October 2020 Supplement Research Papers

• October 1

  • Lactobacillus rhamnosus Endocarditis After Upper Endoscopy

    • 2020-10-01
    • Case Report · n = 1
    • Open Forum Infectious Diseases 4(2)
    • • J. Aaron
      • M. Sobieszczyk
      • S. Weiner
      • S. Whittier
      • F. Lowy

    • PubMed: 28695143
    • DOI: 10.1093/ofid/ofx085

    2 Insights on

    • Developed Endocarditis
    • Incidence of Endocarditis

    • Low evidence

  • Lactobacillus reuteri DSM 17938 and ATCC PTA 5289 ameliorates chemotherapy-induced oral mucositis

    • 2020-10-01
    • Scientific Reports 10(1)
    • • N. Gupta
      • J. Ferreira
      • C. Hong
      • K. S. Tan

    • PubMed: 33004948
    • DOI: 10.1038/s41598-020-73292-w

    3 Insights on

    • Reduced Hepatic Oxidative Stress
    • Reduced Oral Mucositis Severity
    • Reduced Inflammation Levels

    • Low evidence
    • Rigorous Journal

  • Food-borne Lactiplantibacillus plantarum protect normal intestinal cells against inflammation by modulating reactive oxygen species and IL-23/IL-17 axis

    • 2020-10-01
    • Scientific Reports 10(1)
    • • Roberta Prete
      • N. Garcia-Gonzalez
      • C. D. Di Mattia
      • A. Corsetti
      • N. Battista

    • PubMed: 33004903
    • DOI: 10.1038/s41598-020-73201-1

    4 Insights on

    • Reduced Inflammatory Response
    • Neutralized Reactive Oxygen Species
    • Reduced Inflammatory Response in Intestinal Cells
    • Reduced Reactive Oxygen Species Formation

    • Low evidence
    • Rigorous Journal

  • Effects of heat-killed Lactobacillus casei subsp. casei 327 intake on defecation in healthy volunteers: a randomized, double-blind, placebo-controlled, parallel-group study

    • 2020-10-01
    • RCT · n = 104
    • Bioscience of Microbiota, Food and Health 37(3)
    • • Yuhi Saito
      • Toshihiro Mihara
      • M. Oki
      • T. Kumagai

    • PubMed: 30094121
    • DOI: 10.12938/bmfh.17-025

    4 Insights on

    • Increased Stool Volume
    • Increased Fecal Output
    • Improved Defecation Condition
    • Improved Bowel Movement Frequency

    • High evidence
    • Rigorous Journal

  • [Therapeutic effect of acupoint injection as adjuvant treatment on dry eyes of convalescent herpes simplex keratitis].

    • 2020-10-01
    • RCT · n = 60
    • Zhongguo zhen jiu = Chinese acupuncture & moxibustion 40(10)
    • • Guang-Hong Zhang
      • Xiao-Yu Li
      • Du-Jun Li
      • Ke-Hu Wu
      • Lin Wu
      • Ji-Hong Luo

    • PubMed: 33068350
    • DOI: 10.13703/j.0255-2930.20191230-k0008

    4 Insights on

    • Reduced Visceral Fat
    • Increased Schirmer Test Value
    • Reduced Corneal Fluorescein Staining Score
    • Increased Tear Break-Up Time

    • High evidence
• October 2

  • Lactobacillus plantarum L15 Alleviates Colitis by Inhibiting LPS-Mediated NF-κB Activation and Ameliorates DSS-Induced Gut Microbiota Dysbiosis

    • 2020-10-02
    • Frontiers in Immunology 11
    • • P. Yu
      • Chuxin Ke
      • Jiaxin Guo
      • Xiuling Zhang
      • Bailiang Li

    • PubMed: 33123156
    • DOI: 10.3389/fimmu.2020.575173

    10 Insights on

    • Increased Body Weight
    • Alleviated Histopathological Changes in the Colon
    • Increased Colon Length
    • Improved Body Weight
    • Reduced Pro-Inflammatory Cytokines
    • Reduced LPS Secretion
    • Increased Anti-Inflammatory Cytokine Levels
    • Modulated Gut Microbiota
    • Reduced Disease Activity Index (DAI) Levels
    • Reduced Myeloperoxidase Levels

    • Low evidence

  • Safety assessment of Streptococcus thermophilus IDCC 2201 used for product manufacturing in Korea

    • 2020-10-02
    • Food Science & Nutrition 8(11)
    • • O-Hyun Ban
      • S. Oh
      • Chanmi Park
      • Won Yeong Bang
      • Bo Som Lee
      • Soo-yeon Yang
      • Seung A Chae
      • Y. Jung
      • Jungwoo Yang

    • PubMed: 33282276
    • DOI: 10.1002/fsn3.1925

    6 Insights on

    • Reduced Beta-Glucuronidase Activity
    • Absence of Toxin Genes
    • Absence of Antibiotic Resistance
    • Reduced D-Lactate Production
    • Absence of Biogenic Amines Production
    • No Mortality or Toxicity

    • Low evidence

  • L-carnitine as primary or adjuvant treatment in infertile patients with varicocele. A systematic review.

    • 2020-10-02
    • Systematic Review
    • Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica 92(3)
    • • Georgios Tsampoukas
      • Muhammad Faisal Khan
      • Antigoni Katsouri
      • Waseem Akhter
      • Mohamad Moussa
      • Konstantinos Deliveliotis
      • Athanasios Papatsoris
      • Noor Buchholz

    • PubMed: 33016059
    • DOI: 10.4081/aiua.2020.3.263

    2 Insights on

    • Improved Pregnancy Rate
    • Improved Semen Quality

    • High evidence

  • Manuka honey versus saline sinus irrigation in the treatment of cystic fibrosis-associated chronic rhinosinusitis: A randomised pilot trial.

    • 2020-10-02
    • RCT · n = 13
    • Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 46(1)
    • • Victoria S Lee
      • Ian M Humphreys
      • Patricia L Purcell
      • Greg E Davis

    • PubMed: 32852889
    • DOI: 10.1111/coa.13637

    3 Insights on

    • Reduced Sinonasal Outcome Test-22 Score
    • Reduced Lund-Kennedy Endoscopic Score
    • Achieved Culture Negativity

    • High evidence
• October 4

  • Vitamin B6, vitamin B12 and methionine and risk of pancreatic cancer: a meta-analysis.

    • 2020-10-04
    • Meta-Analysis · n = 18
    • Nutrition journal 19(1)
    • • Dan-Hong Wei
      • Qi-Qi Mao

    • PubMed: 33012287
    • DOI: 10.1186/s12937-020-00628-7

    1 Insight on

    • Reduced Pancreatic Cancer Risk

    • High evidence
• October 5

  • Influence of Vitamin K on Bone Mineral Density and Osteoporosis.

    • 2020-10-05
    • Review
    • Cureus 12(10)
    • • Abeer O Elshaikh
      • Lisa Shah
      • Christopher Joy Mathew
      • Robert Lee
      • Merin Tresa Jose
      • Ivan Cancarevic

    • PubMed: 33173624
    • DOI: 10.7759/cureus.10816

    3 Insights on

    • Increased Total Hip Bone Mineral Density
    • Improved Bone Health
    • Reduced Fracture Risk

    • Low evidence

  • Supplementation with Combined Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 Across Development Reveals Sex Differences in Physiological and Behavioural Effects of Western Diet in Long–Evans Rats

    • 2020-10-05
    • Clinical Trial · n = 62
    • Microorganisms 8(10)
    • • E. M. Myles
      • M. E. O'Leary
      • R. Smith
      • Chad W. MacPherson
      • Alexandra Oprea
      • Emma H Melanson
      • T. Tompkins
      • T. Perrot

    • PubMed: 33027912
    • DOI: 10.3390/microorganisms8101527

    7 Insights on

    • Reduced Anxiety Levels
    • Increased Leptin Levels
    • Increased Inflammatory Response
    • Reduced Weight Gain
    • Reduced Anxiety-like Behavior
    • Reduced Food Intake
    • Increased Caloric Intake in Females

    • Low evidence
    • Rigorous Journal
    • Animal Study
• October 6

  • Bifidobacterium animalis ssp. Lactis 420 Mitigates Autoimmune Hepatitis Through Regulating Intestinal Barrier and Liver Immune Cells

    • 2020-10-06
    • Clinical Trial
    • Frontiers in Immunology 11
    • • Hongxia Zhang
      • Man Liu
      • Xin Liu
      • Weilong Zhong
      • Yanni Li
      • Ying Ran
      • Liping Guo
      • Xu Chen
      • Jingwen Zhao
      • Bangmao Wang
      • Lu Zhou

    • PubMed: 33123141
    • DOI: 10.3389/fimmu.2020.569104

    7 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Serum LPS Levels
    • Increased Short Chain Fatty Acids
    • Alleviated Autoimmune Hepatitis Symptoms
    • Reduced Serum Endotoxin Level
    • Improved Experimental Autoimmune Hepatitis
    • Regulated Liver Immune Homeostasis

    • Low evidence
    • Animal Study

  • L-leucine improves anemia and growth in patients with transfusion-dependent Diamond-Blackfan anemia: Results from a multicenter pilot phase I/II study from the Diamond-Blackfan Anemia Registry.

    • 2020-10-06
    • Clinical Trial · n = 55
    • Pediatric blood & cancer 67(12)
    • • Adrianna Vlachos
      • Evangelia Atsidaftos
      • Mohammad Lutfi Lababidi
      • Ellen Muir
      • Zora R Rogers
      • Waseem Alhushki
      • Jonathan Bernstein
      • Bertil Glader
      • Barbara Gruner
      • Helge Hartung
      • Christine Knoll
      • Thomas Loew
      • Grzegorz Nalepa
      • Anupama Narla
      • Arun R Panigrahi
      • Colin A Sieff
      • Kelly Walkovich
      • Jason E Farrar
      • Jeffrey M Lipton

    • PubMed: 33025707
    • DOI: 10.1002/pbc.28748

    3 Insights on

    • Improved Weight Percentile
    • Improved Erythroid Response
    • Improved Height Percentile

    • High evidence
• October 7

  • Lactobacillus rhamnosus from human breast milk shows therapeutic function against foodborne infection by multi-drug resistant Escherichia coli in mice.

    • 2020-10-07
    • Food & Function 11(1)
    • • Nan Li
      • B. Pang
      • Guanwen Liu
      • Xixi Zhao
      • Xiaoguang Xu
      • C. Jiang
      • Baowei Yang
      • Yanlin Liu
      • Junling Shi

    • PubMed: 31829373
    • DOI: 10.1039/c9fo01698h

    4 Insights on

    • Regulated Cytokine Levels
    • Reduced Inflammatory Effects
    • Restored Gut Microbiome Balance
    • Reduced Escherichia coli Counts

    • Low evidence

  • Human-origin Lactobacillus salivarius AR809 protects against immunosuppression in S. aureus-induced pharyngitis via Akt-mediated NF-κB and autophagy signaling pathways.

    • 2020-10-07
    • Clinical Trial
    • Food & Function 11(1)
    • • G. Jia
      • Xiaofeng Liu
      • N. Che
      • Yongjun Xia
      • Guangqiang Wang
      • Z. Xiong
      • Hui Zhang
      • Lian-zhong Ai

    • PubMed: 31957758
    • DOI: 10.1039/c9fo02476j

    8 Insights on

    • Improved Pharyngeal Health
    • Reduced Proinflammatory Mediators
    • Enhanced Autophagy
    • Reduced Inflammatory Response
    • Improved Immune Response
    • Reduced Severity of S. aureus-induced Pharyngitis
    • Reduced Pro-Inflammatory Mediator Production
    • Reduced Immunosuppression in Pharyngitis

    • Low evidence
    • Animal Study

  • Efficacy of proprietary Lactobacillus casei for anti-tuberculosis associated gastrointestinal adverse reactions in adult patients: a randomized, open-label, dose-response trial.

    • 2020-10-07
    • RCT · n = 429
    • Food & Function 11(1)
    • • Song Lin
      • Shanliang Zhao
      • Jiahong Liu
      • Jianwen Zhang
      • Chao Zhang
      • Haibo Hao
      • Yuxia Sun
      • Jing Cai
      • Yang Yang
      • Yan Ma
      • Yuanyuan Li
      • Jinyu Wang
      • A. Ma

    • PubMed: 31815260
    • DOI: 10.1039/c9fo01583c

    11 Insights on

    • Reduced Vomiting Duration
    • Reduced Appetite Loss
    • Reduced Duration of Anti-TB-associated Gastrointestinal Symptoms
    • Reduced Duration of Gastrointestinal Symptoms
    • Reduced Vomiting Incidence
    • Reduced Incidence of Gastrointestinal Adverse Events
    • Reduced Appetite Loss Incidence
    • Reduced Vomiting Frequency
    • Reduced Duration of Gastrointestinal Adverse Symptom
    • Reduced Gastrointestinal Adverse Events
    • Reduced Duration of Appetite Loss

    • High evidence
    • Large Human Trial
• October 8

  • The effect of curcumin ointment on knee pain in older adults with osteoarthritis: a randomized placebo trial.

    • 2020-10-08
    • RCT
    • BMC complementary medicine and therapies 20(1)
    • • Neda Jamali
      • Mohsen Adib-Hajbaghery
      • Alireza Soleimani

    • PubMed: 33032585
    • DOI: 10.1186/s12906-020-03105-0

    1 Insight on

    • Reduced Knee Pain

    • High evidence

  • Efficacy of L-Leucine Supplementation Coupled with a Calorie-Restricted Diet to Promote Weight Loss in Mid-Life Women.

    • 2020-10-08
    • RCT · n = 34
    • Journal of the American College of Nutrition 40(8)
    • • LesLee Funderburk
      • Jeffery Heileson
      • Matthew Peterson
      • Darryn S Willoughby

    • PubMed: 33030983
    • DOI: 10.1080/07315724.2020.1815607

    7 Insights on

    • Gained or Maintained Lean Mass
    • Reduced Lean Mass
    • Reduced Body Weight
    • Unchanged Resting Metabolic Rate
    • Increased Resting Metabolic Rate
    • Reduced Body Fat Mass
    • Improved Lean Mass Retention

    • High evidence
    • Rigorous Journal
• October 10

  • Research on the Effect of Pediococcus pentosaceus on Salmonella enteritidis-Infected Chicken

    • 2020-10-10
    • RCT · n = 120
    • BioMed Research International 2020
    • • D. Lan
      • XinYu Xun
      • YaoDong Hu
      • Nianzhen Li
      • Chaowu Yang
      • Xiaosong Jiang
      • Yiping Liu

    • PubMed: 33102586
    • DOI: 10.1155/2020/6416451

    5 Insights on

    • Reduced Colitis-Related Mortality
    • Regulated Inflammatory Responses
    • Reduced Mortality Rate from Salmonella Enteritidis Infection
    • Improved Gut Microbiota
    • Reduced Pathogenicity of S. Enteritidis

    • Low evidence
    • Rigorous Journal
    • Animal Study
• October 12

  • Grape seed extract supplementation along with a restricted-calorie diet improves cardiovascular risk factors in obese or overweight adult individuals: A randomized, placebo-controlled trial.

    • 2020-10-12
    • RCT
    • Phytotherapy research : PTR 35(2)
    • • Reyhaneh Yousefi
      • Maryam Parandoosh
      • Hoda Khorsandi
      • Nima Hosseinzadeh
      • Masoumeh Madani Tonekaboni
      • Atoosa Saidpour
      • Hossein Babaei
      • Arman Ghorbani

    • PubMed: 33044768
    • DOI: 10.1002/ptr.6859

    6 Insights on

    • Reduced Visceral Fat
    • Reduced Low-Density Lipoprotein Level
    • Reduced Triglyceride Levels
    • Increased HDL Cholesterol Levels
    • Reduced Atherogenic Index
    • Reduced Total Cholesterol Levels

    • High evidence

  • Effect of Bifidobacterium infantis NLS super strain in symptomatic coeliac disease patients on long-term gluten-free diet - an exploratory study.

    • 2020-10-12
    • RCT · n = 18
    • Beneficial Microbes 11(6)
    • • E. Smecuol
      • Marco Constante
      • M. P. Temprano
      • A. F. Costa
      • M. L. Moreno
      • M. Pinto-Sanchez
      • H. Vázquez
      • J. Stefanolo
      • Andrea F. Gonzalez
      • C. D’Adamo
      • S. Niveloni
      • E. Mauriño
      • Elena F Verdu
      • Julio C. Bai

    • PubMed: 33032471
    • DOI: 10.3920/BM2020.0016

    7 Insights on

    • No Increase in Adverse Effects
    • Altered Microbial Profile
    • Altered Faecal Microbiota Profile
    • Improved Coeliac Disease Symptoms
    • Reduced Gastrointestinal Symptoms
    • Improved Gastrointestinal Symptoms
    • Altered Stool Microbiota Profile

    • High evidence

  • Impact of Phyllantus niruri and Lactobacillus amylovorus SGL 14 in a mouse model of dietary hyperoxaluria.

    • 2020-10-12
    • Beneficial microbes 11(6)
    • • L Manna
      • E Rizzi
      • E Bafile
      • C Macchi
      • M Ruscica
      • R Salini
      • E Rossi
      • C Panebianco
      • V Pazienza
      • F Federici

    • PubMed: 33032472
    • DOI: 10.3920/bm2020.0008

    4 Insights on

    • Reduced Urinary Oxalic Acid Levels
    • Successful Gut Colonization
    • Reduced Urinary Oxalate Excretion
    • Improved Gut Microbiota Colonization

    • Low evidence
    • Rigorous Journal
• October 13

  • Effects of Bifidobacterium animalis Subsp. lactis (BPL1) Supplementation in Children and Adolescents with Prader-Willi Syndrome: A Randomized Crossover Trial.

    • 2020-10-13
    • RCT · n = 39
    • Nutrients 12(10)
    • • Montse Amat-Bou
      • Sonika Garcia-Ribera
      • Eric Climent
      • Irene Piquer-Garcia
      • Raquel Corripio
      • David Sanchez-Infantes
      • Laia Villalta
      • Maria Elias
      • Josep C Jiménez-Chillarón
      • Empar Chenoll
      • Daniel Ramón
      • Lourdes Ibañez
      • Marta Ramon-Krauel
      • Carles Lerin

    • PubMed: 33066107
    • DOI: 10.3390/nu12103123

    8 Insights on

    • Reduced Visceral Fat
    • Reduced Total Fat Mass
    • Improved Insulin Levels
    • Reduced Mental Health Symptom
    • Reduced Hyperphagia
    • Improved Insulin Sensitivity
    • Improved Lipid Metabolism
    • Improved Glucose Metabolism

    • High evidence
    • Rigorous Journal
• October 15

  • Effect of St. John's wort oil and olive oil on the postoperative complications after third molar surgery: randomized, double-blind clinical trial.

    • 2020-10-15
    • RCT · n = 90
    • Clinical oral investigations 25(4)
    • • Volkan Kaplan
      • Guzin Neda Hasanoglu Erbasar
      • Levent Cigerim
      • Hilal Altay Turgut
      • Abdullah Cerit

    • PubMed: 33057887
    • DOI: 10.1007/s00784-020-03639-0

    7 Insights on

    • Reduced Trismus
    • Reduced Facial Swelling
    • Reduced Bleeding on Probing (BOP)
    • Reduced Analgesic Use
    • Reduced Pain
    • Reduced Plaque Accumulation
    • Reduced Probing Pocket Depth

    • High evidence
• October 17

  • Six months vitamin K treatment does not affect systemic arterial calcification or bone mineral density in diabetes mellitus 2.

    • 2020-10-17
    • RCT · n = 68
    • European journal of nutrition 60(3)
    • • Jonas W Bartstra
      • Fieke Draaisma
      • Sabine R Zwakenberg
      • Nikolas Lessmann
      • Jelmer M Wolterink
      • Yvonne T van der Schouw
      • Pim A de Jong
      • Joline W J Beulens

    • PubMed: 33068157
    • DOI: 10.1007/s00394-020-02412-z

    2 Insights on

    • Reduced Arterial Calcification Progression
    • Increased Bone Mineral Density

    • High evidence
    • Rigorous Journal

  • Inclusion of Lactobacillus salivarius strain revealed a positive effect on improving growth performance, fecal microbiota and immunological responses in chicken

    • 2020-10-17
    • RCT
    • Archives of Microbiology 203(2)
    • • S. Sureshkumar
      • Hwi-Cheul Lee
      • Sun Keun Jung
      • Dongjun Kim
      • K. Oh
      • Hyeon Yang
      • Y. Jo
      • Haesun Lee
      • Sukchan Lee
      • S. Byun

    • PubMed: 33068123
    • DOI: 10.1007/s00203-020-02088-3

    10 Insights on

    • Reduced Serum Cytokine Levels
    • Improved Gut Health
    • Improved Fecal Microbiota
    • Improved Growth Performance
    • Improved Gut Microbiota Composition
    • Maintained Morphological Integrity
    • Improved Immunological Response
    • Stabilized Fecal Microbiota
    • Reduced Pro-inflammatory Cytokine Levels
    • Unchanged Intestinal Morphology

    • High evidence
• October 19

  • Bifidobacterium alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockade

    • 2020-10-19
    • Clinical Trial
    • Proceedings of the National Academy of Sciences 117(44)
    • • Shan Sun
      • Lingjie Luo
      • Wenhua Liang
      • Qian Yin
      • Jing Guo
      • Anthony M. Rush
      • Z. Lv
      • Q. Liang
      • M. Fischbach
      • J. Sonnenburg
      • Dylan Dodd
      • Mark M. Davis
      • Feng Wang

    • PubMed: 33077598
    • DOI: 10.1073/pnas.1921223117

    4 Insights on

    • Improved Colitis Symptoms
    • Enhanced Mitochondrial Fitness of Intestinal Regulatory T-cells
    • Enhanced Suppressive Function of Intestinal Tregs
    • Reduced Intestinal Immunopathology

    • Low evidence
    • Highly Cited
    • Animal Study

  • Identification of the key physiological characteristics of Lactobacillus plantarum strains for ulcerative colitis alleviation.

    • 2020-10-19
    • Clinical Trial
    • Food & Function 11(2)
    • • Yang Liu
      • Yingyue Sheng
      • Qiqi Pan
      • Yuzheng Xue
      • Leilei Yu
      • F. Tian
      • Jianxin Zhao
      • Hao Zhang
      • Q. Zhai
      • Wei Chen

    • PubMed: 31984399
    • DOI: 10.1039/c9fo02935d

    1 Insight on

    • Reduced Colitis Symptoms

    • Low evidence
    • Animal Study

  • The impact of L-branched-chain amino acids and L-leucine on malnutrition, sarcopenia, and other outcomes in patients with chronic liver disease.

    • 2020-10-19
    • Review
    • Expert review of gastroenterology & hepatology 15(2)
    • • Ana Luiza Soares Dos Santos
      • Lucilene Rezende Anastácio

    • PubMed: 32993404
    • DOI: 10.1080/17474124.2021.1829470

    2 Insights on

    • Reduced Malnutrition
    • Reduced Sarcopenia

    • Low evidence
• October 20

  • Improvement of glucose metabolism in pregnant women through probiotic supplementation depends on gestational diabetes status: meta-analysis.

    • 2020-10-20
    • Meta-Analysis
    • Scientific reports 10(1)
    • • Karolina Łagowska
      • Anna M Malinowska
      • Bogna Zawieja
      • Emilia Zawieja

    • PubMed: 33082439
    • DOI: 10.1038/s41598-020-74773-8

    5 Insights on

    • Improved Insulin Sensitivity
    • Improved Glucose Metabolism
    • Reduced Serum Glucose Levels
    • Reduced Insulin Levels
    • Improved Insulin Resistance

    • High evidence
    • Rigorous Journal

  • Effect of oral administration of Triphala, a polyphenol-rich prebiotic, on scalp sebum in patients with scalp seborrhea a randomized clinical trial.

    • 2020-10-20
    • RCT
    • The Journal of dermatological treatment 33(2)
    • • Elham Zareie
      • Parvin Mansouri
      • Hamed Hosseini
      • Omid Sadeghpour
      • Laila Shirbeigi
      • Someyeh Hejazi
      • Majid Emtiazy

    • PubMed: 32698634
    • DOI: 10.1080/09546634.2020.1800568

    2 Insights on

    • Improved Treatment Satisfaction
    • Reduced Scalp Sebum Level

    • High evidence
• October 21

  • Effect of Lactobacillus brevis CD2 containing lozenges and plaque pH and cariogenic bacteria in diabetic children: a randomised clinical trial

    • 2020-10-21
    • RCT · n = 8
    • Clinical Oral Investigations 25(1)
    • • S. Lai
      • P. Lingström
      • M. Cagetti
      • F. Cocco
      • G. Meloni
      • M. Arrica
      • G. Campus

    • PubMed: 33083852
    • DOI: 10.1007/s00784-020-03342-0

    5 Insights on

    • Reduced Streptococcus Mutans Density
    • Increased Plaque pH Levels
    • Improved Plaque pH Stability
    • Reduced Streptococcus Mutans Levels
    • Reduced Gingival Bleeding

    • High evidence
• October 22

  • Paraprobiotics and Postbiotics of Probiotic Lactobacilli, Their Positive Effects on the Host and Action Mechanisms: A Review.

    • 2020-10-22
    • Review
    • Frontiers in nutrition 7
    • • Tsegay Teame
      • Anran Wang
      • Mingxu Xie
      • Zhen Zhang
      • Yalin Yang
      • Qianwen Ding
      • Chenchen Gao
      • Rolf Erik Olsen
      • Chao Ran
      • Zhigang Zhou

    • PubMed: 33195367
    • DOI: 10.3389/fnut.2020.570344

    4 Insights on

    • Improved Immune Function
    • Improved Immune Response
    • Improved Immune Modulation
    • Improved Gut Barrier Function

    • Moderate evidence
    • Highly Cited
• October 23

  • Comparative Genome Analysis of Bifidobacterium longum subsp. infantis Strains Reveals Variation in Human Milk Oligosaccharide Utilization Genes among Commercial Probiotics

    • 2020-10-23
    • Nutrients 12(11)
    • • R. Duar
      • G. Casaburi
      • Ryan D. Mitchell
      • Lindsey N C Scofield
      • Camila A. Ortega Ramírez
      • D. Barile
      • B. Henrick
      • S. Frese

    • PubMed: 33114073
    • DOI: 10.3390/nu12113247

    4 Insights on

    • Improved Gut Microbiome Health
    • Improved Fitness in Breastfed Infants
    • Reduced Dysbiosis-Associated Bacteria Growth
    • Enhanced Infant Growth on Human Milk Oligosaccharides

    • Moderate evidence

  • Influence of probiotic supplementation on the developing microbiota in human preterm neonates.

    • 2020-10-23
    • Observational
    • Gut microbes 12(1)
    • • Niels van Best
      • Sonja Trepels-Kottek
      • Paul Savelkoul
      • Thorsten Orlikowsky
      • Mathias W Hornef
      • John Penders

    • PubMed: 33095113
    • DOI: 10.1080/19490976.2020.1826747

    2 Insights on

    • Reduced Incidence of Necrotizing Enterocolitis
    • Transient Gut Colonization

    • Low evidence

  • Functional Foods: An Approach to Modulate Molecular Mechanisms of Alzheimer's Disease.

    • 2020-10-23
    • Review
    • Cells 9(11)
    • • Anna Atlante
      • Giuseppina Amadoro
      • Antonella Bobba
      • Valentina Latina

    • PubMed: 33114170
    • DOI: 10.3390/cells9112347

    2 Insights on

    • Reduced Alzheimer's Disease-Related Neurotoxicity
    • Modulated Gut Microbiota

    • Low evidence

  • Bacillus coagulans GBI-30, 6086 improves amino acid absorption from milk protein

    • 2020-10-23
    • Nutrition & Metabolism 17(1)
    • • R. Stecker
      • Jessica M. Moon
      • Travis Russo
      • K. Ratliff
      • Petey W. Mumford
      • R. Jäger
      • M. Purpura
      • C. Kerksick

    • PubMed: 33110439
    • DOI: 10.1186/s12986-020-00515-2

    3 Insights on

    • Increased Amino Acid Concentration
    • Reduced Time to Maximum Amino Acid Concentration
    • Improved Amino Acid Absorption

    • Moderate evidence

  • Recommendations for the adjuvant use of the poly-antibiotic–resistant probiotic Bacillus clausii (O/C, SIN, N/R, T) in acute, chronic, and antibiotic-associated diarrhea in children: consensus from Asian experts

    • 2020-10-23
    • Tropical Diseases, Travel Medicine and Vaccines 6(1)
    • • Jo-Anne A de Castro
      • D. Kesavelu
      • K. Lahiri
      • Nataruks Chaijitraruch
      • V. Chongsrisawat
      • P. Jog
      • Y. H. Liaw
      • G. K. Nguyễn
      • Thi Viet Ha Nguyen
      • Uday A. Pai
      • Huu Nguyet Diem Phan
      • S. Quak
      • P. Tanpowpong
      • Mary Jean V. Guno

    • PubMed: 33110611
    • DOI: 10.1186/s40794-020-00120-4

    4 Insights on

    • Reduced Helicobacter Pylori Treatment-Related Symptoms
    • Reduced Antibiotic-Associated Diarrhea
    • Improved Management of Acute Viral Diarrhea
    • Prevention of C. difficile-Induced Diarrhea

    • Low evidence
    • Rigorous Journal
• October 24

  • Bifidobacteriumlongum subsp. infantis CECT7210 (B. infantis IM-1®) Displays In Vitro Activity against Some Intestinal Pathogens

    • 2020-10-24
    • Nutrients 12(11)
    • • L. Ruiz
      • A. Flórez
      • B. Sánchez
      • J. A. Moreno-Muñoz
      • M. Rodriguez-Palmero
      • J. Jiménez
      • C. G. D. L. R. Gavilán
      • M. Gueimonde
      • P. Ruas-Madiedo
      • A. Margolles

    • PubMed: 33114404
    • DOI: 10.3390/nu12113259

    12 Insights on

    • Reduced Enteropathogen Colonization
    • Reduced Growth of Cronobacter sakazakii
    • Reduced Colonization of Cronobacter sakazakii in Enterocytes
    • Reduced Cronobacter sakazakii Adhesion
    • Reduced Enteropathogen Adhesion
    • Reduced Enterocyte Layer Colonization by Salmonella enterica
    • Increased Bifidobacteria Growth
    • Reduced Clostridium difficile Infection
    • Reduced Clostridium difficile Count
    • Prevented Shigella sonnei Adhesion
    • Reduced Enteropathogen Presence in Enterocyte Layer
    • Reduced Enterocyte Pathogen Load

    • Moderate evidence
• October 26

  • Selection of Immunobiotic Ligilactobacillus salivarius Strains from the Intestinal Tract of Wakame-Fed Pigs: Functional and Genomic Studies.

    • 2020-10-26
    • Microorganisms 8(11)
    • • Binghui Zhou
      • Leonardo Albarracin
      • Yuhki Indo
      • Lorena Arce
      • Yuki Masumizu
      • Mikado Tomokiyo
      • Md Aminul Islam
      • Valeria Garcia-Castillo
      • Wakako Ikeda-Ohtsubo
      • Tomonori Nochi
      • Hidetoshi Morita
      • Hideki Takahashi
      • Shoichiro Kurata
      • Julio Villena
      • Haruki Kitazawa

    • PubMed: 33114778
    • DOI: 10.3390/microorganisms8111659

    3 Insights on

    • Reduced Viral Load
    • Reduced Infection Severity
    • Improved Intestinal Immune Response

    • Low evidence

  • Lactobacillus plantarum 06CC2 reduces hepatic cholesterol levels and modulates bile acid deconjugation in Balb/c mice fed a high‐cholesterol diet

    • 2020-10-26
    • Clinical Trial
    • Food Science & Nutrition 8(11)
    • • M. Yamasaki
      • Mikako Minesaki
      • Asuka Iwakiri
      • Y. Miyamoto
      • Kenjirou Ogawa
      • K. Nishiyama
      • Chuluunbat Tsend-Ayush
      • Tsendesuren Oyunsuren
      • Yiran Li
      • T. Nakano
      • M. Takeshita
      • Yuo Arima

    • PubMed: 33282267
    • DOI: 10.1002/fsn3.1909

    6 Insights on

    • Reduced Hepatic Damage Indices
    • Increased Butyrate Levels
    • Increased Fecal Butyrate Levels
    • Reduced Liver Damage
    • Reduced Hepatic Cholesterol
    • Increased Plasma Deconjugated Bile Acids

    • Low evidence
    • Animal Study
• October 27

  • Lactococcus lactis subsp. Cremoris C60 restores T Cell Population in Small Intestinal Lamina Propria in Aged Interleukin-18 Deficient Mice

    • 2020-10-27
    • Clinical Trial
    • Nutrients 12(11)
    • • Suguru Saito
      • N. Kakizaki
      • A. Okuno
      • T. Maekawa
      • N. Tsuji

    • PubMed: 33121026
    • DOI: 10.3390/nu12113287

    4 Insights on

    • Increased Dendritic Cell Activation
    • Enhanced Interferon Gamma Production
    • Enhanced Antigen Uptake
    • Restored T-Cell Population

    • Low evidence
    • Animal Study
• October 28

  • New strain of Pediococcus pentosaceus alleviates ethanol-induced liver injury by modulating the gut microbiota and short-chain fatty acid metabolism

    • 2020-10-28
    • RCT · n = 28
    • World Journal of Gastroenterology 26(40)
    • • Xianwan Jiang
      • Yating Li
      • Jian-zhong Ye
      • L. Lv
      • Liya Yang
      • Xiaoyuan Bian
      • Wen-rui Wu
      • Jingjing Wu
      • D. Shi
      • Qing Wang
      • D. Fang
      • Kaicen Wang
      • Qiangqiang Wang
      • Yanmeng Lu
      • Jiaojiao Xie
      • Lanjuan Li

    • PubMed: 33177795
    • DOI: 10.3748/wjg.v26.i40.6224

    9 Insights on

    • Improved Gut Microbiome Composition
    • Improved Intestinal Barrier Function
    • Reduced Liver Injury
    • Improved Liver Function
    • Increased Microbial Diversity
    • Enhanced SCFA Production
    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Inflammatory Response
    • Reduced Inflammation Levels

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • The Metabolic Effects of Cynara Supplementation in Overweight and Obese Class I Subjects with Newly Detected Impaired Fasting Glycemia: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial.

    • 2020-10-28
    • RCT
    • Nutrients 12(11)
    • • Mariangela Rondanelli
      • Antonella Riva
      • Giovanna Petrangolini
      • Pietro Allegrini
      • Luisa Bernardinelli
      • Teresa Fazia
      • Gabriella Peroni
      • Clara Gasparri
      • Mara Nichetti
      • Milena Anna Faliva
      • Maurizio Naso
      • Simone Perna

    • PubMed: 33126534
    • DOI: 10.3390/nu12113298

    15 Insights on

    • Reduced Visceral Fat
    • Reduced Apolipoprotein B to Apolipoprotein A Ratio
    • Increased HDL Cholesterol
    • Reduced Triglyceride Levels
    • Reduced Hemoglobin A1c
    • Reduced Apolipoprotein B Levels
    • Reduced LDL/HDL Ratio
    • Reduced Insulin Levels
    • Reduced A1c-Derived Average Glucose
    • Reduced Blood Cholesterol
    • Reduced LDL Cholesterol
    • Improved Apolipoprotein A Level
    • Reduced Fasting Glucose
    • Reduced Total Cholesterol Levels
    • Reduced Waist Circumference

    • High evidence
    • Rigorous Journal
• October 30

  • Lactobacillus plantarum PMO 08 as a Probiotic Starter Culture for Plant-Based Fermented Beverages

    • 2020-10-30
    • Molecules 25(21)
    • • Y. Oh
      • Tae Seok Kim
      • H. Moon
      • So Young Lee
      • Sang Yun Lee
      • G. Ji
      • K. Hwang

    • PubMed: 33143293
    • DOI: 10.3390/molecules25215056

    3 Insights on

    • Enhanced Antioxidant Activity
    • Improved Nutritional Content
    • Increased Antioxidant Activity

    • Low evidence
• October 31

  • Effects of Acute Grape Seed Extract Supplementation on Hemodynamics in Normal Body Weight and Obese Males.

    • 2020-10-31
    • RCT
    • Journal of nutritional science and vitaminology 66(5)
    • • Katherine N Dillon
      • Brian Shariffi
      • Brittany Thompson
      • Richard Steele
      • Jong-Kyung Kim

    • PubMed: 33132345
    • DOI: 10.3177/jnsv.66.427

    8 Insights on

    • Reduced Aortic Stiffness
    • Reduced Heart Rate
    • Reduced Stroke Volume
    • Reduced Cardiac Output
    • Reduced Systolic Blood Pressure
    • Reduced Total Peripheral Resistance
    • Reduced Mean Arterial Pressure
    • Reduced Diastolic Blood Pressure

    • High evidence
• Undated – 11 supplement studies

  • Aggregation, adherence, anti-adhesion and antagonistic activity properties relating to surface charge of probiotic Lactobacillus brevis gp104 against Staphylococcus aureus.

    • 2020-10
    • Microbial Pathogenesis 147
    • • M. Hojjati
      • Behrooz Alizadeh Behabahani
      • F. Falah

    • PubMed: 32763413
    • DOI: 10.1016/j.micpath.2020.104420

    14 Insights on

    • Increased Antibacterial Activity Against Pathogens
    • Improved Gut Adhesion
    • Increased Acid Resistance
    • Enhanced Food Safety
    • Reduced Staphylococcus aureus Colonization
    • Improved Gastrointestinal Resilience
    • Increased Antibacterial Activity
    • Reduced Serum Cholesterol Levels
    • Reduced Pathogen Adhesion
    • Improved Safety Profile
    • Improved Cholesterol Levels
    • Ensured Safety for Human Consumption
    • Enhanced Antibacterial Effect
    • Reduced Total Cholesterol Levels

    • Low evidence

  • The effects of Bacillus coagulans supplementation in patients with non-alcoholic fatty liver disease: A randomized, placebo-controlled, clinical trial.

    • 2020-10
    • RCT · n = 53
    • Clinical Nutrition ESPEN 39
    • • K. Abhari
      • Saeede Saadati
      • Zahra Yari
      • H. Hosseini
      • M. Hedayati
      • S. Abhari
      • S. Alavian
      • A. Hekmatdoost

    • PubMed: 32859329
    • DOI: 10.1016/j.clnesp.2020.06.020

    12 Insights on

    • Reduced Serum Gamma Glutamine Transaminase Levels
    • Reduced Serum Tumor Necrosis Factor-α
    • Reduced Serum Alanine Aminotransferase Levels
    • Reduced Liver Enzyme Levels
    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Nuclear Factor Kappa B Activation
    • Reduced Inflammatory Markers
    • Reduced Gamma-Glutamyl Transferase Levels
    • Reduced Liver Fat
    • Reduced Hepatic Steatosis
    • Reduced Serum Alanine Aminotransferase Activity
    • Improved Liver Steatosis

    • High evidence

  • Probiotic Lactobacillus fermentum KU200060 isolated from watery kimchi and its application in probiotic yogurt for oral health.

    • 2020-10
    • Microbial Pathogenesis 147
    • • Sung-Min Lim
      • N. Lee
      • Kee-Tae Kim
      • H. Paik

    • PubMed: 32758520
    • DOI: 10.1016/j.micpath.2020.104430

    6 Insights on

    • Enhanced Gut Health
    • Improved Oral Health
    • Potential Probiotic Benefits
    • Reduced Mutans Streptococcus Counts
    • Improved Antibacterial Activity
    • Reduced Streptococcus mutans Activity

    • Low evidence

  • l-Histidine Supplementation in Adults and Young Children with Atopic Dermatitis (Eczema).

    • 2020-10
    • Review · n = 98
    • The Journal of nutrition 150
    • • Neil K Gibbs

    • PubMed: 33000160
    • DOI: 10.1093/jn/nxaa200

    3 Insights on

    • Reduced Topical Corticosteroid Use
    • Reduced Eczema Area and Severity Index
    • Reduced Atopic Dermatitis Severity

    • Moderate evidence

  • Characterization and in vitro evaluation of a vaginal gel containing lactobacillus crispatus for the prevention of gonorrhea.

    • 2020-10
    • International Journal of Pharmaceutics 588
    • • K.C. N'Guessan Gnaman
      • S. Bouttier
      • A. Yéo
      • A.A.S. Aka Any-Grah
      • S. Geiger
      • N. Huang
      • V. Nicolas
      • S. Villebrun
      • H. Fayé-Ketté
      • G. Ponchel
      • A. Koffi
      • F. Agnely

    • PubMed: 32768529
    • DOI: 10.1016/j.ijpharm.2020.119733

    1 Insight on

    • Inhibition of Neisseria Gonorrhoeae Infection

    • Low evidence

  • Cultivable non-starter lactobacilli from ripened Parmigiano Reggiano cheeses with different salt content and their potential to release anti-hypertensive peptides.

    • 2020-10
    • International Journal of Food Microbiology 330
    • • D. Tagliazucchi
      • Andrea Baldaccini
      • S. Martini
      • A. Bianchi
      • V. Pizzamiglio
      • L. Solieri

    • PubMed: 32497940
    • DOI: 10.1016/j.ijfoodmicro.2020.108688

    2 Insights on

    • Increased Antioxidant Activity
    • Increased Production of Bioactive Peptides with Angiotensin Converting Enzyme Inhibitory Activity

    • Low evidence

  • Immunostimulation by Lactobacillus kefiri S-layer proteins with distinct glycosylation patterns requires different lectin partners.

    • 2020-10
    • The Journal of biological chemistry 295(42)
    • • Mariano Malamud
      • Gustavo J Cavallero
      • Adriana C Casabuono
      • Bernd Lepenies
      • María de Los Ángeles Serradell
      • Alicia S Couto

    • PubMed: 32817316
    • DOI: 10.1074/jbc.ra120.013934

    1 Insight on

    • Increased Immune System Activation

    • Low evidence
    • Animal Study

  • High intensity interval training combined with L-citrulline supplementation: Effects on physical performance in healthy older adults.

    • 2020-10
    • Review · n = 23
    • Experimental gerontology 140
    • • Buckinx F
      • Carvalho L P
      • Marcangeli V
      • Dulac M
      • Hajj Boutros G
      • Gouspillou G
      • Gaudreau P
      • Noirez P
      • Aubertin-Leheudre M

    • PubMed: 32721549
    • DOI: 10.1016/j.exger.2020.111036

    4 Insights on

    • Reduced Visceral Fat
    • Reduced Body Mass Index
    • Improved Gait Speed
    • Improved Fast-Paced Gait Speed

    • High evidence

  • Anti-obesity effect of Lactobacillus plantarum CQPC01 by modulating lipid metabolism in high-fat diet-induced C57BL/6 mice.

    • 2020-10
    • Clinical Trial
    • Journal of Food Biochemistry 44(12)
    • • Y. Gan
      • Ming-Wei Tang
      • Fang Tan
      • Xianrong Zhou
      • Ling Fan
      • Yu-Xin Xie
      • Xin Zhao

    • PubMed: 33006202
    • DOI: 10.1111/jfbc.13491

    6 Insights on

    • Reduced Body Weight
    • Reduced Inflammatory Markers
    • Reduced Pathological Changes of Liver
    • Increased Anti-Inflammatory Cytokine Levels
    • Reduced Hepatic Fat Accumulation
    • Reduced Adipose Cell Volume

    • Low evidence
    • Animal Study

  • Comparison of the effects of Pueraria mirifica gel and of placebo gel on the vaginal microenvironment of postmenopausal women with Genitourinary Syndrome of Menopause (GSM).

    • 2020-10
    • RCT
    • Maturitas 140
    • • Chuleekorn Sritonchai
      • Jittima Manonai
      • Areepan Sophonsritsuk
      • Wichai Cherdshewasart

    • PubMed: 32972635
    • DOI: 10.1016/j.maturitas.2020.06.005

    6 Insights on

    • Reduced Nugent Score
    • Reduced Bacterial Vaginosis
    • Improved Genitourinary Symptoms
    • Reduced Vaginal pH
    • Reduced Fungal Infection
    • Increased Vaginal Lactobacilli Levels

    • High evidence

  • Intake of Lactiplantibacillus plantarum HEAL9 reduces the inflammatory markers soluble fractalkine and CD163 during acute stress: A randomized, double blind, placebo-controlled study

    • 2020-10
    • RCT · n = 70
    • Physiology & Behavior 225
    • • G. Önning
      • M. Hillman
      • M. Hedin
      • C. Montelius
      • J. Eriksson
      • S. Ahrné
      • P. Jönsson

    • PubMed: 32687924
    • DOI: 10.1016/j.physbeh.2020.113083

    1 Insight on

    • Reduced Inflammatory Response

    • High evidence