October 2021 Supplement Research Papers

• October 1

  • Fermentation Supernatants of Pleurotus eryngii Mushroom Ameliorate Intestinal Epithelial Barrier Dysfunction in Lipopolysaccharide-Induced Caco-2 Cells via Upregulation of Tight Junctions.

    • 2021-10-01
    • Microorganisms 9(10)
    • • Georgia Saxami
      • Evangelia N Kerezoudi
      • Evdokia K Mitsou
      • Georgios Koutrotsios
      • Georgios I Zervakis
      • Vasiliki Pletsa
      • Adamantini Kyriacou

    • PubMed: 34683391
    • DOI: 10.3390/microorganisms9102071

    1 Insight on

    • Improved Intestinal Barrier Function

    • Low evidence

  • Pathogen-Specific Effects of Probiotics in Children with Acute Gastroenteritis Seeking Emergency Care: A Randomized Trial.

    • 2021-10-01
    • RCT · n = 1,565
    • Clinical Infectious Diseases 75(1)
    • • S. Freedman
      • Y. Finkelstein
      • X. Pang
      • L. Chui
      • P. Tarr
      • J. VanBuren
      • Cody S. Olsen
      • Bonita E. Lee
      • R. Sapién
      • Karen A. O’Connell
      • A. Levine
      • N. Poonai
      • C. Roskind
      • S. Schuh
      • A. Rogers
      • S. Bhatt
      • S. Gouin
      • P. Mahajan
      • C. Vance
      • K. Hurley
      • E. Powell
      • K. Farion
      • D. Schnadower

    • PubMed: 34596225
    • DOI: 10.1093/cid/ciab876

    1 Insight on

    • Reduced Diarrhea Episodes

    • High evidence
    • Large Human Trial

  • Effect of Enterococcus faecium as a Water and/or Feed Additive on the Gut Microbiota, Hematologic and Immunological Parameters, and Resistance Against Francisellosis and Streptococcosis in Nile Tilapia (Oreochromis niloticus)

    • 2021-10-01
    • Frontiers in Microbiology 12
    • • S. A. Suphoronski
      • Felipe Pinheiro De Souza
      • R. T. Chideroli
      • Leonardo Mantovani Favero
      • N. A. Ferrari
      • H. M. Ziemniczak
      • D. Gonçalves
      • Nelson Mauricio Lopera Barrero
      • U. P. Pereira

    • PubMed: 34659177
    • DOI: 10.3389/fmicb.2021.743957

    4 Insights on

    • Increased Body Weight
    • Enhanced Immunity
    • Increased Thrombocyte Count
    • Reduced Mortality from Streptococcal Infection

    • Low evidence

  • The effects of feeding benzoic acid and/or live active yeast (Saccharomyces cerevisiae) on beef cattle performance, feeding behavior, and carcass characteristics.

    • 2021-10-01
    • Clinical Trial
    • Translational animal science 5(4)
    • • Melissa S Williams
      • Ira Brent Mandell
      • Benjamin M Bohrer
      • Katharine M Wood

    • PubMed: 34877478
    • DOI: 10.1093/tas/txab143

    1 Insight on

    • Increased Aspartate Aminotransferase Concentration

    • Moderate evidence
• October 2

  • Effect of Bacillus coagulans Unique IS2 with Lactulose on Functional Constipation in Adults: a Double-Blind Placebo Controlled Study

    • 2021-10-02
    • RCT · n = 50
    • Probiotics and Antimicrobial Proteins 15(2)
    • • R. Venkataraman
      • R. Shenoy
      • J. Ahire
      • J. Neelamraju
      • R. Madempudi

    • PubMed: 34599466
    • DOI: 10.1007/s12602-021-09855-8

    5 Insights on

    • Improved Stool Consistency
    • Reduced Abdominal Pain
    • Increased Stool Frequency
    • Reduced Sense of Incomplete Evacuation
    • Reduced Painful Defecation

    • High evidence
• October 4

  • Probiotic Lactiplantibacillus plantarum N‐1 could prevent ethylene glycol‐induced kidney stones by regulating gut microbiota and enhancing intestinal barrier function

    • 2021-10-04
    • Clinical Trial
    • The FASEB Journal 35(11)
    • • Zhitao Wei
      • Yanan Cui
      • Lei Tian
      • Yu Liu
      • Yang Yu
      • X. Jin
      • Hong Li
      • Kun-jie Wang
      • Qun Sun

    • PubMed: 34606628
    • DOI: 10.1096/fj.202100887RR

    9 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Intestinal Inflammation
    • Increased Short-Chain Fatty Acid Production
    • Increased SCFA-Producing Bacteria
    • Enhanced SCFA Production
    • Prevention of Kidney Stones
    • Reduced Kidney Stone Formation
    • Reduced Renal Crystalline Deposits
    • Increased Abundance of Beneficial SCFAs-Producing Bacteria

    • Low evidence
    • Rigorous Journal
    • Animal Study
• October 6

  • Lactiplantibacillus plantarum–Nomad and Ideal Probiotic

    • 2021-10-06
    • Frontiers in Microbiology 12
    • • Mario Fidanza
      • P. Panigrahi
      • T. Kollmann

    • PubMed: 34690957
    • DOI: 10.3389/fmicb.2021.712236

    1 Insight on

    • Improved Human Health

    • Low evidence

  • Effect of drops containing Lactobacillus reuteri (DSM 17938 and ATCC PTA 5289) on plaque acidogenicity and other caries-related variables in orthodontic patients

    • 2021-10-06
    • RCT · n = 28
    • BMC Microbiology 21(1)
    • • Sahal Alforaidi
      • A. Bresin
      • Naif A. Almosa
      • Anna Lehrkinder
      • P. Lingström

    • PubMed: 34615458
    • DOI: 10.1186/s12866-021-02310-2

    1 Insight on

    • Increased Plaque pH Levels

    • High evidence
    • Rigorous Journal
• October 8

  • Lactobacillus rhamnosus Probio-M9 Improves the Quality of Life in Stressed Adults by Gut Microbiota

    • 2021-10-08
    • RCT · n = 12
    • Foods 10(10)
    • • Yan Zheng
      • Zhongjie Yu
      • Wenyi Zhang
      • T. Sun

    • PubMed: 34681433
    • DOI: 10.3390/foods10102384

    5 Insights on

    • Improved Gut Microbiota Diversity
    • Improved Quality of Life
    • Increased Beneficial Gut Microbiota
    • Improved Abundance of Beneficial Bacteria
    • Improved Mental Health

    • High evidence
    • Rigorous Journal
• October 10

  • Microbiome Modulation as a Therapeutic Approach in Chronic Skin Diseases.

    • 2021-10-10
    • Review
    • Biomedicines 9(10)
    • • Karina Polak
      • Antal Jobbágy
      • Tomasz Muszyński
      • Kamila Wojciechowska
      • Aleksandra Frątczak
      • András Bánvölgyi
      • Beata Bergler-Czop
      • Norbert Kiss

    • PubMed: 34680552
    • DOI: 10.3390/biomedicines9101436

    1 Insight on

    • Improved Skin Symptoms

    • Low evidence
• October 11

  • Lactiplantibacillus plantarum 299v (LP299V®): three decades of research.

    • 2021-10-11
    • Review
    • Beneficial Microbes 12(5)
    • • E. Nordström
      • C. Teixeira
      • C. Montelius
      • B. Jeppsson
      • N. Larsson

    • PubMed: 34365915
    • DOI: 10.3920/BM2020.0191

    4 Insights on

    • Reduced Flatulence
    • Improved Iron Absorption
    • Reduced Abdominal Pain
    • Improved Iron Levels

    • Low evidence

  • Alleviation of low-fiber diet-induced constipation by probiotic Bifidobacterium bifidum G9-1 is based on correction of gut microbiota dysbiosis

    • 2021-10-11
    • Clinical Trial
    • Bioscience of Microbiota, Food and Health 38(2)
    • • Yutaka Makizaki
      • Ayako Maeda
      • Yosuke Oikawa
      • Saya Tamura
      • Yoshiki Tanaka
      • Shunji Nakajima
      • H. Yamamura

    • PubMed: 31106107
    • DOI: 10.12938/bmfh.18-020

    2 Insights on

    • Improved Gut Microbiota
    • Improved Constipation Symptoms

    • Low evidence
    • Rigorous Journal
    • Animal Study
• October 12

  • Effects of a high-γ-polyglutamic acid-containing natto diet on liver lipids and cecal microbiota of adult female mice

    • 2021-10-12
    • Clinical Trial
    • Bioscience of Microbiota, Food and Health 40(4)
    • • M. Tamura
      • J. Watanabe
      • S. Hori
      • Atsuko Inose
      • Yuji Kubo
      • Tomotsugu Noguchi
      • Takanobu Nishikawa
      • Masaya Ikezawa
      • R. Araki
      • M. Kobori

    • PubMed: 34631329
    • DOI: 10.12938/bmfh.2020-061

    2 Insights on

    • Reduced Relative Abundance of Coriobacteriaceae
    • Prevention of Nonalcoholic Fatty Liver Disease

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Project Earthrise: Proceedings of the Ninth Annual Conference of inVIVO Planetary Health.

    • 2021-10-12
    • Review
    • International journal of environmental research and public health 18(20)
    • • Susan L Prescott
      • Ganesa Wegienka
      • Remco Kort
      • David H Nelson
      • Sabine Gabrysch
      • Trevor Hancock
      • Anita Kozyrskyj
      • Christopher A Lowry
      • Nicole Redvers
      • Blake Poland
      • Jake Robinson
      • Jean-Claude Moubarac
      • Sara Warber
      • Janet Jansson
      • Aki Sinkkonen
      • John Penders
      • Susan Erdman
      • Ralph Nanan
      • Matilda van den Bosch
      • Kirk Schneider
      • Nicholas J Schroeck
      • Tanja Sobko
      • Jamie Harvie
      • George A Kaplan
      • Rob Moodie
      • Laura Lengnick
      • Isaac Prilleltensky
      • Yuria Celidwen
      • Susan H Berman
      • Alan C Logan
      • Brian Berman

    • PubMed: 34682400
    • DOI: 10.3390/ijerph182010654

    3 Insights on

    • Improved Immune Function
    • Improved Gastrointestinal Symptoms
    • No Human Health Outcome Reported

    • Low evidence
• October 15

  • Bacteremia after Bacillus clausii administration for the treatment of acute diarrhea: A case report

    • 2021-10-15
    • Case Report · n = 1
    • Biomédica 41(Sp. 2)
    • • J. P. García
      • J. Hoyos
      • J. Alzate
      • Edilberto Cristancho

    • PubMed: 34669274
    • DOI: 10.7705/biomedica.5662

    1 Insight on

    • Reduced Bacteremia Incidence

    • Low evidence
• October 16

  • The role of the tumor microbe microenvironment in the tumor immune microenvironment: bystander, activator, or inhibitor?

    • 2021-10-16
    • Review
    • Journal of experimental & clinical cancer research : CR 40(1)
    • • Jiayao Ma
      • Lingjuan Huang
      • Die Hu
      • Shan Zeng
      • Ying Han
      • Hong Shen

    • PubMed: 34656142
    • DOI: 10.1186/s13046-021-02128-w

    1 Insight on

    • Unclear / Not Reported in Provided Abstract

    • Low evidence

  • Supplementation with Lactiplantibacillus plantarum IMC 510 Modifies Microbiota Composition and Prevents Body Weight Gain Induced by Cafeteria Diet in Rats

    • 2021-10-16
    • Clinical Trial
    • International Journal of Molecular Sciences 22(20)
    • • M. V. Micioni Di Bonaventura
      • M. Coman
      • D. Tomassoni
      • E. Micioni Di Bonaventura
      • L. Botticelli
      • M. G. Gabrielli
      • G. Rossolini
      • V. di Pilato
      • C. Cecchini
      • A. Amedei
      • S. Silvi
      • M. Verdenelli
      • C. Cifani

    • PubMed: 34681831
    • DOI: 10.3390/ijms222011171

    11 Insights on

    • Reduced Body Mass Index
    • Reduced Low-Density Lipoprotein Level
    • Reduced Body Weight
    • Reduced LDL Cholesterol
    • Reduced Hepatic Fat Accumulation
    • Reduced Adipocyte Size
    • Improved Serum Glycemia
    • Reduced Food Intake
    • Improved Blood Glucose Control
    • Restored Microbial Balance
    • Improved Glycemia

    • Low evidence
    • Animal Study
• October 17

  • Effects of Probiotics and Synbiotics on Weight Loss in Subjects with Overweight or Obesity: A Systematic Review.

    • 2021-10-17
    • Systematic Review
    • Nutrients 13(10)
    • • Valentina Álvarez-Arraño
      • Sandra Martín-Peláez

    • PubMed: 34684633
    • DOI: 10.3390/nu13103627

    1 Insight on

    • Reduced Body Weight

    • High evidence
    • Rigorous Journal
• October 21

  • Protective Effects of Bacillus amyloliquefaciens 40 Against Clostridium perfringens Infection in Mice

    • 2021-10-21
    • RCT · n = 24
    • Frontiers in Nutrition 8
    • • Zipeng Jiang
      • Wentao Li
      • W. Su
      • Chaoyue Wen
      • Tao Gong
      • Yu Zhang
      • Yizhen Wang
      • M. Jin
      • Zeqing Lu

    • PubMed: 34746206
    • DOI: 10.3389/fnut.2021.733591

    4 Insights on

    • Reduced Inflammatory Response
    • Reduced Intestinal Damage
    • Restored Intestinal Microbiota Balance
    • Influence on Metabolic Pathways

    • Low evidence
    • Animal Study

  • Alterations in Faecal Microbiota and Elevated Levels of Intestinal IgA Following Oral Administration of Lacticaseibacillus casei in mice

    • 2021-10-21
    • Clinical Trial
    • Probiotics and Antimicrobial Proteins 15(3)
    • • Georgios Aindelis
      • P. Ypsilantis
      • K. Chlichlia

    • PubMed: 34676502
    • DOI: 10.1007/s12602-021-09864-7

    1 Insight on

    • Increased Intestinal IgA Levels

    • Low evidence
    • Animal Study
• October 22

  • A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase.

    • 2021-10-22
    • Nature communications 12(1)
    • • Jessie MacAlpine
      • Martin Daniel-Ivad
      • Zhongle Liu
      • Junko Yano
      • Nicole M Revie
      • Robert T Todd
      • Peter J Stogios
      • Hiram Sanchez
      • Teresa R O'Meara
      • Thomas A Tompkins
      • Alexei Savchenko
      • Anna Selmecki
      • Amanda O Veri
      • David R Andes
      • Paul L Fidel
      • Nicole Robbins
      • Justin Nodwell
      • Luke Whitesell
      • Leah E Cowen

    • PubMed: 34686660
    • DOI: 10.1038/s41467-021-26390-w

    1 Insight on

    • Reduced Candida albicans Filamentation

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Effect of Fermentation Parameters on Natto and Its Thrombolytic Property

    • 2021-10-22
    • Foods 10(11)
    • • Yun Yang
      • Guangqun Lan
      • X. Tian
      • Laping He
      • Cuiqin Li
      • Xuefeng Zeng
      • Xiao Wang

    • PubMed: 34828828
    • DOI: 10.3390/foods10112547

    1 Insight on

    • Improved Thrombolytic Property

    • Low evidence
    • Rigorous Journal
• October 24

  • A Comparative Antibacterial, Antioxidant, and Antineoplastic Potential of Rauwolfia serpentina (L.) Leaf Extract with Its Biologically Synthesized Gold Nanoparticles (R-AuNPs).

    • 2021-10-24
    • Plants (Basel, Switzerland) 10(11)
    • • Mohammad Y Alshahrani
      • Mohammad Y Alshahrani
      • Zeeshan Rafi
      • Nadiyah M Alabdallah
      • Ambreen Shoaib
      • Irfan Ahmad
      • Mohammed Asiri
      • Gaffar Sarwar Zaman
      • Shadma Wahab
      • Mohd Saeed
      • Salman Khan

    • PubMed: 34834641
    • DOI: 10.3390/plants10112278

    3 Insights on

    • Increased Antioxidant Activity
    • Reduced Bacterial Load
    • Reduced Cancer Activity

    • Low evidence
• October 26

  • Enterococcus spp.: Is It a Bad Choice for a Good Use-A Conundrum to Solve?

    • 2021-10-26
    • Review
    • Microorganisms 9(11)
    • • Mounir Ferchichi
      • Khaled Sebei
      • Amine Mohamed Boukerb
      • Najoua Karray-Bouraoui
      • Sylvie Chevalier
      • Marc G J Feuilloley
      • Nathalie Connil
      • Mohamed Zommiti

    • PubMed: 34835352
    • DOI: 10.3390/microorganisms9112222

    1 Insight on

    • Improved Gastrointestinal Symptoms

    • Low evidence
• October 27

  • The Preventive Effect of Lactobacillus plantarum ZS62 on DSS-Induced IBD by Regulating Oxidative Stress and the Immune Response

    • 2021-10-27
    • Clinical Trial
    • Oxidative Medicine and Cellular Longevity 2021
    • • Yanni Pan
      • Yu Ning
      • Jing Hu
      • Zhiying Wang
      • Xiufeng Chen
      • Xin Zhao

    • PubMed: 34745426
    • DOI: 10.1155/2021/9416794

    6 Insights on

    • Reduced Pro-Inflammatory Cytokines
    • Increased Anti-inflammatory Cytokines
    • Reduced Colonic Oxidative Damage
    • Reduced Colonic Atrophy
    • Reduced Oxidative Stress Markers
    • Increased Serum Antioxidant Levels

    • Low evidence
    • Rigorous Journal
    • Animal Study
• October 29

  • A Pilot Study of the Effect of Lactobacillus casei Obtained from Long-Lived Elderly on Blood Biochemical, Oxidative, and Inflammatory Markers, and on Gut Microbiota in Young Volunteers

    • 2021-10-29
    • RCT · n = 20
    • Nutrients 13(11)
    • • Lijun Mei
      • Wenlong Zheng
      • Zheng-Tao Zhao
      • N. Meng
      • Qin-Ren Zhang
      • Wenyang Zhu
      • Rui-Ding Li
      • Xiao-Lin Liang
      • Quanyang Li

    • PubMed: 34836153
    • DOI: 10.3390/nu13113891

    20 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Hepatic Oxidative Stress
    • Increased Interleukin-10 Levels
    • Elevated Antioxidant Levels
    • Improved Overall Health Status
    • Increased Superoxide Dismutase Activity
    • Reduced TNF-α Levels
    • Reduced Serum Malondialdehyde Levels
    • Improved Inflammatory Response
    • Improved Antioxidant Capacity
    • Improved Gut Microbiome Composition
    • Regulated Inflammation
    • Elevated Interleukin-10 Levels
    • Increased Anti-Inflammatory Levels
    • Improved Antioxidant Levels
    • Increased Bifidobacterium Levels
    • Improved Microbiota Profile
    • Improved Inflammatory Biomarkers
    • Improved Total Antioxidant Capacity
    • Improved Health Status Score

    • High evidence
• Undated – 6 supplement studies

  • Probiotic lactobacilli in formulas and hygiene products for the health of the urogenital tract.

    • 2021-10
    • Review
    • Pharmacology research & perspectives 9(5)
    • • María Elena Fátima Nader-Macías
      • Priscilla Romina De Gregorio
      • Jessica Alejandra Silva

    • PubMed: 34609059
    • DOI: 10.1002/prp2.787

    4 Insights on

    • Improved Gut Microbiota Balance
    • Reduced Urogenital Infections
    • Improved Urogenital Tract Health
    • Restored Urogenital Tract Microbiome

    • Low evidence

  • Probiotic, Lactobacillus pentosus BD6 boost the growth and health status of white shrimp, Litopenaeus vannamei via oral administration.

    • 2021-10
    • Fish & Shellfish Immunology 117
    • • Shieh-Tsung Chiu
      • T. Chu
      • Tohap Simangunsong
      • Rolissa Ballantyne
      • Chiu-Shia Chiu
      • Chun‐Hung Liu

    • PubMed: 34343542
    • DOI: 10.1016/j.fsi.2021.07.024

    4 Insights on

    • Improved Antibacterial Activity
    • Improved Growth Performance
    • Enhanced Disease Resistance
    • Enhanced Immunity

    • Low evidence

  • Lactobacillus rhamnosus postbiotic-induced immunomodulation as safer alternative to the use of live bacteria.

    • 2021-10
    • Cytokine 146
    • • S. Salva
      • I. Tiscornia
      • Florencia Gutiérrez
      • S. Alvarez
      • M. Bollati-Fogolín

    • PubMed: 34252871
    • DOI: 10.1016/j.cyto.2021.155631

    5 Insights on

    • Improved Immune Response
    • Modulated Immune Response
    • Efficacy of Postbiotics in Immunocompromised Patients
    • Enhanced Immune Regulation
    • Increased Immune Response

    • Low evidence

  • Lactobacillus amylovorus derived lipase-mediated silver derivatization over poly(ε-caprolactone) towards antimicrobial coatings.

    • 2021-10
    • Enzyme and microbial technology 150
    • • Pranay Amruth Maroju
      • Pranathi Tata
      • Aniket Balapure
      • Jayati Ray Dutta
      • Ramakrishnan Ganesan

    • PubMed: 34489041
    • DOI: 10.1016/j.enzmictec.2021.109888

    4 Insights on

    • Improved Antimicrobial Ability
    • Improved Cell Viability
    • Improved Antimicrobial Surface Coating Performance
    • Improved Cell Compatibility

    • Low evidence
    • Animal Study

  • Inorganic polyphosphate from the immunobiotic Lactobacillus rhamnosus CRL1505 prevents inflammatory response in the respiratory tract

    • 2021-10
    • Clinical Trial
    • Saudi Journal of Biological Sciences 28(10)
    • • M. A. Correa Deza
      • A. Rodríguez de Olmos
      • N. Suárez
      • G. Font de Valdez
      • S. Salva
      • C. L. Gerez

    • PubMed: 34588880
    • DOI: 10.1016/j.sjbs.2021.06.010

    3 Insights on

    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Inflammation
    • Reduced Respiratory Inflammation Severity

    • Low evidence
    • Animal Study

  • Meta-analysis evaluating the impact of chili-pepper intake on all-cause and cardiovascular mortality: A systematic review.

    • 2021-10
    • Review
    • Annals of medicine and surgery (2012) 70
    • • Naser Yamani
      • Adeena Musheer
      • Priyanka Gosain
      • Saba Sarfraz
      • Humera Qamar
      • Muhammad Maaz Waseem
      • Muhammad Sameer Arshad
      • Talal Almas
      • Vincent Figueredo

    • PubMed: 34603712
    • DOI: 10.1016/j.amsu.2021.102774

    4 Insights on

    • Reduced All-Cause Mortality
    • Reduced Cardiovascular Mortality
    • Reduced Cancer Mortality
    • Reduced Cerebrovascular Mortality

    • Low evidence