May 2026 Supplement Research Papers

• May 1

  • Efficacy and Safety of a Dual-Wavelength 589/1319 nm Laser for the Treatment of Acne Erythema: A Split-Face Randomized Controlled Trial.

    • 2026-05-01
    • RCT
    • Journal of cosmetic dermatology 25(5)
    • • Suphagan Boonpethkaew
      • Pimsiri Anansiripun
      • Warittha Maitrisathit
      • Yanisa Ratanapokasatit
      • Sonphet Chirasuthat
      • Panrudee Wechsuruk
      • Penpun Wattanakrai

    • PubMed: 42087432
    • DOI: 10.1111/jocd.70894

    1 Insight on

    • Reduced Acne Erythema

    • High evidence

  • A child with cobalamin C deficiency caused by complex heterozygous variation of c.567dupT and c.80A > G complicated with pulmonary arterial hypertension and hydrocephalus: A case report and literature review.

    • 2026-05-01
    • Review
    • Medicine 105(18)
    • • Xuxia Cui
      • Yajing Zhong
      • Chongjuan Yin

    • PubMed: 42065149
    • DOI: 10.1097/md.0000000000048340

    4 Insights on

    • Improved Renal Function
    • Improved Developmental Milestone
    • Reduced Pulmonary Artery Systolic Pressure
    • No Progression of Hydrocephalus

    • Low evidence

  • Single intake of matcha increases brown adipose tissue activity in young women with low thermogenesis.

    • 2026-05-01
    • RCT · n = 30
    • Physiological reports 14(9)
    • • Hirokazu Taniguchi
      • Chisaki Hachikawa
      • Sana Iwase
      • Shinsuke Nirengi
      • Tomomi Nagahata

    • PubMed: 42068075
    • DOI: 10.14814/phy2.70896

    1 Insight on

    • Increased Brown Adipose Tissue Activity

    • High evidence
• May 2

  • Effects of Dietary Nitrate and Caffeine on End Power and Work Above End Power During a 3 min All-Out Test in Trained Male Cyclists.

    • 2026-05-02
    • RCT
    • Nutrients 18(9)
    • • Anthony M Hagele
      • Kyle L Sunderland
      • Petey W Mumford
      • Chad M Kerksick

    • PubMed: 42124064
    • DOI: 10.3390/nu18091463

    5 Insights on

    • Improved Mean Power
    • Improved Work Capacity
    • Improved Peak Power
    • Improved Endurance Power
    • Improved Work Above End Power

    • High evidence
    • Rigorous Journal
• May 17

  • Multicenter retrospective observational study on the clinical effectiveness of butyrate-producing Clostridium butyricum containing probiotics in patients with COVID-19.

    • 2026-05-17
    • Observational
    • Virulence 17(1)
    • • Yoshihiko Morikawa
      • Hideo Kato
      • Takumi Umemura
      • Jun Hirai
      • Yuichi Shibata
      • Mao Hagihara
      • Nobuhiro Asai
      • Hiroshige Mikamo
      • Takuya Iwamoto

    • PubMed: 42127027
    • DOI: 10.1080/21505594.2026.2673650

    3 Insights on

    • Reduced Duration of Mechanical Ventilation
    • Reduced In-hospital Mortality
    • Reduced Incidence of Secondary Bacterial Pneumonia

    • Low evidence
• May 26

  • Exploratory Studies on the Potential Health Benefits of Spices and Herbs.

    • 2026-05-26
    • Review
    • Nutrition reviews 84(Supplement_1)
    • • Guy H Johnson

    • PubMed: 42186284
    • DOI: 10.1093/nutrit/nuaf247

    6 Insights on

    • Reduced Inflammatory Markers
    • Reduced Oxidative Stress Markers
    • Increased Energy Expenditure
    • Improved Working Memory Speed
    • Reduced DNA Strand Break in Peripheral Blood Mononuclear Cell
    • Improved Substrate Utilization

    • Low evidence
• Undated – 14 supplement studies

  • Influence of dietary supplementation with two distinct probiotic strains, Bifidobacterium longum R0175 and Lacticaseibacillus rhamnosus JB-1, on seizure susceptibility and valproate response: Behavioral and biochemical studies in mice.

    • 2026-05
    • Nutrition (Burbank, Los Angeles County, Calif.) 145
    • • Piotr Wlaź
      • Karolina Skonieczna-Żydecka
      • Adrian Wiater
      • Daniel Styburski
      • Małgorzata Majewska
      • Anna Boguszewska-Czubara
      • Elżbieta Wyska
      • Alan González-Ibarra
      • Nikola Gapińska
      • Dorota Luchowska-Kocot
      • Renata Żelazowska
      • Marcin Grąz
      • Katarzyna Socała

    • PubMed: 41576857
    • DOI: 10.1016/j.nut.2025.113083

    1 Insight on

    • Increased threshold for myoclonic seizures

    • Low evidence
    • Animal Study

  • Advocating gut-retina connection and microbiota mediated pathways in management of age-related macular degeneration: Preclinical to clinical perspective.

    • 2026-05
    • Review
    • Ageing research reviews 117
    • • Pramod V Waghmare
      • Kaustubh Ajit Kolekar
      • Bushra Bashir
      • Popat S Kumbhar
      • Kalpana S Patil
      • Gaurav Gupta
      • Parteek Prasher
      • Saurabh Kumar Jha
      • John Disouza
      • Shailendra S Gurav
      • Kamal Dua
      • Sachin Kumar Singh

    • PubMed: 41759744
    • DOI: 10.1016/j.arr.2026.103071

    4 Insights on

    • Improved Gut Homeostasis
    • No Human Health Outcome Reported
    • Retina Protection
    • Reduced Age-Related Macular Degeneration Progression

    • Low evidence

  • Functional bread containing synbiotic microcapsules loaded with Lactobacillus delbrueckii subsp. bulgaricus and enzymatic levan.

    • 2026-05
    • Food chemistry 511
    • • Pınar Aytar Çelik
      • Dilan Barut Yavaş
      • Benay Çolak
      • Belma Nural Yaman
      • Özlem Erdal Altıntaş
      • Seda Doğan
      • Arzu Akın
      • Ebru Toksoy Öner
      • Ahmet Çabuk

    • PubMed: 41812452
    • DOI: 10.1016/j.foodchem.2026.148823

    1 Insight on

    • Increased Butyric Acid Production

    • Low evidence

  • Blueberry consumption enhances vascular function but not cognitive abilities in healthy individuals: a systematic review and meta-analysis.

    • 2026-05
    • Meta-Analysis · n = 632
    • Nutrition research (New York, N.Y.) 149
    • • Yu He
      • Jing Yang
      • Shuzhen Zhang
      • Junfan Mai
      • Meiying Li

    • PubMed: 41974068
    • DOI: 10.1016/j.nutres.2026.03.007

    5 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure
    • Improved Cognitive Function
    • Improved Mood
    • Improved Flow-Mediated Dilation

    • High evidence

  • Gegen Qinlian decoction alleviates bacterial diarrhea via Lactobacillus amylovorus-modulated restoration of colonic water transport through the cAMP/CFTR/AQP3 pathway.

    • 2026-05
    • Microbial pathogenesis 214
    • • Zhen-Ye Luo
      • Zhe Chen
      • Feng-Lin Zhang
      • Chang-Shun Liu
      • Fei-Long Chen
      • Ze-Zhong Zheng
      • Xiao-Mei Tan

    • PubMed: 41802655
    • DOI: 10.1016/j.micpath.2026.108434

    3 Insights on

    • Reduced Diarrhea Severity
    • Improved Water Absorption
    • Restored Colonic Water Transport

    • Low evidence
    • Animal Study

  • Effects of vitamin D supplementation on patients with systemic lupus erythematosus: A systematic review and meta-analysis.

    • 2026-05
    • Meta-Analysis · n = 847
    • Autoimmunity reviews 25(5)
    • • Jiale Lu
      • Qingmiao Zhu
      • Jiaxun Yu
      • Zhuchen Tan
      • Yingxin Kang
      • Qice Sun
      • Ting Zhao

    • PubMed: 41951148
    • DOI: 10.1016/j.autrev.2026.104057

    4 Insights on

    • Reduced Disease Activity
    • Improved Complement C3 Level
    • Improved Complement C4 Level
    • Reduced Anti-dsDNA Positivity

    • High evidence

  • Enhanced flavor and biogenic amine safety of salt-reduced Doubanjiang through co-inoculated fermentation with Pediococcus acidilactici and Zygosaccharomyces rouxii.

    • 2026-05
    • n = 226
    • Food research international (Ottawa, Ont.) 232
    • • Shenglan Liao
      • Youming Li
      • Jiayao Lin
      • Xiaoyi Wang
      • Yunhao Lu
      • Weiqin Deng
      • Qiang He
      • Yuanlong Chi
      • Zhenghong Xu

    • PubMed: 41895950
    • DOI: 10.1016/j.foodres.2026.118871

    1 Insight on

    • Improved Food Safety

    • Moderate evidence

  • Limosilactobacillus fermentum LF61: A multidimensional study on safety and functionality from genomics to clinical application.

    • 2026-05
    • RCT · n = 49
    • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 211
    • • Manfei Jin
      • Fei Xu
      • Yinhua Liu
      • Zhao Jiang

    • PubMed: 41655688
    • DOI: 10.1016/j.fct.2026.116002

    4 Insights on

    • Increased Immunoglobulin G Levels
    • Increased Immunoglobulin A Levels
    • Increased Immunoglobulin M Levels
    • Increased Antimicrobial Peptide LL-37 Level

    • High evidence

  • Structure-activity relationship of Laminaria japonica polysaccharide in promoting acetic acid synthesis by Lactobacillus rhamnosus GG.

    • 2026-05
    • Food research international (Ottawa, Ont.) 231
    • • Jiabin Wu
      • Yaqing Lin
      • Hangyu Huang
      • Lin Wang
      • Yi Zhang
      • Jin Wang
      • Lei Pan

    • PubMed: 41819923
    • DOI: 10.1016/j.foodres.2026.118756

    4 Insights on

    • Enhanced Probiotic Growth
    • Increased Lactobacillus rhamnosus Presence in Stool
    • Increased Acetic Acid Production
    • Increased Prebiotic Fermentation Activity

    • Low evidence

  • Chemo-immunotherapeutic potential of Lactobacillus rhamnosus GG and its bioengineering for cancer therapy.

    • 2026-05
    • Biomaterials 328
    • • Zhaonan Liu
      • Qing Guan
      • Jianfeng Xin
      • Wei Tang
      • Yu Chen
      • Jiaying Zhang
      • Junjie Chen
      • Shijie Bi
      • Peng Wang
      • Jun Liu

    • PubMed: 41237436
    • DOI: 10.1016/j.biomaterials.2025.123848

    2 Insights on

    • Increased Cell Death
    • Enhanced Antitumor Immune Response

    • Low evidence

  • Black tea consumption and the risk of coronary heart disease: a systematic review and meta-analysis of cohort studies.

    • 2026-05
    • Meta-Analysis · n = 477
    • Nutrition, metabolism, and cardiovascular diseases : NMCD 36(5)
    • • Ze-Mu Wang
      • Xiao-Qing Lian
      • Qingqing Long
      • Bo Wu
      • Lian-Sheng Wang

    • PubMed: 41152040
    • DOI: 10.1016/j.numecd.2025.104369

    1 Insight on

    • Reduced Risk of Coronary Heart Disease

    • High evidence

  • Effects of marine-derived Enterococcus durans YQ-6 on growth performance, intestinal health and microbial community of Leizhou black ducks.

    • 2026-05
    • RCT · n = 180
    • Poultry science 105(5)
    • • Yufeng Gou
      • Jiang Wu
      • Qiucheng Yao
      • Namula Zhao
      • Haiyan Wu
      • Zhibao Chen

    • PubMed: 41691807
    • DOI: 10.1016/j.psj.2026.106568

    2 Insights on

    • Improved Growth Performance
    • Improved Intestinal Health

    • High evidence

  • Vitamin C and postoperative outcomes following mandibular third molar extraction: a randomized split-mouth study.

    • 2026-05
    • RCT
    • Oral surgery, oral medicine, oral pathology and oral radiology 141(5)
    • • Merve Demirel
      • Alper Aktas
      • Mevlüde Kizil
      • Nadir Yalcin

    • PubMed: 41309404
    • DOI: 10.1016/j.oooo.2025.10.011

    2 Insights on

    • Reduced Pain
    • Reduced Facial Swelling

    • High evidence

  • Probiotic combinations affect characteristics of chickpea yogurt: an investigation on physicochemical, rheological, and organoleptic properties and SCFAs fermentation.

    • 2026-05
    • Food chemistry 510
    • • Haiyang Shi
      • Jing Luo
      • Zhexin Fan
      • Baokun Li
      • Xiaoqian Chen
      • Bingyuan Lei
      • Yingying Qiu
      • Jiancheng Wang
      • Tong Pan
      • Wenwei Lu
      • Zhifeng Fang

    • PubMed: 41795525
    • DOI: 10.1016/j.foodchem.2026.148756

    2 Insights on

    • Increased Short-Chain Fatty Acid Production
    • Improved Short-Chain Fatty Acid Production

    • Low evidence