January 2021 Supplement Research Papers

• January 1

  • Butyrate-producing human gut symbiont, Clostridium butyricum, and its role in health and disease

    • 2021-01-01
    • Review
    • Gut Microbes 13(1)
    • • Magdalena K. Stoeva
      • Jeewon Garcia-So
      • N. Justice
      • J. Myers
      • Surabhi Tyagi
      • Madeleine Nemchek
      • Paul J. McMurdie
      • O. Kolterman
      • J. Eid

    • PubMed: 33874858
    • DOI: 10.1080/19490976.2021.1907272

    7 Insights on

    • Reduced Intestinal Damage
    • Improved Metabolic Disease Markers
    • Improved Effectiveness in Inflammatory Bowel Disease
    • Improved Irritable Bowel Syndrome Symptoms
    • Reduced Colon Cancer Risk
    • Neuroprotection in Neurodegenerative Diseases
    • Increased Immunity to Gut-Acquired Infections

    • High evidence
    • Highly Cited
    • Rigorous Journal

  • Effects of Lactobacillus rhamnosus GG on early postoperative outcome after pylorus-preserving pancreatoduodenectomy: a randomized trial.

    • 2021-01-01
    • RCT · n = 20
    • European review for medical and pharmacological sciences 25(1)
    • • M Folwarski
      • M Dobosz
      • S Małgorzewicz
      • K Skonieczna-Żydecka
      • K Kaźmierczak-Siedlecka

    • PubMed: 33506929
    • DOI: 10.26355/eurrev_202101_24407

    7 Insights on

    • Improved Bowel Movement Frequency
    • Improved Flatulence Passage
    • Reduced Length of Hospital Stay
    • Reduced Infection Rate
    • Improved Stool Frequency
    • Improved Appetite
    • Reduced Mortality Risk

    • High evidence

  • Effects of Triphala on Lipid and Glucose Profiles and Anthropometric Parameters: A Systematic Review.

    • 2021-01-01
    • Systematic Review · n = 749
    • Journal of evidence-based integrative medicine 26
    • • Wiraphol Phimarn
      • Bunleu Sungthong
      • Hiroyuki Itabe

    • PubMed: 33886393
    • DOI: 10.1177/2515690x211011038

    7 Insights on

    • Reduced Body Weight
    • Reduced Blood Cholesterol
    • Reduced Body Mass Index
    • Reduced Low-Density Lipoprotein Level
    • Reduced Triglyceride Levels
    • Reduced Fasting Blood Glucose Levels
    • Reduced Waist Circumference

    • High evidence

  • Safety and efficacy of using heat-killed Lactobacillus plantarum L-137: High-dose and long-term use effects on immune-related safety and intestinal bacterial flora

    • 2021-01-01
    • Clinical Trial · n = 44
    • Journal of Immunotoxicology 18(1)
    • • Hiroko Nakai
      • S. Murosaki
      • Yoshihiro Yamamoto
      • M. Furutani
      • R. Matsuoka
      • Y. Hirose

    • PubMed: 34559598
    • DOI: 10.1080/1547691X.2021.1979698

    4 Insights on

    • Increased Fecal Acetic Acid Concentration
    • No Adverse Events Observed
    • Enhanced T-Cell Proliferation
    • Increased T-cell Proliferation at 12 Months

    • High evidence
• January 2

  • Broad Spectrum Polyphenol Supplementation from Tart Cherry Extract on Markers of Recovery from Intense Resistance Exercise.

    • 2021-01-02
    • RCT
    • Journal of the International Society of Sports Nutrition 18(1)
    • • D R Hooper
      • T Orange
      • M T Gruber
      • A A Darakjian
      • K L Conway
      • H A Hausenblas

    • PubMed: 34126996
    • DOI: 10.1186/s12970-021-00449-x

    6 Insights on

    • Reduced Cardiac Damage
    • Improved Countermovement Jump Power
    • Reduced Muscle Soreness
    • Reduced Oxidative Stress
    • Improved Handgrip Strength
    • Reduced Muscle Damage

    • High evidence
• January 3

  • An Exopolysaccharide Produced by Bifidobacterium longum 35624® Inhibits Osteoclast Formation via a TLR2-Dependent Mechanism

    • 2021-01-03
    • Calcified Tissue International 108(5)
    • • A. Wallimann
      • M. Hildebrand
      • D. Groeger
      • B. Stanić
      • C. Akdis
      • S. Zeiter
      • R. G. Richards
      • T. F. Moriarty
      • L. O’Mahony
      • K. Thompson

    • PubMed: 33388801
    • DOI: 10.1007/s00223-020-00790-4

    3 Insights on

    • Reduced Osteoclast Formation
    • Reduced Bone Loss
    • Increased Mineralized Matrix Deposition

    • Low evidence
    • Rigorous Journal
• January 4

  • Prophylactic effect of Lactobacillus plantarum KSFY06 on HCl/ethanol-induced gastric injury in mice.

    • 2021-01-04
    • Food & Function 11(3)
    • • Ranran Wang
      • Xiaofei Zeng
      • Bihui Liu
      • Ruokun Yi
      • Xianrong Zhou
      • Jianfei Mu
      • Xin Zhao

    • PubMed: 32162630
    • DOI: 10.1039/c9fo02474c

    5 Insights on

    • Enhanced Gastric Protein Protection
    • Reduced Oxidative Stress
    • Reduced Serum Malondialdehyde Levels
    • Reduced Inflammatory Response
    • Reduced Gastric Mucosal Lesion Formation

    • Low evidence

  • A 5-year longitudinal association between dietary fermented soya bean (natto) intake and tooth loss through bone mineral density in postmenopausal women: The Yokogoshi cohort study.

    • 2021-01-04
    • Observational · n = 435
    • Gerodontology 38(3)
    • • M. Iwasaki
      • Misuzu Sato
      • A. Yoshihara
      • Toshiko Saito
      • K. Kitamura
      • T. Ansai
      • Kazutoshi Nakamura

    • PubMed: 33393717
    • DOI: 10.1111/ger.12523

    1 Insight on

    • Reduced Tooth Loss

    • High evidence
• January 5

  • Effects of intragastric administration of L-tryptophan on the glycaemic response to a nutrient drink in men with type 2 diabetes - impacts on gastric emptying, glucoregulatory hormones and glucose absorption.

    • 2021-01-05
    • RCT
    • Nutrition & diabetes 11(1)
    • • Maryam Hajishafiee
      • Rachel A Elovaris
      • Karen L Jones
      • Leonie K Heilbronn
      • Michael Horowitz
      • Sally D Poppitt
      • Christine Feinle-Bisset

    • PubMed: 33414406
    • DOI: 10.1038/s41387-020-00146-9

    11 Insights on

    • Reduced Glucose Absorption
    • Reduced Fasting Blood Glucose Level
    • Increased C-peptide Level
    • Increased Plasma Glucagon Level
    • Reduced Postprandial Glucose Level
    • Reduced Postprandial Glucose
    • Increased Blood Glucose Levels
    • Increased Glucagon Level
    • Slowed Gastric Emptying
    • Reduced Peak Glucose
    • Reduced Fasting Glucose

    • High evidence

  • Exercise associated or not to the intake of Eurycoma longifolia improves strength and cardiorespiratory fitness in men with androgen deficiency.

    • 2021-01-05
    • RCT · n = 12
    • Complementary therapies in clinical practice 42
    • • Alice Erwig Leitão
      • Melissa de Carvalho Souza Vieira
      • Diogo Almeida Gomes
      • Leonessa Boing
      • Andreia Pelegrini
      • Edson Luiz
      • Adriana Coutinho de Azevedo Guimarães

    • PubMed: 33445146
    • DOI: 10.1016/j.ctcp.2020.101301

    3 Insights on

    • Reduced ADAM Symptomatology Score
    • Increased Isokinetic Peak Torque of Knee Flexion
    • Increased Knee Extension Strength

    • High evidence
• January 7

  • Effect of probiotic Lactobacillus plantarum Dad-13 powder consumption on the gut microbiota and intestinal health of overweight adults

    • 2021-01-07
    • RCT · n = 60
    • World Journal of Gastroenterology 27(1)
    • • E. Rahayu
      • M. Mariyatun
      • Nancy Eka Putri Manurung
      • P. N. Hasan
      • Phatthanaphong Therdtatha
      • Riko Mishima
      • Husnita Komalasari
      • N. A. Mahfuzah
      • F. H. Pamungkaningtyas
      • Wahyu Krisna Yoga
      • Dina Aulia Nurfiana
      • Stefanie Yolanda Liwan
      • M. Juffrie
      • A. Nugroho
      • T. Utami

    • PubMed: 33505154
    • DOI: 10.3748/wjg.v27.i1.107

    3 Insights on

    • No Change in Lipid Profile
    • Reduced Body Weight
    • Reduced Body Mass Index

    • High evidence
    • Rigorous Journal

  • The In Vitro Adsorption Ability of Lactobacillus acidophilus NCFM to Benzo(a)pyrene in PM2.5

    • 2021-01-07
    • Journal of Toxicology 2021
    • • L. Fu
      • Y. Ning
      • Hongfei Zhao
      • Junfeng Fan
      • Bolin Zhang

    • PubMed: 33505465
    • DOI: 10.1155/2021/6290524

    1 Insight on

    • Reduced Benzo(a)pyrene Levels

    • Low evidence
    • Rigorous Journal
• January 8

  • Effect of Oral Administration with Lactobacillus plantarum CAM6 Strain on Sows during Gestation-Lactation and the Derived Impact on Their Progeny Performance

    • 2021-01-08
    • RCT · n = 20
    • Mediators of Inflammation 2021
    • • C. Betancur
      • Y. Martínez
      • G. Téllez-Isaías
      • Rogel Castillo
      • Xinghua Ding

    • PubMed: 33505214
    • DOI: 10.1155/2021/6615960

    8 Insights on

    • Improved Milk Composition
    • Improved Physiological Status in Offspring
    • Reduced Offspring Mortality
    • Reduced Diarrhea Incidence
    • Enhanced Lactose Levels in Sows' Milk
    • Increased Birth Weight
    • Reduced Milk Fat Content
    • Reduced Diarrhea Incidence in Offspring

    • Low evidence
    • Rigorous Journal
    • Animal Study
• January 9

  • Interventions for treating leg ulcers in people with sickle cell disease.

    • 2021-01-09
    • Systematic Review · n = 198
    • The Cochrane database of systematic reviews 2021(1)
    • • Arturo J Martí-Carvajal
      • Jennifer M Knight-Madden
      • Maria José Martinez-Zapata

    • PubMed: 34559425
    • DOI: 10.1002/14651858.cd008394.pub4

    2 Insights on

    • Improved Leg Ulcer Healing
    • Reduced Ulcer Size

    • High evidence
• January 11

  • Risk Factors for the Acquisition of Enterococcus faecium Infection and Mortality in Patients with Enterococcal Bacteremia: A 5-Year Retrospective Analysis in a Tertiary Care University Hospital

    • 2021-01-11
    • Observational · n = 186
    • Antibiotics 10(1)
    • • Atsushi Uda
      • K. Shigemura
      • K. Kitagawa
      • Kayo Osawa
      • Kenichiro Onuma
      • Yonmin Yan
      • Tatsuya Nishioka
      • M. Fujisawa
      • I. Yano
      • T. Miyara

    • PubMed: 33440660
    • DOI: 10.3390/antibiotics10010064

    3 Insights on

    • Increased Risk of E. faecium Infection
    • Increased Economic Burden Due to Higher Antibiotic Costs
    • Increased Mortality in Patients with Enterococcal Bacteremia

    • High evidence

  • Investigating the anti‐inflammatory effects of high molecular weight secretions from Limosilactobacillus reuteri PTCC 1655 on LPS‐stimulated PMA‐differentiated THP‐1 cells

    • 2021-01-11
    • Journal of Applied Microbiology 131(2)
    • • Behrooz Johari
      • Faezeh Maghsood
      • H. Madanchi
      • M. Moradi
      • M. Kadivar

    • PubMed: 33377567
    • DOI: 10.1111/jam.14984

    1 Insight on

    • Reduced Inflammation Levels

    • Low evidence
• January 12

  • Impact of 18-Month Soy Protein Supplementation on Steroid Hormones and Serum Biomarkers of Angiogenesis, Apoptosis, and the Growth Hormone/IGF-1 Axis: Results of a Randomized, Placebo-Controlled Trial in Males Following Prostatectomy.

    • 2021-01-12
    • RCT
    • Nutrition and cancer 74(1)
    • • Maarten C Bosland
      • Jonathan Huang
      • Michael J Schlicht
      • Erika Enk
      • Hui Xie
      • Ikuko Kato

    • PubMed: 33432829
    • DOI: 10.1080/01635581.2020.1870706

    17 Insights on

    • Reduced Vascular Endothelial Growth Factor Level
    • Reduced Insulin-Like Growth Factor 1 Level
    • Reduced IGF-1 Level
    • Reduced Sex Hormone-Binding Globulin Level
    • Reduced Fas Ligand Level
    • Reduced Free Testosterone Level
    • Reduced Soluble Fas Ligand Level
    • Reduced Soluble Fas/Fas Ligand Ratio
    • Reduced Vascular Endothelial Growth Factor
    • Reduced Testosterone Level
    • Reduced Insulin-Like Growth Factor-Binding Protein 3 Level
    • Reduced Estradiol Level
    • Reduced Insulin-Like Growth Factor 1 to Insulin-Like Growth Factor Binding Protein 3 Ratio
    • Reduced SHBG
    • Reduced Soluble Fas Level
    • Reduced Soluble Fas to Fas Ligand Ratio
    • Reduced Insulin-like Growth Factor-1/Insulin-like Growth Factor Binding Protein-3 Ratio

    • High evidence

  • Immunomodulation of J774A.1 Murine Macrophages by Lactiplantibacillus plantarum Strains Isolated From the Human Gastrointestinal Tract and Fermented Foods

    • 2021-01-12
    • Frontiers in Microbiology 11
    • • N. Garcia-Gonzalez
      • M. A. Nuñez-Sanchez
      • Miguel Villoria Recio
      • N. Battista
      • C. Gahan
      • A. Corsetti

    • PubMed: 33510712
    • DOI: 10.3389/fmicb.2020.557143

    1 Insight on

    • Modulated Immune Response

    • Low evidence
• January 13

  • Bifidobacterium animalis subsp. lactis BB-12 Improves the State Anxiety and Sports Performance of Young Divers Under Stress Situations: A Single-Arm, Prospective Proof-of-Concept Study.

    • 2021-01-13
    • Clinical Trial
    • Frontiers in psychology 11
    • • Weizhong Dong
      • Ying Wang
      • Shuaixiong Liao
      • Wei Tang
      • Li Peng
      • Gang Song

    • PubMed: 33519585
    • DOI: 10.3389/fpsyg.2020.570298

    3 Insights on

    • Reduced Anxiety
    • Increased Bifidobacteriaceae Abundance
    • Improved Sports Performance

    • Moderate evidence

  • Lactobacillus rhamnosus AD3 as a Promising Alternative for Probiotic Products

    • 2021-01-13
    • Biomolecules 11(1)
    • • A. Stivala
      • G. Carota
      • V. Fuochi
      • P. Furneri

    • PubMed: 33450875
    • DOI: 10.3390/biom11010094

    2 Insights on

    • Reduced Urogenital Pathogen Activity
    • Reduced Risk of Genital Infections

    • Low evidence

  • Effect of Lactobacillus rhamnosus Probiotic in Early Pregnancy on Plasma Conjugated Bile Acids in a Randomised Controlled Trial

    • 2021-01-13
    • RCT · n = 348
    • Nutrients 13(1)
    • • Yutao Chen
      • Jun Lu
      • K. Wickens
      • T. Stanley
      • Robyn M. Maude
      • P. Stone
      • C. Barthow
      • J. Crane
      • E. Mitchell
      • F. Merien
      • R. Murphy

    • PubMed: 33450885
    • DOI: 10.3390/nu13010209

    7 Insights on

    • Decreased Glycocholic Acid Levels in Older Women
    • Reduced Prevalence of Gestational Diabetes Mellitus
    • Reduced Taurodeoxycholic Acid in Women with GDM
    • Reduced Fasting Conjugated Bile Acids
    • Decreased Conjugated Bile Acid Level
    • Reduced Fasting Blood Glucose Levels
    • Reduced Fasting Glucose

    • High evidence
    • Large Human Trial
• January 14

  • Intake of dairy products and associations with major atherosclerotic cardiovascular diseases: a systematic review and meta-analysis of cohort studies.

    • 2021-01-14
    • Meta-Analysis
    • Scientific reports 11(1)
    • • Marianne Uhre Jakobsen
      • Ellen Trolle
      • Malene Outzen
      • Heddie Mejborn
      • Manja G Grønberg
      • Christian Bøge Lyndgaard
      • Anders Stockmarr
      • Stine K Venø
      • Anette Bysted

    • PubMed: 33446728
    • DOI: 10.1038/s41598-020-79708-x

    1 Insight on

    • Reduced Ischemic Stroke

    • High evidence
    • Rigorous Journal

  • Effects of Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 Supplementation on Nutritional and Metabolic Parameters in the Early Postoperative Period after Roux-en-Y Gastric Bypass: a Randomized, Double-Blind, Placebo-Controlled Trial

    • 2021-01-14
    • RCT
    • Obesity Surgery 31(5)
    • • Marília Rizzon Zaparolli Ramos
      • Lígia de Oliveira Carlos
      • Nathalia Ramori Farinha Wagner
      • I. Felicidade
      • Magda Rosa Ramos da Cruz
      • C. Taconeli
      • R. Fernandes
      • A. J. Filho
      • A. Campos

    • PubMed: 33443719
    • DOI: 10.1007/s11695-021-05222-2

    6 Insights on

    • Increased Vitamin B12 Levels
    • Reduced Triglyceride Levels
    • Improved Triglyceride Levels
    • Increased Serum 25-OH Vitamin D Levels
    • Improved Vitamin D Levels
    • Improved Vitamin B12 Levels

    • High evidence
    • Rigorous Journal
• January 15

  • Dietary Supplementation With Bacillus subtilis Promotes Growth and Gut Health of Weaned Piglets

    • 2021-01-15
    • RCT · n = 160
    • Frontiers in Veterinary Science 7
    • • Zhilong Tian
      • Xiaodan Wang
      • Y. Duan
      • Yue Zhao
      • Wenming Zhang
      • M. Azad
      • Zhanbin Wang
      • F. Blachier
      • X. Kong

    • PubMed: 33521080
    • DOI: 10.3389/fvets.2020.600772

    8 Insights on

    • Increased Body Weight
    • Improved Intestinal Morphology
    • Improved Growth Performance
    • Improved Gut Microbiota Composition
    • Enhanced Metabolic Pathway Function
    • Improved Gastrointestinal Health
    • Reduced Diarrhea Incidence
    • Reduced Diarrhea Rate

    • Low evidence
    • Animal Study
• January 16

  • The efficacy and safety of Serenoa repens extract for the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome: a multicenter, randomized, double-blind, placebo-controlled trial.

    • 2021-01-16
    • RCT · n = 226
    • World journal of urology 39(9)
    • • Kai Zhang
      • Run-Qi Guo
      • Shan-Wen Chen
      • Bin Chen
      • Xin-Bo Xue
      • Shan Chen
      • Jian Huang
      • Ming Liu
      • Ye Tian
      • Li Zuo
      • Ming Chen
      • Li-Qun Zhou

    • PubMed: 33452912
    • DOI: 10.1007/s00345-020-03577-2

    5 Insights on

    • Improved Erectile Function
    • Increased Clinical Response Rate
    • Improved Chronic Prostatitis Symptom Index Quality of Life Score
    • Improved Chronic Prostatitis Symptom Index Score
    • Improved Chronic Prostatitis Urinary Symptoms

    • High evidence
    • Large Human Trial
• January 19

  • Modulation of the immune response and metabolism in germ-free rats colonized by the probiotic Lactobacillus salivarius LI01

    • 2021-01-19
    • Clinical Trial · n = 2
    • Applied Microbiology and Biotechnology 105(4)
    • • Jiafeng Xia
      • Shiman Jiang
      • L. Lv
      • Wen-rui Wu
      • Qiangqiang Wang
      • Qiaomai Xu
      • Jianzhong Ye
      • D. Fang
      • Yating Li
      • Jingjing Wu
      • Xiaoyuan Bian
      • Liya Yang
      • Huiyong Jiang
      • Kaicen Wang
      • Ren Yan
      • Lanjuan Li

    • PubMed: 33507355
    • DOI: 10.1007/s00253-021-11099-z

    11 Insights on

    • Increased Body Weight
    • Improved Metabolic Regulation
    • Improved Serum Biomarkers
    • Enhanced Immune Response
    • Improved Arginine Metabolism
    • Enhanced Metabolic Function
    • Improved Immune Homeostasis
    • Increased Energy Levels
    • Improved Energy Metabolism
    • Modulated Immune Response
    • Increased Levels of Indole-3-Lactic Acid

    • Low evidence
    • Animal Study

  • The Probiotic Lactobacillus fermentum Biocenol CCM 7514 Moderates Campylobacter jejuni-Induced Body Weight Impairment by Improving Gut Morphometry and Regulating Cecal Cytokine Abundance in Broiler Chickens

    • 2021-01-19
    • RCT · n = 72
    • Animals 11(1)
    • • M. Šefcová
      • Marco Larrea-Álvarez
      • C. Larrea-Álvarez
      • V. Karaffová
      • D. Ortega-Paredes
      • Christian Vinueza-Burgos
      • Z. Ševčíková
      • M. Levkut
      • R. Herich
      • V. Révajová

    • PubMed: 33477806
    • DOI: 10.3390/ani11010235

    3 Insights on

    • Enhanced Cytokine Response
    • Improved Intestinal Morphometry
    • Improved Body Weight

    • Low evidence
    • Rigorous Journal
    • Animal Study
• January 21

  • Cissus Quadrangularis enhances UCP1 mRNA, indicative of white adipocyte browning and decreases central obesity in humans in a randomized trial.

    • 2021-01-21
    • RCT
    • Scientific reports 11(1)
    • • Saimai Chatree
      • Chantacha Sitticharoon
      • Pailin Maikaew
      • Kitchaya Pongwattanapakin
      • Issarawan Keadkraichaiwat
      • Malika Churintaraphan
      • Chanakarn Sripong
      • Rungnapa Sririwichitchai
      • Sompol Tapechum

    • PubMed: 33479386
    • DOI: 10.1038/s41598-021-81606-9

    3 Insights on

    • Increased Leptin Levels
    • Reduced Hip Circumference
    • Reduced Waist Circumference

    • High evidence
    • Rigorous Journal

  • Effect of Microencapsulation on Survival at Simulated Gastrointestinal Conditions and Heat Treatment of a Non Probiotic Strain, Lactiplantibacillus plantarum 48M, and the Probiotic Strain Limosilactobacillus reuteri DSM 17938

    • 2021-01-21
    • Foods 10(2)
    • • C. Malmo
      • I. Giordano
      • G. Mauriello

    • PubMed: 33494235
    • DOI: 10.3390/foods10020217

    1 Insight on

    • Improved Gut Microbial Persistence

    • Low evidence
    • Rigorous Journal
• January 22

  • Does Vancomycin Resistance Increase Mortality? Clinical Outcomes and Predictive Factors for Mortality in Patients with Enterococcus faecium Infections

    • 2021-01-22
    • Observational · n = 145
    • Antibiotics 10(2)
    • • Jatapat Hemapanpairoa
      • Dhitiwat Changpradub
      • S. Thunyaharn
      • W. Santimaleeworagun

    • PubMed: 33499102
    • DOI: 10.3390/antibiotics10020105

    2 Insights on

    • Increased Length of Hospitalization Due to Vancomycin Resistance
    • Increased Mortality Rate with Vancomycin Resistance

    • High evidence
• January 23

  • Protocol for probiotic therapy vs placebo for preterm prelabour rupture of membranes to prolong pregnancy duration (Pro-PPROM) trial.

    • 2021-01-23
    • RCT
    • The Australian & New Zealand journal of obstetrics & gynaecology 61(2)
    • • Jonathan Sandeford
      • Tanya Nippita
      • Tushar Bhuta
      • Jillian Patterson
      • Jonathan Morris
      • Sean Seeho

    • PubMed: 33484479
    • DOI: 10.1111/ajo.13313

    1 Insight on

    • Prolonged Pregnancy Duration

    • High evidence
• January 24

  • Wheat-durum pasta added of inactivated Bifidobacterium animalis decreases glucose and total cholesterol levels and modulates gut microbiota in healthy rats

    • 2021-01-24
    • RCT · n = 21
    • International Journal of Food Sciences and Nutrition 72(6)
    • • C. N. Almada
      • Carine N. Almada-Érix
      • Whyara K A Costa
      • Juliana Silva
      • Lucélia Cabral
      • M. F. Noronha
      • A. E. S. S. Gonçalves
      • Andrey Santos
      • P. Lollo
      • M. Magnani
      • A. Sant’Ana

    • PubMed: 33487082
    • DOI: 10.1080/09637486.2021.1877261

    5 Insights on

    • Reduced Serum Total Cholesterol Levels
    • Reduced Serum Glucose Levels
    • Enhanced Beneficial Gut Microbiota
    • Lower Plasma Glucose Levels
    • Reduced Total Cholesterol Levels

    • Low evidence
    • Animal Study

  • Lactobacillus Plantarum 299v Changes miRNA Expression in the Intestines of Piglets and Leads to Downregulation of LITAF by Regulating ssc-miR-450a.

    • 2021-01-24
    • Probiotics and antimicrobial proteins 13(4)
    • • Qi Wang
      • Qian Sun
      • Jing Wang
      • Xiaoyu Qiu
      • Renli Qi
      • Jinxiu Huang

    • PubMed: 33486700
    • DOI: 10.1007/s12602-021-09743-1

    2 Insights on

    • Reduced Intestinal Proinflammatory Cytokine Levels
    • Improved Intestinal Cytokine Function

    • Low evidence
    • Rigorous Journal
    • Animal Study
• January 25

  • Probiotic Lactobacillus casei Shirota prevents acute liver injury by reshaping the gut microbiota to alleviate excessive inflammation and metabolic disorders

    • 2021-01-25
    • RCT
    • Microbial Biotechnology 15(1)
    • • Ren Yan
      • Kaicen Wang
      • Qiangqiang Wang
      • Huiyong Jiang
      • Ying-feng Lu
      • Xiaoxiao Chen
      • Hua Zhang
      • Xiaoling Su
      • Yiling Du
      • Lifeng Chen
      • Lanjuan Li
      • L. Lv

    • PubMed: 33492728
    • DOI: 10.1111/1751-7915.13750

    4 Insights on

    • Altered Circulating Metabolic Profile
    • Reduced Liver Biochemical Markers
    • Modulated Liver Metabolic Pathways
    • Reduced Pro-inflammatory Cytokine Levels

    • Low evidence
    • Animal Study

  • The role of Lactobacillus plantarum 299v in supporting treatment of selected diseases.

    • 2021-01-25
    • Review
    • Central-European journal of immunology 45(4)
    • • Karolina Kaźmierczak-Siedlecka
      • Agnieszka Daca
      • Marcin Folwarski
      • Jacek M Witkowski
      • Ewa Bryl
      • Wojciech Makarewicz

    • PubMed: 33613097
    • DOI: 10.5114/ceji.2020.101515

    11 Insights on

    • Reduced Cancer-Related Inflammation
    • Reduced Risk of Clostridium Difficile-Associated Diarrhea
    • Reduced Diarrhea Incidence
    • Improved Gastrointestinal Microbiome Balance
    • Reduced Cancer Risk
    • Improved Gut Microbiota Composition
    • Reduced Inflammation
    • Improved Irritable Bowel Syndrome Symptoms
    • Reduced Abdominal Pain
    • Reduced Irritable Bowel Syndrome Symptoms
    • Reduced Diarrhea Rate

    • Low evidence

  • Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review.

    • 2021-01-25
    • Systematic Review · n = 327
    • BMJ open 11(1)
    • • Jimmy de Oliveira Araújo
      • Cristiane de Cássia Bergamaschi
      • Luciane Cruz Lopes
      • Caio Chaves Guimarães
      • Natalia Karol de Andrade
      • Juliana Cama Ramacciato
      • Rogério Heládio Lopes Motta

    • PubMed: 33495257
    • DOI: 10.1136/bmjopen-2020-043363

    3 Insights on

    • Reduced Heart Rate
    • Reduced Anxiety
    • Reduced Blood Pressure

    • High evidence

  • Functional characterization and immunomodulatory properties of Lactobacillus helveticus strains isolated from Italian hard cheeses

    • 2021-01-25
    • PLOS ONE 16(1)
    • • M. Zago
      • L. Massimiliano
      • B. Bonvini
      • G. Penna
      • G. Giraffa
      • M. Rescigno

    • PubMed: 33493208
    • DOI: 10.1371/journal.pone.0245903

    9 Insights on

    • Gastrointestinal Survival
    • Increased IL-10 Levels
    • Increased Anti-Inflammatory Cytokine Levels
    • Increased Pro-inflammatory Cytokine Release
    • Enhanced Anti-inflammatory Properties
    • Modulated Immune Response
    • Reduced IL-12p70 Release
    • Reduced Pro-inflammatory Cytokine Release
    • Reduced Inflammation Levels

    • Low evidence
    • Rigorous Journal

  • The Acid-Dependent and Independent Effects of Lactobacillus acidophilus CL1285, Lacticaseibacillus casei LBC80R, and Lacticaseibacillus rhamnosus CLR2 on Clostridioides difficile R20291

    • 2021-01-25
    • Probiotics and Antimicrobial Proteins 13(4)
    • • Sathursha Gunaratnam
      • C. Diarra
      • Patrick D. Paquette
      • N. Ship
      • M. Millette
      • M. Lacroix

    • PubMed: 33492661
    • DOI: 10.1007/s12602-020-09729-5

    2 Insights on

    • Reduced Risk of Clostridium Difficile-Associated Diarrhea
    • Neutralized Toxins

    • Low evidence
• January 27

  • Lactobacillus Kefiri LKF01 (Kefibios®) for Prevention of Diarrhoea in Cancer Patients Treated with Chemotherapy: A Prospective Study

    • 2021-01-27
    • Observational · n = 76
    • Nutrients 13(2)
    • • M. Ghidini
      • M. Nicoletti
      • M. Ratti
      • G. Tomasello
      • V. Lonati
      • M. Ghilardi
      • M. Parati
      • K. Borgonovo
      • M. Cabiddu
      • F. Petrelli

    • PubMed: 33513713
    • DOI: 10.3390/nu13020385

    2 Insights on

    • Reduced Incidence of Severe Diarrhoea
    • Reduced Chemotherapy-Induced Diarrhea

    • High evidence
• January 28

  • A clinical pilot study on the effect of the probiotic Lacticaseibacillus rhamnosus TOM 22.8 strain in women with vaginal dysbiosis

    • 2021-01-28
    • Scientific Reports 11(1)
    • • A. Pino
      • A. Rapisarda
      • S. Vitale
      • S. Cianci
      • C. Caggia
      • C. Randazzo
      • A. Cianci

    • PubMed: 33510271
    • DOI: 10.1038/s41598-021-81931-z

    5 Insights on

    • Reduced Pathogenic Load
    • Reduced Vaginal Pathogens
    • Increased Antioxidant Activity
    • Reduced Inflammation Levels
    • Maintained Vaginal Eubiosis

    • Low evidence
    • Rigorous Journal

  • Probiotics, Anticipation Stress, and the Acute Immune Response to Night Shift.

    • 2021-01-28
    • RCT · n = 29
    • Frontiers in immunology 11
    • • Nicholas P West
      • Lily Hughes
      • Rebecca Ramsey
      • Ping Zhang
      • Ping Zhang
      • Christopher J Martoni
      • Gregory J Leyer
      • Allan W Cripps
      • Amanda J Cox

    • PubMed: 33584665
    • DOI: 10.3389/fimmu.2020.599547

    12 Insights on

    • Reduced E-Selectin-1 Level
    • Reduced Pentraxin Level
    • Reduced Cortisol Levels
    • Reduced MAdCAM-1 Level
    • Reduced Interleukin-10 Levels
    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Erythrocyte Sedimentation Rate
    • Reduced C-Reactive Protein Levels
    • Reduced Interleukin-1 Beta Level
    • Improved Sleep Quality
    • Increased Interleukin-1 Receptor Antagonist Level
    • Reduced Interleukin-6 Levels

    • High evidence

  • Interactions of Oxysterols with Atherosclerosis Biomarkers in Subjects with Moderate Hypercholesterolemia and Effects of a Nutraceutical Combination (Bifidobacterium longum BB536, Red Yeast Rice Extract) (Randomized, Double-Blind, Placebo-Controlled Study).

    • 2021-01-28
    • RCT
    • Nutrients 13(2)
    • • Stefania Cicolari
      • Chiara Pavanello
      • Elena Olmastroni
      • Marina Del Puppo
      • Marco Bertolotti
      • Giuliana Mombelli
      • Alberico L Catapano
      • Laura Calabresi
      • Paolo Magni

    • PubMed: 33525601
    • DOI: 10.3390/nu13020427

    6 Insights on

    • Reduced 27-Hydroxycholesterol Level
    • Reduced 24-Hydroxycholesterol to Total Cholesterol Ratio
    • Reduced 27-Hydroxycholesterol to Total Cholesterol Ratio
    • Reduced 25-Hydroxycholesterol Level
    • Reduced 25-Hydroxycholesterol to Total Cholesterol Ratio
    • Reduced Total Cholesterol Levels

    • High evidence
    • Rigorous Journal
• January 29

  • Co-ingestion of NUTRALYS® pea protein and a high-carbohydrate beverage influences the glycaemic, insulinaemic, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) responses: preliminary results of a randomised controlled trial.

    • 2021-01-29
    • RCT
    • European journal of nutrition 60(6)
    • • Pariyarath Sangeetha Thondre
      • Ifunanya Achebe
      • Alistair Sampson
      • Tyler Maher
      • Laetitia Guérin-Deremaux
      • Catherine Lefranc-Millot
      • Elisabeth Ahlström
      • Helen Lightowler

    • PubMed: 33515092
    • DOI: 10.1007/s00394-021-02481-8

    2 Insights on

    • Increased Insulin Secretion
    • Reduced Postprandial Glucose

    • High evidence
    • Rigorous Journal

  • Effect of Lactobacillus casei on lipid metabolism and intestinal microflora in patients with alcoholic liver injury

    • 2021-01-29
    • RCT
    • European Journal of Clinical Nutrition 75(8)
    • • Xuelong Li
      • Ying Liu
      • Xiaofei Guo
      • Yan Ma
      • Huaqi Zhang
      • Hui Liang

    • PubMed: 33514869
    • DOI: 10.1038/s41430-020-00852-8

    2 Insights on

    • Improved Intestinal Microflora Balance
    • Improved Lipid Metabolism

    • High evidence
• Undated – 17 supplement studies

  • Bifidobacterium longum counters the effects of obesity: Partial successful translation from rodent to human

    • 2021-01
    • RCT
    • EBioMedicine 63
    • • H. Schellekens
      • C. Torres-Fuentes
      • M. van de Wouw
      • C. Long-Smith
      • A. Mitchell
      • C. Strain
      • K. Berding
      • T. Bastiaanssen
      • K. Rea
      • A. Golubeva
      • S. Arboleya
      • Mathieu Verpaalen
      • M. Pusceddu
      • A. Murphy
      • F. Fouhy
      • K. Murphy
      • P. Ross
      • Bernard L. Roy
      • C. Stanton
      • T. Dinan
      • J. Cryan

    • PubMed: 33349590
    • DOI: 10.1016/j.ebiom.2020.103176

    13 Insights on

    • Reduced Serum Glucose Levels
    • Improved Glucose Tolerance
    • Reduced Body Weight
    • Reduced Fasting Blood Sugar Levels
    • Improved Blood Glucose Levels
    • Reduced Body Mass Index
    • Reduced Fat Depots Accumulation
    • Unchanged Waist-to-Hip Ratio
    • Stable Body-Mass Index (BMI)
    • Improved Waist-to-Hip Ratio
    • Reduced Hepatic Fat Accumulation
    • Reduced Fasting Blood Glucose Levels
    • Change in Waist-to-Hip Ratio

    • High evidence
    • Rigorous Journal

  • Effect of long-term dietary probiotic Lactobacillus reuteri 1 or antibiotics on meat quality, muscular amino acids and fatty acids in pigs.

    • 2021-01
    • Clinical Trial
    • Meat Science 171
    • • Z. Tian
      • Yiyan Cui
      • Huijie Lu
      • Gang Wang
      • Xianyong Ma

    • PubMed: 32906013
    • DOI: 10.1016/j.meatsci.2020.108234

    3 Insights on

    • Enhanced Protein Synthesis
    • Reduced Drip Loss
    • Altered Fatty Acid Profiles

    • Low evidence
    • Animal Study

  • Potential mechanisms underlying the ameliorative effect of Lactobacillus paracasei FZU103 on the lipid metabolism in hyperlipidemic mice fed a high-fat diet.

    • 2021-01
    • Clinical Trial
    • Food Research International 139
    • • Xu-Cong Lv
      • Min Chen
      • Zi-Rui Huang
      • Wei-ling Guo
      • Lian-zhong Ai
      • Weidong Bai
      • Xiao-Dan Yu
      • Ying-Li Liu
      • P. Rao
      • Li Ni

    • PubMed: 33509508
    • DOI: 10.1016/j.foodres.2020.109956

    10 Insights on

    • Reduced Adipocyte Hypertrophy
    • Improved Gut Microbiome Composition
    • Reduced Body Weight
    • Reduced Hepatic Lipid Accumulation
    • Stable Body Weight
    • Reduced Weight Gain
    • Increased Bile Acid Excretion
    • Reduced Hepatic Fat Accumulation
    • Improved Lipid Metabolism
    • Improved Liver Metabolic Pathways

    • Low evidence
    • Animal Study

  • Lactobacillus reuteri DSM 17938 alleviates d-galactosamine-induced liver failure in rats.

    • 2021-01
    • Clinical Trial
    • Biomedicine & Pharmacotherapy 133
    • • Huiyong Jiang
      • Ren Yan
      • Kaicen Wang
      • Qiangqiang Wang
      • Xiaoxiao Chen
      • Lifeng Chen
      • Lanjuan Li
      • L. Lv

    • PubMed: 33202285
    • DOI: 10.1016/j.biopha.2020.111000

    7 Insights on

    • Reduced Fecal Metabolite Levels
    • Reduced Proinflammatory Signaling
    • Improved Intestinal Histology
    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Pathogenic Bacteria Levels
    • Reduced Liver Injury
    • Improved Liver Function

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Probiotic-Derived Polyphosphate Accelerates Intestinal Epithelia Wound Healing through Inducing Platelet-Derived Mediators.

    • 2021-01
    • Mediators of inflammation 2021(1)
    • • Shotaro Isozaki
      • Hiroaki Konishi
      • Mikihiro Fujiya
      • Hiroki Tanaka
      • Yuki Murakami
      • Shin Kashima
      • Katsuyoshi Ando
      • Nobuhiro Ueno
      • Kentaro Moriichi
      • Toshikatsu Okumura

    • PubMed: 33859537
    • DOI: 10.1155/2021/5582943

    3 Insights on

    • Accelerated Wound Healing
    • Improved Intestinal Barrier Function
    • Improved Wound Healing

    • Low evidence
    • Animal Study

  • The Possible Role of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson's Disease.

    • 2021-01
    • Oxidative medicine and cellular longevity 2021(1)
    • • Ovidiu-Dumitru Ilie
      • Emanuela Paduraru
      • Madalina-Andreea Robea
      • Ioana-Miruna Balmus
      • Roxana Jijie
      • Mircea Nicoara
      • Alin Ciobica
      • Ilinca-Bianca Nita
      • Romeo Dobrin
      • Bogdan Doroftei

    • PubMed: 34691361
    • DOI: 10.1155/2021/9629102

    3 Insights on

    • No Significant Improvement in Locomotor Activity
    • Reduced Lipid Peroxidation
    • No Change in Oxidative Stress Markers

    • Low evidence

  • Oral administration of Bifidobacterium breve promotes antitumor efficacy via dendritic cells-derived interleukin 12

    • 2021-01
    • Clinical Trial
    • OncoImmunology 10(1)
    • • Qingxiang Li
      • Yuke Li
      • Yifei Wang
      • Le Xu
      • Yuxing Guo
      • Yixiang Wang
      • Lin Wang
      • Chuanbin Guo

    • PubMed: 33537172
    • DOI: 10.1080/2162402X.2020.1868122

    4 Insights on

    • Improved Gut Microbiota
    • Increased Interleukin 12 Secretion from Dendritic Cells
    • Enhanced Dendritic Cell Recruitment in Intestinal Villi
    • Reduced Tumor Growth

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Immuno-modulation by heat-killed Lacticaseibacillus paracasei MCC1849 and its application to food products

    • 2021-01
    • International Journal of Immunopathology and Pharmacology 35
    • • Hazuki Maehata
      • S. Arai
      • N. Iwabuchi
      • F. Abe

    • PubMed: 33787390
    • DOI: 10.1177/20587384211008291

    1 Insight on

    • Modulated Immune Response

    • Low evidence
    • Rigorous Journal

  • Rice flour fermented with Lactobacillus paracasei CBA L74 in the treatment of atopic dermatitis in infants: A randomized, double- blind, placebo- controlled trial.

    • 2021-01
    • RCT
    • Pharmacological Research 163
    • • E. D’Auria
      • S. Panelli
      • L. Lunardon
      • M. Pajoro
      • L. Paradiso
      • S. Beretta
      • C. Loretelli
      • D. Tosi
      • Matteo Perini
      • G. Bedogni
      • A. Abdelsalam
      • P. Fiorina
      • C. Bandi
      • G. Zuccotti

    • PubMed: 33157233
    • DOI: 10.1016/j.phrs.2020.105284

    13 Insights on

    • No Significant Reduction in Atopic Dermatitis Severity
    • Reduced Topical Steroid Usage
    • Improved SCORAD Index
    • Reduced Atopic Dermatitis Severity
    • No Change in Cytokine Levels
    • Regulated Cytokine Levels
    • Improved Atopic Dermatitis Severity
    • No Reduction in Atopic Dermatitis Severity
    • Reduced Corticosteroid Usage
    • Enhanced Gut Microbiota Stability
    • Reduced SCORAD Index
    • Stabilized Cytokine Levels
    • Reduced Steroid Usage

    • High evidence
    • Rigorous Journal

  • Probiotic Pediococcus acidilactici strain from tomato pickle displays anti-cancer activity and alleviates gut inflammation in-vitro

    • 2021-01
    • 3 Biotech 11(1)
    • • Anuradha Barigela
      • Bhima Bhukya

    • PubMed: 33442521
    • DOI: 10.1007/s13205-020-02570-1

    1 Insight on

    • Reduced Cancer Activity

    • Low evidence

  • Fewer Community-Acquired Colds with Daily Consumption of Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2. A Randomized, Placebo-Controlled Clinical Trial

    • 2021-01
    • RCT · n = 898
    • The Journal of Nutrition 151(1)
    • • I. L. Ahrén
      • M. Hillman
      • E. Nordström
      • N. Larsson
      • T. Niskanen

    • PubMed: 33296464
    • DOI: 10.1093/jn/nxaa353

    11 Insights on

    • Improved IFN-γ Levels
    • Altered IFN-γ Levels
    • Reduced Incidence of Community-Acquired Colds
    • Reduced Cold Incidence
    • Modulated Immune Marker IFN-γ
    • Reduced Frequency of Recurring Colds
    • Reduced Incidence of Colds
    • Reduced Incidence of Common Cold
    • Reduced Cold Recurrence
    • Reduced Analgesic Usage
    • Reduced Incidence of Recurring Colds

    • High evidence
    • Large Human Trial

  • Effect of 8 weeks' supplementation grape seed extract on insulin resistance in iranian adolescents with metabolic syndrome: A randomized controlled trial.

    • 2021-01
    • RCT · n = 24
    • Diabetes & metabolic syndrome 15(1)
    • • Alizadeh Mohammad
      • Taghizadeh Shahnaz
      • Kheirouri Sorayya

    • PubMed: 33385766
    • DOI: 10.1016/j.dsx.2020.12.028

    7 Insights on

    • Improved Blood Lipid Profile
    • Improved Insulin Sensitivity
    • Improved Insulin Levels
    • Reduced Body Weight
    • Reduced Fasting Blood Glucose Levels
    • Reduced Waist Circumference
    • Reduced Blood Pressure

    • High evidence

  • Effect of active dry yeast on lactation performance, methane production, and ruminal fermentation patterns in early-lactating Holstein cows.

    • 2021-01
    • RCT · n = 60
    • Journal of Dairy Science 104(1)
    • • Yan Li
      • Yizhao Shen
      • J. Niu
      • Yanfei Guo
      • Mirielle L Pauline
      • Xiaojing Zhao
      • Qiufeng Li
      • Yufeng Cao
      • Chongliang Bi
      • Xiujiang Zhang
      • Zhonghua Wang
      • Yanxia Gao
      • Jianguo Li

    • PubMed: 33272580
    • DOI: 10.3168/jds.2020-18594

    4 Insights on

    • Reduced Methane Production
    • Reduced Somatic Cell Count
    • Improved Lactation Performance
    • Improved Digestibility

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Effect of fermented milk on upper respiratory tract infection in adults who lived in the haze area of Northern China: a randomized clinical trial.

    • 2021-01
    • RCT · n = 136
    • Pharmaceutical biology 59(1)
    • • Hong Zhang
      • Junli Miao
      • Miya Su
      • Bryan Y Liu
      • Zhenmin Liu

    • PubMed: 34062085
    • DOI: 10.1080/13880209.2021.1929344

    6 Insights on

    • Increased Secretory Immunoglobulin A Level
    • Reduced Severity of Upper Respiratory Tract Infection
    • Reduced Incidence of Common Cold
    • Reduced Influenza-like Illness Incidence
    • Reduced Upper Respiratory Infections
    • Increased Interferon-Gamma Levels

    • High evidence
    • Large Human Trial

  • Efficacy of L-Carnitine for Dilated Cardiomyopathy: A Meta-Analysis of Randomized Controlled Trials.

    • 2021-01
    • Meta-Analysis · n = 23
    • BioMed research international 2021(1)
    • • Yayun Weng
      • Shuo Zhang
      • Wei Huang
      • Xianze Xie
      • Zhiyuan Ma
      • Qiaomei Fan

    • PubMed: 33521132
    • DOI: 10.1155/2021/9491615

    6 Insights on

    • Improved Cardiac Output
    • Reduced Brain Natriuretic Peptide Level
    • Reduced Left Ventricular End-Diastolic Dimension
    • Improved Therapeutic Efficacy
    • Improved Left Ventricular Ejection Fraction
    • Increased Transforming Growth Factor-β Levels

    • High evidence

  • Effect of supplementation of a dairy-originated probiotic bacterium, Propionibacterium freudenreichii subsp. freudenreichii, on the cecal microbiome of turkeys challenged with multidrug-resistant Salmonella Heidelberg1

    • 2021-01
    • RCT
    • Poultry Science 100(1)
    • • Divek V. T. Nair
      • T. Johnson
      • S. Noll
      • A. Kollanoor Johny

    • PubMed: 33357692
    • DOI: 10.1016/j.psj.2020.09.091

    2 Insights on

    • Reduced Multidrug-Resistant Salmonella Heidelberg Colonization
    • Reduced Inflammatory Response

    • High evidence
    • Rigorous Journal

  • Effect of feeding Bacillus subtilis on rumen fermentation, blood metabolites, nutrient digestibility, and energy and nitrogen balances in non-lactating crossbred cows.

    • 2021-01
    • RCT · n = 4
    • Animal Science Journal 92(1)
    • • Daisuke Kawauchi
      • W. Angthong
      • O. Keaokliang
      • T. Ishida
      • Toshihiro Takahashi
      • T. Kawashima

    • PubMed: 33638258
    • DOI: 10.1111/asj.13531

    2 Insights on

    • Reduced Plasma Non-Esterified Fatty Acid Concentrations
    • Increased Heat Production

    • Low evidence
    • Animal Study