September 2024 Supplement Research Papers

• September 4

  • The hepatorenal protective effects of silymarin in cancer patients receiving chemotherapy: a randomized, placebo-controlled trial.

    • 2024-09-04
    • RCT · n = 100
    • BMC complementary medicine and therapies 24(1)
    • • Safoora Sadat Erfanian
      • Hourieh Ansari
      • Shaghayegh Haghjooy Javanmard
      • Zahra Amini
      • Ali Hajigholami

    • PubMed: 39232773
    • DOI: 10.1186/s12906-024-04627-7

    4 Insights on

    • Reduced Blood Urea Nitrogen Levels
    • Reduced Alkaline Phosphatase Level
    • Reduced Creatinine Level
    • Reduced Bilirubin

    • High evidence
    • Large Human Trial
• September 5

  • Antidiabetic potential of fenugreek (Trigonella foenum-graecum): A magic herb for diabetes mellitus.

    • 2024-09-05
    • Review
    • Food science & nutrition 12(10)
    • • Dipto Kumer Sarker
      • Pallobi Ray
      • Ashit Kumar Dutta
      • Razina Rouf
      • Shaikh Jamal Uddin

    • PubMed: 39479631
    • DOI: 10.1002/fsn3.4440

    3 Insights on

    • Improved Insulin Sensitivity
    • Improved Blood Glucose Levels
    • Improved Blood Lipid Profile

    • Low evidence
• September 6

  • Probiotics for the prevention of gestational diabetes mellitus: A meta-analysis of randomized controlled trials.

    • 2024-09-06
    • Meta-Analysis
    • Biomolecules & biomedicine 24(5)
    • • Xue Li
      • Luwen Zhang
      • Yuanqi He
      • Dandan Zhang
      • Shihong Zhang

    • PubMed: 38642385
    • DOI: 10.17305/bb.2024.10377

    1 Insight on

    • Reduced Prevalence of Gestational Diabetes Mellitus

    • High evidence

  • Efficacy and safety of berberine plus 5-ASA for ulcerative colitis: A systematic review and meta-analysis.

    • 2024-09-06
    • Meta-Analysis · n = 952
    • PloS one 19(9)
    • • Jilei Li
      • Chenchen Zhang
      • Yanchao Xu
      • Lili Yang

    • PubMed: 39241013
    • DOI: 10.1371/journal.pone.0309144

    6 Insights on

    • Reduced Inflammatory Markers
    • Improved Immune Modulation
    • Reduced Disease Activity Index Scores
    • Improved Clinical Efficacy Rate
    • Reduced Baron Score
    • Reduced Symptom Relief Latency

    • High evidence
• September 7

  • Integrated gut microbiome and metabolome analyses identified fecal biomarkers for bowel movement regulation by Bifidobacterium longum BB536 supplementation: A RCT.

    • 2024-09-07
    • RCT · n = 24
    • Computational and structural biotechnology journal 20
    • • Yuya Nakamura
      • Shinya Suzuki
      • Shinnosuke Murakami
      • Yuichiro Nishimoto
      • Koichi Higashi
      • Naoki Watarai
      • Junpei Umetsu
      • Chiharu Ishii
      • Yutaro Ito
      • Yuka Mori
      • Mamiko Kohno
      • Takuji Yamada
      • Shinji Fukuda

    • PubMed: 36382178
    • DOI: 10.1016/j.csbj.2022.10.026

    1 Insight on

    • Improved Bowel Movement Frequency

    • High evidence
• September 12

  • The human microbiome in space: parallels between Earth-based dysbiosis, implications for long-duration spaceflight, and possible mitigation strategies.

    • 2024-09-12
    • Review
    • Clinical microbiology reviews 37(3)
    • • Sofia Etlin
      • Julianna Rose
      • Luca Bielski
      • Claire Walter
      • Ashley S Kleinman
      • Christopher E Mason

    • PubMed: 39136453
    • DOI: 10.1128/cmr.00163-22

    3 Insights on

    • Improved Sleep Quality
    • Reduced Fatigue
    • Reduced Stress-Related Discomfort

    • Low evidence
• September 13

  • Microbiota-targeted interventions and clinical implications for maternal-offspring health: An umbrella review of systematic reviews and meta-analyses of randomised controlled trials.

    • 2024-09-13
    • Systematic Review · n = 915
    • Journal of global health 14
    • • Bekalu Kassie Alemu
      • Ling Wu
      • Getnet Gedefaw Azeze
      • So Ling Lau
      • Yao Wang
      • Chi Chiu Wang

    • PubMed: 39269153
    • DOI: 10.7189/jogh.14.04177

    9 Insights on

    • Reduced Depression Symptoms
    • Improved Lipid Metabolism
    • Reduced Anxiety
    • Reduced Prevalence of Gestational Diabetes Mellitus
    • Improved Glycemia
    • Improved Infant Gut Microbiome Development
    • Reduced Mastitis Risk
    • Reduced Rectovaginal Bacterial Colonization
    • Reduced Infant Allergies

    • High evidence
• September 14

  • Functional Muffins Exert Bifidogenic Effects along with Highly Product-Specific Effects on the Human Gut Microbiota Ex Vivo.

    • 2024-09-14
    • n = 3
    • Metabolites 14(9)
    • • Stef Deyaert
      • Jonas Poppe
      • Lam Dai Vu
      • Aurélien Baudot
      • Sarah Bubeck
      • Thomas Bayne
      • Kiran Krishnan
      • Morgan Giusto
      • Samuel Moltz
      • Pieter Van den Abbeele

    • PubMed: 39330504
    • DOI: 10.3390/metabo14090497

    3 Insights on

    • Improved Gut Microbiota Composition
    • Increased Short-Chain Fatty Acid Production
    • Reduced Clostridioides difficile Abundance

    • Low evidence
• September 15

  • Nutraceutical interventions for erectile dysfunction: a systematic review and network meta-analysis.

    • 2024-09-15
    • Systematic Review · n = 1,000
    • The journal of sexual medicine 21(11)
    • • Arcangelo Barbonetti
      • Daniele Tienforti
      • Federica Antolini
      • Luca Spagnolo
      • Francesca Cavallo
      • Alfonso Boris Di Pasquale
      • Mario Maggi
      • Giovanni Corona

    • PubMed: 39279185
    • DOI: 10.1093/jsxmed/qdae123

    1 Insight on

    • Improved Erectile Function

    • High evidence
• September 16

  • Effects of chia seed (Salvia hispanica L.) supplementation on cardiometabolic health in overweight subjects: a systematic review and meta-analysis of RCTs.

    • 2024-09-16
    • Review
    • Nutrition & metabolism 21(1)
    • • Mehdi Karimi
      • Samira Pirzad
      • Niyousha Shirsalimi
      • Sajad Ahmadizad
      • Seyyed Mohammad Hashemi
      • Seyyed Mohammad Hashemi
      • Shaghayegh Karami
      • Kimia Kazemi
      • Erfan Shahir-Roudi
      • Anita Aminzadeh

    • PubMed: 39285289
    • DOI: 10.1186/s12986-024-00847-3

    1 Insight on

    • Reduced Waist Circumference

    • Low evidence

  • The dawn of ethnomicrobiology: an interdisciplinary research field on interactions between humans and microorganisms.

    • 2024-09-16
    • Review
    • Journal of ethnobiology and ethnomedicine 20(1)
    • • César Ojeda-Linares
      • Alejandro Casas
      • Tania González-Rivadeneira
      • Gary P Nabhan

    • PubMed: 39285478
    • DOI: 10.1186/s13002-024-00725-5

    1 Insight on

    • Improved Gastrointestinal Health

    • Low evidence
• September 17

  • A Comprehensive Overview of Postbiotics with a Special Focus on Discovery Techniques and Clinical Applications.

    • 2024-09-17
    • Review
    • Foods (Basel, Switzerland) 13(18)
    • • Anand Kumar
      • Katelyn M Green
      • Manmeet Rawat

    • PubMed: 39335866
    • DOI: 10.3390/foods13182937

    2 Insights on

    • Improved Skin Condition
    • Improved Skin Barrier Function

    • Low evidence

  • Exploring the Potential Probiotic Properties of Bifidobacterium breve DSM 32583-A Novel Strain Isolated from Human Milk.

    • 2024-09-17
    • Probiotics and antimicrobial proteins 17(6)
    • • Magdalena Kujawska
      • Klaus Neuhaus
      • Christopher Huptas
      • Esther Jiménez
      • Silvia Arboleya
      • Monika Schaubeck
      • Lindsay J Hall

    • PubMed: 39287748
    • DOI: 10.1007/s12602-024-10346-9

    4 Insights on

    • Improved Gut Microbiota Balance
    • Potential Probiotic Benefits
    • Reduced Virulence or Safety Concerns
    • No Detected Virulence or Plasmid-Associated Safety Concerns

    • Low evidence
    • Rigorous Journal
• September 18

  • From gut to brain: unveiling probiotic effects through a neuroimaging perspective-A systematic review of randomized controlled trials.

    • 2024-09-18
    • Systematic Review
    • Frontiers in nutrition 11
    • • Annachiara Crocetta
      • Donato Liloia
      • Tommaso Costa
      • Sergio Duca
      • Franco Cauda
      • Jordi Manuello

    • PubMed: 39360283
    • DOI: 10.3389/fnut.2024.1446854

    2 Insights on

    • Modified Resting-State Brain Connectivity
    • Improved Brain Function

    • High evidence
• September 20

  • Folate intake and the risk of endometrial cancer: A dose-response meta-analysis.

    • 2024-09-20
    • Meta-Analysis · n = 570
    • Medicine 103(38)
    • • Jiaye Long
      • Du Wang
      • Miyang Yang
      • Yingrong Pang
      • Meiqiong Li
      • Shuxin Qin
      • Kai Cui

    • PubMed: 39312350
    • DOI: 10.1097/md.0000000000039775

    1 Insight on

    • Reduced Endometrial Cancer Risk

    • High evidence

  • Meta-analysis of randomized controlled trials assessing the efficacy of nigella sativa supplementation for allergic rhinitis treatment.

    • 2024-09-20
    • Systematic Review
    • Frontiers in pharmacology 15
    • • Yuxiao He
      • Xiaoyan Hu
      • Lanyin Chang
      • Shuang Liu
      • Liangge Lv
      • Gang Qin
      • Liang Jiang

    • PubMed: 39372205
    • DOI: 10.3389/fphar.2024.1417013

    3 Insights on

    • Improved Allergic Rhinitis Total Effective Rate
    • Reduced Nasal Symptom Score
    • No Change in Adverse Event Rate

    • High evidence
• September 21

  • Probiotics and Non-Alcoholic Fatty Liver Disease: Unveiling the Mechanisms of Lactobacillus plantarum and Bifidobacterium bifidum in Modulating Lipid Metabolism, Inflammation, and Intestinal Barrier Integrity.

    • 2024-09-21
    • Review
    • Foods (Basel, Switzerland) 13(18)
    • • Jing Lu
      • Dilireba Shataer
      • Huizhen Yan
      • Xiaoxiao Dong
      • Minwei Zhang
      • Yanan Qin
      • Jie Cui
      • Liang Wang

    • PubMed: 39335920
    • DOI: 10.3390/foods13182992

    6 Insights on

    • Improved Intestinal Barrier Function
    • Improved Lipid Metabolism
    • Modulated Immune Response
    • Reduced Inflammation
    • Reduced Oxidative Stress
    • Reduced Hepatic Lipid Accumulation

    • Low evidence
• September 22

  • Does Colostrum Bovinum Supplementation Affect Swimming Performance in Endurance-Trained Males? A Randomized Placebo-Controlled Crossover Study.

    • 2024-09-22
    • RCT
    • Nutrients 16(18)
    • • Krzysztof Durkalec-Michalski
      • Natalia Główka
      • Tomasz Podgórski
      • Mikołaj Szymocha
      • Błażej Przybylik
      • Krystian Wochna
      • Małgorzata Woźniewicz
      • Paulina M Nowaczyk

    • PubMed: 39339805
    • DOI: 10.3390/nu16183204

    3 Insights on

    • Reduced Blood Lactate
    • Reduced Heart Rate
    • Improved Swimming Performance

    • High evidence
    • Rigorous Journal
• September 26

  • Role of L-carnitine in Cardiovascular Health: Literature Review.

    • 2024-09-26
    • Review
    • Cureus 16(9)
    • • Ramy Elantary
      • Samar Othman

    • PubMed: 39329040
    • DOI: 10.7759/cureus.70279

    5 Insights on

    • Improved Cardiovascular Health
    • Improved Cardiac Muscle Contractile Performance
    • Improved Cardiac Muscle Structural Integrity
    • Reduced Atherosclerosis Progression
    • Improved Post-Myocardial Infarction Outcome

    • Low evidence
• September 27

  • Thermophile-fermented feed modulates the gut microbiota related to lactate metabolism in pigs.

    • 2024-09-27
    • Observational
    • Journal of applied microbiology 135(10)
    • • Shota Yoshikawa
      • Kaede Itaya
      • Ryo Hoshina
      • Yukihiro Tashiro
      • Wataru Suda
      • Yuichiro Cho
      • Makiko Matsuura
      • Chie Shindo
      • Toshiyuki Ito
      • Masahira Hattori
      • Hirokuni Miyamoto
      • Hiroaki Kodama

    • PubMed: 39333026
    • DOI: 10.1093/jambio/lxae254

    1 Insight on

    • Modulated Gut Microbiota

    • Low evidence
    • Animal Study

  • A Novel Bifidobacterium longum Subsp. longum T1 Strain from Cow's Milk: Homeostatic and Antibacterial Activity against ESBL-Producing Escherichia coli.

    • 2024-09-27
    • Antibiotics (Basel, Switzerland) 13(10)
    • • Andrey V Machulin
      • Vyacheslav M Abramov
      • Igor V Kosarev
      • Evgenia I Deryusheva
      • Tatiana V Priputnevich
      • Alexander N Panin
      • Ashot M Manoyan
      • Irina O Chikileva
      • Tatiana N Abashina
      • Dmitriy A Blumenkrants
      • Olga E Ivanova
      • Tigran T Papazyan
      • Ilia N Nikonov
      • Nataliya E Suzina
      • Vyacheslav G Melnikov
      • Valentin S Khlebnikov
      • Vadim K Sakulin
      • Vladimir A Samoilenko
      • Alexey B Gordeev
      • Gennady T Sukhikh
      • Vladimir N Uversky
      • Andrey V Karlyshev

    • PubMed: 39452191
    • DOI: 10.3390/antibiotics13100924

    3 Insights on

    • Improved Intestinal Barrier Function
    • Improved Intestinal Alkaline Phosphatase Activity
    • Reduced ESBL-Producing Escherichia Coli Colonization

    • Low evidence
• September 30

  • Bowel Inflammation and Nutrient Supplementation: Effects of a Fixed Combination of Probiotics, Vitamins, and Herbal Extracts in an In Vitro Model of Intestinal Epithelial Barrier Dysfunction.

    • 2024-09-30
    • The Yale journal of biology and medicine 97(3)
    • • Mattia Tinazzi
      • Andrea Sacilotto
      • Veronica Cocetta
      • Isabella Giacomini
      • Floriana Raso
      • Giorgia Bulferi
      • Heide De Togni
      • Roberta Lanza
      • Pierluigi Consolo
      • Massimiliano Berretta
      • Monica Montopoli

    • PubMed: 39351327
    • DOI: 10.59249/jomf5336

    1 Insight on

    • Improved Intestinal Barrier Function

    • Low evidence

  • The Efficacy of Probiotics Supplementation on the Quality of Life of Patients with Gastrointestinal Disease: A Systematic Review of Clinical Studies.

    • 2024-09-30
    • Review
    • Preventive nutrition and food science 29(3)
    • • Jalal Moludi
      • Amir Saber
      • Morteza Arab Zozani
      • Shima Moradi
      • Yasaman Azamian
      • Salimeh Hajiahmadi
      • Yahya Pasdar
      • Fardin Moradi

    • PubMed: 39371511
    • DOI: 10.3746/pnf.2024.29.3.237

    1 Insight on

    • Improved Quality of Life

    • Low evidence
• Undated – 5 supplement studies

  • Effects of Bifidobacterium animalis subsp. lactis BB-12 and yogurt on mice during oral antibiotic administration.

    • 2024-09
    • Microbiological research 286
    • • Ruchita G Uttarwar
      • Solomon A Mekonnen
      • Wannes Van Beeck
      • Aidong Wang
      • Peter Finnegan
      • Robert F Roberts
      • Daniel Merenstein
      • Carolyn M Slupsky
      • Maria L Marco

    • PubMed: 38852301
    • DOI: 10.1016/j.micres.2024.127794

    2 Insights on

    • Reduced Antibiotic-Induced Gut Dysbiosis
    • Normalized Gut Metabolites

    • Low evidence
    • Animal Study

  • β-Alanine supplementation improves fractional anisotropy scores in the hippocampus and amygdala in 60-80-year-old men and women.

    • 2024-09
    • RCT
    • Experimental gerontology 194
    • • Ishay Ostfeld
      • Amit Zamir
      • Tavor Ben-Zeev
      • Chagai Levi
      • Yftach Gepner
      • David Peled
      • Daniel Barazany
      • Shmuel Springer
      • Jay R Hoffman

    • PubMed: 38971131
    • DOI: 10.1016/j.exger.2024.112513

    6 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Reduced C-Reactive Protein Levels
    • Reduced Glial Fibrillary Acidic Protein Level
    • Increased Brain-derived Neurotrophic Factor Level
    • Improved Hippocampal Fractional Anisotropy
    • Improved Amygdalar Fractional Anisotropy

    • High evidence

  • Effect of peanut butter supplementation on physical and cognitive functions in community-dwelling older adults: study protocol for a 6-month randomised controlled trial.

    • 2024-09
    • RCT · n = 120
    • BMJ open 14(9)
    • • Jeew Hettiarachchi
      • Ilili Feyesa
      • Robin M Daly
      • Elena S George
      • Ekavi N Georgousopoulou
      • David Scott
      • Brenton J Baguley
      • Sze-Yen Tan

    • PubMed: 39242158
    • DOI: 10.1136/bmjopen-2024-086232

    11 Insights on

    • Improved Nutritional Status
    • Improved Cognitive Function
    • Improved Body Composition
    • Improved Walking Speed
    • Improved Upper Body Strength
    • Improved Lower Body Strength
    • Improved Standing Balance
    • Improved Dynamic Balance
    • Improved Lower Body Power
    • Improved Lower Body Endurance
    • Increased Telomere Length

    • High evidence
    • Large Human Trial

  • Synergistic effects of oral inoculation with a recombinant Lactobacillus plantarum NC8 strain co-expressing interleukin-2 and interleukin-17B on the efficacy of the infectious bronchitis vaccine in chickens.

    • 2024-09
    • Poultry science 103(9)
    • • Shaohua Guo
      • Junjie Peng
      • Yongle Xiao
      • Jianlin Chen
      • Rong Gao

    • PubMed: 38981363
    • DOI: 10.1016/j.psj.2024.103908

    3 Insights on

    • Improved Growth Performance
    • Improved Immune Response to Vaccination
    • Reduced Lung Viral Proliferation

    • Low evidence
    • Animal Study

  • Clinical effects of Hibiscus sabdariffa Linn. on obesity treatment: A systematic review and meta-analysis of randomized controlled trials.

    • 2024-09
    • Meta-Analysis · n = 339
    • Complementary therapies in medicine 84
    • • Piyameth Dilokthornsakul
      • Natnicha Rattanachaisit
      • Phiyanuch Thimkorn
      • Supawan Pongpattanawut
      • Witoo Dilokthornsakul
      • Teerapon Dhippayom

    • PubMed: 38878905
    • DOI: 10.1016/j.ctim.2024.103063

    3 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Body Weight

    • High evidence