March 2025 Supplement Research Papers

• March 1

  • Malate or Not? Acute Effects of L-Citrulline Versus Citrulline Malate on Neuromuscular Performance in Young, Trained Adults: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial.

    • 2025-03-01
    • RCT · n = 21
    • International journal of sport nutrition and exercise metabolism 35(2)
    • • Juan J Martín-Olmedo
      • Sergio Miras-Moreno
      • Kevin Cuadra-Montes
      • Amador García-Ramos
      • Jonatan R Ruiz
      • Lucas Jurado-Fasoli

    • PubMed: 39662304
    • DOI: 10.1123/ijsnem.2024-0006

    9 Insights on

    • Improved Strength Endurance
    • Improved Upper Limb Maximal Neuromuscular Performance
    • Improved Lower Limb Maximal Neuromuscular Performance
    • Improved Ballistic Strength
    • Improved Strength-Endurance Mean Velocity
    • Reduced Exertion Perception
    • Improved Maximal Neuromuscular Performance
    • Improved Emotional Perception
    • Improved Exertion and Emotional Perceptions

    • High evidence

  • Post-Exercise Hypotension after Exercising in Hypoxia with and Without Tart Cherry Supplementation.

    • 2025-03-01
    • RCT
    • High altitude medicine & biology 26(1)
    • • Masahiro Horiuchi
      • Samuel J Oliver

    • PubMed: 39545270
    • DOI: 10.1089/ham.2024.0076

    2 Insights on

    • Reduced Mean Arterial Pressure
    • Improved Cardiac Baroreflex Sensitivity

    • High evidence

  • Exploring the Effects of a Calming Herbal Tea Blend on Perioperative Anxiety: A Randomized Clinical Trial.

    • 2025-03-01
    • RCT · n = 210
    • Journal of medicinal food 28(3)
    • • Victória Cosel Zampieri
      • Itamar Luís Gonçalves
      • Ana Luiza Lira
      • Jamile Zeni
      • Geciane Toniazzo Backes
      • André Keng Wei Hsu

    • PubMed: 39514279
    • DOI: 10.1089/jmf.2024.0170

    1 Insight on

    • Reduced Anxiety

    • High evidence
    • Large Human Trial
• March 2

  • Where Biology Meets Engineering: Scaling Up Microbial Nutraceuticals to Bridge Nutrition, Therapeutics, and Global Impact.

    • 2025-03-02
    • Review
    • Microorganisms 13(3)
    • • Ahmed M Elazzazy
      • Mohammed N Baeshen
      • Khalid M Alasmi
      • Shatha I Alqurashi
      • Said E Desouky
      • Sadat M R Khattab

    • PubMed: 40142459
    • DOI: 10.3390/microorganisms13030566

    1 Insight on

    • Improved Intestinal Function

    • Low evidence
• March 3

  • The Impact of Testosterone Therapy on the Vaginal Microbiota of Transgender Men and Nonbinary People: A Prospective Study.

    • 2025-03-03
    • Observational
    • The Journal of infectious diseases 232(3)
    • • Olivia T Van Gerwen
      • Kristal J Aaron
      • Emma Sophia Kay
      • Krishmita Siwakoti
      • Angela Pontius
      • Saralyn Richter
      • Z Alex Sherman
      • Keonte J Graves
      • Ashutosh Tamhane
      • Jacob H Elnaggar
      • Meng Luo
      • Evelyn Toh
      • David E Nelson
      • Nicholas J Van Wagoner
      • Christopher M Taylor
      • Christina A Muzny

    • PubMed: 40037329
    • DOI: 10.1093/infdis/jiaf114

    1 Insight on

    • No Human Health Outcome Reported

    • Low evidence

  • Lactobacillus reuteri protectis DSM 17938 at high doses versus placebo in children with acute gastroenteritis in a Pediatric Emergency Department.

    • 2025-03-03
    • RCT
    • Journal of pediatric gastroenterology and nutrition 80(5)
    • • Ricardo Iramain
      • Alfredo Jara
      • Jorge Ortiz
      • Laura Cardozo
      • Rocío Morinigo

    • PubMed: 40026275
    • DOI: 10.1002/jpn3.70026

    1 Insight on

    • Reduced Diarrhea Rate

    • High evidence

  • Therapeutic Value of Lactobacillus gasseri 345A in Chronic Constipation.

    • 2025-03-03
    • RCT · n = 40
    • Neurogastroenterology and motility 37(5)
    • • Stefan Roos
      • Atti-La Dahlgren
      • Yu-Kang Mao
      • Anton Pallin
      • Andrew M Stanisz
      • Paul Forsythe
      • Wolfgang Kunze
      • Per M Hellström

    • PubMed: 40033155
    • DOI: 10.1111/nmo.70012

    9 Insights on

    • Improved Bowel Movement Frequency
    • Improved Stool Consistency
    • Reduced Abdominal Pain
    • Improved Intestinal Motility
    • Increased Complete Spontaneous Bowel Movements
    • Improved Rectal Emptying
    • Reduced Time Spent for Defecation
    • Reduced Rescue Laxative Use
    • Improved Sex Life

    • High evidence

  • Lactobacillus plantae Expressing Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Single-Chain Antibody Can Inhibit PRRSV Replication and Change the Intestinal Flora Structure of Piglets.

    • 2025-03-03
    • International journal of molecular sciences 26(5)
    • • Tianming Niu
      • Tianqi Fan
      • Yingjie Wang
      • Kuipeng Gao
      • Jinhui Zhao
      • Ruyu Wang
      • Xiaolei Chen
      • Junhong Xing
      • Jingjing Qiu
      • Boshi Zou
      • Shuhui Fan
      • Shi Zhang
      • Qiong Wu
      • Guilian Yang
      • Nan Wang
      • Yan Zeng
      • Xin Cao
      • Yanlong Jiang
      • Jianzhong Wang
      • Haibin Huang
      • Wentao Yang
      • Chunwei Shi
      • Zhipeng Li
      • Chunfeng Wang

    • PubMed: 40076879
    • DOI: 10.3390/ijms26052257

    6 Insights on

    • Improved Immune Function
    • Reduced RSV Replication
    • Reduced Disease Symptoms
    • Reduced Viral Infection
    • Increased CD3+CD8+ Cell Counts
    • Improved Clinical Protection Against Viral Challenge

    • Low evidence
    • Rigorous Journal
    • Animal Study
• March 4

  • Effect of Daily Avocado Intake on Cardiovascular Health Assessed by Life's Essential 8: An Ancillary Study of HAT, a Randomized Controlled Trial.

    • 2025-03-04
    • RCT · n = 969
    • Journal of the American Heart Association 14(5)
    • • Janhavi J Damani
      • Penny M Kris-Etherton
      • Alice H Lichtenstein
      • Nirupa R Matthan
      • Joan Sabaté
      • Zhaoping Li
      • David Reboussin
      • Kristina S Petersen

    • PubMed: 39968784
    • DOI: 10.1161/jaha.124.039130

    4 Insights on

    • Improved Blood Lipid Profile
    • Improved Diet Quality
    • Improved Life's Essential 8 Score
    • Improved Sleep Health

    • High evidence
    • Large Human Trial
• March 5

  • Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis.

    • 2025-03-05
    • Meta-Analysis
    • BMC complementary medicine and therapies 25(1)
    • • Samar A Amer
      • Dina Essam Abo-Elnour
      • Abdallah Abbas
      • Abdelrahman Salah Abdelrahman
      • Hossam-Eldin Mohamed Hamdy
      • Samar Kenawy
      • Menna M Sarhan
      • Omar Hany Mohamed
      • Mohamed Yousif Elnaghy
      • Mohammed Baker
      • Rawan Medhat El-Gayar
      • Omnia Samy El-Sayed
      • Moamen Mostafa Asla

    • PubMed: 40045266
    • DOI: 10.1186/s12906-025-04809-x

    3 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure
    • Reduced Pulse Rate

    • High evidence

  • Research in etiology of Floppy Kid Syndrome.

    • 2025-03-05
    • Observational
    • Frontiers in veterinary science 12
    • • Cheng Cheng
      • Yan Zheng
      • Xin Wang
      • Jianping Tao
      • Darong Cheng

    • PubMed: 40110433
    • DOI: 10.3389/fvets.2025.1557951

    2 Insights on

    • Reduced Dysbiosis
    • Reduced Pathogen Growth

    • Low evidence

  • Impact of Vitamin D3 on Postorthodontic Treatment Stability: A Randomized Controlled Trial.

    • 2025-03-05
    • RCT
    • The journal of contemporary dental practice 25(12)
    • • Thrivikhraman Kothandaraman
      • Prema Anbarasu
      • Sp Saravana Dinesh
      • Saravana Kumar Subramanian
      • Gabriel Eisenhuth
      • Sebastian Eisenhuth
      • Claudia Eisenhuth

    • PubMed: 40079995
    • DOI: 10.5005/jp-journals-10024-3795

    4 Insights on

    • Reduced Orthodontic Relapse
    • Reduced Inter-canine Width
    • Reduced Arch Perimeter Change
    • Reduced Intermolar Width Change

    • High evidence

  • Efficacy of ginkgo biloba extract in the treatment of idiopathic pulmonary fibrosis: a systematic review and meta-analysis of randomized controlled trials.

    • 2025-03-05
    • Review · n = 1,043
    • Frontiers in pharmacology 16
    • • Xuxin Sun
      • Ling Peng
      • Wenchao Xiao
      • Keying Li
      • Sheng Chen

    • PubMed: 40110130
    • DOI: 10.3389/fphar.2025.1524505

    11 Insights on

    • Reduced Interleukin-4 Levels
    • Improved Treatment Response Rate
    • Improved Forced Vital Capacity
    • Improved Arterial Oxygen Partial Pressure
    • Improved Arterial Oxygen Saturation
    • Reduced Carbon Dioxide Partial Pressure
    • Improved Forced Expiratory Volume in One Second
    • Improved Maximum Voluntary Ventilation
    • Improved Six-Minute Walk Test
    • Reduced Hyaluronan Level
    • Reduced Laminin Level

    • High evidence
• March 6

  • Microbial-Derived Antioxidants in Intestinal Inflammation: A Systematic Review of Their Therapeutic Potential.

    • 2025-03-06
    • Review
    • Antioxidants (Basel, Switzerland) 14(3)
    • • María José García Mansilla
      • María Jesús Rodríguez Sojo
      • Andreea Roxana Lista
      • Ciskey Vanessa Ayala Mosqueda
      • Antonio Jesús Ruiz Malagón
      • Ailec Ho Plagaro
      • Julio Gálvez
      • Alba Rodríguez Nogales
      • María José Rodríguez Sánchez

    • PubMed: 40227262
    • DOI: 10.3390/antiox14030321

    1 Insight on

    • Reduced Intestinal Inflammation

    • Low evidence

  • Effectiveness of acupoint injection combined with specific electromagnetic spectrum irradiation and acupuncture on peripheral facial paralysis.

    • 2025-03-06
    • RCT · n = 85
    • Neurological research 47(5)
    • • Meihua Sun
      • Mingli Ge
      • Qinglin Shen

    • PubMed: 40050238
    • DOI: 10.1080/01616412.2025.2476515

    7 Insights on

    • Reduced Interleukin-6 Levels
    • Reduced Interleukin-1β Levels
    • Improved Cure Rate
    • Reduced Tumor Necrosis Factor-alpha Level
    • Improved Portmann Score
    • Improved House-Brackmann Grade
    • Shortened Cure Time

    • High evidence

  • Cardioprotective Effect of Nigella sativa in Pediatric Patients with Type 1 Diabetes Mellitus: A Randomized Controlled Study.

    • 2025-03-06
    • RCT · n = 30
    • Paediatric drugs 27(4)
    • • Dalia El-Afify
      • Doaa El Amrousy

    • PubMed: 40048139
    • DOI: 10.1007/s40272-025-00687-5

    9 Insights on

    • Reduced Total Cholesterol Levels
    • Reduced Low-Density Lipoprotein Level
    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Transforming Growth Factor Beta Levels
    • Reduced Malondialdehyde Level
    • Reduced Nitric Oxide Level
    • Reduced Troponin I Level
    • Improved Left Ventricular Global Longitudinal Strain
    • Improved Left Ventricular E'/A' Ratio

    • High evidence
• March 7

  • Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients.

    • 2025-03-07
    • RCT · n = 163
    • Journal of translational medicine 23(1)
    • • Huai Heng Loh
      • Siow Phing Tay
      • Ai Jiun Koa
      • Mei Ching Yong
      • Asri Said
      • Chee Shee Chai
      • Natasya Marliana Abdul Malik
      • Anselm Ting Su
      • Bonnie Bao Chee Tang
      • Florence Hui Sieng Tan
      • Norlela Sukor

    • PubMed: 40055713
    • DOI: 10.1186/s12967-025-06312-w

    18 Insights on

    • Reduced Waist Circumference
    • Reduced Body Mass Index
    • Improved Quality of Life
    • Reduced Body Weight
    • Reduced Uric Acid Levels
    • Reduced Hemoglobin A1c
    • Improved Metabolic Parameters
    • Improved Blood Lipid Profile
    • Improved Heart Rate Variability
    • Reduced hsCRP Level
    • Improved Quality of Life Score
    • Reduced Nocturnal Heart Rate
    • Improved Epworth Sleepiness Scale
    • Improved Epworth Sleepiness Scale Score
    • Reduced Steatotic Liver Disease Grade
    • Reduced Aldosterone Level
    • Reduced Renin Level
    • Improved Flow-Mediated Dilatation

    • High evidence
    • Large Human Trial

  • The Impact of Rhodiola Rosea Extract on Strength Performance in Alternative Bench-Press and Bench-Pull Exercises Under Resting and Mental Fatigue Conditions: A Randomized, Triple-Blinded, Placebo-Controlled, Crossover Trial.

    • 2025-03-07
    • RCT
    • Nutrients 17(6)
    • • Daniel Marcos-Frutos
      • Žiga Leban
      • Zhaoqian Li
      • Xing Zhang
      • Paula M Lara
      • Carlos Alix-Fages
      • Pablo Jiménez-Martínez
      • Nadia Zebboudji
      • Annabelle Caillet
      • Beatriz Redondo
      • Jesús Vera
      • Danica Janicijevic
      • Amador García-Ramos

    • PubMed: 40289957
    • DOI: 10.3390/nu17060940

    6 Insights on

    • Improved Strength Performance
    • Reduced Perceived Exertion
    • Reduced Mental Fatigue
    • Improved Visuo-Cognitive Processing
    • Increased Bench Press Repetition
    • Increased Bench Pull Velocity

    • High evidence
    • Rigorous Journal

  • Unraveling the role of the gut microbiome in pregnancy disorders: insights and implications.

    • 2025-03-07
    • Review
    • Frontiers in cellular and infection microbiology 15
    • • Yupei Xie
      • Qian Chen
      • Dan Shan
      • Xiongfei Pan
      • Yayi Hu

    • PubMed: 40125520
    • DOI: 10.3389/fcimb.2025.1521754

    1 Insight on

    • Reduced Pregnancy Disorder Risk

    • Low evidence

  • Effect of Nigella sativa-L supplementation on glycemia in adolescent polycystic ovarian syndrome: secondary analysis of a randomized controlled trial study.

    • 2025-03-07
    • RCT
    • Journal of ovarian research 18(1)
    • • Azamsadat Mahmoudian
      • Akram Ashouri
      • Fatemeh Mohammadzadeh
      • Roghaieh Rahmani Bilandi
      • Sareh Dashti
      • Narjes Bahri

    • PubMed: 40055705
    • DOI: 10.1186/s13048-025-01634-1

    3 Insights on

    • Improved Fasting Plasma Glucose
    • Reduced Postprandial Glucose
    • Reduced Two-Hour Postprandial Glucose

    • High evidence
• March 8

  • Evaluating the anti-inflammatory and antioxidant efficacy of complementary and alternative medicines (CAM) used for management of inflammatory bowel disease: a comprehensive review.

    • 2025-03-08
    • Review
    • Redox report : communications in free radical research 30(1)
    • • Sia Shin
      • Siqi Chen
      • Kangzhe Xie
      • Suehad Abou Duhun
      • Tamara Ortiz-Cerda

    • PubMed: 40056427
    • DOI: 10.1080/13510002.2025.2471737

    3 Insights on

    • Improved Gut Microbiota
    • Improved Total Antioxidant Status
    • Reduced Inflammation

    • Low evidence
• March 10

  • Effective probiotic regimens for bacterial vaginosis treatment and recurrence prevention: A systematic review.

    • 2025-03-10
    • Systematic Review
    • Narra J 5(1)
    • • Udjianto Udjianto
      • Noorhamdani A Sirat
      • Bambang Rahardjo
      • Lilik Zuhriyah

    • PubMed: 40352249
    • DOI: 10.52225/narra.v5i1.1671

    3 Insights on

    • Reduced Recurrence of Bacterial Vaginosis
    • Improved Symptoms of Bacterial Vaginosis
    • Improved Vaginal pH

    • High evidence
• March 11

  • Efficacy and safety of gastrodin in preventing postoperative delirium following cardiac surgery: a randomized placebo controlled clinical trial.

    • 2025-03-11
    • RCT
    • Critical care (London, England) 29(1)
    • • Yun-Xiao Bai
      • Hui-Liang Wu
      • Wan-Li Xie
      • Xia Li
      • Jing-Jing Han
      • Jie Liu
      • Shi-Qiang Chen
      • Ping Yin
      • Nian-Guo Dong
      • Qing-Ping Wu

    • PubMed: 40069830
    • DOI: 10.1186/s13054-025-05331-9

    3 Insights on

    • Reduced Postoperative Delirium Incidence
    • Reduced Postoperative Cognitive Dysfunction Incidence
    • Improved Hospital Discharge

    • High evidence

  • Antioxidants for the management of oral leukoplakia: A systematic review of randomized controlled trials.

    • 2025-03-11
    • Review · n = 1,147
    • Journal of oral biology and craniofacial research 15(3)
    • • Divya Gopinath
      • Sara Ibrahim Waki
      • Kwok Fu Cheah
      • Swagatika Panda

    • PubMed: 40144648
    • DOI: 10.1016/j.jobcr.2025.03.001

    1 Insight on

    • Reduced Lesion Size

    • High evidence

  • Cardiometabolic Effects of Nigella sativa in Postmenopausal Women with Hypertension: A Prospective, Observational, Pilot Study.

    • 2025-03-11
    • Observational · n = 52
    • Nutrients 17(6)
    • • Barbara Pala
      • Giulia Nardoianni
      • Paola Gualtieri
      • Giulia Frank
      • Marco Alfonso Perrone
      • Laura Di Renzo
      • Giuliano Tocci

    • PubMed: 40338252
    • DOI: 10.3390/nu17060985

    7 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Body Mass Index
    • Reduced Systolic Blood Pressure
    • Reduced Body Weight
    • Improved Blood Lipid Profile
    • Reduced Heart Rate
    • Improved Climacteric Symptom

    • High evidence
    • Rigorous Journal
• March 12

  • Effectiveness of Probiotics, Prebiotics, and Symbiotic Supplementation in Cystic Fibrosis Patients: A Systematic Review and Meta-Analysis of Clinical Trials.

    • 2025-03-12
    • Meta-Analysis
    • Medicina (Kaunas, Lithuania) 61(3)
    • • Freiser Eceomo Cruz Mosquera
      • Claudia Lorena Perlaza
      • Anisbed Naranjo Rojas
      • Saray Murillo Rios
      • Alejandra Carrero Gallego
      • Sara Isabel Fischersworring
      • Juan Sebastián Rodríguez
      • Yamil Liscano

    • PubMed: 40142300
    • DOI: 10.3390/medicina61030489

    6 Insights on

    • Reduced Pro-Inflammatory Cytokines
    • Improved Quality of Life
    • Reduced Faecal Calprotectin
    • Reduced Hospitalization Rate
    • Improved Lung Function
    • Reduced Exacerbation Frequency

    • High evidence

  • Effects of Guarana and Green Tea Consumption on Students' Intellectual Performances.

    • 2025-03-12
    • Clinical Trial
    • Nutrients 17(6)
    • • Valentina Amaritei
      • Petronela-Elena Buruiana
      • Roxana Filip
      • Florin Filip
      • Ancuta Veronica Lupaescu
      • Monica Iavorschi
      • Roxana-Elena Gheorghita

    • PubMed: 40290036
    • DOI: 10.3390/nu17061000

    1 Insight on

    • Improved Memory Function

    • High evidence
    • Rigorous Journal
• March 13

  • Multidisciplinary Integrative Medicine Approach for Cancer Patients: A Multicenter Retrospective Study.

    • 2025-03-13
    • Clinical Trial · n = 54
    • Nutrients 17(6)
    • • Massimiliano Berretta
      • Vincenzo Quagliariello
      • Alessandro Ottaiano
      • Mariachiara Santorsola
      • Raffaele Di Francia
      • Patrizia Carroccio
      • Nicola Maurea
      • Oreste Claudio Buonomo
      • Gaetano Facchini
      • Giordana Di Mauro
      • Monica Montopoli
      • Enrica Toscano
      • Claudia Gelsomino
      • Antonio Picone
      • Tindara Franchina
      • Paola Muscolino
      • Alessia Bignucolo
      • Gianluca Vanni
      • Giuliana Ciappina
      • Liliana Montella

    • PubMed: 40290037
    • DOI: 10.3390/nu17061012

    2 Insights on

    • Improved Quality of Life
    • Reduced Fatigue

    • High evidence
    • Rigorous Journal

  • Effect of Combined Vitamin C and Thiamine Therapy on Myocardial and Inflammatory Markers in Cardiac Surgery: A Randomized Controlled Clinical Trial.

    • 2025-03-13
    • RCT · n = 64
    • Nutrients 17(6)
    • • Mantana Saetang
      • Wirat Wasinwong
      • Maliwan Oofuvong
      • Jutarat Tanasansutthiporn
      • Laortip Rattanapittayaporn
      • Sutthasinee Petsakul
      • Pongsanae Duangpakdee
      • Puripong Rodneam
      • Parin Boonthum
      • Supphamongkhon Khunakanan
      • Chaitong Churuangsuk
      • Wilaiwan Sriwimol
      • Amphan Chantarokon
      • Kanjana Nuanjun
      • Dararat Yongsata

    • PubMed: 40290059
    • DOI: 10.3390/nu17061006

    7 Insights on

    • Reduced Total Cholesterol Levels
    • Reduced Interleukin-6 Levels
    • Improved Left Ventricular Ejection Fraction
    • Improved Hemodynamic Stability
    • Reduced Postoperative Arrhythmia
    • Reduced Dobutamine Duration
    • Reduced Duration of Dobutamine Use

    • High evidence
    • Rigorous Journal

  • The effects of concurrent alpha-linolenic acid, L-carnitine supplementation on clinical symptoms, mental health, and quality of life in women with migraine: a randomized, triple-blind, placebo-controlled trial.

    • 2025-03-13
    • RCT · n = 80
    • Nutrition journal 24(1)
    • • Sahar Golpour-Hamedani
      • Mohammad Bagherniya
      • Fariborz Khorvash
      • Awat Feizi
      • Manoj Sharma
      • Gholamreza Askari

    • PubMed: 40082970
    • DOI: 10.1186/s12937-025-01107-7

    7 Insights on

    • Reduced Depression Symptoms
    • Reduced Anxiety
    • Reduced Migraine Severity
    • Reduced Migraine Frequency
    • Reduced Migraine Duration
    • Improved Migraine-Specific Quality of Life
    • Reduced Headache Impact Score

    • High evidence
• March 14

  • Heavy Metal-Gut Microbiota Interactions: Probiotics Modulation and Biosensors Detection.

    • 2025-03-14
    • Review
    • Biosensors 15(3)
    • • Liliana Anchidin-Norocel
      • Oana C Iatcu
      • Andrei Lobiuc
      • Mihai Covasa

    • PubMed: 40136985
    • DOI: 10.3390/bios15030188

    2 Insights on

    • Improved Gut Microbiota Balance
    • Enhanced Detoxification

    • Low evidence

  • Anti-inflammatory and antimicrobial efficacy of coconut oil for periodontal pathogens: a triple-blind randomized clinical trial.

    • 2025-03-14
    • RCT · n = 30
    • Clinical oral investigations 29(4)
    • • Simón Pardiñas López
      • Mónica E García-Caro
      • Juan A Vallejo
      • Pablo Aja-Macaya
      • Kelly Conde-Pérez
      • Paula Nión-Cabeza
      • Ismael Khouly
      • Germán Bou
      • Ana Isabel Rodríguez Cendal
      • Silvia Díaz-Prado
      • Margarita Poza

    • PubMed: 40085302
    • DOI: 10.1007/s00784-025-06267-8

    5 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Interleukin-6 Levels
    • Reduced Pathogenic Bacterial Family Level
    • Reduced Pathogenic Bacterial Species Level
    • Improved Subgingival Microbial Dysbiosis Index

    • High evidence
• March 15

  • A Probiotic Mixture of Lactobacillus rhamnosus LR 32, Bifidobacterium lactis BL 04, and Bifidobacterium longum BB 536 Counteracts the Increase in Permeability Induced by the Mucosal Mediators of Irritable Bowel Syndrome by Acting on Zonula Occludens 1.

    • 2025-03-15
    • n = 28
    • International journal of molecular sciences 26(6)
    • • Maria Raffaella Barbaro
      • Francesca Bianco
      • Cesare Cremon
      • Giovanni Marasco
      • Vincenzo Stanghellini
      • Giovanni Barbara

    • PubMed: 40141298
    • DOI: 10.3390/ijms26062656

    1 Insight on

    • Improved Intestinal Barrier Function

    • Low evidence
• March 17

  • Recovery of Strength After Exercise-Induced Muscle Damage in Vegetarians Consuming the Upper and Lower Ends of Protein Recommendations for Athletes.

    • 2025-03-17
    • RCT
    • Nutrients 17(6)
    • • Nicole Presti
      • Todd C Rideout
      • Jennifer L Temple
      • Brian Bratta
      • David Hostler

    • PubMed: 40292443
    • DOI: 10.3390/nu17061046

    6 Insights on

    • Reduced Muscle Soreness
    • Improved Isometric Strength
    • Improved Vertical Jump
    • Improved Concentric Strength
    • Improved Pressure Pain Threshold
    • Reduced Soreness

    • High evidence
    • Rigorous Journal
• March 18

  • Current Approaches in Cosmeceuticals: Peptides, Biotics and Marine Biopolymers.

    • 2025-03-18
    • Review
    • Polymers 17(6)
    • • Ulya Badilli
      • Ozge Inal

    • PubMed: 40292641
    • DOI: 10.3390/polym17060798

    2 Insights on

    • Improved Skin Barrier Function
    • Reduced Signs of Aging

    • Low evidence

  • BEETter AGING: Short-Term Dietary Nitrate Supplementation Enhances Muscle Contractile Properties in Older But Not in Young Adults.

    • 2025-03-18
    • RCT
    • Medicine and science in sports and exercise 57(8)
    • • Letizia Rasica
      • Marta Colosio
      • Alessandra Ferri
      • Giovanni Baldassarre
      • Chris Easton
      • Mia Burleigh
      • Gianluca Vernillo
      • Roberto Bottinelli
      • Mauro Marzorati
      • Simone Porcelli

    • PubMed: 40098056
    • DOI: 10.1249/mss.0000000000003708

    7 Insights on

    • Increased Time to Exhaustion
    • Improved Maximal Voluntary Isometric Contraction
    • Improved Potentiated Single Twitch Force
    • Improved Double Twitch Force at 100 Hz
    • Reduced Double Twitch Area Under the Curve
    • Reduced Half Relaxation Time
    • Improved Force Production

    • High evidence

  • Efficacy of flaxseed in reducing blood pressure among patients with cardiovascular risk factors: A systematic review and meta-analysis of parallel randomized controlled trials.

    • 2025-03-18
    • Review
    • Journal of cardiovascular and thoracic research 17(1)
    • • Refli Hasan
      • Raed Obaid Saleh
      • Rana H Raheema
      • Hanen Mahmod Hulail
      • Irfan Ahmad
      • Deepak Nathiya
      • Parjinder Kaur

    • PubMed: 40365516
    • DOI: 10.34172/jcvtr.025.33280

    2 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure

    • Low evidence
• March 20

  • The Genomic Characteristics of Potential Probiotics: Two Streptococcus salivarius Isolates from a Healthy Individual in China.

    • 2025-03-20
    • Microorganisms 13(3)
    • • Mingyue Sun
      • Qian Li
      • Feiran Zhang
      • Ding Yao
      • Wenhua Huang
      • Qingyu Lv
      • Hua Jiang
      • Decong Kong
      • Yuhao Ren
      • Shaolong Chen
      • Yongqiang Jiang
      • Peng Liu

    • PubMed: 40142586
    • DOI: 10.3390/microorganisms13030694

    3 Insights on

    • Reduced Pathogen Growth
    • Increased Expression of Antimicrobial Peptide Genes
    • Reduced Oral Pathogen Growth

    • Low evidence
• March 21

  • The impact of prebiotics, probiotics and synbiotics on the prevention and treatment of atopic dermatitis in children: an umbrella meta-analysis.

    • 2025-03-21
    • Systematic Review · n = 150
    • Frontiers in pediatrics 13
    • • Lifeng Wang
      • Lijuan Xu

    • PubMed: 40191649
    • DOI: 10.3389/fped.2025.1498965

    4 Insights on

    • Reduced Incidence of Atopic Dermatitis
    • No Significant Reduction in Atopic Dermatitis Severity
    • Reduced Atopic Dermatitis Severity
    • Reduced SCORAD Score

    • High evidence

  • Bifidobacterium lactis ameliorates AOM/DSS-induced inflammation, dysbiosis, and colonic precancerous lesions.

    • 2025-03-21
    • Applied microbiology and biotechnology 109(1)
    • • Yi-Lin Chan
      • Jun-Cheng Liao
      • Tsung-Lin Li
      • Chang-Jer Wu
      • Yi-Han Chiu

    • PubMed: 40116950
    • DOI: 10.1007/s00253-025-13445-x

    5 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Intestinal Inflammation
    • Improved Gut Microbiome Composition
    • Reduced Inflammation
    • Reduced Abnormal Colonic Lesions

    • Low evidence
    • Animal Study
• March 22

  • Potent Antimicrobial Activity of Aspergillus oryzae Fermentate Against Toxigenic Strains of Clostridioides difficile.

    • 2025-03-22
    • Antibiotics (Basel, Switzerland) 14(4)
    • • Ahmad Alshannaq
      • Morgan Henning
      • Jonah Dixon
      • Colleen Riley
      • Dasol Choi
      • Jae-Hyuk Yu
      • Nasia Safdar

    • PubMed: 40298462
    • DOI: 10.3390/antibiotics14040333

    2 Insights on

    • Reduced Clostridium Difficile Growth
    • Disrupted Bacterial Cell Membranes

    • Low evidence
• March 24

  • Plasma nitrate, dietary nitrate, blood pressure, and vascular health biomarkers: a GRADE-Assessed systematic review and dose-response meta-analysis of randomized controlled trials.

    • 2025-03-24
    • Meta-Analysis · n = 1,823
    • Nutrition journal 24(1)
    • • Mostafa Norouzzadeh
      • Minoo Hasan Rashedi
      • Shadi Ghaemi
      • Niloufar Saber
      • Artemiss Mirdar Harijani
      • Hamzeh Habibi
      • Soroush Mostafavi
      • Fatemeh Sarv
      • Hossein Farhadnejad
      • Farshad Teymoori
      • Mohsen Khaleghian
      • Parvin Mirmiran

    • PubMed: 40128734
    • DOI: 10.1186/s12937-025-01114-8

    5 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure
    • Improved Flow-Mediated Dilation
    • Reduced Pulse Wave Velocity
    • Reduced Augmentation Index

    • High evidence

  • Expert Opinion: Place in Therapy of Probiotics in Infertility and Recurrent Implantation Failure.

    • 2025-03-24
    • Review
    • Cureus 17(3)
    • • Ameet Patki
      • Sujata Kar
      • Nayana Patel
      • Kundan Ingale
      • Kanthi Bansal
      • Poornima Durga

    • PubMed: 40271314
    • DOI: 10.7759/cureus.81067

    2 Insights on

    • Improved Reproductive Health
    • Reduced Recurrent Implantation Failure

    • Low evidence

  • Unlocking the potential of antioxidant supplementation with n-acetylcysteine to improve seminal parameters and analysis of its safety: a systematic review and meta-analysis of randomized controlled trials.

    • 2025-03-24
    • Meta-Analysis
    • Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica 97(1)
    • • Syarif Syarif
      • Moh Anfasa Giffari Makkaraka
      • Ahmad Taufik Fadillah Zainal
      • Ponco Birowo
      • Widi Atmoko

    • PubMed: 40126496
    • DOI: 10.4081/aiua.2025.13750

    4 Insights on

    • Improved Sperm Morphology
    • Improved Sperm Concentration
    • Improved Total Sperm Motility
    • Improved Sperm Volume

    • High evidence
• March 25

  • Assessing the combined effects of Black Cohosh, Soy Isoflavones, and SDG Lignans on menopausal symptoms: a randomized, double-blind, placebo-controlled clinical trial.

    • 2025-03-25
    • RCT · n = 90
    • European journal of nutrition 64(3)
    • • Evgeny Pokushalov
      • A Ponomarenko
      • C Garcia
      • L Kasimova
      • I Pak
      • E Shrainer
      • A Romanova
      • D Kudlay
      • M Johnson
      • R Miller

    • PubMed: 40131516
    • DOI: 10.1007/s00394-025-03588-y

    6 Insights on

    • Increased Estradiol Level
    • Reduced Follicle Stimulating Hormone
    • Reduced Somatic Symptom Score
    • Reduced Psychological Score
    • Reduced Urogenital Symptom Score
    • Reduced Depression Severity

    • High evidence
    • Rigorous Journal

  • Optimizing chronic kidney disease management: The potential of a multi-strain probiotic formulation.

    • 2025-03-25
    • Review
    • World journal of nephrology 14(1)
    • • Deodatta Chafekar

    • PubMed: 40134645
    • DOI: 10.5527/wjn.v14.i1.101515

    6 Insights on

    • Reduced Blood Pressure
    • Improved Gut Microbiota Balance
    • Reduced Blood Glucose Levels
    • Reduced Inflammation
    • Improved Gastrointestinal Symptoms
    • Improved Immune-Related Symptoms

    • Low evidence

  • A Review of the Clinical and Epidemiologic Evidence Relevant to the Impact of Postdiagnosis Isoflavone Intake on Breast Cancer Outcomes.

    • 2025-03-25
    • Review
    • Current nutrition reports 14(1)
    • • Mark Messina
      • Sarah Nechuta

    • PubMed: 40131602
    • DOI: 10.1007/s13668-025-00640-5

    4 Insights on

    • Reduced Breast Cancer Recurrence
    • Reduced Breast Cancer Mortality
    • Reduced Mammographic Density
    • Reduced Breast Cell Proliferation

    • Low evidence

  • Effect of honey-ginger mouthwash on oral mucositis in patients undergoing chemotherapy.

    • 2025-03-25
    • RCT · n = 70
    • Journal of immunoassay & immunochemistry 46(3)
    • • Fatemeh Sadat Razavi
      • Hania Zokaee
      • Mojtaba Sehat
      • Mohsen Taghizadeh
      • Hossein Motedayyen
      • Elaheh Ghasemzadeh Hoseini

    • PubMed: 40134126
    • DOI: 10.1080/15321819.2025.2484645

    2 Insights on

    • Reduced Pain Intensity
    • Reduced Oral Mucositis Severity

    • High evidence
• March 26

  • Comparative efficacy of Mucuna pruriens and conventional levodopa in Parkinson's disease: a randomized controlled trial on pharmacokinetics and clinical perspectives from Asia.

    • 2025-03-26
    • RCT · n = 11
    • Journal of neural transmission (Vienna, Austria : 1996) 132(11)
    • • Thanatat Boonmongkol
      • Onanong Phokaewvarangkul
      • Sornkanok Vimolmangkang
      • Thitima Wattanavijitkul
      • Virunya Komenkul
      • Roongroj Bhidayasiri

    • PubMed: 40137945
    • DOI: 10.1007/s00702-025-02914-2

    1 Insight on

    • Extended ON State Without Dyskinesia

    • High evidence

  • Exploring the therapeutic impact of Salvia officinalis on lipid and oxidative stress markers in patients with polycystic ovary syndrome - a randomized placebo-controlled clinical trial.

    • 2025-03-26
    • RCT
    • BMC complementary medicine and therapies 25(1)
    • • Arezoo Maleki-Hajiagha
      • Faraz Mojab
      • Fardin Amidi
      • Leila Amini

    • PubMed: 40141012
    • DOI: 10.1186/s12906-025-04858-2

    6 Insights on

    • Reduced Total Cholesterol Levels
    • Reduced Low-Density Lipoprotein Level
    • Reduced Triglyceride Levels
    • Increased HDL Cholesterol Levels
    • Improved Antioxidant Capacity
    • Reduced Malondialdehyde Level

    • High evidence

  • Long-read, multi-amplicon sequencing to explore genetic diversity associated with starch degrading phenotypes in amylolytic Lactobacillaceae.

    • 2025-03-26
    • Frontiers in microbiology 16
    • • Sandra A Olivier
      • Michelle K Bull
      • John P Bowman
      • Tom Ross
      • Belinda Chapman

    • PubMed: 40207158
    • DOI: 10.3389/fmicb.2025.1548052

    1 Insight on

    • Improved Starch Degradation Potential

    • Low evidence
• March 27

  • Strain-Specific Therapeutic Potential of Lactiplantibacillus plantarum: A Systematic Scoping Review.

    • 2025-03-27
    • Systematic Review
    • Nutrients 17(7)
    • • Oranut Chatsirisakul
      • Natasha Leenabanchong
      • Yada Siripaopradit
      • Chun-Wei Chang
      • Patsakorn Buhngamongkol
      • Krit Pongpirul

    • PubMed: 40218922
    • DOI: 10.3390/nu17071165

    4 Insights on

    • Improved Immune Function
    • Reduced Inflammation
    • Improved Gastrointestinal Symptoms
    • Enhanced Oral Health

    • High evidence
    • Rigorous Journal

  • Effect of probiotics on necrotizing enterocolitis in preterm infants: a network meta-analysis of randomized controlled trials.

    • 2025-03-27
    • Systematic Review · n = 661
    • BMC pediatrics 25(1)
    • • Yu Dai
      • Qinlei Yu
      • Fan Zhang
      • Ke Ma
      • Xiangyun Yan
      • Wenjuan Chen
      • Xiaohui Chen
      • Shushu Li
      • Shuping Han

    • PubMed: 40140789
    • DOI: 10.1186/s12887-025-05469-z

    6 Insights on

    • No Change in Sepsis Risk
    • Reduced All-Cause Mortality
    • Reduced Length of Hospital Stay
    • Reduced Time to Full Enteral Feeding
    • Reduced Incidence of Necrotizing Enterocolitis
    • Reduced Length of Hospitalization

    • High evidence

  • Effects of natural extracts in cognitive function of healthy adults: a systematic review and network meta-analysis.

    • 2025-03-27
    • Systematic Review
    • Frontiers in pharmacology 16
    • • Zhi-Yuan Wang
      • Ya-Lu Deng
      • Ting-Yuan Zhou
      • Yi Liu
      • Yu Cao

    • PubMed: 40213691
    • DOI: 10.3389/fphar.2025.1573034

    3 Insights on

    • Improved Cognitive Function
    • Improved Memory Function
    • Improved Cognitive Flexibility

    • High evidence

  • Effect of bovine colostrum supplementation on gut health of children: A systematic review.

    • 2025-03-27
    • Systematic Review
    • Journal of pediatric gastroenterology and nutrition 80(6)
    • • Deshna Oswal
      • Mubashir Angolkar
      • N S Mahantashetti
      • Pooja Dhagavkar
      • Shivani Haritay
      • Madan Godbole

    • PubMed: 40150801
    • DOI: 10.1002/jpn3.70033

    2 Insights on

    • Reduced Diarrhea Rate
    • Reduced Duration of Diarrheal Infection

    • High evidence

  • Distinct Effects of Wheat and Black Bean Consumption on Postprandial Vascular Responses in People with Arterial Stiffness: A Pilot Randomized Cross-Over Study.

    • 2025-03-27
    • RCT · n = 9
    • Nutrients 17(7)
    • • Peter Zahradka
      • Danielle Perera
      • Jordan Charney
      • Carla G Taylor

    • PubMed: 40218917
    • DOI: 10.3390/nu17071159

    1 Insight on

    • Increased Systolic Blood Pressure

    • High evidence
    • Rigorous Journal
• March 28

  • Lactobacillus acidophilus LA85 reverses experimental diabetic sensory neuropathy by restoring redox homeostasis in the spinal cord.

    • 2025-03-28
    • Clinical Trial
    • Beneficial microbes 16(5)
    • • Max Denisson Maurı́cio Viana
      • Sthefane Silva Santos
      • Mariana Bastos de Souza
      • Luı́za Carolina França Opretzka
      • Dhara Leite Lopes
      • Milena Botelho Pereira Soares
      • Cristiane Flora Villarreal

    • PubMed: 40312038
    • DOI: 10.1163/18762891-bja00069

    3 Insights on

    • Reduced Neuroinflammation
    • Reduced Diabetic Neuropathic Pain
    • Improved Redox Homeostasis

    • Low evidence
    • Rigorous Journal
    • Animal Study
• Undated – 10 supplement studies

  • Review on the Function, Substrate Affinity, and Potential Application of Bile Salt Hydrolase Originated from Probiotic Strains of Lactobacillus, Bifidobacterium, and Enterococcus.

    • 2025-03
    • Review
    • Food science of animal resources 45(2)
    • • Mo Hyeon Kang
      • Arxel G Elnar
      • Geun-Bae Kim

    • PubMed: 40093624
    • DOI: 10.5851/kosfa.2025.e1

    1 Insight on

    • Reduced Blood Cholesterol

    • Low evidence

  • Bifidobacterium longum subsp. longum XZ01 delays the progression of colon cancer in mice through the interaction between the microbial spatial distribution and tumour immunity.

    • 2025-03
    • International immunopharmacology 150
    • • Ying Chen
      • Jinyun Wu
      • Kaiwei Cai
      • Xiaoyi Xiao
      • Ye Chen
      • Xingyuan Zhang
      • Song Deng
      • Chaoying Pei
      • Yanlong Chen
      • Zhiyong Xie
      • Pei Li
      • Qiongfeng Liao

    • PubMed: 39955918
    • DOI: 10.1016/j.intimp.2025.114283

    1 Insight on

    • Reduced Cancer Progression

    • Low evidence

  • Carnosine supplementation improves cognitive outcomes in younger participants of the NEAT trial.

    • 2025-03
    • RCT · n = 299
    • Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 22(2)
    • • Timothy E O'Toole
      • Alok R Amraotkar
      • Hong Gao
      • Clara G Sears
      • Shesh N Rai
      • Mathias Basner
      • Aruni Bhatnagar

    • PubMed: 39919936
    • DOI: 10.1016/j.neurot.2025.e00541

    4 Insights on

    • Improved Attention Span
    • Improved Delayed Memory
    • Improved Cognitive Speed
    • Improved Speed Score

    • High evidence
    • Large Human Trial

  • NapBiome trial: Targeting gut microbiota to improve sleep rhythm and developmental and behavioural outcomes in early childhood in a birth cohort in Switzerland - a study protocol.

    • 2025-03
    • RCT
    • BMJ open 15(3)
    • • Petra Zimmermann
      • Salome Kurth
      • Stamatios Giannoukos
      • Martin Stocker
      • Nicholas A Bokulich

    • PubMed: 40032396
    • DOI: 10.1136/bmjopen-2024-092938

    2 Insights on

    • Improved Sleep
    • Improved Neurodevelopmental Outcome

    • High evidence

  • Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers.

    • 2025-03
    • RCT · n = 17
    • The Journal of nutrition 155(3)
    • • Alaa T Alhasani
      • Amisha A Modasia
      • Mohamed Anodiyil
      • Maura Corsetti
      • Abdulsalam I Aliyu
      • Colin Crooks
      • Luca Marciani
      • Joshua Reid
      • Gleb E Yakubov
      • Moira Taylor
      • Amanda Avery
      • Hannah Harris
      • Frederick J Warren
      • Robin C Spiller

    • PubMed: 39732438
    • DOI: 10.1016/j.tjnut.2024.12.017

    2 Insights on

    • Reduced Breath Hydrogen Level
    • Reduced Breath Hydrogen

    • High evidence

  • Reduction of postoperative ileus in gastrointestinal surgery: systematic review and meta-analysis.

    • 2025-03
    • Meta-Analysis · n = 4,647
    • Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 29(3)
    • • Doris Sarmiento-Altamirano
      • Daniel Arce-Jara
      • Pablo Balarezo-Guerrero
      • Rafael Valdivieso-Espinoza

    • PubMed: 39788451
    • DOI: 10.1016/j.gassur.2025.101960

    2 Insights on

    • Reduced Time to First Flatus
    • Reduced Time to First Stool

    • High evidence

  • The effect of a 14-day Gymnema sylvestre intervention to reduce sugar intake in people self-identifying with a sweet tooth.

    • 2025-03
    • RCT
    • Appetite 207
    • • Hsiao Wh
      • Kruger R
      • Diako C
      • Nelson I
      • Stice E
      • Ali A

    • PubMed: 39855349
    • DOI: 10.1016/j.appet.2025.107871

    4 Insights on

    • Reduced Sugar-Sweetened Beverage Intake
    • Reduced Sugar Craving
    • Reduced Chocolate Pleasantness Rating
    • Reduced Chocolate Craving

    • High evidence

  • Acute Effect of Honey-sweetened Coffee on Blood Pressure, Heart Rate and Blood Glucose Level in Healthy Female Subjects.

    • 2025-03
    • RCT · n = 10
    • Cardiovascular & hematological disorders drug targets 25(1)
    • • Esther Oluwasola Aluko
      • Etiemem Emmanuel Effiong
      • Titilope Helen Olatunbosun
      • Grace Edet Bassey

    • PubMed: 39757598
    • DOI: 10.2174/011871529x348787241217103918

    5 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure
    • Reduced Fasting Blood Glucose Levels
    • Reduced Mean Arterial Pressure
    • Reduced Heart Rate

    • High evidence

  • An Observational Study on the Association Between Nutritional Intake and Mental Health Among Older Adults in Rural Areas.

    • 2025-03
    • Observational · n = 465
    • Nursing & health sciences 27(1)
    • • Kyeongmin Jang

    • PubMed: 40101703
    • DOI: 10.1111/nhs.70080

    2 Insights on

    • Reduced Depression Symptoms
    • Reduced Anxiety

    • High evidence

  • The effect of saffron supplementation on liver and kidney function, blood glucose and pressure in patients with diabetes and prediabetes: A grade assessed systematic review and meta-analysis of randomized controlled trials.

    • 2025-03
    • Meta-Analysis
    • Prostaglandins & other lipid mediators 177
    • • Jia-Wei Zhang
      • Qing Zhao
      • Zhe Li
      • Qian Liu
      • Sha-Sha Zang
      • Sha Liu

    • PubMed: 39818282
    • DOI: 10.1016/j.prostaglandins.2025.106949

    7 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Systolic Blood Pressure
    • Reduced Blood Urea Nitrogen Levels
    • Reduced Fasting Blood Glucose Levels
    • Reduced Alanine Aminotransferase Level
    • Reduced Creatinine Level
    • Reduced Aspartate Aminotransferase Level

    • High evidence