April 2021 Supplement Research Papers

• April 1

  • Bacteriocins from Lactic Acid Bacteria. A Powerful Alternative as Antimicrobials, Probiotics, and Immunomodulators in Veterinary Medicine.

    • 2021-04-01
    • Review
    • Animals : an open access journal from MDPI 11(4)
    • • Juan Carlos Hernández-González
      • Abigail Martínez-Tapia
      • Gebim Lazcano-Hernández
      • Blanca Estela García-Pérez
      • Nayeli Shantal Castrejón-Jiménez

    • PubMed: 33915717
    • DOI: 10.3390/ani11040979

    5 Insights on

    • Improved Gastrointestinal Health
    • Improved Immune Function
    • Improved Immune Response
    • Reduced Pathogen Colonization
    • Reduced Risk of Infection

    • Moderate evidence
    • Highly Cited

  • A multicenter clinical study with myo-inositol and alpha-lactalbumin in Mexican and Italian PCOS patients.

    • 2021-04-01
    • Clinical Trial
    • European review for medical and pharmacological sciences 25(8)
    • • I Hernandez Marin
      • O Picconi
      • A S Laganà
      • L Costabile
      • V Unfer

    • PubMed: 33928619
    • DOI: 10.26355/eurrev_202104_25743

    4 Insights on

    • Improved Insulin Sensitivity
    • Reduced HOMA Index
    • Reduced Luteinizing Hormone Level
    • Reduced Androstenedione Level

    • Moderate evidence

  • Orange Juice and Yogurt Carrying Probiotic Bacillus coagulans GBI-30 6086: Impact of Intake on Wistar Male Rats Health Parameters and Gut Bacterial Diversity

    • 2021-04-01
    • RCT · n = 48
    • Frontiers in Microbiology 12
    • • Carine N. Almada-Érix
      • C. N. Almada
      • Lucélia Cabral
      • Viviane Priscila Barros de Medeiros
      • A. R. Roquetto
      • V. A. Santos-Junior
      • M. Fontes
      • A. E. S. S. Gonçalves
      • Andrey Dos Santos
      • P. Lollo
      • M. Magnani
      • A. Sant’Ana

    • PubMed: 34135869
    • DOI: 10.3389/fmicb.2021.623951

    7 Insights on

    • Reduced Triglyceride Levels
    • Improved Blood Glucose Levels
    • Reduced Serum Glucose Levels
    • Lower Plasma Glucose Levels
    • Improved Gut Bacterial Diversity
    • Increased Abundance of Gut Bacteria
    • Increased Abundance of Specific Bacterial Species

    • Low evidence
    • Animal Study

  • Identification of the effects of acid-resistant Lactobacillus casei metallopeptidase gene under colon-specific promoter on the colorectal and breast cancer cell lines.

    • 2021-04-01
    • Iranian journal of basic medical sciences 24(4)
    • • Narges Dadfarma
      • Jamileh Nowroozi
      • Bahram Kazemi
      • Mojgan Bandehpour

    • PubMed: 34094033
    • DOI: 10.22038/ijbms.2021.53015.11950

    1 Insight on

    • Increased Apoptosis

    • Low evidence

  • Effect of Lactobacillus reuteri LRE02-Lactobacillus rhamnosus LR04 combination and gastrointestinal functional disorders in an Emergency Department pediatric population.

    • 2021-04-01
    • Observational
    • European review for medical and pharmacological sciences 25(7)
    • • G Margiotta
      • S Ferretti
      • B Graglia
      • A Gatto
      • L Capossela
      • G Bersani
      • A Curatola
      • A Chiaretti

    • PubMed: 33877678
    • DOI: 10.26355/eurrev_202104_25564

    2 Insights on

    • Improved Gastrointestinal Symptoms
    • Improved Stool Formation

    • Low evidence
• April 5

  • Evaluation of High-Intensity Interval Training and Beta-Alanine Supplementation on Efficiency of Electrical Activity and Electromyographic Fatigue Threshold.

    • 2021-04-05
    • RCT
    • Journal of strength and conditioning research 35(6)
    • • Ashley A Herda
      • Abbie E Smith-Ryan
      • Kristina L Kendall
      • Joel T Cramer
      • Jeffrey R Stout

    • PubMed: 34027920
    • DOI: 10.1519/jsc.0000000000004038

    2 Insights on

    • Improved Fatigue Threshold
    • Improved Efficiency of Electrical Activity

    • High evidence
• April 7

  • Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review.

    • 2021-04-07
    • Systematic Review
    • BMC complementary medicine and therapies 21(1)
    • • L Susan Wieland
      • Vanessa Piechotta
      • Termeh Feinberg
      • Emilie Ludeman
      • Brian Hutton
      • Salmaan Kanji
      • Dugald Seely
      • Chantelle Garritty

    • PubMed: 33827515
    • DOI: 10.1186/s12906-021-03283-5

    6 Insights on

    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Risk of Common Cold
    • Reduced Cold Duration
    • Reduced Cold Severity
    • Reduced Influenza Duration
    • Reduced Cytokine Level

    • High evidence

  • Colonization of Supplemented Bifidobacterium breve M-16V in Low Birth Weight Infants and Its Effects on Their Gut Microbiota Weeks Post-administration

    • 2021-04-07
    • RCT · n = 22
    • Frontiers in Microbiology 12
    • • A. Horigome
      • K. Hisata
      • T. Odamaki
      • N. Iwabuchi
      • J. Xiao
      • Toshiaki Shimizu

    • PubMed: 33897631
    • DOI: 10.3389/fmicb.2021.610080

    9 Insights on

    • Improved Gut Microbiota
    • Improved Gut Microbiome Composition
    • Increased Beneficial Gut Bacteria
    • Increased Levels of Actinobacteria
    • Reduced Abundance of Proteobacteria
    • Increased Indigenous Bifidobacterium Levels
    • Increased Bifidobacterium Levels
    • Increased Colonization by Administered Strain
    • Increased Beneficial Bacterial Colonization

    • High evidence
• April 8

  • Oral intake of Lactobacillus plantarum L‐14 extract alleviates TLR2‐ and AMPK‐mediated obesity‐associated disorders in high‐fat‐diet‐induced obese C57BL/6J mice

    • 2021-04-08
    • Clinical Trial
    • Cell Proliferation 54(6)
    • • Jaehoon Lee
      • Sangkyu Park
      • Naeun Oh
      • Jaehyun Park
      • Mijin Kwon
      • Jeongmin Seo
      • S. Roh

    • PubMed: 33830560
    • DOI: 10.1111/cpr.13039

    7 Insights on

    • Improved Insulin Sensitivity
    • Reduced Body Weight
    • Reduced Hepatic Steatosis
    • Reduced Liver Fat
    • Reduced Adipogenesis
    • Reduced Weight Gain
    • Reduced Steatohepatitis

    • Low evidence
    • Animal Study
• April 12

  • Improvement of Myelopoiesis in Cyclophosphamide-Immunosuppressed Mice by Oral Administration of Viable or Non-Viable Lactobacillus Strains.

    • 2021-04-12
    • Frontiers in immunology 12
    • • Andrés Gramajo Lopez
      • Florencia Gutiérrez
      • Lucila Saavedra
      • Elvira Maria Hebert
      • Susana Alvarez
      • Susana Salva

    • PubMed: 33912172
    • DOI: 10.3389/fimmu.2021.647049

    2 Insights on

    • Accelerated Recovery of Chemotherapy-Induced Myelosuppression
    • Increased Bone Marrow Myelopoiesis

    • Low evidence
    • Animal Study

  • Limosilactobacillus reuteri ATCC PTA 5289 and DSM 17938 as adjuvants to improve evolution of pharyngitis/tonsillitis in children: randomised controlled trial.

    • 2021-04-12
    • RCT
    • Beneficial Microbes 12(2)
    • • A. Maya-Barrios
      • K. Lira-Hernandez
      • I. Jiménez-Escobar
      • L. Hernández
      • A. Ortiz-Hernández
      • C. Jiménez-Gutiérrez
      • G. López-Velázquez
      • P. Gutiérrez-Castrellón

    • PubMed: 33789556
    • DOI: 10.3920/BM2020.0171

    8 Insights on

    • Reduced TNF-α Levels
    • Reduced Fever
    • Reduced Sore Throat Severity
    • Reduced Days with Runny Nose Symptoms
    • Reduced Nasal Congestion
    • Reduced Non-Programmed Medical Visits
    • Reduced Treatment Costs
    • Similar Frequency of Adverse Events

    • High evidence

  • Drops of Lactiplantibacillus plantarum CRL 759 culture supernatant attenuates eyes inflammation induced by lipopolysaccharide.

    • 2021-04-12
    • Clinical Trial
    • Beneficial Microbes 12(2)
    • • B. I. Layús
      • M. Gómez
      • S. Cazorla
      • A. V. Rodriguez

    • PubMed: 33769229
    • DOI: 10.3920/BM2020.0101

    3 Insights on

    • Reduced Proinflammatory Cytokine Production
    • Reduced Ocular Inflammation
    • Reduced Inflammatory Markers in Aqueous Humour

    • Low evidence
    • Animal Study
• April 13

  • The effect of oat bran consumption on gestational diabetes: a randomized controlled clinical trial.

    • 2021-04-13
    • RCT · n = 112
    • BMC endocrine disorders 21(1)
    • • Zahra Barati
      • Mina Iravani
      • Majid Karandish
      • Mohammad Hosein Haghighizadeh
      • Sara Masihi

    • PubMed: 33849494
    • DOI: 10.1186/s12902-021-00731-8

    2 Insights on

    • Reduced Fasting Blood Glucose Levels
    • Reduced Two-Hour Postprandial Glucose

    • High evidence
    • Large Human Trial

  • Lactobacillus plantarum HFY09 alleviates alcohol-induced gastric ulcers in mice via an anti-oxidative mechanism.

    • 2021-04-13
    • Clinical Trial
    • Journal of Food Biochemistry 45(5)
    • • Ya Wu
      • Hong Chen
      • Yujie Zou
      • Ruokun Yi
      • Jianfei Mu
      • Xin Zhao

    • PubMed: 33846998
    • DOI: 10.1111/jfbc.13726

    4 Insights on

    • Reduced Hepatic Oxidative Stress
    • Reduced Inflammatory Response
    • Alleviated Alcohol-Induced Gastric Ulcers
    • Enhanced Gastric Mucosal Defense

    • Low evidence
    • Animal Study
• April 14

  • The Role of Bifidobacteria in Predictive and Preventive Medicine: A Focus on Eczema and Hypercholesterolemia

    • 2021-04-14
    • Microorganisms 9(4)
    • • L. Marras
      • M. Caputo
      • S. Bisicchia
      • Matteo Soato
      • G. Bertolino
      • S. Vaccaro
      • Rosanna Inturri

    • PubMed: 33919907
    • DOI: 10.3390/microorganisms9040836

    1 Insight on

    • Reduced Serum Cholesterol Levels

    • Low evidence
    • Rigorous Journal

  • Treatment with Bacterial Biologics Promotes Healthy Aging and Traumatic Brain Injury Responses in Adult Drosophila, Modeling the Gut-Brain Axis and Inflammation Responses.

    • 2021-04-14
    • Cells 10(4)
    • • Brandon Molina
      • Jessica Mastroianni
      • Ema Suarez
      • Brijinder Soni
      • Erica Forsberg
      • Kim Finley

    • PubMed: 33919883
    • DOI: 10.3390/cells10040900

    6 Insights on

    • Improved Motor Function
    • Improved Longevity
    • Reduced Neural Aggregation
    • Improved Response to Traumatic Brain Injury
    • Altered NF-kappaB Signaling
    • Reduced Severe Traumatic Brain Injury

    • Low evidence
    • Animal Study
• April 15

  • The effect of propolis plus Hyoscyamus niger L. methanolic extract on clinical symptoms in patients with acute respiratory syndrome suspected to COVID-19: A clinical trial.

    • 2021-04-15
    • RCT
    • Phytotherapy research : PTR 35(7)
    • • Morteza Kosari
      • Mehdi Noureddini
      • Seyed Peyman Khamechi
      • Ahmad Najafi
      • Amir Ghaderi
      • Mojtaba Sehat
      • Hamid Reza Banafshe

    • PubMed: 33860587
    • DOI: 10.1002/ptr.7116

    10 Insights on

    • Reduced Vomiting Frequency
    • Reduced Abdominal Pain
    • Reduced Fever
    • Reduced Diarrhea
    • Reduced Headache
    • Reduced Dry Cough
    • Reduced Shortness of Breath
    • Reduced Sore Throat
    • Reduced Chest Pain
    • Reduced Dizziness

    • High evidence

  • A Narrative Review on Dietary Strategies to Provide Nitric Oxide as a Non-Drug Cardiovascular Disease Therapy: Beetroot Formulations-A Smart Nutritional Intervention.

    • 2021-04-15
    • Review
    • Foods (Basel, Switzerland) 10(4)
    • • Diego Dos Santos Baião
      • Davi Vieira Teixeira da Silva
      • Vania Margaret Flosi Paschoalin

    • PubMed: 33920855
    • DOI: 10.3390/foods10040859

    1 Insight on

    • Reduced Blood Pressure

    • Low evidence

  • Probiotic Lactobacilli Isolated from Kefir Promote Down-Regulation of Inflammatory Lamina Propria T Cells from Patients with Active IBD

    • 2021-04-15
    • Frontiers in Pharmacology 12
    • • R. Curciarello
      • K. E. Canziani
      • Ileana P. Salto
      • Emanuel Barbiera Romero
      • Andrés Rocca
      • I. Doldan
      • Emmanuel Peton
      • Santiago Brayer
      • A. Sambuelli
      • S. Goncalves
      • P. Tirado
      • G. Correa
      • M. Yantorno
      • L. Garbi
      • G. Docena
      • M. Serradell
      • C. Muglia

    • PubMed: 33935778
    • DOI: 10.3389/fphar.2021.658026

    3 Insights on

    • Reduced Pro-Inflammatory Cytokines
    • Increased Regulatory T-Cells
    • Reduced Inflammatory Cytokine Secretion from Activated T Cells

    • Low evidence

  • Yeast Fermentate-Mediated Reduction of Salmonella Reading and Typhimurium in an in vitro Turkey Cecal Culture Model.

    • 2021-04-15
    • Frontiers in microbiology 12
    • • Kristina M Feye
      • Dana K Dittoe
      • Peter M Rubinelli
      • Elena G Olson
      • Steven C Ricke

    • PubMed: 33936004
    • DOI: 10.3389/fmicb.2021.645301

    1 Insight on

    • Reduced Salmonella Colonization

    • Low evidence
• April 16

  • Treatment with a Probiotic Mixture Containing Bifidobacterium animalis Subsp. Lactis BB12 and Enterococcus faecium L3 for the Prevention of Allergic Rhinitis Symptoms in Children: A Randomized Controlled Trial.

    • 2021-04-16
    • RCT · n = 250
    • Nutrients 13(4)
    • • Caterina Anania
      • Vincenza Patrizia Di Marino
      • Francesca Olivero
      • Daniela De Canditiis
      • Giulia Brindisi
      • Federico Iannilli
      • Giovanna De Castro
      • Anna Maria Zicari
      • Marzia Duse

    • PubMed: 33923532
    • DOI: 10.3390/nu13041315

    4 Insights on

    • Reduced Nasal Symptom Score
    • Reduced Oral Antihistamine Use
    • Reduced Corticosteroid Use
    • Reduced Combined Drug Use

    • High evidence
    • Large Human Trial
    • Rigorous Journal

  • Effect of Mastiha supplementation on NAFLD: The MAST4HEALTH Randomised, Controlled Trial.

    • 2021-04-16
    • RCT
    • Molecular nutrition & food research 65(10)
    • • Charalampia Amerikanou
      • Stavroula Kanoni
      • Andriana C Kaliora
      • Angela Barone
      • Mladen Bjelan
      • Giuseppe D'Auria
      • Aristea Gioxari
      • María José Gosalbes
      • Sofia Mouchti
      • Maria G Stathopoulou
      • Beatriz Soriano
      • Stefan Stojanoski
      • Rajarshi Banerjee
      • Maria Halabalaki
      • Eleni V Mikropoulou
      • Aimo Kannt
      • John Lamont
      • Carlos Llorens
      • Fernando Marascio
      • Miriam Marascio
      • Francisco J Roig
      • Ilias Smyrnioudis
      • Iraklis Varlamis
      • Sophie Visvikis-Siest
      • Milan Vukic
      • Natasa Milic
      • Milica Medic-Stojanoska
      • Lucia Cesarini
      • Jonica Campolo
      • Amalia Gastaldelli
      • Panos Deloukas
      • Maria Giovanna Trivella
      • M Pilar Francino
      • George V Dedoussis

    • PubMed: 33629536
    • DOI: 10.1002/mnfr.202001178

    7 Insights on

    • Reduced Iron-Corrected T1
    • Reduced Liver Inflammation Fibrosis Score
    • Increased Gut Microbiota Dissimilarity
    • Reduced Flavonifractor Abundance
    • Reduced Lysophosphatidylcholine Level
    • Reduced Lysophosphatidylethanolamine Level
    • Reduced Cholic Acid Level

    • High evidence
    • Rigorous Journal

  • Reduction of small dense LDL and Il-6 after intervention with Plantago psyllium in adolescents with obesity: a parallel, double blind, randomized clinical trial.

    • 2021-04-16
    • RCT · n = 113
    • European journal of pediatrics 180(8)
    • • Alma Patricia González
      • Anaisa Flores-Ramírez
      • Karla Paola Gutiérrez-Castro
      • Claudia Luévano-Contreras
      • Armando Gómez-Ojeda
      • Gloria Patricia Sosa-Bustamante
      • Russell Caccavello
      • Juan Carlos Barrera-de León
      • Ma Eugenia Garay-Sevilla
      • Alejandro Gugliucci

    • PubMed: 33861390
    • DOI: 10.1007/s00431-021-04064-5

    3 Insights on

    • Reduced Low-Density Lipoprotein Level
    • Reduced Interleukin-6 Levels
    • Increased HDL Cholesterol Levels

    • High evidence
    • Large Human Trial
• April 17

  • Lyophilized alginate-based microspheres containing Lactobacillus fermentum D12, an exopolysaccharides producer, contribute to the strain’s functionality in vitro

    • 2021-04-17
    • Microbial Cell Factories 20(1)
    • • Katarina Butorac
      • Jasna Novak
      • B. Bellich
      • Lucrecia C. Terán
      • M. Banić
      • Andreja Leboš Pavunc
      • S. Zjalić
      • P. Cescutti
      • J. Šušković
      • B. Kos

    • PubMed: 33865380
    • DOI: 10.1186/s12934-021-01575-6

    2 Insights on

    • Improved Gastrointestinal Survival
    • Improved Storage Viability

    • Low evidence
• April 19

  • Probiotics for preventing gestational diabetes.

    • 2021-04-19
    • Meta-Analysis · n = 1,647
    • The Cochrane database of systematic reviews 2021(4)
    • • Sarah J Davidson
      • Helen L Barrett
      • Sarah A Price
      • Leonie K Callaway
      • Marloes Dekker Nitert

    • PubMed: 33870484
    • DOI: 10.1002/14651858.cd009951.pub3

    2 Insights on

    • Reduced Prevalence of Gestational Diabetes Mellitus
    • Reduced Risk of Preeclampsia

    • High evidence

  • Comparative Analysis of the Microbiome across the Gut-Skin Axis in Atopic Dermatitis.

    • 2021-04-19
    • Review
    • International journal of molecular sciences 22(8)
    • • Dong Hoon Park
      • Joo Wan Kim
      • Hi-Joon Park
      • Dae-Hyun Hahm

    • PubMed: 33921772
    • DOI: 10.3390/ijms22084228

    1 Insight on

    • Improved Atopic Dermatitis Symptoms

    • Moderate evidence
    • Rigorous Journal

  • Effects of Lactobacillus plantarum CJLP55 on Clinical Improvement, Skin Condition and Urine Bacterial Extracellular Vesicles in Patients with Acne Vulgaris: A Randomized, Double-Blind, Placebo-Controlled Study

    • 2021-04-19
    • RCT · n = 14
    • Nutrients 13(4)
    • • Mi-Ju Kim
      • Kun-Pyo Kim
      • Eunhye Choi
      • J. Yim
      • Chun-Hwan Choi
      • Hyun-Sun Yun
      • H. Ahn
      • J. Oh
      • Yunhi Cho

    • PubMed: 33921829
    • DOI: 10.3390/nu13041368

    4 Insights on

    • Improved Skin Hydration
    • Reduced Sebum Triglycerides
    • Improved Epidermal Lipid Barrier Function
    • Reduced Prevalence of Proteobacteria

    • High evidence
• April 20

  • Lactobacillus Sps in Reducing the Risk of Diabetes in High-Fat Diet-Induced Diabetic Mice by Modulating the Gut Microbiome and Inhibiting Key Digestive Enzymes Associated with Diabetes

    • 2021-04-20
    • Clinical Trial
    • Biology 10(4)
    • • A. Gulnaz
      • Jawad Nadeem
      • Jong-Hun Han
      • L. Lew
      • Jae-Dong Son
      • Yong-Ha Park
      • I. Rather
      • Y. Hor

    • PubMed: 33924088
    • DOI: 10.3390/biology10040348

    3 Insights on

    • Reduced Body Weight
    • Inhibited Digestive Enzyme Activity
    • Reduced Deferribacteres in Gut Microbiota

    • Low evidence
    • Animal Study
• April 21

  • The effect of Lactiplantibacillus plantarum 299v together with a low dose of iron on iron status in healthy pregnant women: A randomized clinical trial

    • 2021-04-21
    • RCT
    • Acta Obstetricia et Gynecologica Scandinavica 100(9)
    • • U. Axling
      • G. Önning
      • Titti Martinsson Niskanen
      • N. Larsson
      • S. Hansson
      • L. Hulthén

    • PubMed: 33880752
    • DOI: 10.1111/aogs.14153

    17 Insights on

    • Improved Iron Levels
    • Improved Safety in Pregnant Women
    • Normal Pregnancy Outcomes
    • Absence of Adverse Events
    • Improved Soluble Transferrin Receptor Levels
    • Increased Total Body Iron Levels
    • Reduced Serum Ferritin Levels
    • Reduced Prevalence of Iron Deficiency
    • Reduced Iron Deficiency Anemia Prevalence
    • Enhanced Adverse Event Reporting
    • Improved Iron Storage
    • Increased Ferritin Level
    • Increased Serum Ferritin Level
    • Reduced Iron Deficiency
    • Reduced Soluble Transferrin Receptor Level
    • Increased Gestational Length
    • Increased Birthweight

    • High evidence
• April 24

  • Lactobacillus reuteri Colonisation of Extremely Preterm Infants in a Randomised Placebo-Controlled Trial

    • 2021-04-24
    • RCT · n = 132
    • Microorganisms 9(5)
    • • Johanne E Spreckels
      • Erik Wejryd
      • G. Marchini
      • B. Jonsson
      • Dylan H. de Vries
      • M. Jenmalm
      • E. Landberg
      • E. Sverremark-Ekström
      • M. Martí
      • T. Abrahamsson

    • PubMed: 33923278
    • DOI: 10.3390/microorganisms9050915

    1 Insight on

    • Improved Head Growth

    • High evidence
    • Rigorous Journal
• April 26

  • Lactobacillus plantarum KFY04 prevents obesity in mice through the PPAR pathway and alleviates oxidative damage and inflammation.

    • 2021-04-26
    • Clinical Trial
    • Food & Function 11(6)
    • • X. Long
      • Xiaofei Zeng
      • Fang Tan
      • Ruokun Yi
      • Yanni Pan
      • Xianrong Zhou
      • Jianfei Mu
      • Xin Zhao

    • PubMed: 32490861
    • DOI: 10.1039/d0fo00519c

    8 Insights on

    • Reduced Inflammation Levels
    • Improved Lipid Profile
    • Reduced Inflammation
    • Reduced Weight Gain
    • Reduced Oxidative Damage
    • Reduced Liver Fat Formation
    • Slower Weight Gain
    • Reduced Liver Fat Vacuoles

    • Low evidence
    • Animal Study

  • Lactobacillus casei LH23 modulates the immune response and ameliorates DSS-induced colitis via suppressing JNK/p-38 signal pathways and enhancing histone H3K9 acetylation.

    • 2021-04-26
    • Clinical Trial
    • Food & Function 11(6)
    • • Mei-ling Liu
      • Jinhua Ding
      • Hongmin Zhang
      • Jing Shen
      • Y. Hao
      • Xiuxia Zhang
      • W. Qi
      • Xuegang Luo
      • Tongcun Zhang
      • Nan Wang

    • PubMed: 32495801
    • DOI: 10.1039/d0fo00546k

    7 Insights on

    • Increased Short-Chain Fatty Acid Levels
    • Increased Regulatory T-Cells
    • Reduced Colitis Symptoms
    • Reduced Inflammation Levels
    • Reduced Myeloperoxidase Levels
    • Increased Regulatory T Cell Count
    • Reduced Myeloperoxidase Activity

    • Low evidence
    • Animal Study

  • Oral administration of Lactobacillus fermentum post-weaning improves the lipid profile and autonomic dysfunction in rat offspring exposed to maternal dyslipidemia.

    • 2021-04-26
    • RCT · n = 14
    • Food & Function 11(6)
    • • Y. de Oliveira
      • R. G. S. Cavalcante
      • M. P. Cavalcanti Neto
      • M. Magnani
      • V. Braga
      • E. L. de Souza
      • J. L. de Brito Alves

    • PubMed: 32524104
    • DOI: 10.1039/d0fo00514b

    5 Insights on

    • Reduced Blood Pressure
    • Improved Lipid Profile
    • Improved Fecal Lactobacillus Count
    • Improved Blood Pressure
    • Improved Sympathetic Tone

    • Low evidence
    • Animal Study
• April 27

  • Fermentation for future food systems: Precision fermentation can complement the scope and applications of traditional fermentation.

    • 2021-04-27
    • EMBO reports 22(5)
    • • Ting Shien Teng
      • Yi Ling Chin
      • Kong Fei Chai
      • Wei Ning Chen

    • PubMed: 33908143
    • DOI: 10.15252/embr.202152680

    3 Insights on

    • Improved Skin Hydration
    • Improved Skin Elasticity
    • Reduced Skin Oiliness

    • Low evidence

  • The effect of brown rice compared to white rice on adiposity indices, lipid profile, and glycemic markers: a systematic review and meta-analysis of randomized controlled trials.

    • 2021-04-27
    • Meta-Analysis · n = 6
    • Critical reviews in food science and nutrition 62(27)
    • • Mahdieh Golzarand
      • Karamollah Toolabi
      • Sina Eskandari Delfan
      • Parvin Mirmiran

    • PubMed: 33905269
    • DOI: 10.1080/10408398.2021.1914541

    3 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Body Weight

    • High evidence
• April 29

  • Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis.

    • 2021-04-29
    • Meta-Analysis
    • Nutrition reviews 80(3)
    • • Yanjun Wu
      • Liming Zhang
      • Suyun Li
      • Dongfeng Zhang

    • PubMed: 33912967
    • DOI: 10.1093/nutrit/nuab014

    1 Insight on

    • Reduced Depression Risk

    • High evidence

  • Early supplementation with Lactobacillus plantarum in liquid diet modulates intestinal innate immunity through TLR4-mediated mitogen-activated protein kinase signaling pathways in young piglets challenged with Escherichia coli K88.

    • 2021-04-29
    • Journal of Animal Science 99(6)
    • • Kuanmin Yang
      • Cui Zhu
      • Li Wang
      • S. Cao
      • Xuefen Yang
      • K. Gao
      • Zong-yong Jiang

    • PubMed: 33928383
    • DOI: 10.1093/jas/skab128

    3 Insights on

    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Intestinal Immune Cell Count
    • Reduced Inflammatory Marker Protein Levels

    • Low evidence
    • Rigorous Journal
• April 30

  • Prolonged Treatment with Grains of Paradise (Aframomum melegueta) Extract Recruits Adaptive Thermogenesis and Reduces Body Fat in Humans with Low Brown Fat Activity.

    • 2021-04-30
    • RCT
    • Journal of nutritional science and vitaminology 67(2)
    • • Takeshi Yoneshiro
      • Mami Matsushita
      • Jun Sugita
      • Sayuri Aita
      • Toshimitsu Kameya
      • Hiroki Sugie
      • Masayuki Saito

    • PubMed: 33952741
    • DOI: 10.3177/jnsv.67.99

    1 Insight on

    • Reduced Body Fat Percentage

    • High evidence
• Undated – 4 supplement studies

  • Gut fermentation syndrome: A systematic review of case reports.

    • 2021-04
    • Systematic Review · n = 20
    • United European gastroenterology journal 9(3)
    • • Ahmed B Bayoumy
      • Chris J J Mulder
      • Jaap J Mol
      • Maarten E Tushuizen

    • PubMed: 33887125
    • DOI: 10.1002/ueg2.12062

    1 Insight on

    • Reduced Gastrointestinal Microbial Fermentation-Related Intoxication

    • High evidence

  • The effect of probiotic fermented milk products on blood lipid concentrations: A systematic review and meta-analysis of randomized controlled trials.

    • 2021-04
    • Meta-Analysis
    • Nutrition, Metabolism and Cardiovascular Diseases 31(4)
    • • Rahele Ziaei
      • A. Ghavami
      • S. Khalesi
      • R. Ghiasvand
      • Amin Mokari Yamchi

    • PubMed: 33612379
    • DOI: 10.1016/j.numecd.2020.12.023

    2 Insights on

    • Reduced Total Cholesterol Levels
    • Reduced LDL Cholesterol

    • High evidence

  • Bifidobacterium longum W11: Uniqueness and individual or combined clinical use in association with rifaximin.

    • 2021-04
    • Systematic Review
    • Clinical Nutrition ESPEN 42
    • • F. Di Pierro
      • M. Pane

    • PubMed: 33745570
    • DOI: 10.1016/j.clnesp.2020.12.025

    6 Insights on

    • Reduced IBS Symptoms
    • Alleviated Constipation
    • Improved Minimal Hepatic Encephalopathy
    • Improved Symptomatic Uncomplicated Diverticular Disease
    • Improved Hepatic Disease
    • Reduced Constipation Symptoms in IBS

    • High evidence

  • Bacillus coagulans R11 consumption influenced the abundances of cecum antibiotic resistance genes in lead-exposed laying hens.

    • 2021-04
    • Environmental Pollution 274
    • • Sicheng Xing
      • Jing-Yuan Chen
      • Yingfeng Cai
      • Chunbo Huang
      • Xin-Di Liao
      • J. Mi

    • PubMed: 33545525
    • DOI: 10.1016/j.envpol.2021.116562

    4 Insights on

    • Reduced ARG Abundance in the Absence of Lead
    • Increased Abundance of Antibiotic Resistance Genes
    • Increased ARG Abundances Due to Lead Exposure
    • Reduced ARG Abundance Without Lead Exposure

    • Low evidence