September 2023 Supplement Research Papers

• September 1

  • The effects of L-carnitine supplementation on inflammatory and anti-inflammatory markers in adults: a systematic review and dose-response meta-analysis.

    • 2023-09-01
    • Meta-Analysis · n = 3,255
    • Inflammopharmacology 31(5)
    • • Samira Rastgoo
      • Sahand Tehrani Fateh
      • Mahlagha Nikbaf-Shandiz
      • Niloufar Rasaei
      • Yasaman Aali
      • Mohammad Zamani
      • Farideh Shiraseb
      • Omid Asbaghi

    • PubMed: 37656233
    • DOI: 10.1007/s10787-023-01323-9

    7 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Interleukin-6 Levels
    • Reduced C-Reactive Protein Levels
    • Improved Total Antioxidant Capacity
    • Reduced Malondialdehyde
    • Reduced Aspartate Transaminase Level
    • Reduced Alanine Transaminase

    • High evidence

  • Fortification of condiments and seasonings with iron for preventing anaemia and improving health.

    • 2023-09-01
    • Meta-Analysis · n = 4,459
    • The Cochrane database of systematic reviews 2023(9)
    • • Chowdhury Sb Jalal
      • Luz Maria De-Regil
      • Vanessa Pike
      • Prasanna Mithra

    • PubMed: 37665781
    • DOI: 10.1002/14651858.cd009604.pub2

    4 Insights on

    • Increased Hemoglobin Levels
    • Increased Ferritin Level
    • Reduced Iron Deficiency
    • Reduced Anemia

    • High evidence

  • Screening of Potential Probiotic Lactobacillaceae and Their Improvement of Type 2 Diabetes Mellitus by Promoting PI3K/AKT Signaling Pathway in db/db Mice.

    • 2023-09-01
    • Polish journal of microbiology 72(3)
    • • Yueyang Li
      • Tong Tong
      • Peifan Li
      • Yian Peng
      • Michael Zhang
      • Jia Liu
      • Yongxin She
      • Zuming Li
      • Yongli Li

    • PubMed: 37725896
    • DOI: 10.33073/pjm-2023-028

    5 Insights on

    • Increased Short-Chain Fatty Acid Production
    • Improved Glycemic Control
    • Reduced Inflammation
    • Improved Liver Histology
    • Improved Glycemia

    • Low evidence
• September 4

  • Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis.

    • 2023-09-04
    • Systematic Review · n = 9,253
    • Nutrients 15(17)
    • • Peiwei Xie
      • Mei Luo
      • Xuehong Deng
      • Jiahui Fan
      • Lishou Xiong

    • PubMed: 37686889
    • DOI: 10.3390/nu15173856

    1 Insight on

    • Reduced Abdominal Pain

    • High evidence
    • Rigorous Journal

  • The effect of L-carnitine supplementation on lipid profile in adults: an umbrella meta-analysis on interventional meta-analyses.

    • 2023-09-04
    • Systematic Review
    • Frontiers in nutrition 10
    • • Vali Musazadeh
      • Hanie Alinejad
      • Niloofar Kouhi Esfahani
      • Zeynab Kavyani
      • Majid Keramati
      • Neda Roshanravan
      • Erfan Mosharkesh
      • Parvin Dehghan

    • PubMed: 37727632
    • DOI: 10.3389/fnut.2023.1214734

    4 Insights on

    • Reduced Low-Density Lipoprotein Level
    • Reduced Triglyceride Levels
    • Increased HDL Cholesterol Levels
    • Reduced Total Cholesterol

    • High evidence
• September 5

  • Selenium in Prostate Cancer: Prevention, Progression, and Treatment.

    • 2023-09-05
    • Review
    • Pharmaceuticals (Basel, Switzerland) 16(9)
    • • Jinjiang Jiang
      • Bo Chen
      • Bo Tang
      • Qiang Wei

    • PubMed: 37765058
    • DOI: 10.3390/ph16091250

    1 Insight on

    • Reduced Prostate Cancer Incidence

    • Low evidence
• September 6

  • L-Carnitine and Male Fertility: Is Supplementation Beneficial?

    • 2023-09-06
    • Review
    • Journal of clinical medicine 12(18)
    • • Filipa G Mateus
      • Silvia Moreira
      • Ana D Martins
      • Pedro F Oliveira
      • Marco G Alves
      • Maria de Lourdes Pereira

    • PubMed: 37762736
    • DOI: 10.3390/jcm12185796

    4 Insights on

    • Improved Sperm Quality
    • Reduced Reactive Oxygen Species Level
    • Regulated Hormone Level
    • Improved Fertility Rate

    • Low evidence

  • Antigingivitis and Antiplaque Effects of Oral Probiotic Containing the Streptococcus salivarius M18 Strain: A Randomized Clinical Trial

    • 2023-09-06
    • RCT · n = 61
    • Nutrients 15(18)
    • • K. Babina
      • Dilara Salikhova
      • V. Doroshina
      • Irina Makeeva
      • A. Zaytsev
      • Matvey Uvarichev
      • M. Polyakova
      • N. Novozhilova

    • PubMed: 37764667
    • DOI: 10.3390/nu15183882

    7 Insights on

    • Reduced Gingival Bleeding
    • Improved Gingival Health
    • Reduced Plaque Levels
    • Improved Gingival Bleeding
    • Reduced Gingival Index
    • Reduced Plaque Index
    • Reduced Gingival Bleeding Index

    • High evidence
• September 7

  • Assessment of beneficial effects and identification of host adaptation-associated genes of Ligilactobacillus salivarius isolated from badgers.

    • 2023-09-07
    • BMC genomics 24(1)
    • • Yu Wang
      • Xiaomeng Xu
      • Huan Chen
      • Fang Yang
      • Bo Xu
      • Kun Wang
      • Qianwen Liu
      • Guixin Liang
      • Ruiqi Zhang
      • Xin'an Jiao
      • Yunzeng Zhang

    • PubMed: 37679681
    • DOI: 10.1186/s12864-023-09623-8

    3 Insights on

    • Increased Fiber Carbohydrate Degradation Rate
    • Improved Digestive Function
    • Improved Probiotic Potential

    • Low evidence
• September 11

  • Bioactive Properties, Bioavailability Profiles, and Clinical Evidence of the Potential Benefits of Black Pepper (Piper nigrum) and Red Pepper (Capsicum annum) against Diverse Metabolic Complications.

    • 2023-09-11
    • Review
    • Molecules (Basel, Switzerland) 28(18)
    • • Phiwayinkosi V Dludla
      • Ilenia Cirilli
      • Fabio Marcheggiani
      • Sonia Silvestri
      • Patrick Orlando
      • Ndivhuwo Muvhulawa
      • Marakiya T Moetlediwa
      • Bongani B Nkambule
      • Sithandiwe E Mazibuko-Mbeje
      • Nokulunga Hlengwa
      • Sidney Hanser
      • Duduzile Ndwandwe
      • Jeanine L Marnewick
      • Albertus K Basson
      • Luca Tiano

    • PubMed: 37764345
    • DOI: 10.3390/molecules28186569

    1 Insight on

    • Reduced Body Fat Mass

    • Low evidence

  • Can vitamin B6 alleviate the adverse reactions of quadruple anti-Helicobacter pylori regimen? : randomized controlled trial.

    • 2023-09-11
    • RCT · n = 280
    • BMC infectious diseases 23(1)
    • • Meng-Yan Cui
      • Meng-Jie Zhang
      • Qiao-Li Jiang
      • Zhong-Mei Pei
      • Zhen-Yu Cui
      • Mei Kang
      • Lun-Gen Lu
      • Ying-Ying Lu

    • PubMed: 37697258
    • DOI: 10.1186/s12879-023-08571-8

    3 Insights on

    • Reduced Adverse Reaction
    • Reduced Central Nervous System Symptom Severity
    • Reduced Gastrointestinal Symptom Severity

    • High evidence
    • Large Human Trial
• September 14

  • Efficacy and safety of Lacticaseibacillus rhamnosus R0011 and Lactobacillus helveticus R0052 as an adjuvant for Helicobacter pylori eradication: a double-blind, randomized, placebo-controlled study.

    • 2023-09-14
    • RCT · n = 160
    • Frontiers in gastroenterology (Lausanne, Switzerland) 2
    • • Anya Kiattiweerasak
      • Natsuda Aumpan
      • Soonthorn Chonprasertsuk
      • Bubpha Pornthisarn
      • Sith Siramolpiwat
      • Patommatat Bhanthumkomol
      • Pongjarat Nunanan
      • Navapan Issariyakulkarn
      • Varocha Mahachai
      • Yoshio Yamaoka
      • Ratha-Korn Vilaichone

    • PubMed: 41821821
    • DOI: 10.3389/fgstr.2023.1245993

    4 Insights on

    • Improved Health-related Quality of Life
    • Improved H Pylori Eradication Rates
    • Reduced Severity of Gastrointestinal Disorders
    • Reduced Gastrointestinal Adverse Events

    • High evidence
• September 15

  • The Intestinal Microbiota in the Development of Chronic Liver Disease: Current Status.

    • 2023-09-15
    • Review
    • Diagnostics (Basel, Switzerland) 13(18)
    • • Josip Stojic
      • Michał Kukla
      • Ivica Grgurevic

    • PubMed: 37761327
    • DOI: 10.3390/diagnostics13182960

    1 Insight on

    • Improved Liver Function

    • Low evidence
• September 18

  • Intranasally inoculated bacterium-like particles displaying porcine epidemic diarrhea virus S1 protein induced intestinal mucosal immune response in mice.

    • 2023-09-18
    • Frontiers in immunology 14
    • • Kai Su
      • Yawen Wang
      • Chen Yuan
      • Yanan Zhang
      • Yanrui Li
      • Tanqing Li
      • Qinye Song

    • PubMed: 37790942
    • DOI: 10.3389/fimmu.2023.1269409

    3 Insights on

    • Increased Cytokine Response
    • Increased Intestinal Mucosal Immune Response
    • Increased Antibody Response

    • Low evidence
    • Animal Study

  • Anaerobutyricum hallii promotes the functional depletion of a food carcinogen in diverse healthy fecal microbiota.

    • 2023-09-18
    • Clinical Trial
    • Frontiers in microbiomes 2
    • • Alejandro Ramirez Garcia
      • Anna Greppi
      • Florentin Constancias
      • Hans-Joachim Ruscheweyh
      • Julie Gasser
      • Katherine Hurley
      • Shana J Sturla
      • Clarissa Schwab
      • Christophe Lacroix

    • PubMed: 41853383
    • DOI: 10.3389/frmbi.2023.1194516

    2 Insights on

    • Reduced Short-Chain Fatty Acid Levels in Feces
    • Reduced PhIP Exposure

    • Moderate evidence
• September 22

  • Ameliorating Effects of Bifidobacterium longum subsp. infantis FB3-14 against High-Fat-Diet-Induced Obesity and Gut Microbiota Disorder

    • 2023-09-22
    • Clinical Trial
    • Nutrients 15(19)
    • • Ruixin Kou
      • Jin Wang
      • Angyang Li
      • Yuanyifei Wang
      • Bowei Zhang
      • Jingming Liu
      • Ying Sun
      • Shuo Wang

    • PubMed: 37836387
    • DOI: 10.3390/nu15194104

    5 Insights on

    • Reduced Inflammation Levels
    • Reduced Adipocyte Size
    • Reduced Liver Injury
    • Normalized Serum Lipid Levels
    • Restored Lipid Metabolism

    • Low evidence
    • Animal Study
• September 23

  • Characterization of Lactobacilli Phage Endolysins and Their Functional Domains-Potential Live Biotherapeutic Testing Reagents.

    • 2023-09-23
    • Viruses 15(10)
    • • Robert J Dorosky
      • Stephanie L Lola
      • Haleigh A Brown
      • Jeremy E Schreier
      • Sheila M Dreher-Lesnick
      • Scott Stibitz

    • PubMed: 37896764
    • DOI: 10.3390/v15101986

    1 Insight on

    • Improved Live Biotherapeutic Product Potency and Purity Testing Reagents

    • Low evidence

  • Interactive Effect of Dietary Heat-Killed Lactobacillus Plantarum L-137 and Berberine Supplementation on Intestinal Mucosa and Microbiota of Juvenile Black Sea Bream (Acanthopagrus Schlegelii).

    • 2023-09-23
    • Probiotics and antimicrobial proteins 17(1)
    • • Gladstone Sagada
      • Lei Wang
      • Bingying Xu
      • Yuxiao Sun
      • Qingjun Shao

    • PubMed: 37740880
    • DOI: 10.1007/s12602-023-10153-8

    3 Insights on

    • Improved Gut Microbiota Composition
    • Improved Intestinal Barrier Function
    • Improved Intestinal Morphology

    • Low evidence
    • Rigorous Journal
    • Animal Study
• September 26

  • Interplay between inflammatory bowel disease therapeutics and the gut microbiome reveals opportunities for novel treatment approaches.

    • 2023-09-26
    • Review
    • Microbiome research reports 2(4)
    • • Catherine O'Reilly
      • Susan Mills
      • Mary C Rea
      • Aonghus Lavelle
      • Subrata Ghosh
      • Colin Hill
      • R Paul Ross

    • PubMed: 37849974
    • DOI: 10.20517/mrr.2023.41

    3 Insights on

    • Improved Gut Microbiome Composition
    • Improved Effectiveness in Inflammatory Bowel Disease
    • Microbiome Biomarker of Treatment Response

    • Low evidence
• September 28

  • Human gut microbiome: Therapeutic opportunities for metabolic syndrome-Hype or hope?

    • 2023-09-28
    • Review
    • Endocrinology, diabetes & metabolism 7(1)
    • • Angela Horvath
      • Kristina Zukauskaite
      • Olha Hazia
      • Irina Balazs
      • Vanessa Stadlbauer

    • PubMed: 37771199
    • DOI: 10.1002/edm2.436

    2 Insights on

    • Improved Metabolic Health
    • No Human Health Outcome Reported

    • Low evidence

  • Three Strains of Lactobacillus Derived from Piglets Alleviated Intestinal Oxidative Stress Induced by Diquat through Extracellular Vesicles.

    • 2023-09-28
    • Nutrients 15(19)
    • • Shengkai Feng
      • Yihan Liu
      • Jing Xu
      • Jinping Fan
      • Jingjing Li
      • Zhifeng Wu
      • Yue Sun
      • Wen Xiong

    • PubMed: 37836484
    • DOI: 10.3390/nu15194198

    3 Insights on

    • Improved Gut Microbiota Composition
    • Improved Intestinal Barrier Function
    • Reduced Oxidative Stress in Intestinal Epithelial Cells

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Probiotic properties of Bacillus subtilis DG101 isolated from the traditional Japanese fermented food nattō

    • 2023-09-28
    • Frontiers in Microbiology 14
    • • Cecilia Leñini
      • Facundo Rodriguez Ayala
      • Anibal Juan Goñi
      • Liliana Rateni
      • Akira Nakamura
      • R. Grau

    • PubMed: 37840737
    • DOI: 10.3389/fmicb.2023.1253480

    6 Insights on

    • Reduced Blood Pressure
    • Extended Lifespan
    • Osteoporosis Prevention
    • Reduced Incidence of Cardiovascular Disease
    • Improved Lipid Serum Homeostasis
    • Improved Serum Protein Homeostasis

    • Low evidence
• September 29

  • L. barbarum (Lycium barbarum L.) supplementation for lipid profiles in adults: A systematic review and meta-analysis of RCTs.

    • 2023-09-29
    • Meta-Analysis · n = 259
    • Medicine 102(39)
    • • Xueyuan Zeng
      • Weimin Zhao
      • Siming Wang
      • Huazhong Xiong
      • Junliang Wu
      • Jixiang Ren

    • PubMed: 37773857
    • DOI: 10.1097/md.0000000000034952

    4 Insights on

    • Reduced Triglyceride Levels
    • Reduced LDL Cholesterol
    • Reduced Total Cholesterol
    • Increased High-Density Lipoprotein Cholesterol

    • High evidence

  • Effectiveness of Fish Roe, Snow Fungus, and Yeast Supplementation for Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

    • 2023-09-29
    • RCT
    • Nutrients 15(19)
    • • Yung-Kai Lin
      • Yung-Hsiang Lin
      • Chi-Fu Chiang
      • Li Jingling

    • PubMed: 37836504
    • DOI: 10.3390/nu15194221

    7 Insights on

    • Improved Quality of Life
    • Improved Delayed Memory
    • Reduced Anxiety
    • Improved Reaction Time
    • Reduced Fatigue
    • Improved Recognition Memory
    • Improved Emotional Processing

    • High evidence
    • Rigorous Journal
• Undated – 2 supplement studies

  • Supplements Are Not a Synonym for Safe: Suspected Liver Injury From Ashwagandha.

    • 2023-09
    • Case Report
    • Federal practitioner : for the health care professionals of the VA, DoD, and PHS 40(9)
    • • Sondra Vazirani
      • Amit Kothari
      • Jeffrey Fujimoto
      • Mariana Gomez

    • PubMed: 38562158
    • DOI: 10.12788/fp.0409

    1 Insight on

    • Reduced Cholestatic Pattern of Liver Injury

    • Low evidence

  • Vaginal colonization of women after oral administration of Lactobacillus crispatus strain NTCVAG04 from the human microbiota.

    • 2023-09
    • Clinical Trial · n = 20
    • Minerva Obstetrics and Gynecology 75(5)
    • • V. de Leo
      • Elisa Lazzeri
      • L. Governini
      • A. M. Cuppone
      • Lorenzo Colombini
      • Lucia Teodori
      • G. Ciprandi
      • F. Iannelli
      • G. Pozzi

    • PubMed: 35686637
    • DOI: 10.23736/S2724-606X.22.05087-4

    1 Insight on

    • Reduced Vaginal Colonization of Pathogenic Bacteria

    • Moderate evidence