April 2025 Supplement Research Papers

• April 1

  • Probiotic Supplements Effect on Feeding Tolerance, Growth and Neonatal Morbidity in Extremely Preterm Infants: A Systematic Review and Meta-Analysis.

    • 2025-04-01
    • Meta-Analysis · n = 14
    • Nutrients 17(7)
    • • Sofia Söderquist Kruth
      • Emma Persad
      • Alexander Rakow

    • PubMed: 40218986
    • DOI: 10.3390/nu17071228

    4 Insights on

    • Reduced All-Cause Mortality
    • Reduced Necrotising Enterocolitis
    • Improved Feeding Tolerance
    • Reduced Duration of Parenteral Nutrition

    • High evidence
    • Rigorous Journal

  • Colonic goblet cell-associated antigen passages mediate physiologic and beneficial translocation of live gut bacteria in preweaning mice.

    • 2025-04-01
    • Nature microbiology 10(4)
    • • Sreeram Udayan
      • Alexandria N Floyd
      • Vini John
      • Bibiana E Barrios
      • Brigida A Rusconi
      • Keely G McDonald
      • Ellen Merrick Schill
      • Devesha H Kulkarni
      • Andrew L Martin
      • Rafael Gutierrez
      • Khushi B Talati
      • Dalia L Harris
      • Sushma Sundas
      • Kayla M Burgess
      • Jocelyn T Pauta
      • Elisabeth L Joyce
      • Jacqueline D Wang
      • Leslie D Wilson
      • Kathryn A Knoop
      • Phillip I Tarr
      • Chyi-Song Hsieh
      • Rodney D Newberry

    • PubMed: 40169738
    • DOI: 10.1038/s41564-025-01965-1

    2 Insights on

    • Reduced Risk of Sepsis
    • Reduced Sepsis

    • Low evidence
    • Animal Study

  • The Effect of Gut Microbiome Perturbation on the Bioavailability of Glycyrrhizic Acid in Rats.

    • 2025-04-01
    • Pharmaceutics 17(4)
    • • Tiantian Shi
      • Huifang Li
      • Zihao Zhang
      • Yuying Zang
      • Shu Jiang
      • Tianjie Yuan

    • PubMed: 40284452
    • DOI: 10.3390/pharmaceutics17040457

    1 Insight on

    • Increased Glycyrrhetinic Acid Bioavailability

    • Low evidence
• April 2

  • Efficacy of different pharmaceutical forms of Curcuma longa or curcumin in reducing oral mucositis severity and incidence in cancer patients: a systematic review and meta-analysis.

    • 2025-04-02
    • Systematic Review · n = 159
    • Frontiers in pharmacology 16
    • • Pedro de Padua G Amatto
      • Lucas Chaves
      • Suzelei de Castro França
      • José Carlos Tavares Carvalho
      • Fabio Carmona
      • Ana Maria Soares Pereira

    • PubMed: 40242451
    • DOI: 10.3389/fphar.2025.1560729

    2 Insights on

    • Reduced Oral Pain
    • Reduced Oral Mucositis Severity

    • High evidence

  • Nasal delivery of killed Bacillus subtilis spores protects against influenza, RSV and SARS-CoV-2.

    • 2025-04-02
    • Frontiers in immunology 16
    • • Rong Xu
      • Huynh A Hong
      • Shadia Khandaker
      • Murielle Baltazar
      • Noor Allehyani
      • Daan Beentjes
      • Tessa Prince
      • Yen-Linh Ho
      • Linh Hanh Nguyen
      • Daniel Hynes
      • William Love
      • Simon M Cutting
      • Aras Kadioglu

    • PubMed: 40242757
    • DOI: 10.3389/fimmu.2025.1501907

    3 Insights on

    • Reduced Disease Severity
    • Reduced Infection Severity
    • Reduced Inflammatory Infiltrate

    • Low evidence

  • Effects of Eight-Week Supplementation Containing Red Orange and Polypodium leucotomos Extracts on UVB-Induced Skin Responses: A Randomized Double-Blind Placebo-Controlled Trial.

    • 2025-04-02
    • RCT
    • Nutrients 17(7)
    • • Petra Keršmanc
      • Tina Pogačnik
      • Janko Žmitek
      • Hristo Hristov
      • Olga Točkova
      • Katja Žmitek

    • PubMed: 40218997
    • DOI: 10.3390/nu17071240

    3 Insights on

    • Increased Minimal Erythema Dose
    • Reduced Erythema Intensity
    • Reduced Pigmentation Change

    • High evidence
    • Rigorous Journal
• April 4

  • Metagenomic evaluation, antimicrobial activities, and immune stimulation of probiotics from dietary supplements and dairy products.

    • 2025-04-04
    • Scientific reports 15(1)
    • • Piyaorn Chornchoem
      • Sarunporn Tandhavanant
      • Natnaree Saiprom
      • Anucha Preechanukul
      • Nartthawee Thongchompoo
      • Insee Sensorn
      • Wasun Chantratita
      • Narisara Chantratita

    • PubMed: 40185827
    • DOI: 10.1038/s41598-025-95664-w

    5 Insights on

    • Enhanced Immune Response
    • Increased Antibacterial Activity
    • Reduced Proinflammatory Cytokine Production
    • Improved Immune Modulation
    • Enhanced Anti-Inflammatory Cytokine Production

    • Low evidence
    • Rigorous Journal

  • Long-term gamma-aminobutyric acid (GABA) treatment fails to regain beta-cell function in longstanding type 1 diabetes in a randomized trial.

    • 2025-04-04
    • RCT
    • Scientific reports 15(1)
    • • Henrik Hill
      • Per Lundkvist
      • Georgios Tsatsaris
      • Bryndis Birnir
      • Daniel Espes
      • Per-Ola Carlsson

    • PubMed: 40185824
    • DOI: 10.1038/s41598-025-95751-y

    4 Insights on

    • Improved Insulin Sensitivity
    • Reduced Hemoglobin A1c
    • Improved Glycemia
    • Improved Hormonal Counter-Regulation

    • High evidence
    • Rigorous Journal
• April 5

  • Role of Bifidobacterium animalis subsp. lactis BB-12 in mice with acute pancreatitis.

    • 2025-04-05
    • AMB Express 15(1)
    • • Bingbing Du
      • Ren Yan
      • Xiaoxiang Hu
      • Jing Lou
      • Yixin Zhu
      • Yini Shao
      • Huiyong Jiang
      • Yingying Hao
      • Longxian Lv

    • PubMed: 40186645
    • DOI: 10.1186/s13568-025-01867-9

    5 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Acute Pancreatitis Severity
    • Reduced Pancreatic Inflammation
    • Reduced Pancreatic Inflammatory and Metabolic Dysregulation
    • Reduced Pancreatic Stress-Related Pathways

    • Low evidence

  • Effects of Lactobacillus paracei JY062 Postbiotic on Intestinal Barrier, Immunity, and Gut Microbiota.

    • 2025-04-05
    • Nutrients 17(7)
    • • Jinfeng Guo
      • Ying Zhao
      • Wenqian Guo
      • Yilin Sun
      • Wei Zhang
      • Qianyu Zhao
      • Yu Zhang
      • Yujun Jiang

    • PubMed: 40219029
    • DOI: 10.3390/nu17071272

    4 Insights on

    • Improved Intestinal Barrier Function
    • Increased Short-Chain Fatty Acid Production
    • Reduced Inflammation
    • Improved Phagocytic Activity

    • Low evidence
    • Rigorous Journal

  • Data-Driven Monitoring of Probiotic Fermentation in Fruit Juices Using Near-Infrared Spectroscopy and Aquaphotomics: An Innovative Approach to Food Valorization.

    • 2025-04-05
    • Foods (Basel, Switzerland) 14(7)
    • • Lueji Regatieri
      • Flora Vitalis
      • Erika Bujna
      • Quang Duc Nguyen
      • Zoltan Kovacs

    • PubMed: 40238555
    • DOI: 10.3390/foods14071274

    1 Insight on

    • No Human Health Outcome Reported

    • Low evidence
• April 6

  • Effects of Tribulus (Tribulus terrestris L.) Supplementation on Erectile Dysfunction and Testosterone Levels in Men-A Systematic Review of Clinical Trials.

    • 2025-04-06
    • Systematic Review · n = 172
    • Nutrients 17(7)
    • • José de Oliveira Vilar Neto
      • Wilson Max Almeida Monteiro de Moraes
      • Daniel Vieira Pinto
      • Carlos Alberto da Silva
      • Juan de Sá Roriz Caminha
      • Júlio César Chaves Nunes Filho
      • Caio Eduardo Gonçalves Reis
      • Jonato Prestes
      • Heitor O Santos
      • Elizabeth De Francesco Daher

    • PubMed: 40219032
    • DOI: 10.3390/nu17071275

    2 Insights on

    • Improved Erectile Dysfunction
    • Increased Testosterone Level

    • High evidence
    • Rigorous Journal
• April 7

  • The Encapsulation Strategies for Targeted Delivery of Probiotics in Preventing and Treating Colorectal Cancer: A Review.

    • 2025-04-07
    • Review
    • Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12(18)
    • • Hao Zhong
      • Jin Jiang
      • Muhammad Hussain
      • Haoxuan Zhang
      • Ling Chen
      • Rongfa Guan

    • PubMed: 40192333
    • DOI: 10.1002/advs.202500304

    2 Insights on

    • Improved Gut Microbiota Balance
    • Reduced Risk of Colorectal Cancer

    • Low evidence

  • Lactobacillus acidophilus potentiates oncolytic virotherapy through modulating gut microbiota homeostasis in hepatocellular carcinoma.

    • 2025-04-07
    • Nature communications 16(1)
    • • Jiayu Zhang
      • Jinneng Yang
      • Jinyan Luo
      • Weili Wu
      • Haidan Luo
      • Wenxia Wei
      • Haimei Lyu
      • Yuzhi Wang
      • Hairong Yi
      • Yijing Zhang
      • Zongmin Fan
      • Haiwen Lyu
      • Vishnu Priya Kanakaveti
      • Baifu Qin
      • Ping Yuan
      • Runxiang Yang
      • Haipeng Zhang
      • Tao Zuo
      • Dean W Felsher
      • Mong-Hong Lee
      • Kai Li

    • PubMed: 40195307
    • DOI: 10.1038/s41467-025-58407-z

    3 Insights on

    • Improved Barrier Integrity
    • Improved Gut Microbiota Homeostasis
    • Improved Oncolytic Virotherapy Efficacy

    • Moderate evidence
    • Rigorous Journal

  • 3'-Sialyllactose and B. infantis synergistically alleviate gut inflammation and barrier dysfunction by enriching cross-feeding bacteria for short-chain fatty acid biosynthesis.

    • 2025-04-07
    • Gut microbes 17(1)
    • • Mingzhi Yang
      • Zipeng Jiang
      • Lutong Zhou
      • Nana Chen
      • Huan He
      • Wentao Li
      • Zhixin Yu
      • Siming Jiao
      • Deguang Song
      • Yizhen Wang
      • Mingliang Jin
      • Zeqing Lu

    • PubMed: 40195063
    • DOI: 10.1080/19490976.2025.2486512

    3 Insights on

    • Improved Intestinal Barrier Function
    • Increased Short-Chain Fatty Acid Production
    • Reduced Gut Inflammation

    • Low evidence
• April 8

  • Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus.

    • 2025-04-08
    • Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12(21)
    • • Shunfen Zhang
      • Ruqing Zhong
      • Miao Zhou
      • Kai Li
      • Huiyuan Lv
      • Huixin Wang
      • Ye Xu
      • Dadan Liu
      • Qiugang Ma
      • Liang Chen
      • Hongfu Zhang

    • PubMed: 40200426
    • DOI: 10.1002/advs.202415948

    1 Insight on

    • Reduced Intestinal Inflammation

    • Low evidence
    • Animal Study

  • Probiotics and prebiotics: new treatment strategies for oral potentially malignant disorders and gastrointestinal precancerous lesions.

    • 2025-04-08
    • Review
    • NPJ biofilms and microbiomes 11(1)
    • • Zhuwei Huang
      • Jiaye Zhu
      • Xiangwen Bu
      • Shulai Lu
      • Yixian Luo
      • Ting Liu
      • Ning Duan
      • Wenmei Wang
      • Yong Wang
      • Xiang Wang

    • PubMed: 40199865
    • DOI: 10.1038/s41522-025-00688-9

    1 Insight on

    • Reduced Oral Pathogen Growth

    • Low evidence
• April 9

  • Impact of Probiotic Formula (Lacto-5X) on Constipation: Improvements in Gastrointestinal Symptoms, Gut Microbiome, and Metabolites.

    • 2025-04-09
    • RCT
    • Journal of microbiology and biotechnology 35
    • • Yoo-Jeong Jin
      • Young Jae Park
      • Jieun Choi
      • Myung-Soo Kim
      • Uigi Min
      • Jonghyun Lim
      • Jooyeon Kang
      • Do Yup Lee
      • Byung-Yong Kim

    • PubMed: 40223270
    • DOI: 10.4014/jmb.2412.12056

    2 Insights on

    • Improved Constipation
    • Altered Metabolite Profile

    • High evidence

  • Vitamin supplementation and its effect on incident type 1 diabetes mellitus and islet autoimmunity: a systematic review and meta-analysis.

    • 2025-04-09
    • Meta-Analysis
    • Frontiers in immunology 16
    • • Chen Ee Low
      • Nicole Shi Min Chew
      • Sounak Rana
      • Sean Loke
      • Run Ting Chin
      • Shih Ling Kao
      • Ainsley Ryan Yan Bin Lee
      • Sen Hee Tay

    • PubMed: 40270966
    • DOI: 10.3389/fimmu.2025.1505324

    2 Insights on

    • Developed Type 1 Diabetes
    • Developed Islet Autoimmunity

    • High evidence

  • Sport supplementation in competitive swimmers: a systematic review with meta-analysis.

    • 2025-04-09
    • Meta-Analysis
    • Journal of the International Society of Sports Nutrition 22(1)
    • • Raúl Domínguez
      • Inmaculada López-León
      • Javier Moreno-Lara
      • Esteban Rico
      • Antonio J Sánchez-Oliver
      • Ángela Sánchez-Gómez
      • Javier Pecci

    • PubMed: 40205676
    • DOI: 10.1080/15502783.2025.2486988

    1 Insight on

    • Improved Swimming Performance

    • High evidence

  • The Potential of Probiotics in Reducing Ventilator-Associated Pneumonia: A Literature-Based Analysis.

    • 2025-04-09
    • Review
    • Microorganisms 13(4)
    • • Tao-An Chen
      • Ya-Ting Chuang
      • Szu-Chi Pai
      • Jin-Fu Zheng

    • PubMed: 40284692
    • DOI: 10.3390/microorganisms13040856

    1 Insight on

    • Reduced Ventilator-Associated Pneumonia

    • Low evidence

  • Microbiome and metabolome explain the high-fat diet-induced diabetes development and diabetes resistance in Guizhou mini-pigs.

    • 2025-04-09
    • Frontiers in microbiology 16
    • • Yanjun Wu
      • Jiayuan Mo
      • Qianguang Wang
      • Jialong Li
      • Jia Wei
      • Nuo Zhang
      • Yuanqiu Dong
      • Xiang Zhu
      • Taofeng Lu
      • Sicheng Huang

    • PubMed: 40291804
    • DOI: 10.3389/fmicb.2025.1555069

    1 Insight on

    • Diabetes Progression

    • Low evidence
• April 10

  • Synbiotic combination of Bifidobacterium longum BB536 and lactulose improves the presenteeism of healthy adults associated with aromatic lactic acids - A single-arm, open-label study.

    • 2025-04-10
    • Clinical Trial
    • Gut microbes reports 2(1)
    • • Riko Mishima
      • Ryuta Ejima
      • Satoshi Arai
      • Ayako Horigome
      • Eri Mitsuyama
      • Hiroki Kaneko
      • Kana Yamaguchi
      • Keita Kamezaki
      • Yuka Togashi
      • Kiyoshi Nakamura
      • Noriyuki Iwabuchi
      • Miyuki Tanaka
      • Toshitaka Odamaki
      • Shinji Fukuda
      • Yuji Naito

    • PubMed: 41909908
    • DOI: 10.1080/29933935.2025.2490092

    3 Insights on

    • Improved Bowel Function
    • Improved Presenteeism
    • Improved Well-Being

    • Moderate evidence

  • Oral Intake of Streptococcus thermophilus iHA318 Mitigates Dry Eye Symptoms in a Randomized Clinical Study.

    • 2025-04-10
    • RCT · n = 68
    • Biomedicines 13(4)
    • • Chieh-Hung Yen
      • Yu-Wei Chang
      • Yen-Ling Sun
      • Yi-Yun Hung
      • Wei-Chieh Liao
      • Tsung-Han Lu
      • Pin-Chao Huang
      • Han-Hsin Chang
      • Meei-Yn Lin
      • David Pei-Cheng Lin

    • PubMed: 40299529
    • DOI: 10.3390/biomedicines13040931

    1 Insight on

    • Improved Dry Eye Symptoms

    • High evidence
• April 14

  • Renal protective effects of vitamin E for drug-induced kidney injury: a meta-analysis.

    • 2025-04-14
    • Systematic Review
    • Frontiers in pharmacology 16
    • • Lingfei Meng
      • Shengmao Liu
      • Wenpeng Cui

    • PubMed: 40297145
    • DOI: 10.3389/fphar.2025.1461792

    3 Insights on

    • Reduced Creatinine Level
    • Improved eGFR
    • Reduced Acute Kidney Injury

    • High evidence
• April 17

  • Bioprocessing of Sargassum fusiforme via Lactobacillus Fermentation: Effects on Nutrient Composition, Organoleptic Properties, and In Vitro Antioxidant and Hypoglycemic Activities.

    • 2025-04-17
    • Foods (Basel, Switzerland) 14(8)
    • • Chao Zhang
      • Houyun Zhang
      • Shengli Lin
      • Laijin Su

    • PubMed: 40282786
    • DOI: 10.3390/foods14081385

    3 Insights on

    • Improved Glycemic Control
    • Improved Antioxidant Activity
    • Reduced Glycemic Enzyme Inhibition

    • Low evidence
• April 18

  • Evaluation of in vivo supplementation of 2660 mg D-aspartic acid and 200 mg ubiquinol and 10 mg zinc on different semen parameters in idiopathic male infertility: a randomized double blind placebo controlled study.

    • 2025-04-18
    • RCT · n = 75
    • Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica 97(2)
    • • Sameh Fayek GamalEl Din
      • Elnashar A M
      • Yasser Elkhiat
      • Tarek Hussein
      • Mohamed Ahmed AbdElSalam
      • Ayman Alam
      • David Ramzy
      • Islam Moatamed
      • Ashraf Zeidan
      • Amr Elahwany
      • Mohamed Wael Ragab
      • Omar Zahran
      • Hany Saad

    • PubMed: 40248985
    • DOI: 10.4081/aiua.2025.13554

    2 Insights on

    • Improved Progressive Sperm Motility
    • Increased Total Testosterone Level

    • High evidence

  • Protective effects of Bifidobacterium longum subsp. longum BL21 against cyclophosphamide-induced reproductive dysfunction in zebrafish.

    • 2025-04-18
    • Scientific reports 15(1)
    • • Yao Dong
      • Jiazhi Zhou
      • Hairui Tian
      • Zhonghui Gai
      • Kang Zou
      • Quanwei Wei
      • Mei Han

    • PubMed: 40251294
    • DOI: 10.1038/s41598-025-97721-w

    1 Insight on

    • Improved Reproductive Health

    • Low evidence
    • Rigorous Journal
    • Animal Study
• April 20

  • Probiotic Lactobacillus rhamnosus GG Alleviates Prehypertension and Restores Gut Health and Microbiota in NaCl-Induced Prehypertensive Rats.

    • 2025-04-20
    • Probiotics and antimicrobial proteins 18(1)
    • • Anis Munira Zaharuddin
      • Azdayanti Muslim
      • Shafiq Aazmi
      • Mohd Yusri Idorus
      • Fayez A Almabhouh
      • Shu Yong Lim
      • Aswini Leela Loganathan
      • Qasim Ayub
      • Chun Wie Chong
      • Khalilah Abdul Khalil
      • Nurunajah Ab Ghani
      • Siong Meng Lim
      • Kalavathy Ramasamy

    • PubMed: 40254701
    • DOI: 10.1007/s12602-025-10536-z

    4 Insights on

    • Reduced Blood Pressure
    • Improved Gut Integrity
    • Improved Serum Biochemistry
    • Restored Gut Microbiota

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Twelve-Week Colostrum Bovinum Supplementation Supports Aerobic Capacity but has No Effect on Body Composition in Endurance-Trained Males: A Randomized Placebo-Controlled Crossover Study.

    • 2025-04-20
    • RCT
    • European journal of sport science 25(5)
    • • Krzysztof Durkalec-Michalski
      • Natalia Główka
      • Tomasz Podgórski
      • Krystian Wochna
      • Małgorzata Woźniewicz
      • Paulina M Nowaczyk

    • PubMed: 40254930
    • DOI: 10.1002/ejsc.12288

    7 Insights on

    • Improved Body Composition
    • Reduced Body Mass
    • Increased Time to Ventilatory Threshold
    • Increased Oxygen Uptake at Ventilatory Threshold
    • Increased Power Output at Ventilatory Threshold
    • Increased Time to Exhaustion
    • Reduced Blood Lactate Level

    • High evidence
• April 22

  • β-Glucosidase Activity of Lactiplantibacillus plantarum: A Key Player in Food Fermentation and Human Health.

    • 2025-04-22
    • Review
    • Foods (Basel, Switzerland) 14(9)
    • • Gianluca Paventi
      • Catello Di Martino
      • Francesca Coppola
      • Francesca Coppola
      • Massimo Iorizzo

    • PubMed: 40361534
    • DOI: 10.3390/foods14091451

    1 Insight on

    • Improved Glycemia

    • Low evidence

  • A Systematic Review of Thiamine Supplementation in Improving Diabetes and Its Related Cardiovascular Dysfunction.

    • 2025-04-22
    • Systematic Review
    • International journal of molecular sciences 26(9)
    • • Maria Serra
      • Rocco Mollace
      • Giovanna Ritorto
      • Sara Ussia
      • Carmen Altomare
      • Annamaria Tavernese
      • Mariaimmacolata Preianò
      • Ernesto Palma
      • Carolina Muscoli
      • Vincenzo Mollace
      • Roberta Macrì

    • PubMed: 40362174
    • DOI: 10.3390/ijms26093932

    5 Insights on

    • Improved Insulin Sensitivity
    • Reduced Hyperglycemic Response
    • Reduced Cardiovascular Risk
    • Improved Cardiac Function
    • Reduced Heart Failure

    • High evidence
    • Rigorous Journal

  • Anticancer effects of vitamin K combined with transarterial chemoembolization in hepatocellular carcinoma, a randomized controlled trial.

    • 2025-04-22
    • RCT · n = 51
    • British journal of cancer 132(12)
    • • Yoshimichi Haruna
      • Takayuki Yakushijin
      • Miho Yamakawa
      • Tetsuo Nakazawa

    • PubMed: 40263401
    • DOI: 10.1038/s41416-025-03022-4

    3 Insights on

    • Improved Progression-free Survival
    • Improved Objective Response Rate
    • Reduced Adverse Event

    • High evidence

  • Premeal Whey Protein Lowers Postprandial Blood Glucose in Women With Gestational Diabetes Mellitus: A Randomized, Crossover Clinical Trial.

    • 2025-04-22
    • RCT
    • Diabetes care 48(6)
    • • Stine Smedegaard
      • Ulla Kampmann
      • Per G Ovesen
      • Louise B Suder
      • Janni H Knudsen
      • Gregers Wegener
      • Lise H Brunsgaard
      • Nikolaj Rittig

    • PubMed: 40261798
    • DOI: 10.2337/dc24-2831

    3 Insights on

    • Reduced Postprandial Blood Glucose
    • Reduced Peak Glucose
    • Reduced Postprandial Glucose Level

    • High evidence
• April 23

  • Coculture of Bifidobacterium bifidum G9-1 With Butyrate-Producing Bacteria Promotes Butyrate Production.

    • 2025-04-23
    • Microbiology and immunology 69(7)
    • • Haruka Yokota
      • Yoshiki Tanaka
      • Hiroshi Ohno

    • PubMed: 40269463
    • DOI: 10.1111/1348-0421.13224

    1 Insight on

    • Increased Butyrate Production

    • Low evidence

  • Probiotic Lactobacillus sp. as a strategy for modulation of non-comorbid obesity: A systematic meta-analysis and GRADE assessment of randomized controlled trials.

    • 2025-04-23
    • Meta-Analysis · n = 58
    • Narra J 5(2)
    • • Juan Ajmn Lele
      • Karlos B Sihaloho
      • Dewa Vighneshwara
      • Derren Dch Rampengan
      • Chrisandi Y Rizqiansyah
      • Happy K Permatasari
      • Nelly Mayulu
      • Trina E Tallei
      • Nurpudji A Taslim
      • Bonglee Kim
      • Immanuelle Kezia
      • Fahrul Nurkolis
      • Rony A Syahputra

    • PubMed: 40951500
    • DOI: 10.52225/narra.v5i2.1562

    9 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Leptin Levels
    • Reduced Body Weight
    • Increased Adiponectin Levels
    • Reduced Body Fat
    • Reduced Hip Circumference
    • No Significant Adverse Events
    • Absence of Serious Adverse Events

    • High evidence

  • Efficacy of lactoferrin in preventing recurrent urinary tract infections in pregnant Egyptian women: a randomized controlled trial.

    • 2025-04-23
    • RCT · n = 874
    • BMC urology 25(1)
    • • Ahmed Shoukry
      • Yasser ElKassar
      • Michaella K Hezagirwa
      • Rehab El-Said

    • PubMed: 40264102
    • DOI: 10.1186/s12894-025-01725-7

    3 Insights on

    • Reduced Asymptomatic Bacteriuria Episode
    • Reduced Acute Cystitis Episode
    • Reduced Pyelonephritis Episode

    • High evidence
    • Large Human Trial
• April 24

  • Probiotics as technological innovations in psychiatric disorders: patents and research reviews.

    • 2025-04-24
    • Systematic Review
    • Frontiers in nutrition 12
    • • Alyne Almeida de Lima
      • Sthefane Silva Santos
      • Mykaella Andrade de Araújo
      • Gabriel Vinderola
      • Cristiane Flora Villarreal
      • Max Denisson Maurício Viana

    • PubMed: 40342368
    • DOI: 10.3389/fnut.2025.1567097

    2 Insights on

    • Reduced Depression Symptoms
    • Reduced Anxiety

    • High evidence

  • Microbiome, Potential Therapeutic Agents: New Players of Obesity Treatment.

    • 2025-04-24
    • Review
    • Journal of microbiology and biotechnology 35
    • • Maqsood Ali
      • Navid Iqbal
      • Md Abdur Rakib
      • Kyung-Ah Lee
      • Mi-Hwa Lee
      • Yong-Sik Kim

    • PubMed: 40295195
    • DOI: 10.4014/jmb.2501.01024

    3 Insights on

    • Reduced Adipogenesis
    • Increased Adipose Browning
    • Reduced Adiposity

    • Low evidence
• April 25

  • Effects of probiotics, prebiotics, synbiotics and postbiotics on pediatric asthma: a systematic review.

    • 2025-04-25
    • Systematic Review · n = 419
    • Frontiers in nutrition 12
    • • Die Fan
      • Jilei Hu
      • Ning Lin

    • PubMed: 40352259
    • DOI: 10.3389/fnut.2025.1586129

    7 Insights on

    • Reduced Inflammation
    • Improved Pulmonary Function
    • Reduced Asthma Exacerbations
    • Reduced Healthcare Costs
    • Reduced Airway Hyperresponsiveness
    • Reduced Viral Respiratory Infection
    • Reduced Asthma Exacerbation

    • High evidence

  • Effects of Protein Supplementation During High-Intensity Functional Training on Physical Performance in Recreationally Trained Males and Females: A Randomized Controlled Trial.

    • 2025-04-25
    • RCT
    • Nutrients 17(9)
    • • Christina Karpouzi
      • Ioannis Kosmidis
      • Anatoli Petridou
      • Gabriela Voulgaridou
      • Sousana K Papadopoulou
      • Gregory C Bogdanis
      • Vassilis Mougios

    • PubMed: 40362749
    • DOI: 10.3390/nu17091441

    5 Insights on

    • Increased Maximal Oxygen Uptake
    • Increased Maximal Strength
    • Improved Force-Velocity Relationship
    • Increased Peak Torque of Knee Extensor and Flexor
    • Improved Strength Endurance

    • High evidence
    • Rigorous Journal
• April 28

  • The Effect of the L-Carnitine Supplementation on Obesity Indices: An Umbrella Meta-Analysis.

    • 2025-04-28
    • Meta-Analysis · n = 352
    • International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 95(2)
    • • Fatemeh Hamedi-Kalajahi
      • Meysam Zarezadeh
      • Mahsa Malekahmadi
      • Parsa Jamilian
      • Parmida Jamilian
      • Roghayeh Molani-Gol
      • Alireza Ostadrahimi

    • PubMed: 40298161
    • DOI: 10.31083/ijvnr40033

    3 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Body Weight

    • High evidence

  • Efficiency of Different Supplements in Alleviating Symptoms of ADHD with or Without the Use of Stimulants: A Systematic Review.

    • 2025-04-28
    • Systematic Review
    • Nutrients 17(9)
    • • Shatha Al Shahab
      • Rawan Al Balushi
      • Amna Qambar
      • Ruqayah Abdulla
      • Maryam Qader
      • Shooq Abdulla
      • Haitham Jahrami

    • PubMed: 40362791
    • DOI: 10.3390/nu17091482

    5 Insights on

    • Improved Attention Span
    • Improved Memory Function
    • Improved Sleep Efficiency
    • Reduced Hyperactivity
    • Reduced ADHD Symptoms

    • High evidence
    • Rigorous Journal

  • Effects of L-glutamine and hyaluronic acid associated with photobiomodulation on oral mucositis: a randomized clinical trial.

    • 2025-04-28
    • RCT · n = 24
    • Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 33(5)
    • • Rodrigo Wilmes Dos Santos
      • Allisson Filipe Lopes Martins
      • Sebastião Silvério Sousa-Neto
      • Marília Oliveira Morais
      • Victor Hugo Lopes de Oliveira Moreira
      • Diego Antonio Costa Arantes
      • Angélica Ferreira Oton-Leite
      • Nilceana Maya Aires Freitas
      • Cláudio Rodrigues Leles
      • Elismauro Francisco Mendonça

    • PubMed: 40295318
    • DOI: 10.1007/s00520-025-09480-z

    3 Insights on

    • Improved Quality of Life
    • Reduced Oral Mucositis Severity
    • Reduced Oral Mucositis Symptoms

    • High evidence

  • Comparison of qRT-PCR and ddPCR for multi-strain probiotic detection after a randomized human clinical trial.

    • 2025-04-28
    • Clinical Trial
    • Frontiers in microbiology 16
    • • Nicolas Yeung
      • Arthur C Ouwehand

    • PubMed: 40356649
    • DOI: 10.3389/fmicb.2025.1579797

    3 Insights on

    • Increased Probiotic Consumption
    • Probiotic Detection
    • Improved Lower Limit of Detection

    • Moderate evidence

  • Effects of Pomegranate on Vascular Endothelial Function: A Systematic Review and Meta-Analysis of Clinical Trials.

    • 2025-04-28
    • Meta-Analysis
    • Journal of dietary supplements 22(4)
    • • Asma Kazemi
      • Noushin Deylami
      • Sara Shojaei-Zarghani
      • Mohammad Hashem Hashempur

    • PubMed: 40296437
    • DOI: 10.1080/19390211.2025.2490659

    2 Insights on

    • Reduced Interleukin-6 Levels
    • Reduced Soluble Intercellular Adhesion Molecule-1 Level

    • High evidence
• April 30

  • Nutraceuticals for Gut-Brain Axis Health: A Novel Approach to Combat Malnutrition and Future Personalised Nutraceutical Interventions.

    • 2025-04-30
    • Review
    • Nutrients 17(9)
    • • Litai Liu
      • Wen Qi
      • Na Zhang
      • Jinhao Zhang
      • Shen Liu
      • Huan Wang
      • Lianzhou Jiang
      • Ying Sun

    • PubMed: 40362863
    • DOI: 10.3390/nu17091551

    5 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Intestinal Inflammation
    • Improved Gastrointestinal Symptoms
    • Improved Psychological Well-being
    • Improved Gastrointestinal Discomfort

    • Moderate evidence
    • Rigorous Journal

  • Probiotic, Prebiotic, and Synbiotic Supplementation for the Prevention and Treatment of Acute Otitis Media: A Systematic Review and Meta-Analysis.

    • 2025-04-30
    • Review · n = 4,034
    • Children (Basel, Switzerland) 12(5)
    • • Freiser Eceomo Cruz Mosquera
      • Mayerli de la Rosa Caldas
      • Anisbed Naranjo Rojas
      • Claudia Lorena Perlaza
      • Yamil Liscano

    • PubMed: 40426770
    • DOI: 10.3390/children12050591

    1 Insight on

    • Reduced Acute Otitis Media

    • High evidence

  • Adding Lemon and n-3 PUFA-Rich Oil to Tomato Juice Preload to a Carbohydrate Meal Ameliorates Early Glycemic and Insulin Responses in Young Healthy Women: A Randomized Crossover Trial.

    • 2025-04-30
    • RCT · n = 21
    • Journal of nutritional science and vitaminology 71(2)
    • • Yuki Higuchi
      • Shizuo Kajiyama
      • Kaoru Kitta
      • Takashi Miyawaki
      • Shinya Matsumoto
      • Neiko Ozasa
      • Shintaro Kajiyama
      • Yoshitaka Hashimoto
      • Michiaki Fukui
      • Saeko Imai

    • PubMed: 40301054
    • DOI: 10.3177/jnsv.71.133

    1 Insight on

    • Reduced Postprandial Blood Glucose

    • High evidence

  • The Influences of Oral Probiotics on the Immunometabolic Response During Pregnancy and Lactation: A Systematic Review.

    • 2025-04-30
    • Systematic Review · n = 44
    • Nutrients 17(9)
    • • Valentin Nicolae Varlas
      • Laurențiu-Camil Bohîlțea
      • Nicolae Suciu

    • PubMed: 40362845
    • DOI: 10.3390/nu17091535

    8 Insights on

    • Reduced Weight Gain
    • Improved Homeostasis
    • Improved Immune Modulation
    • Reduced Prevalence of Gestational Diabetes Mellitus
    • Reduced Allergic Diseases
    • Modulated Maternal Immune Response
    • Reduced Risk of Preeclampsia
    • Reduced Infant Atopic Eczema and Allergic Disease

    • High evidence
    • Rigorous Journal

  • A Systematic Review of the Effects of Probiotics and Synbiotics on Infection Incidence after Liver Transplant Surgery.

    • 2025-04-30
    • Systematic Review
    • Preventive nutrition and food science 30(2)
    • • Barbod Alhouei
      • Ghazaleh Eslamian
      • Mahshad Mohtadi

    • PubMed: 40352302
    • DOI: 10.3746/pnf.2025.30.2.101

    3 Insights on

    • Reduced Postoperative Infectious Complications
    • Reduced Length of Hospital Stay
    • Reduced Duration of Antibiotic Usage

    • High evidence

  • Effect of Probiotic Streptococcus salivarius K12 Application on Palatal Wound Healing: An in Vivo Study.

    • 2025-04-30
    • RCT
    • The Malaysian journal of medical sciences : MJMS 32(2)
    • • Nissia Ananda
      • Dwi Ariawan
      • Vera Julia
      • Vetnizah Juniantito
      • Kania Alishaputri Wibisono
      • Endang Winiati Bachtiar

    • PubMed: 41079477
    • DOI: 10.21315/mjms-09-2024-657

    2 Insights on

    • Improved Wound Healing
    • Increased Inflammatory Cell Counts

    • High evidence
• Undated – 5 supplement studies

  • Bifidobacterium bifidum postbiotics prevent Salmonella Pullorum infection in chickens by modulating pyroptosis and enhancing gut health.

    • 2025-04
    • Clinical Trial
    • Poultry science 104(4)
    • • Yuhao Chen
      • Fuqiang Zhu
      • Guobi Yu
      • Nana Peng
      • Xinying Li
      • Meng Ge
      • Lei Yang
      • Wei Dong

    • PubMed: 40043668
    • DOI: 10.1016/j.psj.2025.104968

    2 Insights on

    • Improved Intestinal Barrier Function
    • Improved Gut Microbiota Balance

    • Low evidence
    • Animal Study

  • Effects of Lactobacillus curvatus SQ-425 and Staphylococcus simulans 65-4 as starter cultures on sensory characteristics, microbial communities and metabolites in fermented sausage.

    • 2025-04
    • Food research international (Ottawa, Ont.) 206
    • • Jiale Zheng
      • Zhanjun Wang
      • Sen Xiang
      • Zhongfang Tan
      • Guofang Wu
      • Jianbo Zhang
      • Xuan Luo
      • Lei Wang
      • Haiying Wang

    • PubMed: 40058898
    • DOI: 10.1016/j.foodres.2025.116030

    1 Insight on

    • Reduced Microbial Spoilage

    • Low evidence

  • Comparative study of photodynamic therapy with LED and probiotics in the treatment of halitosis: protocol for a randomised controlled clinical trial.

    • 2025-04
    • RCT · n = 92
    • BMJ open 15(4)
    • • Amanda Rafaelly Honório Mandetta
      • Juliana Maria Altavista Sagretti Gallo
      • Caroline Diniz Pagani Vieira Ribeiro
      • Marcela Letícia Leal Gonçalves
      • Ana Paula Taboada Sobral
      • Lara Jansiski Motta
      • Anna Carolina Ratto Tempestini Horliana
      • Raquel Agnelli Mesquita-Ferrari
      • Valherya Silva Rodriguez
      • Renato Araujo Prates
      • Cinthya Cosme Gutierrez Duran
      • Kristianne Porta Santos Fernandes
      • Sandra Kalil Bussadori

    • PubMed: 40280606
    • DOI: 10.1136/bmjopen-2024-095544

    1 Insight on

    • Reduced Halitosis

    • High evidence

  • Folic acid supplementation in children with sickle cell disease: a randomized double-blind noninferiority cross-over trial.

    • 2025-04
    • RCT · n = 31
    • The American journal of clinical nutrition 121(4)
    • • Brock A Williams
      • Heather McCartney
      • Joel Singer
      • Angela M Devlin
      • Suzanne Vercauteren
      • Ali Amid
      • John K Wu
      • Crystal D Karakochuk

    • PubMed: 39921095
    • DOI: 10.1016/j.ajcnut.2025.02.001

    2 Insights on

    • Reduced Red Blood Cell Folate Concentration
    • Reduced Folate Deficiency

    • High evidence

  • Short-Term Effects of Folate Supplementation in Combination With Vitamin B6 for Treating Acute Manic Episodes in Bipolar I Disorder: A Randomized Controlled Trial.

    • 2025-04
    • RCT · n = 43
    • Brain and behavior 15(4)
    • • Farzad Akbarzadeh
      • Andisheh Talaei
      • Mohsen Nematy
      • Dina Ganji
      • Alireza Ebrahimi
      • Ali Talaei

    • PubMed: 40200764
    • DOI: 10.1002/brb3.70432

    2 Insights on

    • Improved Recovery Rate
    • Reduced Mania Symptoms

    • High evidence