October 2022 Supplement Research Papers

• October 1

  • Hepatoprotective effect of combination of L-carnitine and magnesium-hydroxide in nonalcoholic fatty liver disease patients: a double-blinded randomized controlled pilot study.

    • 2022-10-01
    • RCT
    • European review for medical and pharmacological sciences 26(20)
    • • R Hazzan
      • N Abu Ahmad
      • W Slim
      • E Mazen
      • Z Neeman

    • PubMed: 36314323
    • DOI: 10.26355/eurrev_202210_30023

    6 Insights on

    • Improved Insulin Levels
    • Reduced C-Reactive Protein Levels
    • Improved Blood Lipid Profile
    • Reduced Alanine Aminotransferase Level
    • Reduced Aspartate Aminotransferase Level
    • Reduced Liver Stiffness

    • High evidence

  • LIVER INJURY INDUCED BY HERBAL AND DIETARY SUPPLEMENTS: A POOLED ANALYSIS OF CASE REPORTS.

    • 2022-10-01
    • Review
    • Arquivos de gastroenterologia 59(4)
    • • Michelle Hoff de Assis
      • Bruna Cherubini Alves
      • Vivian Cristine Luft
      • Valesca Dall'alba

    • PubMed: 36515339
    • DOI: 10.1590/s0004-2803.202204000-84

    4 Insights on

    • Reduced Hospitalization Requirement
    • Reduced Death Rate
    • Reduced Liver Transplantation Requirement
    • Reduced Chronic Liver Disease Severity

    • Low evidence
• October 3

  • Review of Evidence for the Usage of Antioxidants for Eye Aging.

    • 2022-10-03
    • Review
    • BioMed research international 2022
    • • Priscilla Peixi Choo
      • Pui Juan Woi
      • Mae-Lynn Catherine Bastion
      • Rokiah Omar
      • Mushawiahti Mustapha
      • Norshamsiah Md Din

    • PubMed: 36225983
    • DOI: 10.1155/2022/5810373

    4 Insights on

    • Relieved Intestinal Impairments
    • Reduced Intraocular Pressure
    • Prevented Retina Impairment
    • Alleviated Dry Eye Disease Symptoms

    • Low evidence

  • Integrated genome-based assessment of safety and probiotic characteristics of Lactiplantibacillus plantarum PMO 08 isolated from kimchi

    • 2022-10-03
    • PLOS ONE 17(10)
    • • Y. Oh
      • Seul-Ah Kim
      • Soo Hwi Yang
      • D. H. Kim
      • Yanwei Cheng
      • Jung Il Kang
      • Sang yun Lee
      • N. Han

    • PubMed: 36190947
    • DOI: 10.1371/journal.pone.0273986

    2 Insights on

    • Reduced Total Cholesterol Levels
    • Reduced Inflammation Levels

    • Low evidence
    • Rigorous Journal

  • Usefulness of Bifidobacterium longum BB536 in Elderly Individuals With Chronic Constipation: A Randomized Controlled Trial

    • 2022-10-03
    • RCT · n = 80
    • American Journal of Gastroenterology 118(3)
    • • T. Takeda
      • D. Asaoka
      • S. Nojiri
      • N. Yanagisawa
      • Yuji Nishizaki
      • T. Osada
      • S. Koido
      • A. Nagahara
      • N. Katsumata
      • T. Odamaki
      • Jinzhong Xiao
      • T. Ohkusa
      • Nobuhiro Sato

    • PubMed: 36216361
    • DOI: 10.14309/ajg.0000000000002028

    7 Insights on

    • Improved Bowel Movement Frequency
    • Improved Bowel Function
    • Safety of Probiotic Supplementation
    • Improved Constipation
    • Increased Stool Frequency
    • Improved Stool Frequency
    • Improved Evacuation

    • High evidence
• October 4

  • Comparison of two probiotics in follow-on formula: Bifidobacterium animalis subsp. lactis HN019 reduced upper respiratory tract infections in Chinese infants.

    • 2022-10-04
    • RCT · n = 192
    • Beneficial microbes 13(4)
    • • J Dekker
      • M Quilter
      • H Qian

    • PubMed: 36004715
    • DOI: 10.3920/bm2022.0041

    8 Insights on

    • Improved Stool Consistency
    • Reduced Hospitalization Rate
    • Reduced Upper Respiratory Infections
    • Improved Growth in Infants
    • Improved Stool Frequency
    • Reduced Upper Respiratory Tract Infection Episode
    • Reduced Antibiotic or Antiviral Prescription
    • Improved Temperament

    • High evidence
    • Large Human Trial
    • Rigorous Journal

  • Comparison of two probiotics in follow-on formula: Bifidobacterium animalis subsp. lactis HN019 reduced upper respiratory tract infections in Chinese infants.

    • 2022-10-04
    • RCT · n = 192
    • Beneficial Microbes 13(4)
    • • J. Dekker
      • M. Quilter
      • H. Qian

    • PubMed: 36004715
    • DOI: 10.3920/BM2022.0041

    5 Insights on

    • Reduced Upper Respiratory Infections
    • Reduced Incidence of Upper Respiratory Tract Infections
    • Reduced Antibiotic and Antiviral Use
    • Reduced Need for Antimicrobial Treatments
    • Reduced Antimicrobial Use

    • High evidence

  • Rotavirus immunisation status affects the efficacy of Lacticaseibacillus rhamnosus GG for the treatment of children with acute diarrhoea: a meta-analysis.

    • 2022-10-04
    • Meta-Analysis
    • Beneficial Microbes 13(4)
    • • A. Vecchio
      • F. Nunziata
      • D. Bruzzese
      • M. L. Conelli
      • A. Guarino

    • PubMed: 36004717
    • DOI: 10.3920/BM2022.0024

    2 Insights on

    • Reduced Duration of Diarrhea
    • Reduced Risk of Diarrhea

    • High evidence

  • Bacillus clausii UBBC-07 in the symptom management of upper respiratory tract infections in children: a double blind, placebo-controlled randomised study.

    • 2022-10-04
    • RCT · n = 90
    • Beneficial Microbes 13(4)
    • • R. Madempudi
      • J. Neelamraju
      • J. Ahire
      • M. Muthukumar
      • S. Rudrappa
      • G. Gopal
      • K. Nagendra

    • PubMed: 36004716
    • DOI: 10.3920/BM2021.0187

    5 Insights on

    • Reduced Upper Respiratory Infections
    • Increased Salivary sIgA Levels
    • Increased Salivary IgA Levels
    • Reduced Severity of URTIs
    • Reduced IgE Levels

    • High evidence
• October 5

  • Postbiotics: Current Trends in Food and Pharmaceutical Industry.

    • 2022-10-05
    • Review
    • Foods (Basel, Switzerland) 11(19)
    • • Priyamvada Thorakkattu
      • Anandu Chandra Khanashyam
      • Kartik Shah
      • Karthik Sajith Babu
      • Anjaly Shanker Mundanat
      • Aiswariya Deliephan
      • Gitanjali S Deokar
      • Chalat Santivarangkna
      • Nilesh Prakash Nirmal

    • PubMed: 36230169
    • DOI: 10.3390/foods11193094

    1 Insight on

    • Improved Intestinal Health

    • Moderate evidence
    • Highly Cited

  • The effects of fenugreek seed extract supplementation in patients with Alzheimer's disease: A randomized, double-blind, placebo-controlled trial.

    • 2022-10-05
    • RCT
    • Phytotherapy research : PTR 37(1)
    • • Elaheh Foroumandi
      • Roghayeh Javan
      • Leili Moayed
      • Hossein Fahimi
      • Fereshteh Kheirabadi
      • Mahboubeh Neamatshahi
      • Fazeleh Shogofteh
      • Azam Zarghi

    • PubMed: 36199177
    • DOI: 10.1002/ptr.7612

    7 Insights on

    • Reduced Diastolic Blood Pressure
    • Improved Quality of Life
    • Reduced Systolic Blood Pressure
    • Improved Memory Function
    • Increased Total Serum Antioxidant Capacity
    • Reduced Malondialdehyde Level
    • Reduced Depression

    • High evidence

  • The antidiabetic effects of Bifidobacterium longum subsp. longum BL21 through regulating gut microbiota structure in type 2 diabetic mice.

    • 2022-10-05
    • Clinical Trial
    • Food & Function 13(19)
    • • Junyu Hao
      • Yongli Zhang
      • Tao Wu
      • R. Liu
      • Wenjie Sui
      • Jiangu Zhu
      • S. Fang
      • Jieting Geng
      • M. Zhang

    • PubMed: 36056711
    • DOI: 10.1039/d2fo01109c

    7 Insights on

    • Improved Insulin Sensitivity
    • Improved Intestinal Barrier Function
    • Improved Intestinal Microflora Balance
    • Enhanced Antioxidant Capacity
    • Reduced Fasting Blood Glucose Levels
    • Increased Hepatic Glycogen Storage
    • Improved Endotoxemia-related Inflammation

    • Low evidence
    • Animal Study
• October 6

  • Two Gold Kiwifruit Daily for Effective Treatment of Constipation in Adults-A Randomized Clinical Trial.

    • 2022-10-06
    • RCT
    • Nutrients 14(19)
    • • Simone B Bayer
      • Phoebe Heenan
      • Chris Frampton
      • Catherine L Wall
      • Lynley N Drummond
      • Nicole C Roy
      • Richard B Gearry

    • PubMed: 36235798
    • DOI: 10.3390/nu14194146

    3 Insights on

    • Improved Bowel Movement Frequency
    • Reduced Straining
    • Improved Constipation Symptoms

    • High evidence
    • Rigorous Journal

  • Breast microecology improvement using probiotics following needle aspiration in patients with lactational breast abscess: a multi-center randomized double-blind controlled trial.

    • 2022-10-06
    • RCT · n = 51
    • Scientific reports 12(1)
    • • Yi Zhang
      • Yajun Gao
      • Jing Qin
      • Xiaoting Li
      • Fei Jiang
      • Yuanxuan Cai
      • Hui Feng
      • Xidong Gu
      • Mingze Gao
      • Lijuan Wang
      • Yiqi Lin
      • Yingyi Fan
      • Bucun Xu
      • Enli Wang
      • Qing Shao

    • PubMed: 36202884
    • DOI: 10.1038/s41598-022-20756-w

    3 Insights on

    • Reduced Pain
    • Improved Abscess Cure Rate
    • Maintained Breastfeeding Continuation

    • High evidence
    • Rigorous Journal
• October 9

  • Effect of Casein Hydrolysate on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    • 2022-10-09
    • Meta-Analysis
    • Nutrients 14(19)
    • • Shuaishuai Zhou
      • Teng Xu
      • Xu Zhang
      • Junjie Luo
      • Peng An
      • Yongting Luo

    • PubMed: 36235859
    • DOI: 10.3390/nu14194207

    7 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure
    • Increased HDL Cholesterol Levels
    • Increased Blood Glucose Levels
    • Maintained Total Cholesterol Level
    • Did Not Change Low-Density Lipoprotein Level
    • No Change in Triglyceride Level

    • High evidence
    • Rigorous Journal
• October 10

  • Clinical outcomes following pre-, pro- and synbiotic supplementation after caesarean birth or antibiotic exposure in the first week of life in term born infants: A systematic review of the literature

    • 2022-10-10
    • Systematic Review
    • Frontiers in Pediatrics 10
    • • K. Kamphorst
      • Nora C Carpay
      • T. D. de Meij
      • J. Daams
      • R. V. van Elburg
      • A. Vlieger

    • PubMed: 36299694
    • DOI: 10.3389/fped.2022.974608

    4 Insights on

    • Reduced Incidence of Common Infectious Diseases
    • Reduced Infant Colics
    • Reduced Atopic Diseases
    • Decreased Immune Response to Influenza Vaccination

    • High evidence
• October 11

  • Synbiotic Intervention with Lactobacilli, Bifidobacteria, and Inulin in Healthy Volunteers Increases the Abundance of Bifidobacteria but Does Not Alter Microbial Diversity.

    • 2022-10-11
    • Clinical Trial · n = 12
    • Applied and environmental microbiology 88(19)
    • • Ingrid Maria Cecilia Rubin
      • Sarah Mollerup
      • Christa Broholm
      • Adam Baker
      • Mona Katrine Alberthe Holm
      • Martin Schou Pedersen
      • Mette Pinholt
      • Henrik Westh
      • Andreas Munk Petersen

    • PubMed: 36165644
    • DOI: 10.1128/aem.01087-22

    3 Insights on

    • Increased Fecal Probiotic Strains
    • No Change in Microbial Diversity
    • Unchanged Stool Consistency or Bowel Frequency

    • High evidence
    • Rigorous Journal

  • The efficacy and safety of St. John's wort extract in depression therapy compared to SSRIs in adults: A meta-analysis of randomized clinical trials.

    • 2022-10-11
    • Meta-Analysis · n = 2,270
    • Advances in clinical and experimental medicine : official organ Wroclaw Medical University 32(2)
    • • Xin Zhao
      • Hong Zhang
      • Yanyan Wu
      • Chun Yu

    • PubMed: 36226689
    • DOI: 10.17219/acem/152942

    2 Insights on

    • Reduced Depressive Symptom
    • Reduced Hamilton Depression Rating Scale Score

    • High evidence

  • Effect of Microencapsulation Techniques on the Stress Resistance and Biological Activity of Bovine Lactoferricin-Lactoferrampin-Encoding Lactobacillus reuteri.

    • 2022-10-11
    • Foods (Basel, Switzerland) 11(20)
    • • Xueying Wang
      • Weichun Xie
      • Senhao Zhang
      • Yilan Shao
      • Jiyao Cai
      • Limeng Cai
      • Xiaona Wang
      • Zhifu Shan
      • Han Zhou
      • Jiaxuan Li
      • Wen Cui
      • Li Wang
      • Xinyuan Qiao
      • Yijing Li
      • Yanping Jiang
      • Lijie Tang

    • PubMed: 37430918
    • DOI: 10.3390/foods11203169

    2 Insights on

    • Improved Gut Microbiota
    • Improved Probiotic Product Stability

    • Low evidence
• October 13

  • A newly developed strain of Enterococcus faecium isolated from fresh dairy products to be used as a probiotic in lactating Holstein cows

    • 2022-10-13
    • RCT
    • Frontiers in Veterinary Science 9
    • • H. Azzaz
      • A. Kholif
      • H. Murad
      • Einar Vargas-Bello-Pérez

    • PubMed: 36311649
    • DOI: 10.3389/fvets.2022.989606

    5 Insights on

    • Improved Blood Glucose Levels
    • Reduced Serum Total Cholesterol Levels
    • Increased Milk Production
    • Improved Digestive Function
    • Reduced Methane Production

    • High evidence
• October 14

  • Probiotics in the Prevention and Treatment of Gestational Diabetes Mellitus (GDM): A Review.

    • 2022-10-14
    • Review
    • Nutrients 14(20)
    • • Klaudia Kamińska
      • Dominika Stenclik
      • Wiktoria Błażejewska
      • Paweł Bogdański
      • Małgorzata Moszak

    • PubMed: 36296986
    • DOI: 10.3390/nu14204303

    1 Insight on

    • Improved Glycemia

    • Moderate evidence
    • Rigorous Journal

  • Effects of Lactiplantibacillus plantarum OLL2712 on Memory Function in Older Adults with Declining Memory: A Randomized Placebo-Controlled Trial

    • 2022-10-14
    • RCT · n = 78
    • Nutrients 14(20)
    • • Keisuke Sakurai
      • T. Toshimitsu
      • Erika Okada
      • Saya Anzai
      • Izumi Shiraishi
      • Noriko Inamura
      • Satoru Kobayashi
      • T. Sashihara
      • T. Hisatsune

    • PubMed: 36296983
    • DOI: 10.3390/nu14204300

    1 Insight on

    • Improved Memory Function

    • High evidence

  • Importance of Intermittent Fasting Regimens and Selection of Adequate Therapy on Inflammation and Oxidative Stress in SARS-CoV-2 Infection.

    • 2022-10-14
    • Review
    • Nutrients 14(20)
    • • Armin Ezzati
      • Sara K Rosenkranz
      • Benjamin D Horne

    • PubMed: 36296982
    • DOI: 10.3390/nu14204299

    1 Insight on

    • Reduced Inflammatory Biomarker Level

    • Moderate evidence
    • Rigorous Journal
• October 18

  • Piper longum L.: A comprehensive review on traditional uses, phytochemistry, pharmacology, and health‐promoting activities

    • 2022-10-18
    • Review
    • Phytotherapy Research 36(12)
    • • P. Biswas
      • Mimosa Ghorai
      • Tulika Mishra
      • A. Gopalakrishnan
      • Debleena Roy
      • A. Mane
      • A. Mundhra
      • N. Das
      • V. M. Mohture
      • M. Patil
      • Md. Habibur Rahman
      • N. Jha
      • G. Batiha
      • S. Saha
      • M. Shekhawat
      • Radha
      • M. Kumar
      • D. Pandey
      • A. Dey

    • PubMed: 36256521
    • DOI: 10.1002/ptr.7649

    19 Insights on

    • Increased Antioxidant Activity
    • Improved Liver Function
    • Reduced Pathogenic Load
    • Improved Immunomodulation
    • Enhanced Antimicrobial Resistance
    • Increased Anticancer Activity
    • Reduced Pain Intensity
    • Reduced Inflammatory Cell Activity
    • Reduced Lipid Levels
    • Reduced Glucose Levels
    • Reduced Helminth Infection
    • Reduced Mosquito Population
    • Enhanced Neuropharmacological Function
    • Increased Antiangiogenic Activity
    • Reduced Arthritis Symptoms
    • Reduced Ulcer Symptoms
    • Improved Asthmatic Condition
    • Improved Cardioprotective Activity
    • Increased Anti-Venom Efficacy

    • Low evidence
• October 19

  • One-year supplementation with Lactobacillus reuteri ATCC PTA 6475 counteracts a degradation of gut microbiota in older women with low bone mineral density.

    • 2022-10-19
    • RCT · n = 20
    • NPJ biofilms and microbiomes 8(1)
    • • Peishun Li
      • Boyang Ji
      • Hao Luo
      • Daniel Sundh
      • Mattias Lorentzon
      • Jens Nielsen

    • PubMed: 36261538
    • DOI: 10.1038/s41522-022-00348-2

    4 Insights on

    • Improved Gut Microbiota Diversity
    • Reduced Enterotoxigenic Escherichia coli Abundance
    • Reduced Gut Inflammation
    • Reduced Bone Loss

    • High evidence

  • Lactiplantibacillus plantarum 299v supplementation modulates β-cell ER stress and antioxidative defense pathways and prevents type 1 diabetes in gluten-free BioBreeding rats

    • 2022-10-19
    • Clinical Trial
    • Gut Microbes 14(1)
    • • Pinar Sargin
      • Mark F. Roethle
      • S. Jia
      • Tarun Pant
      • Ashley E. Ciecko
      • Samantha Atkinson
      • N. Salzman
      • R. Teng
      • Yi-Guang Chen
      • S. Cabrera
      • M. Hessner

    • PubMed: 36261888
    • DOI: 10.1080/19490976.2022.2136467

    4 Insights on

    • Improved Stress Response
    • Enhanced Antioxidant Defense
    • Delayed Onset of Type 1 Diabetes
    • Reduced ER Stress Responses in β-cells

    • Low evidence
    • Rigorous Journal
    • Animal Study
• October 20

  • Effects of L-Citrulline Supplementation on Endothelial Function and Blood Pressure in Hypertensive Postmenopausal Women.

    • 2022-10-20
    • RCT
    • Nutrients 14(20)
    • • Arun Maharaj
      • Stephen M Fischer
      • Katherine N Dillon
      • Yejin Kang
      • Mauricio A Martinez
      • Arturo Figueroa

    • PubMed: 36297080
    • DOI: 10.3390/nu14204396

    5 Insights on

    • Reduced Diastolic Blood Pressure
    • Improved Vascular Endothelial Function
    • Reduced Mean Arterial Pressure
    • Increased Flow-Mediated Dilation
    • Reduced Aortic Stiffness

    • High evidence
    • Rigorous Journal

  • The Probiotic Strains Bifidοbacterium lactis, Lactobacillus acidophilus, Lactiplantibacillus plantarum and Saccharomyces boulardii Regulate Wound Healing and Chemokine Responses in Human Intestinal Subepithelial Myofibroblasts

    • 2022-10-20
    • Pharmaceuticals 15(10)
    • • G. Tarapatzi
      • E. Filidou
      • L. Kandilogiannakis
      • M. Spathakis
      • Maria Gaitanidou
      • K. Arvanitidis
      • I. Drygiannakis
      • V. Valatas
      • K. Kotzampassi
      • V. Manolopoulos
      • G. Kolios
      • S. Vradelis

    • PubMed: 36297405
    • DOI: 10.3390/ph15101293

    2 Insights on

    • Altered Chemokine Response
    • Improved Wound Healing

    • Low evidence

  • Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.

    • 2022-10-20
    • RCT
    • Nutritional neuroscience 26(11)
    • • Tharaka L Dassanayake
      • Devasmitha Wijesundara
      • Chanaka N Kahathuduwa
      • Vajira S Weerasinghe

    • PubMed: 36263942
    • DOI: 10.1080/1028415x.2022.2136884

    3 Insights on

    • Improved Visuomotor Speed
    • Improved Sustained Attention
    • Improved Inhibitory Control

    • High evidence
• October 21

  • Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications.

    • 2022-10-21
    • Review
    • Nature reviews. Gastroenterology & hepatology 20(5)
    • • Fen Zhang
      • Raphaela I Lau
      • Raphaela I Lau
      • Qin Liu
      • Qi Su
      • Francis K L Chan
      • Siew C Ng

    • PubMed: 36271144
    • DOI: 10.1038/s41575-022-00698-4

    2 Insights on

    • Modulated Gut Microbiota
    • Improved COVID-19 Disease Outcomes

    • Moderate evidence
    • Highly Cited

  • Role of Intestinal Microbes in Chronic Liver Diseases.

    • 2022-10-21
    • Review
    • International journal of molecular sciences 23(20)
    • • Mengyi Xu
      • Kangkang Luo
      • Junjie Li
      • Yu Li
      • Yuxuan Zhang
      • Zhiyao Yuan
      • Qiang Xu
      • Xudong Wu

    • PubMed: 36293518
    • DOI: 10.3390/ijms232012661

    3 Insights on

    • Improved Liver Function
    • Reduced Body Fat
    • Improved Bowel Habits

    • Moderate evidence
    • Rigorous Journal

  • Nutritional Health Perspective of Natto: A Critical Review

    • 2022-10-21
    • Biochemistry Research International 2022
    • • M. Afzaal
      • F. Saeed
      • Fakhar Islam
      • Huda Ateeq
      • Aasma Asghar
      • Yasir Abbas Shah
      • C. Ofoedu
      • James S. Chacha

    • PubMed: 36312453
    • DOI: 10.1155/2022/5863887

    1 Insight on

    • Increased Menaquinone-7 Levels

    • Low evidence

  • The probiotic Bacillus subtilis BS50 decreases gastrointestinal symptoms in healthy adults: a randomized, double-blind, placebo-controlled trial

    • 2022-10-21
    • RCT · n = 76
    • Gut Microbes 14(1)
    • • S. Garvey
      • E. Mah
      • Traci M. Blonquist
      • V. Kaden
      • Jessica L. Spears

    • PubMed: 36269141
    • DOI: 10.1080/19490976.2022.2122668

    3 Insights on

    • Reduced Bloating
    • Reduced Gastrointestinal Symptoms
    • Reduced Burping Frequency

    • High evidence
    • Rigorous Journal

  • The beneficial effects of Lacticaseibacillus casei on the small intestine and colon of Swiss mice against the deleterious effects of 5-fluorouracil

    • 2022-10-21
    • Clinical Trial
    • Frontiers in Immunology 13
    • • Stphannie Jamyla de Araújo Barbosa
      • Maisie Mitchele Barbosa Oliveira
      • S. B. Ribeiro
      • C. A. X. de Medeiros
      • Maria Laura de Souza Lima
      • G. C. B. Guerra
      • R. F. de Araújo Júnior
      • Francisco Canindé de Sousa Júnior
      • A. Martins
      • D. Paiva
      • Raphael Victor Silva Andrade
      • C. S. M. Rebouças
      • G. C. Brito
      • R. C. Leitão
      • A. A. de Araújo

    • PubMed: 36341441
    • DOI: 10.3389/fimmu.2022.954885

    6 Insights on

    • Improved Intestinal Barrier Function
    • Improved Immune Function
    • Reduced Inflammation Levels
    • Increased Skin Mucus Protein Levels
    • Reduced Inflammation
    • Increased Fecal Lactic Acid Bacteria Concentration

    • Low evidence
    • Animal Study
• October 25

  • Impact of red yeast rice supplementation on lipid profile: a systematic review and meta-analysis of randomized-controlled trials.

    • 2022-10-25
    • Meta-Analysis
    • Expert review of clinical pharmacology 16(1)
    • • Parisa Rahmani
      • Ebru Melekoglu
      • Sogand Tavakoli
      • Nasser Malekpour Alamdari
      • Pejman Rohani
      • Mohammad Hassan Sohouli

    • PubMed: 36259545
    • DOI: 10.1080/17512433.2023.2138342

    4 Insights on

    • Reduced Triglyceride Levels
    • Reduced LDL Cholesterol
    • Reduced Blood Cholesterol
    • Increased High-Density Lipoprotein Cholesterol

    • High evidence
• October 26

  • Persistence of the Probiotic Lacticaseibacillus rhamnosus Strain GG (LGG) in an In Vitro Model of the Gut Microbiome

    • 2022-10-26
    • International Journal of Molecular Sciences 23(21)
    • • Karley K. Mahalak
      • Jenni Firrman
      • J. Bobokalonov
      • Adrienne B. Narrowe
      • K. Bittinger
      • S. Daniel
      • C. Tanes
      • Lisa M. Mattei
      • Weizhen Zeng
      • J. Soares
      • M. Kobori
      • Johanna M. S. Lemons
      • P. Tomasula
      • L. Liu

    • PubMed: 36361763
    • DOI: 10.3390/ijms232112973

    1 Insight on

    • Improved Gastrointestinal Health

    • Low evidence
• October 27

  • Supplementation of Probiotics in Pregnant Women Targeting Group B Streptococcus Colonization: A Systematic Review and Meta-Analysis.

    • 2022-10-27
    • Meta-Analysis · n = 132
    • Nutrients 14(21)
    • • Daniela Menichini
      • Giuseppe Chiossi
      • Francesca Monari
      • Francesco De Seta
      • Fabio Facchinetti

    • PubMed: 36364782
    • DOI: 10.3390/nu14214520

    2 Insights on

    • Reduced Vaginal Group B Streptococcus Colonization
    • Improved Perinatal Safety

    • High evidence
    • Rigorous Journal
• October 28

  • Effects of probiotic supplementation on related side effects after chemoradiotherapy in cancer patients.

    • 2022-10-28
    • Meta-Analysis · n = 97
    • Frontiers in oncology 12
    • • Yongkai Lu
      • Xiaoqin Luo
      • Di Yang
      • Yi Li
      • Tuotuo Gong
      • Binglin Li
      • Jian Cheng
      • Ruijuan Chen
      • Xin Guo
      • Wei Yuan

    • PubMed: 36387216
    • DOI: 10.3389/fonc.2022.1032145

    3 Insights on

    • Reduced Diarrhea
    • Reduced Oral Mucositis Severity
    • Reduced Chemotherapy Side Effects

    • High evidence

  • Effects of oral administration of Bifidobacterium animalis subsp. lactis HN019 on the treatment of plaque-induced generalized gingivitis.

    • 2022-10-28
    • RCT · n = 30
    • Clinical oral investigations 27(1)
    • • Yara Loyanne de Almeida Silva Levi
      • Marcella Costa Ribeiro
      • Pedro Henrique Félix Silva
      • Giselle Aparecida Silva
      • Sergio Luiz de Souza Salvador
      • Sérgio Luís Scombatti de Souza
      • Renato Casarin
      • Arthur Belem Novaes Júnior
      • Mario Taba Júnior
      • Daniela Bazan Palioto
      • Heitor Marques Honório
      • Michel Reis Messora
      • Flávia Aparecida Chaves Furlaneto

    • PubMed: 36305963
    • DOI: 10.1007/s00784-022-04744-y

    6 Insights on

    • Reduced Pro-inflammatory Cytokine Levels
    • Improved Gingival Health
    • Reduced Formation of Dental Plaque
    • Reduced Bleeding on Probing (BOP)
    • Reduced Gingival Inflammation
    • Improved Disease Resolution

    • High evidence

  • Lacticaseibacillus rhamnosus HN001 alters the microbiota composition in the cecum but not the feces in a piglet model

    • 2022-10-28
    • Clinical Trial
    • Frontiers in Nutrition 9
    • • W. Young
      • P. Maclean
      • K. Dunstan
      • Leigh Ryan
      • J. Peters
      • K. Armstrong
      • R. Anderson
      • Hilary Dewhurst
      • Melanie van Gendt
      • R. Dilger
      • J. Dekker
      • N. Haggarty
      • N. Roy

    • PubMed: 36386940
    • DOI: 10.3389/fnut.2022.1002369

    3 Insights on

    • Improved Intestinal Barrier Function
    • Increased Prevotella Concentration
    • Reduced Methanobrevibacter Levels

    • Low evidence
    • Animal Study
• October 29

  • Effect of supplemental vitamin D3 on bone mineral density: a systematic review and meta-analysis.

    • 2022-10-29
    • Meta-Analysis
    • Nutrition reviews 81(5)
    • • Elham Kazemian
      • Ali Pourali
      • Fatemeh Sedaghat
      • Mehrdad Karimi
      • Vahid Basirat
      • Zohreh Sajadi Hezaveh
      • Sayed Hossein Davoodi
      • Michael F Holick

    • PubMed: 36308775
    • DOI: 10.1093/nutrit/nuac068

    2 Insights on

    • Improved Bone Mineral Density
    • Reduced Bone Mineral Density

    • High evidence

  • Microbial Communities of Artisanal Fermented Milk Products from Russia.

    • 2022-10-29
    • Observational
    • Microorganisms 10(11)
    • • Tatiana V Kochetkova
      • Ilya P Grabarnik
      • Alexandra A Klyukina
      • Kseniya S Zayulina
      • Ivan M Elizarov
      • Oksana O Shestakova
      • Liliya A Gavirova
      • Anastasia D Malysheva
      • Polina A Shcherbakova
      • Darima D Barkhutova
      • Olga V Karnachuk
      • Andrey I Shestakov
      • Alexander G Elcheninov
      • Ilya V Kublanov

    • PubMed: 36363732
    • DOI: 10.3390/microorganisms10112140

    1 Insight on

    • Microbial Community Characterization

    • Low evidence
• October 31

  • Influence of biotin intervention on glycemic control and lipid profile in patients with type 2 diabetes mellitus: A systematic review and meta-analysis.

    • 2022-10-31
    • Systematic Review · n = 445
    • Frontiers in nutrition 9
    • • Yujia Zhang
      • Yiwang Ding
      • Yawen Fan
      • Yenan Xu
      • Yuting Lu
      • Lingzi Zhai
      • Ling Wang

    • PubMed: 36386951
    • DOI: 10.3389/fnut.2022.1046800

    4 Insights on

    • Reduced Triglyceride Levels
    • Reduced Blood Cholesterol
    • Reduced Fasting Blood Glucose Levels
    • Unchanged Insulin Level

    • High evidence

  • Effects of Grape Seed Extract Supplementation on Endothelial Function and Endurance Performance in Basketball Players.

    • 2022-10-31
    • Clinical Trial
    • International journal of environmental research and public health 19(21)
    • • Hosung Nho
      • Kyung-Ae Kim

    • PubMed: 36361103
    • DOI: 10.3390/ijerph192114223

    2 Insights on

    • Improved Endurance
    • Improved Vascular Endothelial Function

    • High evidence
• Undated – 5 supplement studies

  • Effect of macular pigment carotenoids on cognitive functions: A systematic review.

    • 2022-10
    • Systematic Review
    • Physiology & behavior 254
    • • Marta-C García-Romera
      • María-Carmen Silva-Viguera
      • Inmaculada López-Izquierdo
      • Alfredo López-Muñoz
      • Raúl Capote-Puente
      • Beatriz Gargallo-Martínez

    • PubMed: 35752349
    • DOI: 10.1016/j.physbeh.2022.113891

    7 Insights on

    • Improved Cognitive Function
    • Improved Attention Span
    • Improved Memory Function
    • Improved Processing Speed
    • Increased Macular Pigment Optical Density
    • Improved Reasoning
    • Changed Brain Activity

    • High evidence

  • Acetyl-L-carnitine Slows the Progression from Prefrailty to Frailty in Older Subjects: A Randomized Interventional Clinical Trial.

    • 2022-10
    • RCT · n = 92
    • Current pharmaceutical design 28(38)
    • • Giulia Malaguarnera
      • Vito Emanuele Catania
      • Gaetano Bertino
      • Laura Maria Chisari
      • Maria Castorina
      • Claudia Bonfiglio
      • Omar Cauli
      • Michele Malaguarnera

    • PubMed: 36043711
    • DOI: 10.2174/1381612828666220830092815

    4 Insights on

    • Increased HDL Cholesterol Levels
    • Reduced C-Reactive Protein Levels
    • Improved Mini-Mental State Examination Score
    • Improved 6-minute Walking Distance

    • High evidence

  • Isolation, characterization and anti-UVB irradiation activity of an extracellular polysaccharide produced by Lacticaseibacillus rhamnosus VHPriobi O17.

    • 2022-10
    • Heliyon 8(10)
    • • Shudong Peng
      • Chaoqun Guo
      • Songjie Wu
      • Zhi Duan

    • PubMed: 36299523
    • DOI: 10.1016/j.heliyon.2022.e11125

    4 Insights on

    • Reduced Pro-inflammatory Cytokine Release
    • Reduced Oxidative Stress
    • Reduced Cell Apoptosis
    • Reduced UVB-Induced Skin Cell Damage

    • Low evidence

  • Effects of Bacillus coagulans GBI-30, 6086 as an adjunct starter culture on the production of yogurt.

    • 2022-10
    • Food research international (Ottawa, Ont.) 160
    • • Jiang Cao
      • Zhiming Yu
      • Qingsong Zhang
      • Leilei Yu
      • Jianxin Zhao
      • Hao Zhang
      • Wei Chen
      • Qixiao Zhai

    • PubMed: 36076366
    • DOI: 10.1016/j.foodres.2022.111398

    1 Insight on

    • Improved Survival of Probiotic Bacteria

    • Low evidence

  • Effects of milk protein concentrate supplementation on metabolic parameters, adipocytokines and body composition in obese women under weight-loss diet: study protocol for a randomised controlled trial.

    • 2022-10
    • RCT
    • BMJ open 12(10)
    • • Fatemeh Haidari
      • Mahsa Elahikhah
      • Sheikh Mohammed Shariful Islam
      • Majid Mohammadshahi
      • Hajieh Shahbazian
      • Vahideh Aghamohammadi

    • PubMed: 36202586
    • DOI: 10.1136/bmjopen-2022-064727

    8 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Reduced Uric Acid Levels
    • Increased Adiponectin Levels
    • Reduced Appetite
    • Improved Body Composition
    • Reduced Fasting Blood Glucose Levels
    • Improved Blood Lipid Profile

    • High evidence