July 2021 Supplement Research Papers

• July 1

  • Individual Participant Data Meta-Analysis Provides No Evidence of Intervention Response Variation in Individuals Supplementing With Beta-Alanine.

    • 2021-07-01
    • Meta-Analysis
    • International journal of sport nutrition and exercise metabolism 31(4)
    • • Gabriel Perri Esteves
      • Paul Swinton
      • Craig Sale
      • Ruth M James
      • Guilherme Giannini Artioli
      • Hamilton Roschel
      • Bruno Gualano
      • Bryan Saunders
      • Eimear Dolan

    • PubMed: 34098531
    • DOI: 10.1123/ijsnem.2021-0038

    2 Insights on

    • Improved Time to Exhaustion
    • Increased Carnosine Level

    • High evidence
• July 5

  • Effect of aromatherapy with Melissa essential oil on stress and hemodynamic parameters in acute coronary syndrome patients: A clinical trial in the emergency department.

    • 2021-07-05
    • RCT · n = 72
    • Complementary therapies in clinical practice 44
    • • Atefeh Veiskaramian
      • Mohammad Gholami
      • Sajad Yarahmadi
      • Peyman Amanolahi Baharvand
      • Mehdi Birjandi

    • PubMed: 34247027
    • DOI: 10.1016/j.ctcp.2021.101436

    3 Insights on

    • Reduced Stress Levels
    • Reduced Mean Arterial Pressure
    • Reduced Heart Rate

    • High evidence
• July 8

  • Lactobacillus plantarum HAC01 Supplementation Improves Glycemic Control in Prediabetic Subjects: A Randomized, Double-Blind, Placebo-Controlled Trial

    • 2021-07-08
    • RCT · n = 40
    • Nutrients 13(7)
    • • Mi-Ra Oh
      • Hui-Yeon Jang
      • Si-Yeon Lee
      • Su-Jin Jung
      • S. Chae
      • Seung-Ok Lee
      • Byung-Hyun Park

    • PubMed: 34371847
    • DOI: 10.3390/nu13072337

    10 Insights on

    • Improved Hemoglobin A1c Levels
    • Improved Glycemic Control
    • Reduced Blood HbA1c Levels
    • No Significant Adverse Events
    • Increased Blood Glucose Levels
    • Unchanged Insulin Sensitivity
    • Maintained Gut Microbiota Stability
    • Stable Fasting Plasma Glucose
    • Improved Postprandial Glucose Levels
    • Reduced Postprandial Glucose

    • High evidence

  • Updated Genome Sequence for the Probiotic Bacterium Bifidobacterium animalis subsp. lactis BB-12.

    • 2021-07-08
    • Microbiology resource announcements 10(27)
    • • Kristian Jensen
      • Kosai Al-Nakeeb
      • Anna Koza
      • Ahmad A Zeidan

    • PubMed: 34236222
    • DOI: 10.1128/mra.00078-21

    1 Insight on

    • Genome Sequencing / Genome Characterization

    • Low evidence
• July 9

  • Prophylactic effects of oral administration of Lactobacillus casei on house dust mite-induced asthma in mice.

    • 2021-07-09
    • Clinical Trial
    • Food & Function 11(10)
    • • Lingzhi Li
      • Zhifeng Fang
      • Yuan-Kun Lee
      • Jianxin Zhao
      • Hao Zhang
      • Wenwei Lu
      • Wei Chen

    • PubMed: 33047743
    • DOI: 10.1039/d0fo01363c

    14 Insights on

    • Reduced Pro-Inflammatory Cytokines
    • Increased Interleukin-10 Levels
    • Increased Secretory IgA Level
    • Reduced Total IgE Levels
    • Reduced Airway Inflammation
    • Decreased Granulocyte Count in Lungs
    • Reduced Chemokine Levels
    • Improved Gut Microbiota Richness
    • Reduced Granulocyte Levels
    • Reduced Airway Inflammation Score
    • Increased Secretory Immunoglobulin A
    • Reduced HDM-Specific IgG1 Levels
    • Enhanced Gut Microbiota Diversity
    • Improved Gut Microbial Richness

    • Low evidence
    • Animal Study
• July 15

  • Lactobacillus plantarum Reduces Low-Grade Inflammation and Glucose Levels in a Mouse Model of Chronic Stress and Diabetes

    • 2021-07-15
    • RCT
    • Infection and Immunity 89(8)
    • • H. S. Youn
      • Jong-Hwa Kim
      • Ji Soo Lee
      • Yeo Yeong Yoon
      • Seong Jun Choi
      • Joo Young Lee
      • Wonyong Kim
      • K. Hwang

    • PubMed: 34001561
    • DOI: 10.1128/IAI.00615-20

    8 Insights on

    • Reduced Pro-Inflammatory Cytokines
    • Improved Blood Glucose Levels
    • Reduced Inflammation Levels
    • Reduced Serum Glucose Levels
    • Reduced Subjective Stress Levels
    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Low-Grade Inflammation
    • Reduced Corticosterone Levels

    • Low evidence
    • Rigorous Journal
    • Animal Study
• July 16

  • Dietary Supplementation with Saccharomyces cerevisiae, Clostridium butyricum and Their Combination Ameliorate Rumen Fermentation and Growth Performance of Heat-Stressed Goats

    • 2021-07-16
    • RCT
    • Animals 11(7)
    • • Liyuan Cai
      • Jiangkun Yu
      • R. Hartanto
      • D. Qi

    • PubMed: 34359244
    • DOI: 10.3390/ani11072116

    1 Insight on

    • Improved Growth Performance

    • High evidence
    • Rigorous Journal
• July 19

  • Lactobacillus casei alleviated the abnormal increase of cholestasis-related liver indices during tuberculosis treatment: a post hoc analysis of randomized controlled trial.

    • 2021-07-19
    • RCT · n = 429
    • Molecular Nutrition & Food Research 65(16)
    • • Ke Xiong
      • Jing Cai
      • Peiying Liu
      • Jinyu Wang
      • Shanliang Zhao
      • Lei Xu
      • Yang Yang
      • Jiahong Liu
      • A. Ma

    • PubMed: 33864432
    • DOI: 10.1002/mnfr.202100108

    9 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Abnormal Cholestasis-Related Liver Indices
    • Reduced Plasma Lipopolysaccharide Levels
    • Improved Gut Permeability
    • Reduced Incidence of Cholestasis
    • Reduced Incidence of Hyperbilirubinemia
    • Reduced Alkaline Phosphatase Level
    • Reduced Incidence of Abnormal Increase in Alkaline Phosphatase
    • Reduced Abnormal Increase in Bilirubin

    • High evidence
    • Large Human Trial
    • Rigorous Journal

  • Human Systemic Immune Response to Ingestion of the Oral Probiotic Streptococcus salivarius BLIS K12

    • 2021-07-19
    • RCT
    • Probiotics and Antimicrobial Proteins 13(6)
    • • Gemma L. Laws
      • John D. F. Hale
      • Roslyn A. Kemp

    • PubMed: 34282568
    • DOI: 10.1007/s12602-021-09822-3

    8 Insights on

    • Increased Interleukin-10 Levels
    • Increased Regulatory T Cell Frequency
    • Increased IL-12 Levels
    • Elevated Interleukin-8 Levels
    • Increased IL-10 Concentration
    • Increased IL-8 Levels at 24 Hours
    • Increased Treg Frequency at 7 Days
    • Altered Systemic Immune Response

    • High evidence
• July 23

  • Effects of 60-Day Saccharomyces boulardii and Superoxide Dismutase Supplementation on Body Composition, Hunger Sensation, Pro/Antioxidant Ratio, Inflammation and Hormonal Lipo-Metabolic Biomarkers in Obese Adults: A Double-Blind, Placebo-Controlled Trial

    • 2021-07-23
    • RCT · n = 25
    • Nutrients 13(8)
    • • M. Rondanelli
      • N. Miraglia
      • P. Putignano
      • I. Castagliuolo
      • P. Brun
      • S. Dall'acqua
      • G. Peroni
      • M. Faliva
      • M. Naso
      • M. Nichetti
      • V. Infantino
      • S. Perna

    • PubMed: 34444671
    • DOI: 10.3390/nu13082512

    5 Insights on

    • Improved Insulin Sensitivity
    • Reduced Body Weight
    • Reduced Uric Acid Levels
    • Improved Vitamin D Levels
    • Reduced GLP-1 Levels

    • High evidence

  • Efficacy of Daily Supplementation of Milk Fortified With Vitamin D2 for Three Months in Healthy School Children: A Randomized Placebo Controlled Trial.

    • 2021-07-23
    • RCT · n = 119
    • Indian pediatrics 58(9)
    • • Raman Kumar Marwaha
      • Aashima Dabas
      • Seema Puri
      • Mani Kalaivani
      • Vineet Dabas
      • Sangeeta Yadav
      • Arjun Dang
      • R Pullakhandam
      • Sushil Gupta
      • Archana Narang

    • PubMed: 34302325
    • DOI: 10.1007/s13312-021-2300-9

    6 Insights on

    • Reduced Parathyroid Hormone Levels
    • Increased 25-hydroxyvitamin D Level
    • Reduced C-terminal Telopeptide Level
    • Reduced Procollagen Type 1 N-terminal Propeptide Level
    • Changed Urinary Calcium Creatinine Ratio
    • Achieved Sufficient Serum 25-Hydroxyvitamin D Level

    • High evidence
    • Large Human Trial
• July 25

  • One-Week High-Dose β-Alanine Loading Improves World Tour Cyclists' Time-Trial Performance.

    • 2021-07-25
    • RCT
    • Nutrients 13(8)
    • • Vicente Ávila-Gandía
      • Antonio Torregrosa-García
      • Silvia Pérez-Piñero
      • Raquel Ortolano
      • María Salud Abellán-Ruiz
      • F Javier López-Román

    • PubMed: 34444703
    • DOI: 10.3390/nu13082543

    13 Insights on

    • Reduced Faecal pH
    • Reduced Lactate Levels
    • Increased Lactate Levels
    • Improved Mean Power
    • Improved Work Capacity
    • Reduced Bicarbonate Level
    • Reduced Perceived Exertion
    • Improved Distance Traveled
    • Changed Walking Cadence
    • Increased Anion Gap
    • Changed Bicarbonate Level
    • Reduced Cadence
    • Reduced Anion Gap

    • High evidence
    • Rigorous Journal
• July 26

  • Effect of Berberine on Cardiovascular Disease Risk Factors: A Mechanistic Randomized Controlled Trial.

    • 2021-07-26
    • RCT · n = 84
    • Nutrients 13(8)
    • • Jie V Zhao
      • Wai-Fung Yeung
      • Yap-Hang Chan
      • Dana Vackova
      • June Y Y Leung
      • Dennis K M Ip
      • Jiaxi Zhao
      • Wai-Kwan Ho
      • Hung-Fat Tse
      • Catherine Mary Schooling

    • PubMed: 34444711
    • DOI: 10.3390/nu13082550

    9 Insights on

    • Reduced Body Mass Index
    • Reduced Waist-to-Height Ratio
    • Reduced Low-Density Lipoprotein Level
    • Reduced Blood Pressure
    • Reduced Triglyceride Levels
    • Reduced Blood Cholesterol
    • Increased Testosterone Level
    • Reduced High-Density Lipoprotein Cholesterol Level
    • Reduced Thromboxane A2 Level

    • High evidence
    • Rigorous Journal

  • Amelioration of 5-fluorouracil-induced intestinal mucositis by Streptococcus thermophilus ST4 in a mouse model

    • 2021-07-26
    • RCT · n = 15
    • PLOS ONE 16(7)
    • • S. Shen
      • Wei‐Jen Chen
      • Hui-Fang Chu
      • Shiuan-Huei Wu
      • Yu-Ru Wang
      • Tang-Long Shen

    • PubMed: 34310611
    • DOI: 10.1371/journal.pone.0253540

    9 Insights on

    • Reduced Diarrhea Incidence
    • Reduced Body Weight
    • Reduced Diarrhea Rate
    • Reduced Intestinal Inflammation
    • Increased Acetic Acid Levels in Feces
    • Maintained Intestinal Epithelial Homeostasis
    • Reduced Appetite Loss Incidence
    • Improved Appetite
    • Maintained Epithelium Structure

    • Low evidence
    • Rigorous Journal
    • Animal Study
• July 27

  • Rhizospheric Lactobacillus plantarum (Lactiplantibacillus plantarum) strains exhibit bile salt hydrolysis, hypocholestrolemic and probiotic capabilities in vitro

    • 2021-07-27
    • Scientific Reports 11(1)
    • • N. Singhal
      • N. S. Singh
      • S. Mohanty
      • Manish Kumar
      • J. S. Virdi

    • PubMed: 34315963
    • DOI: 10.1038/s41598-021-94776-3

    4 Insights on

    • Reduced Serum Cholesterol Levels
    • Improved Gut Health
    • Enhanced Gut Health
    • Increased Survival in Acidic Environment

    • Low evidence
    • Rigorous Journal

  • Interstrain Variability of Human Vaginal Lactobacillus crispatus for Metabolism of Biogenic Amines and Antimicrobial Activity against Urogenital Pathogens

    • 2021-07-27
    • Molecules 26(15)
    • • Scarlett Puebla-Barragan
      • Emiley Watson
      • C. van der Veer
      • John Antonio Chmiel
      • Charles Carr
      • J. Burton
      • M. Sumarah
      • R. Kort
      • G. Reid

    • PubMed: 34361691
    • DOI: 10.3390/molecules26154538

    1 Insight on

    • Increased Production of Biogenic Amines

    • Low evidence
• July 28

  • Bifidobacterium bifidum Enhances the Intestinal Epithelial Tight Junction Barrier and Protects against Intestinal Inflammation by Targeting the Toll-like Receptor-2 Pathway in an NF-κB-Independent Manner

    • 2021-07-28
    • International Journal of Molecular Sciences 22(15)
    • • R. Al-Sadi
      • Viszwapriya Dharmaprakash
      • P. Nighot
      • Shuhong Guo
      • M. Nighot
      • Toan Do
      • T. Ma

    • PubMed: 34360835
    • DOI: 10.3390/ijms22158070

    2 Insights on

    • Reduced Intestinal Inflammation
    • Enhanced Intestinal Barrier Function

    • Low evidence

  • Saccharomyces boulardii Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice by Regulating NF-κB and Nrf2 Signaling Pathways

    • 2021-07-28
    • Clinical Trial
    • Oxidative Medicine and Cellular Longevity 2021
    • • Hui Gao
      • Yinzheng Li
      • Jie Sun
      • Huzi Xu
      • Meng Wang
      • Xuezhi Zuo
      • Q. Fu
      • Yanchao Guo
      • Zhenyan Chen
      • Piwei Zhang
      • Xudong Li
      • N. Wang
      • T. Ye
      • Ying Yao

    • PubMed: 34367460
    • DOI: 10.1155/2021/1622375

    3 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Inflammation
    • Reduced Colonic Oxidative Damage

    • Low evidence
    • Rigorous Journal
    • Animal Study
• July 29

  • Cell-Free Lactobacillus casei 21L10 Modulates Nitric Oxide Release and Cell Proliferation/Cell Death in Lipopolysaccharide-Challenged HT-29 Cells

    • 2021-07-29
    • Inflammation 44(6)
    • • D. Čížková
      • M. Cizek
      • M. Maloveská
      • M. Kmeťová
      • V. Kmeť
      • D. Bujňáková

    • PubMed: 34327573
    • DOI: 10.1007/s10753-021-01512-0

    2 Insights on

    • Reduced Nitric Oxide Production
    • Increased Cell Death

    • Low evidence
    • Rigorous Journal
• July 30

  • Genome-scale insights into the metabolic versatility of Limosilactobacillus reuteri

    • 2021-07-30
    • BMC Biotechnology 21(1)
    • • Hao Luo
      • Peishun Li
      • Hao Wang
      • S. Roos
      • B. Ji
      • Jens Nielsen

    • PubMed: 34330235
    • DOI: 10.1186/s12896-021-00702-w

    2 Insights on

    • Prevented Bone Loss
    • Enhanced Regulatory Immune System Development

    • Low evidence
• July 31

  • Effect of Rosa damascena on improvement of adults' sleep quality: a systematic review and meta-analysis of randomized controlled trials.

    • 2021-07-31
    • Meta-Analysis
    • Sleep medicine 87
    • • Mohammad Sadegh Ghorbani Rami
      • Morteza Nasiri
      • Mohammad Sadegh Aghili Nasab
      • Zohre Jafari
      • Mahya Torkaman
      • Shahoo Feizi
      • Behnam Farahmandnia
      • Masoomeh Asadi

    • PubMed: 34508987
    • DOI: 10.1016/j.sleep.2021.07.017

    1 Insight on

    • Improved Sleep Quality

    • High evidence

  • Effects of Acute Beta-Alanine Ingestion and Immersion-Plus-Exercise on Connectedness to Nature and Perceived Pain.

    • 2021-07-31
    • RCT
    • International journal of environmental research and public health 18(15)
    • • R W Salatto
      • Graham R McGinnis
      • Dustin W Davis
      • Bryson Carrier
      • Jacob W Manning
      • Mark DeBeliso
      • James W Navalta

    • PubMed: 34360425
    • DOI: 10.3390/ijerph18158134

    4 Insights on

    • Reduced Rating of Perceived Exertion
    • Reduced Heart Rate
    • Increased Perceived Pain
    • Improved Love and Care of Nature

    • High evidence
• Undated – 6 supplement studies

  • Bifidobacteria-mediated immune system imprinting early in life

    • 2021-07
    • Cell 184(15)
    • • B. Henrick
      • L. Rodriguez
      • T. Lakshmikanth
      • Christian Pou
      • E. Henckel
      • E. Henckel
      • E. Henckel
      • Axel Olin
      • Jun Wang
      • J. Mikeš
      • Ziyang Tan
      • Yang Chen
      • Amy M. Ehrlich
      • A. Bernhardsson
      • C. Mugabo
      • Ylva Ambrosiani
      • Anna Gustafsson
      • Anna Gustafsson
      • Stephanie Chew
      • H. Brown
      • Johann Prambs
      • Kajsa Bohlin
      • Kajsa Bohlin
      • Ryan D. Mitchell
      • M. Underwood
      • J. Smilowitz
      • J. German
      • S. Frese
      • P. Brodin
      • P. Brodin

    • PubMed: 34143954
    • DOI: 10.1016/j.cell.2021.05.030

    3 Insights on

    • Reduced Inflammation Levels
    • Reduced Inflammation
    • Improved Immune Regulation

    • High evidence
    • Highly Cited

  • Supplementation with Bifidobacterium breve BR03 and B632 strains improved insulin sensitivity in children and adolescents with obesity in a cross-over, randomized double-blind placebo-controlled trial.

    • 2021-07
    • RCT · n = 101
    • Clinical Nutrition 40(7)
    • • Arianna Solito
      • Nicole Bozzi Cionci
      • M. Calgaro
      • M. Caputo
      • L. Vannini
      • Iderina Hasballa
      • Francesca Archero
      • E. Giglione
      • R. Ricotti
      • G. Walker
      • A. Petri
      • Emanuela Agosti
      • G. Bellomo
      • G. Aimaretti
      • G. Bona
      • S. Bellone
      • A. Amoruso
      • M. Pane
      • D. Di Gioia
      • N. Vitulo
      • F. Prodam

    • PubMed: 34229263
    • DOI: 10.1016/j.clnu.2021.06.002

    6 Insights on

    • Improved Insulin Sensitivity
    • Reduced Body Weight
    • Improved Metabolic Parameters
    • Reduced Escherichia coli Counts
    • Improved Glucose Response
    • Maintained Fecal Short Chain Fatty Acid Levels

    • High evidence

  • Meta-analysis of effects of inoculation with Lactobacillus buchneri, with or without other bacteria, on silage fermentation, aerobic stability, and performance of dairy cows.

    • 2021-07
    • Meta-Analysis
    • Journal of Dairy Science 104(7)
    • • K. Arriola
      • A. Oliveira
      • Yun Jiang
      • Donghyeon Kim
      • H. M. Silva
      • Sam-Churl Kim
      • F. Amaro
      • I. Ogunade
      • H. Sultana
      • A. P. Pech Cervantes
      • L. Ferraretto
      • D. Vyas
      • A. Adesogan

    • PubMed: 33814134
    • DOI: 10.3168/jds.2020-19647

    6 Insights on

    • Reduced Candida Counts
    • Increased Fecal Propionic Acid Levels
    • Increased Fecal Acetate Concentration
    • Increased 1,2-Propanediol Concentration
    • Improved Aerobic Stability
    • Reduced Lactate Concentration

    • High evidence
    • Rigorous Journal

  • Bacillus amyloliquefaciens B10 can alleviate aflatoxin B1-induced kidney oxidative stress and apoptosis in mice.

    • 2021-07
    • RCT · n = 56
    • Ecotoxicology and Environmental Safety 218
    • • Yeqi Zhao
      • Tiancheng Wang
      • Peng Li
      • Jia Chen
      • E. Nepovimova
      • M. Long
      • Wenda Wu
      • K. Kuča

    • PubMed: 33933810
    • DOI: 10.1016/j.ecoenv.2021.112286

    3 Insights on

    • Reduced Kidney Oxidative Stress
    • Reduced Kidney Cell Apoptosis
    • Reduced Kidney Pathological Changes

    • Low evidence
    • Animal Study

  • Prebiotics and alternative poultry production.

    • 2021-07
    • Review
    • Poultry science 100(7)
    • • Steven C Ricke

    • PubMed: 34102481
    • DOI: 10.1016/j.psj.2021.101174

    3 Insights on

    • Improved Gut Microbiota
    • Improved Gastrointestinal Health
    • Reduced Foodborne Pathogens

    • Low evidence
    • Animal Study

  • Safety assessment of Streptococcus salivarius DB-B5 as a probiotic candidate for oral health.

    • 2021-07
    • Food and Chemical Toxicology 153
    • • Xuyao Li
      • F. R. Fields
      • M. Ho
      • Allyson Marshall-Hudson
      • R. Gross
      • Michael E Casser
      • M. Naito

    • PubMed: 34004226
    • DOI: 10.1016/j.fct.2021.112277

    1 Insight on

    • Improved Safe Consumption Practices

    • Low evidence