong Zhao

    • PubMed: 31242505
    • DOI: 10.1093/infdis/jiz325

    2 Insights on

    • Reduced Detection of High-Risk HPV Infection
    • Reduced Detection of Cervical Intraepithelial Neoplasia

    • High evidence
    • Rigorous Journal
• June 30

  • Oral Administration of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 with Cinnamomi Ramulus Extract Reduces Diet-Induced Obesity and Modulates Gut Microbiota

    • 2019-06-30
    • RCT · n = 5
    • Preventive Nutrition and Food Science 24(2)
    • • Woonhee Jeung
      • Woo Nam
      • Hyeonji Kim
      • Joo Yun Kim
      • Bora Nam
      • S. Jang
      • Jung-Lyoul Lee
      • J. Sim
      • Soo-Dong Park

    • PubMed: 31328117
    • DOI: 10.3746/pnf.2019.24.2.136

    4 Insights on

    • Reduced Body Weight
    • Increased Adiponectin Levels
    • Reduced Blood Leptin Levels
    • Improved Gut Microbiota Diversity

    • Low evidence
    • Rigorous Journal
    • Animal Study
• Undated – 7 supplement studies

  • Lactobacillus plantarum DR7 improved upper respiratory tract infections via enhancing immune and inflammatory parameters: A randomized, double-blind, placebo-controlled study.

    • 2019-06
    • RCT · n = 109
    • Journal of Dairy Science 102(6)
    • • H. Chong
      • N. A. A. Yusoff
      • Y. Hor
      • L. Lew
      • M. Jaafar
      • S. Choi
      • M. Yusoff
      • N. Wahid
      • M. F. I. L. Abdullah
      • Norzila Zakaria
      • Kee-Leong Ong
      • Yong-Ha Park
      • M. Liong

    • PubMed: 30954261
    • DOI: 10.3168/jds.2018-16103

    5 Insights on

    • Reduced Proinflammatory Cytokines in Middle-aged Adults
    • Reduced Duration of Nasal Symptoms
    • Reduced Pro-Inflammatory Cytokines
    • Increased Anti-Inflammatory Cytokine Levels
    • Reduced Frequency of Upper Respiratory Tract Infections

    • High evidence
    • Highly Cited
    • Rigorous Journal

  • Evaluation of adherence and anti-infective properties of probiotic Lactobacillus fermentum strain 4-17 against Escherichia coli causing urinary tract infection in humans.

    • 2019-06
    • Microbial Pathogenesis 131
    • • F. Falah
      • A. Vasiee
      • B. A. Behbahani
      • F. T. Yazdi
      • S. Moradi
      • S. Mortazavi
      • S. Roshanak

    • PubMed: 30974159
    • DOI: 10.1016/j.micpath.2019.04.006

    6 Insights on

    • Improved Intestinal Cell Adhesion
    • Reduced Cellular Hydrophobicity
    • Reduced Pathogen Adhesion
    • Reduced Intestinal Cell Adhesion
    • Improved Cell Adhesion
    • Reduced Adhesion of Escherichia coli

    • Low evidence

  • Lactobacillus brevis DM9218 ameliorates fructose-induced hyperuricemia through inosine degradation and manipulation of intestinal dysbiosis.

    • 2019-06
    • Clinical Trial
    • Nutrition 62
    • • Haina Wang
      • L. Mei
      • Ying Deng
      • Yinhui Liu
      • Xiaoqing Wei
      • Man Liu
      • J. Zhou
      • Hong-Peng Ma
      • P. Zheng
      • Jieli Yuan
      • Ming Li

    • PubMed: 30852460
    • DOI: 10.1016/j.nut.2018.11.018

    5 Insights on

    • Improved Serum Uric Acid Levels
    • Reduced Hepatic Xanthine Oxidase Activity
    • Reduced Liver Damage
    • Improved Intestinal Barrier Function
    • Reduced Uric Acid Levels

    • Low evidence
    • Animal Study

  • Bacillus subtilis 29784 induces a shift in broiler gut microbiome toward butyrate-producing bacteria and improves intestinal histomorphology and animal performance.

    • 2019-06
    • RCT · n = 1,600
    • Poultry Science 98(6)
    • • Vincent Jacquier
      • Adam Nelson
      • M. Jlali
      • L. Rhayat
      • K. Brinch
      • E. Devillard

    • PubMed: 30668816
    • DOI: 10.3382/ps/pey602

    13 Insights on

    • Increased Gut Microvilli Length
    • Increased Butyrate-Producing Gut Bacteria
    • Increased Intestinal Microvilli Length
    • Improved Growth Performance
    • Increased Conjugated Linoleic Acid Levels
    • Enhanced Immune Function
    • Improved Gastrointestinal Health
    • Increased Butyrate Levels
    • Increased Anti-Inflammatory Levels
    • Increased Body Weight
    • Improved Intestinal Morphology
    • Increased Conjugated Linoleic Acid Production
    • Improved Body Weight

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Increasing salivary IgA and reducing Streptococcus mutans by probiotic Lactobacillus paracasei SD1: A double-blind, randomized, controlled study

    • 2019-06
    • RCT · n = 40
    • Journal of Dental Sciences 14(2)
    • • Nuntiya Pahumunto
      • B. Sophatha
      • S. Piwat
      • R. Teanpaisan

    • PubMed: 31210892
    • DOI: 10.1016/j.jds.2019.01.008

    6 Insights on

    • Increased Salivary sIgA Levels
    • Reduced Streptococcus Mutans Levels
    • Increased Levels of Lactobacillus Paracasei/Casei
    • Reduced Cariogenic Bacteria Levels
    • Increased Salivary IgA Levels
    • Reduced Salivary Levels of Mutans Streptococci

    • High evidence
    • Rigorous Journal

  • Lactobacillus reuteri DSM 17938 in the prevention of antibiotic-associated diarrhoea in children: a randomized clinical trial.

    • 2019-06
    • RCT · n = 250
    • Clinical Microbiology and Infection 25(6)
    • • M. Kołodziej
      • H. Szajewska

    • PubMed: 30149135
    • DOI: 10.1016/j.cmi.2018.08.017

    6 Insights on

    • Prevention of Antibiotic-Associated Diarrhea
    • Reduced Antibiotic-Associated Diarrhoea in Children
    • Reduced Antibiotic-Associated Diarrhea
    • Reduced Diarrhea Incidence
    • Reduced Incidence of Diarrhoea in Children
    • Reduced Diarrhea Rate

    • High evidence
    • Rigorous Journal

  • Effectiveness of the probiotic Streptococcus salivarius K12 for the treatment and/or prevention of sore throat: a systematic review.

    • 2019-06
    • Systematic Review
    • Clinical Microbiology and Infection 25(6)
    • • C. Wilcox
      • C. Wilcox
      • B. Stuart
      • Hannah Leaver
      • M. Lown
      • M. Willcox
      • Michael Moore
      • P. Little

    • PubMed: 30616011
    • DOI: 10.1016/j.cmi.2018.12.031

    9 Insights on

    • Reduced Acute Pharyngotonsillitis
    • Improved Effectiveness in Acute Pharyngotonsillitis Treatment
    • No Significant Benefit for Acute Pharyngotonsillitis
    • Reduced Exacerbation of Chronic Adenoiditis
    • Reduced Adenoiditis Exacerbation
    • Incidence of Streptococcal Pharyngitis
    • Reduced Incidence of Streptococcal Pharyngitis
    • Reduced Streptococcal Pharyngitis
    • No Significant Impact on Streptococcal Pharyngitis

    • High evidence
    • Rigorous Journal