December 2021 Supplement Research Papers

• December 1

  • Effectiveness of Inhaled Aromatherapy on Chemotherapy-Induced Nausea and Vomiting: A Systematic Review.

    • 2021-12-01
    • Systematic Review
    • Journal of alternative and complementary medicine (New York, N.Y.) 27(12)
    • • Jean Toniolo
      • Valérie Delaide
      • Pascale Beloni

    • PubMed: 34283916
    • DOI: 10.1089/acm.2021.0067

    1 Insight on

    • Reduced Nausea

    • High evidence

  • Lacticaseibacillus casei Strain T21 Attenuates Clostridioides difficile Infection in a Murine Model Through Reduction of Inflammation and Gut Dysbiosis With Decreased Toxin Lethality and Enhanced Mucin Production

    • 2021-12-01
    • Frontiers in Microbiology 12
    • • Wimonrat Panpetch
      • Pornpimol Phuengmaung
      • Thanya Cheibchalard
      • N. Somboonna
      • A. Leelahavanichkul
      • S. Tumwasorn

    • PubMed: 34925261
    • DOI: 10.3389/fmicb.2021.745299

    15 Insights on

    • Reduced Intestinal Permeability
    • Reduced Dysbiosis
    • Reduced Body Weight Loss
    • Increased Mucin Production
    • Reduced Intestinal Pathology
    • Improved Intestinal Cell Integrity
    • Reduced Expression of Lethal Toxin Genes
    • Reduced Gut Leakage
    • Reduced Hospital Mortality Rate
    • Reduced Pro-inflammatory Cytokine Levels
    • Improved Gut Integrity
    • Reduced Diarrhea Incidence
    • Reduced Diarrhea
    • Reduced Intestinal Pathology Changes
    • Reduced Pro-inflammatory Cytokine Release

    • Low evidence
• December 2

  • Lactobacillus rhamnosus strain LRH05 intervention ameliorated body weight gain and adipose inflammation via modulating the gut microbiota in high-fat diet-induced obese mice.

    • 2021-12-02
    • Clinical Trial · n = 8
    • Molecular Nutrition & Food Research 66(1)
    • • Yung-Tsung Chen
      • Shiou-Yun Chiou
      • Ai-Hua Hsu
      • Yu-Chun Lin
      • Jin-Seng Lin

    • PubMed: 34796638
    • DOI: 10.1002/mnfr.202100348

    4 Insights on

    • Reduced Macrophage Infiltration in Adipose Tissue
    • Improved Glucose Tolerance
    • Reduced Body Weight
    • Improved Liver Steatosis

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • In vitro assessment of histamine and lactate production by a multi-strain synbiotic.

    • 2021-12-02
    • Journal of food science and technology 59(9)
    • • Gerrit Stuivenberg
      • Brendan Daisley
      • Polycronis Akouris
      • Gregor Reid

    • PubMed: 35875231
    • DOI: 10.1007/s13197-021-05327-7

    2 Insights on

    • Comparable D-Lactate Production
    • Reduced D-Lactate Production

    • Low evidence
• December 3

  • Effect of Acute and Chronic Oral l-Carnitine Supplementation on Exercise Performance Based on the Exercise Intensity: A Systematic Review.

    • 2021-12-03
    • Systematic Review
    • Nutrients 13(12)
    • • Juan Mielgo-Ayuso
      • Laura Pietrantonio
      • Aitor Viribay
      • Julio Calleja-González
      • Jerónimo González-Bernal
      • Diego Fernández-Lázaro

    • PubMed: 34959912
    • DOI: 10.3390/nu13124359

    7 Insights on

    • Improved Work Capacity
    • Improved Leg Press Repetition Count
    • Reduced Rating of Perceived Exertion
    • Improved Peak Power
    • Improved Leg Press Volume
    • Improved Exercise Performance
    • Improved Power Output

    • High evidence
    • Rigorous Journal
• December 6

  • Antioxidative and Anti-Inflammatory Effects of Lactobacillus plantarum ZS62 on Alcohol-Induced Subacute Hepatic Damage

    • 2021-12-06
    • Clinical Trial
    • Oxidative Medicine and Cellular Longevity 2021
    • • Y. Gan
      • Xiufeng Chen
      • Ruokun Yi
      • Xin Zhao

    • PubMed: 34912498
    • DOI: 10.1155/2021/7337988

    5 Insights on

    • Reduced Liver Damage Indicators
    • Improved Total Antioxidant Status
    • Effectiveness Compared to Commercial Probiotic
    • Improved Lipid Metabolism
    • Reduced Inflammation Levels

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Microorganisms as Shapers of Human Civilization, from Pandemics to Even Our Genomes: Villains or Friends? A Historical Approach.

    • 2021-12-06
    • Review
    • Microorganisms 9(12)
    • • Francisco Rodríguez-Frías
      • Josep Quer
      • David Tabernero
      • Maria Francesca Cortese
      • Selene Garcia-Garcia
      • Ariadna Rando-Segura
      • Tomas Pumarola

    • PubMed: 34946123
    • DOI: 10.3390/microorganisms9122518

    1 Insight on

    • Improved Gastrointestinal Symptoms

    • Low evidence

  • Lactobacillus paracasei M11-4 isolated from fermented rice demonstrates good antioxidant properties in vitro and in vivo.

    • 2021-12-06
    • Journal of the Science of Food and Agriculture 102(8)
    • • Jianjun Yang
      • Chenyang Dong
      • F. Ren
      • Yuanhong Xie
      • Hui Liu
      • Hongxing Zhang
      • Junhua Jin

    • PubMed: 34786708
    • DOI: 10.1002/jsfa.11652

    9 Insights on

    • Improved Intestinal Microbiota
    • Modulated Gut Microbiota
    • Stabilized Intestinal Microbiota
    • Maintained Intestinal Microbiota Balance
    • Enhanced Antioxidant Enzyme Activity
    • Reduced Liver Damage
    • Reduced Oxidative Damage
    • Reduced Oxidative Damage in Serum
    • Maintained Intestinal Microbiota Stability

    • Low evidence
    • Rigorous Journal
• December 8

  • Herbal Products Used in Menopause and for Gynecological Disorders.

    • 2021-12-08
    • Review
    • Molecules (Basel, Switzerland) 26(24)
    • • Maša Kenda
      • Nina Kočevar Glavač
      • Milan Nagy
      • Marija Sollner Dolenc
      • On Behalf Of The Oemonom

    • PubMed: 34946512
    • DOI: 10.3390/molecules26247421

    1 Insight on

    • Reduced Menopausal Symptoms

    • Low evidence

  • Effects of Clostridium butyricum on Growth Performance, Gut Microbiota and Intestinal Barrier Function of Broilers

    • 2021-12-08
    • RCT
    • Frontiers in Microbiology 12
    • • Wenjia Li
      • Bin Xu
      • Linyi Wang
      • Quanyou Sun
      • W. Deng
      • F. Wei
      • Huihui Ma
      • Chen Fu
      • Gaili Wang
      • Shaoyu Li

    • PubMed: 34956140
    • DOI: 10.3389/fmicb.2021.777456

    6 Insights on

    • Enhanced Antioxidant Activity
    • Enhanced Immune Response
    • Improved Intestinal Barrier Function
    • Improved Growth Performance
    • Improved Gut Microbiota Diversity
    • Reduced Inflammation Levels

    • High evidence

  • Multi-Strain Probiotic Supplementation with a Product Containing Human-Native S. salivarius K12 in Healthy Adults Increases Oral S. salivarius

    • 2021-12-08
    • RCT · n = 25
    • Nutrients 13(12)
    • • Karina Cernioglo
      • K. Kalanetra
      • Anna K. Meier
      • Zachery T Lewis
      • M. Underwood
      • D. Mills
      • J. Smilowitz

    • PubMed: 34959944
    • DOI: 10.3390/nu13124392

    2 Insights on

    • No Change in Oral Microbiome
    • Increased Salivary Streptococcus salivarius K12 Levels

    • High evidence
• December 9

  • Characterization of the Probiotic Potential of Lactic Acid Bacteria Isolated from Kimchi, Yogurt, and Baby Feces in Hong Kong and Their Performance in Soymilk Fermentation.

    • 2021-12-09
    • Microorganisms 9(12)
    • • Haicui Wu
      • Tim-Fat Shum
      • Jiachi Chiou

    • PubMed: 34946146
    • DOI: 10.3390/microorganisms9122544

    4 Insights on

    • Improved Gastrointestinal Health
    • Increased Antioxidant Capacity
    • Improved Probiotic Starter Performance
    • Increased Antioxidant Activity

    • Low evidence
• December 10

  • Bifidobacterium animalis subsp. lactis lkm512 attenuates obesity-associated inflammation and insulin resistance through the modification of gut microbiota in high-fat diet-induced obese mice.

    • 2021-12-10
    • Clinical Trial
    • Molecular Nutrition & Food Research 66(3)
    • • Lingyan Ma
      • Aqian Zheng
      • Liyang Ni
      • Lianxin Wu
      • Luting Hu
      • Yufeng Zhao
      • Z. Fu
      • Y. Ni

    • PubMed: 34847296
    • DOI: 10.1002/mnfr.202100639

    5 Insights on

    • Reduced Metabolic Endotoxemia
    • Improved Intestinal Barrier Function
    • Improved Insulin Sensitivity
    • Reduced Inflammation
    • Reduced Liver Lipid Accumulation

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Effect of Lactobacillus rhamnosus MN-431 producing indole derivatives on complementary feeding-induced diarrhea rat pups through the enhancement of the intestinal barrier function.

    • 2021-12-10
    • Clinical Trial
    • Molecular Nutrition & Food Research 66(2)
    • • Haiyue Niu
      • Xiaohong Zhou
      • P. Gong
      • Y. Jiao
      • Jiliang Zhang
      • Yifan Wu
      • L. Lyu
      • Cong Liang
      • Shiwei Chen
      • Xue Han
      • Lanwei Zhang

    • PubMed: 34806832
    • DOI: 10.1002/mnfr.202100619

    3 Insights on

    • Reduced Mucosal Damage
    • Reduced Diarrhea Incidence
    • Improved Intestinal Barrier Function

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Efficacy of Lycium barbarum L. on plasma lipid concentration in adults: A protocol for systematic review and meta-analysis.

    • 2021-12-10
    • Systematic Review
    • Medicine 100(49)
    • • Xueyuan Zeng
      • Weimin Zhao
      • Yunlong Xu
      • Chengwei Zhang
      • Junliang Wu
      • Libo Xia
      • Ziyue Tian
      • Jixiang Ren

    • PubMed: 34889292
    • DOI: 10.1097/md.0000000000028172

    4 Insights on

    • Reduced Blood Cholesterol
    • Reduced LDL Cholesterol
    • Reduced Triglyceride Levels
    • Increased High-Density Lipoprotein Cholesterol

    • High evidence
• December 11

  • In Vitro and In Vivo Digestion of Persimmon and Derived Products: A Review.

    • 2021-12-11
    • Review
    • Foods (Basel, Switzerland) 10(12)
    • • Cristina M González
      • Isabel Hernando
      • Gemma Moraga

    • PubMed: 34945634
    • DOI: 10.3390/foods10123083

    2 Insights on

    • Reduced Hyperlipidemia
    • Reduced Hyperglycemic Response

    • Low evidence
• December 13

  • A Pilot, Phase II, Observational, Case-Control, 1-Month Study on Asthenopia in Video Terminal Operators without Dry Eye: Contrast Sensitivity and Quality of Life before and after the Oral Consumption of a Fixed Combination of Zinc, L-Carnitine, Extract of Elderberry, Currant and Extract of Eleutherococcus.

    • 2021-12-13
    • Observational · n = 30
    • Nutrients 13(12)
    • • Gemma Caterina Maria Rossi
      • Luigia Scudeller
      • Federica Bettio
      • Giovanni Milano

    • PubMed: 34960000
    • DOI: 10.3390/nu13124449

    2 Insights on

    • Improved Contrast Sensitivity
    • Reduced Computer Vision Symptom Scale Score

    • High evidence
    • Rigorous Journal
• December 14

  • Bifidobacterium animalis subsp. lactis HN019 Effects on Gut Health: A Review

    • 2021-12-14
    • Review
    • Frontiers in Nutrition 8
    • • Jing Cheng
      • A. Laitila
      • A. Ouwehand

    • PubMed: 34970580
    • DOI: 10.3389/fnut.2021.790561

    9 Insights on

    • Improved Bowel Movement Frequency
    • Maintained Barrier Function
    • Increased Bowel Movement Frequency
    • Reduced Intestinal Transit Time
    • Reduced Diarrhea Incidence
    • Improved Intestinal Barrier Function
    • Supported Physiological Function in Elderly
    • Reduced Diarrhea Rate
    • Reduced Interleukin-6 Levels

    • Low evidence

  • Immunological Effects of Adding Bovine Lactoferrin and Reducing Iron in Infant Formula: A Randomized Controlled Trial.

    • 2021-12-14
    • RCT · n = 180
    • Journal of pediatric gastroenterology and nutrition 74(3)
    • • Maria Björmsjö
      • Olle Hernell
      • Bo Lönnerdal
      • Staffan K Berglund

    • PubMed: 34908015
    • DOI: 10.1097/mpg.0000000000003367

    6 Insights on

    • Reduced Respiratory Infection
    • Reduced Gastroenteritis
    • Reduced Interleukin-2 Level
    • Reduced Otitis
    • Reduced Tumor Necrosis Factor Alpha
    • Increased Transforming Growth Factor-β Levels

    • High evidence
    • Large Human Trial
• December 15

  • Concurrent Treatment with Vitamin K2 and D3 on Spine Fusion in Patients with Osteoporosis-Associated Lumbar Degenerative Disorders.

    • 2021-12-15
    • Clinical Trial
    • Spine 47(4)
    • • Wencan Zhang
      • Le Li
      • Xin Zhou
      • Kunpeng Li
      • Chen Liu
      • Xiangyu Lin
      • Njabulo Lubisi
      • Junfei Chen
      • Haipeng Si

    • PubMed: 34919073
    • DOI: 10.1097/brs.0000000000004309

    1 Insight on

    • Increased Spinal Fusion Rate

    • Moderate evidence
• December 16

  • Pediococcus pentosaceus: Screening and Application as Probiotics in Food Processing

    • 2021-12-16
    • Review
    • Frontiers in Microbiology 12
    • • Yining Qi
      • Le Huang
      • Yan Zeng
      • Wen Li
      • Diao Zhou
      • Jianhua Xie
      • Junyan Xie
      • Qiang Tu
      • Dun Deng
      • Jia Yin

    • PubMed: 34975787
    • DOI: 10.3389/fmicb.2021.762467

    3 Insights on

    • Increased Antioxidant Activity
    • Enhanced Immune Function
    • Reduced Total Cholesterol Levels

    • Low evidence
• December 17

  • Relationship between Structure and Biological Activity of Various Vitamin K Forms.

    • 2021-12-17
    • Review
    • Foods (Basel, Switzerland) 10(12)
    • • Katarzyna Bus
      • Arkadiusz Szterk

    • PubMed: 34945687
    • DOI: 10.3390/foods10123136

    2 Insights on

    • Improved Blood Coagulation
    • Inhibited Decline in Bone Mineral Density

    • Low evidence
• December 18

  • Prebiotics, Probiotics, Synbiotics, Paraprobiotics and Postbiotic Compounds in IBD.

    • 2021-12-18
    • Review
    • Biomolecules 11(12)
    • • Adrian Martyniak
      • Aleksandra Medyńska-Przęczek
      • Andrzej Wędrychowicz
      • Szymon Skoczeń
      • Przemysław J Tomasik

    • PubMed: 34944546
    • DOI: 10.3390/biom11121903

    3 Insights on

    • Reduced Inflammatory Bowel Disease Symptoms
    • Improved Gastrointestinal Inflammation
    • Modulated Gut Microbiota

    • Moderate evidence
    • Highly Cited
• December 20

  • Fat-Soluble Vitamin Supplementation Using Liposomes, Cyclodextrins, or Medium-Chain Triglycerides in Cystic Fibrosis: A Randomized Controlled Trial.

    • 2021-12-20
    • RCT
    • Nutrients 13(12)
    • • Jan K Nowak
      • Paulina Sobkowiak
      • Sławomira Drzymała-Czyż
      • Patrycja Krzyżanowska-Jankowska
      • Ewa Sapiejka
      • Wojciech Skorupa
      • Andrzej Pogorzelski
      • Agata Nowicka
      • Irena Wojsyk-Banaszak
      • Szymon Kurek
      • Barbara Zielińska-Psuja
      • Aleksandra Lisowska
      • Jarosław Walkowiak

    • PubMed: 34960106
    • DOI: 10.3390/nu13124554

    2 Insights on

    • Increased All-Trans-Retinol Level
    • Increased 25-hydroxyvitamin D Level

    • High evidence
    • Rigorous Journal
• December 21

  • Phenolics Profile, Antioxidant Activity and Flavor Volatiles of Pear Juice: Influence of Lactic Acid Fermentation Using Three Lactobacillus Strains in Monoculture and Binary Mixture.

    • 2021-12-21
    • Foods (Basel, Switzerland) 11(1)
    • • Leyu Wang
      • Hexin Zhang
      • Hongjie Lei

    • PubMed: 35010138
    • DOI: 10.3390/foods11010011

    2 Insights on

    • Improved Antioxidant Activity
    • Improved Phenolic Profile

    • Low evidence

  • An Update on the Effects of Probiotics on Gastrointestinal Cancers.

    • 2021-12-21
    • Review
    • Frontiers in pharmacology 12
    • • Amirhossein Davoodvandi
      • Farzaneh Fallahi
      • Omid Reza Tamtaji
      • Vida Tajiknia
      • Zarrin Banikazemi
      • Hadis Fathizadeh
      • Mohammad Abbasi-Kolli
      • Michael Aschner
      • Maryam Ghandali
      • Amirhossein Sahebkar
      • Mohsen Taghizadeh
      • Hamed Mirzaei

    • PubMed: 34992527
    • DOI: 10.3389/fphar.2021.680400

    1 Insight on

    • Reduced Inflammation

    • Low evidence

  • Neurocognitive Effects of Cocoa and Red-Berries Consumption in Healthy Adults.

    • 2021-12-21
    • RCT
    • Nutrients 14(1)
    • • Joaquín García-Cordero
      • Alicia Pino
      • Constanza Cuevas
      • Verónica Puertas-Martín
      • Ricardo San Román
      • Sonia de Pascual-Teresa

    • PubMed: 35010877
    • DOI: 10.3390/nu14010001

    4 Insights on

    • Reduced Tower of London Test Start Time
    • Increased Nerve Growth Factor Receptor Level
    • Reduced Tower of London Test Completion Time
    • Increased Brain-derived Neurotrophic Factor Level

    • High evidence
    • Rigorous Journal

  • Serenoa repens and its effects on male sexual function. A systematic review and meta-analysis of clinical trials.

    • 2021-12-21
    • Meta-Analysis
    • Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica 93(4)
    • • Gianni Paulis
      • Andrea Paulis
      • Gianpaolo Perletti

    • PubMed: 34933534
    • DOI: 10.4081/aiua.2021.4.475

    1 Insight on

    • Reduced Sexual Function

    • High evidence
• December 22

  • Recent Development of Probiotic Bifidobacteria for Treating Human Diseases

    • 2021-12-22
    • Review
    • Frontiers in Bioengineering and Biotechnology 9
    • • Jun Chen
      • Xinyi Chen
      • Chun Loong Ho

    • PubMed: 35004640
    • DOI: 10.3389/fbioe.2021.770248

    1 Insight on

    • Improved Gastrointestinal Health

    • Low evidence
• December 23

  • Lactobacillus rhamnosus attenuates Thai chili extracts induced gut inflammation and dysbiosis despite capsaicin bactericidal effect against the probiotics, a possible toxicity of high dose capsaicin

    • 2021-12-23
    • RCT
    • PLOS ONE 16(12)
    • • Wimonrat Panpetch
      • Peerapat Visitchanakun
      • Wilasinee Saisorn
      • A. Sawatpanich
      • Piraya Chatthanathon
      • N. Somboonna
      • S. Tumwasorn
      • A. Leelahavanichkul

    • PubMed: 34941893
    • DOI: 10.1371/journal.pone.0261189

    16 Insights on

    • Reduced Enterocyte Injury from Capsaicin
    • Reduced Enterocyte Damage
    • Attenuated Gut Dysbiosis
    • Improved Barrier Integrity
    • Reduced Gut Barrier Defect
    • Reduced Intestinal Permeability
    • Reduced Dysbiosis
    • Improved Capsaicin Tolerance
    • Improved Intestinal Barrier Function
    • Improved Gut Microbiota Balance
    • Reduced Inflammation
    • No Change in Fecal Abundance of L34 or LGG
    • Unchanged Stool Consistency
    • Attenuated Enterocyte Injury
    • Improved Gut Barrier Function
    • Reduced Gut Permeability

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Locked Nucleic Acid Hydrolysis Probes for the Specific Identification of Probiotic Strains Bifidobacterium animalis subsp. lactis DSM 15954 and Bi-07™

    • 2021-12-23
    • Frontiers in Microbiology 12
    • • H. Shehata
      • Anthony Kiefer
      • Wesley Morovic
      • S. Newmaster

    • PubMed: 35003031
    • DOI: 10.3389/fmicb.2021.801795

    1 Insight on

    • Strain Authentication and Identification

    • Low evidence
• December 26

  • Propionyl-L-carnitine for intermittent claudication.

    • 2021-12-26
    • Meta-Analysis · n = 1,395
    • The Cochrane database of systematic reviews 2021(12)
    • • Victor Kamoen
      • Robert Vander Stichele
      • Laurence Campens
      • Dirk De Bacquer
      • Luc Van Bortel
      • Tine Lm de Backer

    • PubMed: 34954832
    • DOI: 10.1002/14651858.cd010117.pub2

    2 Insights on

    • Improved Maximal Walking Performance
    • Improved Pain-Free Walking Distance

    • High evidence
• December 29

  • The beneficial effects of Lactobacillus brevis FZU0713-fermented Laminaria japonica on lipid metabolism and intestinal microbiota in hyperlipidemic rats fed with a high-fat diet.

    • 2021-12-29
    • Clinical Trial
    • Food & Function 12(16)
    • • Qing Zhang
      • Xiaoyun Fan
      • Ying-Jia Cao
      • T. Zheng
      • Wenjian Cheng
      • Lijiao Chen
      • Xu-Cong Lv
      • Li Ni
      • P. Rao
      • Peng Liang

    • PubMed: 34231612
    • DOI: 10.1039/d1fo00218j

    13 Insights on

    • Reduced Metabolic Function
    • Increased Short-Chain Fatty Acid Levels
    • Improved Intestinal Microbial Composition
    • Improved Microbiota Profile
    • Reduced Metabolic Functions of Intestinal Microbiota
    • Reduced Hepatic Lipid Accumulation
    • Increased SCFA Levels
    • Improved Biochemical Parameters
    • Increased Short Chain Fatty Acids
    • Reduced Obesity
    • Improved Abundance of Beneficial Bacteria
    • Improved Lipid Metabolism
    • Reduced Liver Lipid Accumulation

    • Low evidence
    • Animal Study
• December 30

  • Bifidobacterium adolescentis Alleviates Liver Steatosis and Steatohepatitis by Increasing Fibroblast Growth Factor 21 Sensitivity

    • 2021-12-30
    • Frontiers in Endocrinology 12
    • • Xiaoxue Long
      • Dan Liu
      • Qiongmei Gao
      • Jiacheng Ni
      • L. Qian
      • Y. Ni
      • Q. Fang
      • W. Jia
      • Huating Li

    • PubMed: 35035378
    • DOI: 10.3389/fendo.2021.773340

    4 Insights on

    • Improved FGF21 Sensitivity
    • Improved Gut Barrier Function
    • Improved Liver Steatosis
    • Reduced NAFLD Activity Score

    • Low evidence
• December 31

  • A double-blind, randomized controlled trial to examine the effect of Moringa oleifera leaf powder supplementation on the immune status and anthropometric parameters of adult HIV patients on antiretroviral therapy in a resource-limited setting.

    • 2021-12-31
    • RCT
    • PloS one 16(12)
    • • Aisha Gambo
      • Indres Moodley
      • Musa Babashani
      • Tesleem K Babalola
      • Nceba Gqaleni

    • PubMed: 34972169
    • DOI: 10.1371/journal.pone.0261935

    4 Insights on

    • Reduced Viral Load
    • Reduced Body Weight
    • Reduced Body Mass Index
    • Increased CD4+ T Cell Count

    • High evidence

  • Bifidobacterium bifidum Shows More Diversified Ways of Relieving Non-Alcoholic Fatty Liver Compared with Bifidobacterium adolescentis

    • 2021-12-31
    • Clinical Trial
    • Biomedicines 10(1)
    • • Linlin Wang
      • Ting Jiao
      • Q. Yu
      • Jialiang Wang
      • Luyao Wang
      • G. Wang
      • Hao Zhang
      • Jianxin Zhao
      • Wei Chen

    • PubMed: 35052765
    • DOI: 10.3390/biomedicines10010084

    10 Insights on

    • Improved Gut Permeability
    • Alleviated Non-Alcoholic Fatty Liver Disease
    • Reduced Liver Fat Accumulation
    • Improved Abundance of Beneficial Bacteria
    • Reduced Hepatic Fat Accumulation
    • Improved Lipid Metabolism
    • Reduced Liver Inflammation
    • Reduced Inflammation
    • Regulated Intestinal Microbiota
    • Increased Short-Chain Fatty Acid Levels

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Vitamin B1 Intake and the Risk of Colorectal Cancer: a Systematic Review of Observational Studies.

    • 2021-12-31
    • Meta-Analysis
    • Journal of nutritional science and vitaminology 67(6)
    • • Yan Liu
      • Wen-Jing Xiong
      • Lei Wang
      • Wei-Qing Rang
      • Chuanhua Yu

    • PubMed: 34980717
    • DOI: 10.3177/jnsv.67.391

    1 Insight on

    • Reduced Risk of Colorectal Cancer

    • High evidence

  • Evaluation of 2’-Fucosyllactose and Bifidobacterium longum Subspecies infantis on Growth, Organ Weights, and Intestinal Development of Piglets

    • 2021-12-31
    • RCT
    • Nutrients 14(1)
    • • V. Daniels
      • M. Monaco
      • Mei Wang
      • J. Hirvonen
      • H. Jensen
      • A. Ouwehand
      • R. Mukherjea
      • R. Dilger
      • S. Donovan

    • PubMed: 35011074
    • DOI: 10.3390/nu14010199

    1 Insight on

    • Reduced Crypt Depth

    • High evidence
• Undated – 19 supplement studies

  • Bacteriocins: Properties and potential use as antimicrobials.

    • 2021-12
    • Review
    • Journal of clinical laboratory analysis 36(1)
    • • Atieh Darbandi
      • Arezoo Asadi
      • Marzieh Mahdizade Ari
      • Elnaz Ohadi
      • Malihe Talebi
      • Masoume Halaj Zadeh
      • Amir Darb Emamie
      • Roya Ghanavati
      • Maryam Kakanj

    • PubMed: 34851542
    • DOI: 10.1002/jcla.24093

    1 Insight on

    • Reduced Foodborne Pathogens

    • Moderate evidence
    • Highly Cited

  • Probiotic properties of Lactobacillus casei – MYSRD 108 and Lactobacillus plantarum-MYSRD 71 with potential antimicrobial activity against Salmonella paratyphi

    • 2021-12
    • Biotechnology Reports 32
    • • S. Divyashree
      • P. Anjali
      • Rakesh Somashekaraiah
      • M. Sreenivasa

    • PubMed: 34540599
    • DOI: 10.1016/j.btre.2021.e00672

    1 Insight on

    • Reduced Salmonella Paratyphi Growth

    • Low evidence

  • Effect of food sources of nitrate, polyphenols, L-arginine and L-citrulline on endurance exercise performance: a systematic review and meta-analysis of randomised controlled trials.

    • 2021-12
    • Meta-Analysis
    • Journal of the International Society of Sports Nutrition 18(1)
    • • Noah M A d'Unienville
      • Henry T Blake
      • Alison M Coates
      • Alison M Hill
      • Alison M Hill
      • Maximillian J Nelson
      • Jonathan D Buckley

    • PubMed: 34965876
    • DOI: 10.1186/s12970-021-00472-y

    1 Insight on

    • Improved Endurance Exercise Performance

    • High evidence

  • The divergent roles of sortase in the biology of Gram-positive bacteria.

    • 2021-12
    • Review
    • Cell surface (Amsterdam, Netherlands) 7
    • • Aliyath Susmitha
      • Harsha Bajaj
      • Kesavan Madhavan Nampoothiri

    • PubMed: 34195501
    • DOI: 10.1016/j.tcsw.2021.100055

    2 Insights on

    • Improved Whole Gut Transit Time
    • Improved Immunomodulation

    • Low evidence

  • Efficacy of medicinal plant extracts as dental and periodontal antibiofilm agents: A systematic review of randomized clinical trials.

    • 2021-12
    • Systematic Review
    • Journal of ethnopharmacology 281
    • • Victoria Furquim Dos Santos Cardoso
      • Ricardo Haack Amaral Roppa
      • Carolina Antunes
      • Amanda Naiara Silva Moraes
      • Lucélia Santi
      • Eduardo Luis Konrath

    • PubMed: 34416298
    • DOI: 10.1016/j.jep.2021.114541

    2 Insights on

    • Reduced Gingival Index
    • Reduced Plaque Index

    • High evidence

  • Watermelon and L-Citrulline in Cardio-Metabolic Health: Review of the Evidence 2000-2020.

    • 2021-12
    • Review
    • Current atherosclerosis reports 23(12)
    • • Britt Burton-Freeman
      • Morganne Freeman
      • Xuhuiqun Zhang
      • Amandeep Sandhu
      • Indika Edirisinghe

    • PubMed: 34894302
    • DOI: 10.1007/s11883-021-00978-5

    1 Insight on

    • Reduced Blood Pressure

    • Low evidence

  • Antidiabetic effect of an engineered bacterium Lactobacillus plantarum-pMG36e -GLP-1 in monkey model

    • 2021-12
    • Clinical Trial
    • Synthetic and Systems Biotechnology 6(4)
    • • Jie Luo
      • Hongfei Zhang
      • Jiachen Lu
      • Chaolin Ma
      • Tingtao Chen

    • PubMed: 34584995
    • DOI: 10.1016/j.synbio.2021.09.009

    4 Insights on

    • Enhanced Metabolic Pathway Activation
    • Reduced Body Weight
    • Reduced Fasting Blood Sugar Levels
    • Reduced Intestinal Pathogen Prevotella

    • Low evidence
    • Animal Study

  • Evidence of Lactobacillus reuteri to reduce colic in breastfed babies: Systematic review and meta-analysis.

    • 2021-12
    • Meta-Analysis
    • Complementary Therapies in Medicine 63
    • • Angela Pierina Dos Reis Buzzo Zermiani
      • Ana Luiza Pelissari Peçanha de Paula Soares
      • Bárbara Leticia da Silva Guedes de Moura
      • Edson Roberto Arpini Miguel
      • Luciana Dias Ghiraldi Lopes
      • N. Santana
      • T. Da Silva Santos
      • I. G. Demarchi
      • Jorge Juarez Teixeira

    • PubMed: 34627993
    • DOI: 10.1016/j.ctim.2021.102781

    7 Insights on

    • Reduced Average Daily Crying Time by 50% or More
    • Reduced Crying Duration
    • Effective Colic Treatment
    • Improved Colic Treatment Effectiveness at Two to Three Weeks
    • Reduced Crying in Infants
    • Reduced Crying Time in Infants with Colic
    • Reduced Colic Symptoms

    • High evidence

  • The effects of Cuminum cyminum on glycemic parameters: A systematic review and meta-analysis of controlled clinical trials.

    • 2021-12
    • Meta-Analysis
    • Journal of ethnopharmacology 281
    • • Omid Mohammad Tavakoli-Rouzbehani
      • Amir Hossein Faghfouri
      • Maryam Anbari
      • Shahab Papi
      • Farid Salimi Shojaei
      • Mehdi Ghaffari
      • Mohammad Alizadeh

    • PubMed: 34371114
    • DOI: 10.1016/j.jep.2021.114510

    6 Insights on

    • Improved Beta-Cell Function
    • Reduced Hemoglobin A1c
    • Improved Insulin Sensitivity
    • Reduced Fasting Blood Glucose Levels
    • Improved Insulin Levels
    • Improved Insulin Resistance

    • High evidence

  • Beneficial effects of natural products on female sexual dysfunction: A systematic review and meta-analysis.

    • 2021-12
    • Meta-Analysis · n = 536
    • Phytomedicine : international journal of phytotherapy and phytopharmacology 93
    • • Nahdiya Sha'ari
      • Luke Sy-Cherng Woon
      • Hatta Sidi
      • Srijit Das
      • Chad A Bousman
      • Suriati Mohamed Saini

    • PubMed: 34638031
    • DOI: 10.1016/j.phymed.2021.153760

    4 Insights on

    • Improved Female Sexual Function
    • Improved Sexual Desire
    • Improved Sexual Orgasm
    • Improved Sexual Arousal

    • High evidence

  • Lactobacillus plantarum 23-1 improves intestinal inflammation and barrier function through the TLR4/NF-κB signaling pathway in obese mice.

    • 2022
    • Clinical Trial
    • Food & Function 13(11)
    • • Zhijing Liu
      • Jiale Zhao
      • Rongbo Sun
      • Min Wang
      • Kunyang Wang
      • Yanan Li
      • H. Shang
      • Juncai Hou
      • Zhan-mei Jiang

    • PubMed: 35546499
    • DOI: 10.1039/d1fo04316a

    9 Insights on

    • Reduced Histological Damage
    • Reduced Body Weight
    • Reduced Intestinal Inflammation
    • Improved Intestinal Barrier Function
    • Reduced Hepatic Oxidative Stress
    • Reduced Oxidative Stress
    • Improved Lipid Levels
    • Reduced Inflammatory Response
    • Reduced Histopathological Damage

    • Low evidence
    • Animal Study

  • Macronutrients, vitamins and minerals in the diet of multiple sclerosis patients.

    • 2022
    • Review
    • Postepy psychiatrii neurologii 31(3)
    • • Magdalena Zielińska
      • Izabela Michońska

    • PubMed: 37082222
    • DOI: 10.5114/ppn.2022.121730

    1 Insight on

    • Improved Multiple Sclerosis Course

    • Low evidence

  • Biomedical role of L-carnitine in several organ systems, cellular tissues, and COVID-19.

    • 2022
    • Review
    • Brazilian journal of biology = Revista brasleira de biologia 82
    • • I S Al-Dhuayan

    • PubMed: 36629544
    • DOI: 10.1590/1519-6984.267633

    4 Insights on

    • Reduced Neuropathic Pain
    • Reduced Blood Glucose Levels
    • Reduced Alzheimer Disease Symptom
    • Reduced Fatigue

    • Low evidence

  • Efficacy of Melaleuca alternifolia and chlorhexidine mouth rinses in reducing oral malodor and Solobacterium moorei levels. A 1 week, randomized, double-blind, parallel study.

    • 2022
    • RCT · n = 160
    • Indian journal of pharmacology 54(2)
    • • K Prabhu Srikumar
      • B N Bhagyashree
      • Sridharan Srirangarajan
      • Rao J Ravi
      • Rudresh Vinaya

    • PubMed: 35546457
    • DOI: 10.4103/ijp.ijp_772_20

    2 Insights on

    • Reduced Solobacterium moorei Level
    • Reduced Oral Malodor

    • High evidence
    • Large Human Trial

  • Alterations in infant gut microbiome composition and metabolism after exposure to glyphosate and Roundup and/or a spore-based formulation using the SHIME technology.

    • 2022
    • Gut microbiome (Cambridge, England) 3
    • • Robin Mesnage
      • Marta Calatayud
      • Cindy Duysburgh
      • Massimo Marzorati
      • Michael N Antoniou

    • PubMed: 39295780
    • DOI: 10.1017/gmb.2022.5

    7 Insights on

    • Increased Lactobacilli Abundance
    • Altered Short-Chain Fatty Acid Production
    • Increased Fecal Lactobacilli
    • Restored Short-Chain Fatty Acid Levels
    • Reversed Microbiome Metabolic Changes
    • Increased Protease Activity
    • Increased Short-Chain Fatty Acid Levels

    • Low evidence

  • Dietary Supplementation with Oyster Culinary-Medicinal Mushroom, Pleurotus ostreatus (Agaricomycetes), Reduces Visceral Fat and Hyperlipidemia in Inhabitants of a Rural Community in Mexico.

    • 2022
    • RCT · n = 30
    • International journal of medicinal mushrooms 24(9)
    • • Adrián González-Bonilla
      • María Eugenia Meneses
      • Aleyda Pérez-Herrera
      • David Armengol-Álvarez
      • Daniel Martínez-Carrera

    • PubMed: 36004709
    • DOI: 10.1615/intjmedmushrooms.2022044837

    4 Insights on

    • Reduced Visceral Fat
    • Reduced Blood Glucose Levels
    • Reduced Triglyceride Levels
    • Reduced Blood Cholesterol

    • High evidence

  • The role of probiotics in the immune response and intestinal microbiota of children with celiac disease: a systematic review.

    • 2022
    • Systematic Review
    • Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo 40
    • • Camila Fernanda Jedwab
      • Bruna Cardoso de Mattos Boccalini Roston
      • Ana Beatriz Ferreira de Souza Toge
      • Isadora Fagundes Echeverria
      • Guilherme Ojea Gomes Tavares
      • Matheus Alves Alvares
      • Vera Esteves Vagnozzi Rullo
      • Marcella Rocha Machado de Oliveira

    • PubMed: 34495279
    • DOI: 10.1590/1984-0462/2022/40/2020447

    2 Insights on

    • Restored Fecal Microbiota Abundance
    • Reduced Pro-inflammatory Cytokine Levels

    • High evidence

  • Effects of Selenium and/or N-Acetyl-Cysteine Supplementation on Nonthyroidal Illness Syndrome in Hemodialysis Patients: A Factorial Randomized Controlled Trial.

    • 2022
    • RCT
    • Pharmacology 107(9-10)
    • • Elham Shahreki
      • Mahmoud Ali Kaykhaei
      • Zahra Mosallanezhad
      • Zahra Adineh
      • Ali Mohammad Mokhtari
      • Mahdi Mohammadi
      • Razieh Hosseini
      • Razieh Hosseini
      • Aliyeh Bazi

    • PubMed: 35691282
    • DOI: 10.1159/000525094

    4 Insights on

    • Increased Thyroid Stimulating Hormone Level
    • Increased Free Triiodothyronine Level
    • Reduced Reverse T3 Level
    • Increased Serum Free Thyroxine Levels

    • High evidence

  • Safety assessment of the indigenous probiotic strain Lactiplantibacillus plantarum subsp. plantarum Kita-3 using Sprague–Dawley rats as a model

    • 2022
    • RCT · n = 18
    • AIMS Microbiology 8(4)
    • • Moh. A'inurrofiqin
      • E. Rahayu
      • D. Suroto
      • Tyas Utami
      • Yunika Mayangsari

    • PubMed: 36694579
    • DOI: 10.3934/microbiol.2022028

    10 Insights on

    • Increased Gut Lactobacillus plantarum Population
    • Reduced Bacterial Translocation
    • Maintained General Health
    • No Negative Impact on Hematological Parameters
    • Increased Bacterial Translocation
    • Enhanced Food Safety
    • Increased Bacterial Survival
    • Non-Translocation to Blood or Organs
    • Stable Organ Weight
    • Maintained Morphological Integrity

    • Low evidence
    • Animal Study