December 2020 Supplement Research Papers

• December 1

  • Effects of Capsicum annuum supplementation on the components of metabolic syndrome: a systematic review and meta-analysis.

    • 2020-12-01
    • Meta-Analysis · n = 609
    • Scientific reports 10(1)
    • • Hwan-Hee Jang
      • Jounghee Lee
      • Sung-Hyen Lee
      • Young-Min Lee

    • PubMed: 33262398
    • DOI: 10.1038/s41598-020-77983-2

    1 Insight on

    • Reduced Body Weight

    • High evidence
    • Rigorous Journal
• December 2

  • Lactobacillus plantarum DR7 improved brain health in aging rats via the serotonin, inflammatory and apoptosis pathways.

    • 2020-12-02
    • Clinical Trial · n = 6
    • Beneficial Microbes 11(8)
    • • A. I. Zaydi
      • L. Lew
      • Y. Hor
      • M. Jaafar
      • L. Chuah
      • K. Yap
      • A. Azlan
      • G. Azzam
      • M. Liong

    • PubMed: 33245015
    • DOI: 10.3920/BM2019.0200

    3 Insights on

    • Reduced Anxiety Levels
    • Reduced Pro-inflammatory Cytokine Levels
    • Improved Memory Function

    • Low evidence
    • Animal Study
• December 3

  • Effects of Dietary Supplementation with Clostridium butyricum on Growth Performance, Serum Immunity, Intestinal Morphology, and Microbiota as an Antibiotic Alternative in Weaned Piglets

    • 2020-12-03
    • Clinical Trial · n = 120
    • Animals 10(12)
    • • Yunsheng Han
      • C. Tang
      • Ying Li
      • Yanan Yu
      • T. Zhan
      • Qingyu Zhao
      • Jun-min Zhang

    • PubMed: 33287332
    • DOI: 10.3390/ani10122287

    7 Insights on

    • Increased Short-Chain Fatty Acid Levels
    • Reduced Diarrhea Incidence
    • Improved Intestinal Function
    • Improved Growth Performance
    • Enhanced Beneficial Gut Microbiota
    • Improved Digestibility
    • Improved Serum Immunity

    • Low evidence
    • Rigorous Journal
    • Animal Study
• December 7

  • Prebiotic, Probiotic, Antimicrobial, and Functional Food Applications of Bacillus amyloliquefaciens.

    • 2020-12-07
    • Journal of Agricultural and Food Chemistry 68(50)
    • • Kalekristos WoldemariamYohannes
      • Zhenfang Wan
      • Qinglin Yu
      • Hongyan Li
      • Xuetuan Wei
      • Yingli Liu
      • Jing Wang
      • Baoguo Sun

    • PubMed: 33280382
    • DOI: 10.1021/acs.jafc.0c06396

    2 Insights on

    • Enhanced Antimicrobial Resistance
    • Improved Functional Properties of Food

    • Low evidence

  • Interventions for itch in people with advanced chronic kidney disease.

    • 2020-12-07
    • Meta-Analysis · n = 4,466
    • The Cochrane database of systematic reviews 2020(12)
    • • Daniel Hercz
      • Simon H Jiang
      • Angela C Webster

    • PubMed: 33283264
    • DOI: 10.1002/14651858.cd011393.pub2

    1 Insight on

    • Reduced Itch Severity

    • High evidence
• December 8

  • Probiotics for treating acute infectious diarrhoea.

    • 2020-12-08
    • Meta-Analysis · n = 4,056
    • The Cochrane database of systematic reviews 2020(12)
    • • Shelui Collinson
      • Andrew Deans
      • April Padua-Zamora
      • Germana V Gregorio
      • Chao Li
      • Leonila F Dans
      • Stephen J Allen

    • PubMed: 33295643
    • DOI: 10.1002/14651858.cd003048.pub4

    1 Insight on

    • Reduced Duration of Acute Diarrhoea

    • High evidence

  • Functional and Genomic Characterization of Ligilactobacillus salivarius TUCO-L2 Isolated From Lama glama Milk: A Promising Immunobiotic Strain to Combat Infections.

    • 2020-12-08
    • Frontiers in microbiology 11
    • • Sandra Quilodrán-Vega
      • Leonardo Albarracin
      • Flavia Mansilla
      • Lorena Arce
      • Binghui Zhou
      • Md Aminul Islam
      • Mikado Tomokiyo
      • Imad Al Kassaa
      • Yoshihito Suda
      • Haruki Kitazawa
      • Julio Villena

    • PubMed: 33363529
    • DOI: 10.3389/fmicb.2020.608752

    6 Insights on

    • Reduced TLR Inflammatory Activation
    • Improved Resistance to Pathogenic Infection
    • Modulated Innate Immune Response
    • Reduced Susceptibility to Bacterial Infection
    • Reduced Susceptibility to Enteric Infection
    • Improved Gastrointestinal Pathogen Inhibition

    • Low evidence

  • Lactobacillus rhamnosus MP108: Toxicological evaluation.

    • 2020-12-08
    • Clinical Trial
    • Journal of Food Science 86(1)
    • • Bo Zhang
      • B. Lynch
      • Jian Zhao
      • Yu Guo
      • A. Mak

    • PubMed: 33295011
    • DOI: 10.1111/1750-3841.15546

    4 Insights on

    • Reduced Genotoxicity
    • Reduced Toxicity
    • Absence of Pathogenicity
    • Ensured Safety

    • Low evidence
    • Animal Study

  • Impact of Streptococcus salivarius K12 on Nasopharyngeal and Saliva Microbiome: A Randomized Controlled Trial.

    • 2020-12-08
    • RCT · n = 121
    • The Pediatric infectious disease journal 40(5)
    • • Suvi Sarlin
      • Mysore V Tejesvi
      • Jenni Turunen
      • Petri Vänni
      • Tytti Pokka
      • Marjo Renko
      • Terhi Tapiainen

    • PubMed: 33298762
    • DOI: 10.1097/inf.0000000000003016

    10 Insights on

    • Increased Salivary Streptococcus salivarius K12 Levels
    • Reduced Otopathogen Abundance
    • Changed Saliva Microbiome Diversity
    • Changed Nasopharyngeal Microbiome Diversity
    • Reduced Otopathogen Prevalence
    • Reduced Nasopharyngeal Microbiome Diversity
    • Reduced Saliva Microbiome Diversity
    • Reduced Otopathogen Carriage
    • Reduced Moraxella Abundance
    • Reduced Nasopharyngeal Moraxella Abundance

    • High evidence
    • Large Human Trial
• December 10

  • Pediococcus pentosaceus PP04 Ameliorates High-Fat Diet-Induced Hyperlipidemia by Regulating Lipid Metabolism in C57BL/6N Mice.

    • 2020-12-10
    • Clinical Trial
    • Journal of Agricultural and Food Chemistry 68(51)
    • • Yu Wang
      • Ying You
      • Yuan Tian
      • Haiyue Sun
      • Xia Li
      • Xiujuan Wang
      • Yuhua Wang
      • Jingsheng Liu

    • PubMed: 33300795
    • DOI: 10.1021/acs.jafc.0c05060

    10 Insights on

    • Reduced Total Cholesterol Levels
    • Reduced Low-Density Lipoprotein Level
    • Reduced Hepatic Oxidative Stress
    • Reduced Triglyceride Levels
    • Improved Lipid Metabolism
    • Reduced Inflammation Levels
    • Reduced Liver Injury
    • Enhanced Antioxidant Activity
    • Reduced Free Fatty Acid Levels
    • Reduced Liver Injury Indicators

    • Low evidence
    • Animal Study

  • Probiotic Lactobacillus fermentum strain JDFM216 improves cognitive behavior and modulates immune response with gut microbiota

    • 2020-12-10
    • Clinical Trial
    • Scientific Reports 10(1)
    • • M. Park
      • Minhye Shin
      • Daye Mun
      • Seong-Yeop Jeong
      • Do-Youn Jeong
      • Minho Song
      • Gwangpyo Ko
      • T. Unno
      • Younghoon Kim
      • Sangnam Oh

    • PubMed: 33303803
    • DOI: 10.1038/s41598-020-77587-w

    4 Insights on

    • Improved Cognitive Behavior
    • Improved Phagocytic Activity of Macrophages
    • Increased Secretory IgA Production
    • Stimulation of Immune Cells

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Effect of probiotics, Bifidobacterium bifidum G9-1, on gastrointestinal symptoms in patients with type 2 diabetes mellitus: study protocol for open-label, single-arm, exploratory research trial (Big STAR study)

    • 2020-12-10
    • Journal of Clinical Biochemistry and Nutrition 67(3)
    • • Y. Hashimoto
      • Hanako Nakajima
      • Shinnosuke Hata
      • Tomoki Miyoshi
      • Yukako Hosomi
      • Saori Majima
      • Naoko Nakanishi
      • Takafumi Senmaru
      • T. Osaka
      • Hiroshi Okada
      • Emi Ushigome
      • M. Hamaguchi
      • M. Asano
      • M. Yamazaki
      • M. Fukui

    • PubMed: 33293761
    • DOI: 10.3164/jcbn.20-100

    1 Insight on

    • Improved Gastrointestinal Symptoms

    • Low evidence
    • Rigorous Journal
• December 11

  • Lactobacillus delbrueckii Interfere With Bile Acid Enterohepatic Circulation to Regulate Cholesterol Metabolism of Growing–Finishing Pigs via Its Bile Salt Hydrolase Activity

    • 2020-12-11
    • RCT · n = 2
    • Frontiers in Nutrition 7
    • • G. Hou
      • Wei Peng
      • Liangkai Wei
      • Rui Li
      • Yong Yuan
      • Xingguo Huang
      • Yulong Yin

    • PubMed: 33363199
    • DOI: 10.3389/fnut.2020.617676

    3 Insights on

    • Reduced Triglyceride Levels
    • Reduced Serum Total Cholesterol Levels
    • Increased Cholesterol Excretion

    • Low evidence
    • Animal Study
• December 14

  • Leuconostoc mesenteroides mediates an electrogenic pathway to attenuate the accumulation of abdominal fat mass induced by high fat diet

    • 2020-12-14
    • Clinical Trial
    • Scientific Reports 10(1)
    • • M. T. Pham
      • J. Yang
      • A. Balasubramaniam
      • A. Rahim
      • Prakoso Adi
      • T. Do
      • D. Herr
      • Chun-Ming Huang

    • PubMed: 33318546
    • DOI: 10.1038/s41598-020-78835-9

    2 Insights on

    • Reduced Abdominal Fat
    • Reduced Oxidative Stress

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Lactobacillus brevis CD2 attenuates traumatic oral lesions induced by fixed orthodontic appliance: A randomized phase 2 trial.

    • 2020-12-14
    • RCT · n = 20
    • Orthodontics & Craniofacial Research 24(3)
    • • Nathália Louize Nunes Vieira Silva
      • Á. Della Bona
      • M. Cardoso
      • S. Callegari-Jacques
      • F. Fornari

    • PubMed: 33259688
    • DOI: 10.1111/ocr.12448

    4 Insights on

    • Improved Quality of Life
    • Reduced Duration of Traumatic Oral Lesions
    • Reduced Oral Pain
    • Reduced Oral Health-Related Quality of Life

    • High evidence
• December 15

  • Streptococcus thermophilus Attenuates Inflammation in Septic Mice Mediated by Gut Microbiota

    • 2020-12-15
    • Clinical Trial
    • Frontiers in Microbiology 11
    • • F. Han
      • Gaofeng Wu
      • Yijie Zhang
      • Haotian Zheng
      • Shichao Han
      • Xiao-qiang Li
      • W. Cai
      • Jiaqi Liu
      • Wanfu Zhang
      • Xiaowei Zhang
      • D. Hu

    • PubMed: 33384671
    • DOI: 10.3389/fmicb.2020.598010

    3 Insights on

    • Reduced Inflammation Levels
    • Improved Microbial Diversity
    • Inflammatory Disease Protection

    • Low evidence
    • Animal Study
• December 16

  • Lactobacillus salivarius, a Potential Probiotic to Improve the Health of LPS-Challenged Piglet Intestine by Alleviating Inflammation as Well as Oxidative Stress in a Dose-Dependent Manner During Weaning Transition

    • 2020-12-16
    • RCT · n = 72
    • Frontiers in Veterinary Science 7
    • • Zeyang Sun
      • Haihua Li
      • Yupeng Li
      • J. Qiao

    • PubMed: 33392276
    • DOI: 10.3389/fvets.2020.547425

    22 Insights on

    • Reduced Interleukin-6 Levels
    • Improved Intestinal Barrier Function
    • Increased Anti-Inflammatory Cytokine Levels
    • Reduced Pro-Inflammatory Cytokines
    • Reduced Diarrhea Incidence
    • Reduced Inflammatory Response
    • Reduced Diarrhea Rate
    • Increased Antioxidant Enzyme Levels
    • Regulated Immune Response
    • Improved Growth Performance
    • Increased Tight Junction Protein Levels
    • Reduced Pro-Inflammatory Mediator Production
    • Reduced Proinflammatory Mediators
    • Improved Antioxidant Enzyme Levels
    • Increased Expression of Oxidation-Related Gene
    • Increased Anti-inflammatory Cytokines
    • Enhanced Antioxidant Activity
    • Reduced Serum D-Lactate Levels
    • Regulated Oxidative Stress
    • Increased Tight Junction Proteins (Claudin-1)
    • Reduced Levels of Pro-Inflammatory Cytokines (IL-1β, IL-6, IFN-γ, TNF-α)
    • Reduced Pro-inflammatory Mediator Levels

    • Low evidence
    • Animal Study

  • Effect of Kefir on Soybean Isoflavone Aglycone Content in Soymilk Kefir

    • 2020-12-16
    • Frontiers in Nutrition 7
    • • Minke Yang
      • Xiaojuan Yang
      • Xiaoqu Chen
      • Jie Wang
      • Zhenlin Liao
      • Li Wang
      • Qingping Zhong
      • Xiang Fang

    • PubMed: 33392237
    • DOI: 10.3389/fnut.2020.587665

    1 Insight on

    • Improved Isoflavone Biotransformation

    • Low evidence
• December 17

  • Eukaryotic and Prokaryotic Microbiota Interactions.

    • 2020-12-17
    • Review
    • Microorganisms 8(12)
    • • Aly Kodio
      • Estelle Menu
      • Stéphane Ranque

    • PubMed: 33348551
    • DOI: 10.3390/microorganisms8122018

    2 Insights on

    • Improved Overall Health Status
    • Improved Glycemia

    • Low evidence

  • Feeding Limosilactobacillus fermentum K9-2 and Lacticaseibacillus casei K9-1, or Limosilactobacillus reuteri TMW1.656 Reduces Pathogen Load in Weanling Pigs

    • 2020-12-17
    • Clinical Trial
    • Frontiers in Microbiology 11
    • • Weilan Wang
      • R. Zijlstra
      • M. Gänzle

    • PubMed: 33391231
    • DOI: 10.3389/fmicb.2020.608293

    1 Insight on

    • Reduced Enterotoxigenic Escherichia coli Abundance

    • Low evidence
    • Animal Study
• December 19

  • Passiflora incarnata in Neuropsychiatric Disorders-A Systematic Review.

    • 2020-12-19
    • Systematic Review
    • Nutrients 12(12)
    • • Katarzyna Janda
      • Karolina Wojtkowska
      • Karolina Jakubczyk
      • Justyna Antoniewicz
      • Karolina Skonieczna-Żydecka

    • PubMed: 33352740
    • DOI: 10.3390/nu12123894

    4 Insights on

    • Improved Attention Span
    • Reduced Anxiety
    • Improved Memory Function
    • Improved Sleep

    • High evidence
    • Rigorous Journal
• December 22

  • Lactobacillus plantarum KLDS1.0344 and Lactobacillus acidophilus KLDS1.0901 Mixture Prevents Chronic Alcoholic Liver Injury in Mice by Protecting the Intestinal Barrier and Regulating Gut Microbiota and Liver-Related Pathways.

    • 2020-12-22
    • Clinical Trial
    • Journal of Agricultural and Food Chemistry 69(1)
    • • Huizhen Li
      • Jialu Shi
      • Li Zhao
      • Jiaqi Guan
      • Fei Liu
      • G. Huo
      • Bailiang Li

    • PubMed: 33353302
    • DOI: 10.1021/acs.jafc.0c06346

    12 Insights on

    • Reduced Liver Inflammation
    • Reduced Hepatic Oxidative Stress
    • Reduced Liver Lipid Accumulation
    • Reduced Inflammation Levels
    • Reduced Gram-Negative Bacteria Count
    • Increased Short-Chain Fatty Acid Production
    • Reduced Plasma Lipopolysaccharide Levels
    • Increased Short Chain Fatty Acids (SCFAs) Levels
    • Improved Intestinal Epithelial Permeability
    • Reduced Alcohol-Induced Liver Lipid Accumulation
    • Reduced Alcohol-Induced Liver Oxidative Stress
    • Reduced Portal Vein LPS Levels

    • Low evidence
    • Animal Study

  • Efficacy of Lactiplantibacillus plantarum 299 and 299v against nosocomial oropharyngeal pathogens in vitro and as an oral prophylactic treatment in a randomized, controlled clinical trial

    • 2020-12-22
    • RCT
    • MicrobiologyOpen 10(1)
    • • A. Tranberg
      • Bengt Klarin
      • Julia Johansson
      • L. Påhlman

    • PubMed: 33350604
    • DOI: 10.1002/mbo3.1151

    3 Insights on

    • Reduced Pathogen Growth
    • Inhibition of Otitis Media Pathogens Growth
    • No Influence on Oropharyngeal Microbiota

    • High evidence
• December 23

  • Plasma Amino Acid Response to Whey Protein Ingestion Following 28 Days of Probiotic (Bacillus subtilis DE111) Supplementation in Active Men and Women

    • 2020-12-23
    • RCT · n = 22
    • Journal of Functional Morphology and Kinesiology 6(1)
    • • Jeremy R. Townsend
      • William C. Vantrease
      • Megan D Jones
      • Philip A. Sapp
      • Kent D. Johnson
      • Cheryle N. Beuning
      • Allison A. Haase
      • C. Boot

    • PubMed: 33462163
    • DOI: 10.3390/jfmk6010001

    1 Insight on

    • Unchanged Plasma Amino Acid Response

    • High evidence
• December 24

  • Comparative evaluation for thermostability and gastrointestinal survival of probiotic Bacillus coagulans MTCC 5856.

    • 2020-12-24
    • Bioscience, Biotechnology, and Biochemistry 85(4)
    • • M. Majeed
      • Shaheen Majeed
      • S. Arumugam
      • Furqan Ali
      • Kirankumar Beede

    • PubMed: 33580694
    • DOI: 10.1093/bbb/zbaa116

    3 Insights on

    • Improved Gastrointestinal Survival
    • Improved Thermal Stability of Exopolysaccharides
    • Maintained Cell Viability

    • Low evidence
• December 29

  • Evaluation of the Effect of Probiotic Bacillus coagulans Unique IS2 on Mutans Streptococci and Lactobacilli Levels in Saliva and Plaque: A Double-Blind, Randomized, Placebo-Controlled Study in Children

    • 2020-12-29
    • RCT · n = 48
    • International Journal of Dentistry 2020
    • • M. Ratna Sudha
      • J. Neelamraju
      • M. Surendra Reddy
      • Manoj Kumar

    • PubMed: 33456469
    • DOI: 10.1155/2020/8891708

    4 Insights on

    • Reduced Streptococcus Mutans Levels
    • Reduced Cariogenic Bacteria
    • Improved Oral Microbial Balance
    • Reduced Caries-Causing Lactobacilli Levels

    • High evidence
    • Rigorous Journal
• December 30

  • Probiogenomics Analysis of 97 Lactobacillus crispatus Strains as a Tool for the Identification of Promising Next-Generation Probiotics

    • 2020-12-30
    • Microorganisms 9(1)
    • • Federico Fontana
      • Giulia Alessandri
      • G. Lugli
      • Leonardo Mancabelli
      • G. Longhi
      • R. Anzalone
      • Alice Viappiani
      • M. Ventura
      • F. Turroni
      • C. Milani

    • PubMed: 33396617
    • DOI: 10.3390/microorganisms9010073

    1 Insight on

    • Increased Vaginal Lactobacilli Levels

    • Low evidence
    • Rigorous Journal

  • L-lysine therapy to control the clinical evolution of pityriasis rosea: Clinical case report and literature review.

    • 2020-12-30
    • Review
    • Dermatologic therapy 34(1)
    • • Maria Cristina Pedrazini
      • Francisco Carlos Groppo

    • PubMed: 33326128
    • DOI: 10.1111/dth.14679

    3 Insights on

    • Reduced New Lesion Formation
    • Improved Lesion Regression
    • Accelerated Lesion Repair

    • Low evidence
• December 31

  • Fermentative Foods: Microbiology, Biochemistry, Potential Human Health Benefits and Public Health Issues.

    • 2020-12-31
    • Review
    • Foods (Basel, Switzerland) 10(1)
    • • Chrysa Voidarou
      • Μaria Antoniadou
      • Georgios Rozos
      • Athina Tzora
      • Ioannis Skoufos
      • Theodoros Varzakas
      • Areti Lagiou
      • Eugenia Bezirtzoglou

    • PubMed: 33396397
    • DOI: 10.3390/foods10010069

    2 Insights on

    • Improved Gastrointestinal Health
    • Improved Immune Function

    • Low evidence
• Undated – 14 supplement studies

  • High protein yogurt with addition of Lactobacillus helveticus: Peptide profile and angiotensin-converting enzyme ACE-inhibitory activity.

    • 2020-12
    • Food Chemistry 333
    • • Flávia Giacometti Cavalheiro
      • Débora Parra Baptista
      • Bruno Domingues Galli
      • F. Negrão
      • Marcos Nogueira Eberlin
      • Mirna Lúcia Gigante

    • PubMed: 32659671
    • DOI: 10.1016/j.foodchem.2020.127482

    1 Insight on

    • Increased ACE Inhibitor Activity

    • Low evidence

  • Probiotic characteristics of Lactobacillus strains isolated from cheese and their antibacterial properties against gastrointestinal tract pathogens

    • 2020-12
    • Saudi Journal of Biological Sciences 27(12)
    • • Xiao Zhang
      • Galal Ali Esmail
      • Abdulaziz Fahad Alzeer
      • M. Valan Arasu
      • P. Vijayaraghavan
      • Ki Choon Choi
      • N. Abdullah Al-Dhabi

    • PubMed: 33304162
    • DOI: 10.1016/j.sjbs.2020.10.022

    2 Insights on

    • Reduced Intestinal Pathogens
    • Increased Production of Bioactive Metabolites

    • Low evidence

  • Effect of Lactobacillus rhamnosus on growth of Listeria monocytogenes and Staphylococcus aureus in a probiotic Minas Frescal cheese.

    • 2020-12
    • Food Microbiology 92
    • • L. Prezzi
      • S. Lee
      • V. M. Nunes
      • C. Corassin
      • T. C. Pimentel
      • R. Rocha
      • G. L. Ramos
      • J. Guimarães
      • C. Balthazar
      • M. Duarte
      • M. Q. Freitas
      • E. Esmerino
      • M. C. Silva
      • A. Cruz
      • C. Oliveira

    • PubMed: 32950151
    • DOI: 10.1016/j.fm.2020.103557

    2 Insights on

    • Reduced Risk of Listeria Monocytogenes Infection
    • No Effect on Staphylococcus aureus

    • Low evidence

  • Lactobacillus reuteri DSM 17938 is effective in the treatment of functional abdominal pain in children: Results of the double-blind randomized study.

    • 2020-12
    • RCT · n = 147
    • Clinical Nutrition 39(12)
    • • O. Jadrešin
      • Sara Sila
      • I. Trivić
      • Z. Mišak
      • S. Kolaček
      • I. Hojsak

    • PubMed: 32362486
    • DOI: 10.1016/j.clnu.2020.04.019

    7 Insights on

    • Reduced Abdominal Pain Severity
    • Reduced Abdominal Pain
    • Reduced Pain Intensity
    • Increased Pain-Free Days
    • Reduced Abdominal Pain Intensity
    • No Change in Complete Symptom Cessation
    • Achieved Complete Symptom Cessation

    • High evidence

  • Effects of Bacillus subtilis on growth performance, serum parameters, digestive enzyme, intestinal morphology, and colonic microbiota in piglets

    • 2020-12
    • RCT · n = 72
    • AMB Express 10(1)
    • • B. Deng
      • Jie Wu
      • Xiaohui Li
      • Cheng Zhang
      • X. Men
      • Ziwei Xu

    • PubMed: 33263814
    • DOI: 10.1186/s13568-020-01150-z

    12 Insights on

    • Improved Gastrointestinal Health
    • Improved Intestinal Morphology
    • Improved Blood Glucose Levels
    • Improved Growth Performance
    • Enhanced Digestive Enzyme Activity
    • Improved Intestinal Villus Height
    • Increased Blood Glucose Levels
    • Increased Serum Glucose Levels
    • Modulated Colonic Microbiota
    • Improved Serum Parameters
    • Improved Digestive Enzyme Activity
    • Increased Serum Triglycerides

    • Low evidence
    • Animal Study

  • Fermented milk containing a potential probiotic Lactobacillus rhamnosus SD11 with maltitol reduces Streptococcus mutans: A double-blind, randomized, controlled study

    • 2020-12
    • RCT · n = 123
    • Journal of Dental Sciences 15(4)
    • • Nuntiya Pahumunto
      • S. Piwat
      • S. Chanvitan
      • Wiboon Ongwande
      • Supansa Uraipan
      • R. Teanpaisan

    • PubMed: 33505609
    • DOI: 10.1016/j.jds.2020.03.003

    3 Insights on

    • Reduced Salivary Levels of Mutans Streptococci
    • Increased Salivary Lactobacilli Levels
    • Reduced Streptococcus Mutans Levels

    • High evidence
    • Rigorous Journal

  • Dietary supplementation with L-carnosine improves patient-reported outcomes, autonomic nervous system performance, and brain metabolism in 3 adult patients with multiple sclerosis.

    • 2020-12
    • Clinical Trial
    • Nutrition research (New York, N.Y.) 84
    • • Dragana Zanini
      • Tatjana Jezdimirovic
      • Valdemar Stajer
      • Jelena Ostojic
      • Nebojsa Maksimovic
      • Sergej M Ostojic

    • PubMed: 33189432
    • DOI: 10.1016/j.nutres.2020.09.008

    9 Insights on

    • Increased Antioxidant Enzyme Levels
    • Reduced Lactate Levels
    • Reduced Fatigue
    • Reduced Multiple Sclerosis Symptom Severity
    • Improved Walking Distance
    • Improved Autonomic Nervous System Function
    • Increased Brain Choline Level
    • Increased Brain Creatine Level
    • Increased Myo-Inositol Level

    • Moderate evidence

  • Evaluation of nebulized N-acetyl cysteine in outcome of esophageal atresia with tracheoesophegeal fistula.

    • 2020-12
    • Clinical Trial · n = 30
    • Journal of pediatric surgery 55(12)
    • • Gurmeet Singh
      • Anand Pandey
      • Gaurav Shandilya
      • Archika Gupta
      • J D Rawat
      • Ashish Wakhlu
      • S N Kureel

    • PubMed: 32467034
    • DOI: 10.1016/j.jpedsurg.2020.04.013

    3 Insights on

    • Reduced Mortality Risk
    • Reduced Length of Hospital Stay
    • Reduced Secretion Consistency

    • High evidence

  • Impact of encapsulating a probiotic (Pediococcus pentosaceus Li05) within gastro-responsive microgels on Clostridium difficile infections.

    • 2021
    • Clinical Trial
    • Food & Function 12(7)
    • • Jiaojiao Xie
      • Mingfei Yao
      • Yanmeng Lu
      • Mengjia Yu
      • Shengyi Han
      • D. Mcclements
      • Hang Xiao
      • Lanjuan Li

    • PubMed: 33734244
    • DOI: 10.1039/d0fo03235b

    5 Insights on

    • Reduced Pro-inflammatory Cytokine Levels
    • Improved Colonic Histopathology
    • Reduced Clostridium difficile Infection
    • Improved Microbial Diversity
    • Improved Colonic Histology

    • Low evidence
    • Animal Study

  • Lactobacillus fermentum CQPC08 protects rats from lead-induced oxidative damage by regulating the Keap1/Nrf2/ARE pathway.

    • 2021
    • Clinical Trial
    • Food & Function 12(13)
    • • X. Long
      • F. Sun
      • Zhiying Wang
      • Tongjin Liu
      • Jianjun Gong
      • Xuemei Kan
      • Yujie Zou
      • Xin Zhao

    • PubMed: 34037025
    • DOI: 10.1039/d1fo00589h

    8 Insights on

    • Reduced Hepatic Oxidative Stress
    • Reduced Pro-inflammatory Cytokine Levels
    • Improved Inflammatory Response
    • Reduced Oxidative Stress
    • Enhanced Antioxidant Activity
    • Enhanced Antioxidant Enzyme Activity
    • Increased Lead Ion Adsorption
    • Reduced Tissue Lead Levels

    • Low evidence
    • Animal Study

  • Live and ultrasound-inactivated Lacticaseibacillus casei modulate the intestinal microbiota and improve biochemical and cardiovascular parameters in male rats fed a high-fat diet.

    • 2021
    • Clinical Trial · n = 24
    • Food & Function 12(12)
    • • Larissa Ramalho Brandão
      • J. L. de Brito Alves
      • W. K. A. da Costa
      • Georgianna de Araújo Henriques Ferreira
      • Matthaws Pereira de Oliveira
      • A. Gomes da Cruz
      • V. Braga
      • J. Aquino
      • H. Vidal
      • M. F. Noronha
      • Lucélia Cabral
      • T. C. Pimentel
      • M. Magnani

    • PubMed: 34009228
    • DOI: 10.1039/d1fo01064f

    9 Insights on

    • Improved Insulin Sensitivity
    • Reduced Total Cholesterol Levels
    • Reduced Blood Pressure
    • Increased Beneficial Gut Microbiota
    • Increased HDL Cholesterol Levels
    • Reduced Harmful Gut Bacteria
    • Enhanced Beneficial Bacteria in Intestinal Microbiota
    • Reduced Harmful Bacteria in Intestinal Microbiota
    • Attenuated Blood Pressure (Inactivated Cells Only)

    • Low evidence
    • Animal Study

  • Probiotics in irritable bowel syndrome - is the quest for the right strain over? Rapid review of existing guidelines and recommendations.

    • 2021
    • Review
    • Przeglad gastroenterologiczny 16(4)
    • • Wojciech Marlicz
      • Karolina Skonieczna-Żydecka
      • Patrycja Krynicka
      • Igor Łoniewski
      • Grażyna Rydzewska

    • PubMed: 34976247
    • DOI: 10.5114/pg.2021.111766

    2 Insights on

    • Reduced Global Symptoms
    • Reduced Global Symptom Persistence

    • Low evidence

  • Potential prebiotic properties of exopolysaccharides produced by a novel Lactobacillus strain, Lactobacillus pentosus YY-112.

    • 2021
    • Food & Function 12(19)
    • • Mingzhe Wang
      • Wanyi Zhou
      • Ying Yang
      • Jianrong Xing
      • Xiaodan Xu
      • Yuqing Lin

    • PubMed: 34606528
    • DOI: 10.1039/d1fo01261d

    3 Insights on

    • Increased Short-Chain Fatty Acid Production
    • Reduced Acetate to Propionate Ratio
    • Improved Gut Microbiome Composition

    • Low evidence

  • Effects of Pediococcus pentosaceus LI05 on immunity and metabolism in germ-free rats.

    • 2021
    • Clinical Trial
    • Food & Function 12(11)
    • • Shiman Jiang
      • Jiafeng Xia
      • L. Lv
      • Qiangqiang Wang
      • Yating Li
      • Qiaomai Xu
      • Xiaoyuan Bian
      • Jianzhong Ye
      • Liya Yang
      • Huiyong Jiang
      • Ren Yan
      • Kaicen Wang
      • D. Fang
      • Lanjuan Li

    • PubMed: 33960989
    • DOI: 10.1039/d0fo02530e

    7 Insights on

    • Reduced Pro-Inflammatory Cytokines
    • Reduced Body Weight
    • Improved Immune Function
    • Improved Liver Function
    • Reduced Inflammation Levels
    • Improved Antimicrobial Ability
    • Increased Intestinal Subepidermal CD4+ Cell Levels

    • Low evidence
    • Animal Study