February 2021 Supplement Research Papers

• February 1

  • Effects of Ganoderma lucidum and Ceratonia siliqua on blood glucose, lipid profile, and body composition in women with fibromyalgia.

    • 2021-02-01
    • RCT
    • Nutricion hospitalaria 38(1)
    • • Francesco Pazzi
      • José Carmelo Adsuar
      • Francisco Javier Domínguez-Muñoz
      • Miguel Ángel García-Gordillo
      • Narci Gusi
      • Daniel Collado-Mateo

    • PubMed: 33319566
    • DOI: 10.20960/nh.03190

    8 Insights on

    • Reduced Waist-to-Height Ratio
    • Reduced Body Weight
    • Reduced Blood Pressure
    • Reduced Triglyceride Levels
    • Increased Muscle Mass
    • Reduced Body Fat Mass
    • Reduced Blood Cholesterol
    • Reduced Fasting Blood Glucose Levels

    • High evidence
• February 2

  • Functional role of surface layer proteins of Lactobacillus acidophilus L-92 in stress tolerance and binding to host cell proteins

    • 2021-02-02
    • Bioscience of Microbiota, Food and Health 40(1)
    • • Taketo Wakai
      • C. Kano
      • Harma A. Karsens
      • J. Kok
      • N. Yamamoto

    • PubMed: 33520567
    • DOI: 10.12938/bmfh.2020-005

    3 Insights on

    • Improved Immune Modulation
    • Improved Stress Tolerance
    • Modulated Cytokine Levels

    • Low evidence
    • Rigorous Journal
• February 4

  • Plant Glycan Metabolism by Bifidobacteria

    • 2021-02-04
    • Frontiers in Microbiology 12
    • • S. Kelly
      • J. Munoz-Munoz
      • D. van Sinderen

    • PubMed: 33613480
    • DOI: 10.3389/fmicb.2021.609418

    1 Insight on

    • Improved Gut Microbiome Health

    • Low evidence
• February 5

  • NB-UVB plus oral Polypodium leucotomos extract display higher efficacy than NB-UVB alone in patients with vitiligo.

    • 2021-02-05
    • RCT · n = 21
    • Dermatologic therapy 34(2)
    • • Alessia Pacifico
      • Giovanni Damiani
      • Paolo Iacovelli
      • Rosalynn R Z Conic
      • Salvador Gonzalez
      • Aldo Morrone

    • PubMed: 33433041
    • DOI: 10.1111/dth.14776

    2 Insights on

    • Increased Response Rate
    • Improved Repigmentation

    • High evidence
• February 9

  • The effect of Eurycoma Longifolia on the regulation of reproductive hormones in young males.

    • 2021-02-09
    • RCT
    • Andrologia 53(4)
    • • Kai Quin Chan
      • Claire Stewart
      • Neil Chester
      • Sareena H Hamzah
      • Ashril Yusof

    • PubMed: 33559971
    • DOI: 10.1111/and.14001

    5 Insights on

    • Increased Estradiol Level
    • Increased Testosterone Level
    • Increased Sex Hormone-Binding Globulin Level
    • Increased Luteinizing Hormone Level
    • Increased Follicle-Stimulating Hormone Level

    • High evidence
• February 10

  • Early and sustained Lactobacillus plantarum probiotic therapy in critical illness: the randomised, placebo-controlled, restoration of gut microflora in critical illness trial (ROCIT)

    • 2021-02-10
    • RCT · n = 218
    • Intensive Care Medicine 47(3)
    • • E. Litton
      • M. Anstey
      • David I. Broadhurst
      • A. Chapman
      • A. Currie
      • J. Ferrier
      • J. Gummer
      • A. Higgins
      • Jolene Lim
      • L. Manning
      • E. Myers
      • Katrina Orr
      • Anne-Marie Palermo
      • A. Paparini
      • S. Pellicano
      • E. Raby
      • A. Rammohan
      • A. Regli
      • Bernhard Richter
      • S. Salman
      • T. Strunk
      • S. Waterson
      • D. Weight
      • B. Wibrow
      • F. Wood

    • PubMed: 33566129
    • DOI: 10.1007/s00134-020-06322-w

    8 Insights on

    • Improved Survival Rate
    • Increased Adverse Events
    • Reduced Mortality Risk
    • Reduced Nosocomial Infection Rate
    • Improved Overall Patient Outcomes
    • Reduced Nosocomial Infection Incidence
    • Adverse Events from Probiotics
    • Increased Days Alive and Out of Hospital

    • High evidence
    • Rigorous Journal
• February 11

  • Monoassociation of Preterm Germ-Free Piglets with Bifidobacterium animalis Subsp. lactis BB-12 and Its Impact on Infection with Salmonella Typhimurium.

    • 2021-02-11
    • Biomedicines 9(2)
    • • Alla Splichalova
      • Sharon M Donovan
      • Helena Tlaskalova-Hogenova
      • Zbynek Stranak
      • Zdislava Splichalova
      • Igor Splichal

    • PubMed: 33670419
    • DOI: 10.3390/biomedicines9020183

    3 Insights on

    • Improved Intestinal Structure
    • Reduced Intestinal Tissue Damage
    • No Significant Improvement in Clinical Signs of Salmonellosis

    • Low evidence
• February 12

  • Ingestion of probiotic (Lactobacillus helveticus and Bifidobacterium longum) alters intestinal microbial structure and behavioral expression following social defeat stress

    • 2021-02-12
    • Clinical Trial
    • Scientific Reports 11(1)
    • • Katherine A. Partrick
      • Anna M. Rosenhauer
      • J. Auger
      • A. R. Arnold
      • Nicole M. Ronczkowski
      • Lanaya M Jackson
      • Magen N Lord
      • S. M. Abdulla
      • B. Chassaing
      • K. Huhman

    • PubMed: 33580118
    • DOI: 10.1038/s41598-021-83284-z

    3 Insights on

    • Increased Anti-Inflammatory Cytokine Levels
    • Increased Social Avoidance
    • Reduced Microbial Richness

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Pumpkin seed oil vs. minoxidil 5% topical foam for the treatment of female pattern hair loss: A randomized comparative trial.

    • 2021-02-12
    • RCT · n = 30
    • Journal of cosmetic dermatology 20(9)
    • • Ibrahim M Ibrahim
      • Mohamed S Hasan
      • Khaled I Elsabaa
      • Mohamed L Elsaie

    • PubMed: 33544448
    • DOI: 10.1111/jocd.13976

    3 Insights on

    • Reduced Hair Shaft Diversity
    • Reduced Vellus Hair
    • Increased Regrowing Hair Count

    • High evidence
• February 14

  • Acacia Gum Is Well Tolerated While Increasing Satiety and Lowering Peak Blood Glucose Response in Healthy Human Subjects.

    • 2021-02-14
    • RCT
    • Nutrients 13(2)
    • • Riley Larson
      • Courtney Nelson
      • Renee Korczak
      • Holly Willis
      • Jennifer Erickson
      • Qi Wang
      • Joanne Slavin

    • PubMed: 33672963
    • DOI: 10.3390/nu13020618

    5 Insights on

    • Reduced Blood Glucose Levels
    • Increased Blood Glucose Levels
    • Reduced Hunger
    • Increased Fullness
    • Increased Satisfaction

    • High evidence
    • Rigorous Journal

  • The effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of tumor necrosis factor-α? A systematic review and meta-analysis of randomized controlled trials.

    • 2021-02-14
    • Meta-Analysis
    • Phytotherapy research : PTR 35(7)
    • • Mitra Hariri
      • Hamid Reza Baradaran
      • Ali Gholami

    • PubMed: 33586244
    • DOI: 10.1002/ptr.7047

    1 Insight on

    • Reduced Tumor Necrosis Factor Alpha

    • High evidence
• February 16

  • Pediococcus pentosaceus, a future additive or probiotic candidate

    • 2021-02-16
    • Microbial Cell Factories 20(1)
    • • Shiman Jiang
      • L. Cai
      • L. Lv
      • Lanjuan Li

    • PubMed: 33593360
    • DOI: 10.1186/s12934-021-01537-y

    4 Insights on

    • Increased Antioxidant Activity
    • Enhanced Detoxification
    • Reduced Cancer Incidence
    • Reduced Lipid Levels

    • Low evidence
    • Highly Cited
• February 17

  • Lactobacillus plantarum 299v probiotic supplementation in men with stable coronary artery disease suppresses systemic inflammation.

    • 2021-02-17
    • Clinical Trial · n = 15
    • Scientific reports 11(1)
    • • Benjamin C Hofeld
      • Venkata K Puppala
      • Sudhi Tyagi
      • Kwang Woo Ahn
      • Amberly Anger
      • Shuang Jia
      • Nita H Salzman
      • Martin J Hessner
      • Michael E Widlansky

    • PubMed: 33597583
    • DOI: 10.1038/s41598-021-83252-7

    3 Insights on

    • Reduced Inflammatory Response
    • Reduced Inflammation
    • Improved Vascular Endothelial Function

    • High evidence
    • Rigorous Journal
• February 19

  • Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review.

    • 2021-02-19
    • Systematic Review
    • Current drug discovery technologies 18(2)
    • • Maryam Azimi
      • Mohammad Javad Zahedi

    • PubMed: 32525777
    • DOI: 10.2174/1570163817666200611132831

    1 Insight on

    • Improved Functional Dyspepsia Symptoms

    • High evidence
• February 20

  • Microorganisms: A Potential Source of Bioactive Molecules for Antioxidant Applications.

    • 2021-02-20
    • Review
    • Molecules (Basel, Switzerland) 26(4)
    • • Alka Rani
      • Khem Chand Saini
      • Felix Bast
      • Sanjeet Mehariya
      • Shashi Kant Bhatia
      • Roberto Lavecchia
      • Antonio Zuorro

    • PubMed: 33672774
    • DOI: 10.3390/molecules26041142

    4 Insights on

    • Improved Skin Hydration
    • Improved Lipid Metabolism
    • Reduced Body Fat
    • Improved Skin Elasticity

    • Low evidence
• February 21

  • The Medical Benefits of Vitamin K2 on Calcium-Related Disorders.

    • 2021-02-21
    • Review
    • Nutrients 13(2)
    • • Zeyad Khalil
      • Benyamin Alam
      • Amir Reza Akbari
      • Harbans Sharma

    • PubMed: 33670005
    • DOI: 10.3390/nu13020691

    5 Insights on

    • Improved Bone Mass Density
    • Improved Motor Function
    • Improved Sperm Motility
    • Reduced Cardiovascular Disease Risk
    • Improved Parathyroid Function

    • Moderate evidence
    • Rigorous Journal
• February 22

  • The protective mechanism of Lactobacillus plantarum FZU3013 against non-alcoholic fatty liver associated with hyperlipidemia in mice fed a high-fat diet.

    • 2021-02-22
    • Clinical Trial
    • Food & Function 11(4)
    • • Min Chen
      • Wei-ling Guo
      • Qiu-Yi Li
      • Jia-Xin Xu
      • Ying-Jia Cao
      • B. Liu
      • Xiao-Dan Yu
      • P. Rao
      • Li Ni
      • Xu-Cong Lv

    • PubMed: 32226996
    • DOI: 10.1039/c9fo03003d

    6 Insights on

    • Reduced Body Weight
    • Reduced Liver Lipid Accumulation
    • Reduced Serum Cholesterol Levels
    • Reduced LDL Cholesterol
    • Increased Bile Acid Excretion
    • Regulated Liver Metabolite Levels

    • Low evidence
    • Animal Study

  • Neurodevelopmental Outcomes and Gut Bifidobacteria in Term Infants Fed an Infant Formula Containing High sn-2 Palmitate: A Cluster Randomized Clinical Trial

    • 2021-02-22
    • RCT · n = 199
    • Nutrients 13(2)
    • • Wei Wu
      • A. Zhao
      • Biao Liu
      • Wenhui Ye
      • Hongzhu Su
      • Jing Li
      • Yu-Mei Zhang

    • PubMed: 33671493
    • DOI: 10.3390/nu13020693

    2 Insights on

    • Increased Gut Bifidobacteria
    • Improved Fine Motor Skills

    • High evidence
• February 23

  • Lipoteichoic acid from Bifidobacterium animalis subsp. lactis BPL1: a novel postbiotic that reduces fat deposition via IGF‐1 pathway

    • 2021-02-23
    • Clinical Trial
    • Microbial Biotechnology 15(3)
    • • Ferrán Balaguer
      • M. Enrique
      • S. Llopis
      • M. Barrena
      • Verónica Navarro
      • Beatriz Alvarez
      • E. Chenoll
      • D. Ramón
      • M. Tortajada
      • P. Martorell

    • PubMed: 33620143
    • DOI: 10.1111/1751-7915.13769

    1 Insight on

    • Reduced Fat Deposition

    • Low evidence
    • Animal Study

  • In Vivo Transcriptome of Lactobacillus acidophilus and Colonization Impact on Murine Host Intestinal Gene Expression

    • 2021-02-23
    • mBio 12(1)
    • • Y. Goh
      • R. Barrangou
      • T. Klaenhammer

    • PubMed: 33500337
    • DOI: 10.1128/mBio.03399-20

    11 Insights on

    • Reduced Pro-Inflammatory Cytokines
    • Reduced Inflammatory Response
    • Reduced Inflammation Levels
    • Reduced Pro-inflammatory Cytokine Levels
    • Enhanced Immune Function
    • Improved Gut Homeostasis
    • Adjusted Immune Function
    • Enhanced Intestinal Development
    • Maintained Intestinal Epithelial Homeostasis
    • Regulated Circadian-Metabolic Axis
    • Improved Circadian-Metabolic Function

    • Low evidence

  • The effect of N-acetyl cysteine on the volume of uterine leiomyoma: A randomized clinical trial.

    • 2021-02-23
    • RCT · n = 25
    • International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 154(3)
    • • Shahrzad Aghaamoo
      • Azade Zandbina
      • Elham Saffarieh
      • Setare Nassiri

    • PubMed: 33480045
    • DOI: 10.1002/ijgo.13611

    1 Insight on

    • Reduced Leiomyoma Volume

    • High evidence
• February 24

  • Efficacy of Bifidobacterium breve CECT7263 for infantile colic treatment: an open-label, parallel, randomised, controlled trial.

    • 2021-02-24
    • RCT · n = 150
    • Beneficial Microbes 12(1)
    • • J. Maldonado-Lobón
      • R. Blanco-Rojo
      • J. Maldonado
      • M. A. Ali
      • M. V. Almazán
      • A. Suanes-Cabello
      • E. Callejón
      • R. Jaldo
      • M. R. Benavides
      • A. Negrillo
      • A. Sañudo
      • C. Rodríguez
      • O. Bañuelos
      • J. Fonollá
      • M. Olivares

    • PubMed: 33350361
    • DOI: 10.3920/BM2020.0105

    4 Insights on

    • Reduced Crying Duration
    • Improved Sleep Quality
    • Improved Parental Mood
    • Reduced Crying Time

    • High evidence

  • Efficacy of Bifidobacterium breve CECT7263 for infantile colic treatment: an open-label, parallel, randomised, controlled trial.

    • 2021-02-24
    • RCT · n = 150
    • Beneficial microbes 12(1)
    • • J A Maldonado-Lobón
      • R Blanco-Rojo
      • J Maldonado
      • M A Ali
      • M V Almazán
      • A Suanes-Cabello
      • E Callejón
      • R Jaldo
      • M R Benavídes
      • A M Negrillo
      • A Sañudo
      • C Rodríguez
      • O Bañuelos
      • J Fonollá
      • M Olivares

    • PubMed: 33350361
    • DOI: 10.3920/bm2020.0105

    1 Insight on

    • Reduced Crying Time

    • High evidence
    • Large Human Trial
    • Rigorous Journal
• February 25

  • Traditional Bulgarian Dairy Products: Ethnic Foods with Health Benefits.

    • 2021-02-25
    • Review
    • Microorganisms 9(3)
    • • Penka Petrova
      • Ivan Ivanov
      • Lidia Tsigoriyna
      • Nadezhda Valcheva
      • Evgenia Vasileva
      • Tsvetomila Parvanova-Mancheva
      • Alexander Arsov
      • Kaloyan Petrov

    • PubMed: 33668910
    • DOI: 10.3390/microorganisms9030480

    5 Insights on

    • Improved Microbial Diversity
    • Improved Antimicrobial Ability
    • Improved Immune Modulation
    • Improved Gut Microbiome Health
    • Increased Bioactive Compound Production

    • Low evidence

  • Safety Assessment of Bacillus subtilis MB40 for Use in Foods and Dietary Supplements

    • 2021-02-25
    • Clinical Trial
    • Nutrients 13(3)
    • • Jessica L. Spears
      • R. Kramer
      • A. Nikiforov
      • Marisa O. Rihner
      • E. A. Lambert

    • PubMed: 33668992
    • DOI: 10.3390/nu13030733

    3 Insights on

    • Improved Tolerability
    • No Adverse Health Effects
    • No Observed Adverse Effect Level

    • High evidence
• February 26

  • Probiotics in Cosmetic and Personal Care Products: Trends and Challenges.

    • 2021-02-26
    • Review
    • Molecules (Basel, Switzerland) 26(5)
    • • Scarlett Puebla-Barragan
      • Gregor Reid

    • PubMed: 33652548
    • DOI: 10.3390/molecules26051249

    2 Insights on

    • Improved Skin Barrier Function
    • Improved Skin Health

    • Low evidence
• February 28

  • Examining the Gastrointestinal and Immunomodulatory Effects of the Novel Probiotic Bacillus subtilis DE111

    • 2021-02-28
    • RCT
    • International Journal of Molecular Sciences 22(5)
    • • Kimberley E. Freedman
      • Jessica L. Hill
      • Yuren Wei
      • Allegra R. Vazquez
      • Diana S. Grubb
      • Roxanne E. Trotter
      • Scott D. Wrigley
      • Sarah A. Johnson
      • M. Foster
      • T. Weir

    • PubMed: 33671071
    • DOI: 10.3390/ijms22052453

    2 Insights on

    • Improved Gastrointestinal Health
    • Increased Anti-Inflammatory Immune Cell Populations

    • High evidence

  • Enterococcus faecium R0026 Combined with Bacillus subtilis R0179 Prevent Obesity-Associated Hyperlipidemia and Modulate Gut Microbiota in C57BL/6 Mice

    • 2021-02-28
    • RCT · n = 40
    • Journal of Microbiology and Biotechnology 31(2)
    • • Jinli Huang
      • Juan Huang
      • Tianyi Yin
      • Huiyun Lv
      • Pengyu Zhang
      • Huajun Li

    • PubMed: 33144552
    • DOI: 10.4014/jmb.2009.09005

    5 Insights on

    • Reduced Body Weight
    • Improved Liver Steatosis
    • Improved Serum Lipids
    • Increased Bifidobacterium Species
    • Reduced Hyperlipidemia Symptoms

    • Low evidence
    • Animal Study
• Undated – 6 supplement studies

  • Bacillus coagulans 13002 and fructo-oligosaccharides improve the immunity of mice with immunosuppression induced by cyclophosphamide through modulating intestinal-derived and fecal microbiota.

    • 2021-02
    • Clinical Trial
    • Food Research International 140
    • • Shan Zhao
      • Xin Peng
      • Qin‐yu Zhou
      • Yan‐yan Huang
      • Xiang Rao
      • Jia-Lin Tu
      • Hong-Yi Xiao
      • Dong‐mei Liu

    • PubMed: 33648160
    • DOI: 10.1016/j.foodres.2020.109793

    9 Insights on

    • Improved Immune Function
    • Increased Barrier-Preserving Protein Levels
    • Reduced Harmful Gut Bacteria
    • Increased Beneficial Gut Bacteria
    • Increased Butyric Acid Production
    • Elevated Serum Immunoglobulin Levels
    • Alleviated Chemotherapy-Induced Injury
    • Improved Growth of Beneficial Bacteria
    • Reduced Growth of Harmful Bacteria

    • Low evidence
    • Animal Study

  • Bacillus subtilis-fermented products ameliorate the growth performance and alter cecal microbiota community in broilers under lipopolysaccharide challenge.

    • 2021-02
    • RCT
    • Poultry Science 100(2)
    • • Jiun-Yu Chen
      • Yu-Hsiang Yu

    • PubMed: 33518141
    • DOI: 10.1016/j.psj.2020.10.070

    5 Insights on

    • Improved Intestinal Barrier Function
    • Improved Average Daily Gain
    • Improved Growth Performance
    • Reduced Inflammation Levels
    • Increased Beneficial Gut Microbiota

    • High evidence
    • Rigorous Journal

  • Efficacy of a partially hydrolysed formula, with reduced lactose content and with Lactobacillus reuteri DSM 17938 in infant colic: A double blind, randomised clinical trial.

    • 2021-02
    • RCT
    • Clinical Nutrition 40(2)
    • • R. Turco
      • M. Russo
      • D. Bruzzese
      • A. Staiano

    • PubMed: 32600858
    • DOI: 10.1016/j.clnu.2020.05.048

    1 Insight on

    • Reduced Crying Duration

    • High evidence

  • Effects of exogenous probiotics on the gut microbiota and clinical outcomes in critically ill patients: a randomized controlled trial.

    • 2021-02
    • RCT · n = 61
    • Annals of Palliative Medicine 10(2)
    • • Jie Wang
      • Hui Ke
      • Kai-Xiong Liu
      • J. Qu

    • PubMed: 33040557
    • DOI: 10.21037/apm-20-202

    2 Insights on

    • Reduced Fever Duration
    • Reduced Incidence of Constipation

    • High evidence

  • Quantification and gene expression of Lactobacillus casei group species associated with dentinal lesions in early childhood caries

    • 2021-02
    • Observational · n = 38
    • The Saudi Dental Journal 33(2)
    • • A. C. A. Reis
      • D. S. Bezerra
      • Erika Nikitza Shiauha Hart-Chú
      • R. N. Stipp
      • S. Guedes
      • B. G. Neves
      • L. K. Rodrigues

    • PubMed: 33551619
    • DOI: 10.1016/j.sdentj.2020.01.006

    1 Insight on

    • Increased Expression of wzb Gene in Active Dentinal Caries

    • High evidence
    • Rigorous Journal

  • [Treatment of IBS with Lactobacillus plantarum 299v: Therapeutic success increases with length of treatment - real-life data of a non-interventional study in Germany].

    • 2021-02
    • Observational · n = 221
    • Zeitschrift fur Gastroenterologie 59(02)
    • • Heiner Krammer
      • Martin Storr
      • Ahmed Madisch
      • Julia Riffel

    • PubMed: 33556972
    • DOI: 10.1055/a-1340-0204

    20 Insights on

    • Improved Bowel Movement Frequency
    • Improved Quality of Life
    • Reduced Flatulence
    • Reduced Abdominal Pain
    • Reduced Diarrhea Rate
    • Reduced Diarrhea Frequency
    • Improved Irritable Bowel Syndrome Symptoms
    • Good Tolerability
    • Reduced Diarrhea Severity
    • Improved Tolerance
    • Improved Mental Well-Being
    • Reduced Sense of Incomplete Evacuation
    • Reduced Irritable Bowel Syndrome Symptoms
    • Well-Tolerated Long-Term Use
    • Reduced Overall Symptom Score
    • Reduced Constipation Severity
    • Reduced Urgency
    • Reduced Interference with Daily Life
    • Reduced Constipation Frequency
    • Reduced Impact of IBS on Daily Life

    • High evidence