April 2020 Supplement Research Papers

• April 1

  • Long-term combined administration of Bifidobacterium bifidum TMC3115 and Lactobacillus plantarum 45 alleviates spatial memory impairment and gut dysbiosis in APP/PS1 mice.

    • 2020-04-01
    • RCT · n = 4
    • FEMS Microbiology Letters 367(7)
    • • Feng Wang
      • Tong Xu
      • Yujie Zhang
      • T. Zheng
      • Yunling He
      • F. He
      • Yugang Jiang

    • PubMed: 32239209
    • DOI: 10.1093/femsle/fnaa048

    2 Insights on

    • Improved Gut Microbiota Diversity
    • Improved Cognitive Function

    • Low evidence
    • Animal Study

  • Weight-Reducing Effect of Lactobacillus Plantarum ZJUFT17 Isolated from Sourdough Ecosystem

    • 2020-04-01
    • Clinical Trial
    • Nutrients 12(4)
    • • Tongjie Liu
      • Yang Li
      • Minjie Zhao
      • Q. Mo
      • Feng-qin Feng

    • PubMed: 32244807
    • DOI: 10.3390/nu12040977

    5 Insights on

    • Improved Insulin Sensitivity
    • Improved Lipid Profile
    • Reduced Food Intake
    • Reduced Weight Gain
    • Reduced Systemic Inflammatory Response

    • Low evidence
    • Animal Study
• April 2

  • Bifidobacterium longum subsp. longum remodeled Roseburia and Phosphatidylserine levels, meliorated intestinal disorders and liver metabolic abnormalities induced by high-fat diet.

    • 2020-04-02
    • Clinical Trial
    • Journal of Agricultural and Food Chemistry 68(16)
    • • Tao Wu
      • Mengzhen Sun
      • R. Liu
      • Wenjie Sui
      • Jiaojiao Zhang
      • Jinjin Yin
      • Jiangu Zhu
      • S. Fang
      • Min Zhang

    • PubMed: 32237746
    • DOI: 10.1021/acs.jafc.0c00717

    17 Insights on

    • Reduced Body Weight
    • Reduced Triglyceride Levels
    • Improved Liver Function
    • Reduced Serum Cholesterol Levels
    • Reduced LDL Cholesterol
    • Reduced Hepatic Fat Accumulation
    • Improved Gut Microbiota Balance
    • Reduced Liver Fat Vacuolization
    • Reduced Epididymal Fat Mass
    • Improved Glycerophospholipid Metabolism
    • Alleviated D-Tryptophan Levels
    • Improved Gut Microbiome Composition
    • Reduced Liver Fat
    • Reduced Weight Gain
    • Balanced Gut Microbiota
    • Reduced D-Tryptophan Levels
    • Regulated Liver Glycerophospholipid Metabolism

    • Low evidence
    • Animal Study

  • Influence of Lactobacillus kefiri on Intestinal Microbiota and Fecal IgA Content of Healthy Dogs

    • 2020-04-02
    • Clinical Trial · n = 10
    • Frontiers in Veterinary Science 7
    • • A. Gaspardo
      • A. Zannoni
      • S. Turroni
      • M. Barone
      • M. C. Sabetti
      • R. Zanoni
      • M. Forni
      • P. Brigidi
      • M. Pietra

    • PubMed: 32300601
    • DOI: 10.3389/fvets.2020.00146

    1 Insight on

    • Unchanged Fecal IgA Levels

    • Low evidence
    • Animal Study
• April 3

  • Lactobacillus acidophilus and L. plantarum improve health status, modulate gut microbiota and innate immune response of marron (Cherax cainii)

    • 2020-04-03
    • RCT · n = 36
    • Scientific Reports 10(1)
    • • Md Javed Foysal
      • R. Fotedar
      • M. Siddik
      • A. Tay

    • PubMed: 32246011
    • DOI: 10.1038/s41598-020-62655-y

    9 Insights on

    • Improved Gut Microbiota Composition
    • Altered Gut Microbial Community
    • Enhanced Innate Immune Function
    • Improved Hemolymph Parameters
    • Improved Hepatopancreas Health
    • Improved Intestinal Microbial Composition
    • Improved Muscle Biochemical Composition
    • Increased Gut Microvilli Count
    • Improved Microbial Community Composition

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Effects of Lactobacillus rhamnosus ATCC 7469 on Different Parameters Related to Health Status of Rainbow Trout (Oncorhynchus mykiss) and the Protection Against Yersinia ruckeri

    • 2020-04-03
    • Probiotics and Antimicrobial Proteins 12(4)
    • • Yalda Hooshyar
      • A. Abedian Kenari
      • H. Paknejad
      • H. Gandomi

    • PubMed: 32246325
    • DOI: 10.1007/s12602-020-09645-8

    9 Insights on

    • Improved Immune Response
    • Reduced Whole Body Fat
    • Improved Weight Gain
    • Reduced Blood Cholesterol
    • Increased Serum Total Protein Levels
    • Reduced Blood Serum Cholesterol
    • Improved Survival Rate Against Infection
    • Improved Whole-Body Protein
    • Reduced Whole-Body Lipid Levels

    • Low evidence

  • Effects of Palmaria palmata on lipid metabolism and glycemic control in participants with hypercholesterolemia in a randomized double-blind placebo-controlled trial.

    • 2020-04-03
    • RCT · n = 104
    • Phytotherapy research : PTR 34(9)
    • • Takahiro Takase
      • Akinobu Nakamura
      • Hideaki Miyoshi
      • Minori Koga
      • Atsuhito Toyomaki
      • Ichiro Kusumi
      • Rikako Kino
      • Yasuyuki Konishi
      • Yoshinobu Kiso
      • Tatsuya Atsumi

    • PubMed: 32242987
    • DOI: 10.1002/ptr.6680

    1 Insight on

    • Reduced Triglyceride Levels

    • High evidence
    • Large Human Trial
• April 6

  • Lactobacillus pentosus S-PT84 Prevents Low-Grade Chronic Inflammation-Associated Metabolic Disorders in a Lipopolysaccharide and High-Fat Diet C57/BL6J Mouse Model.

    • 2020-04-06
    • Clinical Trial
    • Journal of Agricultural and Food Chemistry 68(15)
    • • Yuhan Zeng
      • Hua Zhang
      • R. Tsao
      • Y. Mine

    • PubMed: 32250610
    • DOI: 10.1021/acs.jafc.0c00118

    3 Insights on

    • Improved Gut Integrity
    • Maintained Metabolic Homeostasis
    • Reduced Systemic Inflammatory Response

    • Low evidence
    • Animal Study
• April 8

  • Harnessing Microbes for Sustainable Development: Food Fermentation as a Tool for Improving the Nutritional Quality of Alternative Protein Sources.

    • 2020-04-08
    • Review
    • Nutrients 12(4)
    • • Anna Kårlund
      • Carlos Gómez-Gallego
      • Jenni Korhonen
      • Outi-Maaria Palo-Oja
      • Hani El-Nezami
      • Marjukka Kolehmainen

    • PubMed: 32276384
    • DOI: 10.3390/nu12041020

    6 Insights on

    • Improved Protein Digestion
    • Improved Micronutrient Status
    • Improved Nutritional Value
    • Improved Food Safety
    • Improved Nutritional Quality
    • Improved Micronutrient Availability

    • Moderate evidence
    • Rigorous Journal
• April 9

  • Lactobacillus salivarius Subspecies salicinius SA-03 is a New Probiotic Capable of Enhancing Exercise Performance and Decreasing Fatigue

    • 2020-04-09
    • Microorganisms 8(4)
    • • Mon-Chien Lee
      • Y. Hsu
      • H. Ho
      • Shih‐Hung Hsieh
      • Y. Kuo
      • Hsin‐Ching Sung
      • Chi-Chang Huang

    • PubMed: 32283729
    • DOI: 10.3390/microorganisms8040545

    13 Insights on

    • Improved Endurance
    • Reduced Serum Ammonia Levels
    • Reduced Creatine Kinase Levels
    • Reduced Blood Urea Nitrogen Levels
    • Improved Exercise Performance
    • Improved Muscle Strength
    • Enhanced Glycogen Storage
    • Reduced Lactate Levels
    • Reduced Ammonia Levels
    • Reduced Post-Exercise Lactate Levels
    • Increased Hepatic Glycogen Storage
    • Reduced Fatigue
    • Reduced Blood Lactate Levels

    • Low evidence
    • Rigorous Journal

  • Fecal Recovery of Probiotics Administered as a Multi-Strain Formulation during Antibiotic Treatment.

    • 2020-04-09
    • RCT
    • Biomedicines 8(4)
    • • Sofia D Forssten
      • Nicolas Yeung
      • Arthur C Ouwehand

    • PubMed: 32283645
    • DOI: 10.3390/biomedicines8040083

    1 Insight on

    • Increased Persistence of Probiotics in Fecal Matter

    • High evidence
• April 13

  • Molecular Routes to Specific Identification of the Lactobacillus Casei Group at the Species, Subspecies and Strain Level

    • 2020-04-13
    • International Journal of Molecular Sciences 21(8)
    • • P. Jarocki
      • Elwira Komoń-Janczara
      • A. Glibowska
      • M. Dworniczak
      • Monika Pytka
      • A. Korzeniowska-Kowal
      • A. Wzorek
      • M. Kordowska-Wiater

    • PubMed: 32294944
    • DOI: 10.3390/ijms21082694

    8 Insights on

    • Reduced Diarrhea Rate
    • Improved Intestinal Mucosal Immunity
    • Reduced Constipation
    • Reduced Lactose Intolerance Symptoms
    • Reduced Cancer Risk
    • Reduced Blood Cholesterol
    • Reduced Effects of Inflammatory Bowel Disease
    • Reduced Food Allergy Incidence

    • Low evidence
• April 15

  • Supplemental Clostridium butyricum Modulates Lipid Metabolism Through Shaping Gut Microbiota and Bile Acid Profile of Aged Laying Hens

    • 2020-04-15
    • Frontiers in Microbiology 11
    • • Wei-wei Wang
      • Jing Wang
      • Haijun Zhang
      • Shu-geng Wu
      • G. Qi

    • PubMed: 32351471
    • DOI: 10.3389/fmicb.2020.00600

    5 Insights on

    • Reduced Liver Fat Deposition
    • Reduced Free Fatty Acid Levels
    • Elevated Hormone Levels
    • Enhanced Hepatic Fatty Acid Oxidation
    • Modulated Bile Acid Profile in Ileum

    • Low evidence
• April 16

  • Effects of Clostridium butyricum and Enterococcus faecalis on growth performance, immune function, intestinal morphology, volatile fatty acids, and intestinal flora in a piglet model.

    • 2020-04-16
    • RCT · n = 180
    • Food & Function 10(12)
    • • Kangli Wang
      • G. Cao
      • Haoran Zhang
      • Qing Li
      • Caimei Yang

    • PubMed: 31793606
    • DOI: 10.1039/c9fo01650c

    4 Insights on

    • Improved Intestinal Flora Diversity
    • Improved Intestinal Morphology
    • Improved Immune Function
    • Improved Growth Performance

    • Low evidence
    • Highly Cited
    • Animal Study

  • Integrated metabolomic and proteomics profiling reveals the promotion of Lactobacillus reuteri LR1 on amino acid metabolism in the gut-liver axis of weaned pigs.

    • 2020-04-16
    • Clinical Trial
    • Food & Function 10(11)
    • • H. Yi
      • G. Yang
      • Yunxia Xiong
      • Qiwen Wu
      • Hao Xiao
      • XiaoLu Wen
      • Xuefen Yang
      • Li Wang
      • Zong-yong Jiang

    • PubMed: 31651917
    • DOI: 10.1039/c9fo01781j

    2 Insights on

    • Enhanced Amino Acid Metabolism
    • Increased mTORC1 Activation

    • Low evidence
    • Animal Study
• April 19

  • A Randomized Controlled Open Label Crossover Trial to Study Vaginal Colonization of Orally Administered Lactobacillus Reuteri RC-14 and Rhamnosus GR-1 in Pregnant Women at High Risk for Preterm Labor

    • 2020-04-19
    • RCT · n = 40
    • Nutrients 12(4)
    • • Enav Yefet
      • R. Colodner
      • M. Strauss
      • Yifat Gam Ze Letova
      • Z. Nachum

    • PubMed: 32325794
    • DOI: 10.3390/nu12041141

    1 Insight on

    • Reduced Vaginal Colonization

    • High evidence
• April 20

  • Safety and Effect of a Low- and High-Dose Multi-Strain Probiotic Supplement on Microbiota in a General Adult Population: A Randomized, Double-Blind, Placebo-Controlled Study

    • 2020-04-20
    • RCT
    • Journal of Dietary Supplements 18(3)
    • • A. Tremblay
      • Asmaa Fatani
      • A. Ford
      • A. Piano
      • Varuni Nagulesapillai
      • J. Auger
      • Chad W. MacPherson
      • M. Christman
      • T. Tompkins
      • W. Dahl

    • PubMed: 32306803
    • DOI: 10.1080/19390211.2020.1749751

    2 Insights on

    • No Adverse Events Observed
    • No Significant Change in Gastrointestinal or General Wellbeing

    • High evidence

  • Reduction in the Choking Phenomenon in Elite Diving Athletes Through Changes in Gut Microbiota Induced by Yogurt Containing Bifidobacterium animalis subsp. lactis BB-12: A Quasi Experimental Study.

    • 2020-04-20
    • Clinical Trial · n = 20
    • Microorganisms 8(4)
    • • Weizhong Dong
      • Ying Wang
      • Shuaixiong Liao
      • Minghang Lai
      • Li Peng
      • Gang Song

    • PubMed: 32326047
    • DOI: 10.3390/microorganisms8040597

    4 Insights on

    • Increased Bifidobacteriaceae Abundance
    • Reduced Performance Choking Under Pressure
    • Improved Athletic Performance
    • Reduced Choking Index

    • Moderate evidence
• April 21

  • Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized, Placebo-Controlled Study

    • 2020-04-21
    • RCT · n = 251
    • Nutrients 12(4)
    • • E. Lewis
      • Joseph M. Antony
      • David C. Crowley
      • A. Piano
      • R. Bhardwaj
      • T. Tompkins
      • M. Evans

    • PubMed: 32326347
    • DOI: 10.3390/nu12041159

    15 Insights on

    • Improved Bowel Movement Frequency
    • Increased Bowel Movement Frequency
    • Improved Quality of Life
    • Improved Social Functioning
    • Decreased Spontaneous Bowel Movement Frequency in IBS-D
    • Increased Complete Spontaneous Bowel Movements
    • Improved Psychological Well-being
    • Reduced Severity of Gastrointestinal Disorders
    • Reduced Bowel Movement Frequency in IBS-D
    • Improved Emotional Well-Being Quality of Life
    • Improved Social Functioning Quality of Life
    • Reduced Spontaneous Bowel Movements in IBS-D
    • Improved Emotional Well-being
    • Improved Irritable Bowel Syndrome Symptom Severity
    • Reduced Bowel Movement Frequency

    • High evidence
• April 23

  • A double-blind, randomized, crossover trial protocol of whole hemp seed protein and hemp seed protein hydrolysate consumption for hypertension.

    • 2020-04-23
    • RCT
    • Trials 21(1)
    • • Maryam Samsamikor
      • Dylan Mackay
      • Rebecca C Mollard
      • Rotimi E Aluko

    • PubMed: 32326966
    • DOI: 10.1186/s13063-020-4164-z

    4 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure
    • Reduced Pulse Wave Velocity
    • Reduced Augmentation Index

    • High evidence
• April 26

  • Lactobacillus plantarum NA136 ameliorates nonalcoholic fatty liver disease by modulating gut microbiota, improving intestinal barrier integrity, and attenuating inflammation

    • 2020-04-26
    • Clinical Trial
    • Applied Microbiology and Biotechnology 104(12)
    • • Zijian Zhao
      • Long Chen
      • Yujuan Zhao
      • Chao Wang
      • Cui-cui Duan
      • Ge Yang
      • Chunhua Niu
      • Shengyu Li

    • PubMed: 32335723
    • DOI: 10.1007/s00253-020-10633-9

    7 Insights on

    • Improved Insulin Sensitivity
    • Improved Intestinal Barrier Function
    • Reduced Inflammation Levels
    • Enhanced Probiotic Growth
    • Corrected Gut Microbiota Disorders
    • Improved NAFLD
    • Reduced Pathogenic Bacteria

    • Low evidence
    • Animal Study
• April 28

  • Potential Health-Promoting Benefits of Paraprobiotics, Inactivated Probiotic Cells.

    • 2020-04-28
    • Review
    • Journal of microbiology and biotechnology 30(4)
    • • Shahina Akter
      • Jong-Hyun Park
      • Hoo Kil Jung

    • PubMed: 31986247
    • DOI: 10.4014/jmb.1911.11019

    3 Insights on

    • Reduced Blood Pressure
    • Reduced Cold Symptoms
    • Reduced Skin Dryness Symptoms

    • Low evidence

  • Influenza infection elicits an expansion of gut population of endogenous Bifidobacterium animalis which protects mice against infection

    • 2020-04-28
    • Clinical Trial
    • Genome Biology 21(1)
    • • Qiang Zhang
      • Jin Hu
      • Jia-Wu Feng
      • Xiaotong Hu
      • Ting Wang
      • Wen-xiao Gong
      • Kun Huang
      • Yi-Xiong Guo
      • Zhong Zou
      • Xian Lin
      • Run Zhou
      • Yuting Yuan
      • A. Zhang
      • Hong Wei
      • Gang Cao
      • Chen Liu
      • Lingling Chen
      • M. Jin

    • PubMed: 32345342
    • DOI: 10.1186/s13059-020-02007-1

    3 Insights on

    • Enhanced Influenza Resistance
    • Reduced Severity of Influenza Infection
    • Reduced Influenza Symptoms

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Antioxidant and Anti-Inflammatory Effect of Probiotic Lactobacillus plantarum KU15149 Derived from Korean Homemade Diced-Radish Kimchi

    • 2020-04-28
    • Journal of Microbiology and Biotechnology 30(4)
    • • Kyoung Jun Han
      • Ji-Eun Lee
      • N. Lee
      • H. Paik

    • PubMed: 32238771
    • DOI: 10.4014/jmb.2002.02052

    10 Insights on

    • Reduced Inflammatory Response
    • Reduced Inflammatory Markers
    • Reduced Intestinal Cell Adhesion
    • Increased Antioxidant Activity
    • Enhanced Antioxidant Activity
    • Improved Intestinal Cell Adhesion
    • Improved Probiotic Functionality
    • Increased Gastric Survival Rate
    • Absence of Antibiotic Resistance
    • Reduced Production of Carcinogenic Enzymes

    • Low evidence
• Undated – 5 supplement studies

  • Effects of dietary probiotic (Pediococcus acidilactici) supplementation on productive performance, egg quality, and body composition in laying hens fed diets varying in energy density

    • 2020-04
    • Poultry Science 99(4)
    • • D. Mikulski
      • J. Jankowski
      • M. Mikulska
      • V. Demey

    • PubMed: 32241513
    • DOI: 10.1016/j.psj.2019.11.046

    5 Insights on

    • Improved Egg Weight
    • Improved Eggshell Quality
    • Improved Layer Performance
    • Improved Energy Utilization
    • Achieved Bioequivalence in Performance Parameters

    • Low evidence
    • Rigorous Journal

  • Oral intake of Streptococcus thermophilus improves knee osteoarthritis degeneration: A randomized, double-blind, placebo-controlled clinical study

    • 2020-04
    • RCT · n = 80
    • Heliyon 6(4)
    • • Jianwei Lyu
      • Ting-Ming Wang
      • Yen-Hao Chen
      • Shu-Xuan Chang
      • Ming-Shiang Wu
      • Yung-Hao Lin
      • Yung-Hsiang Lin
      • Chen-Meng Kuan

    • PubMed: 32368640
    • DOI: 10.1016/j.heliyon.2020.e03757

    5 Insights on

    • Reduced C-Reactive Protein Levels
    • Reduced Serum Collagen Type II C-Telopeptide (sCTX-II)
    • Improved KOA Symptoms
    • Reduced Serum C-reactive Protein Levels
    • Slowed Progression of Knee Osteoarthritis

    • High evidence

  • L-Carnosine combination therapy for major depressive disorder: A randomized, double-blind, placebo-controlled trial.

    • 2020-04
    • RCT
    • Journal of affective disorders 267
    • • Behin Araminia
      • Mohammadreza Shalbafan
      • Amirhosein Mortezaei
      • Elham Shirazi
      • Salomeh Ghaffari
      • Erfan Sahebolzamani
      • Seyyed Hosein Mortazavi
      • Behnam Shariati
      • Mehrdad Eftekhar Ardebili
      • Ali Aqamolaei
      • Sina Naderi
      • Shahin Akhondzadeh

    • PubMed: 32063564
    • DOI: 10.1016/j.jad.2020.02.020

    3 Insights on

    • Reduced Depression Symptoms
    • Improved Response to Treatment
    • Improved Remission Rate

    • High evidence

  • Effects of recombinant Lactobacillus casei on growth performance, immune response and disease resistance in crucian carp, Carassius auratus.

    • 2020-04
    • Clinical Trial
    • Fish & Shellfish Immunology 99
    • • Yi‐di Kong
      • Min Li
      • Jiaxin Tian
      • Linhui Zhao
      • Yuanhuan Kang
      • Lei Zhang
      • Guiqin Wang
      • Xiaofeng Shan

    • PubMed: 32032762
    • DOI: 10.1016/j.fsi.2020.02.008

    4 Insights on

    • Increased PMN Cell Phagocytic Capacity
    • Improved Immune Response
    • Improved Growth Performance
    • Enhanced Disease Resistance

    • Low evidence
    • Animal Study

  • Lactobacillus fermentum CECT5716 supplementation in rats during pregnancy and lactation affects breast milk composition.

    • 2020-04
    • Journal of Dairy Science 103(4)
    • • Ignasi Azagra-Boronat
      • A. Tres
      • M. Massot-Cladera
      • À. Franch
      • M. Castell
      • F. Guardiola
      • F. Pérez-Cano
      • M. J. Rodríguez-Lagunas

    • PubMed: 32008776
    • DOI: 10.3168/jds.2019-17384

    13 Insights on

    • Increased Immunoglobulin A Levels
    • Increased Polyunsaturated Fatty Acids in Milk
    • Elevated IgA Levels in Milk
    • Increased Immunoglobulin M Levels
    • Increased PUFA Levels in Breast Milk
    • Reduced Palmitic Acid Levels in Breast Milk
    • Increased Immunoglobulin A Levels in Breast Milk
    • Elevated Serum Immunoglobulin Levels
    • Improved Fatty Acid Composition
    • Improved Milk Fatty Acid Profile
    • Improved Fatty Acid Profile
    • Decreased Proportion of Palmitic Acid in Milk
    • Increased Milk IgA Levels

    • Low evidence
    • Rigorous Journal