February 2025 Supplement Research Papers

• February 1

  • Beneficial effects and possible mechanism of intake coffee for COVID-19: A meta-analysis and molecular docking.

    • 2025-02-01
    • Meta-Analysis · n = 290
    • Medicine 104(7)
    • • Yong-Zheng Fan
      • Yun-Li Duan
      • An-Na Zhang
      • Yu Wang

    • PubMed: 39960901
    • DOI: 10.1097/md.0000000000041550

    3 Insights on

    • Reduced COVID-19 Infection
    • Improved COVID-19 Recovery Rate
    • Increased Benefit Rate

    • High evidence

  • Effect of Selenomethionine- Enriched Yeast on Hypothyroidism Patients.

    • 2025-02-01
    • RCT · n = 40
    • Archives of Razi Institute 80(1)
    • • A Hajyasini
      • A Dehnad
      • A Farzi
      • M Mobasseri
      • A Ostadrahimi
      • B Kafili

    • PubMed: 40951555
    • DOI: 10.32592/ari.2025.80.1.257

    7 Insights on

    • Reduced Total Cholesterol Levels
    • Reduced Liver Enzyme Levels
    • Increased Hemoglobin Levels
    • Reduced Malondialdehyde Level
    • Reduced Anti-Thyroid Peroxidase Antibody Level
    • Reduced Catalase Activity
    • Reduced Thyroid Stimulating Hormone Level

    • High evidence
• February 3

  • Ginkgo biloba extract EGb 761 is safe and effective in the treatment of mild dementia - a meta-analysis of patient subgroups in randomised controlled trials.

    • 2025-02-03
    • Meta-Analysis · n = 782
    • The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 26(3)
    • • Matthias Riepe
      • Robert Hoerr
      • Sandra Schlaefke

    • PubMed: 39895346
    • DOI: 10.1080/15622975.2024.2446830

    4 Insights on

    • Improved Quality of Life
    • Improved Activities of Daily Living
    • Improved Cognition
    • Improved Global Assessment

    • High evidence

  • [Recommendations of the DGRh Committee on Complementary Medicine and Nutrition on the application of selected phytotherapeutic drugs and herbal medicines in rheumatology].

    • 2025-02-03
    • Review
    • Zeitschrift fur Rheumatologie 84(2)
    • • Gernot Keyßer
      • Olga Seifert
      • Inna Frohne
      • Andreas Michalsen
      • Alexander Pfeil
      • Monika Reuß-Borst
      • Oliver Sander

    • PubMed: 39900858
    • DOI: 10.1007/s00393-024-01612-w

    2 Insights on

    • Reduced Inflammation
    • Improved Symptom Control in Degenerative Joint Disease

    • Low evidence
• February 4

  • The effect of magnesium supplementation on serum concentration of lipid profile: an updated systematic review and dose-response meta-analysis on randomized controlled trials.

    • 2025-02-04
    • Meta-Analysis
    • Nutrition journal 24(1)
    • • Mitra Hariri
      • Masoudreza Sohrabi
      • Ali Gholami

    • PubMed: 39905454
    • DOI: 10.1186/s12937-025-01085-w

    1 Insight on

    • Increased HDL Cholesterol Levels

    • High evidence

  • Ligilactobacillus salivarius LZZAY01 accelerated autophagy and apoptosis in colon cancer cells and improved gut microbiota in CAC mice.

    • 2025-02-04
    • Microbiology spectrum 13(2)
    • • Wenhong Yang
      • Tao Li
      • Shixiang An
      • Rong Chen
      • Yuxin Zhao
      • Jiaxian Cui
      • Mingyu Zhang
      • Jingkun Lu
      • Yunpeng Tian
      • Lili Bao
      • Pengwei Zhao

    • PubMed: 39792005
    • DOI: 10.1128/spectrum.01861-24

    4 Insights on

    • Improved Gut Microbiota Composition
    • Improved Intestinal Barrier Function
    • Improved Gut Integrity
    • Reduced Inflammation

    • Low evidence

  • Evidence construction of Silibinin capsules against alcoholic liver disease based on a meta-analysis and systematic review.

    • 2025-02-04
    • Systematic Review · n = 221
    • Frontiers in pharmacology 16
    • • Yan Wang
      • Wenmin Yang
      • Yuan Yang
      • Xingning Liu
      • Lanfen Peng
      • Qi Huang
      • Kongli Fan
      • Rui Hu
      • Jinyu Yi
      • Xin Zhong
      • Jing Li
      • Jialing Sun
      • Xiaozhou Zhou

    • PubMed: 39968181
    • DOI: 10.3389/fphar.2025.1516204

    9 Insights on

    • Reduced Triglyceride Levels
    • Reduced Blood Cholesterol
    • Reduced Gamma-Glutamyl Transferase Levels
    • Reduced Alanine Aminotransferase Level
    • Reduced Total Bilirubin Level
    • Reduced Aspartate Aminotransferase Level
    • Reduced Prothrombin Time
    • Reduced Type III Procollagen
    • Improved Effective Rate

    • High evidence
• February 5

  • Microbiota modifications in prehabilitation - the next step towards comprehensive preparation for surgery. The scoping review.

    • 2025-02-05
    • Review
    • Przeglad gastroenterologiczny 19(4)
    • • Igor Łoniewski
      • Tomasz Banasiewicz
      • Jerzy Sieńko
      • Karolina Skonieczna-Zydecka
      • Ewa Stachowska

    • PubMed: 39810873
    • DOI: 10.5114/pg.2024.145833

    5 Insights on

    • Improved Immune Response
    • Reduced Total Infections
    • Improved Recovery Rate
    • Reduced Recovery Time After Surgery
    • Reduced Postoperative Recovery Time

    • Low evidence
• February 6

  • Efficacy of probiotic supplements in the treatment of sarcopenia: A systematic review and meta-analysis.

    • 2025-02-06
    • Meta-Analysis · n = 22
    • PloS one 20(2)
    • • Yi Wang
      • Ping Lei

    • PubMed: 39913546
    • DOI: 10.1371/journal.pone.0317699

    3 Insights on

    • Improved Muscle Strength
    • No Significant Change in Muscle Mass
    • No Significant Change in Lean Body Mass

    • High evidence

  • Advancements related to probiotics for preventing and treating recurrent respiratory tract infections in children.

    • 2025-02-06
    • Review
    • Frontiers in pediatrics 13
    • • Yali Zhang
      • Yingying Xu
      • Ling Hu
      • Xiaomei Wang

    • PubMed: 39981209
    • DOI: 10.3389/fped.2025.1508613

    2 Insights on

    • Reduced Upper Respiratory Infections
    • Reduced Antibiotic Use

    • Low evidence

  • Effect of Microencapsulated Medium-Chain Fatty Acids, Lignocellulose, and Heat-Killed Lactobacillus plantarum L-137 Supplementation on Lactating Sow Performance, and Nutritional and Immunological Parameters in Colostrum.

    • 2025-02-06
    • RCT
    • Veterinary sciences 12(2)
    • • Nithat Wichasit
      • Wandee Tartrakoon
      • Rangsun Charoensook
      • Riantong Singanusong
      • Juan J Loor
      • Gaku Shoji
      • Satoru Onoda
      • Tossaporn Incharoen

    • PubMed: 40005894
    • DOI: 10.3390/vetsci12020134

    2 Insights on

    • Improved Immune Parameters
    • Improved Lactation Performance

    • High evidence
• February 7

  • Effect of N-Acetyl Cysteine as an Adjuvant Treatment in Alzheimer's Disease.

    • 2025-02-07
    • Review
    • Brain sciences 15(2)
    • • Sarah Monserrat Lomelí Martínez
      • Fermín Paul Pacheco Moisés
      • Oscar Kurt Bitzer-Quintero
      • Javier Ramírez-Jirano
      • Daniela L C Delgado-Lara
      • Irán Cortés Trujillo
      • Juan Heriberto Torres Jasso
      • Joel Salazar-Flores
      • Erandis Dheni Torres-Sánchez

    • PubMed: 40002497
    • DOI: 10.3390/brainsci15020164

    1 Insight on

    • Improved Cognitive Function

    • Low evidence

  • Evaluating the effects of seed oils on lipid profile, inflammatory and oxidative markers, and glycemic control of diabetic and dyslipidemic patients: a systematic review of clinical studies.

    • 2025-02-07
    • Systematic Review
    • Frontiers in nutrition 12
    • • Lucas Fornari Laurindo
      • Lívia Fornari Laurindo
      • Victória Dogani Rodrigues
      • Jéssica da Silva Camarinha Oliveira
      • Beatriz Leme Boaro
      • Adriano Cressoni Araújo
      • Elen Landgraf Guiguer
      • Claudia Rucco Penteado Detregiachi
      • Virgínia Maria Cavallari Strozze Catharin
      • Eduardo Federighi Baisi Chagas
      • Vitor Cavallari Strozze Catharin
      • Rosa Direito
      • Sandra Maria Barbalho

    • PubMed: 39996006
    • DOI: 10.3389/fnut.2025.1502815

    3 Insights on

    • Improved Blood Lipid Profile
    • Improved Glycemia
    • Reduced Oxidative Stress Marker Level

    • High evidence
• February 8

  • Supplementation with the Postbiotic BPL1™-HT (Heat-Inactivated Bifidobacterium animalis subsp. Lactis) Attenuates the Cardiovascular Alterations Induced by Angiotensin II Infusion in Mice.

    • 2025-02-08
    • Antioxidants (Basel, Switzerland) 14(2)
    • • Mario de la Fuente-Muñoz
      • Marta Román-Carmena
      • Sara Amor
      • Daniel González-Hedström
      • Verónica Martinez-Rios
      • Patricia Martorell
      • Antonio M Inarejos-García
      • Reme García Bou
      • Sonia Guilera-Bermell
      • Ángel L García-Villalón
      • Miriam Granado

    • PubMed: 40002381
    • DOI: 10.3390/antiox14020193

    5 Insights on

    • Reduced Blood Pressure
    • Reduced Inflammation
    • Reduced Oxidative Stress
    • Improved Vascular Endothelial Function
    • Improved Cardiac Function

    • Low evidence

  • Modulatory Effects of Multi-species/Multi-strain Synbiotic and L-carnitine Concomitant Supplementation on Atherogenic-Indices, Body Composition, Visceral Obesity, and Appetite in Metabolically Healthy Women with Obesity: A Double-Blind Randomized Controlled Clinical Trial.

    • 2025-02-08
    • RCT
    • Probiotics and antimicrobial proteins 17(6)
    • • Farnoush Fallah
      • Reza Mahdavi

    • PubMed: 39921845
    • DOI: 10.1007/s12602-025-10460-2

    12 Insights on

    • Reduced Visceral Fat
    • Reduced Waist-to-Height Ratio
    • Reduced Systolic Blood Pressure
    • Reduced Body Fat Percentage
    • Reduced Atherogenic Index
    • Reduced Fat Mass
    • Reduced Adiposity Index
    • Reduced Castelli Risk Index I
    • Reduced Castelli's Risk Index II
    • Reduced Atherogenic Coefficient
    • Reduced Lipoprotein Combine Index
    • Reduced Appetite Sensation Score

    • High evidence
    • Rigorous Journal
• February 11

  • Role of microbiota in pain: From bench to bedside.

    • 2025-02-11
    • Review
    • iMetaOmics 2(1)
    • • Huiguang Ren
      • Bo Cao
      • Qixuan Xu
      • Ruiyang Zhao
      • Hanghang Li
      • Bo Wei

    • PubMed: 41675715
    • DOI: 10.1002/imo2.58

    1 Insight on

    • Improved Gastrointestinal Symptoms

    • Low evidence
• February 12

  • Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis.

    • 2025-02-12
    • Meta-Analysis
    • Frontiers in cellular and infection microbiology 15
    • • Manning Li
      • Ying Xie

    • PubMed: 40012609
    • DOI: 10.3389/fcimb.2025.1441185

    9 Insights on

    • Reduced Abdominal Pain
    • Reduced Nausea
    • Reduced Constipation
    • Reduced Abdominal Distension
    • Improved H Pylori Eradication Rates
    • Reduced Diarrhea
    • Reduced Vomiting
    • Reduced Adverse Effects
    • Reduced Taste Disorder

    • High evidence

  • Black raspberry supplementation on overweight and Helicobacter pylori infected mild dementia patients a pilot study.

    • 2025-02-12
    • RCT
    • NPJ science of food 9(1)
    • • Yohanes Tandoro
      • Hui-Fang Chiu
      • Chei-Ling Tan
      • Ming-Hong Hsieh
      • Yi-Wen Huang
      • Jianhua Yu
      • Li-Shu Wang
      • Chi-Ho Chan
      • Chin-Kun Wang

    • PubMed: 39939643
    • DOI: 10.1038/s41538-024-00356-w

    3 Insights on

    • Reduced Body Mass Index
    • Improved Cognitive Function
    • Reduced Inflammatory Markers

    • High evidence
• February 13

  • Therapeutic Strategies to Modulate Gut Microbial Health: Approaches for Chronic Metabolic Disorder Management.

    • 2025-02-13
    • Review
    • Metabolites 15(2)
    • • Mariangela Rondanelli
      • Sara Borromeo
      • Alessandro Cavioni
      • Clara Gasparri
      • Ilaria Gattone
      • Elisa Genovese
      • Alessandro Lazzarotti
      • Leonardo Minonne
      • Alessia Moroni
      • Zaira Patelli
      • Claudia Razza
      • Claudia Sivieri
      • Eugenio Marzio Valentini
      • Gaetan Claude Barrile

    • PubMed: 39997751
    • DOI: 10.3390/metabo15020127

    1 Insight on

    • Improved Metabolic Health

    • Low evidence

  • Sheep-Derived Lactobacillus johnsonii M5 Enhances Immunity and Antioxidant Capacity, Alleviates Diarrhea, and Improves Intestinal Health in Early-Weaned Lambs.

    • 2025-02-13
    • Clinical Trial · n = 72
    • Microorganisms 13(2)
    • • Zhuo Wang
      • Yuwei Zhao
      • Dingkun Fan
      • Jixian Zhang
      • Qiyu Diao
      • Kai Cui

    • PubMed: 40005770
    • DOI: 10.3390/microorganisms13020404

    4 Insights on

    • Improved Immune Function
    • Improved Intestinal Health
    • Reduced Diarrhea
    • Increased Antioxidant Capacity

    • High evidence

  • Neurodevelopment and Growth 2 Years After Probiotic Supplementation in Extremely Preterm Infants: A Randomised Trial.

    • 2025-02-13
    • RCT · n = 134
    • Acta paediatrica (Oslo, Norway : 1992) 114(8)
    • • Erik Wejryd
      • Giovanna Marchini
      • Peter Bang
      • Baldvin Jonsson
      • Ulrika Ådén
      • Thomas Abrahamsson

    • PubMed: 39945202
    • DOI: 10.1111/apa.70030

    4 Insights on

    • Improved Growth
    • Improved Cognitive Score
    • Improved Language Score
    • Improved Motor Score

    • High evidence
    • Large Human Trial

  • The Association between Green Tea Consumption and Cognitive Function: A Meta-Analysis of Current Evidence.

    • 2025-02-13
    • Meta-Analysis · n = 929
    • Neuroepidemiology 60(1)
    • • Shiyao Zhou
      • Yating Zhu
      • Na Ren
      • Mishan Wu
      • Yu Liu

    • PubMed: 39947165
    • DOI: 10.1159/000543784

    2 Insights on

    • Reduced Dementia Risk
    • Reduced Risk of Cognitive Impairment

    • High evidence
• February 14

  • Effects of the Combined Supplementation of Caffeine and Rhodiola Rosea with Resistance Training on Lower Limb Explosive Power in Male Volleyball Players.

    • 2025-02-14
    • RCT
    • Nutrients 17(4)
    • • Zhaolong Wang
      • Haoyu Du
      • Huixin Li
      • Kai Zhao
      • Bingran Zhao
      • Yifei Ma
      • Jiashuo Zhang
      • Kangshuo Wu
      • Wei Jiang
      • Chang Liu

    • PubMed: 40005009
    • DOI: 10.3390/nu17040681

    4 Insights on

    • Improved Jump Height
    • Reduced Perceived Exertion
    • Increased Jump Height
    • Reduced Power Decline

    • High evidence
    • Rigorous Journal
• February 17

  • Promising Antidepressant Potential: The Role of Lactobacillus rhamnosus GG in Mental Health and Stress Response.

    • 2025-02-17
    • n = 56
    • Probiotics and antimicrobial proteins 17(6)
    • • Musab Işık
      • Fadime Köse
      • Cansu Özbayer
      • Özcan Budak
      • Rumeysa Keleş Kaya
      • Derya Güzel Erdoğan
      • Mehmet Arif Demirci
      • Songül Doğanay
      • Cahit Bağcı

    • PubMed: 39962033
    • DOI: 10.1007/s12602-025-10470-0

    5 Insights on

    • Improved Intestinal Barrier Function
    • Delayed Neurodegeneration
    • Improved Stress Response
    • Reduced Depression-like Behavior
    • Increased Brain-derived Neurotrophic Factor Level

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Effect of Nigella sativa seed extract on estradiol, FSH levels, and vaginal maturity index in menopausal women: A randomized controlled trial.

    • 2025-02-17
    • RCT
    • Narra J 5(1)
    • • Khairani Sukatendel
      • Reni H Hasibuan
      • Muhammad Fg Siregar
      • Dwi Faradina
      • Deri Edianto
      • Letta S Lintang
      • Muhammad Rusda
      • Vega Inriani

    • PubMed: 40352190
    • DOI: 10.52225/narra.v5i1.1399

    4 Insights on

    • Increased Vaginal Lactobacilli Levels
    • Increased Estradiol Level
    • No Change in FSH Level
    • Reduced Nausea Symptom Severity

    • High evidence

  • Development of Subtle Iron Deficiency During Vitamin E Treatment For Metabolic Dysfunction-Associated Steatotic Liver Disease.

    • 2025-02-17
    • Clinical Trial · n = 20
    • Journal of dietary supplements 22(2)
    • • Maren C Podszun
      • Ahmad Samer Alawad
      • Shilpa Lingala
      • Nevitt Morris
      • Wen Chun A Huang
      • Yaron Rotman

    • PubMed: 39960325
    • DOI: 10.1080/19390211.2025.2465414

    2 Insights on

    • Improved Iron Levels
    • Developed Anemia

    • Moderate evidence
• February 18

  • Engineered Probiotic-Based Biomaterials for Inflammatory Bowel Disease Treatment.

    • 2025-02-18
    • Review
    • Theranostics 15(8)
    • • Guangze Sang
      • Bingkai Wang
      • Yujie Xie
      • Yu Chen
      • Feng Yang

    • PubMed: 40093907
    • DOI: 10.7150/thno.103983

    5 Insights on

    • Reduced Intestinal Inflammation
    • Improved Gut Health
    • Improved Gastrointestinal Symptoms
    • Reduced Risk of Colorectal Cancer
    • Reduced Inflammatory Bowel Disease Symptoms

    • Low evidence

  • Targeting gut microbiota dysbiosis in inflammatory bowel disease: a systematic review of current evidence.

    • 2025-02-18
    • Systematic Review
    • Frontiers in medicine 12
    • • Asmaa Farah
      • Pradipta Paul
      • Anfal Sher Khan
      • Aparajita Sarkar
      • Sa'ad Laws
      • Ali Chaari

    • PubMed: 40041456
    • DOI: 10.3389/fmed.2025.1435030

    1 Insight on

    • Improved Effectiveness in Inflammatory Bowel Disease

    • High evidence

  • Comparison of Efficacy and Safety of Parenteral vs Oral Route of Vitamin B12 Supplementation for the Treatment of Vitamin B12 Deficiency Anemia in Children: A Systematic Review.

    • 2025-02-18
    • Systematic Review
    • Nutrition reviews 83(9)
    • • Meenakshi Sachdeva
      • Abhishek Purohit
      • Meenakshi Malik
      • Lovely Jain
      • Pranita Pradhan
      • Joseph L Mathew

    • PubMed: 39964959
    • DOI: 10.1093/nutrit/nuae227

    2 Insights on

    • Increased Hemoglobin Levels
    • Increased Vitamin B12 Levels

    • High evidence

  • Biotinidase Deficiency Induced Optic Neuropathy: A Case Report and Literature Review.

    • 2025-02-18
    • Review
    • Neuro-ophthalmology (Aeolus Press) 49(3)
    • • Angela A Cao
      • Meghan M Brown
      • Michael S Lee
      • Anita M Rashidi
      • Vania Rashidi

    • PubMed: 40190376
    • DOI: 10.1080/01658107.2024.2424209

    1 Insight on

    • Improved Visual Function

    • Low evidence
• February 19

  • Characterization and Anti-Inflammatory Effects of Akkermansia muciniphila-Derived Extracellular Vesicles.

    • 2025-02-19
    • Microorganisms 13(2)
    • • Sasa Zhao
      • Jie Xiang
      • Minhazul Abedin
      • Jingyi Wang
      • Zhiwen Zhang
      • Zhongwei Zhang
      • Hua Wu
      • Junsong Xiao

    • PubMed: 40005829
    • DOI: 10.3390/microorganisms13020464

    2 Insights on

    • Reduced Intestinal Inflammation
    • Reduced Oxidative Stress

    • Low evidence

  • Genomic insights into the beneficial potential of Bifidobacterium and Enterococcus strains isolated from Cameroonian infants.

    • 2025-02-19
    • Observational · n = 26
    • Microbial genomics 11(2)
    • • Pierre Marie Kaktcham
      • Magdalena Kujawska
      • Edith Marius Foko Kouam
      • Laverdure Tchamani Piame
      • Michele Letitia Tchabou Tientcheu
      • Julia Mueller
      • Angela Felsl
      • Bastian-Alexander Truppel
      • François Zambou Ngoufack
      • Lindsay J Hall

    • PubMed: 39969280
    • DOI: 10.1099/mgen.0.001354

    1 Insight on

    • Detected Antimicrobial Resistance Genes

    • Low evidence
• February 20

  • Microencapsulation and Probiotic Characterization of Lactiplantibacillus plantarum LM-20: Therapeutic Application in a Murine Model of Ulcerative Colitis.

    • 2025-02-20
    • Nutrients 17(5)
    • • Cynthia Garfias Noguez
      • Morayma Ramírez Damián
      • Alicia Ortiz Moreno
      • Yazmín Karina Márquez Flores
      • Liliana Alamilla Beltrán
      • Mario Márquez Lemus
      • Luis G Bermúdez Humarán
      • María Elena Sánchez Pardo

    • PubMed: 40077619
    • DOI: 10.3390/nu17050749

    1 Insight on

    • Reduced Ulcerative Colitis Symptoms

    • Low evidence
    • Rigorous Journal
    • Animal Study
• February 21

  • Effectiveness of Herbal Medicines with Anti-Inflammatory, Antimicrobial, and Antioxidant Properties in Improving Oral Health and Treating Gingivitis and Periodontitis: A Systematic Review.

    • 2025-02-21
    • Systematic Review
    • Nutrients 17(5)
    • • Giuseppina Malcangi
      • Angelo Michele Inchingolo
      • Lucia Casamassima
      • Irma Trilli
      • Laura Ferrante
      • Francesco Inchingolo
      • Andrea Palermo
      • Alessio Danilo Inchingolo
      • Gianna Dipalma

    • PubMed: 40077632
    • DOI: 10.3390/nu17050762

    3 Insights on

    • Reduced Microbial Load
    • Reduced Inflammation
    • Improved Gingival Health

    • High evidence
    • Rigorous Journal

  • Therapeutic Potential of Gynostemma pentaphyllum Extract for Hair Health Enhancement: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

    • 2025-02-21
    • RCT
    • Nutrients 17(5)
    • • Jihyun Lee
      • Yongxun Jin
      • Xinrui Zhang
      • Myoungrae Kim
      • Ayoung Koh
      • Shuyi Zhou
      • Changhyun Lee
      • Minji Seo
      • Shinjae Kim
      • Suye Jo
      • Youngjoo Kim
      • Seri Kwon
      • Kyuhan Kim
      • Chanyeong Heo

    • PubMed: 40077637
    • DOI: 10.3390/nu17050767

    5 Insights on

    • Increased Hair Density
    • Increased Hair Elasticity
    • Increased Hair Diameter
    • Improved Hair Glossiness
    • Improved Subjective Satisfaction

    • High evidence
    • Rigorous Journal
• February 22

  • Does supplementation with pine bark extract improve cardiometabolic risk factors? A systematic review and meta-analysis.

    • 2025-02-22
    • Meta-Analysis · n = 685
    • BMC complementary medicine and therapies 25(1)
    • • Shooka Mohammadi
      • Tamas Fulop
      • Abdelouahed Khalil
      • Sara Ebrahimi
      • Motahareh Hasani
      • Somayeh Ziaei
      • Farnaz Farsi
      • Elham Mirtaheri
      • Mostafa Afsharianfar
      • Javad Heshmati

    • PubMed: 39987124
    • DOI: 10.1186/s12906-025-04819-9

    3 Insights on

    • Reduced Body Weight
    • Reduced LDL Cholesterol
    • Reduced Fasting Blood Glucose Levels

    • High evidence
• February 24

  • Inter-individual differences in the blood pressure lowering effects of dietary nitrate: a randomised double-blind placebo-controlled replicate crossover trial.

    • 2025-02-24
    • RCT
    • European journal of nutrition 64(2)
    • • Eleanor Hayes
      • Shatha Alhulaefi
      • Mario Siervo
      • Eleanor Whyte
      • Rachel Kimble
      • Jamie Matu
      • Alex Griffiths
      • Marc Sim
      • Mia Burleigh
      • Chris Easton
      • Lorenzo Lolli
      • Greg Atkinson
      • John C Mathers
      • Oliver M Shannon

    • PubMed: 39992469
    • DOI: 10.1007/s00394-025-03616-x

    2 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure

    • High evidence
    • Rigorous Journal

  • Hericium erinaceus: A possible future therapeutic treatment for the prevention and delayed progression of Alzheimer's disease? - A narrative review.

    • 2025-02-24
    • Review
    • Nutrition research reviews 38(2)
    • • Nisha Cornford
      • Margaret Charnley

    • PubMed: 39988819
    • DOI: 10.1017/s0954422425000058

    1 Insight on

    • Improved Cognitive Function

    • Low evidence
• February 25

  • Can We Modulate Our Second Brain and Its Metabolites to Change Our Mood? A Systematic Review on Efficacy, Mechanisms, and Future Directions of "Psychobiotics".

    • 2025-02-25
    • Systematic Review
    • International journal of molecular sciences 26(5)
    • • Stefania Garzone
      • Ioannis Alexandros Charitos
      • Manuela Mandorino
      • Maria Elena Maggiore
      • Loredana Capozzi
      • Bujar Cakani
      • Gabriel César Dias Lopes
      • Luisella Bocchio-Chiavetto
      • Marica Colella

    • PubMed: 40076598
    • DOI: 10.3390/ijms26051972

    3 Insights on

    • Reduced Anxiety
    • Improved Mood
    • Reduced Stress

    • High evidence
    • Rigorous Journal

  • Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: A randomized controlled trial.

    • 2025-02-25
    • RCT
    • Nutrition, metabolism, and cardiovascular diseases : NMCD 35(8)
    • • Bangwei Chen
      • Yaxin Li
      • Zhiming Li
      • Xiaojie Hu
      • Hefu Zhen
      • Hongyun Chen
      • Chao Nie
      • Yong Hou
      • Shida Zhu
      • Liang Xiao
      • Tao Li

    • PubMed: 40087044
    • DOI: 10.1016/j.numecd.2025.103964

    1 Insight on

    • Reduced Low-Density Lipoprotein Level

    • High evidence

  • In vitro modulation of proinflammatory and proteolytic activities of Porphyromonas gingivalis by selected lactobacilli.

    • 2025-02-25
    • Journal of oral microbiology 17(1)
    • • Johana R Naja
      • Leyla Desparois
      • Elvira M Hebert
      • Maria Elena Fátima Nader
      • Lucila Saavedra
      • Carlos J Minahk
      • Vanessa P Houde

    • PubMed: 40013015
    • DOI: 10.1080/20002297.2025.2469894

    1 Insight on

    • Reduced Inflammatory Response

    • Low evidence
• February 26

  • Acute effects of Hibiscus sabdariffa on blood pressure and cognitive function.

    • 2025-02-26
    • RCT
    • Nutritional neuroscience 28(9)
    • • Lucy Ellis
      • Stephania Aragón-Rojas
      • Louise Dye
      • Christine Boesch

    • PubMed: 40009760
    • DOI: 10.1080/1028415x.2025.2462944

    6 Insights on

    • Improved Cognitive Function
    • Reduced Blood Pressure
    • Reduced Postprandial Glucose
    • Improved Delayed Word Recall
    • Reduced Retroactive Interference
    • Improved Pattern Separation

    • High evidence
• February 27

  • The Significance of Probiotics in Aquaculture: A Review of Research Trend and Latest Scientific Findings.

    • 2025-02-27
    • Review
    • Antibiotics (Basel, Switzerland) 14(3)
    • • Elshafia Ali Hamid Mohammed
      • Abdelhakam Esmaeil Mohamed Ahmed
      • Béla Kovács
      • Károly Pál

    • PubMed: 40149052
    • DOI: 10.3390/antibiotics14030242

    1 Insight on

    • No Human Health Outcome Reported

    • Low evidence

  • Targeting gut microbiota as a therapeutic approach for neurodegenerative diseases.

    • 2025-02-27
    • Review
    • Neuroprotection (Chichester, England) 3(2)
    • • Tobiloba S Olajide
      • Omamuyovwi M Ijomone

    • PubMed: 40589476
    • DOI: 10.1002/nep3.70000

    3 Insights on

    • Improved Cognitive Function
    • Improved Neuroprotection
    • Improved Motor Function

    • Low evidence

  • Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.

    • 2025-02-27
    • RCT · n = 165
    • Nutrients 17(5)
    • • Femke de Vries
      • Rudolf Bittner
      • Katarzyna Maresz
      • François Machuron
      • Olav Gåserød
      • Jean-François Jeanne
      • Leon J Schurgers

    • PubMed: 40077685
    • DOI: 10.3390/nu17050815

    3 Insights on

    • Reduced Blood Pressure
    • Reduced Vascular Stiffness
    • Increased Distensibility Coefficient

    • High evidence
    • Large Human Trial
    • Rigorous Journal

  • Clinical significance of perioperative probiotic intervention on recovery following intestinal surgery.

    • 2025-02-27
    • RCT · n = 60
    • World journal of gastrointestinal surgery 17(2)
    • • Yang Wu
      • Xin Zhang
      • Guan-Qiao Wang
      • Yan Jiao

    • PubMed: 40062001
    • DOI: 10.4240/wjgs.v17.i2.97503

    1 Insight on

    • Improved Gastrointestinal Recovery

    • High evidence

  • Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis.

    • 2025-02-27
    • Meta-Analysis · n = 1,049
    • Neuropsychopharmacology reports 45(1)
    • • Minoru Urata
      • Hitoshi Sakurai
      • Fumihiko Ueno
      • Taku Maruki
      • Teruo Tada
      • Takahito Uchida
      • Yasuyuki Matsumoto
      • Masami Murao
      • Masayuki Tomita
      • Hajime Baba
      • Masaki Kato
      • Takashi Tsuboi
      • Koichiro Watanabe

    • PubMed: 40014460
    • DOI: 10.1002/npr2.70008

    1 Insight on

    • Improved Depressive Symptoms

    • High evidence
• February 28

  • Streptococcus salivarius and Ligilactobacillus salivarius: Paragons of Probiotic Potential and Reservoirs of Novel Antimicrobials.

    • 2025-02-28
    • Review
    • Microorganisms 13(3)
    • • McKinley D Williams
      • Leif Smith

    • PubMed: 40142448
    • DOI: 10.3390/microorganisms13030555

    6 Insights on

    • Reduced Gastrointestinal Symptoms
    • Improved Immune Response
    • Improved Gut Microbiota Balance
    • Reduced Gastrointestinal Infections
    • Improved Gut Microbiome Composition
    • Reduced Pathogen Colonization

    • Low evidence

  • Daily Vitamin D3 Versus Stoss Vitamin D3 for Correction of 25OHD Deficiency in Children with Inflammatory Bowel Disease, a Randomised Controlled Trial.

    • 2025-02-28
    • RCT · n = 74
    • Digestive diseases and sciences 70(5)
    • • Jonathan E M O'Donnell
      • Steven T Leach
      • Nerissa L Bowcock
      • Siying Chen
      • Nitin Gupta
      • Kevin Jiang
      • Robert N Lopez
      • Rachel Messenger
      • Lily Nahidi
      • Amanda Shapiro
      • Andrew S Day
      • Daniel A Lemberg

    • PubMed: 40021606
    • DOI: 10.1007/s10620-025-08913-3

    12 Insights on

    • Reduced Faecal Calprotectin
    • Increased Hemoglobin Levels
    • Increased Platelet Count
    • Reduced Vitamin D Deficiency
    • Changed Serum Calcium Level
    • Changed Magnesium Level
    • Changed Phosphate Level
    • Changed Parathyroid Hormone Level
    • Changed Albumin Level
    • Reduced S100A12 Level
    • Improved Clinical Disease Activity
    • Changed Anthropometric Measure

    • High evidence
    • Rigorous Journal

  • Rehydration Beverages Made from Quercus sideroxyla Infusion, Probiotics, and Prebiotics: Antioxidant and Anti-Inflammatory Potential.

    • 2025-02-28
    • Foods (Basel, Switzerland) 14(5)
    • • Carlos Alonso Salas-Ramírez
      • Martha Rocío Moreno-Jiménez
      • Nuria Elizabeth Rocha-Guzmán
      • José Alberto Gallegos-Infante
      • Rubén Francisco González-Laredo
      • Silvia Marina González Herrera
      • Manuel Efraín González-Mercado
      • Karen Marlenne Herrera-Rocha
      • Manuel Humberto Cháirez-Ramirez

    • PubMed: 40077540
    • DOI: 10.3390/foods14050837

    1 Insight on

    • Reduced Inflammation

    • Low evidence

  • Clinical Evaluation of Ganoderma lucidum Spore Oil for Triglyceride Reduction: A Randomized, Double-Blind, Crossover Study.

    • 2025-02-28
    • RCT · n = 110
    • Nutrients 17(5)
    • • Xinyi Wang
      • Xufeng Wang
      • Liang Zhao
      • Feng Zhou

    • PubMed: 40077714
    • DOI: 10.3390/nu17050844

    6 Insights on

    • Reduced Low-Density Lipoprotein Level
    • Reduced Triglyceride Levels
    • Improved Liver Function
    • Increased HDL Cholesterol Levels
    • Reduced Blood Cholesterol
    • Improved Renal Function

    • High evidence
    • Large Human Trial
    • Rigorous Journal
• Undated – 10 supplement studies

  • Probiotic biofilm modified scaffolds for facilitating osteomyelitis treatment through sustained release of bacteriophage and regulated macrophage polarization.

    • 2025-02
    • Materials today. Bio 30
    • • Junwei Su
      • Yifan Wu
      • Zheng Wang
      • Dong Zhang
      • Xianquan Yang
      • Yong Zhao
      • Aixi Yu

    • PubMed: 39866782
    • DOI: 10.1016/j.mtbio.2025.101444

    1 Insight on

    • Reduced Bacterial Infection Rates

    • Low evidence

  • Managing strategies of chemotherapy and radiotherapy-induced oral mucositis.

    • 2025-02
    • Review
    • Cancer treatment reviews 133
    • • Yuqi Wu
      • Wenjin Shi
      • Chunyu Li
      • Xiangfei Liu
      • Yuchen Jiang
      • Yan Qiu
      • Qianming Chen
      • Xiaobo Luo

    • PubMed: 39799794
    • DOI: 10.1016/j.ctrv.2025.102883

    1 Insight on

    • Reduced Oral Mucositis Severity

    • Low evidence

  • Plant and Animal Protein Intake and Transitions From Multimorbidity to Frailty and Mortality in Older Adults.

    • 2025-02
    • Observational · n = 1,868
    • Journal of cachexia, sarcopenia and muscle 16(1)
    • • Aitana Vázquez-Fernández
      • Francisco F Caballero
      • Humberto Yévenes-Briones
      • Ellen A Struijk
      • Ana Baylin
      • Teresa T Fung
      • Esther Lopez-Garcia

    • PubMed: 39971333
    • DOI: 10.1002/jcsm.13729

    3 Insights on

    • Reduced Mortality Rate
    • Reduced Frailty Risk
    • Reduced Mortality from Frailty

    • High evidence

  • Preterm-birth-prevention with Lactobacillus crispatus oral probiotics: Protocol for a double blinded randomised placebo-controlled trial (the PrePOP study).

    • 2025-02
    • RCT · n = 126
    • Contemporary clinical trials 149
    • • Gillian A Corbett
      • Siobhan Corcoran
      • Conor Feehily
      • Benedetta Soldati
      • Anthony Rafferty
      • David A MacIntyre
      • Paul D Cotter
      • Fionnuala M McAuliffe

    • PubMed: 39701375
    • DOI: 10.1016/j.cct.2024.107776

    2 Insights on

    • Reduced Preterm Births
    • Increased Abundance of Lactobacillus Crispatus

    • High evidence
    • Large Human Trial

  • Multimodal insights into adult neurogenesis: An integrative review of multi-omics approaches.

    • 2025-02
    • Review
    • Heliyon 11(4)
    • • Jin Li
      • Leyi Huang
      • Wenjie Xiao
      • Jingyi Kong
      • Minghua Hu
      • Aihua Pan
      • Xiaoxin Yan
      • Fulian Huang
      • Lily Wan

    • PubMed: 40051854
    • DOI: 10.1016/j.heliyon.2025.e42668

    1 Insight on

    • Improved Sleep Quality

    • Low evidence

  • The Pharmacokinetic Interaction Between Metformin and the Natural Product Goldenseal Is Metformin Dose-Dependent: A Three-Arm Crossover Study in Adults With Type 2 Diabetes.

    • 2025-02
    • RCT
    • Clinical and translational science 18(2)
    • • James T Nguyen
      • Christopher M Arian
      • Rakshit S Tanna
      • Maxey G Cherel
      • Matthew E Layton
      • John R White
      • Kenneth E Thummel
      • Mary F Paine

    • PubMed: 39943692
    • DOI: 10.1111/cts.70120

    1 Insight on

    • Reduced Hemoglobin A1c

    • High evidence

  • Isolation and optimization of Bacillus thuringiensis BRB-3 isolated from germinated black upland rice seeds for GABA production.

    • 2025-02
    • n = 38
    • Heliyon 11(3)
    • • Rungnapha Wannasutta
      • Sophon Boonlue
      • Nuntavun Riddech
      • Wiyada Mongkolthanaruk

    • PubMed: 39916844
    • DOI: 10.1016/j.heliyon.2025.e41884

    1 Insight on

    • Increased GABA Production

    • Low evidence

  • Assessment of the feed additive consisting of Lactiplantibacillus plantarumCECT 4528 for all animal species for the renewal of its authorisation (Centro Sperimentale del Latte S.r.l.).

    • 2025-02
    • Review
    • EFSA journal. European Food Safety Authority 23(2)
    • • Roberto Edoardo Villa
      • Giovanna Azimonti
      • Eleftherios Bonos
      • Henrik Christensen
      • Mojca Durjava
      • Birgit Dusemund
      • Ronette Gehring
      • Boet Glandorf
      • Maryline Kouba
      • Marta López-Alonso
      • Francesca Marcon
      • Carlo Nebbia
      • Alena Pechová
      • Miguel Prieto-Maradona
      • Ilen Röhe
      • Katerina Theodoridou
      • Montserrat Anguita
      • Nicole Bozzi Cionci
      • Rosella Brozzi
      • Matteo L Innocenti
      • Piera Valeri
      • Yolanda García-Cazorla

    • PubMed: 39973913
    • DOI: 10.2903/j.efsa.2025.9247

    1 Insight on

    • No Adverse Health Effects

    • Low evidence

  • An open-label, randomized, controlled trial on the benefit of β-hydroxy-β-methyl butyrate, l-arginine, l-glutamine combination beverages and locomotion training as supportive care for the treatment of unresectable hepatocellular carcinoma using lenvatinib: A pilot study (HELLO study).

    • 2025-02
    • RCT · n = 20
    • Clinical nutrition ESPEN 65
    • • Atsushi Naganuma
      • Fujio Makita
      • Rie Sugimoto
      • Masahiro Kikuchi
      • Kiyoshi Furuta
      • Satoru Iwamoto
      • Ryotaro Sakamori
      • Hirotaka Kouno
      • Keisuke Ario
      • Hiroshi Yatsuhashi

    • PubMed: 39675424
    • DOI: 10.1016/j.clnesp.2024.12.005

    1 Insight on

    • Preserved Skeletal Muscle Index

    • High evidence

  • Effect of feeding biochar, oat hulls, yeast fermentate, and organic acids on reduction of Campylobacter in free-range broilers from hatching to slaughter.

    • 2025-02
    • RCT · n = 140
    • Poultry science 104(2)
    • • Nao Takeuchi-Storm
      • Cristina Calvo-Fernandez
      • Annette Nygaard Jensen
      • Giulia Ravenni
      • Marianne Sandberg
      • Ulrik Birk Henriksen
      • Brian Lassen

    • PubMed: 39731870
    • DOI: 10.1016/j.psj.2024.104706

    1 Insight on

    • Reduced Bacterial Colonization

    • Low evidence
    • Animal Study