March 2022 Supplement Research Papers

• March 1

  • Lactobacillus casei modulates inflammatory cytokines and metabolites during tuberculosis treatment: A post hoc randomized controlled trial.

    • 2022-03-01
    • RCT · n = 47
    • Asia Pacific journal of clinical nutrition 31(1)
    • • Lan Jiang
      • Jinyu Wang
      • Lei Xu
      • Jing Cai
      • Shanliang Zhao
      • Aiguo Ma

    • PubMed: 35357105
    • DOI: 10.6133/apjcn.202203_31(1).0008

    4 Insights on

    • Increased Interleukin-10 Levels
    • Reduced Interleukin-12 Level
    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Interleukin-6 Levels

    • High evidence

  • The influence of probiotics on gastrointestinal tract infections among children attending childcare: A systematic review and meta-analysis.

    • 2022-03-01
    • Meta-Analysis
    • Journal of applied microbiology 132(3)
    • • Hafiz H Ahmad
      • Blake Peck
      • Daniel Terry

    • PubMed: 34796583
    • DOI: 10.1111/jam.15374

    2 Insights on

    • Reduced Gastrointestinal Tract Infection Episode
    • Reduced Infection Duration

    • High evidence

  • Prophylactic Effect of Lactobacillus fermentum TKSN02 on Gastric Injury Induced by Hydrochloric Acid/Ethanol in Mice Through Its Antioxidant Capacity

    • 2022-03-01
    • Frontiers in Nutrition 9
    • • Tiantian Hu
      • Liang Zhou
      • Xiaoli Wang
      • Xianrong Zhou
      • Ruokun Yi
      • X. Long
      • Xin Zhao

    • PubMed: 35299759
    • DOI: 10.3389/fnut.2022.840566

    4 Insights on

    • Reduced Inflammatory Response
    • Elevated Antioxidant Levels
    • Modulated Gastrointestinal Hormone Levels
    • Reduced Gastric Injury

    • Low evidence
• March 2

  • Lactobacillus rhamnosus GR-1 Alleviates Escherichia coli-Induced Inflammation via NF-κB and MAPKs Signaling in Bovine Endometrial Epithelial Cells

    • 2022-03-02
    • Frontiers in Cellular and Infection Microbiology 12
    • • Jiawei Liu
      • Xiaowei Feng
      • Botong Li
      • Yan Sun
      • Tianxiong Jin
      • M. Feng
      • Yaodi Ni
      • Mingchao Liu

    • PubMed: 35310848
    • DOI: 10.3389/fcimb.2022.809674

    2 Insights on

    • Reduced Inflammatory Response
    • Reduced Inflammation

    • Low evidence
• March 3

  • Topical Probiotics: More Than a Skin Deep.

    • 2022-03-03
    • Review
    • Pharmaceutics 14(3)
    • • Mohammed Habeebuddin
      • Ranjith Kumar Karnati
      • Predeepkumar Narayanappa Shiroorkar
      • Sreeharsha Nagaraja
      • Syed Mohammed Basheeruddin Asdaq
      • Md Khalid Anwer
      • Santosh Fattepur

    • PubMed: 35335933
    • DOI: 10.3390/pharmaceutics14030557

    1 Insight on

    • Improved Skin Health

    • Low evidence

  • The effect of probiotics on gestational diabetes and its complications in pregnant mother and newborn: A systematic review and meta-analysis during 2010-2020.

    • 2022-03-03
    • Meta-Analysis · n = 4,865
    • Journal of clinical laboratory analysis 36(4)
    • • Marzie Mahdizade Ari
      • Samane Teymouri
      • Tayebeh Fazlalian
      • Parisa Asadollahi
      • Roghayeh Afifirad
      • Mohammad Sabaghan
      • Fateme Valizadeh
      • Roya Ghanavati
      • Atieh Darbandi

    • PubMed: 35243684
    • DOI: 10.1002/jcla.24326

    1 Insight on

    • Reduced Prevalence of Gestational Diabetes Mellitus

    • High evidence

  • Effects of Synbiotic Preparation Containing Lactobacillus gasseri BNR17 on Body Fat in Obese Dogs: A Pilot Study

    • 2022-03-03
    • Clinical Trial
    • Animals 12(5)
    • • Han-Joon Lee
      • Jae Hyoung Cho
      • W. Cho
      • Seong-Ho Gang
      • Seung‐Hwan Park
      • B. Jung
      • H. Kim
      • K. Song

    • PubMed: 35268209
    • DOI: 10.3390/ani12050642

    5 Insights on

    • Improved Body Condition Score
    • Reduced Body Fat
    • Reduced Subcutaneous Fat Mass
    • Reduced Body Weight
    • Increased Microbial Diversity

    • Low evidence
    • Rigorous Journal
    • Animal Study
• March 4

  • Intake of Soy, Soy Isoflavones and Soy Protein and Risk of Cancer Incidence and Mortality.

    • 2022-03-04
    • Systematic Review
    • Frontiers in nutrition 9
    • • Yahui Fan
      • Mingxu Wang
      • Zhaofang Li
      • Hong Jiang
      • Jia Shi
      • Xin Shi
      • Sijiao Liu
      • Jinping Zhao
      • Liyun Kong
      • Wei Zhang
      • Le Ma

    • PubMed: 35308286
    • DOI: 10.3389/fnut.2022.847421

    4 Insights on

    • Reduced Cancer Mortality
    • Reduced Cancer Incidence
    • Reduced Lung Cancer Incidence
    • Reduced Prostate Cancer Incidence

    • High evidence
• March 7

  • Overview of the Importance of Biotics in Gut Barrier Integrity.

    • 2022-03-07
    • Review
    • International journal of molecular sciences 23(5)
    • • Aleksandra Maria Kocot
      • Elżbieta Jarocka-Cyrta
      • Natalia Drabińska

    • PubMed: 35270039
    • DOI: 10.3390/ijms23052896

    1 Insight on

    • Improved Gut Barrier Function

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Perilla seed oil in combination with nobiletin-rich ponkan powder enhances cognitive function in healthy elderly Japanese individuals: a possible supplement for brain health in the elderly.

    • 2022-03-07
    • RCT
    • Food & function 13(5)
    • • Michio Hashimoto
      • Kentaro Matsuzaki
      • Koji Maruyama
      • Shahdat Hossain
      • Eri Sumiyoshi
      • Harumi Wakatsuki
      • Setsushi Kato
      • Miho Ohno
      • Yoko Tanabe
      • Yoko Kuroda
      • Shuhei Yamaguchi
      • Koji Kajima
      • Yasushi Ohizumi
      • Osamu Shido

    • PubMed: 35171190
    • DOI: 10.1039/d1fo03508h

    1 Insight on

    • Improved Cognitive Function

    • High evidence
    • Rigorous Journal

  • Investigating the effect of quadruple therapy with Saccharomyces boulardii or Lactobacillus reuteri strain (DSMZ 17648) supplements on eradication of Helicobacter pylori and treatments adverse effects: a double-blind placebo-controlled randomized clinical trial.

    • 2022-03-07
    • RCT · n = 156
    • BMC gastroenterology 22(1)
    • • Nooshin Naghibzadeh
      • Fatemeh Salmani
      • Samira Nomiri
      • Tahmine Tavakoli

    • PubMed: 35255819
    • DOI: 10.1186/s12876-022-02187-z

    6 Insights on

    • Reduced Abdominal Pain
    • Reduced Headache
    • Reduced Diarrhea
    • Reduced Anxiety
    • Increased Helicobacter pylori Eradication
    • Reduced Nausea

    • High evidence
    • Large Human Trial

  • Epithelial Heat Shock Proteins Mediate the Protective Effects of Limosilactobacillus reuteri in Dextran Sulfate Sodium-Induced Colitis

    • 2022-03-07
    • RCT
    • Frontiers in Immunology 13
    • • Hao-Yu Liu
      • Fang Gu
      • C-H Zhu
      • Lijuan Yuan
      • Chuyang Zhu
      • M. Zhu
      • Jiacheng Yao
      • Ping Hu
      • Yunzeng Zhang
      • J. Dicksved
      • Wen-hua Bao
      • Demin Cai

    • PubMed: 35320932
    • DOI: 10.3389/fimmu.2022.865982

    8 Insights on

    • Reduced Neutrophil Recruitment
    • Reduced Colitis Severity
    • Increased Barrier-Preserving Protein Levels
    • Reduced Intestinal Inflammation
    • Reduced Pro-inflammatory Cytokine Levels
    • Counterbalanced Gut Dysbiosis
    • Improved Gut Barrier Function
    • Improved Th1/Th2 Balance

    • Low evidence
    • Animal Study

  • The Effect of Oral Probiotics (Streptococcus Salivarius k12) on the Salivary Level of Secretory Immunoglobulin A, Salivation Rate, and Oral Biofilm: A Pilot Randomized Clinical Trial

    • 2022-03-07
    • RCT · n = 31
    • Nutrients 14(5)
    • • K. Babina
      • Dilara Salikhova
      • M. Polyakova
      • Oxana A. Svitich
      • R. Samoylikov
      • S. A. Ahmad El-Abed
      • A. Zaytsev
      • N. Novozhilova

    • PubMed: 35268099
    • DOI: 10.3390/nu14051124

    6 Insights on

    • Increased Salivary Secretory Immunoglobulin A Levels
    • No Change in Salivary Secretory Immunoglobulin A Levels
    • Stable Salivation Rate
    • Increased Salivary Immunoglobulin A Secretion
    • Unchanged Salivary Flow Rates
    • Reduced Plaque Accumulation

    • High evidence
• March 8

  • Lacticaseibacillus paracasei sh2020 induced antitumor immunity and synergized with anti-programmed cell death 1 to reduce tumor burden in mice

    • 2022-03-08
    • Clinical Trial
    • Gut Microbes 14(1)
    • • Shilong Zhang
      • Bing Han
      • Yu-qin Mao
      • Zheng-yan Zhang
      • Zhan-ming Li
      • Chao‐Yue Kong
      • You Wu
      • Guoqiang Chen
      • Li‐Shun Wang

    • PubMed: 35259052
    • DOI: 10.1080/19490976.2022.2046246

    3 Insights on

    • Enhanced CD8+ T Cell Recruitment
    • Enhanced Antitumor Immunity
    • Improved Intestinal Barrier Function

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Assessment of the Effects of the Synbiotic Combination of Bifidobacterium longum subsp. infantis CECT 7210 and Oligofructose-Enriched Inulin Against Digestive Bacterial Infections in a Piglet Model

    • 2022-03-08
    • Clinical Trial · n = 168
    • Frontiers in Microbiology 13
    • • A. Rodríguez-Sorrento
      • L. Castillejos
      • Paola López-Colom
      • G. Cifuentes-Orjuela
      • J. A. Moreno-Muñoz
      • S. Martín-Orúe

    • PubMed: 35350617
    • DOI: 10.3389/fmicb.2022.831737

    1 Insight on

    • Increased Intestinal T-Cell Count

    • Low evidence
    • Animal Study
• March 9

  • Fermentation of Soybean Meal with Lactobacillus acidophilus Allows Greater Inclusion of Vegetable Protein in the Diet and Can Reduce Vibrionacea in the Intestine of the South American Catfish (Rhamdia quelen)

    • 2022-03-09
    • RCT · n = 140
    • Animals 12(6)
    • • Nandara Soares de Oliveira
      • N. Ha
      • Larissa da Cunha
      • Luiz Augusto Cipriani
      • A. T. Neto
      • E. Skoronski
      • E. Gisbert
      • Thiago El Hadi Perez Fabregat

    • PubMed: 35327087
    • DOI: 10.3390/ani12060690

    1 Insight on

    • Reduced Intestinal Pathogenic Bacteria

    • Low evidence
    • Rigorous Journal
    • Animal Study
• March 11

  • Influence of Orally Administered Probiotic Lactobacillus Strains on Vaginal Microbiota in Women with Breast Cancer during Chemotherapy: A Randomized Placebo-Controlled Double-Blinded Pilot Study.

    • 2022-03-11
    • RCT · n = 22
    • Breast care (Basel, Switzerland) 12(5)
    • • Julian Marschalek
      • Alex Farr
      • Marie-Louise Marschalek
      • Konrad J Domig
      • Wolfgang Kneifel
      • Christian F Singer
      • Herbert Kiss
      • Ljubomir Petricevic

    • PubMed: 29234255
    • DOI: 10.1159/000478994

    1 Insight on

    • Improved Vaginal Microbiota

    • High evidence

  • Prevention of High-Fat Diet-Induced Hypercholesterolemia by Lactobacillus reuteri Fn041 Through Promoting Cholesterol and Bile Salt Excretion and Intestinal Mucosal Barrier Functions

    • 2022-03-11
    • Clinical Trial
    • Frontiers in Nutrition 9
    • • Mengyao Lu
      • Jin Sun
      • Yuning Zhao
      • Haowen Zhang
      • Xinyue Li
      • Jingbo Zhou
      • Hongyang Dang
      • Jidong Zhang
      • Wenjing Huang
      • Ce Qi
      • Duo Li

    • PubMed: 35369106
    • DOI: 10.3389/fnut.2022.851541

    6 Insights on

    • Increased Bile Acid Excretion
    • Reduced Hypercholesterolemia Incidence
    • Improved Intestinal Barrier Function
    • Increased Cholesterol Excretion
    • Prevention of Hypercholesterolemia
    • Prevention of Intestinal Dysbiosis

    • Low evidence
    • Animal Study
• March 14

  • Lactiplantibacillus plantarum DMDL 9010 alleviates dextran sodium sulfate (DSS)-induced colitis and behavioral disorders by facilitating microbiota-gut-brain axis balance.

    • 2022-03-14
    • Clinical Trial
    • Food & Function 13(1)
    • • Yan‐yan Huang
      • Yanan Wu
      • Xiang-ze Jia
      • Jin Lin
      • Lanlan Xiao
      • Dong‐mei Liu
      • Ming-Hua Liang

    • PubMed: 34913458
    • DOI: 10.1039/d1fo02938j

    6 Insights on

    • Reduced Neuroinflammation
    • Reduced Inflammatory Response
    • Increased Short-Chain Fatty Acid Levels
    • Reduced Depression-like Behavior
    • Improved Intestinal Barrier Function
    • Enhanced Beneficial Gut Microbiota

    • Low evidence
    • Animal Study

  • Saccharomyces boulardii alleviates DSS-induced intestinal barrier dysfunction and inflammation in humanized mice.

    • 2022-03-14
    • Clinical Trial
    • Food & Function 13(1)
    • • Bei Li
      • Haibo Zhang
      • Linlin Shi
      • Rong Li
      • Yanan Luo
      • Yun Deng
      • Shihan Li
      • Ruizhen Li
      • Zhi Liu

    • PubMed: 34878454
    • DOI: 10.1039/d1fo02752b

    3 Insights on

    • Regulated Inflammatory Responses
    • Improved Colonic Health
    • Increased SCFA Levels

    • Low evidence
    • Animal Study
• March 15

  • Live Lactobacillus acidophilus alleviates ulcerative colitis via the SCFAs/mitophagy/NLRP3 inflammasome axis.

    • 2022-03-15
    • Clinical Trial
    • Food & Function 13(5)
    • • Pei Li
      • Guoping Chen
      • Jiaxian Zhang
      • Chaoying Pei
      • Ying Chen
      • Jing Gong
      • S. Deng
      • Kaiwei Cai
      • Haiyan Li
      • Dawei Wang
      • Baochun Shen
      • Zhiyong Xie
      • Q. Liao

    • PubMed: 35195119
    • DOI: 10.1039/d1fo03360c

    13 Insights on

    • Improved Inflammation Homeostasis
    • Improved Immune Function
    • Increased Short-Chain Fatty Acids (SCFAs) Contents
    • Achieved Inflammation Homeostasis
    • Enhanced Autophagy
    • Improved Intestinal Barrier Function
    • Maintained Gut Microbiota Stability
    • Reduced Colitis Symptoms
    • Facilitated Mitophagy
    • Activated Mitophagy Pathway
    • Reduced Gut Disorders
    • Reduced Ulcerative Colitis Symptoms
    • Increased Short-Chain Fatty Acid Levels

    • Low evidence
    • Animal Study

  • Intestinal Mucosal Immunity-Mediated Modulation of the Gut Microbiome by Oral Delivery of Enterococcus faecium Against Salmonella Enteritidis Pathogenesis in a Laying Hen Model

    • 2022-03-15
    • RCT · n = 400
    • Frontiers in Immunology 13
    • • Shimeng Huang
      • Xiao Rong
      • Meiling Liu
      • Z. Liang
      • Y. Geng
      • Xinyue Wang
      • Jianyun Zhang
      • C. Ji
      • Lihong Zhao
      • Qiugang Ma

    • PubMed: 35371085
    • DOI: 10.3389/fimmu.2022.853954

    7 Insights on

    • Improved Immune Function
    • Improved Intestinal Function
    • Reduced Triglyceride Levels
    • Improved Intestinal Barrier Function
    • Reduced Hepatic Oxidative Stress
    • Reduced Oxidative Stress
    • Improved Gut Microbial Dysbiosis

    • Low evidence
    • Animal Study

  • Engineered Probiotic Lactococcus lactis for Lycopene Production against ROS Stress in Intestinal Epithelial Cells.

    • 2022-03-15
    • ACS Synthetic Biology 11(4)
    • • Jiapeng Wu
      • Xingfang Tian
      • Xiaoning Xu
      • X. Gu
      • J. Kong
      • T. Guo

    • PubMed: 35289165
    • DOI: 10.1021/acssynbio.1c00639

    2 Insights on

    • Reduced Oxidative Stress in Intestinal Epithelial Cells
    • Improved Cell Survival Rates

    • Low evidence
• March 17

  • Oral administration of Lactobacillus delbrueckii enhances intestinal immunity through inducing dendritic cell activation in suckling piglets.

    • 2022-03-17
    • Clinical Trial
    • Food & Function 13(5)
    • • Wei Peng
      • Yinghui Li
      • Guan Yang
      • Jie-Lin Duan
      • Lingyuan Yang
      • Li-Xiang Chen
      • Shuling Hou
      • Xingguo Huang

    • PubMed: 35166282
    • DOI: 10.1039/d1fo03864h

    9 Insights on

    • Elevated Serum TNF-α Levels
    • Increased Ileum Interleukin-10 Levels
    • Increased Dendritic Cell Activation
    • Long-Lasting Immunomodulatory Effects After Weaning
    • Enhanced Intestinal Immunity
    • Elevated Ileum IL-4 Levels
    • Improved Microbial Diversity
    • Improved Gut Microbiota Diversity
    • Improved Dendritic Cell Activation

    • Low evidence
    • Animal Study
• March 18

  • The impact of Moringa oleifera leaf supplementation on human and animal nutrition, growth, and milk production: A systematic review.

    • 2022-03-18
    • Systematic Review
    • Phytotherapy research : PTR 36(4)
    • • Sumeer Brar
      • Carolyn Haugh
      • Nicole Robertson
      • Patrick Mbullo Owuor
      • Carrie Waterman
      • George J Fuchs
      • Suzanna Labib Attia

    • PubMed: 35302264
    • DOI: 10.1002/ptr.7415

    4 Insights on

    • Increased Breastmilk Volume
    • Increased Hemoglobin Levels
    • Improved Vitamin A Level
    • Increased Body Mass Index

    • High evidence
• March 19

  • Nasal administration of a probiotic assemblage in allergic rhinitis: A randomised placebo-controlled crossover trial.

    • 2022-03-19
    • RCT · n = 24
    • Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 52(6)
    • • Anders Mårtensson
      • Franziska U Nordström
      • Charlotte Cervin-Hoberg
      • Malin Lindstedt
      • Christina Sakellariou
      • Anders Cervin
      • Lennart Greiff

    • PubMed: 35075723
    • DOI: 10.1111/cea.14098

    2 Insights on

    • Reduced Nasal Colonization
    • Reduced Nasal Inflammation

    • High evidence

  • Stevia rebaudiana Bertoni and its secondary metabolites: Their effects on cardiovascular risk factors.

    • 2022-03-19
    • Review
    • Nutrition (Burbank, Los Angeles County, Calif.) 99
    • • Beata Olas

    • PubMed: 35588653
    • DOI: 10.1016/j.nut.2022.111655

    1 Insight on

    • Reduced Blood Pressure

    • Low evidence
• March 20

  • Brown and golden flaxseed reduce intestinal permeability and endotoxemia, and improve the lipid profile in perimenopausal overweight women.

    • 2022-03-20
    • RCT
    • International journal of food sciences and nutrition 73(6)
    • • Cíntia Tomaz Sant'Ana
      • Ariane Dias de Amorim
      • Ana Paula Gava
      • Carla Mora Aguilar
      • Nayana Garcia Silva
      • Líllian Duarte Machado
      • Mirelle Lomar Viana
      • Daniela da Silva Oliveira
      • Pollyanna Ibrahim Silva
      • Neuza Maria Brunoro Costa
      • André Gustavo Vasconcelos Costa

    • PubMed: 35311432
    • DOI: 10.1080/09637486.2022.2052820

    5 Insights on

    • Reduced Intestinal Permeability
    • Reduced Metabolic Endotoxemia
    • Reduced Low-Density Lipoprotein Level
    • Reduced Fasting Blood Glucose
    • Reduced Oxidative Stress

    • High evidence
• March 21

  • Lactiplantibacillus Plantarum CCFM8724 Reduces the Amounts of Oral Pathogens and Alters the Oral Microbiota in Children With Dental Caries: a Randomized, Double-Blind, Placebo-Controlled Trial.

    • 2022-03-21
    • RCT
    • Journal of the American Nutrition Association 42(4)
    • • Qiuxiang Zhang
      • Baokun Shan
      • Xian Xu
      • Bingyong Mao
      • Xin Tang
      • Jianxin Zhao
      • Hao Zhang
      • Shumao Cui
      • Wei Chen

    • PubMed: 35512770
    • DOI: 10.1080/07315724.2022.2043200

    2 Insights on

    • Altered Oral Microbiota
    • Reduced Oral Pathogen Growth

    • High evidence
• March 23

  • Bifidobacterium spp. as functional foods: A review of current status, challenges, and strategies

    • 2022-03-23
    • Review
    • Critical Reviews in Food Science and Nutrition 63(26)
    • • Baolin He
      • Yong Xiong
      • Teng-gen Hu
      • Min-hua Zong
      • Hong Wu

    • PubMed: 35319324
    • DOI: 10.1080/10408398.2022.2054934

    3 Insights on

    • Nervous System Dysfunction in Host
    • Improved Digestive Function
    • Enhanced Immune Function

    • Low evidence

  • Can probiotic gargles reduce post-tonsillectomy morbidity in adult patients? A pilot, triple-blind, randomised, controlled trial and feasibility study.

    • 2022-03-23
    • RCT
    • The Journal of laryngology and otology 137(3)
    • • M V Nasserallah
      • N M de Silva
      • V Tobin
      • W M Rozen
      • D J Hunter-Smith

    • PubMed: 35317870
    • DOI: 10.1017/s0022215122000743

    3 Insights on

    • Adverse Effects Frequency
    • Reduced Postoperative Pain
    • Reduced Post-Tonsillectomy Bleeding

    • High evidence
• March 25

  • Bacteriocin-Producing Strain Lactiplantibacillus plantarum LP17L/1 Isolated from Traditional Stored Ewe’s Milk Cheese and Its Beneficial Potential

    • 2022-03-25
    • Foods 11(7)
    • • A. Lauková
      • M. Tomáška
      • M. Fraqueza
      • R. Szabóová
      • E. Bino
      • J. Ščerbová
      • M. Pogány Simonová
      • E. Dvorožňáková

    • PubMed: 35407045
    • DOI: 10.3390/foods11070959

    4 Insights on

    • Reduced Coliform Levels in the Jejunum
    • Improved Safe Consumption Practices
    • Enhanced Survival Without Side Effects
    • Reduced Gastrointestinal Coliforms

    • Low evidence
    • Rigorous Journal
• March 28

  • Lactobacillus salivarius CML352 Isolated from Chinese Local Breed Chicken Modulates the Gut Microbiota and Improves Intestinal Health and Egg Quality in Late-Phase Laying Hens

    • 2022-03-28
    • Microorganisms 10(4)
    • • Chang Xu
      • Fuxiao Wei
      • Xinyue Yang
      • Yuqing Feng
      • Dan Liu
      • Yongfei Hu

    • PubMed: 35456777
    • DOI: 10.3390/microorganisms10040726

    4 Insights on

    • Improved Intestinal Mucosal Immunity
    • Reduced Visceral Fat
    • Improved Intestinal Function
    • Improved Gastrointestinal Health

    • Low evidence
    • Rigorous Journal

  • Safety and the probiotic potential of Bifidobacterium animalis CP-9.

    • 2022-03-28
    • Clinical Trial
    • Journal of Food Science 87(5)
    • • Hui-Yun Tsai
      • Ya-Chin Wang
      • Chorng-An Liao
      • Chia-Yan Su
      • Cheng-Hsieh Huang
      • Min-Hsi Chiu
      • Yao-Tsung Yeh

    • PubMed: 35347713
    • DOI: 10.1111/1750-3841.16129

    2 Insights on

    • Enhanced Intestinal Epithelial Cell Adhesion
    • Reduced Oleic Acid-Induced Triglyceride Accumulation

    • Low evidence
    • Animal Study
• March 29

  • Tibetan Pig-Derived Probiotic Lactobacillus amylovorus SLZX20-1 Improved Intestinal Function via Producing Enzymes and Regulating Intestinal Microflora

    • 2022-03-29
    • Frontiers in Nutrition 9
    • • Jiakun Shen
      • Jie Zhang
      • Ying Zhao
      • Zi-Qi Lin
      • Linbao Ji
      • Xi Ma

    • PubMed: 35425795
    • DOI: 10.3389/fnut.2022.846991

    5 Insights on

    • Improved Antibacterial Activity
    • Enhanced Host Defense Peptides Activation
    • Increased Host Defense Peptide Levels
    • Reduced Crypt Depth
    • Improved Intestinal Function

    • Low evidence

  • Lacticaseibacillus rhamnosus GG Counteracts Rotavirus-Induced Ion Secretion and Enterocyte Damage by Inhibiting Oxidative Stress and Apoptosis Through Specific Effects of Living and Postbiotic Preparations

    • 2022-03-29
    • Frontiers in Cellular and Infection Microbiology 12
    • • V. Buccigrossi
      • M. Poeta
      • Valentina Cioffi
      • Sara Terranova
      • F. Nunziata
      • A. Lo Vecchio
      • A. Guarino

    • PubMed: 35425719
    • DOI: 10.3389/fcimb.2022.854989

    2 Insights on

    • Protected Enterocyte Structure
    • Reduced Diarrhea Symptoms

    • Low evidence
• Undated – 7 supplement studies

  • Intestinal microbiota and its interaction to intestinal health in nursery pigs.

    • 2022-03
    • Review
    • Animal nutrition (Zhongguo xu mu shou yi xue hui) 8
    • • Marcos Elias Duarte
      • Sung Woo Kim

    • PubMed: 34977387
    • DOI: 10.1016/j.aninu.2021.05.001

    2 Insights on

    • Improved Intestinal Health
    • Improved Growth Performance

    • Low evidence

  • Fermentation of kiwifruit juice from two cultivars by probiotic bacteria: Bioactive phenolics, antioxidant activities and flavor volatiles.

    • 2022-03
    • Food chemistry 373
    • • Zining Wang
      • Yunzi Feng
      • Nana Yang
      • Tian Jiang
      • Huaide Xu
      • Hongjie Lei

    • PubMed: 34731808
    • DOI: 10.1016/j.foodchem.2021.131455

    2 Insights on

    • Increased Antioxidant Capacity
    • Improved Flavor Perception

    • Low evidence

  • Effects of Panax ginseng on hyperglycemia, hypertension, and hyperlipidemia: A systematic review and meta-analysis.

    • 2022-03
    • Review · n = 23
    • Journal of ginseng research 46(2)
    • • Soo Hyun Park
      • Sangwon Chung
      • Min-Yu Chung
      • Hyo-Kyoung Choi
      • Jin-Taek Hwang
      • Jae Ho Park

    • PubMed: 35509826
    • DOI: 10.1016/j.jgr.2021.10.002

    9 Insights on

    • Reduced Glucose Area Under the Curve
    • Reduced Insulin Area Under the Curve
    • Reduced Blood Glucose Levels
    • Reduced Systolic Blood Pressure
    • Reduced Blood Cholesterol
    • Reduced Low-Density Lipoprotein Level
    • Reduced Triglyceride Levels
    • Reduced Diastolic Blood Pressure
    • Reduced Body Fat

    • Low evidence

  • Effect of L-Carnitine Supplementation on Inflammatory Markers and Serum Glucose in Hemodialysis Children: A Randomized, Placebo-Controlled Clinical Trial.

    • 2022-03
    • RCT · n = 12
    • Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 32(2)
    • • Fatemeh Hamedi-Kalajahi
      • Hossein Imani
      • SayedYousef Mojtahedi
      • Sakineh Shabbidar

    • PubMed: 34740538
    • DOI: 10.1053/j.jrn.2021.03.009

    5 Insights on

    • Reduced Fasting Blood Glucose Levels
    • Increased Serum Albumin Levels
    • Reduced High-Sensitivity C-Reactive Protein Level
    • Reduced Interleukin-6 Levels
    • Improved Quality of Life

    • High evidence

  • L-Citrulline supplementation attenuates aortic pulse pressure and wave reflection responses to cold stress in older adults.

    • 2022-03
    • RCT
    • Experimental gerontology 159
    • • Salvador J Jaime
      • Jessica Nagel
      • Arun Maharaj
      • Stephen M Fischer
      • Elizabeth Schwab
      • Christopher Martinson
      • Kim Radtke
      • Richard P Mikat
      • Arturo Figueroa

    • PubMed: 34990772
    • DOI: 10.1016/j.exger.2021.111685

    8 Insights on

    • Reduced Augmented Pressure
    • Reduced Forward Wave Pressure
    • Reduced Augmentation Index
    • Reduced Augmentation Index at 75 bpm
    • Reduced Backward Wave Pressure
    • Reduced Aortic Systolic Blood Pressure
    • Reduced Diastolic Blood Pressure
    • Reduced Aortic Pulse Pressure

    • High evidence

  • A randomised controlled trial of a probiotic and a prebiotic examining metabolic and mental health outcomes in adults with pre-diabetes

    • 2022-03
    • RCT · n = 153
    • BMJ Open 12(3)
    • • C. Barthow
      • Fiona Hood
      • Julian Crane
      • Mark Huthwaite
      • M. Weatherall
      • A. Parry-Strong
      • J. Krebs

    • PubMed: 35332040
    • DOI: 10.1136/bmjopen-2021-055214

    3 Insights on

    • Improved Fasting Plasma Glucose
    • Reduced Blood HbA1c Levels
    • Improved Mental Well-Being

    • High evidence
    • Rigorous Journal

  • The efficacy of adjuvant N acetyl cysteine for the eradication of H pylori infections: A systematic review and meta-analysis of randomized clinical trials.

    • 2022-03
    • Meta-Analysis · n = 1,167
    • Clinics and research in hepatology and gastroenterology 46(3)
    • • Dr Pritam Biswas
      • Dr Sukumar Tk

    • PubMed: 34775122
    • DOI: 10.1016/j.clinre.2021.101832

    1 Insight on

    • Increased H. pylori Eradication Rate

    • High evidence