August 2022 Supplement Research Papers

• August 2

  • Health Functions of Egg Protein.

    • 2022-08-02
    • Review
    • Foods (Basel, Switzerland) 11(15)
    • • Ryosuke Matsuoka
      • Michihiro Sugano

    • PubMed: 35954074
    • DOI: 10.3390/foods11152309

    4 Insights on

    • Reduced Visceral Fat
    • Increased Muscle Mass
    • Reduced Total Cholesterol
    • Enhanced Strength

    • Low evidence

  • The effect of flaxseed intake on appetite reduction: A systematic review of randomized clinical trials.

    • 2022-08-02
    • Systematic Review
    • Phytotherapy research : PTR 36(10)
    • • Mahtab Zarei
      • Shaghayegh Adeli
      • Shabnam Hosseini
      • Elnaz Daneshzad

    • PubMed: 35916016
    • DOI: 10.1002/ptr.7570

    5 Insights on

    • Reduced Appetite
    • Reduced Hunger
    • Increased Satiety
    • Reduced Prospective Consumption
    • Increased Fullness

    • High evidence
• August 3

  • Effects of Tribulus terrestris L. on Sport and Health Biomarkers in Physically Active Adult Males: A Systematic Review.

    • 2022-08-03
    • Systematic Review
    • International journal of environmental research and public health 19(15)
    • • Diego Fernández-Lázaro
      • Cesar I Fernandez-Lazaro
      • Jesús Seco-Calvo
      • Evelina Garrosa
      • David P Adams
      • Juan Mielgo-Ayuso

    • PubMed: 35954909
    • DOI: 10.3390/ijerph19159533

    4 Insights on

    • Improved Blood Lipid Profile
    • Reduced Inflammatory Biomarker Level
    • Improved Hematological Biomarker
    • No Change in Renal Biomarker Level

    • High evidence

  • Lactobacillus acidophilus LA85 ameliorates cyclophosphamide-induced immunosuppression by modulating Notch and TLR4/NF-κB signal pathways and remodeling the gut microbiota.

    • 2022-08-03
    • Clinical Trial
    • Food & Function 13(15)
    • • L. Xue
      • Zongqi Li
      • Jiabao Xue
      • Huiting Wang
      • Tao Wu
      • R. Liu
      • Wenjie Sui
      • M. Zhang

    • PubMed: 35793105
    • DOI: 10.1039/d1fo04331e

    8 Insights on

    • Improved Gut Microbiota Composition
    • Improved Immune Response
    • Improved Gut Microbiome Composition
    • Improved Intestinal Mucosal Repair
    • Enhanced Immunity
    • Modulated Gut Microbiota
    • Normalized Gut Microbiota
    • Improved Cyclophosphamide-Induced Immunosuppression

    • Low evidence
    • Animal Study

  • Use of Limosilactobacillus reuteri DSM 17938 in paediatric gastrointestinal disorders: an updated review.

    • 2022-08-03
    • Review
    • Beneficial Microbes 13(3)
    • • V. Dargenio
      • F. Cristofori
      • C. Dargenio
      • P. Giordano
      • F. Indrio
      • G. Celano
      • R. Francavilla

    • PubMed: 35212258
    • DOI: 10.3920/BM2021.0151

    19 Insights on

    • Reduced Antibiotic-Associated Diarrhea
    • Reduced Duration of Diarrhea
    • Reduced Hospitalization Duration
    • Reduced Abdominal Pain
    • Reduced Diarrhea Rate
    • Improved Gastrointestinal Transit
    • Improved Gut Microbiota Balance
    • Increased Pain Threshold
    • Reduced Hospitalization for Acute Gastroenteritis
    • Increased Helicobacter pylori Eradication Rate
    • Improved Gut Dysbiosis
    • Improved Intestinal Motility
    • Improved H Pylori Eradication Rates
    • Reduced Colic Symptoms
    • Improved Pain Threshold
    • Reduced Antibiotic-Associated Side Effects in Helicobacter pylori Infection
    • Improved Functional Constipation
    • Reduced Side Effects from Antibiotic Treatment
    • Reduced Regurgitation

    • Low evidence

  • Safety of Bifidobacterium breve, Bif195, employing a human exercise-induced intestinal permeability model: a randomised, double-blinded, placebo-controlled, parallel group trial.

    • 2022-08-03
    • RCT · n = 189
    • Beneficial Microbes 13(3)
    • • S. Engel
      • B. Mortensen
      • A. Wellejus
      • N. Vera-Jiménez
      • C. Struve
      • R. Brummer
      • A. Damholt
      • T. Woods
      • F. Shanahan

    • PubMed: 35866597
    • DOI: 10.3920/BM2021.0173

    4 Insights on

    • Improved Safety Profile
    • Increased Occurrence of Serious Adverse Events
    • Increased Intestinal Permeability Under Exercise-induced Stress
    • Baseline Intestinal Permeability

    • High evidence

  • Safety and tolerance of Lacticaseibacillus paracasei N1115 in caesarean-born young children: a randomised, placebo-controlled trial.

    • 2022-08-03
    • RCT · n = 101
    • Beneficial Microbes 13(3)
    • • Z. Ren
      • A. Zhao
      • J. Zhang
      • C. Yang
      • W. Zhong
      • S. Mao
      • S. Wang
      • Q. Yuan
      • P. Wang
      • Y. Zhang

    • PubMed: 35300564
    • DOI: 10.3920/BM2021.0132

    6 Insights on

    • Reduced Abdominal Pain Frequency
    • No Adverse Events Observed
    • Reduced Incidence of Constipation
    • Increased Stool Frequency
    • No Change in Anthropometric Parameters
    • No Change in Neurocognitive Development

    • High evidence
• August 4

  • Skin Dialogues in Atopic Dermatitis.

    • 2022-08-04
    • Review
    • Diagnostics (Basel, Switzerland) 12(8)
    • • Elena Porumb-Andrese
      • Claudia Florida Costea
      • Andrei Cucu
      • Gabriela Rusu-Zota
      • Daciana Elena Braisteanu
      • Vlad Porumb
      • Mihaela Monica Scutariu
      • Alexandra Maria Dorobanțu
      • Ramona Gabriela Ursu

    • PubMed: 36010238
    • DOI: 10.3390/diagnostics12081889

    2 Insights on

    • Improved Skin Barrier Function
    • Reduced Atopic Dermatitis Severity

    • Low evidence
• August 11

  • Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials.

    • 2022-08-11
    • Meta-Analysis · n = 425
    • Frontiers in public health 10
    • • Ming-Ling Ma
      • Zi-Jian Ma
      • Yi-Lang He
      • Hao Sun
      • Bin Yang
      • Bin-Jia Ruan
      • Wan-da Zhan
      • Shi-Xuan Li
      • Hui Dong
      • Yong-Xiang Wang

    • PubMed: 36033779
    • DOI: 10.3389/fpubh.2022.979649

    2 Insights on

    • Increased Bone Mineral Density
    • Reduced Fracture Incidence

    • High evidence

  • Lacticaseibacillus rhamnosus alleviates intestinal inflammation and promotes microbiota-mediated protection against Salmonella fatal infections

    • 2022-08-11
    • Clinical Trial
    • Frontiers in Immunology 13
    • • Xianqi Peng
      • Abdelaziz Ed-dra
      • Yan Song
      • Mohammed Elbediwi
      • Reshma B. Nambiar
      • Xiaoping Zhou
      • Min Yue

    • PubMed: 36032095
    • DOI: 10.3389/fimmu.2022.973224

    9 Insights on

    • Improved Gut Microbiota Diversity
    • Improved Intestinal Barrier Function
    • Reduced Diarrhea Incidence
    • Improved Intestinal Mucosal Immunity
    • Improved Average Daily Gain
    • Reduced Intestinal Inflammation
    • Improved Cell Survival Rates
    • Improved Intestinal Epithelial Cell Function
    • Improved Gut Immunity

    • Low evidence
    • Animal Study

  • Immunomodulatory Effects of Bifidobacterium spp. and Use of Bifidobacterium breve and Bifidobacterium longum on Acute Diarrhea in Children

    • 2022-08-11
    • Journal of Microbiology and Biotechnology 32(9)
    • • Y. Choi
      • S. Shin
      • H. Shin

    • PubMed: 36039384
    • DOI: 10.4014/jmb.2206.06023

    3 Insights on

    • Reduced Pro-inflammatory Cytokine Release
    • Reduced Diarrhea Symptoms
    • Enhanced Anti-inflammatory Response

    • Low evidence
• August 13

  • Evaluation of the recovery after heart surgery following preoperative supplementation with a combination of beta-hydroxy-beta-methylbutyrate, L-arginine, and L-glutamine: a double-blind randomized placebo-controlled clinical trial.

    • 2022-08-13
    • RCT · n = 70
    • Trials 23(1)
    • • Mona Norouzi
      • Azadeh Nadjarzadeh
      • Majid Maleki
      • Sayyed Saeid Khayyatzadeh
      • Saeid Hosseini
      • Mehdi Yaseri
      • Hamed Fattahi

    • PubMed: 35964137
    • DOI: 10.1186/s13063-022-06621-1

    5 Insights on

    • Reduced Myocardial Injury
    • Reduced Liver Injury Marker
    • Reduced Organ Failure Severity
    • Reduced Hospital Stay
    • Reduced Intensive Care Unit Stay

    • High evidence
• August 17

  • Efficacy of 12 weeks oral beta-alanine supplementation in patients with chronic obstructive pulmonary disease: a double-blind, randomized, placebo-controlled trial.

    • 2022-08-17
    • RCT · n = 40
    • Journal of cachexia, sarcopenia and muscle 13(5)
    • • Jana De Brandt
      • Wim Derave
      • Frank Vandenabeele
      • Pascal Pomiès
      • Laura Blancquaert
      • Charly Keytsman
      • Marina S Barusso-Grüninger
      • Fabiano F de Lima
      • Maurice Hayot
      • Martijn A Spruit
      • Chris Burtin

    • PubMed: 35977911
    • DOI: 10.1002/jcsm.13048

    11 Insights on

    • Increased Time to Exhaustion
    • Increased Carnosine Level
    • Improved Maximal Exercise Capacity
    • Improved Constant Work Rate Exercise Time
    • Improved Quadriceps Function
    • Reduced Muscle Oxidative Stress
    • Reduced Muscle Carbonyl Stress
    • Increased VO2 Peak
    • Increased Maximal Incremental Cycling Capacity
    • Improved Quadriceps Strength
    • Improved Quadriceps Endurance

    • High evidence
• August 19

  • Metabolite Pattern Derived from Lactiplantibacillus plantarum-Fermented Rye Foods and In Vitro Gut Fermentation Synergistically Inhibits Bacterial Growth.

    • 2022-08-19
    • Molecular nutrition & food research 66(21)
    • • Ville M Koistinen
      • Maria Hedberg
      • Lin Shi
      • Anders Johansson
      • Otto Savolainen
      • Marko Lehtonen
      • Anna-Marja Aura
      • Kati Hanhineva
      • Rikard Landberg

    • PubMed: 35960594
    • DOI: 10.1002/mnfr.202101096

    2 Insights on

    • Modulated Gut Microbiota
    • Reduced Pathogenic Bacterial Growth

    • Low evidence
    • Rigorous Journal

  • Use of the Probiotic Bifidobacterium animalis subsp. lactis HN019 in Oral Diseases

    • 2022-08-19
    • Review
    • International Journal of Molecular Sciences 23(16)
    • • Lisa Danielly Curcino Araújo
      • F. Furlaneto
      • L. A. D. Da Silva
      • Y. Kapila

    • PubMed: 36012597
    • DOI: 10.3390/ijms23169334

    2 Insights on

    • Modulated Immune Response
    • Improved Periodontal Health

    • Low evidence
• August 21

  • Anticandidal and Antibiofilm Effect of Synbiotics including Probiotics and Inulin-Type Fructans.

    • 2022-08-21
    • Antibiotics (Basel, Switzerland) 11(8)
    • • Ricardo García-Gamboa
      • Miguel Domínguez-Simi
      • Misael S Gradilla-Hernández
      • Jorge Bravo
      • Andrés Moya
      • Blanca Ruiz-Álvarez
      • Marisela González-Avila

    • PubMed: 36010004
    • DOI: 10.3390/antibiotics11081135

    1 Insight on

    • Reduced Candida albicans Growth

    • Low evidence
• August 22

  • Nutrition and mental health: A review of current knowledge about the impact of diet on mental health.

    • 2022-08-22
    • Review
    • Frontiers in nutrition 9
    • • Mateusz Grajek
      • Karolina Krupa-Kotara
      • Agnieszka Białek-Dratwa
      • Karolina Sobczyk
      • Martina Grot
      • Oskar Kowalski
      • Wiktoria Staśkiewicz

    • PubMed: 36071944
    • DOI: 10.3389/fnut.2022.943998

    1 Insight on

    • Improved Mental Health

    • Low evidence

  • A Multi-Strain Probiotic Formulation Improves Intestinal Barrier Function by the Modulation of Tight and Adherent Junction Proteins.

    • 2022-08-22
    • Cells 11(16)
    • • Raffaella di Vito
      • Carmela Conte
      • Giovanna Traina

    • PubMed: 36010692
    • DOI: 10.3390/cells11162617

    2 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Intestinal Damage

    • Low evidence
• August 23

  • The Mechanisms of the Potential Probiotic Lactiplantibacillus plantarum against Cardiovascular Disease and the Recent Developments in its Fermented Foods

    • 2022-08-23
    • Foods 11(17)
    • • Zhe Wang
      • Juanjuan Wu
      • Zichen Tian
      • Y. Si
      • Hao Chen
      • Jing Gan

    • PubMed: 36076735
    • DOI: 10.3390/foods11172549

    4 Insights on

    • Reduced Blood Glucose Levels
    • Reduced Lipid Levels
    • Reduced Incidence of Cardiovascular Disease
    • Regulated Blood Pressure

    • Low evidence
    • Rigorous Journal
• August 24

  • Functional Annotation of Lactiplantibacillus plantarum 13-3 as a Potential Starter Probiotic Involved in the Food Safety of Fermented Products

    • 2022-08-24
    • Molecules 27(17)
    • • T. Aziz
      • M. Naveed
      • A. Sarwar
      • Syeda Izma Makhdoom
      • Muhammad Saad Mughal
      • Urooj Ali
      • Zhennai Yang
      • M. Shahzad
      • M. Sameeh
      • Mashael W Alruways
      • Anas S. Dablool
      • Abdulraheem A Almalki
      • A. Alamri
      • M. Alhomrani

    • PubMed: 36080167
    • DOI: 10.3390/molecules27175399

    2 Insights on

    • Improved Digestive Health
    • Enhanced Immunity

    • Low evidence

  • The Detection of Potential Native Probiotics Lactobacillus spp. against Salmonella Enteritidis, Salmonella Infantis and Salmonella Kentucky ST198 of Lebanese Chicken Origin.

    • 2022-08-24
    • Antibiotics (Basel, Switzerland) 11(9)
    • • Rima El Hage
      • Jeanne El Hage
      • Selma P Snini
      • Imad Ammoun
      • Joseph Touma
      • Rami Rachid
      • Florence Mathieu
      • Jean-Marc Sabatier
      • Ziad Abi Khattar
      • Youssef El Rayess

    • PubMed: 36139927
    • DOI: 10.3390/antibiotics11091147

    1 Insight on

    • Reduced Salmonella Paratyphi Growth

    • Low evidence

  • Immunomodulatory effects of the Bifidobacterium longum BL-10 on lipopolysaccharide-induced intestinal mucosal immune injury

    • 2022-08-24
    • Clinical Trial
    • Frontiers in Immunology 13
    • • Jiahuan Dong
      • Lijun Ping
      • Ting Cao
      • Le-Hang Sun
      • Deyu Liu
      • Song Wang
      • G. Huo
      • Bailiang Li

    • PubMed: 36091059
    • DOI: 10.3389/fimmu.2022.947755

    5 Insights on

    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Myeloperoxidase Levels
    • Increased Granulocyte Count
    • Enhanced Beneficial Gut Microbiota
    • Reduced Intestinal Tissue Injury

    • Low evidence
    • Animal Study
• August 26

  • Bacillus clausii for Gastrointestinal Disorders: A Narrative Literature Review.

    • 2022-08-26
    • Review
    • Advances in therapy 39(11)
    • • Carlos Patricio Acosta-Rodríguez-Bueno
      • Ana Teresa Abreu Y Abreu
      • Francisco Guarner
      • Mary Jean V Guno
      • Ender Pehlivanoğlu
      • Marcos Perez

    • PubMed: 36018495
    • DOI: 10.1007/s12325-022-02285-0

    1 Insight on

    • Improved Gastrointestinal Symptoms

    • Low evidence

  • Bacteraemia Caused by Probiotic Strains of Lacticaseibacillus rhamnosus—Case Studies Highlighting the Need for Careful Thought before Using Microbes for Health Benefits

    • 2022-08-26
    • Case Report · n = 2
    • Pathogens 11(9)
    • • Agnieszka Mikucka
      • A. Deptuła
      • Tomasz Bogiel
      • A. Chmielarczyk
      • Elżbieta Nurczyńska
      • E. Gospodarek-Komkowska

    • PubMed: 36145409
    • DOI: 10.3390/pathogens11090977

    2 Insights on

    • Increased Bacteremia
    • Incidence of Endocarditis

    • Low evidence
• August 29

  • Effect of Probiotics on Host-Microbiota in Bacterial Infections.

    • 2022-08-29
    • Review
    • Pathogens (Basel, Switzerland) 11(9)
    • • Ascensión Rueda-Robles
      • Avilene Rodríguez-Lara
      • Matthew S Meyers
      • María José Sáez-Lara
      • Ana I Álvarez-Mercado

    • PubMed: 36145418
    • DOI: 10.3390/pathogens11090986

    4 Insights on

    • Improved Gut Microbiota
    • Reduced Pathogen Growth
    • Modulated Gut Microbiota
    • Reduced Pathogenic Bacteria Load

    • Low evidence

  • Anti-Tumor Effect of Heat-Killed Bifidobacterium bifidum on Human Gastric Cancer through Akt-p53-Dependent Mitochondrial Apoptosis in Xenograft Models

    • 2022-08-29
    • Clinical Trial
    • International Journal of Molecular Sciences 23(17)
    • • SukJin Kim
      • H. H. Lee
      • Wonhyeok Choi
      • Chang-Ho Kang
      • Gun-Hee Kim
      • Hyosun Cho

    • PubMed: 36077182
    • DOI: 10.3390/ijms23179788

    1 Insight on

    • Reduced Tumor Growth

    • Low evidence
    • Animal Study
• August 30

  • Eco-Friendly Edible Packaging Systems Based on Live-Lactobacillus kefiri MM5 for the Control of Listeria monocytogenes in Fresh Vegetables.

    • 2022-08-30
    • Foods (Basel, Switzerland) 11(17)
    • • Ramona Iseppi
      • Chiara Zurlini
      • Ilaria Maria Cigognini
      • Mariarosaria Cannavacciuolo
      • Carla Sabia
      • Patrizia Messi

    • PubMed: 36076818
    • DOI: 10.3390/foods11172632

    1 Insight on

    • Reduced Listeria Monocytogenes Population

    • Low evidence
• August 31

  • Bacillus coagulans in Combination with Chitooligosaccharides Regulates Gut Microbiota and Ameliorates the DSS-Induced Colitis in Mice

    • 2022-08-31
    • Clinical Trial
    • Microbiology Spectrum 10(4)
    • • Zhenzhen Liu
      • Ziyang Jiang
      • Zhenting Zhang
      • Tong Liu
      • Yurong Fan
      • Tao Liu
      • Nan Peng

    • PubMed: 35900082
    • DOI: 10.1128/spectrum.00641-22

    9 Insights on

    • Improved Gut Microbiota Composition
    • Improved Intestinal Barrier Function
    • Reduced Colitis Symptoms
    • Maintained Intestinal Barrier Function
    • Improved Inflammatory Status
    • Reduced Inflammatory Status
    • Reduced Disease Activity in Ulcerative Colitis
    • Modulated Inflammatory Cytokine Levels
    • Modulated Cytokine Levels

    • Low evidence
    • Animal Study

  • AI-2/LuxS Quorum Sensing System Promotes Biofilm Formation of Lactobacillus rhamnosus GG and Enhances the Resistance to Enterotoxigenic Escherichia coli in Germ-Free Zebrafish

    • 2022-08-31
    • Clinical Trial
    • Microbiology Spectrum 10(4)
    • • Zhaoxi Deng
      • K. Hou
      • T. Valencak
      • Xin M. Luo
      • Jianxin Liu
      • Haifeng Wang

    • PubMed: 35700135
    • DOI: 10.1128/spectrum.00610-22

    4 Insights on

    • Reduced Inflammation
    • Improved Biofilm Development
    • Increased Resistance to ETEC Infection
    • Improved Colonization Efficiency

    • Low evidence
    • Animal Study

  • Lactobacillus rhamnosus HN001 Ameliorates BEZ235-Induced Intestinal Dysbiosis and Prolongs Cardiac Transplant Survival

    • 2022-08-31
    • Clinical Trial
    • Microbiology Spectrum 10(4)
    • • Xiaolong Miao
      • Yuancong Jiang
      • Deqiang Kong
      • Zelai Wu
      • Han Liu
      • Xiaolin Ye
      • W. Gong

    • PubMed: 35862958
    • DOI: 10.1128/spectrum.00794-22

    4 Insights on

    • Reduced Dysbiosis
    • Increased Activation of Regulatory T Cells
    • Extended Cardiac Transplant Survival
    • Restored Intestinal Microbiota Balance

    • Low evidence
    • Animal Study
• Undated – 3 supplement studies

  • Therapeutic effect of heat-killed Lactobacillus plantarum L-137 on the gut health and growth of broilers.

    • 2022-08
    • RCT
    • Acta tropica 232
    • • Hai Ha Pham Thi
      • Tuong Vi Phan Thi
      • Ninh Pham Huynh
      • Vinh Doan
      • Satoru Onoda
      • Thanh Luan Nguyen

    • PubMed: 35623400
    • DOI: 10.1016/j.actatropica.2022.106537

    3 Insights on

    • Improved Immune Response
    • Improved Gut Morphology
    • Reduced Mortality Risk

    • Low evidence
    • Animal Study

  • Effect of the addition of the probiotic Bifidobacterium animalis subsp. Lactis (BB-12) in free and microencapsulated form and the prebiotic inulin to synbiotic dry coppa.

    • 2022-08
    • Food research international (Ottawa, Ont.) 158
    • • Talita Aparecida Ferreira de Campos
      • Annecler Rech de Marins
      • Natallya Marques da Silva
      • Marcos Antonio Matiucci
      • Iza Catarini Dos Santos
      • Claudete Regina Alcalde
      • Maria Luiza Rodrigues de Souza
      • Raquel Guttierres Gomes
      • Andresa Carla Feihrmann

    • PubMed: 35840239
    • DOI: 10.1016/j.foodres.2022.111544

    3 Insights on

    • Reduced Lipid Oxidation
    • Improved Gastrointestinal Survival
    • Reduced Protein Oxidation

    • Low evidence

  • Safety and efficacy of a feed additive consisting of Limosilactobacillus reuteri (formerly Lactobacillus reuteri) DSM 32264 as a feed additive for cats (NBF Lanes s.r.l.)

    • 2022-08
    • EFSA Journal 20(8)
    • • V. Bampidis
      • G. Azimonti
      • M. Bastos
      • Henrik Christensen
      • Birgit Dusemund
      • Mojca Fašmon Durjava
      • M. Kouba
      • M. López-Alonso
      • Secundino López Puente
      • F. Marcon
      • B. Mayo
      • A. Pechová
      • M. Petkova
      • F. Ramos
      • Yolanda Sanz
      • R. Villa
      • R. Woutersen
      • G. Martelli
      • M. Anguita
      • J. Galobart
      • J. Ortuño
      • J. Revez
      • Rosella Brozzi

    • PubMed: 35949936
    • DOI: 10.2903/j.efsa.2022.7437

    2 Insights on

    • Improved Stool Consistency
    • Increased Constipation Risk

    • Low evidence