September 2021 Supplement Research Papers

• September 1

  • Low dose red yeast rice with monacolin K lowers LDL cholesterol and blood pressure in Japanese with mild dyslipidemia: A multicenter, randomized trial.

    • 2021-09-01
    • RCT
    • Asia Pacific journal of clinical nutrition 30(3)
    • • Takuya Minamizuka
      • Masaya Koshizaka
      • Mayumi Shoji
      • Masaya Yamaga
      • Aiko Hayashi
      • Kana Ide
      • Shintaro Ide
      • Takumi Kitamoto
      • Kenichi Sakamoto
      • Akiko Hattori
      • Takahiro Ishikawa
      • Junji Kobayashi
      • Yoshiro Maezawa
      • Kazuki Kobayashi
      • Minoru Takemoto
      • Masaru Inagaki
      • Akira Endo
      • Koutaro Yokote

    • PubMed: 34587702
    • DOI: 10.6133/apjcn.202109_30(3).0009

    4 Insights on

    • Reduced Apolipoprotein B Levels
    • Reduced Blood Cholesterol
    • Reduced Low-Density Lipoprotein Level
    • Reduced Blood Pressure

    • High evidence

  • The effect of Gymnema sylvestre supplementation on glycemic control in type 2 diabetes patients: A systematic review and meta-analysis.

    • 2021-09-01
    • Meta-Analysis · n = 419
    • Phytotherapy research : PTR 35(12)
    • • Suneel Devangan
      • Bincy Varghese
      • Ebin Johny
      • Surender Gurram
      • Ramu Adela

    • PubMed: 34467577
    • DOI: 10.1002/ptr.7265

    5 Insights on

    • Reduced Blood Cholesterol
    • Reduced Triglyceride Levels
    • Reduced Hemoglobin A1c
    • Reduced Postprandial Glucose
    • Reduced Fasting Blood Glucose Levels

    • High evidence

  • Serenoa repens for the treatment of lower urinary tract symptoms due to benign prostatic enlargement: A systematic review and meta-analysis.

    • 2021-09-01
    • Meta-Analysis · n = 853
    • Investigative and clinical urology 62(5)
    • • Leonel Fabrizio Trivisonno
      • Nadia Sgarbossa
      • Gustavo Ariel Alvez
      • Cecilia Fieiras
      • Camila Micaela Escobar Liquitay
      • Jae Hung Jung
      • Juan Víctor Ariel Franco

    • PubMed: 34488251
    • DOI: 10.4111/icu.20210254

    2 Insights on

    • Improved Quality of Life
    • Reduced Urinary Symptom

    • High evidence

  • [Therapeutic effect of hydrocortisone combined with vitamin C and vitamin B1 on patients with sepsis: a Meta-analysis].

    • 2021-09-01
    • Meta-Analysis · n = 816
    • Zhonghua wei zhong bing ji jiu yi xue 33(9)
    • • Chenyang Chang
      • Kaiyuan Luo
      • Huifang Zhu
      • Guoping Deng
      • Qiannan Gao

    • PubMed: 34839858
    • DOI: 10.3760/cma.j.cn121430-20210728-01101

    6 Insights on

    • Reduced Vasoactive Drug Duration
    • Reduced Acute Kidney Injury Rate
    • Reduced Sequential Organ Failure Assessment Score
    • Reduced Length of Hospital Stay
    • Reduced Intensive Care Unit Length of Stay
    • Reduced Mortality Risk

    • High evidence
• September 2

  • The Effects of Korean Red Ginseng on Biological Aging and Antioxidant Capacity in Postmenopausal Women: A Double-Blind Randomized Controlled Study.

    • 2021-09-02
    • RCT · n = 63
    • Nutrients 13(9)
    • • Tae-Ha Chung
      • Ji-Hye Kim
      • So-Young Seol
      • Yon-Ji Kim
      • Yong-Jae Lee

    • PubMed: 34578969
    • DOI: 10.3390/nu13093090

    1 Insight on

    • Reduced Fatigue

    • High evidence
    • Rigorous Journal
• September 4

  • Safflower (Carthamus tinctorius L.) oil could improve abdominal obesity, blood pressure, and insulin resistance in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled clinical trial.

    • 2021-09-04
    • RCT · n = 67
    • Journal of ethnopharmacology 282
    • • Maede Ruyvaran
      • Ali Zamani
      • Alireza Mohamadian
      • Mohammad M Zarshenas
      • Mohammad Hassan Eftekhari
      • Saeedeh Pourahmad
      • Ebrahim Fallahzadeh Abarghooei
      • Abolfazl Akbari
      • Majid Nimrouzi

    • PubMed: 34487844
    • DOI: 10.1016/j.jep.2021.114590

    12 Insights on

    • Reduced Systolic Blood Pressure
    • Reduced Blood Cholesterol
    • Reduced LDL Cholesterol
    • Increased Adiponectin Levels
    • Reduced Triglyceride Levels
    • Increased HDL Cholesterol Levels
    • Reduced Diastolic Blood Pressure
    • Reduced Uric Acid Levels
    • Improved Insulin Sensitivity
    • Reduced Creatinine
    • Reduced Fasting Blood Glucose Levels
    • Reduced Waist Circumference

    • High evidence
• September 5

  • Co-Culture Strategy of Lactobacillus kefiranofaciens HL1 for Developing Functional Fermented Milk

    • 2021-09-05
    • Foods 10(9)
    • • Sheng-Yao Wang
      • Renhuang Huang
      • Ker-Sin Ng
      • Yen-Po Chen
      • J. Shiu
      • Ming-Ju Chen

    • PubMed: 34574208
    • DOI: 10.3390/foods10092098

    2 Insights on

    • Improved Anti-Aging Effects
    • Increased Antioxidant Activity

    • Low evidence
    • Rigorous Journal
• September 6

  • Are all dietary fibers equal for patients with inflammatory bowel disease? A systematic review of randomized controlled trials.

    • 2021-09-06
    • Systematic Review
    • Nutrition reviews 80(5)
    • • Vera Peters
      • Gerard Dijkstra
      • Marjo J E Campmans-Kuijpers

    • PubMed: 34486663
    • DOI: 10.1093/nutrit/nuab062

    3 Insights on

    • Increased Remission Rate
    • Improved Disease Course
    • Reduced Symptom Severity

    • High evidence
• September 7

  • The Many Faces of Enterococcus spp.—Commensal, Probiotic and Opportunistic Pathogen

    • 2021-09-07
    • Microorganisms 9(9)
    • • B. Krawczyk
      • Paweł Wityk
      • M. Gałęcka
      • M. Michalik

    • PubMed: 34576796
    • DOI: 10.3390/microorganisms9091900

    4 Insights on

    • Modulated Immune System
    • Increased Risk of Opportunistic Pathogenicity
    • Increased Antimicrobial Resistance
    • Improved Intestinal Microbiota Balance

    • Moderate evidence
    • Highly Cited
    • Rigorous Journal

  • Effects of Bifidobacterium Lactis BS01 and Lactobacillus Acidophilus LA02 on cognitive functioning in healthy women.

    • 2021-09-07
    • RCT · n = 53
    • Applied neuropsychology. Adult 30(5)
    • • Dominik Czajeczny
      • Karolina Kabzińska
      • Rafał Wojciech Wójciak

    • PubMed: 34493130
    • DOI: 10.1080/23279095.2021.1967155

    2 Insights on

    • Improved Cognitive Function
    • Improved Delayed Memory

    • High evidence
• September 8

  • L-Citrulline Supplementation and Exercise in the Management of Sarcopenia.

    • 2021-09-08
    • RCT · n = 44
    • Nutrients 13(9)
    • • Alberto Caballero-García
      • Jorge Pascual-Fernández
      • David César Noriega-González
      • Hugo J Bello
      • Antoni Pons-Biescas
      • Enrique Roche
      • Alfredo Córdova-Martínez

    • PubMed: 34579009
    • DOI: 10.3390/nu13093133

    7 Insights on

    • Reduced Muscle Damage Marker
    • Improved Strength
    • Increased Vitamin D Level
    • Improved Endurance
    • Reduced Cortisol Levels
    • Improved Walking Speed
    • Increased Testosterone Level

    • High evidence
    • Rigorous Journal

  • Safety Aspects of the Use of Isolated Piperine Ingested as a Bolus.

    • 2021-09-08
    • Review
    • Foods (Basel, Switzerland) 10(9)
    • • Rainer Ziegenhagen
      • Katharina Heimberg
      • Alfonso Lampen
      • Karen Ildico Hirsch-Ernst

    • PubMed: 34574230
    • DOI: 10.3390/foods10092121

    3 Insights on

    • Impaired Spermatogenesis
    • Reduced Reproductive Function
    • Increased Drug Bioavailability

    • Low evidence

  • Anti-inflammatory potential of Lactiplantibacillus plantarum IDCC 3501 and its safety evaluation

    • 2021-09-08
    • Brazilian Journal of Microbiology 52(4)
    • • Soo-yeon Yang
      • Seung A Chae
      • Won Yeong Bang
      • Minjee Lee
      • O-Hyun Ban
      • Soo‐Jung Kim
      • Y. Jung
      • Jungwoo Yang

    • PubMed: 34495527
    • DOI: 10.1007/s42770-021-00603-2

    4 Insights on

    • Enhanced Food Safety
    • Reduced Inflammatory Response
    • Improved Cell Viability
    • Absence of Acute Toxicity

    • Low evidence
    • Rigorous Journal

  • Comparison of the Probiotic Potential between Lactiplantibacillus plantarum Isolated from Kimchi and Standard Probiotic Strains Isolated from Different Sources

    • 2021-09-08
    • Foods 10(9)
    • • C. Jeong
      • Hyejin Sohn
      • Hyelyeon Hwang
      • Ho-Jae Lee
      • Tae-Woon Kim
      • Dong-Sub Kim
      • Chun-Sung Kim
      • S. Han
      • S. Hong

    • PubMed: 34574235
    • DOI: 10.3390/foods10092125

    9 Insights on

    • Reduced Pro-Inflammatory Cytokines
    • Increased Intestinal Cell Adhesion
    • Increased Antioxidant Activity
    • Improved Antibacterial Activity
    • Improved Cell Viability
    • Increased Anti-Inflammatory Cytokine Levels
    • Improved Thermotolerance
    • Reduced Inflammation Levels
    • Increased Antibacterial Activity

    • Low evidence
    • Rigorous Journal

  • The effect of nanomicelle curcumin supplementation and Nigella sativa oil on the expression level of miRNA-21, miRNA-422a, and miRNA-503 gene in postmenopausal women with low bone mass density: A randomized, triple-blind, placebo-controlled clinical trial with factorial design.

    • 2021-09-08
    • RCT · n = 30
    • Phytotherapy research : PTR 35(11)
    • • Azizeh Farshbaf-Khalili
      • Safar Farajnia
      • Samira Pourzeinali
      • Seyed Kazem Shakouri
      • Hanieh Salehi-Pourmehr

    • PubMed: 34496087
    • DOI: 10.1002/ptr.7259

    3 Insights on

    • Increased miRNA-422a Expression
    • Increased miRNA-503 Expression
    • Increased miRNA-21 Expression

    • High evidence

  • Phenyl-Lactic Acid Is an Active Ingredient in Bactericidal Supernatants of Lactobacillus crispatus

    • 2021-09-08
    • Journal of Bacteriology 203(19)
    • • O. Abdul-Rahim
      • Qihao Wu
      • T. Price
      • G. Pistone
      • Katherine Diebel
      • T. Bugni
      • A. Wolfe

    • PubMed: 34280003
    • DOI: 10.1128/JB.00360-21

    1 Insight on

    • Protected Bladder Microbiome

    • Low evidence
• September 9

  • Effect of Origanum dubium, Origanum vulgare subsp. hirtum, and Lavandula angustifolia essential oils on lipid profiles and liver biomarkers in athletes.

    • 2021-09-09
    • RCT
    • Zeitschrift fur Naturforschung. C, Journal of biosciences 77(5-6)
    • • Hasan Maral
      • Süleyman Ulupınar
      • Ayşegül Türk Baydır
      • Serhat Özbay
      • Konca Altınkaynak
      • Engin Şebin
      • Erdinç Şiktar
      • Necip Fazıl Kishalı
      • Yusuf Buzdağlı
      • Cebrail Gençoğlu
      • İzzet İnce

    • PubMed: 34496170
    • DOI: 10.1515/znc-2021-0142

    5 Insights on

    • Decreased Triglyceride Level
    • Altered Liver Biomarker Level
    • Reduced Low-Density Lipoprotein Level
    • Increased HDL Cholesterol Levels
    • Reduced Total Cholesterol Levels

    • High evidence
• September 10

  • Infantile Colic Treated With Bifidobacterium longum CECT7894 and Pediococcus pentosaceus CECT8330: A Randomized, Double-Blind, Placebo-Controlled Trial

    • 2021-09-10
    • RCT · n = 112
    • Frontiers in Pediatrics 9
    • • Ke Chen
      • Changqi Liu
      • Hua Li
      • Yuehua Lei
      • Chenggui Zeng
      • Shuhong Xu
      • Jianqiu Li
      • F. Savino

    • PubMed: 34568236
    • DOI: 10.3389/fped.2021.635176

    2 Insights on

    • Reduced Crying Duration
    • Improved Stool Consistency

    • High evidence

  • Chinese Herbal Medicine Significantly Impacts the Haematological Variables of the Athlete Biological Passport.

    • 2021-09-10
    • RCT
    • International journal of environmental research and public health 18(18)
    • • William Chih-Wei Chang
      • Chih-Yuan Wang
      • Wan-Yi Liu
      • Chin-Chuan Tsai
      • Yu-Tse Wu
      • Mei-Chich Hsu

    • PubMed: 34574458
    • DOI: 10.3390/ijerph18189533

    2 Insights on

    • Reduced OFF-hr Score
    • Increased Reticulocyte Percentage

    • High evidence
• September 15

  • Kabasura Kudineer (KSK), a poly-herbal Siddha medicine, reduced SARS-CoV-2 viral load in asymptomatic COVID-19 individuals as compared to vitamin C and zinc supplementation: findings from a prospective, exploratory, open-labeled, comparative, randomized controlled trial, Tamil Nadu, India.

    • 2021-09-15
    • RCT
    • Trials 22(1)
    • • S Natarajan
      • C Anbarasi
      • P Sathiyarajeswaran
      • P Manickam
      • S Geetha
      • R Kathiravan
      • P Prathiba
      • M Pitchiahkumar
      • P Parthiban
      • K Kanakavalli
      • P Balaji

    • PubMed: 34526104
    • DOI: 10.1186/s13063-021-05583-0

    7 Insights on

    • Reduced Viral Load
    • Reduced Interleukin-2 Level
    • Reduced Interferon-gamma Level
    • Reduced Interleukin-10 Levels
    • Prevented Progression from Asymptomatic to Symptomatic COVID-19
    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Interleukin-6 Levels

    • High evidence

  • Evaluation of probiotic characteristics and whole genome analysis of Pediococcus pentosaceus MR001 for use as probiotic bacteria in shrimp aquaculture

    • 2021-09-15
    • Clinical Trial
    • Scientific Reports 11(1)
    • • Warapond Wanna
      • K. Surachat
      • Panmile Kaitimonchai
      • A. Phongdara

    • PubMed: 34526534
    • DOI: 10.1038/s41598-021-96780-z

    6 Insights on

    • Improved Digestive Enzyme Activity
    • Improved Intestinal Histology
    • Improved Cell Survival Rates
    • Improved Gut Health
    • Enhanced Digestive Enzyme Activity
    • Increased Body Weight

    • Low evidence
    • Rigorous Journal
    • Animal Study
• September 17

  • The effects of co-administration of artichoke leaf extract supplementation with metformin and vitamin E in patients with nonalcoholic fatty liver disease: A randomized clinical trial.

    • 2021-09-17
    • RCT
    • Phytotherapy research : PTR 35(11)
    • • Mohammad Bagher Majnooni
      • Mari Ataee
      • Gholamreza Bahrami
      • Fatemeh Heydarpour
      • Ina Yosifova Aneva
      • Mohammad Hosein Farzaei
      • Touraj Ahmadi-Juoibari

    • PubMed: 34533249
    • DOI: 10.1002/ptr.7279

    4 Insights on

    • Reduced Aspartate Aminotransferase Level
    • Reduced Alanine Aminotransferase Level
    • Increased Proportion of Grade 0 Fatty Liver
    • Reduced Hepatic Fat Accumulation

    • High evidence
• September 18

  • A Saccharomyces cerevisiae Fermentation Product (Olimond BB) Alters the Early Response after Influenza Vaccination in Racehorses.

    • 2021-09-18
    • Clinical Trial
    • Animals : an open access journal from MDPI 11(9)
    • • Alexandra Lucassen
      • Christa Finkler-Schade
      • Hans-Joachim Schuberth

    • PubMed: 34573692
    • DOI: 10.3390/ani11092726

    3 Insights on

    • Increased Antibody Response
    • Modulated Immune Response
    • Improved Specific Antibody Response

    • Moderate evidence
• September 21

  • Lactobacillus plantarum and Lactobacillus brevis Alleviate Intestinal Inflammation and Microbial Disorder Induced by ETEC in a Murine Model

    • 2021-09-21
    • RCT · n = 24
    • Oxidative Medicine and Cellular Longevity 2021
    • • Xuebing Han
      • Sujuan Ding
      • Yong Ma
      • Jun Fang
      • Hongmei Jiang
      • Yi Li
      • Gang Liu

    • PubMed: 34594475
    • DOI: 10.1155/2021/6867962

    13 Insights on

    • Reduced Proinflammatory Factor Levels
    • Reduced Morphological Damage of the Jejunum
    • Reduced Gut Inflammation
    • Stabilized Fecal Microbiota
    • Stabilized Gut Microbiota
    • Reduced Proinflammatory Factors
    • Increased Probiotic Bacteria Abundance
    • Reduced Body Weight
    • Reduced Potential Pathogenic Bacteria
    • Reduced Intestinal Inflammation
    • Reduced Pathogenic Bacteria in Gut
    • Reduced Pathogenic Bacterial Abundance
    • Improved Intestinal Microbiota

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Effectiveness of Probiotics and Prebiotics Against Acute Liver Injury: A Meta-Analysis.

    • 2021-09-21
    • Systematic Review
    • Frontiers in medicine 8
    • • Sheng Xu
      • Min Zhao
      • Qinjian Wang
      • Zhihua Xu
      • Binhui Pan
      • Yilang Xue
      • Zebin Dai
      • Sisi Wang
      • Zhanxiong Xue
      • Fangyan Wang
      • Changlong Xu

    • PubMed: 34621765
    • DOI: 10.3389/fmed.2021.739337

    4 Insights on

    • Reduced Liver Injury Indicators
    • Improved Gut Barrier Function
    • Reduced Oxidative Stress
    • Reduced Inflammation

    • High evidence

  • Effect of brown seaweed on plasma glucose in healthy, at-risk, and type 2 diabetic individuals: systematic review and meta-analysis.

    • 2021-09-21
    • Meta-Analysis
    • Nutrition reviews 80(5)
    • • Kate Vaughan
      • Viren Ranawana
      • David Cooper
      • Magaly Aceves-Martins

    • PubMed: 34549293
    • DOI: 10.1093/nutrit/nuab069

    2 Insights on

    • Improved Fasting Plasma Glucose
    • Reduced Postprandial Glucose

    • High evidence
• September 22

  • Acute L-Citrulline Supplementation Increases Nitric Oxide Bioavailability but Not Inspiratory Muscle Oxygenation and Respiratory Performance.

    • 2021-09-22
    • Clinical Trial
    • Nutrients 13(10)
    • • Anastasios A Theodorou
      • Panagiotis T Zinelis
      • Vassiliki J Malliou
      • Panagiotis N Chatzinikolaou
      • Nikos V Margaritelis
      • Dimitris Mandalidis
      • Nickos D Geladas
      • Vassilis Paschalis

    • PubMed: 34684312
    • DOI: 10.3390/nu13103311

    5 Insights on

    • Improved Respiratory Performance
    • Improved Pulmonary Function
    • Improved Inspiratory Muscle Oxygenation
    • Improved Maximal Inspiratory Pressure
    • Increased Fractional Exhaled Nitric Oxide

    • High evidence
    • Rigorous Journal

  • Turmeric root extract supplementation improves pre-frontal cortex oxygenation and blood volume in older males and females: a randomised cross-over, placebo-controlled study.

    • 2021-09-22
    • RCT
    • International journal of food sciences and nutrition 73(2)
    • • Cristina Rezende
      • Gustavo Vieira de Oliveira
      • Mônica Volino-Souza
      • Patrícia Castro
      • Juan Manuel Murias
      • Thiago Silveira Alvares

    • PubMed: 34551650
    • DOI: 10.1080/09637486.2021.1972411

    5 Insights on

    • Reduced Heart Rate
    • Reduced Systolic Blood Pressure
    • Improved Cerebral Oxygenation
    • Reduced Diastolic Blood Pressure
    • Increased Cerebral Blood Volume

    • High evidence
• September 23

  • Relative Efficacy of Vitamin D2 and Vitamin D3 in Improving Vitamin D Status: Systematic Review and Meta-Analysis.

    • 2021-09-23
    • Meta-Analysis
    • Nutrients 13(10)
    • • Rakesh Balachandar
      • Raghu Pullakhandam
      • Bharati Kulkarni
      • Harshpal Singh Sachdev

    • PubMed: 34684328
    • DOI: 10.3390/nu13103328

    3 Insights on

    • Increased 25-hydroxyvitamin D Level
    • Reduced Parathyroid Hormone Level
    • Increased Serum 25-Hydroxyvitamin D Level

    • High evidence
    • Rigorous Journal
• September 24

  • Clostridium butyricum Supplement Can Ameliorate the Intestinal Barrier Roles in Broiler Chickens Experimentally Infected With Clostridium perfringens

    • 2021-09-24
    • RCT
    • Frontiers in Physiology 12
    • • Xiao Xu
      • Shunli Yang
      • J. S. Olajide
      • Z. Qu
      • Zhenxing Gong
      • Jing Wang
      • Yanbing Zhang
      • Heng Wang
      • Ling Xiong
      • Kun Zhang
      • E. Zhou
      • Jiong Cai

    • PubMed: 34630156
    • DOI: 10.3389/fphys.2021.737481

    7 Insights on

    • Improved Immunity Status
    • Improved Intestinal Morphology
    • Reduced Plasma Lipopolysaccharide Levels
    • Reduced FITC-Dextran Flux Upregulation
    • Improved Growth Performance
    • Normalized Serum IgA Levels
    • Enhanced Intestinal Barrier Function

    • High evidence
• September 25

  • The effects of capsinoids and fermented red pepper paste supplementation on Glycaemic Control: A systematic review and meta-analysis of randomised controlled trials.

    • 2021-09-25
    • Meta-Analysis · n = 530
    • International journal of clinical practice 75(12)
    • • Mohammad Reza Amini
      • Alireza Talebyan
      • Nastaran Payandeh
      • Fatemeh Sheikhhossein
      • Fatemeh Mohtashaminia
      • Fatemeh Gholami

    • PubMed: 34487384
    • DOI: 10.1111/ijcp.14803

    4 Insights on

    • Reduced Blood Glucose Levels
    • Reduced Hemoglobin A1c
    • Improved Insulin Levels
    • Reduced HOMA-IR

    • High evidence
• September 26

  • Patient Nutrition and Probiotic Therapy in COVID-19: What Do We Know in 2021?

    • 2021-09-26
    • Review · n = 19
    • Nutrients 13(10)
    • • Viktoria Hawryłkowicz
      • Danuta Lietz-Kijak
      • Karolina Kaźmierczak-Siedlecka
      • Joanna Sołek-Pastuszka
      • Laura Stachowska
      • Marcin Folwarski
      • Miłosz Parczewski
      • Ewa Stachowska

    • PubMed: 34684384
    • DOI: 10.3390/nu13103385

    2 Insights on

    • Reduced Risk of COVID-19 Progression
    • Improved Immune Modulation

    • Moderate evidence
    • Rigorous Journal
• September 27

  • Effects of artichoke leaf extract supplementation or artichoke juice consumption on lipid profile: A systematic review and dose-response meta-analysis of randomized controlled trials.

    • 2021-09-27
    • Systematic Review
    • Phytotherapy research : PTR 35(12)
    • • Hossein Shahinfar
      • Elham Bazshahi
      • Mohammad Reza Amini
      • Nastaran Payandeh
      • Sanaz Pourreza
      • Zahra Noruzi
      • Sakineh Shab-Bidar

    • PubMed: 34569671
    • DOI: 10.1002/ptr.7247

    4 Insights on

    • Reduced Low-Density Lipoprotein Level
    • Reduced Triglyceride Levels
    • Increased HDL Cholesterol Levels
    • Reduced Total Cholesterol Levels

    • High evidence
• September 28

  • The Effect of Lactobacillus gasseri BNR17 on Postmenopausal Symptoms in Ovariectomized Rats

    • 2021-09-28
    • Clinical Trial
    • Journal of Microbiology and Biotechnology 31(9)
    • • Sol Lee
      • D. Jung
      • Miri Park
      • S. Yeon
      • Sang-Hyuk Jung
      • S. Yun
      • Han-Oh Park
      • Wonbeak Yoo

    • PubMed: 34319260
    • DOI: 10.4014/jmb.2105.05032

    12 Insights on

    • Reduced Alveolar Bone Resorption
    • Increased Serotonin 2A Receptor Levels
    • Reduced Menopausal Symptoms
    • Elevated Calcitonin Levels
    • Improved Bone Mass Density
    • Reduced Pain Intensity
    • Improved Vaginal Cornification
    • Reduced Pain Sensitivity
    • Reduced Serum Alanine Aminotransferase Levels
    • Increased Bone Mineral Density
    • Reduced Serum Osteocalcin Levels
    • Reduced Urine Deoxypyridinoline Levels

    • Low evidence
    • Animal Study
• September 29

  • The potential of Streptococcus thermophiles (TCI633) in the anti‐aging

    • 2021-09-29
    • Journal of Cosmetic Dermatology 21(6)
    • • Cheng Liu
      • Ya-Ping Tseng
      • Leong‐Perng Chan
      • C. Liang

    • PubMed: 34587358
    • DOI: 10.1111/jocd.14445

    13 Insights on

    • Improved Serum Biochemical HA Levels
    • Reduced Hyaluronidase Activity
    • Increased Collagen Content
    • Improved Skin Cell Proliferation
    • Improved Skin Condition
    • Improved Serum Biochemical Catalase Levels
    • Improved Serum Hyaluronan Levels
    • Delayed Skin Aging
    • Increased Hyaluronic Acid Production
    • Increased Collagen Synthesis
    • Reduced DNA Damage
    • Increased Catalase Activity
    • Increased Superoxide Dismutase Levels

    • Low evidence
    • Rigorous Journal
• September 30

  • Lactobacillus mediates the expression of NPC1L1, CYP7A1, and ABCG5 genes to regulate cholesterol.

    • 2021-09-30
    • Review
    • Food science & nutrition 9(12)
    • • Kaihui Cao
      • Kaiping Zhang
      • Muran Ma
      • Junjie Ma
      • Jianjun Tian
      • Ye Jin

    • PubMed: 34925816
    • DOI: 10.1002/fsn3.2600

    3 Insights on

    • Reduced Intestinal Cholesterol Absorption
    • Reduced Blood Cholesterol
    • Improved Homeostasis

    • Low evidence
• Undated – 10 supplement studies

  • Effects of Withania somnifera (Ashwagandha) on Stress and the Stress- Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia.

    • 2021-09
    • Review
    • Current neuropharmacology 19(9)
    • • Alex B Speers
      • Kadine A Cabey
      • Amala Soumyanath
      • Kirsten M Wright

    • PubMed: 34254920
    • DOI: 10.2174/1570159x19666210712151556

    4 Insights on

    • Reduced Anxiety
    • Reduced Stress
    • Improved Depressive Symptoms
    • Improved Insomnia

    • Moderate evidence
    • Highly Cited

  • Effects of Bacillus subtilis and Bacillus licheniformis on growth performance, immunity, short chain fatty acid production, antioxidant capacity, and cecal microflora in broilers

    • 2021-09
    • RCT · n = 360
    • Poultry Science 100(9)
    • • Yinglei Xu
      • Yang Yu
      • Yuanyuan Shen
      • Qing Li
      • J. Lan
      • Yan-ping Wu
      • Ruiqiang Zhang
      • Guantian Cao
      • Caimei Yang

    • PubMed: 34358955
    • DOI: 10.1016/j.psj.2021.101358

    6 Insights on

    • Improved Immune Function
    • Improved Short-Chain Fatty Acid Production
    • Improved Antioxidant Capacity
    • Increased Short-Chain Fatty Acid Production
    • Improved Growth Performance
    • Enhanced Immunity

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Effects of Lactobacillus acidophilus on the growth performance, immune response, and intestinal barrier function of broiler chickens challenged with Escherichia coli O157

    • 2021-09
    • RCT · n = 360
    • Poultry Science 100(9)
    • • Zhengke Wu
      • Kexin Yang
      • A. Zhang
      • Wenhuan Chang
      • A. Zheng
      • Zhi-Min Chen
      • Huiyi Cai
      • Guohua Liu

    • PubMed: 34280647
    • DOI: 10.1016/j.psj.2021.101323

    14 Insights on

    • Modulated Immune Response
    • Improved Intestinal Function
    • Improved Cell Survival Rates
    • Reduced Colitis-Related Mortality
    • Reduced Inflammatory Response
    • Improved Immune Response
    • Improved Intestinal Barrier Function
    • Reduced Inflammatory Markers
    • Improved Growth Performance
    • Modulated Inflammatory Response
    • Reduced Mortality Rate
    • Improved Survival Rate
    • Reduced Inflammation Levels
    • Improved Gastrointestinal Health

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Mastiha has efficacy in immune-mediated inflammatory diseases through a microRNA-155 Th17 dependent action.

    • 2021-09
    • RCT
    • Pharmacological research 171
    • • Charalampia Amerikanou
      • Efstathia Papada
      • Aristea Gioxari
      • Ilias Smyrnioudis
      • Stamatia-Angeliki Kleftaki
      • Evdokia Valsamidou
      • Victoria Bruns
      • Rajarshi Banerjee
      • Maria Giovanna Trivella
      • Natasa Milic
      • Milica Medić-Stojanoska
      • Amalia Gastaldelli
      • Aimo Kannt
      • George V Dedoussis
      • Andriana C Kaliora

    • PubMed: 34224858
    • DOI: 10.1016/j.phrs.2021.105753

    2 Insights on

    • Reduced Interleukin-6 Levels
    • Reduced miR-155 Level

    • High evidence

  • The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial.

    • 2021-09
    • RCT · n = 271
    • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 141
    • • Ali Shahriari
      • Elham Karimi
      • Mohammadali Shahriari
      • Neda Aslani
      • Maryam Khooshideh
      • Arman Arab

    • PubMed: 34328109
    • DOI: 10.1016/j.biopha.2021.111915

    3 Insights on

    • Reduced Prevalence of Gestational Diabetes Mellitus
    • Reduced Postprandial Glucose
    • Reduced Fasting Blood Glucose Levels

    • High evidence
    • Large Human Trial

  • N-acetyl cysteine versus standard of care for non-acetaminophen induced acute liver injury: a systematic review and meta-analysis.

    • 2021-09
    • Meta-Analysis · n = 11
    • Annals of hepatology 24
    • • Dhan Bahadur Shrestha
      • Pravash Budhathoki
      • Yub Raj Sedhai
      • Anurag Adhikari
      • Ayusha Poudel
      • Barun Aryal
      • Ramkaji Baniya

    • PubMed: 33722689
    • DOI: 10.1016/j.aohep.2021.100340

    3 Insights on

    • Reduced Length of Hospital Stay
    • Reduced Mortality Risk
    • Reduced Hepatic Encephalopathy

    • High evidence

  • Lipidomic changes of LDL after consumption of Camelina sativa oil, fatty fish and lean fish in subjects with impaired glucose metabolism-A randomized controlled trial.

    • 2021-09
    • RCT · n = 40
    • Journal of clinical lipidology 15(5)
    • • Arja T Erkkilä
      • Suvi Manninen
      • Linda Fredrikson
      • Monika Bhalke
      • Minna Holopainen
      • Maija Ruuth
      • Maria Lankinen
      • Reijo Käkelä
      • Katariina Öörni
      • Ursula S Schwab

    • PubMed: 34548243
    • DOI: 10.1016/j.jacl.2021.08.060

    2 Insights on

    • Reduced LDL Aggregation
    • Modified LDL Phosphatidylcholine Composition

    • High evidence

  • Review of Clinical Effects and Presumed Mechanism of Action of the French Oak Wood Extract Robuvit.

    • 2021-09
    • Review · n = 1,172
    • Journal of medicinal food 24(9)
    • • Franziska Weichmann
      • Fabrice Avaltroni
      • Carolina Burki

    • PubMed: 33512270
    • DOI: 10.1089/jmf.2020.0165

    2 Insights on

    • Improved Liver Function
    • Improved Renal Function

    • High evidence

  • A randomized, double blind, parallel, placebo‐controlled study to investigate the efficacy of Lactobacillus paracasei N1115 in gut development of young children

    • 2021-09
    • RCT · n = 58
    • Food Science & Nutrition 9(11)
    • • Shijie Wang
      • Yiping Xun
      • Grace J Ahern
      • Lili Feng
      • Dong Zhang
      • Yuling Xue
      • R. Ross
      • Andrea M Doolan
      • C. Stanton
      • Hong Zhu

    • PubMed: 34760234
    • DOI: 10.1002/fsn3.2533

    2 Insights on

    • Increased Lactobacilli Levels
    • Stable Bowel Function

    • High evidence

  • Complete genome sequence of Lactobacillus amylovorus 1394N20, a potential probiotic strain, isolated from a Hanwoo calf

    • 2021-09
    • Journal of Animal Science and Technology 63(5)
    • • Young Joon Oh
      • Joon-Yong Kim
      • Jieun Lee
      • S. Lim
      • Dohyeon Yu
      • Yeonsu Oh
      • Jinho Park
      • Hak-Jong Choi

    • PubMed: 34796359
    • DOI: 10.5187/jast.2021.e100

    2 Insights on

    • Improved Digestibility
    • Improved Gut Health

    • Low evidence
    • Rigorous Journal