November 2019 Supplement Research Papers

• November 1

  • A Multi-strain Potential Probiotic Formulation of GABA-Producing Lactobacillus plantarum 90sk and Bifidobacterium adolescentis 150 with Antidepressant Effects

    • 2019-11-01
    • Clinical Trial
    • Probiotics and Antimicrobial Proteins 12(3)
    • • R. Yunes
      • E. Poluektova
      • E. Vasileva
      • M. Odorskaya
      • M. Marsova
      • G. Kovalev
      • V. Danilenko

    • PubMed: 31677091
    • DOI: 10.1007/s12602-019-09601-1

    1 Insight on

    • Reduced Depressive Behavior

    • Low evidence
    • Highly Cited
    • Animal Study
• November 4

  • Evaluation of different inclusion levels of dry live yeast impacts on various rumen parameters and in situ digestibilities of dry matter and neutral detergent fiber in growing and finishing beef cattle.

    • 2019-11-04
    • RCT
    • Journal of Animal Science 97(12)
    • • Caitlyn M Cagle
      • L. F. Batista
      • Robin C. Anderson
      • M. Fonseca
      • M. Cravey
      • C. Julien
      • L. Tedeschi

    • PubMed: 31679025
    • DOI: 10.1093/jas/skz342

    4 Insights on

    • Improved Digestibility of Neutral Detergent Fiber
    • Increased Fiber Carbohydrate Degradation Rate
    • Reduced Methane Concentration
    • Increased Protozoa Counts

    • High evidence
    • Rigorous Journal
• November 6

  • Saccharomyces boulardii alleviates ulcerative colitis carcinogenesis in mice by reducing TNF-α and IL-6 levels and functions and by rebalancing intestinal microbiota

    • 2019-11-06
    • RCT
    • BMC Microbiology 19(1)
    • • Chunsaier Wang
      • Wen-bin Li
      • Hongying Wang
      • Yiming Ma
      • Xinhua Zhao
      • Xudong Zhang
      • Hong Yang
      • J. Qian
      • Jingnan Li

    • PubMed: 31694526
    • DOI: 10.1186/s12866-019-1610-8

    4 Insights on

    • Reduced TNF-α Levels
    • Improved Intestinal Microflora Balance
    • Reduced IL-6 Levels
    • Reduced Colorectal Cancer Risk Associated with Ulcerative Colitis

    • Low evidence
    • Highly Cited
    • Animal Study

  • Heat-killed Lactobacillus reuteri and cell-free culture supernatant have similar effects to viable probiotics during interaction with Porphyromonas gingivalis.

    • 2019-11-06
    • Journal of Periodontal Research 55(2)
    • • B. Geraldo
      • Marianna N Batalha
      • N. V. Milhan
      • R. D. Rossoni
      • L. Scorzoni
      • A. Anbinder

    • PubMed: 31691977
    • DOI: 10.1111/jre.12704

    2 Insights on

    • Reduced Porphyromonas gingivalis Colony-Forming Units
    • Increased Hemocyte Density

    • Low evidence
• November 7

  • The efficacy of combined l-carnitine and l-acetyl carnitine in men with idiopathic oligoasthenoteratozoospermia: A systematic review and meta-analysis.

    • 2019-11-07
    • Meta-Analysis · n = 693
    • Andrologia 52(2)
    • • Xuebao Zhang
      • Yuanshan Cui
      • Liying Dong
      • Miao Sun
      • Yong Zhang

    • PubMed: 31701550
    • DOI: 10.1111/and.13470

    7 Insights on

    • Increased Forward Sperm Motility
    • Increased Motile Sperm Count
    • Increased Number of Pregnancies
    • Increased Sperm Motility
    • Increased Sperm Concentration
    • Increased Semen Volume
    • Reduced Atypical Sperm Form

    • High evidence
• November 8

  • Gamma-aminobutyric acid-producing lactobacilli positively affect metabolism and depressive-like behaviour in a mouse model of metabolic syndrome

    • 2019-11-08
    • Clinical Trial
    • Scientific Reports 9(1)
    • • E. Patterson
      • E. Patterson
      • P. Ryan
      • P. Ryan
      • Niamh C Wiley
      • Niamh C Wiley
      • I. Carafa
      • I. Carafa
      • E. Sherwin
      • G. Moloney
      • E. Franciosi
      • R. Mandal
      • D. Wishart
      • D. Wishart
      • K. Tuohy
      • R. Ross
      • J. Cryan
      • Ted G. Dinan
      • C. Stanton
      • C. Stanton

    • PubMed: 31704943
    • DOI: 10.1038/s41598-019-51781-x

    4 Insights on

    • Reduced Adipose Tissue Weight
    • Enhanced Insulin Secretion
    • Improved Plasma Cholesterol Clearance
    • Reduced Despair-Like Behavior

    • Low evidence
    • Highly Cited
    • Rigorous Journal
    • Animal Study
• November 9

  • Bifidobacterium bifidum: A Key Member of the Early Human Gut Microbiota

    • 2019-11-09
    • Microorganisms 7(11)
    • • F. Turroni
      • S. Duranti
      • C. Milani
      • G. Lugli
      • D. van Sinderen
      • M. Ventura

    • PubMed: 31717486
    • DOI: 10.3390/microorganisms7110544

    2 Insights on

    • Increased Adhesion to Epithelia
    • Improved Metabolism of Host-Derived Glycans

    • Low evidence
    • Rigorous Journal

  • Effects of Lactobacillus reuteri DSM 17938 in preterm infants: a double-blinded randomized controlled study

    • 2019-11-09
    • RCT · n = 114
    • Italian Journal of Pediatrics 45(1)
    • • Xuewei Cui
      • Yongyan Shi
      • Siyang Gao
      • Xindong Xue
      • Jianhua Fu

    • PubMed: 31706331
    • DOI: 10.1186/s13052-019-0716-9

    16 Insights on

    • Improved Bowel Movement Frequency
    • Increased Bowel Movement Frequency
    • Reduced Hospitalization Duration
    • Improved Average Daily Gain
    • No Adverse Health Effects
    • Reduced Necrotising Enterocolitis
    • Reduced Sepsis Incidence
    • Increased Head Circumference
    • Reduced Length of Hospital Stay
    • Reduced Time to Full Enteral Feeding
    • Increased Defecation Frequency
    • Reduced Reflux Episodes
    • Increased Body Length
    • Reduced Reflux Episode Rate
    • Increased Daily Weight Gain
    • Reduced Localized Infection

    • High evidence
    • Rigorous Journal
• November 10

  • Effect of in Ovo Inoculation of Bifidobacterium spp. on Growth Performance, Thyroid Activity, Ileum Histomorphometry, and Microbial Enumeration of Broilers

    • 2019-11-10
    • RCT
    • Probiotics and Antimicrobial Proteins 12(3)
    • • A. Abdel-Moneim
      • A. Elbaz
      • R. Khidr
      • F. Badri

    • PubMed: 31709505
    • DOI: 10.1007/s12602-019-09613-x

    7 Insights on

    • Increased Body Weight
    • Improved Growth Performance
    • Increased Beneficial Gut Microbiota
    • Improved Total Antioxidant Status
    • Improved Intestinal Mucosa Architecture
    • Increased Serum Free Thyroxine Levels
    • Increased Beneficial Bacterial Species

    • High evidence
• November 12

  • Lactobacillus helveticus R0052 alleviates liver injury by modulating gut microbiome and metabolome in d-galactosamine-treated rats

    • 2019-11-12
    • Clinical Trial
    • Applied Microbiology and Biotechnology 103(23-24)
    • • Qiangqiang Wang
      • L. Lv
      • Huiyong Jiang
      • Kaicen Wang
      • Ren Yan
      • Yating Li
      • Jianzhong Ye
      • Jingjing Wu
      • Qing Wang
      • Xiaoyuan Bian
      • Liya Yang
      • Xianwan Jiang
      • Jiaojiao Xie
      • Yanmeng Lu
      • Jian Shen
      • Lanjuan Li

    • PubMed: 31713675
    • DOI: 10.1007/s00253-019-10211-8

    20 Insights on

    • Improved Gut Microbiota Composition
    • Improved Intestinal Barrier Function
    • Improved Gastrointestinal Health
    • Reduced Aminotransferase Levels
    • Reduced Bilirubin Levels
    • Reduced Total Bile Acid Levels
    • Reduced Liver Inflammation
    • Improved Gut Microbiome
    • Improved Intestinal Function
    • Improved Liver Function
    • Reduced Inflammation Levels
    • Improved Metabolic Function
    • Reduced Liver Enzyme Levels
    • Reduced Inflammation
    • Improved Metabolic Health
    • Reduced Hepatic Histological Injury
    • Improved Metabolome Profile
    • Reduced Liver Injury Indicators
    • Alleviated Liver Injury
    • Reduced Histological Liver Injury

    • Low evidence
    • Animal Study
• November 14

  • A dual‐strain Lactobacilli reuteri probiotic improves the treatment of residual pockets: A randomized controlled clinical trial

    • 2019-11-14
    • RCT · n = 39
    • Journal of Clinical Periodontology 47(1)
    • • I. Laleman
      • M. Pauwels
      • M. Quirynen
      • W. Teughels

    • PubMed: 31520543
    • DOI: 10.1111/jcpe.13198

    3 Insights on

    • Reduced Surgical Intervention
    • Reduced Probing Depth
    • Reduced Residual Pockets

    • High evidence

  • Systematic Review with Meta-Analysis: Lactobacillus reuteri DSM 17938 for Treating Acute Gastroenteritis in Children. An Update

    • 2019-11-14
    • Meta-Analysis
    • Nutrients 11(11)
    • • B. Patro-Gołąb
      • H. Szajewska

    • PubMed: 31739457
    • DOI: 10.3390/nu11112762

    5 Insights on

    • Reduced Duration of Diarrhea
    • Reduced Hospitalization Duration
    • Reduced Stool Volume
    • Reduced Diarrhea Rate
    • Reduced Duration of Hospitalization

    • High evidence

  • Effect of Lactobacillus gasseri PA3 on gut microbiota in an in vitro colonic simulation

    • 2019-11-14
    • Food Science & Nutrition 7(12)
    • • Shasha Xiang
      • Jian Fu
      • Kun T. Ye
      • Yiqing Zheng
      • Xuan Zhu
      • Jie Chen
      • Yuewen Chen

    • PubMed: 31890166
    • DOI: 10.1002/fsn3.1236

    1 Insight on

    • Reduced Purine Metabolism

    • Low evidence
• November 15

  • Lactobacillus fermentum: a bacterial species with potential for food preservation and biomedical applications

    • 2019-11-15
    • Critical Reviews in Food Science and Nutrition 60(20)
    • • K. Naghmouchi
      • Y. Belguesmia
      • F. Bendali
      • G. Spano
      • B. Seal
      • D. Drider

    • PubMed: 31729242
    • DOI: 10.1080/10408398.2019.1688250

    14 Insights on

    • Reduced Total Cholesterol Levels
    • Improved Immune Response
    • Reduced Serum Cholesterol Levels
    • Enhanced Immune Response
    • Reduced Incidence of Upper Respiratory Tract Infections
    • Reduced Gastrointestinal Infections
    • Enhanced Antimicrobial Peptide Production
    • Reduced Blood Cholesterol
    • Reduced Respiratory Infections
    • Reduced Community-Acquired Gastrointestinal Infections
    • Prevention of Alcoholic Liver Disease
    • Reduced Risk of Colorectal Cancer
    • Prevention of Colorectal Cancer
    • Reduced Blood Stream Cholesterol

    • Low evidence
• November 16

  • Evaluation of the efficacy of Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2 on aspects of common cold infections in children attending day care: a randomised, double-blind, placebo-controlled clinical study

    • 2019-11-16
    • RCT · n = 131
    • European Journal of Nutrition 59(1)
    • • I. Lazou Ahrén
      • A. Berggren
      • Cristina Teixeira
      • Titti Martinsson Niskanen
      • N. Larsson

    • PubMed: 31734734
    • DOI: 10.1007/s00394-019-02137-8

    9 Insights on

    • Reduced Severity of Nasal Congestion and Runny Nose
    • Reduced Concomitant Medication Usage
    • Reduced Day Care Absence
    • Reduced Severity of Symptoms Per Day
    • Reduced Severity of Excessive Crying
    • Reduced Severity of Common Cold Symptoms
    • Reduced Mean Total Severity per Day in Reported Episodes
    • Reduced Crying Frequency
    • Reduced Daily Episode Severity

    • High evidence
    • Rigorous Journal
• November 19

  • Effect of Lactobacillus plantarum TWK10 on Exercise Physiological Adaptation, Performance, and Body Composition in Healthy Humans

    • 2019-11-19
    • RCT · n = 54
    • Nutrients 11(11)
    • • Wen-Ching Huang
      • Mon-Chien Lee
      • Chia-Chia Lee
      • Ker-Sin Ng
      • Y. Hsu
      • Tsung-Yu Tsai
      • S. Young
      • Jin-Seng Lin
      • Chi-Chang Huang

    • PubMed: 31752370
    • DOI: 10.3390/nu11112836

    4 Insights on

    • Increased Muscle Mass
    • Reduced Body Fat
    • Improved Exercise Performance
    • Improved Fatigue-Associated Features

    • High evidence
• November 20

  • Infant formula containing galacto-and fructo-oligosaccharides and Bifidobacterium breve M-16V supports adequate growth and tolerance in healthy infants in a randomised, controlled, double-blind, prospective, multicentre study

    • 2019-11-20
    • RCT · n = 359
    • Journal of Nutritional Science 5
    • • M. Abrahamse-Berkeveld
      • M. Alles
      • E. Franke-Beckmann
      • K. Helm
      • R. Knecht
      • R. Köllges
      • B. Sandner
      • J. Knol
      • K. Ben Amor
      • A. Bufe

    • PubMed: 28620469
    • DOI: 10.1017/jns.2016.35

    9 Insights on

    • Similar Frequency of Adverse Events
    • Increased Fecal Bifidobacteria Levels
    • Increased Adverse Events
    • Achieved Adequate Infant Growth
    • Reduced Faecal Clostridium Population
    • Improved Growth Metrics
    • Reduced Percentage of Clostridium lituseburense and Clostridium histolyticum
    • Reduced Fecal Clostridium Levels
    • No Significant Changes in Blood Parameters

    • High evidence
    • Large Human Trial

  • Long-Chain Polyphosphate Is a Potential Agent for Inducing Mucosal Healing of the Colon in Ulcerative Colitis.

    • 2019-11-20
    • Clinical Trial
    • Clinical pharmacology and therapeutics 107(2)
    • • Mikihiro Fujiya
      • Nobuhiro Ueno
      • Shin Kashima
      • Kazuyuki Tanaka
      • Aki Sakatani
      • Katsuyoshi Ando
      • Kentaro Moriichi
      • Hiroaki Konishi
      • Naoya Kamiyama
      • Yoshikazu Tasaki
      • Tomohiro Omura
      • Kazuo Matsubara
      • Masaki Taruishi
      • Toshikatsu Okumura

    • PubMed: 31513280
    • DOI: 10.1002/cpt.1628

    2 Insights on

    • Maintained Remission in Ulcerative Colitis
    • Improved Mucosal Healing

    • Moderate evidence
• November 25

  • The usage of a lactobacilli probiotic in the non-surgical therapy of peri-implantitis: A randomized pilot study.

    • 2019-11-25
    • RCT
    • Clinical Oral Implants Research 31(1)
    • • I. Laleman
      • M. Pauwels
      • M. Quirynen
      • W. Teughels

    • PubMed: 31705683
    • DOI: 10.1111/clr.13555

    2 Insights on

    • Reduced Plaque Levels
    • Reduced Bleeding on Probing (BOP)

    • High evidence
• November 30

  • Bifidobacteria adolescentis regulated immune responses and gut microbial composition to alleviate DNFB-induced atopic dermatitis in mice

    • 2019-11-30
    • RCT · n = 9
    • European Journal of Nutrition 59(7)
    • • Zhifeng Fang
      • Lingzhi Li
      • Jianxian Zhao
      • Hao Zhang
      • Yuan-Kun Lee
      • Wenwei Lu
      • Wei Chen

    • PubMed: 31786642
    • DOI: 10.1007/s00394-019-02145-8

    7 Insights on

    • Increased Fecal Lactobacilli
    • Improved Atopic Dermatitis Symptoms
    • Increased Regulatory T Cell Populations
    • Increased Short-Chain Fatty Acid Production
    • Enhanced Beneficial Gut Microbiota
    • Enhanced Immune Response Regulation
    • Enhanced Functional Gut Microbial Pathways

    • Low evidence
    • Rigorous Journal
    • Animal Study
• Undated – 12 supplement studies

  • Lactobacillus fermentum and/or ferulic acid improved the immune responses, antioxidative defence and resistance against Aeromonas hydrophila in common carp (Cyprinus carpio) fingerlings.

    • 2019-11
    • RCT
    • Fish & Shellfish Immunology 94
    • • E. Ahmadifar
      • M. Moghadam
      • M. Dawood
      • S. Hoseinifar

    • PubMed: 31604151
    • DOI: 10.1016/j.fsi.2019.10.019

    15 Insights on

    • Increased Body Weight
    • Improved Survival Rate
    • Improved Immune Response
    • Improved Growth Performance
    • Enhanced Disease Resistance
    • Enhanced Immune Response
    • Improved Feed Utilization
    • Enhanced Antioxidant Enzyme Activity
    • Improved Growth Metrics
    • Improved Hematological Parameters
    • Improved Antioxidant Defense
    • Improved Serum Biochemistry
    • Improved Serum Protein Levels
    • Increased Survival Against Pathogens
    • Increased Survival Rate Against A. hydrophila

    • Low evidence
    • Animal Study

  • Inhibition of Escherichia coli adhesion to human intestinal Caco-2 cells by probiotic candidate Lactobacillus plantarum strain L15.

    • 2019-11
    • Microbial Pathogenesis 136
    • • B. A. Behbahani
      • M. Noshad
      • F. Falah

    • PubMed: 31437574
    • DOI: 10.1016/j.micpath.2019.103677

    1 Insight on

    • Reduced Enteropathogenic Escherichia coli (EPEC) Adhesion

    • Low evidence

  • Effect of Bacillus subtilis DSM 32315 on the intestinal structural integrity and growth performance of broiler chickens under necrotic enteritis challenge.

    • 2019-11
    • RCT
    • Poultry Science 98(11)
    • • A. Sokale
      • A. Menconi
      • G. Mathis
      • B. Lumpkins
      • M. Sims
      • R. Whelan
      • K. Doranalli

    • PubMed: 31250009
    • DOI: 10.3382/ps/pez368

    7 Insights on

    • Reduced Colitis-Related Mortality
    • Improved Body Weight
    • Reduced Intestinal NE Lesion Score
    • Improved Production Efficiency
    • Reduced Enteritis Index
    • Reduced Crypt Depth
    • Increased Villus Height to Crypt Depth Ratio

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • The role of gut microbiome in the pathogenesis of psoriasis and the therapeutic effects of probiotics.

    • 2019-11
    • Review
    • Journal of family medicine and primary care 8(11)
    • • Dalal I Alesa
      • Haidar M Alshamrani
      • Yahya A Alzahrani
      • Dania N Alamssi
      • Nada S Alzahrani
      • Marwan E Almohammadi

    • PubMed: 31803643
    • DOI: 10.4103/jfmpc.jfmpc_709_19

    1 Insight on

    • Reduced Psoriasis Symptoms

    • Low evidence

  • Lactobacillus reuteri ZJ617 Culture Supernatant Attenuates Acute Liver Injury Induced in Mice by Lipopolysaccharide.

    • 2019-11
    • RCT · n = 6
    • The Journal of Nutrition 149(11)
    • • Yanjun Cui
      • S. Qi
      • Wenming Zhang
      • Jiangdi Mao
      • Renlong Tang
      • Chong Wang
      • Jianxin Liu
      • Xin M. Luo
      • Haifeng Wang

    • PubMed: 31152671
    • DOI: 10.1093/jn/nxz088

    6 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Inflammatory Pathway Activity
    • Enhanced Anti-inflammatory Response
    • Reduced Hepatic Inflammation
    • Reduced Hepatic Histological Injury
    • Reduced Hepatic Apoptosis

    • Low evidence
    • Animal Study

  • Effect of dietary supplementation of Bacillus subtilis DSM29784 on hen performance, egg quality indices, and apparent retention of dietary components in laying hens from 19 to 48 weeks of age.

    • 2019-11
    • RCT · n = 336
    • Poultry Science 98(11)
    • • M. Neijat
      • R. Shirley
      • J. Barton
      • P. Thiery
      • A. Welsher
      • E. Kiarie

    • PubMed: 31222316
    • DOI: 10.3382/ps/pez324

    6 Insights on

    • Increased Body Weight
    • Improved Egg Mass During Layer I for Low Dose
    • Improved Dietary Component Retention
    • Improved Egg Mass
    • Improved Nutrient Retention
    • Reduced Shell Breaking Strength

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • UCC118 supplementation reduces exercise-induced gastrointestinal permeability and remodels the gut microbiome in healthy humans.

    • 2019-11
    • RCT
    • Physiological reports 7(22)
    • • Christopher L Axelrod
      • Connery J Brennan
      • Gail Cresci
      • Deborah Paul
      • Michaela Hull
      • Ciarán E Fealy
      • John P Kirwan

    • PubMed: 31758610
    • DOI: 10.14814/phy2.14276

    2 Insights on

    • Reduced Intestinal Permeability
    • Microbiome Remodeling

    • High evidence

  • Bacillus coagulans GBI-30, 6068 decreases upper respiratory and gastrointestinal tract symptoms in healthy Mexican scholar-aged children by modulating immune-related proteins.

    • 2019-11
    • RCT · n = 80
    • Food Research International 125
    • • M. Anaya-Loyola
      • J. A. Enciso-Moreno
      • J. López-Ramos
      • G. García-Marín
      • María Y Orozco Álvarez
      • Ana M Vega-García
      • J. Mosqueda
      • D. García-Gutiérrez
      • D. Keller
      • I. Pérez-Ramírez

    • PubMed: 31554075
    • DOI: 10.1016/J.FOODRES.2019.108567

    15 Insights on

    • Reduced Flatulence
    • Reduced Nasal Congestion
    • Increased Immune Marker Levels
    • Reduced Upper Respiratory Tract Infection Symptoms
    • Reduced Duration of URTI-Associated Symptoms
    • Reduced Incidence of Gastrointestinal Tract Infection Symptoms
    • Reduced Flatulence Incidence
    • Altered Serum Immune Protein Levels
    • Reduced Bloody Nasal Mucus
    • Reduced Itchy Nose
    • Reduced Hoarseness
    • Reduced Hoarseness Duration
    • Reduced Headache Duration
    • Reduced Red Eye Duration
    • Reduced Fatigue Duration

    • High evidence

  • In vitro inhibitory activity of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 alone or in combination against bacterial and Candida reference strains and clinical isolates

    • 2019-11
    • Heliyon 5(11)
    • • Rosanna Inturri
      • L. Trovato
      • G. Volti
      • S. Oliveri
      • G. Blandino

    • PubMed: 31799467
    • DOI: 10.1016/j.heliyon.2019.e02891

    1 Insight on

    • Reduced Pathogenic Microorganism Activity

    • Low evidence

  • A prospective, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of SNZ TriBac, a three-strain Bacillus probiotic blend for undiagnosed gastrointestinal discomfort

    • 2019-11
    • RCT · n = 60
    • International Journal of Colorectal Disease 34(11)
    • • R. J. Soman
      • M. Swamy

    • PubMed: 31686199
    • DOI: 10.1007/s00384-019-03416-w

    12 Insights on

    • Reduced Bloating
    • Reduced Gastrointestinal Symptoms
    • No Adverse Events Observed
    • Reduced Burping Frequency
    • Reduced Sour Taste Perception
    • Improved Total SODA Scores
    • Reduced Pain Symptoms
    • Reduced Non-Pain Symptoms
    • Improved Satisfaction
    • Reduced Gastrointestinal Discomfort Symptoms
    • Reduced Pain Levels
    • Improved Gastrointestinal Discomfort

    • High evidence
    • Rigorous Journal

  • Effects of the probiotic Bacillus amyloliquefaciens on the growth, immunity, and disease resistance of Haliotis discus hannai.

    • 2019-11
    • RCT
    • Fish & Shellfish Immunology 94
    • • Gao Xiaolong
      • Ke Caihuan
      • Z. Mo
      • Li Xian
      • Wu Fucun
      • L. Ying

    • PubMed: 31465875
    • DOI: 10.1016/j.fsi.2019.08.067

    3 Insights on

    • Improved Growth Rate
    • Improved Antioxidant Capacity
    • Improved Immunity

    • High evidence

  • The effects of pumpkin seed oil supplementation on arterial hemodynamics, stiffness and cardiac autonomic function in postmenopausal women.

    • 2019-11
    • RCT · n = 12
    • Complementary therapies in clinical practice 37
    • • Alexei Wong
      • Danielle Viola
      • Douglas Bergen
      • Eileen Caulfield
      • Javad Mehrabani
      • Arturo Figueroa

    • PubMed: 31445363
    • DOI: 10.1016/j.ctcp.2019.08.003

    6 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure
    • Reduced Arterial Stiffness
    • Reduced Augmentation Index
    • Reduced Central Systolic Blood Pressure
    • Improved Heart Rate Variability

    • High evidence