November 2021 Supplement Research Papers

• November 2

  • Identification, Characterization, and Antioxidant Potential of Bifidobacterium longum subsp. longum Strains Isolated From Feces of Healthy Infants

    • 2021-11-02
    • Frontiers in Microbiology 12
    • • Li Zhao
      • Song Wang
      • Jiahuan Dong
      • Jialu Shi
      • Jiaqi Guan
      • Deyu Liu
      • Fei Liu
      • Bailiang Li
      • G. Huo

    • PubMed: 34795651
    • DOI: 10.3389/fmicb.2021.756519

    2 Insights on

    • Improved Antioxidant Capacity
    • Reduced Oxidative Stress

    • Low evidence

  • Lactobacillus rhamnosus LB1 Alleviates Enterotoxigenic Escherichia coli-Induced Adverse Effects in Piglets by Improving Host Immune Response and Anti-Oxidation Stress and Restoring Intestinal Integrity

    • 2021-11-02
    • RCT
    • Frontiers in Cellular and Infection Microbiology 11
    • • Tao Wu
      • Yutao Shi
      • Yanyan Zhang
      • Min Zhang
      • Lijuan Zhang
      • Zhi-xuan Ma
      • Di Zhao
      • Lei Wang
      • Hai Yu
      • Yongqing Hou
      • J. Gong

    • PubMed: 34796123
    • DOI: 10.3389/fcimb.2021.724401

    14 Insights on

    • Reduced Diarrhea Incidence
    • Improved Immune Function
    • Improved Immune Response
    • Reduced Hepatic Oxidative Stress
    • Reduced Diarrhea Rate
    • Reduced Colitis-Related Mortality
    • Improved Intestinal Barrier Integrity
    • Improved Blood Biochemical Indicators
    • Improved Antioxidant Capacity
    • Enhanced Intestinal Integrity
    • Reduced Mortality Rate
    • Reduced Pig Mortality
    • Enhanced Immune Capacity
    • Reduced Incidence of Diarrhea in Pigs

    • High evidence
• November 4

  • Insight Into the Beneficial Role of Lactiplantibacillus plantarum Supernatant Against Bacterial Infections, Oxidative Stress, and Wound Healing in A549 Cells and BALB/c Mice

    • 2021-11-04
    • Frontiers in Pharmacology 12
    • • A. Dubey
      • Mansi Podia
      • Priyanka
      • S. Raut
      • Sanpreet Singh
      • A. K. Pinnaka
      • Neeraj Khatri

    • PubMed: 34803678
    • DOI: 10.3389/fphar.2021.728614

    14 Insights on

    • Reduced Hepatic Oxidative Stress
    • Improved Wound Healing
    • Increased Antibacterial Activity
    • Accelerated Wound Healing
    • Increased Pro-inflammatory Cytokine IL-6
    • Protection Against Oxidative Stress
    • Improved Wound Healing in Infected Wounds
    • Increased IL-6 Levels in Early Phase
    • Improved Wound Healing In Vivo
    • Enhanced Wound Healing in Infections
    • Improved Histological Healing
    • Increased Pro-inflammatory Cytokines in Early Healing Phase
    • Enhanced Anti-inflammatory Cytokine Expression During Healing
    • Enhanced Safety in Topical Application

    • Low evidence

  • Effects of Clostridium butyricum and a Bacteriophage Cocktail on Growth Performance, Serum Biochemistry, Digestive Enzyme Activities, Intestinal Morphology, Immune Responses, and the Intestinal Microbiota in Rabbits

    • 2021-11-04
    • RCT
    • Antibiotics 10(11)
    • • Pan Huang
      • X. Cui
      • Zhipeng Wang
      • C. Xiao
      • Q. Ji
      • Q. Wei
      • Yee Huang
      • G. Bao
      • Yan Liu

    • PubMed: 34827285
    • DOI: 10.3390/antibiotics10111347

    4 Insights on

    • Improved Intestinal Morphology
    • Improved Growth Performance
    • Enhanced Digestive Enzyme Activity
    • Improved Antioxidant Capacity

    • High evidence

  • Unraveling the probiotic efficiency of bacterium Pediococcus pentosaceus OBK05 isolated from buttermilk: An in vitro study for cholesterol assimilation potential and antibiotic resistance status

    • 2021-11-04
    • PLOS ONE 16(11)
    • • Kiran Kumar Bhukya
      • Bhima Bhukya

    • PubMed: 34735552
    • DOI: 10.1371/journal.pone.0259702

    5 Insights on

    • Reduced Total Cholesterol Levels
    • Increased Antioxidant Activity
    • Reduced Pathogenic Bacteria
    • Improved Probiotic Potential
    • Reduced Nontransferable Antibiotic Resistance

    • Low evidence
    • Rigorous Journal
• November 6

  • Dietary Clostridium butyricum and Bacillus subtilis Promote Goose Growth by Improving Intestinal Structure and Function, Antioxidative Capacity and Microbial Composition

    • 2021-11-06
    • RCT
    • Animals 11(11)
    • • Jie Yu
      • Biao Dong
      • Minmeng Zhao
      • Long Liu
      • T. Geng
      • D. Gong
      • Jian Wang

    • PubMed: 34827906
    • DOI: 10.3390/ani11113174

    4 Insights on

    • Improved Intestinal Morphology
    • Increased Beneficial Gut Microbiota
    • Absence of Pathological Inflammation
    • Improved Antioxidative Capacity

    • High evidence
    • Rigorous Journal
• November 8

  • Bioprospecting Antimicrobials from Lactiplantibacillus plantarum: Key Factors Underlying Its Probiotic Action

    • 2021-11-08
    • Review
    • International Journal of Molecular Sciences 22(21)
    • • M. Rocchetti
      • P. Russo
      • V. Capozzi
      • D. Drider
      • G. Spano
      • D. Fiocco

    • PubMed: 34769500
    • DOI: 10.3390/ijms222112076

    3 Insights on

    • Improved Gut Health
    • Enhanced Antibacterial Effect
    • Improved Antiviral Effect

    • Low evidence

  • The Effects of L-Carnitine, Acetyl-L-Carnitine, and Propionyl-L-Carnitine on Body Mass in Type 2 Diabetes Mellitus Patients.

    • 2021-11-08
    • Systematic Review · n = 10
    • Frontiers in nutrition 8
    • • Dong-Dong Wang
      • Tian-Yun Wang
      • Yang Yang
      • Su-Mei He
      • You-Mei Wang

    • PubMed: 34820412
    • DOI: 10.3389/fnut.2021.748075

    1 Insight on

    • Reduced Body Mass Index

    • High evidence
• November 11

  • Clostridium butyricum Alleviates Enterotoxigenic Escherichia coli K88-Induced Oxidative Damage Through Regulating the p62-Keap1-Nrf2 Signaling Pathway and Remodeling the Cecal Microbial Community

    • 2021-11-11
    • Frontiers in Immunology 12
    • • Haihua Li
      • Zhiyuan Shang
      • Xuejiao Liu
      • Y. Qiao
      • Kewei Wang
      • J. Qiao

    • PubMed: 34899723
    • DOI: 10.3389/fimmu.2021.771826

    4 Insights on

    • Improved Intestinal Morphology
    • Improved Antioxidant Enzyme Levels
    • Reduced Oxidative Damage
    • Enhanced Gut Microbiota

    • Low evidence
• November 15

  • Microbiome therapeutics: exploring the present scenario and challenges.

    • 2021-11-15
    • Review
    • Gastroenterology report 10
    • • Monika Yadav
      • Nar Singh Chauhan

    • PubMed: 35382166
    • DOI: 10.1093/gastro/goab046

    3 Insights on

    • Reduced Abdominal Fat
    • Improved Sleep Quality
    • Reduced Fat Accumulation

    • Low evidence

  • The use of probiotics can reduce the severity of experimental periodontitis in rats with metabolic syndrome: an immunoenzymatic and microtomographic study.

    • 2021-11-15
    • RCT · n = 96
    • Journal of Periodontology 93(2)
    • • Giselle A Silva
      • A. L. Moreira
      • P. Silva
      • S. L. Salvador
      • R. Casarin
      • R. M. Vicente
      • Graziele C. Ferreira
      • J. E. dos Santos
      • F. Furlaneto
      • M. Messora

    • PubMed: 34374081
    • DOI: 10.1002/JPER.21-0285

    10 Insights on

    • Reduced Interleukin-6 Levels
    • Reduced Inflammation Levels
    • Reduced TNF-α Levels
    • Reduced Severity of Periodontitis
    • Reduced Interleukin-1β Levels
    • Reduced Alveolar Bone Resorption
    • Improved Immunoinflammatory Markers
    • Reduced Dyslipidemia in Metabolic Syndrome
    • Reduced RANKL/OPG Ratio
    • Reduced Dyslipidemia Parameters

    • Low evidence
    • Animal Study

  • Effects of probiotic Bifidobacterium bifidum G9‐1 on the gastrointestinal symptoms of patients with type 2 diabetes mellitus treated with metformin: An open‐label, single‐arm, exploratory research trial

    • 2021-11-15
    • Journal of Diabetes Investigation 13(3)
    • • Shinnosuke Hata
      • Hanako Nakajima
      • Y. Hashimoto
      • Tomoki Miyoshi
      • Yukako Hosomi
      • Takuro Okamura
      • Saori Majima
      • Naoko Nakanishi
      • Takafumi Sennmaru
      • T. Osaka
      • Hiroshi Okada
      • Emi Ushigome
      • M. Hamaguchi
      • M. Asano
      • M. Yamazaki
      • M. Fukui

    • PubMed: 34665938
    • DOI: 10.1111/jdi.13698

    6 Insights on

    • Reduced Constipation
    • Improved Gastrointestinal Symptoms
    • Reduced Diarrhea
    • Maintained Glucose Control
    • Reduced Relative Abundance of Sutterella
    • Improved Gastrointestinal Symptom Rating Scale Score

    • Low evidence
    • Rigorous Journal
• November 16

  • Efficacy of Bifidobacterium animalis subsp. lactis, BB-12® on infant colic - a randomised, double-blinded, placebo-controlled study.

    • 2021-11-16
    • RCT · n = 192
    • Beneficial Microbes 12(6)
    • • K. Chen
      • G. Zhang
      • H. Xie
      • L. You
      • H. Li
      • Y. Zhang
      • C. Du
      • S. Xu
      • C. Melsaether
      • S. Yuan

    • PubMed: 34550055
    • DOI: 10.3920/BM2020.0233

    8 Insights on

    • Reduced Inconsolable Crying Episodes
    • Increased Daily Sleep Duration
    • Increased Fecal Immunological Biomarkers
    • Increased Sleep Duration in Infants
    • Improved Immunological Biomarkers
    • Improved Parent/Caregiver Health-Related Quality of Life
    • Improved Sleep Duration
    • Improved Parent/Caregiver Quality of Life

    • High evidence

  • Protective effect of Lactiplantibacillus plantarum LP5 in a murine model of colonisation by Campylobacter coli DSPV458.

    • 2021-11-16
    • RCT
    • Beneficial Microbes 12(6)
    • • M. Ruiz
      • N. E. Sirini
      • M. Signorini
      • A. Etcheverría
      • M. V. Zbrun
      • L. Soto
      • J. Zimmermann
      • L. Frizzo

    • PubMed: 34590533
    • DOI: 10.3920/BM2021.0010

    3 Insights on

    • Improved Intestinal Function
    • Reduced Campylobacter Coli Colonization
    • Reduced Indigenous Enterobacteria Colonization

    • Low evidence
    • Animal Study
• November 17

  • Influence of Polysaccharides From Polygonatum kingianum on Short-Chain Fatty Acid Production and Quorum Sensing in Lactobacillus faecis.

    • 2021-11-17
    • Frontiers in microbiology 12
    • • Min Yang
      • Fanying Meng
      • Wen Gu
      • Lihui Fu
      • Fan Zhang
      • Fengjiao Li
      • Yating Tao
      • Zhengyang Zhang
      • Xi Wang
      • Xingxin Yang
      • Jingping Li
      • Jie Yu

    • PubMed: 34867887
    • DOI: 10.3389/fmicb.2021.758870

    3 Insights on

    • Increased Short-Chain Fatty Acid Production
    • Improved Gut Microbiome Function
    • Improved Quorum Sensing Signaling

    • Low evidence

  • Influence of Three Probiotics Strains, Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. Lactis BB-12 and Saccharomyces boulardii CNCM I-745 on the Biochemical and Haematological Profiles and Body Weight of Healthy Rabbits.

    • 2021-11-17
    • Biology 10(11)
    • • Louiza Kadja
      • Amira Leila Dib
      • Nedjoua Lakhdara
      • Assia Bouaziz
      • Elena Espigares
      • Mohammed Gagaoua

    • PubMed: 34827188
    • DOI: 10.3390/biology10111194

    3 Insights on

    • Improved Body Weight
    • Improved Biochemical Parameters
    • Improved Hematological Parameters

    • Low evidence

  • Short-term intake of Lactiplantibacillus plantarum ZDY2013 fermented milk promotes homoeostasis of gut microbiota under enterotoxigenic Bacillus cereus challenge.

    • 2021-11-17
    • Clinical Trial
    • Food & Function 12(11)
    • • Zhihong Zhang
      • M. Jin
      • Kaiming Wang
      • Na Zhang
      • Qimeng Zhang
      • X. Tao
      • Hua Wei

    • PubMed: 33973610
    • DOI: 10.1039/d1fo00162k

    13 Insights on

    • Reduced Body Weight
    • Preserved Gastrointestinal Histological Structure
    • Reduced Platelet Counts
    • Reduced Uric Acid Levels
    • Restored Gut Microbiota Diversity
    • Improved Gut Microbiota Balance
    • Reduced Weight Loss
    • Normalized Serum IL-1β Levels
    • Normalized Serum IL-10 Levels
    • Restored Gut Microbiome Balance
    • Restored Intestinal Structure
    • Improved Intestinal Structure
    • Reduced Gastrointestinal Tract Histological Damage

    • Low evidence
    • Animal Study
• November 18

  • Systematic Review and Meta-Analysis of L-Methylfolate Augmentation in Depressive Disorders.

    • 2021-11-18
    • Meta-Analysis · n = 707
    • Pharmacopsychiatry 55(03)
    • • Abdullah Al Maruf
      • Ethan A Poweleit
      • Lisa C Brown
      • Jeffrey R Strawn
      • Chad A Bousman

    • PubMed: 34794190
    • DOI: 10.1055/a-1681-2047

    2 Insights on

    • Reduced Depression Symptoms
    • Improved Antidepressant Response

    • High evidence
• November 19

  • High-quality whole-genome sequence analysis of Lactobacillus paragasseri UBLG-36 reveals oxalate-degrading potential of the strain

    • 2021-11-19
    • PLOS ONE 16(11)
    • • Yogita Mehra
      • P. Viswanathan

    • PubMed: 34797858
    • DOI: 10.1371/journal.pone.0260116

    1 Insight on

    • Enhanced Oxalate Degradation

    • Low evidence
    • Rigorous Journal
• November 22

  • Effects of Dietary Probiotic (Bacillus subtilis) Supplementation on Carcass Traits, Meat Quality, Amino Acid, and Fatty Acid Profile of Broiler Chickens

    • 2021-11-22
    • Frontiers in Veterinary Science 8
    • • Xiaopeng Tang
      • Xuguang Liu
      • Hu Liu

    • PubMed: 34881321
    • DOI: 10.3389/fvets.2021.767802

    8 Insights on

    • Reduced Abdominal Fat
    • Increased Muscle Mass
    • Improved Lipid Profile
    • Improved Carcass Characteristics
    • Improved Amino Acid Composition
    • Improved Milk Fatty Acid Profile
    • Improved Fatty Acid Profile
    • Improved Amino Acid Profile

    • Low evidence

  • Effects of Bacillus amyloliquefaciens LFB112 on Growth Performance, Carcass Traits, Immune, and Serum Biochemical Response in Broiler Chickens

    • 2021-11-22
    • RCT · n = 396
    • Antibiotics 10(11)
    • • Marhaba Ahmat
      • Junhao Cheng
      • Z. Abbas
      • Qiang Cheng
      • Zhen Fan
      • Baseer Ahmad
      • Min Hou
      • G. Osman
      • Henan Guo
      • Junyong Wang
      • Rijun Zhang

    • PubMed: 34827365
    • DOI: 10.3390/antibiotics10111427

    3 Insights on

    • Improved Immune Response
    • Improved Growth Performance
    • Improved Biochemical Parameters

    • Low evidence
    • Animal Study
• November 23

  • Different effects of soybean protein and its derived peptides on the growth and metabolism of Bifidobacterium animalis subsp. animalis JCM 1190.

    • 2021-11-23
    • Food & Function 12(13)
    • • Wenhui Li
      • He Li
      • Yinxiao Zhang
      • Lijuan He
      • Chi Zhang
      • Xinqi Liu

    • PubMed: 34132282
    • DOI: 10.1039/d1fo00480h

    1 Insight on

    • Enhanced Competitive Ability in Co-culture

    • Low evidence

  • Evaluating the effect of black myrobalan on cognitive, positive, and negative symptoms in patients with chronic schizophrenia: A randomized, double-blind, placebo-controlled trial.

    • 2021-11-23
    • RCT
    • Phytotherapy research : PTR 36(1)
    • • Mohammad Banazadeh
      • Mitra Mehrabani
      • Nabi Banazadeh
      • Fatemeh Dabaghzadeh
      • Farzad Shahabi

    • PubMed: 34814232
    • DOI: 10.1002/ptr.7340

    5 Insights on

    • Reduced Hyperactivity
    • Reduced Cognitive Impairment
    • Reduced Depressive Symptom
    • Reduced Negative Symptoms
    • Reduced Positive Symptom

    • High evidence

  • Effect of Tempeh on Gut Microbiota and Anti-Stress Activity in Zebrafish

    • 2021-11-23
    • RCT
    • International Journal of Molecular Sciences 22(23)
    • • Yo-Chia Chen
      • Nha-Linh Tao
      • Shao-Yang Hu
      • Hui-Yun Tsai
      • Sin-Chung Liao
      • W. Tsai
      • Chun-Yi Hu

    • PubMed: 34884465
    • DOI: 10.3390/ijms222312660

    7 Insights on

    • Increased Serum BDNF Levels
    • Improved Stress Management
    • Increased Levels of Actinobacteria
    • Reduced Cortisol Levels
    • Increased Exploratory Behavior
    • Reduced Gut Proteobacteria
    • Increased Bifidobacterium adolescentis Levels

    • Low evidence
    • Animal Study
• November 24

  • Genomic Stability and Phenotypic Characteristics of Industrially Produced Lacticaseibacillus rhamnosus GG in a Yogurt Matrix

    • 2021-11-24
    • Applied and Environmental Microbiology 87(24)
    • • Marianne Stage Strickertsson
      • Yan Hui
      • D. Nielsen
      • N. Vera-Jiménez
      • J. Olsen
      • A. Sandelin
      • Anita Wichmann

    • PubMed: 34613788
    • DOI: 10.1128/AEM.01575-21

    2 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Cytokine Secretion in Dendritic Cells

    • Low evidence
• November 25

  • Development of Anti-inflammatory Probiotic Limosilactobacillus reuteri EFEL6901 as Kimchi Starter: in vitro and In vivo Evidence.

    • 2021-11-25
    • Frontiers in microbiology 12
    • • Hee Seo
      • Hyunbin Seong
      • Ga Yun Kim
      • Yu Mi Jo
      • Seong Won Cheon
      • Youngju Song
      • Byung Hee Ryu
      • Hee Kang
      • Nam Soo Han

    • PubMed: 34899643
    • DOI: 10.3389/fmicb.2021.760476

    3 Insights on

    • Increased Short-Chain Fatty Acid Production
    • Reduced Inflammation
    • Improved Gut Barrier Function

    • Low evidence
• November 26

  • Pediococcus pentosaceus Enhances Host Resistance Against Pathogen by Increasing IL-1β Production: Understanding Probiotic Effectiveness and Administration Duration

    • 2021-11-26
    • Clinical Trial
    • Frontiers in Immunology 12
    • • Chengjie Shan
      • Miao Li
      • Zhuo Liu
      • Rong Xu
      • Fang Qiao
      • Z. Du
      • Meiling Zhang

    • PubMed: 34899717
    • DOI: 10.3389/fimmu.2021.766401

    3 Insights on

    • Increased Pathogen Resistance
    • Increased Interleukin-1 Beta Production
    • Increased Intestinal Neutrophil Levels

    • Low evidence
    • Animal Study
• November 27

  • Shatavari Supplementation in Postmenopausal Women Improves Handgrip Strength and Increases Vastus lateralis Myosin Regulatory Light Chain Phosphorylation but Does Not Alter Markers of Bone Turnover.

    • 2021-11-27
    • RCT
    • Nutrients 13(12)
    • • Mary F O'Leary
      • Sarah R Jackman
      • Vlad R Sabou
      • Matthew I Campbell
      • Jonathan C Y Tang
      • John Dutton
      • Joanna L Bowtell

    • PubMed: 34959836
    • DOI: 10.3390/nu13124282

    4 Insights on

    • Improved Handgrip Strength
    • Improved Knee Extensor Strength
    • Reduced P1NP Level
    • Reduced Beta-CrossLap

    • High evidence
    • Rigorous Journal

  • Lactobacillus delbrueckii CRL 581 Differentially Modulates TLR3-Triggered Antiviral Innate Immune Response in Intestinal Epithelial Cells and Macrophages.

    • 2021-11-27
    • Microorganisms 9(12)
    • • Mariano Elean
      • Leonardo Albarracin
      • Kohtaro Fukuyama
      • Binghui Zhou
      • Mikado Tomokiyo
      • Shugo Kitahara
      • Shota Araki
      • Yoshihito Suda
      • Lucila Saavedra
      • Julio Villena
      • Elvira M Hebert
      • Haruki Kitazawa

    • PubMed: 34946051
    • DOI: 10.3390/microorganisms9122449

    1 Insight on

    • Enhanced Antiviral Response

    • Low evidence
• November 28

  • Recent Progress in Applicability of Exercise Immunology and Inflammation Research to Sports Nutrition.

    • 2021-11-28
    • Review
    • Nutrients 13(12)
    • • Katsuhiko Suzuki

    • PubMed: 34959851
    • DOI: 10.3390/nu13124299

    2 Insights on

    • Reduced Inflammation
    • Reduced Oxidative Stress

    • Moderate evidence
    • Rigorous Journal
• November 29

  • Bifidobacterium longum Ameliorates Dextran Sulfate Sodium-Induced Colitis by Producing Conjugated Linoleic Acid, Protecting Intestinal Mechanical Barrier, Restoring Unbalanced Gut Microbiota, and Regulating the Toll-Like Receptor-4/Nuclear Factor-κB Signaling Pathway.

    • 2021-11-29
    • Clinical Trial
    • Journal of Agricultural and Food Chemistry 69(48)
    • • Yang Chen
      • Haiqin Chen
      • Jiuhong Ding
      • C. Stanton
      • R. Ross
      • Jianxin Zhao
      • Hao Zhang
      • Bo Yang
      • Wei Chen

    • PubMed: 34843239
    • DOI: 10.1021/acs.jafc.1c06176

    8 Insights on

    • Improved Intestinal Barrier Function
    • Increased Anti-Inflammatory Cytokine Levels
    • Reduced Pro-Inflammatory Cytokines
    • Reduced Inflammatory Response
    • Reduced Colitis Symptoms
    • Improved Gut Microbiota Balance
    • Restored Gut Microbiome Balance
    • Increased Colonic Conjugated Linoleic Acid Concentrations

    • Low evidence
    • Animal Study

  • Effects of Dietary Supplementation With Bacillus subtilis, as an Alternative to Antibiotics, on Growth Performance, Serum Immunity, and Intestinal Health in Broiler Chickens

    • 2021-11-29
    • RCT
    • Frontiers in Nutrition 8
    • • Kai Qiu
      • Cheng-liang Li
      • Jing Wang
      • G. Qi
      • Jun Gao
      • Haijun Zhang
      • Shu-geng Wu

    • PubMed: 34917643
    • DOI: 10.3389/fnut.2021.786878

    23 Insights on

    • Improved Intestinal Barrier Function
    • Increased Short-Chain Fatty Acid Levels
    • Improved Intestinal Morphology
    • Improved Immune Response
    • Reduced Colitis-Related Mortality
    • Improved Intestinal Function
    • Improved Average Daily Gain
    • Improved Growth Performance
    • Increased Beneficial Gut Microbiota
    • Increased Short-Chain Fatty Acid Production
    • Improved Gut Microbiota Balance
    • Reduced Harmful Gut Bacteria
    • Increased Short Chain Fatty Acids
    • Reduced Harmful Microorganisms
    • Reduced Mortality Rate
    • Improved Gut Microflora
    • Increased Serum Immunoglobulins
    • Increased Serum Lysozyme Levels
    • Increased Thymus Weight
    • Enhanced Beneficial Gut Microbiota
    • Balanced Gut Microbiota
    • Elevated Serum Immunoglobulin Levels
    • Increased Serum Immunoglobulin Levels

    • High evidence
• November 30

  • Lactobacillus plantarum HAC01 ameliorates type 2 diabetes in high-fat diet and streptozotocin-induced diabetic mice in association with modulating the gut microbiota.

    • 2021-11-30
    • Clinical Trial
    • Food & Function 12(14)
    • • Young-Sil Lee
      • Daeyoung Lee
      • Gun-seok Park
      • S. Ko
      • Juyi Park
      • You-Kyung Lee
      • Jihee Kang

    • PubMed: 34105563
    • DOI: 10.1039/d1fo00698c

    7 Insights on

    • Improved Insulin Sensitivity
    • Improved Blood Glucose Levels
    • Improved Glucose Tolerance
    • Increased Short Chain Fatty Acids
    • Increased β-Cell Area in Pancreatic Islets
    • Reduced Gluconeogenesis
    • Increased Glucose Metabolism Activation

    • Low evidence
    • Animal Study

  • Pediococcus pentosaceus IM96 Exerts Protective Effects against Enterohemorrhagic Escherichia coli O157:H7 Infection In Vivo

    • 2021-11-30
    • Clinical Trial
    • Foods 10(12)
    • • Haixin Li
      • Xinqiang Xie
      • Ying Li
      • Moutong Chen
      • L. Xue
      • Juan Wang
      • Jumei Zhang
      • Shi Wu
      • Qinghua Ye
      • Shuhong Zhang
      • Runshi Yang
      • Huiting Zhao
      • Lei Wu
      • Tingting Liang
      • Yu Ding
      • Qingping Wu

    • PubMed: 34945495
    • DOI: 10.3390/foods10122945

    11 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Inflammatory Response
    • Reduced Inflammatory Markers
    • Increased Tight Junction Protein Levels
    • Increased Anti-Inflammatory Levels
    • Alleviated Intestinal Damage
    • Regulated Intestinal Microbiota
    • Improved Intestinal Mucosal Health
    • Increased MUC-2 Levels
    • Elevated Short Chain Fatty Acids (SCFAs) Levels
    • Modulated Intestinal Microbial Community

    • Low evidence
    • Rigorous Journal
    • Animal Study
• Undated – 5 supplement studies

  • Treatment with a spore-based probiotic containing five strains of Bacillus induced changes in the metabolic activity and community composition of the gut microbiota in a SHIME® model of the human gastrointestinal system.

    • 2021-11
    • Food Research International 149
    • • M. Marzorati
      • P. van den Abbeele
      • Sarah S Bubeck
      • Thomas Bayne
      • K. Krishnan
      • Aicacia Young

    • PubMed: 34600678
    • DOI: 10.1016/j.foodres.2021.110676

    5 Insights on

    • Increased Short-Chain Fatty Acid Production
    • Reduced Lactate Levels
    • Improved Gut Bacterial Diversity
    • Reduced Ammonium Levels
    • Altered Microbial Population Composition

    • Low evidence

  • Lactobacillus johnsonii Attenuates Citrobacter rodentium-Induced Colitis by Regulating Inflammatory Responses and Endoplasmic Reticulum Stress in Mice.

    • 2021-11
    • RCT · n = 36
    • The Journal of Nutrition 151(11)
    • • Yunchang Zhang
      • Tianqi Mu
      • Ying Yang
      • Jinhua Zhang
      • F. Ren
      • Zhenlong Wu

    • PubMed: 34383918
    • DOI: 10.1093/jn/nxab250

    10 Insights on

    • Reduced Pro-Inflammatory Cytokines
    • Reduced Apoptosis of Jejunal Mucosal Cells
    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Organ Weight
    • Reduced Mucosal Thickness
    • Increased Colon Length
    • Reduced Immune Cell Infiltration
    • Reduced Colon Length
    • Reduced Spleen Weight Increase
    • Reduced Endoplasmic Reticulum Stress Markers

    • Low evidence
    • Animal Study

  • Oral administration of Lactobacillus crispatusM247 to papillomavirus-infected women: results of a preliminary, uncontrolled, open trial.

    • 2021-11
    • Clinical Trial · n = 35
    • Minerva Obstetrics and Gynecology 73(5)
    • • F. Di Pierro
      • A. Criscuolo
      • Anna Dei Giudici
      • R. Senatori
      • F. Sesti
      • M. Ciotti
      • E. Piccione

    • PubMed: 33876901
    • DOI: 10.23736/S2724-606X.21.04752-7

    3 Insights on

    • Improved Vaginal Microbiota Balance
    • Reduced HPV Positivity
    • Improved CST Status to CST I

    • High evidence

  • In vivo antimalarial activity of a probiotic bacterium Lactobacillus sakei isolated from traditionally fermented milk in BALB/c mice infected with Plasmodium berghei ANKA.

    • 2021-11
    • Journal of Ethnopharmacology 280
    • • Liliane Laure Toukam
      • Bertrand Tatsinkou Fossi
      • G. S. Taiwé
      • Raymond Bess Bila
      • David Denis Feugaing Sofeu
      • Enyong Peter Ivo
      • E. Achidi

    • PubMed: 34303805
    • DOI: 10.1016/j.jep.2021.114448

    4 Insights on

    • Maintained Body Weight
    • Inhibited Parasite Growth
    • Reduced Body Temperature
    • Prevention of Haematological Parameter Decline

    • Low evidence

  • Beta-alanine fails to improve on 5000 m running time despite increasing PAT1 expression in long-distance runners.

    • 2021-11
    • RCT · n = 16
    • The Journal of sports medicine and physical fitness 61(12)
    • • Gabriel S Franco
      • Natália Y Noronha
      • Bruno A Oliveira
      • Flávia C Ferreira
      • Ana P Pinto
      • Camila F Brandao
      • Marcelo Papoti
      • Carla B Nonino

    • PubMed: 33305552
    • DOI: 10.23736/s0022-4707.20.11946-7

    1 Insight on

    • Improved 5000 m Running Time

    • High evidence