May 2021 Supplement Research Papers

• May 1

  • Evaluation of graded levels of Bacillus coagulans GBI-30, 6086 on apparent nutrient digestibility, stool quality, and intestinal health indicators in healthy adult dogs

    • 2021-05-01
    • RCT · n = 10
    • Journal of Animal Science 99(5)
    • • Heather L Acuff
      • C. Aldrich

    • PubMed: 33940614
    • DOI: 10.1093/jas/skab137

    2 Insights on

    • Improved Nutrient Digestibility
    • Improved Stool Quality

    • Low evidence
    • Rigorous Journal
    • Animal Study
• May 4

  • The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics.

    • 2021-05-04
    • Review
    • Nature reviews. Gastroenterology & hepatology 18(9)
    • • Seppo Salminen
      • Maria Carmen Collado
      • Akihito Endo
      • Colin Hill
      • Sarah Lebeer
      • Eamonn M M Quigley
      • Mary Ellen Sanders
      • Raanan Shamir
      • Jonathan R Swann
      • Hania Szajewska
      • Gabriel Vinderola

    • PubMed: 33948025
    • DOI: 10.1038/s41575-021-00440-6

    6 Insights on

    • Improved Skin Hydration
    • Improved Sleep Quality
    • Reduced Parental Absenteeism from Work
    • Reduced Upper Respiratory Tract Infection Symptoms
    • Reduced Cold/Flu Severity
    • Reduced Skin Sensitivity

    • Moderate evidence
    • Highly Cited
• May 5

  • Probiotic and Oxytocin Combination Therapy in Patients with Autism Spectrum Disorder: A Randomized, Double-Blinded, Placebo-Controlled Pilot Trial

    • 2021-05-05
    • RCT · n = 35
    • Nutrients 13(5)
    • • Xue-Jun Kong
      • Jun Liu
      • Kevin Liu
      • Madelyn Koh
      • H. Sherman
      • Siyu Liu
      • Ruiyi Tian
      • Piyawat Sukijthamapan
      • Jiuju Wang
      • Michelle Fong
      • Lei Xu
      • Cullen Clairmont
      • Min-Seo Jeong
      • A. Li
      • M. Lopes
      • Veronica Hagan
      • Tess Dutton
      • S-T. Chan
      • Hang Lee
      • A. Kendall
      • K. Kwong
      • Yiqing Song

    • PubMed: 34062986
    • DOI: 10.3390/nu13051552

    1 Insight on

    • Improved Social Emotional Cognition

    • High evidence
• May 6

  • Lactobacillus sakei Pro-Bio65 Reduces TNF-α Expression and Upregulates GSH Content and Antioxidant Enzymatic Activities in Human Conjunctival Cells

    • 2021-05-06
    • Translational Vision Science & Technology 10(6)
    • • R. Iorio
      • S. Petricca
      • Carla Luzi
      • P. Bellio
      • L. Cristiano
      • C. Festuccia
      • G. Amicosante
      • G. Celenza

    • PubMed: 34111255
    • DOI: 10.1167/tvst.10.6.8

    3 Insights on

    • Reduced TNF-α Levels
    • Increased Glutathione Levels
    • Improved Antioxidant Defense

    • Low evidence
    • Rigorous Journal
• May 7

  • Streptococcus salivarius inhibits immune activation by periodontal disease pathogens

    • 2021-05-07
    • BMC Oral Health 21(1)
    • • K. Macdonald
      • R. Chanyi
      • Jean M. Macklaim
      • P. Cadieux
      • G. Reid
      • J. Burton

    • PubMed: 33962608
    • DOI: 10.1186/s12903-021-01606-z

    3 Insights on

    • Reduced Inflammatory Response
    • Reduced Pro-inflammatory Cytokine Levels
    • Unchanged Salivary Microbiome

    • Moderate evidence

  • Efficacy and safety of biophenol-rich nutraceuticals in adults with inflammatory gastrointestinal diseases or irritable bowel syndrome: A systematic literature review and meta-analysis.

    • 2021-05-07
    • Meta-Analysis
    • Nutrition & dietetics : the journal of the Dietitians Association of Australia 79(1)
    • • Joanna Giang
      • Xiao Lan
      • Megan Crichton
      • Wolfgang Marx
      • Skye Marshall

    • PubMed: 33960587
    • DOI: 10.1111/1747-0080.12672

    2 Insights on

    • Improved Quality of Life
    • Improved Gastrointestinal Symptoms

    • High evidence
• May 10

  • Effect of Lacticaseibacillus paracasei Strain Shirota on Improvement in Depressive Symptoms, and Its Association with Abundance of Actinobacteria in Gut Microbiota

    • 2021-05-10
    • Microorganisms 9(5)
    • • Machiko Otaka
      • H. Kikuchi-Hayakawa
      • Junpei Ogura
      • H. Ishikawa
      • Y. Yomogida
      • M. Ota
      • S. Hidese
      • Ikki Ishida
      • M. Aida
      • K. Matsuda
      • M. Kawai
      • S. Yoshida
      • H. Kunugi

    • PubMed: 34068832
    • DOI: 10.3390/microorganisms9051026

    1 Insight on

    • Reduced Depression Symptoms

    • Low evidence
    • Rigorous Journal

  • Probiotic Lactobacillus kefiri prevents endotoxin-induced preterm birth and stillbirth in mice.

    • 2021-05-10
    • Reproduction (Cambridge, England) 161(6)
    • • María Silvia Ventimiglia
      • Natalin Jimena Valeff
      • Marlon Pozo Albán
      • Juan Manuel Paturlanne
      • Lorena Juriol
      • Florencia Quadrana
      • Martina Cecotti
      • Mariano Malamud
      • Marcos Javier Dibo
      • María de Los Ángeles Serradell
      • Federico Jensen

    • PubMed: 33835045
    • DOI: 10.1530/rep-20-0642

    5 Insights on

    • Reduced Preterm Births
    • Reduced Inflammation in the Female Reproductive Tract
    • Reduced Stillbirth
    • Improved Postnatal Development
    • Modulated Vaginal Microbiota Diversity

    • Low evidence
    • Animal Study

  • Probiotics: To Use or Not to Use? That Is the Question.

    • 2021-05-10
    • Systematic Review
    • American Journal of Gastroenterology 116(7)
    • • M. Schmulson

    • PubMed: 33973898
    • DOI: 10.14309/ajg.0000000000001299

    1 Insight on

    • No Change in Gastroenteritis Symptoms

    • High evidence
• May 11

  • Administration of Bifidobacterium breve Improves the Brain Function of Aβ1-42-Treated Mice via the Modulation of the Gut Microbiome

    • 2021-05-11
    • Clinical Trial
    • Nutrients 13(5)
    • • G. Zhu
      • Jianxin Zhao
      • Hao Zhang
      • Wei Chen
      • Gang Wang

    • PubMed: 34064762
    • DOI: 10.3390/nu13051602

    11 Insights on

    • Improved Cognitive Function
    • Improved Gut Microbiome
    • Increased Serum BDNF Levels
    • Enhanced Brain-Derived Neurotrophic Factor Levels
    • Improved Behavioral Abnormalities
    • Improved Synaptic Plasticity
    • Increased FNDC5 Concentration
    • Increased PSD-95 Concentration
    • Increased Fibronectin Type III Domain-Containing Protein 5 Levels
    • Increased Postsynaptic Density Protein 95 Levels
    • Reduced Alzheimer's Disease-Associated Gut Dysbiosis

    • Low evidence
    • Animal Study

  • Dried Plum Consumption Improves Total Cholesterol and Antioxidant Capacity and Reduces Inflammation in Healthy Postmenopausal Women.

    • 2021-05-11
    • RCT
    • Journal of medicinal food 24(11)
    • • Mee Young Hong
      • Mark Kern
      • Michelle Nakamichi-Lee
      • Nazanin Abbaspour
      • Arshya Ahouraei Far
      • Shirin Hooshmand

    • PubMed: 33978491
    • DOI: 10.1089/jmf.2020.0142

    9 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Interleukin-6 Levels
    • Increased Antioxidant Enzyme Levels
    • Reduced Total Cholesterol
    • Increased Total Serum Antioxidant Capacity
    • Increased High-Density Lipoprotein Cholesterol
    • Reduced Alanine Transaminase Level
    • Reduced Lactate Dehydrogenase Level
    • Reduced Creatine Kinase Level

    • High evidence
• May 12

  • Supplementation of Lactobacillus early in life alters attention bias to threat in piglets

    • 2021-05-12
    • RCT · n = 64
    • Scientific Reports 11(1)
    • • E. Verbeek
      • J. Dicksved
      • L. Keeling

    • PubMed: 33980959
    • DOI: 10.1038/s41598-021-89560-2

    2 Insights on

    • Reduced Vigilance Behavior
    • Enhanced Threat Response Appropriateness

    • Low evidence
    • Rigorous Journal
    • Animal Study
• May 14

  • Lactiplantibacillus plantarum WJL administration during pregnancy and lactation improves lipid profile, insulin sensitivity and gut microbiota diversity in dyslipidemic dams and protects male offspring against cardiovascular dysfunction in later life.

    • 2021-05-14
    • RCT · n = 15
    • Food & Function 11(10)
    • • K. Guimarães
      • V. Braga
      • S. Noronha
      • Whyara K A Costa
      • Kassem Makki
      • J. Cruz
      • Larissa Ramalho Brandão
      • Deoclecio Alves Chianca Junior
      • E. Meugnier
      • F. Leulier
      • H. Vidal
      • M. Magnani
      • J. L. de Brito Alves

    • PubMed: 33000822
    • DOI: 10.1039/d0fo01718c

    8 Insights on

    • Improved Insulin Sensitivity
    • Improved Gut Microbiota Diversity
    • Reduced Blood Pressure
    • Improved Lipid Profile
    • Reduced Blood Pressure in Offspring
    • Improved Vascular Function in Offspring
    • Improved Vascular Function
    • Reduced Cardiovascular Dysfunction

    • Low evidence
    • Animal Study

  • Antioxidant and Anti-Inflammatory Properties of Probiotic Candidate Strains Isolated during Fermentation of Agave (Agave angustifolia Haw).

    • 2021-05-14
    • Microorganisms 9(5)
    • • Natalia C Hernández-Delgado
      • Edgar Torres-Maravilla
      • Lino Mayorga-Reyes
      • Rebeca Martín
      • Philippe Langella
      • Ricardo Pérez-Pastén-Borja
      • María E Sánchez-Pardo
      • Luis G Bermúdez-Humarán

    • PubMed: 34069080
    • DOI: 10.3390/microorganisms9051063

    2 Insights on

    • Reduced Intestinal Permeability
    • Reduced Weight Loss

    • Low evidence
• May 15

  • Effect of Lactobacillus helveticus CD6 on serum lipid profile and indicators of liver function in high-fat diet fed Swiss albino mice

    • 2021-05-15
    • RCT · n = 24
    • 3 Biotech 11(6)
    • • Mahesh P. Patil
      • J. Ahire
      • Ulhas Patil
      • B. Bhushan
      • B. Chaudhari

    • PubMed: 34017672
    • DOI: 10.1007/s13205-021-02832-6

    4 Insights on

    • Improved Liver Function
    • Improved Lipid Profile
    • Reduced Weight Gain
    • Maintained Normal Liver Function

    • Low evidence
    • Animal Study
• May 17

  • Lactobacillus rhamnosus LRa05 improves lipid accumulation in mice fed with a high fat diet via regulating the intestinal microbiota, reducing glucose content and promoting liver carbohydrate metabolism.

    • 2021-05-17
    • Clinical Trial
    • Food & Function 11(11)
    • • Mengzhen Sun
      • Tao Wu
      • Guohua Zhang
      • Rui Liu
      • Wenjie Sui
      • Maomao Zhang
      • Jieting Geng
      • Jinjin Yin
      • M. Zhang

    • PubMed: 33063800
    • DOI: 10.1039/d0fo01720e

    13 Insights on

    • Reduced Body Weight
    • Improved Carbohydrate Metabolism
    • Reduced Liver Lipid Accumulation
    • Improved Lipid Profile
    • Reduced Blood Glucose Levels
    • Improved Gut Microbiome Composition
    • Reduced Weight Gain
    • Improved Lipid Levels
    • Reduced Lipid Levels
    • Balanced Gut Microbiota
    • Reduced Hepatic Lipid Accumulation
    • Reduced Abundance of Pro-Pathogenic Bacteria
    • Reduced Epididymal Fat Tissue Accumulation

    • Low evidence
    • Animal Study
• May 18

  • Lactobacillus fermentum KP-3-fermented ginseng ameliorates alcohol-induced liver disease in C57BL/6N mice through the AMPK and MAPK pathways.

    • 2021-05-18
    • RCT · n = 4
    • Food & Function 11(11)
    • • Ying You
      • Yanlong Liu
      • Zhiyi Ai
      • Yushan Wang
      • Junmei Liu
      • Chunhong Piao
      • Yuhua Wang

    • PubMed: 33079125
    • DOI: 10.1039/D0FO02396E

    7 Insights on

    • Reduced Total Cholesterol Levels
    • Reduced Aminotransferase Levels
    • Reduced Triglyceride Levels
    • Reduced Plasma Lipopolysaccharide Levels
    • Reduced AST Levels
    • Reduced Inflammation
    • Reduced Liver Oxidative Damage

    • Low evidence
    • Animal Study

  • Beta-Alanine Supplementation and Sport Climbing Performance.

    • 2021-05-18
    • RCT
    • International journal of environmental research and public health 18(10)
    • • Krzysztof Sas-Nowosielski
      • Judyta Wyciślik
      • Piotr Kaczka

    • PubMed: 34069981
    • DOI: 10.3390/ijerph18105370

    6 Insights on

    • Increased Stool Frequency
    • Increased SLAP Lesion Count
    • Increased Time to Failure
    • Increased Number of Moves
    • Improved Campus Board Performance
    • Improved Bouldering Traverse Performance

    • High evidence

  • Sex-dependent changes in the microbiota profile, serum metabolism, and hormone levels of growing pigs after dietary supplementation with Lactobacillus

    • 2021-05-18
    • Clinical Trial
    • Applied Microbiology and Biotechnology 105(11)
    • • Dongyan Zhang
      • Hui Liu
      • Sixin Wang
      • Wei Zhang
      • Shuaiqin Wang
      • Yamin Wang
      • H. Ji

    • PubMed: 34003306
    • DOI: 10.1007/s00253-021-11310-1

    8 Insights on

    • Improved Lipid Metabolism
    • Improved Microbial Diversity
    • Increased Serum Serotonin Levels
    • Altered Microbial Phyla Abundance
    • Increased Serum Insulin Levels
    • Increased Serum Total Bile Acid Levels
    • Elevated Serum Lipoprotein Lipase Levels in Gilts
    • Increased Serum NAD+ Levels

    • Low evidence
    • Animal Study

  • Heat-killed Lactobacillus plantarum L-137 attenuates obesity and associated metabolic abnormalities in C57BL/6 J mice on a high-fat diet

    • 2021-05-18
    • Clinical Trial
    • Bioscience of Microbiota, Food and Health 40(2)
    • • Rieko Yoshitake
      • Y. Hirose
      • S. Murosaki
      • G. Matsuzaki

    • PubMed: 33996364
    • DOI: 10.12938/bmfh.2020-040

    10 Insights on

    • Reduced Aminotransferase Levels
    • Reduced Endotoxin Levels
    • Improved Lipid Metabolism
    • Reduced Liver Enzyme Levels
    • Reduced Aspartate Transaminase Activity
    • Reduced Weight Gain
    • Reduced Metabolic Endotoxemia
    • Lower Plasma Glucose Levels
    • Reduced Inflammation in Adipose Tissue
    • Improved Glycemia

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • The Effect of Lactococcus lactis subsp. lactis PTCC 1403 on the Growth Performance, Digestive Enzymes Activity, Antioxidative Status, Immune Response, and Disease Resistance of Rainbow Trout (Oncorhynchus mykiss)

    • 2021-05-18
    • Probiotics and Antimicrobial Proteins 13(6)
    • • Sakineh Yeganeh
      • Milad Adel
      • Ahmad Nosratimovafagh
      • Mahmoud A. O. Dawood

    • PubMed: 34002350
    • DOI: 10.1007/s12602-021-09787-3

    13 Insights on

    • Increased Serum Lysozyme Activity
    • Improved Immune Response
    • Enhanced Disease Resistance
    • Reduced Serum Glucose Levels
    • Improved Cell Survival Rates
    • Enhanced Digestive Enzyme Activity
    • Reduced Blood Glucose Levels
    • Enhanced Antioxidant Response
    • Lower Plasma Glucose Levels
    • Reduced Mortality Risk
    • Enhanced Protein Efficiency Ratio
    • Increased Immunoglobulin M
    • Improved Antioxidative Response

    • Low evidence
• May 21

  • Health-Promoting Properties of Lactobacilli in Fermented Dairy Products.

    • 2021-05-21
    • Review
    • Frontiers in microbiology 12
    • • Yantyati Widyastuti
      • Andi Febrisiantosa
      • Flavio Tidona

    • PubMed: 34093496
    • DOI: 10.3389/fmicb.2021.673890

    3 Insights on

    • Improved Gut Microbiota Balance
    • Improved Human Health
    • Improved Host Health

    • Low evidence
• May 22

  • Influence of the Phenological Stage and Harvest Date on the Bioactive Compounds Content of Green Pepper Fruit

    • 2021-05-22
    • Molecules 26(11)
    • • Alicia Dobón-Suárez
      • M. J. Giménez
      • S. Castillo
      • M. García-Pastor
      • P. Zapata

    • PubMed: 34067307
    • DOI: 10.3390/molecules26113099

    1 Insight on

    • Increased Antioxidant Activity

    • Low evidence
• May 27

  • Kefir and Its Biological Activities

    • 2021-05-27
    • Review
    • Foods 10(6)
    • • Nor Farahin Azizi
      • M. R. Kumar
      • S. Yeap
      • J. Abdullah
      • Melati Khalid
      • A. Omar
      • M. Osman
      • S. S. Mortadza
      • N. Alitheen

    • PubMed: 34071977
    • DOI: 10.3390/foods10061210

    16 Insights on

    • Improved Gastrointestinal Health
    • Reduced Blood Pressure
    • Increased Antioxidant Activity
    • Reduced Inflammation Levels
    • Reduced Serum Cholesterol Levels
    • Reduced Cancer Risk
    • Reduced Hypertension
    • Improved Anti-Oxidative Effects
    • Reduced Microbial Load
    • Reduced Blood Glucose Levels
    • Improved Overall Health
    • Reduced Inflammation
    • Improved Glycemia
    • Multiple Health-Promoting Effects
    • Improved Functional Beverage Potential
    • Increased Interest in Nutritional Potential

    • Moderate evidence
    • Rigorous Journal

  • Identification of the key characteristics of Bifidobacterium longum strains for the alleviation of ulcerative colitis.

    • 2021-05-27
    • Clinical Trial
    • Food & Function 12(8)
    • • Chengcheng Zhang
      • Yan Zhao
      • Jinchi Jiang
      • Leilei Yu
      • F. Tian
      • Jianxin Zhao
      • Hao Zhang
      • Wei Chen
      • Q. Zhai

    • PubMed: 33900330
    • DOI: 10.1039/d1fo00017a

    3 Insights on

    • Reduced Inflammation Levels
    • Recovered Colon Length
    • Maintained Mucosal Barrier Integrity

    • Low evidence
    • Animal Study
• May 28

  • The ameliorative effect of Lactobacillus plantarum-12 on DSS-induced murine colitis.

    • 2021-05-28
    • Clinical Trial
    • Food & Function 11(6)
    • • Mengying Sun
      • Yujun Liu
      • Yinglong Song
      • Yuan Gao
      • Fujunzhu Zhao
      • Yanghe Luo
      • Fang Qian
      • Guangqing Mu
      • Y. Tuo

    • PubMed: 32458908
    • DOI: 10.1039/d0fo00007h

    16 Insights on

    • Improved Intestinal Barrier Function
    • Improved Immune Function
    • Improved Immune Response
    • Reduced Ulcerative Colitis Symptoms
    • Reduced Colitis Symptoms
    • Reduced Colonic Inflammation
    • Reduced Intestinal Inflammation
    • Improved Gut Microbiota Balance
    • Improved Gut Microbiome Composition
    • Restored Normal Microbiota
    • Improved Immunity
    • Enhanced Intestinal Barrier Function
    • Improved Ulcerative Colitis
    • Reduced Colonic Atrophy
    • Improved Intestinal Histopathology
    • Improved Immune System Function via JAK-STAT Pathway Activation

    • Low evidence
    • Animal Study

  • Lactobacillus fermentum CECT5716 prevents renal damage in the NZBWF1 mouse model of systemic lupus erythematosus.

    • 2021-05-28
    • RCT
    • Food & Function 11(6)
    • • Néstor de la Visitación
      • Iñaki Robles‐Vera
      • M. Toral
      • F. O’Valle
      • Javier Moleón
      • M. Gómez-Guzmán
      • M. Romero
      • Marcos Duarte
      • Manuel Calderón Sánchez
      • R. Jiménez
      • J. Duarte

    • PubMed: 32458936
    • DOI: 10.1039/d0fo00578a

    11 Insights on

    • Reduced Blood Pressure
    • Reduced Endotoxin Levels
    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Hypertension
    • Reduced Plasma Anti-dsDNA Levels
    • Improved Kidney Function
    • Reduced Kidney Damage
    • Reduced Kidney Injury
    • Reduced Kidney Histological Damage
    • Reduced NADPH Oxidase Activity
    • Reduced Lupus-Associated Renal Damage

    • Low evidence
    • Animal Study

  • The Effect of Continuous Intake of Lactobacillus gasseri OLL2716 on Mild to Moderate Delayed Gastric Emptying: A Randomized Controlled Study

    • 2021-05-28
    • RCT · n = 28
    • Nutrients 13(6)
    • • Toshihiro Ohtsu
      • K. Haruma
      • Yumiko Ide
      • A. Takagi

    • PubMed: 34071718
    • DOI: 10.3390/nu13061852

    2 Insights on

    • Enhanced Autonomic Function
    • Improved Gastric Emptying Time

    • High evidence
• May 30

  • Inhibition of Quinolone- and Multi-Drug-Resistant Clostridioides Difficile Strains by Multi Strain Synbiotics-An Option for Diarrhea Management in Nursing Facilities.

    • 2021-05-30
    • Observational
    • International journal of environmental research and public health 18(11)
    • • Henning Sommermeyer
      • Hanna M Pituch
      • Dorota Wultanska
      • Paulina Wojtyla-Buciora
      • Jacek Piatek
      • Malgorzata Bernatek

    • PubMed: 34070727
    • DOI: 10.3390/ijerph18115871

    1 Insight on

    • Reduced Clostridium Difficile Growth

    • Low evidence

  • Effects of Bifidobacterium animalis ssp. lactis 420 on gastrointestinal inflammation induced by a nonsteroidal anti‐inflammatory drug: A randomized, placebo‐controlled, double‐blind clinical trial

    • 2021-05-30
    • RCT
    • British Journal of Clinical Pharmacology 87(12)
    • • S. Mäkelä
      • S. Forssten
      • M. Kailajärvi
      • V. Langén
      • M. Scheinin
      • K. Tiihonen
      • A. Ouwehand

    • PubMed: 33908058
    • DOI: 10.1111/bcp.14880

    1 Insight on

    • Reduced Gastrointestinal Inflammation

    • Low evidence
    • Animal Study
• May 31

  • Dietary Lactobacillus fermentum and Bacillus coagulans Supplementation Modulates Intestinal Immunity and Microbiota of Broiler Chickens Challenged by Clostridium perfringens

    • 2021-05-31
    • RCT
    • Frontiers in Veterinary Science 8
    • • Shuangshuang Guo
      • Y. Xi
      • Yi Xia
      • Tao Wu
      • Di Zhao
      • Z. Zhang
      • B. Ding

    • PubMed: 34136557
    • DOI: 10.3389/fvets.2021.680742

    25 Insights on

    • Improved Immune Response
    • Reduced Intestinal Inflammation
    • Improved Gut Health
    • Increased Microbial Richness in the Large Intestine
    • Improved Gut Microbiota Richness
    • Enhanced Intestinal Immunity
    • Improved Gut Microbiome Composition
    • Modulated Immune Response
    • Enhanced Beneficial Microbial Populations
    • Improved Amino Acid Metabolism
    • Improved Microbial Diversity
    • Increased T Cell Count
    • Improved Gut Microbial Richness
    • Regulated Gut Microbiota Metabolic Function
    • Altered Microbial Composition
    • Improved Intestinal Immune Response
    • Improved Microbial Metabolism Regulation
    • Stabilized Amino Acid Metabolism
    • Enhanced Jejunal Immune Response
    • Improved Jejunal T-Cell Count
    • Increased Immune Cell Presence
    • Regulated Microbial Metabolism
    • Enhanced T-Cell Response
    • Regulated Metabolic Function
    • Regulated Microbiota Function

    • High evidence

  • Alleviation of LPS-Induced Inflammation and Septic Shock by Lactiplantibacillus plantarum K8 Lysates

    • 2021-05-31
    • Clinical Trial
    • International Journal of Molecular Sciences 22(11)
    • • Gayoung Kim
      • K. Choi
      • Hangeun Kim
      • D. Chung

    • PubMed: 34072918
    • DOI: 10.3390/ijms22115921

    3 Insights on

    • Reduced Liver Inflammation
    • Reduced Inflammation Levels
    • Reduced Mortality from Endotoxin Shock

    • Low evidence
    • Animal Study
• Undated – 7 supplement studies

  • Lactobacillus fermentum CECT5716 ameliorates high fat diet-induced obesity in mice through modulation of gut microbiota dysbiosis.

    • 2021-05
    • Pharmacological research 167
    • • Jose Alberto Molina-Tijeras
      • Patricia Diez-Echave
      • Teresa Vezza
      • Laura Hidalgo-García
      • Antonio Jesús Ruiz-Malagón
      • Maria Jesús Rodríguez-Sojo
      • Miguel Romero
      • Iñaki Robles-Vera
      • Federico García
      • Julio Plaza-Diaz
      • Mónica Olivares
      • Juan Duarte
      • Maria Elena Rodríguez-Cabezas
      • Alba Rodríguez-Nogales
      • Julio Gálvez

    • PubMed: 33529749
    • DOI: 10.1016/j.phrs.2021.105471

    4 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Body Weight
    • Reduced Inflammation
    • Improved Vascular Endothelial Function

    • Low evidence
    • Animal Study

  • Evaluation of fermentation assisted by Lactobacillus brevis POM, and Lactobacillus plantarum (TR-7, TR-71, TR-14) on antioxidant compounds and organic acids of an orange juice-milk based beverage.

    • 2021-05
    • Food Chemistry 343
    • • B. de la Fuente
      • C. Luz
      • C. Puchol
      • G. Meca
      • F. Barba

    • PubMed: 33131951
    • DOI: 10.1016/j.foodchem.2020.128414

    4 Insights on

    • Improved Antioxidant Capacity
    • Enhanced Polyphenol Levels
    • Enhanced Carotenoid Levels
    • Increased Organic Acid Levels

    • Low evidence

  • Bacillus amyloliquefaciens B10 can alleviate liver apoptosis and oxidative stress induced by aflatoxin B1.

    • 2021-05
    • RCT · n = 4
    • Food and Chemical Toxicology 151
    • • Xiaotong Li
      • Z. Lv
      • Jia Chen
      • E. Nepovimova
      • M. Long
      • Wenda Wu
      • K. Kuča

    • PubMed: 33727180
    • DOI: 10.1016/j.fct.2021.112124

    2 Insights on

    • Reduced Oxidative Stress
    • Reduced Hepatic Apoptosis

    • Low evidence
    • Animal Study

  • Saccharomyces cerevisiae fungemia: Risk factors, outcome and links with S. boulardii-containing probiotic administration.

    • 2021-05
    • Infectious Diseases Now 51(3)
    • • A. Poncelet
      • L. Ruelle
      • D. Konopnicki
      • V. Y. Miendje Deyi
      • N. Dauby

    • PubMed: 33934809
    • DOI: 10.1016/j.idnow.2020.12.003

    4 Insights on

    • Saccharomyces Cerevisiae Fungemia
    • Increased Mortality Rate
    • Increased Mortality
    • Increased Infection

    • Low evidence

  • Lactobacillus plantarum GB LP-1 as a direct-fed microbial for neonatal calves.

    • 2021-05
    • RCT
    • Journal of Dairy Science 104(5)
    • • D. Casper
      • K. Hultquist
      • I. Acharya

    • PubMed: 33663862
    • DOI: 10.3168/jds.2020-19438

    4 Insights on

    • Increased Body Weight
    • Improved Average Daily Gain
    • Improved Growth Performance
    • Improved Gut Health

    • High evidence
    • Rigorous Journal

  • Use of a probiotic mixture containing Bifidobacterium animalis subsp. lactis BB-12 and Enterococcus faecium L3 as prophylaxis to reduce the incidence of acute gastroenteritis and upper respiratory tract infections in children.

    • 2021-05
    • RCT
    • Minerva pediatrics 73(3)
    • • Francesco DI Pierro
      • Patrizia Lo Russo
      • Maria L Danza
      • Isabella Basile
      • Stefania Soardo
      • Giovanni Capocasale
      • Sandro B Paparone
      • Vittoria Paletta
      • Cosimo Lanza
      • Elvira Schiavone
      • Paolo Risso
      • Maria Colombo

    • PubMed: 32506882
    • DOI: 10.23736/s2724-5276.20.05925-3

    7 Insights on

    • Reduced Incidence of Upper Respiratory Tract Infections
    • Increased Salivary sIgA Levels
    • Reduced Duration of Upper Respiratory Tract Infection
    • Reduced Incidence of Gastroenteritis
    • Reduced Duration of Acute Gastroenteritis
    • Reduced Upper Respiratory Tract Infection
    • Reduced Upper Respiratory Tract Infection Duration

    • High evidence

  • Fermented milk with Lactobacillus curvatus SMFM2016-NK alleviates periodontal and gut inflammation, and alters oral and gut microbiota.

    • 2021-05
    • Journal of Dairy Science 104(5)
    • • Y. Choi
      • E. Park
      • S. Kim
      • J. Ha
      • H. Oh
      • Y. Kim
      • Y. Lee
      • Y. Seo
      • J. Kang
      • S. Lee
      • H. Lee
      • Y. Yoon
      • K.-H. Choi

    • PubMed: 33685682
    • DOI: 10.3168/jds.2020-19625

    3 Insights on

    • Reduced Periodontal Inflammation
    • Improved Gut Inflammation
    • Altered Oral Microbiota

    • Low evidence
    • Rigorous Journal