February 2024 Supplement Research Papers

• February 1

  • Outcomes of Serum Food-Specific Immunoglobulin G 4 to Guide Elimination Diet in Patients With Eosinophilic Esophagitis.

    • 2024-02-01
    • Clinical Trial
    • The American journal of gastroenterology 119(6)
    • • Amanda Huoy Wen Lim
      • Benjamin Ngoi
      • Griffith B Perkins
      • Stephanie Wong
      • Gail Whitelock
      • Plinio Hurtado
      • Andrew Ruszkiewicz
      • Thanh-Thao Adriana Le
      • Pravin Hissaria
      • Nam Quoc Nguyen

    • PubMed: 38299582
    • DOI: 10.14309/ajg.0000000000002678

    8 Insights on

    • Reduced Dysphagia
    • Reduced Dysphagia Symptom Score
    • Reduced EoE Endoscopic Reference Score
    • Reduced Eosinophilic Esophagitis Endoscopic Reference Score
    • Reduced Esophageal Eosinophil Count
    • Achieved Histological Remission
    • Reduced Histologic Remission
    • Reduced Food-Specific Immunoglobulin G4 Level

    • Moderate evidence

  • A biphasic response to blueberry supplementation on depressive symptoms in emerging adults: a double-blind randomized controlled trial.

    • 2024-02-01
    • RCT
    • European journal of nutrition 63(4)
    • • Martin Velichkov
      • Zsofia Bezur
      • Carien M van Reekum
      • Claire M Williams

    • PubMed: 38300292
    • DOI: 10.1007/s00394-023-03311-9

    8 Insights on

    • Improved Cognitive Function
    • Reduced Depression Symptoms
    • Reduced Anxiety
    • Reduced Oxidative Stress
    • Reduced Inflammation Markers
    • Improved Positive Affect
    • Reduced Anhedonia
    • Improved Neuroplasticity Biomarkers

    • High evidence
    • Rigorous Journal

  • Therapeutic effects of probiotics and herbal medications on oxalate nephrolithiasis: a mini systematic review.

    • 2024-02-01
    • Review
    • Iranian journal of microbiology 16(1)
    • • Hamed Taheri
      • Mohammad Mehdi Feizabadi
      • Reza Keikha
      • Rouhi Afkari

    • PubMed: 38682062
    • DOI: 10.18502/ijm.v16i1.14866

    3 Insights on

    • Reduced Renal Inflammation
    • Reduced Kidney Stone Formation
    • Reduced Urinary Oxalate Excretion

    • Low evidence

  • Iranian Traditional Medicine for Treatment of Attention Deficit Disorder with Hyperactivity in Children: A Systematic Review of Randomized Controlled Trials.

    • 2024-02-01
    • Review
    • Iranian journal of public health 53(2)
    • • Seyed Gholamreza Noorazar
      • Mohammadreza Mirzaei
      • Parinaz Kalejahi

    • PubMed: 38894827
    • DOI: 10.18502/ijph.v53i2.14913

    1 Insight on

    • Reduced ADHD Symptom Severity

    • Low evidence

  • Cost-effectiveness analysis of Manuka honey-Omega-3 combination treatments in treating oxidative stress of pediatric β-thalassemia major.

    • 2024-02-01
    • RCT · n = 50
    • European review for medical and pharmacological sciences 28(3)
    • • M Gamaleldin
      • I Abraham
      • M Meabed
      • A Elberry
      • S Abdelhalim
      • A Hussein
      • D Waggas
      • R Hussein

    • PubMed: 38375720
    • DOI: 10.26355/eurrev_202402_35353

    1 Insight on

    • Reduced Oxidative Stress

    • High evidence

  • Propionibacterium freudenreichii CIRM-BIA 129 mitigates colitis through S layer protein B-dependent epithelial strengthening.

    • 2024-02-01
    • Clinical Trial
    • American Journal of Physiology-Gastrointestinal and Liver Physiology 326(2)
    • • Marine Mantel
      • Tony Durand
      • A. Bessard
      • Ségolène Pernet
      • Julie Beaudeau
      • Juliana Guimaraes-Laguna
      • Marie-Bernadette Maillard
      • Éric Guédon
      • Michel Neunlist
      • Yves Le-Loir
      • Gwénaël Jan
      • M. Rolli-Derkinderen

    • PubMed: 37988603
    • DOI: 10.1152/ajpgi.00198.2023

    5 Insights on

    • Reduced Intestinal Permeability
    • Reduced Transepithelial Resistance
    • Maintained Crypt Length
    • Reduced Epithelial Breakdown
    • Reproduced Protective Effect via Extracellular Vesicles

    • Low evidence
    • Animal Study

  • Noniatrogenic Meningitis Caused by Streptococcus salivarius Associated with Early Esophageal Cancer and Early Gastric Cancer.

    • 2024-02-01
    • Case Report · n = 1
    • Internal Medicine 63(3)
    • • Miharu Yanagida
      • Y. Hosoi
      • Tatsuhiro Kawano
      • Yusuke Otake
      • Yoshiyuki Yamanaka
      • Takeshi Baba
      • Michiko Ito

    • PubMed: 37344440
    • DOI: 10.2169/internalmedicine.1304-22

    1 Insight on

    • Diagnosis of Meningitis

    • Low evidence
• February 5

  • Gut microbiota-derived LCA mediates the protective effect of PEDV infection in piglets.

    • 2024-02-05
    • Observational
    • Microbiome 12(1)
    • • Jun-Hong Xing
      • Tian-Ming Niu
      • Bo-Shi Zou
      • Gui-Lian Yang
      • Chun-Wei Shi
      • Qing-Song Yan
      • Ming-Jie Sun
      • Tong Yu
      • Shu-Min Zhang
      • Xi-Ze Feng
      • Shu-Hui Fan
      • Hai-Bin Huang
      • Jun-Hong Wang
      • Ming-Han Li
      • Yan-Long Jiang
      • Jian-Zhong Wang
      • Xin Cao
      • Nan Wang
      • Yan Zeng
      • Jing-Tao Hu
      • Di Zhang
      • Wu-Sheng Sun
      • Wen-Tao Yang
      • Chun-Feng Wang

    • PubMed: 38317217
    • DOI: 10.1186/s40168-023-01734-4

    1 Insight on

    • Improved Resistance to Porcine Epidemic Diarrhea Virus Infection

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Increased Accumulation of Ginsenosides in Panax ginseng Sprouts Cultivated with Kelp Fermentates.

    • 2024-02-05
    • Plants (Basel, Switzerland) 13(3)
    • • Kyung-Wuk Park
      • Jeong-Ho Kim
      • Beom-Gyun Jeong
      • Jun-Ki Park
      • Ho-Yeol Jang
      • Yun-Seo Oh
      • Kyung-Yun Kang

    • PubMed: 38337995
    • DOI: 10.3390/plants13030463

    1 Insight on

    • Increased Ginsenoside Content

    • Low evidence
• February 6

  • The effects of probiotic supplements on oxidative stress and inflammation in subjects with mild and moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled study.

    • 2024-02-06
    • RCT · n = 90
    • Inflammopharmacology 32(2)
    • • Camellia Akhgarjand
      • Zahra Vahabi
      • Sakineh Shab-Bidar
      • Aliarash Anoushirvani
      • Kurosh Djafarian

    • PubMed: 38319476
    • DOI: 10.1007/s10787-023-01427-2

    4 Insights on

    • Improved Quality of Life
    • Reduced Inflammation
    • Reduced Oxidative Stress
    • Improved Physical Activity Level

    • High evidence
• February 7

  • Immunomodulatory activity of heat-killed Lacticaseibacillus paracaseiMCC1849 based on the activation of plasmacytoid dendritic cells in the peripheral blood of healthy adults.

    • 2024-02-07
    • Food science & nutrition 12(5)
    • • Yiran Li
      • Takahiro Aoki
      • Sadahiro Iwabuchi
      • Satoshi Arai
      • Noriyuki Iwabuchi
      • Hideki Motobayashi
      • Miyuki Tanaka
      • Shinichi Hashimoto

    • PubMed: 38726445
    • DOI: 10.1002/fsn3.4009

    2 Insights on

    • Reduced Cold Symptoms
    • Increased Immune System Activation

    • Low evidence
• February 9

  • Influence of supplementation with iron and probiotic bacteria Lactobacillus plantarum and Lactobacillus curvatus on selected parameters of inflammatory state in rats on a high-fat iron-deficient diet.

    • 2024-02-09
    • n = 48
    • Journal of the science of food and agriculture 104(7)
    • • Katarzyna Skrypnik
      • Marcin Schmidt
      • Agnieszka Olejnik-Schmidt
      • Iskandar Azmy Harahap
      • Joanna Suliburska

    • PubMed: 38339838
    • DOI: 10.1002/jsfa.13329

    3 Insights on

    • Improved Lipid Profile
    • Improved Total Antioxidant Status
    • Reduced Inflammation

    • Low evidence
    • Animal Study
• February 11

  • The effect of oral synbiotics on the gut microbiota and inflammatory biomarkers in healthy adults: a systematic review and meta-analysis.

    • 2024-02-11
    • Meta-Analysis · n = 1,319
    • Nutrition reviews 83(2)
    • • Denelle J Cosier
      • Kelly Lambert
      • Elizabeth P Neale
      • Yasmine Probst
      • Karen Charlton

    • PubMed: 38341803
    • DOI: 10.1093/nutrit/nuae002

    3 Insights on

    • Increased Abundance of Bifidobacterium
    • Increased Abundance of Lactobacillus
    • Increased Propionic Acid Production

    • High evidence
• February 12

  • Saccharomyces cerevisiae derived postbiotic alters gut microbiome metabolism in the human distal colon resulting in immunomodulatory potential in vitro.

    • 2024-02-12
    • Frontiers in microbiology 15
    • • Cindy Duysburgh
      • Lisa Miclotte
      • Justin B Green
      • Kevin T Watts
      • Maria I Sardi
      • Anirikh Chakrabarti
      • Ehsan Khafipour
      • Massimo Marzorati

    • PubMed: 38410391
    • DOI: 10.3389/fmicb.2024.1358456

    4 Insights on

    • Improved Immune Function
    • Improved Gut Microbiome Composition
    • Increased Butyrate Production
    • Regulated Microbial Metabolism

    • Low evidence
• February 15

  • Bovine Colostrum in Increased Intestinal Permeability in Healthy Athletes and Patients: A Meta-Analysis of Randomized Clinical Trials.

    • 2024-02-15
    • Meta-Analysis
    • Digestive diseases and sciences 69(4)
    • • Parisa Hajihashemi
      • Fahimeh Haghighatdoost
      • Nazila Kassaian
      • Laleh Hoveida
      • Babak Tamizifar
      • Hassan Nili
      • Marzieh Rahim Khorasani
      • Peyman Adibi

    • PubMed: 38361147
    • DOI: 10.1007/s10620-023-08219-2

    2 Insights on

    • Reduced Intestinal Permeability
    • Reduced Intestinal Fatty Acid Binding Protein Level

    • High evidence
    • Rigorous Journal
• February 16

  • The Anti-Inflammatory and Curative Exponent of Probiotics: A Comprehensive and Authentic Ingredient for the Sustained Functioning of Major Human Organs.

    • 2024-02-16
    • Review
    • Nutrients 16(4)
    • • Muhammad Safiullah Virk
      • Muhammad Abdulrehman Virk
      • Yufeng He
      • Tabussam Tufail
      • Mehak Gul
      • Abdul Qayum
      • Abdur Rehman
      • Arif Rashid
      • John-Nelson Ekumah
      • Xu Han
      • Junxia Wang
      • Xiaofeng Ren

    • PubMed: 38398870
    • DOI: 10.3390/nu16040546

    1 Insight on

    • Improved Gastrointestinal Discomfort

    • Moderate evidence
    • Rigorous Journal

  • Association between dietary vitamin B1 intake and cognitive function among older adults: a cross-sectional study.

    • 2024-02-16
    • Observational · n = 2,422
    • Journal of translational medicine 22(1)
    • • Weiai Jia
      • Hemei Wang
      • Chao Li
      • Jingpu Shi
      • Fangfang Yong
      • Huiqun Jia

    • PubMed: 38365743
    • DOI: 10.1186/s12967-024-04969-3

    3 Insights on

    • Improved Cognitive Function
    • Improved Processing Speed
    • Improved Global Cognition

    • High evidence
• February 19

  • Probiotics' Effects in the Treatment of Anxiety and Depression: A Comprehensive Review of 2014-2023 Clinical Trials.

    • 2024-02-19
    • Review
    • Microorganisms 12(2)
    • • Ermis Merkouris
      • Theodora Mavroudi
      • Daniil Miliotas
      • Dimitrios Tsiptsios
      • Aspasia Serdari
      • Foteini Christidi
      • Triantafyllos K Doskas
      • Christoph Mueller
      • Konstantinos Tsamakis

    • PubMed: 38399815
    • DOI: 10.3390/microorganisms12020411

    2 Insights on

    • Reduced Depression Symptoms
    • Reduced Anxiety

    • Low evidence
• February 21

  • L-serine treatment in patients with GRIN-related encephalopathy: a phase 2A, non-randomized study.

    • 2024-02-21
    • Clinical Trial
    • Brain : a journal of neurology 147(5)
    • • Natalia Juliá-Palacios
      • Mireia Olivella
      • Mariya Sigatullina Bondarenko
      • Salvador Ibáñez-Micó
      • Beatriz Muñoz-Cabello
      • Olga Alonso-Luengo
      • Víctor Soto-Insuga
      • Deyanira García-Navas
      • Laura Cuesta-Herraiz
      • Patricia Andreo-Lillo
      • Sergio Aguilera-Albesa
      • Antonio Hedrera-Fernández
      • Elena González Alguacil
      • Rocío Sánchez-Carpintero
      • Fernando Martín Del Valle
      • Erika Jiménez González
      • Lourdes Cean Cabrera
      • Ines Medina-Rivera
      • Marta Perez-Ordoñez
      • Roser Colomé
      • Laura Lopez
      • María Engracia Cazorla
      • Montserrat Fornaguera
      • Aida Ormazabal
      • Itziar Alonso-Colmenero
      • Katia Sofía Illescas
      • Sol Balsells-Mejía
      • Rosanna Mari-Vico
      • Maria Duffo Viñas
      • Gerarda Cappuccio
      • Gaetano Terrone
      • Roberta Romano
      • Filippo Manti
      • Mario Mastrangelo
      • Chiara Alfonsi
      • Bruna de Siqueira Barros
      • Mathilde Nizon
      • Cathrine Elisabeth Gjerulfsen
      • Valeria L Muro
      • Daniela Karall
      • Fiona Zeiner
      • Silvia Masnada
      • Irene Peterlongo
      • Alfonso Oyarzábal
      • Ana Santos-Gómez
      • Xavier Altafaj
      • Ángeles García-Cazorla

    • PubMed: 38380699
    • DOI: 10.1093/brain/awae041

    8 Insights on

    • Improved Quality of Life
    • Improved Delayed Memory
    • Improved Cognitive Subdomain
    • Improved Gross Motor Function
    • Normalized EEG Pattern
    • Reduced Seizure Frequency
    • Increased Irritability
    • Increased Insomnia

    • Moderate evidence
• February 22

  • Effect of l-Carnitine Supplementation on Osteoarthritis: A Systematic Review.

    • 2024-02-22
    • Meta-Analysis · n = 619
    • Molecular nutrition & food research 68(8)
    • • Haiyang Kou
      • Bo Li
      • Zhili Wang
      • Jianbing Ma

    • PubMed: 38389158
    • DOI: 10.1002/mnfr.202300614

    5 Insights on

    • Reduced Inflammatory Markers
    • Reduced Pain
    • Improved Joint Function
    • Improved Western Ontario and McMaster Universities Osteoarthritis Index Total Score
    • Reduced Stiffness

    • High evidence
    • Rigorous Journal
• February 25

  • The effects of plum products consumption on lipid profile in adults: A systematic review and dose-response meta-analysis.

    • 2024-02-25
    • Review
    • Food science & nutrition 12(5)
    • • Azadeh Heydarian
      • Negin Tahvilian
      • Omid Asbaghi
      • Sahar Cheshmeh
      • Maryam Nadery
      • Naheed Aryaeian

    • PubMed: 38726435
    • DOI: 10.1002/fsn3.4000

    2 Insights on

    • Reduced Total Cholesterol Levels
    • Reduced Low-Density Lipoprotein Level

    • Low evidence
• February 26

  • Current perspectives on fenugreek bioactive compounds and their potential impact on human health: A review of recent insights into functional foods and other high value applications.

    • 2024-02-26
    • Review
    • Journal of food science 89(4)
    • • Muhammad H Alu'datt
      • Taha Rababah
      • Saleh Al-Ali
      • Carole C Tranchant
      • Sana Gammoh
      • Mohammad Alrosan
      • Stan Kubow
      • Thuan-Chew Tan
      • Salsabeel Ghatasheh

    • PubMed: 38407443
    • DOI: 10.1111/1750-3841.16970

    15 Insights on

    • Improved Immune Function
    • Reduced Blood Pressure
    • Reduced Blood Lipid Levels
    • Improved Liver Function
    • Reduced Cancer Risk
    • Reduced Blood Glucose Levels
    • Reduced Inflammation
    • Reduced Oxidative Stress
    • Improved Endocrine Function
    • Improved Digestive Function
    • Improved Reproductive Health
    • Improved Central Nervous System Function
    • Improved Cardiac Function
    • Reduced Pain
    • Improved Inflammatory Skin Condition

    • Moderate evidence
    • Rigorous Journal

  • Effects of flaxseed oil supplementation on metaphase II oocyte rates in IVF cycles with decreased ovarian reserve: a randomized controlled trial.

    • 2024-02-26
    • RCT · n = 110
    • Frontiers in endocrinology 15
    • • Qi Chu
      • Yue-Xin Yu
      • Jing-Zi Zhang
      • Yi-Tong Zhang
      • Jia-Ping Yu

    • PubMed: 38469148
    • DOI: 10.3389/fendo.2024.1280760

    9 Insights on

    • Reduced Recombinant Human Follicle-Stimulating Hormone Dosage
    • Reduced Stimulation Time
    • Increased Peak Estradiol Concentration
    • Increased Metaphase II Oocyte Rate
    • Increased Fertilization Rate
    • Increased Cleavage Rate
    • Increased High-Quality Embryo Rate
    • Increased Blastocyst Formation Rate
    • Increased Embryo Implantation Rate

    • High evidence
    • Large Human Trial
• February 27

  • The effect of bovine dairy products and their components on the incidence and natural history of infection: a systematic literature review.

    • 2024-02-27
    • Systematic Review
    • Nutrition journal 23(1)
    • • Meghan Mitchell
      • Mina Suh
      • Naushin Hooda
      • Lauren C Bylsma
      • Sarah S Cohen

    • PubMed: 38413931
    • DOI: 10.1186/s12937-024-00923-7

    2 Insights on

    • Reduced Virological Burden
    • Reduced Hepatitis C Viral Load

    • High evidence
• February 28

  • Local and Systemic Effects of Bioactive Food Ingredients: Is There a Role for Functional Foods to Prime the Gut for Resilience?

    • 2024-02-28
    • Review
    • Foods (Basel, Switzerland) 13(5)
    • • Emma F Jacquier
      • Marcel van de Wouw
      • Elena Nekrasov
      • Nikhat Contractor
      • Amira Kassis
      • Diana Marcu

    • PubMed: 38472851
    • DOI: 10.3390/foods13050739

    4 Insights on

    • Improved Skin Hydration
    • Reduced Transepidermal Water Loss
    • Improved Gut Health
    • Improved Gut Resilience

    • Low evidence
• Undated – 6 supplement studies

  • Lactobacillus amylovorus Promotes Lactose Utilization in Small Intestine and Enhances Intestinal Barrier Function in Intrauterine Growth Restricted Piglets.

    • 2024-02
    • Clinical Trial
    • The Journal of nutrition 154(2)
    • • Yujun Wu
      • Xiaoyi Liu
      • Youwei Zou
      • Xiangyu Zhang
      • Zhenyu Wang
      • Jie Hu
      • Dandan Han
      • Jinbiao Zhao
      • Zhaolai Dai
      • Junjun Wang

    • PubMed: 38072153
    • DOI: 10.1016/j.tjnut.2023.12.004

    3 Insights on

    • Improved Intestinal Barrier Function
    • Improved Growth Performance
    • Unchanged Lactose Utilization

    • Moderate evidence

  • The Effects of L-Carnitine Supplementation on Blood Pressure in Adults: A Systematic Review and Dose-response Meta-analysis.

    • 2024-02
    • Meta-Analysis · n = 1,412
    • Clinical therapeutics 46(2)
    • • Shiva Rahimipour Anaraki
      • Yasaman Aali
      • Mahlagha Nikbaf-Shandiz
      • Niloufar Rasaei
      • Alireza Khadem
      • Hossein Bahari
      • Zeinab Khalse
      • Samira Rastgoo
      • Farideh Shiraseb
      • Omid Asbaghi

    • PubMed: 38101999
    • DOI: 10.1016/j.clinthera.2023.11.002

    2 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure

    • High evidence

  • Antimutagenic activity of different forms of Bifidobacterium lactis probiotic against aflatoxin B1 by Ames method.

    • 2024-02
    • Toxicon : official journal of the International Society on Toxinology 239
    • • Mehdi Pakizeh
      • Leila Nouri
      • Mohammad Hossein Azizi

    • PubMed: 38211806
    • DOI: 10.1016/j.toxicon.2024.107608

    3 Insights on

    • Reduced Fecal Mutagenicity
    • No Mutagenic Effects
    • No Mutagenicity

    • Low evidence

  • The role of probiotics and synbiotics on treatment of gestational diabetes: systematic review and meta-analysis.

    • 2024-02
    • Review · n = 896
    • AJOG global reports 4(1)
    • • Arresta Vitasatria Suastika
      • I Gde Raka Widiana
      • Ni Nengah Dwi Fatmawati
      • Ketut Suastika
      • Ivana Beatrice Paulus
      • I Nengah Sujaya

    • PubMed: 38322777
    • DOI: 10.1016/j.xagr.2023.100285

    9 Insights on

    • Improved Insulin Sensitivity
    • Reduced Triglyceride Levels
    • Reduced Insulin Levels
    • Improved Glycemic Control
    • Reduced Inflammation
    • Reduced Fasting Blood Glucose Levels
    • Improved Insulin Resistance
    • Improved Triglyceride Levels
    • Improved Glycemia

    • High evidence

  • Efficacy of parsley seed-supplemented bread in improving serum osteopontin level and renal health in obese women: A nutritional intervention study.

    • 2024-02
    • Clinical Trial · n = 85
    • Clinical nutrition ESPEN 59
    • • Hend A Essa
      • Salwa M El Shebini
      • Maha I A Moaty
      • Nihad H Ahmed
      • Ahmed M S Hussein
      • Magda S Mohamed

    • PubMed: 38220388
    • DOI: 10.1016/j.clnesp.2023.12.022

    7 Insights on

    • Increased Interleukin-10 Levels
    • Reduced Interleukin-1β Levels
    • Improved Blood Lipid Profile
    • Reduced Creatinine Level
    • Reduced Osteopontin Level
    • Increased eGFR
    • Increased Creatinine Clearance

    • High evidence

  • Sunflower seed extract supplementation reduces body fat in adults with obesity: A double-blind, randomized, placebo-controlled trial.

    • 2024-02
    • RCT · n = 100
    • Nutrition research (New York, N.Y.) 122
    • • Ha-Na Kim
      • Yun-Ah Lee
      • Sang-Wook Song

    • PubMed: 38217909
    • DOI: 10.1016/j.nutres.2023.12.004

    4 Insights on

    • Reduced Body Mass Index
    • Reduced Body Weight
    • Reduced Hip Circumference
    • Reduced Body Fat Mass

    • High evidence
    • Large Human Trial