January 2019 Supplement Research Papers

• January 1

  • Fisetin Prolongs Therapy Window of Brain Ischemic Stroke Using Tissue Plasminogen Activator: A Double-Blind Randomized Placebo-Controlled Clinical Trial.

    • 2019-01-01
    • RCT
    • Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 25
    • • Limin Wang
      • Di Cao
      • Huijun Wu
      • Hongning Jia
      • Chaoping Yang
      • Lihua Zhang

    • PubMed: 31434498
    • DOI: 10.1177/1076029619871359

    4 Insights on

    • Reduced Matrix Metalloproteinase-9 Level
    • Reduced National Institutes of Health Stroke Scale Score
    • Reduced C-Reactive Protein Levels
    • Reduced Matrix Metalloproteinase-2 Level

    • High evidence
• January 4

  • Lactobacillus bulgaricus or Lactobacillus rhamnosus Suppresses NF-κB Signaling Pathway and Protects against AFB1-Induced Hepatitis: A Novel Potential Preventive Strategy for Aflatoxicosis?

    • 2019-01-04
    • Clinical Trial
    • Toxins 11(1)
    • • Yuanyuan Chen
      • Ruirui Li
      • Qiaocheng Chang
      • Zhihao Dong
      • Huanmin Yang
      • Chuang Xu

    • PubMed: 30621122
    • DOI: 10.3390/toxins11010017

    5 Insights on

    • Prevented Liver Injury
    • Liver Protection from Aflatoxin B1 Damage
    • Reduced Liver Inflammation
    • Reduced Inflammatory Response
    • Reduced AFB1-Induced Liver Damage

    • Low evidence
    • Animal Study

  • Consumption of a Fermented Milk Product Containing Bifidobacterium lactis CNCM I-2494 in Women Complaining of Minor Digestive Symptoms: Rapid Response Which Is Independent of Dietary Fibre Intake or Physical Activity

    • 2019-01-04
    • Meta-Analysis
    • Nutrients 11(1)
    • • P. Marteau
      • B. Le Nevé
      • L. Quinquis
      • Caroline Pichon
      • P. Whorwell
      • D. Guyonnet

    • PubMed: 30621211
    • DOI: 10.3390/nu11010092

    3 Insights on

    • Reduced Digestive Symptoms
    • Reduced Minor Digestive Symptoms
    • Improved Digestive Symptoms

    • High evidence
• January 5

  • Acetyl-L-carnitine for patients with hepatic encephalopathy.

    • 2019-01-05
    • Meta-Analysis · n = 398
    • The Cochrane database of systematic reviews 2019(1)
    • • Arturo J Martí-Carvajal
      • Christian Gluud
      • Ingrid Arevalo-Rodriguez
      • Cristina Elena Martí-Amarista

    • PubMed: 30610762
    • DOI: 10.1002/14651858.cd011451.pub2

    4 Insights on

    • Reduced Mental Fatigue
    • Worsened General Health
    • Reduced Ammonium Level
    • Reduced Fatigue

    • High evidence

  • Intraduodenal Administration of L-Valine Has No Effect on Antropyloroduodenal Pressures, Plasma Cholecystokinin Concentrations or Energy Intake in Healthy, Lean Men.

    • 2019-01-05
    • RCT
    • Nutrients 11(1)
    • • Rachel A Elovaris
      • Penelope C E Fitzgerald
      • Vida Bitarafan
      • Sina S Ullrich
      • Michael Horowitz
      • Christine Feinle-Bisset

    • PubMed: 30621276
    • DOI: 10.3390/nu11010099

    8 Insights on

    • Reduced Duodenal Pressure
    • Reduced Blood Glucose Levels
    • Reduced Antral Pressure
    • Reduced Appetite
    • Reduced Pyloric Pressure
    • Reduced Gastrointestinal Symptoms
    • Reduced Energy Intake
    • Reduced Cholecystokinin Level

    • High evidence
    • Rigorous Journal
• January 7

  • Probiotic Lactobacillus johnsonii BS15 Promotes Growth Performance, Intestinal Immunity, and Gut Microbiota in Piglets

    • 2019-01-07
    • RCT
    • Probiotics and Antimicrobial Proteins 12(1)
    • • Jinge Xin
      • Dong Zeng
      • Hesong Wang
      • Ning Sun
      • Ying Zhao
      • Yan Dan
      • Kangcheng Pan
      • Bo Jing
      • Xueqin Ni

    • PubMed: 30617949
    • DOI: 10.1007/s12602-018-9511-y

    6 Insights on

    • Increased Fecal Secretory IgA Levels
    • Improved Daily Weight Gain
    • Improved Intestinal Immunity
    • Altered T Cell Subsets
    • Reduced Diarrhea Incidence
    • Reduced Diarrhea Rate

    • High evidence
• January 8

  • Beneficial Effects of Natural Bioactive Compounds from Hibiscus sabdariffa L. on Obesity.

    • 2019-01-08
    • Review
    • Molecules (Basel, Switzerland) 24(1)
    • • Oyindamola Vivian Ojulari
      • Seul Gi Lee
      • Ju-Ock Nam

    • PubMed: 30626104
    • DOI: 10.3390/molecules24010210

    3 Insights on

    • Reduced Body Weight
    • Suppressed Adipogenesis
    • Reduced Liver Lipid Accumulation

    • Low evidence

  • Bacillus amyloliquefaciens Ameliorates Dextran Sulfate Sodium-Induced Colitis by Improving Gut Microbial Dysbiosis in Mice Model

    • 2019-01-08
    • Clinical Trial
    • Frontiers in Microbiology 9
    • • G. Cao
      • Kangli Wang
      • Zhanming Li
      • Fei Tao
      • Yinglei Xu
      • J. Lan
      • Guangyong Chen
      • Caimei Yang

    • PubMed: 30671050
    • DOI: 10.3389/fmicb.2018.03260

    4 Insights on

    • Improved Body Weight
    • Improved Gut Morphology
    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Disease Activity Index (DAI) Levels

    • Low evidence
    • Animal Study
• January 9

  • Use of Lactobacillus crispatus to produce a probiotic cheese as potential gender food for preventing gynaecological infections

    • 2019-01-09
    • PLOS ONE 14(1)
    • • F. Patrignani
      • L. Siroli
      • C. Parolin
      • D. Serrazanetti
      • B. Vitali
      • R. Lanciotti

    • PubMed: 30625157
    • DOI: 10.1371/journal.pone.0208906

    8 Insights on

    • Improved Dietary Acceptability
    • Reduced Incidence of Gynaecological Infections
    • Acceptability of Cheese Products
    • Viability of Probiotic Bacteria in Cheese
    • Improved Acceptability of Dairy Products
    • Improved Food Acceptability
    • Reduced Risk of Gynaecological Infections
    • High Viability of Probiotic Lactobacillus crispatus BC4 in Cheese

    • Low evidence
    • Rigorous Journal

  • N-Alkylamides from Piper longum L. and their stimulative effects on the melanin content and tyrosinase activity in B16 melanoma cells

    • 2019-01-09
    • Natural Product Research 34(17)
    • • S. Abdubakiev
      • Hongliang Li
      • Xue-ying Lu
      • Jun Li
      • H. Aisa

    • PubMed: 30623685
    • DOI: 10.1080/14786419.2018.1539982

    1 Insight on

    • Increased Melanin Content

    • Low evidence
• January 10

  • Prophylactic Therapy of Silymarin (Milk Thistle) on Antituberculosis Drug-Induced Liver Injury: A Meta-Analysis of Randomized Controlled Trials.

    • 2019-01-10
    • Meta-Analysis · n = 1,198
    • Canadian journal of gastroenterology & hepatology 2019
    • • Lina Tao
      • Xiaoyu Qu
      • Yue Zhang
      • Yanqing Song
      • Si-Xi Zhang

    • PubMed: 30733935
    • DOI: 10.1155/2019/3192351

    4 Insights on

    • Reduced Aspartate Aminotransferase Level
    • Reduced Alkaline Phosphatase Level
    • Reduced Alanine Aminotransferase Level
    • Reduced Antituberculosis Drug-Induced Liver Injury

    • High evidence
• January 13

  • Berberine and barberry (Berberis vulgaris): A clinical review.

    • 2019-01-13
    • Review
    • Phytotherapy research : PTR 33(3)
    • • Mohsen Imenshahidi
      • Hossein Hosseinzadeh

    • PubMed: 30637820
    • DOI: 10.1002/ptr.6252

    2 Insights on

    • Reduced Lipid Level
    • Improved Insulin Sensitivity

    • Moderate evidence
    • Highly Cited
• January 15

  • The effect of L-theanine supplementation on the immune system of athletes exposed to strenuous physical exercise.

    • 2019-01-15
    • RCT · n = 10
    • Journal of the International Society of Sports Nutrition 16(1)
    • • A Juszkiewicz
      • A Glapa
      • P Basta
      • E Petriczko
      • K Żołnowski
      • B Machaliński
      • J Trzeciak
      • K Łuczkowska
      • A Skarpańska-Stejnborn

    • PubMed: 30770758
    • DOI: 10.1186/s12970-019-0274-y

    6 Insights on

    • Reduced Regulatory T Cell to Natural Killer Cell Ratio
    • Increased Regulatory T Cell Count
    • Reduced Interleukin-10 Level
    • Reduced Cytotoxic Lymphocyte Count
    • Increased Interferon Gamma to Interleukin 10 Ratio
    • Increased Interleukin-2 to Interleukin-10 Ratio

    • High evidence
• January 17

  • Intestinal Morphologic and Microbiota Responses to Dietary Bacillus spp. in a Broiler Chicken Model

    • 2019-01-17
    • RCT
    • Frontiers in Physiology 9
    • • Cheng-liang Li
      • Jing Wang
      • Haijun Zhang
      • Shu-geng Wu
      • Qian-ru Hui
      • Cheng-bo Yang
      • Re-jun Fang
      • G. Qi

    • PubMed: 30705639
    • DOI: 10.3389/fphys.2018.01968

    6 Insights on

    • Increased Body Weight
    • Improved Intestinal Morphology
    • Increased Villus Height to Crypt Depth Ratio
    • Improved Growth Performance
    • Improved Nutrient Digestibility
    • Increased Average Daily Weight Gain

    • High evidence
    • Highly Cited

  • Investigation of the Efficacy of Lactobacillus rhamnosus GG in Infants With Cow's Milk Protein Allergy: a Randomised Double-Blind Placebo-Controlled Trial.

    • 2019-01-17
    • RCT
    • Probiotics and antimicrobial proteins 12(1)
    • • Ahmet Basturk
      • İshak Isik
      • Atike Atalay
      • Aygen Yılmaz

    • PubMed: 30656549
    • DOI: 10.1007/s12602-019-9516-1

    9 Insights on

    • Reduced Abdominal Distension
    • Reduced Constipation
    • Reduced Bloody Stool
    • Reduced Vomiting
    • Reduced Diarrhea
    • Reduced Dermatitis
    • Reduced Mucousy Stool
    • Reduced Restiveness
    • Reduced Abdominal Pain

    • High evidence
    • Rigorous Journal

  • Treatment of military acoustic accidents with N-Acetyl-L-cysteine (NAC).

    • 2019-01-17
    • Observational
    • International journal of audiology 58(3)
    • • Ulf Rosenhall
      • Björn Skoog
      • Per Muhr

    • PubMed: 30653365
    • DOI: 10.1080/14992027.2018.1543961

    1 Insight on

    • Reduced Temporary Hearing Loss

    • Low evidence
• January 18

  • Lactobacillus reuteri KT260178 Supplementation Reduced Morbidity of Piglets Through Its Targeted Colonization, Improvement of Cecal Microbiota Profile, and Immune Functions

    • 2019-01-18
    • RCT · n = 60
    • Probiotics and Antimicrobial Proteins 12(1)
    • • Jiajun Yang
      • Chonglong Wang
      • Linqing Liu
      • Min-hong Zhang

    • PubMed: 30659502
    • DOI: 10.1007/s12602-019-9514-3

    6 Insights on

    • Improved Growth
    • Improved Immune Function
    • Improved Growth Rate
    • Improved Total Antioxidant Status
    • Improved Microbiota Profile
    • Reduced Morbidity Rate

    • Low evidence
    • Animal Study
• January 19

  • Effect of yerba mate and green tea on paraoxonase and leptin levels in patients affected by overweight or obesity and dyslipidemia: a randomized clinical trial.

    • 2019-01-19
    • RCT · n = 142
    • Nutrition journal 18(1)
    • • Guilherme Balsan
      • Lúcia Campos Pellanda
      • Grasiele Sausen
      • Thaís Galarraga
      • Denise Zaffari
      • Bruna Pontin
      • Vera Lúcia Portal
      • Vera Lúcia Portal

    • PubMed: 30660196
    • DOI: 10.1186/s12937-018-0426-y

    2 Insights on

    • Increased Paraoxonase-1 Level
    • Reduced Uric Acid Levels

    • High evidence
    • Large Human Trial
• January 21

  • A human origin strain Lactobacillus acidophilus DDS-1 exhibits superior in vitro probiotic efficacy in comparison to plant or dairy origin probiotics

    • 2019-01-21
    • International Journal of Medical Sciences 15(9)
    • • R. Vemuri
      • Tanvi Shinde
      • M. Shastri
      • A. P. Perera
      • S. Tristram
      • C. Martoni
      • R. Gundamaraju
      • K. Ahuja
      • Madeleine Ball
      • R. Eri

    • PubMed: 30008595
    • DOI: 10.7150/ijms.25004

    3 Insights on

    • Reduced IL-8 Levels
    • Improved Survival Under Gastrointestinal Conditions
    • Modulated Cytokine Levels

    • Low evidence
    • Rigorous Journal

  • Lactobacillus reuteri DSM 17938 Protects against Gastric Damage Induced by Ethanol Administration in Mice: Role of TRPV1/Substance P Axis

    • 2019-01-21
    • Clinical Trial
    • Nutrients 11(1)
    • • Ana P. Oliveira
      • L. K. Souza
      • Thiago S L Araújo
      • Simone Rocha de Araújo
      • K. M. Nogueira
      • F. B. Sousa
      • R. O. Silva
      • Dvison M. Pacífico
      • C. Martins
      • G. Brito
      • M. Souza
      • J. Medeiros

    • PubMed: 30669695
    • DOI: 10.3390/nu11010208

    3 Insights on

    • Reduced Hepatic Oxidative Stress
    • Reduced Gastric Ulcer Area
    • Reduced Substance P Levels

    • Low evidence
    • Animal Study

  • Soluble Lactobacillus delbrueckii subsp. bulgaricus 92059 PrtB proteinase derivatives for production of bioactive peptide hydrolysates from casein

    • 2019-01-21
    • Applied Microbiology and Biotechnology 103(6)
    • • Bo Li
      • D. Habermann
      • T. Kliche
      • M. Klempt
      • A. Wutkowski
      • I. Clawin‐Rädecker
      • S. Koberg
      • E. Brinks
      • T. Koudelka
      • Andreas Tholey
      • W. Bockelmann
      • C. Franz
      • Knut J. Heller

    • PubMed: 30666364
    • DOI: 10.1007/s00253-018-09586-x

    5 Insights on

    • Reduced Hypertension
    • Reduced Angiotensin I-Converting Enzyme Activity
    • Enhanced Immunomodulation
    • Reduced Inflammatory Activities
    • Reduced Inflammation Levels

    • Low evidence
• January 22

  • Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1.

    • 2019-01-22
    • RCT · n = 18
    • Neurology 92(4)
    • • Vera Fridman
      • Saranya Suriyanarayanan
      • Peter Novak
      • William David
      • Eric A Macklin
      • Diane McKenna-Yasek
      • Kailey Walsh
      • Razina Aziz-Bose
      • Anne Louise Oaklander
      • Robert Brown
      • Thorsten Hornemann
      • Florian Eichler

    • PubMed: 30626650
    • DOI: 10.1212/wnl.0000000000006811

    2 Insights on

    • Reduced Deoxysphinganine Level
    • Improved Charcot-Marie-Tooth Neuropathy Score

    • High evidence

  • Effects of Tart Cherry Juice on Biomarkers of Inflammation and Oxidative Stress in Older Adults.

    • 2019-01-22
    • RCT · n = 37
    • Nutrients 11(2)
    • • Sheau C Chai
      • Kristina Davis
      • Zugui Zhang
      • Longying Zha
      • Kenneth F Kirschner

    • PubMed: 30678193
    • DOI: 10.3390/nu11020228

    4 Insights on

    • Reduced Oxidized Low-Density Lipoprotein Level
    • Reduced Malondialdehyde Level
    • Increased DNA Repair Activity
    • Reduced C-Reactive Protein Levels

    • High evidence
    • Rigorous Journal

  • A randomized, double blind, placebo controlled, multicenter clinical trial to assess the efficacy and safety of Emblica officinalis extract in patients with dyslipidemia.

    • 2019-01-22
    • RCT · n = 98
    • BMC complementary and alternative medicine 19(1)
    • • Haridas Upadya
      • S Prabhu
      • Aravinda Prasad
      • Deepa Subramanian
      • Swati Gupta
      • Ajay Goel

    • PubMed: 30670010
    • DOI: 10.1186/s12906-019-2430-y

    7 Insights on

    • Reduced Triglyceride Levels
    • Reduced Fasting Blood Glucose Levels
    • Reduced Apo B to Apo A1 Ratio
    • Reduced Blood Cholesterol
    • Reduced LDL Cholesterol
    • Reduced Atherogenic Index
    • Reduced Coenzyme Q10 Level

    • High evidence
• January 29

  • Saccharomyces boulardii CNCM I-745 plus sequential therapy for Helicobacter pylori infections: a randomized, open-label trial.

    • 2019-01-29
    • RCT · n = 199
    • European journal of clinical pharmacology 75(5)
    • • Hassan Seddik
      • Hanae Boutallaka
      • Ilham Elkoti
      • Fouad Nejjari
      • Reda Berraida
      • Sanaa Berrag
      • Khaoula Loubaris
      • Sara Sentissi
      • Ahmed Benkirane

    • PubMed: 30694338
    • DOI: 10.1007/s00228-019-02625-0

    1 Insight on

    • Increased Helicobacter pylori Eradication Rate

    • High evidence
    • Large Human Trial
• January 31

  • Mechanisms underlying effects of kiwifruit on intestinal function shown by MRI in healthy volunteers.

    • 2019-01-31
    • RCT
    • Alimentary pharmacology & therapeutics 49(6)
    • • Victoria Wilkinson-Smith
      • Neele Dellschaft
      • Juliet Ansell
      • Caroline Hoad
      • Luca Marciani
      • Penny Gowland
      • Robin Spiller

    • PubMed: 30706488
    • DOI: 10.1111/apt.15127

    7 Insights on

    • Increased Small Bowel Water Content
    • Increased Fecal Water Content
    • Improved Stool Consistency
    • Reduced Gut Transit Time
    • Increased Water Content in Descending Colon
    • Improved Bowel Movement Frequency
    • Increased Colonic Volume

    • High evidence
    • Rigorous Journal
• Undated – 17 supplement studies

  • Mechanisms of Action of Probiotics.

    • 2019-01
    • Review
    • Advances in nutrition (Bethesda, Md.) 10
    • • Julio Plaza-Diaz
      • Francisco Javier Ruiz-Ojeda
      • Mercedes Gil-Campos
      • Angel Gil

    • PubMed: 30721959
    • DOI: 10.1093/advances/nmy063

    4 Insights on

    • Improved Immune Function
    • Improved Digestive Health
    • Improved Gastrointestinal Symptoms
    • Improved Intestinal Microbiota Balance

    • Moderate evidence
    • Highly Cited

  • A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity.

    • 2019-01
    • Clinical Trial
    • Cell Host & Microbe 25(1)
    • • Daniel F. Zegarra-Ruiz
      • Asmaa El Beidaq
      • A. Iñiguez
      • Martina Lubrano di Ricco
      • S. Manfredo Vieira
      • W. Ruff
      • Derek L Mubiru
      • Rebecca L. Fine
      • John A. Sterpka
      • T. Greiling
      • C. Dehner
      • M. Kriegel

    • PubMed: 30581114
    • DOI: 10.1016/j.chom.2018.11.009

    1 Insight on

    • Worsened Autoimmune Manifestations

    • Low evidence
    • Highly Cited
    • Animal Study

  • Yogurt starter cultures of Streptococcus thermophilus and Lactobacillus bulgaricus ameliorate symptoms and modulate the immune response in a mouse model of dextran sulfate sodium-induced colitis.

    • 2019-01
    • Journal of Dairy Science 102(1)
    • • Ewa Wasilewska
      • D. Złotkowska
      • Barbara Wróblewska

    • PubMed: 30343915
    • DOI: 10.3168/jds.2018-14520

    18 Insights on

    • Improved Disease Activity Index Score
    • Increased Anti-inflammatory Cytokines
    • Reduced IFN-γ in Serum
    • Reduced Body Weight Loss
    • Improved Regulatory T Cell Function
    • Increased Colon Length
    • Improved Microbial Diversity
    • Reduced Disease Symptoms
    • Improved IgA Production
    • Enhanced Regulatory T Cell Function
    • Modulated Cytokine Production
    • Improved Immune Modulation
    • Reduced Myeloperoxidase Activity
    • Reduced Cytotoxic T Cells in Peyer's Patches
    • Reduced Disease Activity in Colitis
    • Elevated Serum IL-2 Levels
    • Increased Immunoglobulin A (IgA) Production
    • Reduced Putrefactive Short-Chain Fatty Acids

    • Low evidence
    • Rigorous Journal

  • Characterization of Bacillus subtilis from gastrointestinal tract of hybrid Hulong grouper (Epinephelus fuscoguttatus × E. lanceolatus) and its effects as probiotic additives.

    • 2019-01
    • Clinical Trial
    • Fish & Shellfish Immunology 84
    • • Sheng Zhou
      • D. Song
      • Xiaofeng Zhou
      • Xinliang Mao
      • Xuefeng Zhou
      • Sunli Wang
      • Jingguang Wei
      • Youhua Huang
      • Wenxiong Wang
      • S. Xiao
      • Q. Qin

    • PubMed: 30463174
    • DOI: 10.1016/j.fsi.2018.10.058

    14 Insights on

    • Enhanced Innate Immune Function
    • Enhanced Phagocytic Activity of Head Kidney Leukocytes
    • Increased Serum Alternative Complement Activity
    • Improved Immune Function
    • Improved Phagocytic Activity of Head Kidney Leukocytes
    • Improved Antibacterial Activity
    • Improved Specific Growth Rate
    • Improved Resistance to Iridovirus
    • Enhanced Respiratory Burst Activity
    • Reduced Incidence of Infections
    • Increased Superoxide Dismutase Activity
    • Increased Serum Lysozyme Activity
    • Improved Nonspecific Humoral Response
    • Enhanced Growth Rate

    • Low evidence
    • Animal Study

  • Dietary Lactobacillus plantarum ST-III alleviates the toxic effects of triclosan on zebrafish (Danio rerio) via gut microbiota modulation.

    • 2019-01
    • Clinical Trial
    • Fish & Shellfish Immunology 84
    • • Luxiu Zang
      • Yan Ma
      • Wenhao Huang
      • Yuhang Ling
      • Limei Sun
      • Xuedong Wang
      • Aibing Zeng
      • R. Dahlgren
      • Caihong Wang
      • Huili Wang

    • PubMed: 30423455
    • DOI: 10.1016/j.fsi.2018.11.007

    13 Insights on

    • Reduced Pro-Inflammatory Cells
    • Restored Lipid Metabolism
    • Improved Behavioral Health
    • Reduced CD4+ T Cell Lymphocytes in Intestinal Mucosa
    • Reduced Inflammation
    • Reduced Malonaldehyde Levels
    • Reduced Bacterial Toxin Production
    • Alleviated Intestinal Metabolic Disorders
    • Enhanced Gut Microbiota Diversity
    • Reduced Toxicity
    • Improved Lipid Metabolism
    • Improved Gut Microbiota Diversity
    • Reduced Inflammation Levels

    • Low evidence
    • Animal Study

  • Effects of applying Lactobacillus helveticus H9 as adjunct starter culture in yogurt fermentation and storage.

    • 2019-01
    • Journal of Dairy Science 102(1)
    • • Tingting Zhou
      • Rui Huo
      • L. Kwok
      • Changkun Li
      • Yuzhu Ma
      • ZhiHui Mi
      • Yongfu Chen

    • PubMed: 30343912
    • DOI: 10.3168/jds.2018-14602

    3 Insights on

    • Increased ACE Inhibitor Activity
    • Improved Gastric Acid Regulation
    • Improved Antihypertensive Activity

    • Low evidence
    • Rigorous Journal

  • The effect of kefir produced from natural kefir grains on the intestinal microbial populations and antioxidant capacities of Balb/c mice.

    • 2019-01
    • Food Research International 115
    • • F. Erdoğan
      • S. Ozarslan
      • Z. Guzel‐Seydim
      • Tuğba Kök Taş

    • PubMed: 30599959
    • DOI: 10.1016/j.foodres.2018.10.080

    7 Insights on

    • Reduced Myeloperoxidase Levels
    • Improved Antioxidant Capacity
    • Improved Total Antioxidant Status
    • Reduced Mold Presence
    • Reduced MPO Levels
    • Improved Intestinal Microbiota
    • Increased Lactic Acid Bacteria Levels

    • Low evidence

  • Effects of daily consumption of psyllium, oat bran and polyGlycopleX on obesity-related disease risk factors: A critical review.

    • 2019-01
    • Review
    • Nutrition (Burbank, Los Angeles County, Calif.) 57
    • • Monica Jane
      • Jenny McKay
      • Sebely Pal

    • PubMed: 30153584
    • DOI: 10.1016/j.nut.2018.05.036

    4 Insights on

    • Increased Satiety
    • Reduced Blood Cholesterol
    • Reduced LDL Cholesterol
    • Improved Glycemic Response

    • Low evidence

  • Effects of dietary Enterococcus faecium NCIMB 11181 supplementation on growth performance and cellular and humoral immune responses in broiler chickens

    • 2019-01
    • RCT · n = 360
    • Poultry Science 98(1)
    • • Yuanyuan Wu
      • W. Zhen
      • Y. Geng
      • Zhong Wang
      • Yuming Guo

    • PubMed: 30137622
    • DOI: 10.3382/ps/pey368

    5 Insights on

    • Elevated BSA Antibody Levels
    • Increased Serum IgG2 Levels
    • Improved Peripheral Blood Lymphocyte Proliferation
    • Increased Serum Lysozyme Activity
    • Improved Skin Responses

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Lactobacillus plantarum YS2 (yak yogurt Lactobacillus) exhibited an activity to attenuate activated carbon-induced constipation in male Kunming mice.

    • 2019-01
    • Clinical Trial
    • Journal of Dairy Science 102(1)
    • • Xin Zhao
      • Y. Qian
      • Guijie Li
      • Ruokun Yi
      • Kun-Young Park
      • Jia-Le Song

    • PubMed: 30527985
    • DOI: 10.3168/jds.2018-15206

    10 Insights on

    • Increased Vasoactive Intestinal Peptide Levels
    • Increased Serum Gastrin Levels
    • Elevated Serum Substance P Levels
    • Increased Serum Motilin Levels
    • Improved Gastrointestinal Peristalsis
    • Increased Expression of Glial Cell-Derived Neurotrophic Factor in the Colon
    • Increased Intestinal GLP-1 Levels
    • Improved Gastrointestinal Transit
    • Reduced Serum Somatostatin Levels
    • Elevated Serum Acetylcholine Levels

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Bifidobacterium may benefit the prevention of necrotizing enterocolitis in preterm infants: A systematic review and meta-analysis.

    • 2019-01
    • Meta-Analysis
    • International Journal of Surgery 61
    • • Xiu-li Zhu
      • Xiao-Gang Tang
      • Fan Qu
      • Yu Zheng
      • Wenhao Zhang
      • Yu-qiao Diao

    • PubMed: 30500473
    • DOI: 10.1016/j.ijsu.2018.11.026

    6 Insights on

    • Increased Late-Onset Sepsis Incidence
    • Reduced Colitis-Related Mortality
    • Reduced Mortality Risk
    • Reduced Incidence of Clinical Sepsis
    • Reduced Risk of Necrotizing Enterocolitis
    • Reduced Necrotising Enterocolitis

    • High evidence

  • Zinc Absorption from Micronutrient Powders Is Low in Bangladeshi Toddlers at Risk of Environmental Enteric Dysfunction and May Increase Dietary Zinc Requirements.

    • 2019-01
    • RCT · n = 74
    • The Journal of nutrition 149(1)
    • • Julie M Long
      • Prasenjit Mondal
      • Jamie E Westcott
      • Leland V Miller
      • M Munirul Islam
      • Mondar Ahmed
      • Mustafa Mahfuz
      • Tahmeed Ahmed
      • Nancy F Krebs

    • PubMed: 30624753
    • DOI: 10.1093/jn/nxy245

    2 Insights on

    • Increased Total Daily Absorbed Zinc Level
    • Met Estimated Physiologic Requirement for Zinc

    • High evidence

  • A dietary pattern rich in calcium, potassium, and protein is associated with tibia bone mineral content and strength in young adults entering initial military training.

    • 2019-01
    • RCT · n = 401
    • The American journal of clinical nutrition 109(1)
    • • Anna T Nakayama
      • Laura J Lutz
      • Adela Hruby
      • James P Karl
      • James P McClung
      • Erin Gaffney-Stomberg

    • PubMed: 30615068
    • DOI: 10.1093/ajcn/nqy199

    2 Insights on

    • Improved Bone Mineral Content
    • Improved Bone Strength

    • High evidence
    • Large Human Trial

  • Pilot Analysis of Early Lactobacillus rhamnosus GG for Infant Colic Prevention.

    • 2019-01
    • RCT · n = 184
    • Journal of pediatric gastroenterology and nutrition 68(1)
    • • Michael D Cabana
      • Michelle McKean
      • Amy L Beck
      • Valerie Flaherman

    • PubMed: 30052571
    • DOI: 10.1097/mpg.0000000000002113

    2 Insights on

    • Reduced Colic
    • Reduced Colic Symptoms

    • High evidence
    • Large Human Trial

  • The role of conserved non-aromatic residues in the Lactobacillus amylovorus α-amylase CBM26-starch interaction.

    • 2019-01
    • International journal of biological macromolecules 121
    • • Silvia Armenta
      • Zaira Sánchez-Cuapio
      • Maria Elena Munguia
      • Nancy O Pulido
      • Amelia Farrés
      • Karen Manoutcharian
      • Alejandra Hernandez-Santoyo
      • Silvia Moreno-Mendieta
      • Sergio Sánchez
      • Romina Rodríguez-Sanoja

    • PubMed: 30336243
    • DOI: 10.1016/j.ijbiomac.2018.10.061

    1 Insight on

    • Carbohydrate Binding Activity

    • Low evidence

  • Does L-Methylfolate Supplement Methylphenidate Pharmacotherapy in Attention-Deficit/Hyperactivity Disorder?: Evidence of Lack of Benefit From a Double-Blind, Placebo-Controlled, Randomized Clinical Trial.

    • 2019-01
    • RCT
    • Journal of clinical psychopharmacology 39(1)
    • • Craig Surman
      • Atilla Ceranoglu
      • Carrie Vaudreuil
      • Brittany Albright
      • Mai Uchida
      • Amy Yule
      • Andrea Spencer
      • Heidi Boland
      • Rebecca Grossman
      • Lauren Rhodewalt
      • Maura Fitzgerald
      • Joseph Biederman

    • PubMed: 30566416
    • DOI: 10.1097/jcp.0000000000000990

    8 Insights on

    • Improved Emotional Dysregulation
    • Improved Social Adjustment
    • Improved Cognitive Function
    • Improved Adaptive Functioning
    • Improved Delayed Memory
    • Reduced ADHD Symptoms
    • Improved Work Productivity
    • Reduced Methylphenidate Dosing Requirement

    • High evidence

  • Problem-Solving Exercise for Undergraduate Students Involving the Japanese Fermented Food Natto †

    • 2019-01
    • Journal of Microbiology & Biology Education 20(1)
    • • Yoko Yoshiyama
      • J. Shima
      • T. Fushiki

    • PubMed: 31160925
    • DOI: 10.1128/jmbe.v20i1.1614

    1 Insight on

    • Increased Protein Intake

    • Low evidence