June 2022 Supplement Research Papers

• June 1

  • Red Raspberry and Fructo-Oligosaccharide Supplementation, Metabolic Biomarkers, and the Gut Microbiota in Adults with Prediabetes: A Randomized Crossover Clinical Trial.

    • 2022-06-01
    • RCT · n = 26
    • The Journal of nutrition 152(6)
    • • Xuhuiqun Zhang
      • Anqi Zhao
      • Amandeep K Sandhu
      • Indika Edirisinghe
      • Britt M Burton-Freeman

    • PubMed: 35421233
    • DOI: 10.1093/jn/nxac037

    5 Insights on

    • Improved Insulin Sensitivity
    • Reduced LDL Cholesterol
    • Reduced Total Cholesterol
    • Reduced Hepatic Insulin Resistance
    • Improved Insulin Secretion Rate

    • High evidence

  • Effects of yeast hydrolysate supplementation on intestinal morphology, barrier, and anti-inflammatory functions of broilers.

    • 2022-06-01
    • RCT · n = 320
    • Animal bioscience 35(6)
    • • Ting Wang
      • Kang Cheng
      • QiMing Li
      • Tian Wang

    • PubMed: 34991218
    • DOI: 10.5713/ab.21.0374

    4 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Intestinal Permeability
    • Improved Intestinal Morphology
    • Reduced Intestinal Inflammation

    • High evidence

  • Bacillus amyloliquefaciens and Saccharomyces cerevisiae feed supplements improve growth performance and gut mucosal architecture with modulations on cecal microbiota in red-feathered native chickens

    • 2022-06-01
    • RCT · n = 18,000
    • Animal Bioscience 35(6)
    • • Tzu-Tai Lee
      • C. Chou
      • Chinling Wang
      • Hsuan-Ying Lu
      • Wen-Yuan Yang

    • PubMed: 34991225
    • DOI: 10.5713/ab.21.0318

    3 Insights on

    • Improved Growth Performance
    • Improved Metabolic Function
    • Improved Intestinal Mucosa Architecture

    • Low evidence
    • Animal Study

  • Association between Nutrition Protocol with Clostridium butyricum MIYAIRI 588 and Reduced Incidence of Clostridioides difficile Infection in Critically Ill Patients: A Single-Center, Before-and-After Study.

    • 2022-06-01
    • RCT · n = 1,802
    • Surgical Infections 23(5)
    • • Takeaki Sato
      • D. Kudo
      • S. Kushimoto

    • PubMed: 35647891
    • DOI: 10.1089/sur.2022.030

    6 Insights on

    • Reduced Incidence of Clostridium Difficile Infection
    • Reduced Recurrent Clostridioides difficile Infection Incidence
    • Reduced ICU Length of Stay
    • Reduced Clostridioides difficile Infection
    • Reduced Recurrent Clostridioides Difficile Infection
    • Reduced Length of Intensive Care Unit Stay

    • High evidence
    • Large Human Trial
• June 2

  • Traditional Fermented Foods and Beverages from around the World and Their Health Benefits.

    • 2022-06-02
    • Review
    • Microorganisms 10(6)
    • • Leonel Cuamatzin-García
      • Paola Rodríguez-Rugarcía
      • Elie Girgis El-Kassis
      • Georgina Galicia
      • María de Lourdes Meza-Jiménez
      • Ma Del Rocío Baños-Lara
      • Diego Salatiel Zaragoza-Maldonado
      • Beatriz Pérez-Armendáriz

    • PubMed: 35744669
    • DOI: 10.3390/microorganisms10061151

    1 Insight on

    • Improved Gastrointestinal Health

    • Low evidence
• June 6

  • Postbiotics effects of Lactobacillus fermentate on intestinal health, mucosa-associated microbiota, and growth efficiency of nursery pigs challenged with F18 +  Escherichia coli.

    • 2022-06-06
    • RCT
    • Journal of Animal Science 100(8)
    • • Xiangyi Xu
      • M. E. Duarte
      • S. Kim

    • PubMed: 35666999
    • DOI: 10.1093/jas/skac210

    9 Insights on

    • Reduced Diarrhea Rate
    • Improved Average Daily Gain
    • Improved Growth Performance
    • Increased Beneficial Gut Microbiota
    • Reduced Fecal Score
    • Reduced Crypt Cell Proliferation
    • Increased Alpha Diversity of Jejunal Mucosa-Associated Microbiota
    • Increased Propionibacterium Acnes Levels
    • Reduced Protein Carbonyl Levels

    • High evidence
    • Rigorous Journal
• June 8

  • Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis.

    • 2022-06-08
    • Systematic Review · n = 191
    • Frontiers in pharmacology 13
    • • Kaushik Chattopadhyay
      • Haiquan Wang
      • Jaspreet Kaur
      • Gamze Nalbant
      • Abdullah Almaqhawi
      • Burak Kundakci
      • Jeemon Panniyammakal
      • Michael Heinrich
      • Sarah Anne Lewis
      • Sheila Margaret Greenfield
      • Nikhil Tandon
      • Tuhin Kanti Biswas
      • Sanjay Kinra
      • Jo Leonardi-Bee

    • PubMed: 35754481
    • DOI: 10.3389/fphar.2022.821810

    1 Insight on

    • Reduced Glycated Hemoglobin

    • High evidence

  • Bifidobacterium animalis subsp. lactis XLTG11 improves antibiotic-related diarrhea by alleviating inflammation, enhancing intestinal barrier function and regulating intestinal flora.

    • 2022-06-08
    • Clinical Trial
    • Food & Function 13(11)
    • • Baofeng Xu
      • Shengnan Liang
      • Jiayi Zhao
      • Xuetong Li
      • Jiayao Guo
      • Bowen Xin
      • Bailiang Li
      • G. Huo
      • Weiwei Ma

    • PubMed: 35616024
    • DOI: 10.1039/d1fo04305f

    29 Insights on

    • Improved Gut Microbiota Diversity
    • Improved Intestinal Barrier Function
    • Increased Short-Chain Fatty Acid Levels
    • Improved Intestinal Flora Diversity
    • Reduced Antibiotic-Associated Diarrhea
    • Reduced Intestinal Permeability
    • Increased Anti-Inflammatory Cytokine Levels
    • Reduced Pro-Inflammatory Cytokines
    • Improved AAD-Related Symptoms
    • Reduced Inflammatory Response
    • Relieved Intestinal Impairments
    • Reduced Intestinal Inflammation
    • Reduced Inflammation Levels
    • Increased Short-Chain Fatty Acid Production
    • Reduced Pro-inflammatory Cytokine Levels
    • Increased Barrier-Preserving Protein Levels
    • Enhanced Anti-inflammatory Response
    • Improved Gut Microbiome Composition
    • Improved Intestinal Flora
    • Reduced Inflammation
    • Improved Short-Chain Fatty Acid Production
    • Reduced Inflammatory Pathways
    • Enhanced SCFA Production
    • Reduced Antibiotic-Associated Diarrhea Symptoms
    • Reduced Intestinal Pathology
    • Improved Recovery of Intestinal Flora
    • Improved Antibiotic-Associated Diarrhea
    • Improved Gut Flora Diversity
    • Improved Recovery from Antibiotic-Associated Diarrhea

    • Low evidence
    • Animal Study

  • A Platform for Co-Culture of Primary Human Colonic Epithelium With Anaerobic Probiotic Bacteria

    • 2022-06-08
    • Frontiers in Bioengineering and Biotechnology 10
    • • Raehyun Kim
      • Yuli Wang
      • C. Sims
      • N. Allbritton

    • PubMed: 35757791
    • DOI: 10.3389/fbioe.2022.890396

    1 Insight on

    • Reduced Inflammation Levels

    • Low evidence

  • Dietary supplementation with Pediococcus pentosaceus enhances the innate immune response in and promotes growth of Litopenaeus vannamei shrimp.

    • 2022-06-08
    • RCT
    • Journal of Fish Diseases 45(9)
    • • Bao Le
      • Dong-geun Kim
      • N. N. Phước
      • Nguyen Thi Hoang Linh
      • S. Yang

    • PubMed: 35675520
    • DOI: 10.1111/jfd.13666

    8 Insights on

    • Increased Body Weight
    • Improved Immune Response
    • Improved Cell Survival Rates
    • Enhanced Innate Immune Function
    • Improved Weight Gain
    • Improved Enzyme Activity
    • Increased Protease Levels
    • Improved Survival Rate Following WSSV Challenge

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Probiotics for Reduction of Examination Stress in Students (PRESS) study: A randomized, double-blind, placebo-controlled trial of the probiotic Lacticaseibacillus rhamnosus HN001

    • 2022-06-08
    • RCT · n = 483
    • PLOS ONE 17(6)
    • • R. Slykerman
      • Eileen Li
      • E. Mitchell

    • PubMed: 35675229
    • DOI: 10.1371/journal.pone.0267778

    1 Insight on

    • Reduced Examination Stress

    • High evidence
    • Large Human Trial
    • Rigorous Journal
• June 9

  • Regulatory Effect of Lactiplantibacillus plantarum 2-33 on Intestinal Microbiota of Mice With Antibiotic-Associated Diarrhea

    • 2022-06-09
    • Frontiers in Nutrition 9
    • • Wuyundalai Bao
      • Yuxi He
      • Jing Yu
      • Mingchao Liu
      • Xiaofeng F. Yang
      • Na Ta
      • Enxin Zhang
      • Chengyuan Liang

    • PubMed: 35757257
    • DOI: 10.3389/fnut.2022.921875

    6 Insights on

    • Improved Intestinal Flora Diversity
    • Increased Anti-Inflammatory Cytokine Levels
    • Reduced Pro-Inflammatory Cytokines
    • Reduced Diarrhea Symptoms
    • Improved Metabolic Function
    • Reduced Pro-inflammatory Cytokine Levels

    • Low evidence
• June 13

  • Intrahepatic Cholestasis of Pregnancy Increases Inflammatory Susceptibility in Neonatal Offspring by Modulating Gut Microbiota.

    • 2022-06-13
    • Observational
    • Frontiers in immunology 13
    • • Qiong-Xi Lin
      • Wan-Wen Huang
      • Wei Shen
      • Xiao-Shi Deng
      • Zi-Yu Tang
      • Zhen-Hui Chen
      • Wei Zhao
      • Hong-Ying Fan

    • PubMed: 35769469
    • DOI: 10.3389/fimmu.2022.889646

    3 Insights on

    • Reduced Inflammatory Response
    • Improved Intestinal Immunity
    • Reduced Susceptibility to Inflammatory Exposure

    • Low evidence
    • Animal Study
• June 14

  • Role of Phytoestrogen-Rich Bioactive Substances (Linum usitatissimum L., Glycine max L., Trifolium pratense L.) in Cardiovascular Disease Prevention in Postmenopausal Women: A Systematic Review and Meta-Analysis.

    • 2022-06-14
    • Meta-Analysis
    • Nutrients 14(12)
    • • Agata Błaszczuk
      • Agnieszka Barańska
      • Wiesław Kanadys
      • Maria Malm
      • Monika Elżbieta Jach
      • Urszula Religioni
      • Rafał Wróbel
      • Jolanta Herda
      • Małgorzata Polz-Dacewicz

    • PubMed: 35745197
    • DOI: 10.3390/nu14122467

    4 Insights on

    • Reduced Low-Density Lipoprotein Level
    • Increased HDL Cholesterol Levels
    • Reduced Total Cholesterol
    • Reduced High-Density Lipoprotein Cholesterol Level

    • High evidence
    • Rigorous Journal
• June 15

  • Bifidobacterium adolescentis Is Effective in Relieving Type 2 Diabetes and May Be Related to Its Dominant Core Genome and Gut Microbiota Modulation Capacity

    • 2022-06-15
    • Clinical Trial
    • Nutrients 14(12)
    • • Xin Qian
      • Qian Si
      • Guopeng Lin
      • Minmin Zhu
      • Jing-Yi Lu
      • H. Zhang
      • G. Wang
      • Wei Chen

    • PubMed: 35745208
    • DOI: 10.3390/nu14122479

    5 Insights on

    • Improved Insulin Sensitivity
    • Reduced Inflammation Levels
    • Restored Gut Microbiota Homeostasis
    • Increased Short-Chain Fatty Acid-Producing Gut Flora
    • Reduced Type 2 Diabetes Symptoms

    • Low evidence
    • Animal Study

  • Effects of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 on Overweight and the Gut Microbiota in Humans: Randomized, Double-Blinded, Placebo-Controlled Clinical Trial

    • 2022-06-15
    • RCT · n = 72
    • Nutrients 14(12)
    • • S. Mo
      • Ki-Tae Lee
      • H. Hong
      • D. Hong
      • Seung-Hee Jung
      • Soo-Dong Park
      • Jae-Jung Shim
      • Jung-Lyoul Lee

    • PubMed: 35745214
    • DOI: 10.3390/nu14122484

    3 Insights on

    • Reduced Waist Circumference
    • Reduced Body Weight
    • Increased Adiponectin Levels

    • High evidence
• June 16

  • Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.

    • 2022-06-16
    • Meta-Analysis · n = 6,853
    • Journal of bone and mineral metabolism 40(5)
    • • Ming Zhou
      • Shiliang Han
      • Wenpeng Zhang
      • Dan Wu

    • PubMed: 35711002
    • DOI: 10.1007/s00774-022-01342-6

    2 Insights on

    • Increased Total Hip Bone Mineral Density
    • Increased Adverse Reactions

    • High evidence

  • Effect of Dietary Supplementation of Bacillus subtilis on Growth Performance, Organ Weight, Digestive Enzyme Activities, and Serum Biochemical Indices in Broiler

    • 2022-06-16
    • RCT
    • Animals 12(12)
    • • Taha M. Mohamed
      • Weizhong Sun
      • G. Z. Bumbie
      • W. Dosoky
      • Z. Rao
      • P. Hu
      • Liuting Wu
      • Zhiru Tang

    • PubMed: 35739895
    • DOI: 10.3390/ani12121558

    18 Insights on

    • Reduced Low-Density Lipoprotein Level
    • Increased Body Weight
    • Increased Serum Albumin Levels
    • Improved Growth Performance
    • Enhanced Digestive Enzyme Activity
    • Reduced Serum Total Cholesterol Levels
    • Increased Serum Total Protein Levels
    • Reduced Triglycerides
    • Increased Bursa of Fabricius Weight
    • Increased Body Weight Gain
    • Improved Serum Biochemical HA Levels
    • Reduced Very Low-Density Lipoprotein
    • Increased Serum Protein Levels
    • Increased High-Density Lipoprotein Levels
    • Increased Serum Lipase Levels
    • Increased Serum Pepsinogen Activity
    • Increased Serum Amylase Activity
    • Reduced Harmful Lipid Levels

    • High evidence
    • Rigorous Journal
• June 17

  • Current Progress and Future Perspectives on the Use of Bacillus clausii

    • 2022-06-17
    • Review
    • Microorganisms 10(6)
    • • E. Ghelardi
      • A. T. Abreu y Abreu
      • Christian Boggio Marzet
      • G. Álvarez Calatayud
      • M. I. Perez
      • Ana Paula Moschione Castro

    • PubMed: 35744764
    • DOI: 10.3390/microorganisms10061246

    8 Insights on

    • Improved Intestinal Barrier Function
    • Increased Antioxidant Activity
    • Improved Gastrointestinal Tolerance
    • Reduced Inflammation
    • Modulated Gut Microbiota
    • Enhanced Immunomodulatory Function
    • Improved Physiological Parameters
    • Additional Therapeutic Benefits

    • Moderate evidence
    • Rigorous Journal

  • Lacticaseibacillus rhamnosus HA-114 improves eating behaviors and mood-related factors in adults with overweight during weight loss: a randomized controlled trial

    • 2022-06-17
    • RCT · n = 152
    • Nutritional Neuroscience 26(7)
    • • B. Choi
      • Lucie Brunelle
      • G. Pilon
      • Brunella Gonzalez Cautela
      • T. Tompkins
      • V. Drapeau
      • A. Marette
      • A. Tremblay

    • PubMed: 35714163
    • DOI: 10.1080/1028415X.2022.2081288

    14 Insights on

    • Improved Insulin Sensitivity
    • Reduced Low-Density Lipoprotein Level
    • Reduced Body Weight
    • Reduced Triglyceride Levels
    • Reduced LDL Cholesterol
    • Reduced Body Fat Mass
    • Reduced Insulin Levels
    • Improved Eating Behaviors
    • Reduced Binge Eating Tendencies
    • Reduced Food Cravings
    • Reduced Disinhibition
    • Reduced HOMA-IR
    • Reduced Binge Eating Tendency
    • Reduced Food Craving

    • High evidence
• June 19

  • Development of an Antibacterial Dentin Adhesive.

    • 2022-06-19
    • Polymers 14(12)
    • • Stephanie R Lopes
      • Amanda G N Matuda
      • Raquel P Campos
      • Ana Paula V P Mafetano
      • Ana Helena M Barnabe
      • Gabriela S Chagas
      • Daphne C Barcellos
      • Li-Na Niu
      • Franklin R Tay
      • Cesar R Pucci

    • PubMed: 35746077
    • DOI: 10.3390/polym14122502

    3 Insights on

    • Reduced Oral Bacteria Growth
    • Preserved Dentin Bond Strength
    • Reduced Conversion Rate

    • Low evidence

  • Gut immune homeostasis: the immunomodulatory role of Bacillus clausii, from basic to clinical evidence

    • 2022-06-19
    • Review
    • Expert Review of Clinical Immunology 18(7)
    • • R. Wong-Chew
      • Jo-Anne A de Castro
      • L. Morelli
      • Marcos Perez
      • M. Ozen

    • PubMed: 35674642
    • DOI: 10.1080/1744666X.2022.2085559

    1 Insight on

    • Improved Intestinal Defense

    • Low evidence
• June 21

  • Lactococcus lactis NCDO2118 exerts visceral antinociceptive properties in rat via GABA production in the gastro-intestinal tract

    • 2022-06-21
    • Clinical Trial
    • eLife 11
    • • V. Laroute
      • C. Beaufrand
      • Pedro Gomes
      • S. Nouaille
      • V. Tondereau
      • M. Daveran-Mingot
      • V. Théodorou
      • H. Eutamene
      • M. Mercier-Bonin
      • M. Cocaign-Bousquet

    • PubMed: 35727704
    • DOI: 10.7554/eLife.77100

    1 Insight on

    • Reduced Visceral Hypersensitivity

    • Low evidence
    • Rigorous Journal
    • Animal Study
• June 22

  • How Microbiomes Affect Skin Aging: The Updated Evidence and Current Perspectives.

    • 2022-06-22
    • Review
    • Life (Basel, Switzerland) 12(7)
    • • Yanisa Ratanapokasatit
      • Wannada Laisuan
      • Teerapong Rattananukrom
      • Aisawan Petchlorlian
      • Iyarit Thaipisuttikul
      • Mongkhon Sompornrattanaphan

    • PubMed: 35888025
    • DOI: 10.3390/life12070936

    2 Insights on

    • Improved Skin Hydration
    • Reduced Transepidermal Water Loss

    • Low evidence

  • Probiotics and their beneficial effects on alcohol-induced liver injury in a rat model: the role of fecal microbiota.

    • 2022-06-22
    • BMC complementary medicine and therapies 22(1)
    • • Maneerat Chayanupatkul
      • Kanjana Somanawat
      • Natthaya Chuaypen
      • Naruemon Klaikeaw
      • Natcha Wanpiyarat
      • Prasong Siriviriyakul
      • Somying Tumwasorn
      • Duangporn Werawatganon

    • PubMed: 35733194
    • DOI: 10.1186/s12906-022-03643-9

    6 Insights on

    • Improved Gut Microbiota Diversity
    • Improved Gut Microbiota Composition
    • Reduced Inflammatory Markers
    • Reduced Inflammation
    • Reduced Oxidative Stress
    • Reduced Alcohol-Induced Liver Injury

    • Low evidence
    • Animal Study

  • Lactobacillus reuteri J1 prevents obesity by altering the gut microbiota and regulating bile acid metabolism in obese mice.

    • 2022-06-22
    • Clinical Trial
    • Food & Function 13(12)
    • • Chenxi Zhang
      • Ru-Ying Fang
      • Xing Lu
      • Yu Zhang
      • Mo Yang
      • Yue Su
      • Yujun Jiang
      • C. Man

    • PubMed: 35647914
    • DOI: 10.1039/d1fo04387k

    10 Insights on

    • Improved Insulin Sensitivity
    • Reduced Body Fat Mass
    • Prevention of Weight Gain
    • Improved Glucose Regulation
    • Induction of Browning of White Adipose Tissue
    • Improved Dyslipidemia
    • Improved Bile Acid Metabolism
    • Reduced Hepatic Triglyceride Levels
    • Improved Adipose Browning
    • Altered Bile Acid Composition

    • Low evidence
    • Animal Study

  • Production and Shelf-Life Study of Probiotic Caja (Spondias mombin L.) Pulp Using Bifidobacterium animalis ssp. Lactis B94

    • 2022-06-22
    • Foods 11(13)
    • • T. Rodrigues
      • Aline Pacheco Albuquerque
      • Antônio Vinícius Silva de Azevedo
      • L. Silva
      • Matheus Pasquali
      • G. T. D. Araújo
      • S. S. Monteiro
      • Wanessa Dayane Leite Lima
      • A. P. T. Rocha

    • PubMed: 35804654
    • DOI: 10.3390/foods11131838

    1 Insight on

    • Improved Gut Microbiota Growth Medium Suitability

    • Low evidence
    • Rigorous Journal
• June 24

  • Lactococcus lactis KF140 Reduces Dietary Absorption of Nε - (Carboxymethyl)lysine in Rats and Humans via β-Galactosidase Activity

    • 2022-06-24
    • Clinical Trial · n = 12
    • Frontiers in Nutrition 9
    • • Ho‐Young Park
      • Hye-Bin Lee
      • So-Young Lee
      • Mi-Jin Oh
      • S. Ha
      • Eunju Do
      • H. H. L. Lee
      • J. Hur
      • Kwang-Won Lee
      • Mi-hyun Nam
      • M. Park
      • Yoonsook Kim

    • PubMed: 35811971
    • DOI: 10.3389/fnut.2022.916262

    6 Insights on

    • Reduced Serum Carboxymethyl-Lysine Levels
    • Reduced Serum Levels of CML
    • Fecal Contamination
    • Inhibited Absorption of Advanced Glycation End-products (AGEs)
    • Prevented Increase in Serum CML Levels
    • Reduced Hepatic CML Absorption

    • Low evidence
    • Animal Study
• June 26

  • Effects of Probiotics Supplementation on Gastrointestinal Symptoms in Athletes: A Systematic Review of Randomized Controlled Trials.

    • 2022-06-26
    • Systematic Review
    • Nutrients 14(13)
    • • Karolina Łagowska
      • Joanna Bajerska
      • Szymon Kamiński
      • Cristian Del Bo'

    • PubMed: 35807826
    • DOI: 10.3390/nu14132645

    1 Insight on

    • Improved Gastrointestinal Symptoms

    • High evidence
    • Rigorous Journal
• June 27

  • Bacillus subtilis Produces Amino Acids to Stimulate Protein Synthesis in Ruminal Tissue Explants via the Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta–Serine/Threonine Kinase–Mammalian Target of Rapamycin Complex 1 Pathway

    • 2022-06-27
    • Frontiers in Veterinary Science 9
    • • Qiuju Wang
      • Yulong Ren
      • Yizhe Cui
      • Bingnan Gao
      • Hao Zhang
      • Q. Jiang
      • J. Loor
      • Z. Deng
      • Chuang Xu

    • PubMed: 35832333
    • DOI: 10.3389/fvets.2022.852321

    1 Insight on

    • Enhanced Protein Synthesis

    • Low evidence
• June 28

  • Effect of Probiotic Bifidobacterium breve in Improving Cognitive Function and Preventing Brain Atrophy in Older Patients with Suspected Mild Cognitive Impairment: Results of a 24-Week Randomized, Double-Blind, Placebo-Controlled Trial

    • 2022-06-28
    • RCT · n = 130
    • Journal of Alzheimer's Disease 88(1)
    • • D. Asaoka
      • Jinzhong Xiao
      • T. Takeda
      • N. Yanagisawa
      • Takahiro Yamazaki
      • Yoichiro Matsubara
      • Hideki Sugiyama
      • Noemi Endo
      • Motoyuki Higa
      • K. Kasanuki
      • Y. Ichimiya
      • S. Koido
      • Kazuya Ohno
      • François Bernier
      • N. Katsumata
      • A. Nagahara
      • H. Arai
      • T. Ohkusa
      • Nobuhiro Sato

    • PubMed: 35570493
    • DOI: 10.3233/jad-220148

    4 Insights on

    • Improved Cognitive Function
    • Reduced Brain Atrophy
    • Improved Cognitive Orientation Function
    • Improved Orientation in Time (MMSE Subscale)

    • High evidence
    • Rigorous Journal

  • Effect of Different Nutritional Supplements on Glucose Response of Complete Meals in Two Crossover Studies.

    • 2022-06-28
    • RCT
    • Nutrients 14(13)
    • • Nele Gheldof
      • Celia Francey
      • Andreas Rytz
      • Léonie Egli
      • Frederik Delodder
      • Lionel Bovetto
      • Nathalie Piccardi
      • Christian Darimont

    • PubMed: 35807854
    • DOI: 10.3390/nu14132674

    1 Insight on

    • Reduced Postprandial Glucose Response

    • High evidence
    • Rigorous Journal

  • Probiotics Surface-Delivering Fiber2 Protein of Fowl Adenovirus 4 Stimulate Protective Immunity Against Hepatitis-Hydropericardium Syndrome in Chickens.

    • 2022-06-28
    • Clinical Trial
    • Frontiers in immunology 13
    • • Zhipeng Jia
      • Xinghui Pan
      • Wenjing Zhi
      • Hang Chen
      • Bingrong Bai
      • Chunli Ma
      • Dexing Ma

    • PubMed: 35837390
    • DOI: 10.3389/fimmu.2022.919100

    1 Insight on

    • Improved Immune Response to Adenovirus

    • Low evidence
    • Animal Study
• June 29

  • Bifidobacterium lactis TY-S01 Prevents Loperamide-Induced Constipation by Modulating Gut Microbiota and Its Metabolites in Mice.

    • 2022-06-29
    • Frontiers in nutrition 9
    • • Tian Tang
      • Jing Wang
      • Yuanyuan Jiang
      • Xu Zhu
      • Zhen Zhang
      • Yuying Wang
      • Xi Shu
      • Yadan Deng
      • Feng Zhang

    • PubMed: 35845767
    • DOI: 10.3389/fnut.2022.890314

    5 Insights on

    • Improved Gut Microbiota Composition
    • Increased Short-Chain Fatty Acid Production
    • Reduced Gut Inflammation
    • Improved Constipation
    • Improved Gut Barrier Function

    • Low evidence

  • Effects of Four Weeks of Beta-Alanine Supplementation Combined with One Week of Creatine Loading on Physical and Cognitive Performance in Military Personnel.

    • 2022-06-29
    • RCT · n = 10
    • International journal of environmental research and public health 19(13)
    • • Mohammad Samadi
      • Ali Askarian
      • Hossein Shirvani
      • Alireza Shamsoddini
      • Abolfazl Shakibaee
      • Scott C Forbes
      • Mojtaba Kaviani

    • PubMed: 35805647
    • DOI: 10.3390/ijerph19137992

    9 Insights on

    • Increased Butyrate Levels
    • Improved Cognitive Function
    • Reduced Lactate Levels
    • Improved Vertical Jump Performance
    • Improved Physical Performance
    • Increased Testosterone Level
    • Reduced Cortisol Level
    • Improved Mathematical Processing
    • Improved Muscular Strength

    • High evidence

  • Limosilactobacillus reuteri SLZX19-12 Protects the Colon from Infection by Enhancing Stability of the Gut Microbiota and Barrier Integrity and Reducing Inflammation

    • 2022-06-29
    • Clinical Trial
    • Microbiology Spectrum 10(3)
    • • Jianmin Wu
      • Zi-Xue Lin
      • Xian Wang
      • Ying Zhao
      • Jinbiao Zhao
      • Hu Liu
      • L. Johnston
      • Lin Lu
      • Xi Ma

    • PubMed: 35658572
    • DOI: 10.1128/spectrum.02124-21

    3 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Colonic Inflammation
    • Improved Stability of Gut Microbiota

    • Low evidence
    • Animal Study

  • Effect and Mechanism of Bifidobacterium animalis B94 in the Prevention and Treatment of Liver Injury in Rats

    • 2022-06-29
    • RCT · n = 12
    • Frontiers in Cellular and Infection Microbiology 12
    • • Tianfang Zhang
      • Jie Wang
      • Zhao Yao
      • Lingmei Ni
      • Yifan Zhao
      • Shuang Wei
      • Zuobing Chen

    • PubMed: 35846768
    • DOI: 10.3389/fcimb.2022.914684

    3 Insights on

    • Improved Liver Function
    • Reduced Intestinal Damage
    • Altered Gut Metabolome

    • Low evidence
    • Animal Study
• June 30

  • Acylation, a Conductor of Ghrelin Function in Brain Health and Disease.

    • 2022-06-30
    • Review
    • Frontiers in physiology 13
    • • Alanna S Thomas
      • Martina Sassi
      • Roberto Angelini
      • Alwena H Morgan
      • Jeffrey S Davies

    • PubMed: 35845996
    • DOI: 10.3389/fphys.2022.831641

    3 Insights on

    • Improved Sleep Quality
    • Improved Appetite
    • Reduced Fatigue

    • Low evidence

  • Lactobacillus paracasei CCFM1223 Protects against Lipopolysaccharide-Induced Acute Liver Injury in Mice by Regulating the “Gut–Liver” Axis

    • 2022-06-30
    • Clinical Trial
    • Microorganisms 10(7)
    • • Weiling Guo
      • Bingyong Mao
      • Xin Tang
      • Qiuxiang Zhang
      • Jianxin Zhao
      • Shumao Cui
      • Hao Zhang

    • PubMed: 35889040
    • DOI: 10.3390/microorganisms10071321

    6 Insights on

    • Reduced Pro-inflammatory Cytokine Levels
    • Reduced Liver Enzyme Levels
    • Improved Antioxidative Enzyme Activities
    • Improved Beneficial Intestinal Microbiota
    • Reduced Harmful Gut Microbiota
    • Elevated IL-22 Levels

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Oral Lactobacillus fermentum CECT5716 in the patients with lactational abscess treated by needle aspiration: The late follow-up of a randomized controlled trial

    • 2022-06-30
    • RCT · n = 101
    • Medicine 101(26)
    • • Yi Zhang
      • Ya-jun Gao
      • Xiang-ping He
      • Song-tao Ding
      • Hai-fen Gao

    • PubMed: 35777008
    • DOI: 10.1097/MD.0000000000029761

    8 Insights on

    • Reduced Occurrence of Mastitis
    • Reduced Risk of Breastfeeding Cessation Due to Mastitis Recurrence
    • Reduced Rate of Stopping Breastfeeding
    • Reduced Pain During Lactation
    • Reduced Cessation of Breastfeeding Due to Mastitis Recurrence
    • Reduced Breastfeeding Cessation
    • Relieved Breast Pain
    • Reduced Mastitis Recurrence

    • High evidence
• Undated – 4 supplement studies

  • Morus Alba leaf extract affects metabolic profiles, biomarkers inflammation and oxidative stress in patients with type 2 diabetes mellitus: A double-blind clinical trial.

    • 2022-06
    • RCT · n = 60
    • Clinical nutrition ESPEN 49
    • • Mohsen Taghizadeh
      • Azam Mohammad Zadeh
      • Zatollah Asemi
      • Amir Hosein Farrokhnezhad
      • Mohammad Reza Memarzadeh
      • Zarin Banikazemi
      • Mohammad Shariat
      • Rana Shafabakhsh

    • PubMed: 35623877
    • DOI: 10.1016/j.clnesp.2022.03.027

    10 Insights on

    • Improved Insulin Sensitivity
    • Reduced Total Cholesterol Levels
    • Reduced Low-Density Lipoprotein Level
    • Reduced Triglyceride Levels
    • Improved Insulin Levels
    • Increased HDL Cholesterol Levels
    • Reduced Liver Enzyme Levels
    • Reduced Fasting Blood Glucose
    • Reduced Malondialdehyde Level
    • Reduced Pro-inflammatory Biomarker Level

    • High evidence

  • N-acetyl cysteine in the treatment of cannabis use disorder: A systematic review of clinical trials.

    • 2022-06
    • Systematic Review
    • Addictive behaviors 129
    • • Rishi Sharma
      • Sai Krishna Tikka
      • Ashish Ramesh Bhute
      • Binaya Kumar Bastia

    • PubMed: 35189496
    • DOI: 10.1016/j.addbeh.2022.107283

    3 Insights on

    • Reduced Cannabis Use
    • Reduced Cannabis Craving
    • Improved Medication Adherence

    • High evidence

  • Effects of Pueraria mirifica on vaginal artery vascularization in postmenopausal women with genitourinary syndrome of menopause.

    • 2022-06
    • RCT
    • Maturitas 160
    • • Patsira Warinsiriruk
      • Chananya Tantitham
      • Wichai Cherdshewasart
      • S Abbas Shobeiri
      • Jittima Manonai

    • PubMed: 35550707
    • DOI: 10.1016/j.maturitas.2022.01.005

    4 Insights on

    • Reduced Pulsatility Index
    • Reduced Resistance Index
    • Increased Vaginal Maturation Index
    • Increased Vaginal Health Index

    • High evidence

  • The effect of the probiotic consortia on SARS-CoV-2 infection in ferrets and on human immune cell response in vitro.

    • 2022-06
    • iScience 25(6)
    • • Markus J Lehtinen
      • Ritesh Kumar
      • Bryan Zabel
      • Sanna M Mäkelä
      • Derek Nedveck
      • Peipei Tang
      • Sinikka Latvala
      • Sebastien Guery
      • Charles R Budinoff

    • PubMed: 35634575
    • DOI: 10.1016/j.isci.2022.104445

    2 Insights on

    • Reduced Viral Load
    • Modulated Immune Response

    • Low evidence